KR101011356B1 - Stick type cosmetic composition containing rosemarine acid - Google Patents

Abstract

The present invention relates to a stick-type cosmetic composition containing rosemary acid, the rosemary acid is 0.001 to 15% by weight, silicone oil 5 to 50% by weight, wax 5 to 50% by weight, polyalcohol 10 to 70% by weight, emulsifier 0.1 to 20 It comprises a weight percent. Stick-like cosmetic composition according to the present invention is excellent in wrinkle improvement effect as well as high temperature stability, skin safety, transdermal absorption and ease of use.

Rosemary acid, cosmetics, skin, stability, wrinkle improvement, ease of use

Description

A stick type cosmetic compound containing rosmarinic acid}

The present invention relates to a stick-type cosmetic composition containing rosemarine acid, and more particularly, to a stick-type cosmetic composition that not only has an excellent wrinkle improvement effect but also improves high temperature stability, skin safety, transdermal absorption and ease of use.

Skin, the largest organ that makes up the human body, protects the body from physical and chemical stimuli from the outside and maintains homeostasis such as humidity and body temperature. However, ageing or continuous exposure to external stimuli causes skin aging, such as damage to the skin and decreased physiological function. Skin aging is a natural phenomenon that inevitably occurs with age, but the demand for quality of life is increasing due to the improvement of living standards, and the factors that cause skin aging due to various environmental factors have increased. Countermeasures are urgently needed.

Skin wrinkles are determined by collagen collagen fibers present in the dermal layer. Collagen molecules are produced in the fibroblasts and secreted into the dermal layer and then formed into collagen fibers by automatic association ( Implant dentistry , 2002, 11 (3): 280-). 285). Collagen fibers are involved in the skin's mechanical firmness, tissue adhesion, cell adhesion and cell differentiation in the dermal dermal layer ( Journal of the American Academy of Dermatology , 2001, 17 (4): 610-613). If collagen is reduced by endogenous or exogenous factors or continuously deforms, it causes wrinkle formation ( Clinics in geriatric medicine , 2001, 17 (4): 617-630).

In addition, as the aging progresses, the elasticity of the skin decreases. In general, the most important factor in maintaining the elasticity of the skin is elastin, a matrix component present in the dermal layer of the skin. Elastin is a substance present in the extracellular matrix of connective tissue and plays an important role in maintaining elasticity between the collagen matrix and maintaining them firmly.

As the skin ages, the proliferation and regeneration of skin cells decreases. In the epidermis, proliferation of epidermal cells decreases, and metabolism decreases. Like the epidermis, the dermis decreases the proliferative activity of fibroblasts, which are responsible for the synthesis and degradation of glycosaminoglycans and glycoproteins as well as connective tissues such as collagen and elastin, Its metabolic function is also lowered.

Rosmarinic acid, represented by the formula C ₁₈ H ₁₆ O ₆ (molecular weight 360.31), is a powerful natural antioxidant found in nectar, campanula, and many other plants. .

However, since rosemary acid is an extremely poor solubility in oil as a water-soluble component, it is difficult to apply to stick formulations containing a large amount of oil and wax, and there are problems such as sweating due to separation and over time during manufacture.

Korean Laid-Open Patent Publication No. 2006-108665 relates to a composition comprising a rose marinus opininalis plant extract, centella, echinacea or alpinia plant extract, and DNA repair enzyme, wherein at least one component or extract from rosemary ; One or more components or extracts from Centella, Echinacea, Alpinia or mixtures thereof; DNA repair enzymes; And natural ingredients, including one or more pharmaceutically or cosmetically acceptable vehicles, to a cosmetic that prevents signs of aging and promotes recovery from environmental stress.

However, the above technique does not solve the problem of preparing water-soluble rosemary acid into a stick formulation, and uses DNA repair enzymes as essential components in addition to plant extracts.

In addition, Japanese Patent Application Laid-Open No. 2002-308724 relates to safe and environmentally friendly herbal colors and fragrances useful for medicinal cosmetics, and include cosmetics such as lemongrass, jasmine, geranium, rose, rosemary and the like. The present invention relates to a cosmetic containing an essential oil / aroma isolate, but contains rosemarinus essential oil and the like, but is not a specific technique for formulating a stable stick.

Usually stick formulation cosmetics were limited to lipsticks. Recently, however, cosmetics of stick formulations that are easy to carry and use in addition to lipsticks are spreading. Cosmetics prepared by stick formulations include foundation, eye shadow sticks, cosmetic removal or moisturizing sticks in the field of skin care, foaming sticks for skin cleaning and the like. In addition, there are stick cosmetics that are used for the purpose of odor and sweat or smell. The advantage of stick cosmetics is that they are very convenient to carry and use, so the potential product value is very high. However, in the case of a stick cosmetic formulated on a wax base, there is a problem in that it has a bundle property and it is difficult to introduce an active hydrophilic material into the composition.

Therefore, the technical problem to be achieved by the present invention is to provide a stick-type cosmetic composition containing rosemary acid, which has excellent skin wrinkle improvement effect and improved high temperature stability, skin safety, transdermal absorption efficiency, usability and the like.

In order to achieve the above object, the present inventors have prepared and tested a stick composition having a variety of components and contents containing rosemarine acid, and as a result, have come to invent a stick cosmetic composition having a stable and excellent skin improvement effect as follows.

The present invention is a rosemary acid-containing stick, characterized in that it comprises 0.001 to 15% by weight, 5 to 50% by weight of silicone oil, 5 to 50% by weight of wax, 10 to 70% by weight of polyhydric alcohol and 0.1 to 20% by weight of an emulsifier. It provides a type cosmetic composition.

The present invention also provides a rosemary acid-containing stick cosmetic composition, characterized in that the polyhydric alcohol is at least one selected from butylene glycol, propylene glycol, dipropylene glycol, and glycerin.

The present invention also provides a rosemary acid-containing stick-type cosmetic composition, characterized in that the emulsifier is at least one selected from Fiji-7 dimethicone and Cetyl Fiji / Fiji-10 / 1 dimethicone.

The present invention also provides a rosemary acid-containing stick-type cosmetic composition, characterized in that the wax is at least one selected from the group consisting of beeswax, ceresin and candelilla.

In addition, the present invention is prepared by adding silica to the oil phase containing the emulsifier, silicone oil and wax, but is added by 1 to 10% by weight relative to the total weight 100% by weight of the stick-type cosmetic composition, rose-containing acid-containing stick cosmetics To provide a composition.

In addition, the present invention is prepared by adding 1 to 5% by weight of the cyclomethicone / dimethicone copolymer to 100% by weight of the total weight of the stick-type cosmetic composition with an oil-based gelling agent comprising the emulsifier, silicone oil and wax. Provided is a rosemary acid-containing stick cosmetic composition.

The composition according to the present invention is characterized in that it comprises 0.001 to 15% by weight of rosemary acid, 5 to 50% by weight of silicone oil, 5 to 50% by weight of wax, 10 to 70% by weight of polyhydric alcohol, and 0.1 to 20% by weight of an emulsifier. .

The content of rosemarine acid is 0.001 to 15% by weight based on the total weight. If the amount of rose marine acid is less than 0.001% by weight, the effect of improving skin wrinkles is insignificant, and if the amount exceeds 15% by weight, the effect of increasing the content is not economical.

Silicone oil is not particularly limited as long as it is applicable to cosmetics, preferably using dimethicone, the content is 5 to 50% by weight relative to the total weight. The silicone oil of less than 5% by weight is smoothly applied to the skin is lowered, and exceeding 50% by weight is not only economical, but also difficult to prepare a stick formulation.

The content of the polyhydric alcohol is preferably 10 to 70% by weight based on the total weight, and as the polyhydric alcohol, one or more kinds of butylene glycol, propylene glycol, dipropylene glycol, glycerin, etc. may be used. The use of propylene glycol is most preferred for the solubility of rosemarine acid and its usability in skin application. If the polyhydric alcohol is less than 10% by weight relative to the total weight, the components of the cosmetics are not mixed well, and if it exceeds 70% by weight, the preparation of the stick formulation is not easy.

The emulsifiers comprise 0.1 to 20% by weight, preferably 3 to 5% by weight of at least one of Fiji-7 dimethicone and Cetyl Fiji / Fiji-10 / 1dimethicone. The oil phase contains 5 to 50% by weight, preferably 20 to 35% by weight of the emulsifier. If the emulsifier is less than 0.1% by weight, the components of the cosmetics are not mixed well, and if it exceeds 20% by weight is uneconomical.

In addition, beeswax, ceresin, candelilla, and the like may be used as waxes for stick properties. For the stability and spreadability of the skin, ceresin is preferably 5 to 50% by weight, more preferably 10 To 20% by weight. If less than 5% by weight of wax is added, the stick properties will not be properly formed, and if more than 50% by weight, it is uneconomical.

In addition, the composition of the present invention may be added to the oil phase silica in order to improve the hardness and high temperature stability. The silica is to be 1 to 10% by weight, preferably 3 to 6% by weight relative to the total cosmetic composition weight. If it is less than 1% by weight, the effect of improving hardness and high temperature stability is insignificant. If it exceeds 10% by weight, the touch of the cosmetic applied to the skin is lowered, which is uneconomical.

It has also been found that high temperature stability is further improved when cyclomethicone / dimethicone copolymers are used as the oily gelling agent. In the present invention, it was found that the high temperature stability is most effective when the cyclomethicone / dimethicone copolymer is included in an amount of 0.1 to 10% by weight, preferably 1 to 5% by weight. If it is less than 0.1 weight%, the effect of improving high temperature stability is insignificant, and if it is more than 10 weight%, it is uneconomical.

The present invention relates to a stick-type cosmetics containing rosemary acid, not only excellent skin wrinkle improvement effect, but also excellent in high temperature stability, convenient to carry, easy to use when partially applied to the skin, almost no skin irritation and skin penetration Easy to maximize the efficacy as a cosmetic.

Hereinafter, the configuration of the present invention will be described in more detail with reference to the following examples. However, it is obvious to those skilled in the art that the scope of the present invention is not limited to the scope of the following examples.

Examples 1-4

To prepare a stick cosmetic composition containing rosemarine acid, phase A and phase B as shown in Table 1 below were dissolved by heating to 60-70 ° C., respectively, and phase A was slowly 1,500-2,000 rpm for 10 minutes. Mix with input. After the addition was completed, the mixture was stirred and mixed at 3,000 rpm for 10 minutes, and then poured into a mold of a stick shape.

Prize ingredient Example 1
(weight%) Example 2
(weight%) Example 3
(weight%) Example 4
(weight%) A Fiji-7 Dimethicone 4.0 4.0 4.0 4.0 Dimethicone 25.0 30.0 25.0 25.0 Ceresin 15.0 10.0 15.0 15.0 Silica - - 0.5 - Cyclomethicone / Dimethicone Copolymer - - - 3.0 B Propylene glycol To 100 To 100 To 100 To 100 Rosemarine acid 0.5 0.5 0.5 0.5 NaCl 0.3 0.3 0.3 0.3 antiseptic Quantity Quantity Quantity Quantity

Comparative Examples 1 to 4

A stick is manufactured by the same method as the preparation method of Examples 1 to 4 with the composition as shown in Table 2.

Prize ingredient Comparative Example 1
(weight%) Comparative Example 2
(weight%) Comparative Example 3
(weight%) Comparative Example 4
(weight%) A Fiji-7 Dimethicone 4.0 4.0 - 4.0 Dimethicone 25.0 25.0 25.0 25.0 Ceresin 15.0 - 15.0 15.0 B Propylene glycol To 100 To 100 To 100 To 100 Rosemarine acid - 0.5 0.5 0.5 NaCl 0.3 0.3 0.3 - antiseptic Quantity Quantity Quantity Quantity

Test Example 1 Skin Wrinkle Improvement Effect

In order to verify the wrinkle-improving effect of the stick containing rosemary acid in women aged 30-40 years, 20 subjects were selected. The cosmetic of Example 1 containing rosemary acid was applied twice a day at a frequency of 6 weeks around the right eye of a woman, and the cosmetic of Comparative Example 1 containing no rosemary acid was applied around the other eye. After 6 weeks, the wrinkle improvement effect was visually observed and the results were summarized as follows.

A noticeable effect Mitigating effect no effect Example 1 11 9 0 Comparative Example 1 0 4 16

As can be seen from the results of Table 3, another embodiment 1 of the present invention exhibits an excellent effect on wrinkle improvement, but it can be seen that the cosmetic composition of Comparative Example 1, which does not contain rosmarinic acid, significantly reduces the wrinkle improvement effect.

Test Example 2: Skin Elasticity Enhancing Effect

60 healthy females (average age 35 years old) aged 30-40 at a temperature of 22-24 ° C and a relative humidity of 55% were divided into six groups, and the cosmetics of Example 1 and Comparative Example 1 were each focused for 12 weeks. After application (2 times / day), skin elasticity was measured using a skin elasticity measuring instrument (Cutometer SEM 575, C + K Electronic Co., Germany). The test results are described as ΔR5 value [R5 (12 weeks) -R5 (0 weeks)], which is an average value of each test group of the cutometer SEM 575. The R5 value represents the elastic modulus of elasticity, which is closer to 1 Indicates excellent.

In addition, the degree of improvement was calculated by the following formula 1 and the calculation results are shown in Table 4.

Before application After application Skin elasticity enhancing effect (△ R5) % Improvement Example 1 0.72 1.20 0.48 66.7 Comparative Example 1 0.70 0.79 0.09 12.9

As shown in Table 4, the cosmetic of Example 1 according to the present invention can be seen that the skin elasticity improving effect is remarkable.

Test Example 3: High Temperature Stability

In order to confirm the high temperature stability of the stick cosmetics prepared in Examples 1 to 4 and Comparative Examples 2, 3, 4 and stored in a constant temperature bath at 42 ℃ 1 week, 2 weeks, 4 weeks, 8 weeks later, 16 Each week was observed and the results are shown in Table 5.

Formulation 1 week later after 2 weeks 4 weeks later 8 weeks later 16 weeks later Example 1 +++ +++ ++ ++ ++ Example 2 +++ +++ ++ ++ + Example 3 +++ +++ +++ +++ ++ Example 4 +++ +++ +++ ++ ++ Comparative Example 2 ++ ++ + + - Comparative Example 3 ++ ++ ++ + + Comparative Example 4 +++ ++ ++ + +

+++ has little separation and little discoloration.

++ has some separation and some discoloration.

+ Has significant separation and discoloration.

-The separation is very severe and discoloration is very severe.

As can be seen in Table 5, Examples 1 to 4 were excellent in overall high temperature stability, while Comparative Examples 1 to 4 can be seen that the stability is significantly low. And it can be seen that Example 3 containing the silica in the oil phase and Example 4 containing the gelling agent is more excellent in high temperature stability.

Test Example 4: Convenience

Ease of use was evaluated for Examples 1 to 4 and Comparative Examples 2, 3 and 4. Sensory evaluation was performed on 60 women aged 30-40 years (mean age 35 years) and the results are shown in Table 6 below.

Item Example 1 Example 2 Example 3 Example 4 Comparative Example 2 Comparative Example 3 Comparative Example 4 Portability 5.8 5.8 5.8 5.8 2.6 5.8 5.8 Skin adhesion 5.6 5.2 6.0 5.6 4.2 3.8 4.0 Moist 5.5 5.0 5.8 5.8 3.2 4.2 4.4 pepper 5.8 5.4 6.0 6.0 2.2 5.4 5.4

* Criteria: 1 (very bad), 2 (bad), 3 (slightly bad), 4 (medium), 5 (slightly good), 6 (good), 7 (very good)

As can be seen in Table 6, the embodiments were evaluated as being convenient to carry, good skin adhesion, moist and no irritation, and excellent use convenience.

Test Example 5: Skin Safety

Skin stability was evaluated by skin patch experiment with Example 1 and Comparative Example 2, the patch was applied to 60 women aged 30-40 years (average age 35 years) after applying the patch to the forearm 48 hours 1 hour to 2 hours after the removal of the primary judgment was made after 72 hours or 96 hours and the results are shown in Table 7 below.

Item Positive reaction % Example 1 1 (+) 1.7 Comparative Example 2 4 (+) 6.7

As shown in Table 7, the stick-type cosmetic composition of Example 1 according to the present invention has excellent skin stability, but it can be seen that the composition of Comparative Example 2, which is a creamy emulsion, has severe skin side effects.

Test Example 6 Skin Penetration Effect

The skin permeation experiment of the cosmetic composition obtained from the said Example 1 and the comparative example 2 was performed using the Franz diffusion cell (effective area: 2cm <2>). 0.9% saline was used as the aqueous phase. First, the aqueous phase was filled in a Franz Diffusion cell and maintained at 37 ° C., followed by mounting a hairless mouse skin epidermis, and applying the samples obtained in Example 1 and Comparative Example 2 to the epidermal layer of the skin to investigate the skin penetration rate of the sample. The results are shown in Table 8 below. Each sample was applied 500 mu g, and the patch was cut into ² cm ² and used. The skin was mounted on a diffusion device and a sample was applied to the upper skin layer. During the experiment, the aqueous phase was agitated at 300 rpm using a magnetic stirrer, and 200 µl of the aqueous phase was quantified by HPLC after a certain time after application for quantification of the permeated drug, and the Franz Diffusion cell was previously prepared. It was refilled with the aqueous phase warmed to ° C. Waters HPLC system was used to measure drug release behavior and content in patches. The column used was XTerra column (reverse phase column) of Waters, and the mobile phase solvent was measured by methanol: purified water (80%: 20%), flow rate 1.0ml / min, photodiode array detector.

division Cumulative Skin Penetration after 24 Hours (㎍ / ㎠) Example 1 120 Comparative Example 2 60

As shown in Table 8, it can be seen that the cosmetic of Example 1 having a stick shape is more effective to penetrate the skin than the cosmetic of Comparative Example 2 having a cream form.

Claims (6)

Rosemary acid-containing stick-type cosmetic composition comprising 0.001 to 15% by weight of rosemarine acid, 5 to 50% by weight of silicone oil, 5 to 50% by weight of wax, 10 to 70% by weight of polyhydric alcohol and 0.1 to 20% by weight of emulsifier. . The method of claim 1, Rosemary acid-containing stick type cosmetic composition, characterized in that the polyhydric alcohol is at least one selected from butylene glycol, propylene glycol, dipropylene glycol and glycerin. The method of claim 1, The emulsifier is Rosemary acid-containing stick-type cosmetic composition, characterized in that at least one selected from sebum-7 dimethicone and cetyl sebum / sebum-10 / 1 dimethicone. The method of claim 1, Wherein the wax is beeswax, ceresin and candelilla Rosemary acid-containing stick cosmetic composition characterized in that at least one member selected from the group consisting of. The method of claim 1, The addition of silica to the oil phase containing the emulsifier, silicone oil and wax, but is prepared by adding 1 to 10% by weight relative to the total weight 100% by weight of the stick-type cosmetic composition. The method of claim 1, Rosemary acid-containing stick, characterized in that prepared by adding 1 to 5% by weight of cyclomethicone / dimethicone copolymer to 100% by weight of the total weight of the stick-type cosmetic composition as an oil-based gelling agent comprising the emulsifier, silicone oil and wax Type cosmetic composition.