CN112675065A - Body lotion and preparation method thereof - Google Patents

Abstract

The invention provides a body lotion and a preparation method thereof, wherein the body lotion comprises the following components, by weight, 0.2-1.0% of gluconolactone, 0.1-1.5% of lactobionic acid, 0.5-3% of glycolic acid, 0.1-1.0% of hydroxyethyl piperazine ethanesulfonic acid, 0.5-1.5% of hydrogenated lecithin and 0.1-0.5% of bisabolol. The body lotion of the invention can not only promote skin metabolism and achieve the effects of softening cutin and smoothing skin, but also ensure that the lotion has good stability and safety.

Description

Body lotion and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, and particularly relates to body lotion and a preparation method thereof.

Background

CN110101588A discloses a whitening and speckle removing composition, a skin care lotion containing the same and a preparation method thereof, but because the skin care lotion contains fruit acids and/or precursors including glycolic acid, lactic acid and gluconolactone, the irritation is very obvious, and the skin care effect on the skin is poor.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide a body emulsion and a preparation method thereof.

In order to achieve the purpose, the invention adopts the technical scheme that: a body lotion comprising, in percent, gluconolactone 0.2% to 1.0%, lactobionic acid 0.1% to 1.5%, glycolic acid 0.5% to 3%, hydroxyethylpiperazine ethanesulfonic acid 0.1% to 1.0%, hydrogenated lecithin 0.5% to 1.5%, and bisabolol 0.1% to 0.5%.

The inventor discovers through research that when gluconolactone, lactobionic acid, glycolic acid, hydroxyethyl piperazine ethane sulfonic acid, hydrogenated lecithin and bisabolol are compounded and used in body lotion, the skin lotion can well promote the renewal and soften cutin, can effectively improve the rough skin and increase the skin elasticity, reduces the irritation caused by fruit acid components and improves the stability of the body lotion.

Preferably, the weight ratio of gluconolactone, lactobionic acid, hydrogenated lecithin, bisabolol in the body emulsion is gluconolactone: lactobionic acid: hydrogenated lecithin: bisabolol (3-10): (5-15): (5-15): (1-5).

The inventors have found through studies that the body lotion can improve the skin-roughening and skin-elasticity improving properties when the weight ratio of gluconolactone, lactobionic acid, hydrogenated lecithin, bisabolol meets the above conditions.

Preferably, the weight ratio of gluconolactone, lactobionic acid, hydrogenated lecithin, bisabolol in the body emulsion is gluconolactone: lactobionic acid: hydrogenated lecithin: bisabolol (6-10): (8-15): (8-12): (1-5).

The inventors have found through studies that the body lotion can improve the skin-roughening and skin-elasticity improving properties when the weight ratio of gluconolactone, lactobionic acid, hydrogenated lecithin, bisabolol meets the above conditions.

Preferably, the body lotion comprises the components of, in percentage by weight, gluconolactone 0.6% to 1.0%, lactobionic acid 0.8% to 1.5%, glycolic acid 1.6% to 3%, hydroxyethylpiperazine ethanesulfonic acid 0.6% to 1.0%, hydrogenated lecithin 0.5% to 1.5%, and bisabolol 0.1% to 0.5%.

The inventor finds that the body lotion has better performance of improving rough skin and increasing skin elasticity and has low cost through research.

Preferably, the body lotion further comprises sodium hydroxide, and the pH of the body lotion is controlled to be 3.5-4.5 by the sodium hydroxide.

Preferably, the particle size of the emulsion for the body is 10 to 100 nm.

Preferably, the body emulsion further comprises the following components, by weight, 2% -6% of glycerol, 3% -8% of 1, 3-butanediol, 0.2% -0.5% of xanthan gum, 100.2% -0.4% of polyquaternium, 201.5% -3% of tween-1.5%, 0.1% -0.5% of cetostearyl alcohol, 2% -5% of diisopropyl adipate, 1% -4% of octyldodecanol and 0.3% -1.5% of tocopherol acetate.

The invention also provides a preparation method of the body emulsion, which comprises the following steps

(1) Uniformly mixing water, glycerol, 1, 3-butanediol, xanthan gum and polyquaternium-10 at a temperature of 80-85 ℃ according to a weight ratio to obtain a phase A;

(2) sequentially adding gluconolactone, lactobionic acid, glycolic acid and hydroxyethyl piperazine ethanesulfonic acid into the phase A and uniformly mixing to obtain a phase B;

(3) uniformly mixing tween-20, hydrogenated lecithin, cetostearyl alcohol, diisopropyl adipate, octyldodecanol, bisabolol and tocopheryl acetate at the temperature of 60-65 ℃ to obtain a phase C;

(4) mixing the phase B and the phase C, adjusting the pH value to 3.5-4.5 by using sodium hydroxide, and dispersing and stirring for 2-5 minutes in an IKA T25 dispersion machine at 6000-10000 rpm to obtain a mixed solution;

(5) and (3) homogenizing and dispersing the mixed solution obtained in the step (4) for 10-20 minutes at 65-75 ℃, under the pressure of 150-180 Mpa and under the flow rate of 6-10L/h to obtain the body emulsion with the particle size of 10-100 nm.

The preparation method of the emulsion for the body obtains the emulsion with the particle size of 10-100 nm through a homogenization process, so that the emulsion for the body has good stability.

The invention has the beneficial effects that: the body lotion provided by the invention can promote skin metabolism, has the effects of softening cutin and smoothing skin, and has good stability and safety.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

The invention provides a body lotion, which comprises the following components in percentage by weight:

phase A: water To 100%

2 to 6 percent of glycerin

3 to 8 percent of 1, 3-butanediol

0.2 to 0.5 percent of xanthan gum

Polyquaternium-100.2% -0.4%

Controlling the pH value of the solution to 3.5-4.5 by sodium hydroxide

B: gluconolactone 0.5-2.0%

0.5 to 2.5 percent of lactobionic acid

0.5 to 5 percent of glycolic acid

0.1 to 1.5 percent of hydroxyethyl piperazine ethane sulfonic acid

And C phase: tween-201.5% -3%

0.5 to 1.5 percent of hydrogenated lecithin

0.1 to 0.5 percent of hexadecanol and octadecanol

2 to 5 percent of diisopropyl adipate

1 to 4 percent of octyl dodecanol

0.1 to 0.5 percent of bisabolol

0.3 to 1.5 percent of tocopherol acetate

Specifically, the body lotion formulations of examples 1 to 3 and comparative examples 1 to 4 are shown in table 1.

TABLE 1 body lotion formulation

Examples 1 to 3, comparative examples 1 to 2, and comparative examples 4 to 7 were prepared by a method comprising the following steps in addition to the difference in components:

(1) uniformly mixing water, glycerol, 1, 3-butanediol, xanthan gum and polyquaternium-10 at a temperature of 80-85 ℃ according to a weight ratio to obtain a phase A;

(2) sequentially adding gluconolactone, lactobionic acid, glycolic acid and hydroxyethyl piperazine ethanesulfonic acid into the phase A and uniformly mixing to obtain a phase B;

(3) uniformly mixing tween-20, hydrogenated lecithin, cetostearyl alcohol, diisopropyl adipate, octyldodecanol, bisabolol and tocopheryl acetate at the temperature of 60-65 ℃ to obtain a phase C;

(4) mixing the phase B and the phase C, adjusting the pH value to 3.5-4.0 by using sodium hydroxide, and dispersing and stirring for 2-5 minutes in an IKA T25 dispersion machine at 6000-10000 rpm to obtain a mixed solution;

(5) and (3) homogenizing and dispersing the mixed solution obtained in the step (4) for 10-20 minutes at 65-75 ℃, under the pressure of 150-180 Mpa and under the flow of 8L/h to obtain the body emulsion with the particle size of 10-100 nm.

The preparation method of comparative example 3 includes the following steps:

(1) uniformly mixing water, glycerol, 1, 3-butanediol, xanthan gum and polyquaternium-10 at a temperature of 80-85 ℃ according to a weight ratio to obtain a phase A;

(2) sequentially adding gluconolactone, lactobionic acid, glycolic acid and hydroxyethyl piperazine ethanesulfonic acid into the phase A and uniformly mixing to obtain a phase B;

(3) uniformly mixing tween-20, hydrogenated lecithin, cetostearyl alcohol, diisopropyl adipate, octyldodecanol, bisabolol and tocopheryl acetate at the temperature of 60-65 ℃ to obtain a phase C;

(4) mixing the phase B and the phase C, adjusting the pH value to 3.5-4.0 by using sodium hydroxide, and dispersing and stirring for 2-5 minutes in an IKA T25 dispersion machine at 6000-10000 rpm to obtain a mixed solution; this was the body lotion of comparative example 3.

Effect test

1. And (3) stability investigation:

placing the emulsion in a sealed transparent glass bottle, placing the sample in 80g per bottle at 45 ℃, 25 ℃ and 2000rpm for centrifugal stability test, initially obtaining uniform milky emulsion, and recording the time of layering, demulsification, precipitation and aggregation. The results are shown in Table 2.

TABLE 2 stability of body lotions

As can be seen from Table 2, the stability of examples 1 to 3 and comparative examples 1 to 2, comparative examples 5 and 7 was the best, and the stability of comparative example 3, which was prepared by a general emulsification process, was poor. Comparative example 4 contains a high concentration of a single fruit acid, which is more ionic and less stable than the examples. Comparative example 6 lacks the emulsification aid of hydrogenated soft phospholipids and the stability is slightly worse than the examples. The results show that the emulsion prepared by the composite acid component and the process has better stability.

2. Mild testing

The test basis is as follows: test of skin Patch on human body according to cosmetic safety technical Specification 2015 edition

The test method comprises the following steps: a 24h closed patch test was used.

32 healthy volunteers were invited, age 20-59 years, without history of allergy.

The selection area is not more than 50mm²And 0.020 to 0.025g of the products of examples 1 to 3 and comparative examples 1 to 7 are respectively weighed into a spot tester with a proper spot tester depth of about 1 mm. After cleaning the back of the subject, a patch tester containing the above product was applied to the curved side of the forearm of the subject for 24 hours. Subject maintained plaque for 24hThe part to be pasted is dry, and violent movement, scratching of spot test part, long-time sunlight irradiation and the like are avoided. And after 24h, removing the tester and marking, and after 30min, judging under sufficient light after the pressure marks disappear. The classification standard of the adverse skin reaction is shown in the following table, and the adverse skin reaction result of each product is shown in the following table 3.

Grading standard of adverse skin reactions

TABLE 3 mildness of body lotions

Examples 1-3 and comparative examples 1-2 of the invention, comparative examples 5 and 6 have no serious adverse reaction to skin, 32 subjects have no positive reaction, and comparative example 3 is prepared by a common emulsification process and has no slow release effect, so the irritation is stronger than that of the examples. Comparative example 4 has a very irritating effect with a single high concentration of fruit acid (a concentration commonly used in the market). Comparative example 7 lacks bisabolol and is more irritating than the examples. Therefore, the emulsion prepared by the invention can improve the safety of a formula system of the fruit acid emulsion and has no adverse reaction to human bodies.

3. The body lotion of the present invention has an effect of enhancing the elasticity of the skin

The test method comprises the following steps: the skin elasticity before and after use was measured by a skin elasticity tester MPA580 of CK, germany, and the degree of change in skin elasticity was evaluated from the difference between values before and after the skin elasticity value R2, where Δ R2 ═ R2 (after use) -R2 (before use), and the greater the Δ R2 value, the more the elasticity was enhanced.

Healthy volunteers were invited to 70 persons, one group of 10 persons each, for a test period of 15 days, once a day, in the morning and evening, and the products of examples 1 to 3 and comparative examples 1 to 7 were used on the inner side of the crank arm, respectively, to test the R2 values before use and 15 days after use, respectively. The calculated Δ R2 values are shown in table 4.

TABLE 4 enhancement of skin elasticity by body lotions

As can be seen from Table 4, the emulsions of examples 1-3 according to the present invention significantly enhanced skin elasticity, while the comparative examples 1-2 were much less effective than the examples due to the lack of formulation of two of the fruit acids. Comparative example 3 is slightly less effective than example, but has poor stability and high irritation. While comparative example 4 was slightly less effective than example, but was too irritating. Comparative example 5 and comparative example 6 lack a fruit acid, lack hydrogenated soft phospholipid, respectively, and are less effective than the examples. Comparative example 7 has similar effects to those of examples, but is highly irritating.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (8)

1. A body lotion comprising, in percent, gluconolactone 0.2% to 1.0%, lactobionic acid 0.1% to 1.5%, glycolic acid 0.5% to 3%, hydroxyethylpiperazine ethanesulfonic acid 0.1% to 1.0%, hydrogenated lecithin 0.5% to 1.5%, and bisabolol 0.1% to 0.5%.

2. The body lotion according to claim 1, wherein the weight ratio of gluconolactone, lactobionic acid, hydrogenated lecithin, bisabolol in the body lotion is gluconolactone: lactobionic acid: hydrogenated lecithin: bisabolol (3-10): (5-15): (5-15): (1-5).

3. The body lotion according to claim 2, wherein the weight ratio of gluconolactone, lactobionic acid, hydrogenated lecithin, bisabolol in the body lotion is gluconolactone: lactobionic acid: hydrogenated lecithin: bisabolol (6-10): (8-15): (8-12): (1-5).

4. The body lotion according to claim 1, characterized in that it comprises, in percentages, gluconolactone 0.6% to 1.0%, lactobionic acid 0.8% to 1.5%, glycolic acid 1.6% to 3%, hydroxyethylpiperazine ethanesulfonic acid 0.6% to 1.0%, hydrogenated lecithin 0.5% to 1.5% and bisabolol 0.1% to 0.5%.

5. The body lotion according to claim 1 or 2, wherein the body lotion further comprises sodium hydroxide, and the sodium hydroxide controls the pH of the body lotion to 3.5 to 4.0.

6. The body lotion according to claim 1 or 2, wherein the particle size of the body lotion is 10 to 100 nm.

7. The body lotion according to claim 1 or 2, wherein the body lotion further comprises the following components, by weight, 2% to 6% of glycerin, 3% to 8% of 1, 3-butanediol, 0.2% to 0.5% of xanthan gum, 100.2% to 0.4% of polyquaternium, 201.5% to 3% of tween, 0.1% to 0.5% of cetostearyl alcohol, 2% to 5% of diisopropyl adipate, 1% to 4% of octyldodecanol, and 0.3% to 1.5% of tocopheryl acetate.

8. A method of preparing a body lotion according to claim 7, comprising the steps of

(1) Uniformly mixing water, glycerol, 1, 3-butanediol, xanthan gum and polyquaternium-10 at a temperature of 80-85 ℃ according to a weight ratio to obtain a phase A;

(2) sequentially adding gluconolactone, lactobionic acid, glycolic acid and hydroxyethyl piperazine ethanesulfonic acid into the phase A and uniformly mixing to obtain a phase B;

(3) uniformly mixing tween-20, hydrogenated lecithin, cetostearyl alcohol, diisopropyl adipate, octyldodecanol, bisabolol and tocopheryl acetate at the temperature of 60-65 ℃ to obtain a phase C;

(4) mixing the phase B and the phase C, and dispersing and stirring the mixture for 2-5 minutes at 6000-10000 rpm by an IKA T25 dispersion machine to obtain a mixed solution;

(5) and (3) homogenizing and dispersing the mixed solution obtained in the step (4) for 10-20 minutes at 65-75 ℃, under the pressure of 150-180 Mpa and under the flow rate of 6-10L/h to obtain the body emulsion with the particle size of 10-100 nm.