CN113208947A - Anti-aging moisturizing composition and application thereof - Google Patents
Anti-aging moisturizing composition and application thereof Download PDFInfo
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- CN113208947A CN113208947A CN202110648670.4A CN202110648670A CN113208947A CN 113208947 A CN113208947 A CN 113208947A CN 202110648670 A CN202110648670 A CN 202110648670A CN 113208947 A CN113208947 A CN 113208947A
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- aging
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- moisturizing composition
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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Abstract
The invention provides an anti-aging moisturizing composition and application thereof. The anti-aging moisturizing composition comprises: aminobutyric acid, tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomers and bisabolol. The anti-aging moisturizing composition disclosed by the invention not only can effectively improve the anti-aging effect of a product, but also can promote sleep and improve skin luster, and meanwhile, can inhibit the release of inflammatory factors, promote the repair of skin and play a role in long-acting moisturizing, so that the purpose of delaying aging is achieved.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-aging moisturizing composition and application thereof.
Background
Skin aging refers to the aging damage of skin function, which reduces the protection ability and regulation ability of skin to human body, so that the skin can not adapt to the change of internal and external environment, and the appearance of the whole condition such as color, shape and texture changes. Skin aging is a process by which the human body functions or develops rapidly or slowly naturally under the influence of internal and external factors, mainly due to endogenous aging (time accumulation) and exogenous aging (external exposure to the environment).
More and more scholars consider that aging of the skin is a continuous chronic inflammatory process characterized by increased pro-inflammatory cytokines, cellular aging transitions, and the like. Inflammatory aging refers to a persistent, low-grade inflammation associated with aging, which accumulates over time and gradually leads to tissue damage. It is considered one of the driving forces for many age-related diseases, such as diabetes, atherosclerosis, age-related macular degeneration (AMD), and skin aging.
At present, common anti-aging skin care products on the market are generally declared to be anti-aging by oxidation resistance, but the anti-aging mechanism is relatively complex, and although the anti-aging developed according to a certain mechanism can play a certain effect, the overall effect is not good.
CN112402280A discloses an efficacy-promoting composition comprising a polymeric hyaluronic acid or a salt thereof, a hydrolyzed hyaluronic acid or a salt thereof, an acetylated hyaluronic acid or a salt thereof, a tetrahydropyrimidine or a derivative thereof, ergothioneine, yeast/rice fermentation product filtrate, aminobutyric acid. The efficacy promoting composition disclosed by the invention has a certain capability of moisturizing and repairing skin, but has poor antioxidant and anti-aging effects on skin.
CN108261376A discloses a three-dimensional moisturizing factor. The three-dimensional moisturizing factor comprises, by weight, 30 parts of saccharide isomer, 5-12 parts of ectoin, 1-5 parts of malt extract, 0.1-1.5 parts of caprylyl hydroximic acid, 0.1-0.4 part of 1, 2-hexanediol, 0.1-0.5 part of sodium polyglutamate, 0.01-0.5 part of hyaluronic acid, 0.01-0.1 part of sodium hyaluronate and 68-80 parts of water; the three-dimensional moisturizing factor also has poor effects of resisting oxidation and aging of skin.
CN101496772A discloses an anti-aging and anti-allergy composition, which contains: the anti-aging and anti-allergy active ingredient is prepared by the compatibility of plant extract natural alpha-bisabolol and proanthocyanidin, and a carrier acceptable for cosmetics, skin care products or medicines. The composition has an anti-aging and anti-allergic effect that is to be improved and a moisturizing effect that is poor when applied to the skin.
Therefore, it is important to develop an anti-aging product with multiple anti-aging effects.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an anti-aging moisturizing composition and application thereof. The composition has multiple anti-aging and moisturizing effects, can effectively improve the anti-aging effect of the product, can promote sleep and improve skin luster, can inhibit the release of inflammatory factors, promotes the repair of skin, and plays a role in long-acting moisturizing, thereby achieving the purpose of delaying aging.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides an anti-aging moisturizing composition comprising: aminobutyric acid, tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomers and bisabolol.
In the invention, the aminobutyric acid, the tetrahydro-methyl pyrimidine carboxylic acid, the saccharide isomer and the bisabolol are matched with each other, so that the composition has a synergistic effect, can be activated, promotes the skin to synthesize collagen, stimulates the synthesis of ceramide, has an effective moisturizing effect, can increase the skin elasticity, enables the skin to be more young, and achieves the effects of moisturizing and wrinkle resistance.
The aminobutyric acid (GABA), also called gamma-aminobutyric acid, 4-aminobutyric acid and aminobutyric acid, is a non-protein amino acid widely distributed in animals and plants, and can promote epidermal cell proliferation and keratinocyte involucrin production, relieve the tension of muscle cells, reduce fine lines, relieve wrinkles, reduce the damage of ultraviolet rays to the skin, improve the cell activity and play an irreplaceable role in the regulation of the living activities of organisms.
Among them, ECTOIN (ECTOIN), which is the most widely distributed compatible solute in the bacterial community, is found to be compatible with intracellular metabolism, does not affect the biomacromolecule function or physiological function of cells, and is an important osmotic pressure compensation solute. The intensive charge distribution on the surface of the ectoine enables the ectoine to further strengthen the hydrogen bond effect between water molecules through the electrostatic interaction between the ectoine and the water molecules, reduces the water activity, complexes the water molecules and has the long-acting moisturizing effect.
Wherein the saccharide isomerate is derived from plant D-glucose, and is polysaccharides composed of psicose, glucose, mannose, fructose, glucose, and galactose; similar to the composition of a carbohydrate complex (NMF-natural moisturizing factor) in the skin, the composition has the effects of instantly and deeply moisturizing, improving the water retention capacity of the skin, simultaneously improving the expression level of acid sphingomyelinase genes, stimulating the synthesis of ceramide, deeply moisturizing after being used, and reducing the irritation of harmful substances to the skin.
Wherein, the bisabolol can not only effectively inhibit inflammation and relieve skin injury caused by ultraviolet rays, but also has bacteriostatic activity.
Preferably, the anti-aging moisturizing composition comprises the following components in parts by weight: 0.01-3 parts of aminobutyric acid, 0.01-4 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.01-5 parts of saccharide isomer and 0.01-4 parts of bisabolol.
In the anti-aging moisturizing composition of the present invention, the content of aminobutyric acid is 0.01 to 3 parts, and may be, for example, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts.
In the anti-aging moisturizing composition of the present invention, the content of the tetrahydro-methylpyrimidine carboxylic acid is 0.01 to 4 parts, and may be, for example, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 part, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, etc.
In the antiaging moisturizing composition of the invention, the content of saccharide isomer is 0.01 to 5 parts, and may be, for example, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, or the like.
In the anti-aging moisturizing composition of the present invention, the content of bisabolol is 0.01 to 4 parts, and may be, for example, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, or the like.
Preferably, the anti-aging moisturizing composition comprises the following components in parts by weight: 0.1-2 parts of aminobutyric acid, 0.3-2 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-3 parts of saccharide isomer and 0.1-2 parts of bisabolol.
In a second aspect, the present invention provides the use of an anti-aging moisturizing composition as described in the first aspect in the preparation of a cosmetic.
Preferably, the cosmetic may be formulated into a lotion, cream, lotion, essence, pack, foundation, lotion, cream, beauty lotion, etc.
Preferably, the cosmetic may also include art-acceptable excipients well known to those skilled in the art, including but not limited to: humectant, emollient, chelating agent, thickener, emulsifier, antiseptic, etc., and can be selected according to formula.
In a third aspect, the present invention provides a serum comprising the anti-aging moisturizing composition according to the first aspect.
Preferably, the essence comprises: an anti-aging moisturizing composition as described in the first aspect, a humectant, and water.
Preferably, the moisturizer comprises a combination of at least two of sodium hyaluronate, 1, 3-propanediol, 1, 2-hexanediol, caprylhydroxamic acid, glycerol, beta-glucan, glyceryl polyether-26, trehalose, squalane, or ceramide.
Preferably, the humectant is a combination of sodium hyaluronate, 1, 3-propanediol, 1, 2-hexanediol, caprylyl hydroxamic acid, and trehalose.
In the invention, the specific moisturizing agents are matched with each other, so that the moisturizing effect is further improved obviously, the skin is moisturized, the skin feel is not greasy, the skin is soft, and the aging is delayed.
Preferably, the humectant comprises the following components in parts by weight: 0.1-10 parts of sodium hyaluronate, 0.5-2 parts of 1, 3-propylene glycol, 0.5-2 parts of 1, 2-hexanediol, 0.05-0.1 part of caprylyl hydroximic acid and 0.5-2 parts of trehalose.
The amount of sodium hyaluronate added in the humectant may be 0.1 to 10 parts, for example, 0.1 part, 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or the like.
The amount of 1, 3-propanediol to be added in the humectant is 0.5 to 2 parts, and may be, for example, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts or the like.
The amount of 1, 2-hexanediol added to the humectant may be, for example, 0.5 to 2 parts, and may be, for example, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, or the like.
The amount of caprylhydroxamic acid added to the moisturizer is 0.05 to 0.1 part, and may be, for example, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part, 0.1 part, or the like.
The amount of trehalose added to the humectant may be, for example, 0.5 to 2 parts, and may be, for example, 0.5 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, or the like.
Preferably, the essence comprises the following components in percentage by mass: the anti-aging moisturizing composition of the first aspect comprises 0.01-15% of humectant and the balance of water.
The anti-aging moisturizing composition is 0.01 to 15%, for example, 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10%, 11%, 12%, 13%, 14%, 15%, etc., based on 100% of the total mass of the essence.
The content of the moisturizer is 0.5 to 25% based on 100% of the total mass of the essence, and may be, for example, 0.5%, 0.6%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 16%, 18%, 20%, 22%, 25%, or the like.
Preferably, the essence comprises the following components in percentage by mass: 0.01-3% of aminobutyric acid, 0.01-4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.01-5% of saccharide isomer, 0.01-3% of bisabolol, 0.5-25% of humectant and the balance of water.
Preferably, the essence comprises the following components in percentage by mass: 0.01-3% of aminobutyric acid, 0.01-4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.01-5% of saccharide isomer, 0.01-3% of bisabolol, 0.1-1% of sodium hyaluronate, 0.5-2% of 1, 3-propanediol, 0.5-2% of 1, 2-hexanediol, 0.05-0.1% of caprylyl hydroximic acid, 0.5-1% of trehalose and the balance of water.
In a fourth aspect, the present invention provides a method for preparing the essence of the third aspect, wherein the method for preparing the essence comprises: mixing the anti-aging moisturizing composition, the humectant and water, and stirring to obtain the essence.
Preferably, the moisturizer is a combination of sodium hyaluronate, 1, 3-propylene glycol, 1, 2-hexanediol, caprylyl hydroximic acid and trehalose, and the preparation method of the essence comprises the following steps:
(1) mixing water, sodium hyaluronate, 1, 3-propylene glycol and trehalose, heating, preserving heat and homogenizing to obtain a mixed solution;
(2) and (2) mixing the mixed solution obtained in the step (1), the anti-aging and moisturizing composition, 1, 2-hexanediol and caprylyl hydroximic acid, and stirring to obtain the essence.
Preferably, in the step (1), the heating, the heat preservation and the homogenization are carried out in an emulsifying pot.
Preferably, in step (1), the temperature of the heating and heat preservation is 80-90 ℃, for example, 80 ℃, 82 ℃, 84 ℃, 86 ℃, 88 ℃, 90 ℃ and the like, and the time of the heating and heat preservation is 20-30min, for example, 20min, 22min, 24min, 26min, 28min, 30min and the like.
Preferably, in step (1), the rotation speed of the homogenization is 300-400r/min, such as 300r/min, 320r/min, 340r/min, 360r/min, 380r/min, 400r/min, etc., and the time of the homogenization is 3-10min, such as 3min, 5min, 7min, 9min, 10min, etc.
Preferably, in the step (2), the temperature of the mixing is 45 ℃ or less, for example, 45 ℃, 44 ℃, 43 ℃, 42 ℃, 41 ℃, 40 ℃, 35 ℃ or the like can be used.
Compared with the prior art, the invention has the following beneficial effects:
(1) the multiple anti-aging composition comprises the specially selected aminobutyric acid, the tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomerate and the bisabolol as main raw material components, can be activated, promotes the skin to synthesize collagen per se, stimulates the synthesis of ceramide, and has effective moisturizing and moisturizing effects, can increase the skin elasticity, enables the skin to be more young and achieves the moisturizing and anti-wrinkle effects through the synergistic cooperation of the active components;
(2) the multiple anti-aging composition disclosed by the invention is applied to cosmetics, and can bring good effects of moisturizing, skin firming and skin elasticity enhancing, so that the skin is more youthful.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Example 1
The embodiment provides an anti-aging moisturizing composition, which comprises the following components in parts by weight: 0.1 part of aminobutyric acid, 0.3 part of tetrahydro-methyl pyrimidine carboxylic acid, 0.1 part of saccharide isomer and 0.1 part of bisabolol.
Example 2
The embodiment provides an anti-aging moisturizing composition, which comprises the following components in parts by weight: 0.5 part of aminobutyric acid, 0.5 part of tetrahydro-methyl pyrimidine carboxylic acid, 0.5 part of saccharide isomer and 0.5 part of bisabolol.
Example 3
The embodiment provides an anti-aging moisturizing composition, which comprises the following components in parts by weight: 1 part of aminobutyric acid, 0.5 part of tetrahydro-methyl pyrimidine carboxylic acid, 0.5 part of saccharide isomer and 1 part of bisabolol.
Example 4
The embodiment provides an anti-aging moisturizing composition, which comprises the following components in parts by weight: 0.5 part of aminobutyric acid, 1 part of tetrahydro-methyl pyrimidine carboxylic acid, 0.5 part of saccharide isomer and 1 part of bisabolol.
Example 5
The embodiment provides an anti-aging moisturizing composition, which comprises the following components in parts by weight: 0.5 part of aminobutyric acid, 1 part of tetrahydro-methyl pyrimidine carboxylic acid, 1 part of saccharide isomer and 0.5 part of bisabolol.
Example 6
The embodiment provides an anti-aging moisturizing composition, which comprises the following components in parts by weight: 2 parts of aminobutyric acid, 2 parts of tetrahydro-methyl pyrimidine carboxylic acid, 3 parts of saccharide isomer and 2 parts of bisabolol.
Comparative example 1
This comparative example provides an anti-aging moisturizing composition that differs from example 4 only in that it does not contain bisabolol; the anti-aging moisturizing composition comprises the following components in parts by weight: 1 part of aminobutyric acid, 1 part of tetrahydro-methyl pyrimidine carboxylic acid and 1 part of saccharide isomer.
Comparative example 2
This comparative example provides an anti-aging moisturizing composition that differs from example 4 only in that it does not contain aminobutyric acid; the anti-aging moisturizing composition comprises the following components in parts by weight: 1 part of tetrahydro-methyl pyrimidine carboxylic acid, 1 part of saccharide isomer and 1 part of bisabolol.
Comparative example 3
This comparative example provides an anti-aging moisturizing composition that differs from example 4 only in that no tetrahydro-methyl pyrimidine carboxylic acid is present; the anti-aging moisturizing composition comprises the following components in parts by weight: 1 part of aminobutyric acid, 1 part of saccharide isomer and 1 part of bisabolol.
Comparative example 4
This comparative example provides an anti-aging moisturizing composition, differing from example 4 only in that it does not contain saccharide isomers; the anti-aging moisturizing composition comprises the following components in parts by weight: 1 part of aminobutyric acid, 1 part of tetrahydro-methyl pyrimidine carboxylic acid and 1 part of bisabolol.
Comparative example 5
This comparative example provides an anti-aging moisturizing composition, differing from example 4 only in that aminobutyric acid and bisabolol are not contained; the anti-aging moisturizing composition comprises the following components in parts by weight: 1.5 parts of tetrahydro-methyl pyrimidine carboxylic acid and 1.5 parts of saccharide isomer.
Comparative example 6
This comparative example provides an anti-aging moisturizing composition that differs from example 4 only in that it does not contain aminobutyric acid and tetrahydro-methyl pyrimidine carboxylic acid; the anti-aging moisturizing composition comprises the following components in parts by weight: 1.5 parts of saccharide isomer and 1.5 parts of bisabolol.
Comparative example 7
This comparative example provides an anti-aging moisturizing composition that differs from example 4 only in that it does not contain aminobutyric acid, saccharide isomers, bisabolol; the anti-aging moisturizing composition comprises the following components in parts by weight: 3 parts of tetrahydro-methyl pyrimidine carboxylic acid.
Application example 1
The application example provides essence which comprises the following components in percentage by mass:
the preparation method of the essence comprises the following steps:
(1) adding water, 1, 3-propylene glycol, sodium hyaluronate and trehalose into an emulsifying pot, heating to 85 ℃, keeping the temperature for 25min, and homogenizing at the rotating speed of 350r/min for 8 min;
(2) when the temperature is reduced to 45 ℃, the multiple anti-aging moisturizing composition, the 1, 2-hexanediol and the caprylyl hydroximic acid are added, the mixture is uniformly stirred, and the material can be discharged after the quality inspection is qualified.
Application example 2
The application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Application example 3
The application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Application example 4
The application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Application example 5
The application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Application example 6
The application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 1
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 2
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 3
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 4
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 5
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 6
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Comparative application example 7
The comparative application example provides essence which comprises the following components in percentage by mass:
the preparation method of the five anti-aging moisturizing essences is the same as that of application example 1.
Test example 1
Product safety testing
The test method comprises the following steps:
1. 30 participants were selected.
2. The application examples 1-6 and comparative application examples 1-7 were loaded into a plaque tester chamber as test samples, and one group was selected as a blank control, and the plaque tester was taped to the forearm of the subject for 24 hours.
3. Respectively observing skin reaction 48h after removing the tested substance spot tester, and the grading standard of skin reaction of skin closed type spot test is shown in Table 1
TABLE 1
| Extent of reaction | Grade of rating | Skin reactions |
| - | 0 | Negative reaction |
| ± | 1 | Suspicious reaction, only slight erythema |
| + | 2 | Erythema, infiltrates, edema, and possibly pimples |
| ++ | 3 | Erythema, infiltration, edema, papule reactions beyond the test area |
| +++ | 4 | Obvious erythema, severe infiltration, edema, and fusional package diagnosis |
The specific test results are shown in table 2 below:
TABLE 2
The results show that through the patch test, the skin reaction is observed after 48 hours after the test object patch tester is removed, no adverse reaction occurs in the class test in application examples 1-6, and the effect is better than that of the essence provided in comparative application examples 1-7. The essence containing the composition of the aminobutyric acid, the tetrahydro-methyl pyrimidine carboxylic acid, the saccharide isomer and the bisabolol is low in irritation and high in safety, and can exert a synergistic effect to the greatest extent, so that the respective effects of the essence are further improved, and the anti-allergy effect is improved.
Test example 2
Product stability testing
(1) Test subjects: applying the essence prepared in examples 1-6;
(2) the test principle is as follows: and testing the pH value of the essence before the experiment, determining the corresponding parameter range when the product is qualified, and observing the appearance and the properties of the product. Testing each group of sample parameters after the stability test, and observing whether the appearance of the sample is changed or not, thereby judging whether the product stability is good or not;
(3) the test method comprises the following steps:
and (3) centrifugal stability test: taking 3 groups of 50g samples, placing the samples in a centrifuge, keeping the centrifuge at a rotating speed of 3000r/min, centrifuging for 10min, taking out, testing whether the pH value and the viscosity value of the samples are changed or not, and comparing whether the appearance, namely the color and the smell of the samples are changed or not;
high temperature stability test: taking 3 groups of 50g samples, placing the samples in an oven at 40 ℃ for 1 month, taking out the samples, placing the samples at room temperature for 24 hours, recovering the samples to normal temperature, and testing whether the physical and chemical properties and the appearance of the samples are changed or not;
low temperature stability experiment: taking 3 groups of 50g samples, placing the samples in a refrigerator at the temperature of-20 ℃, freezing for 1 month, taking out, placing the samples at room temperature for 24 hours, recovering to the normal temperature, and detecting whether the physical and chemical properties and the appearance of the samples are changed;
the specific test results are shown in table 3 below:
TABLE 3
| Sample (I) | pH | Centrifugal test | High temperature test | Low temperature test |
| Application example 1 | 6.5 | No layering, uniform color and no change | No layering, uniform color and no change | Color morphology is unchanged |
| Application example 2 | 6.4 | No layering, uniform color and no change | No layering, uniform color and no change | Color morphology is unchanged |
| Application example 3 | 6.5 | No layering, uniform color and no change | No layering, uniform color and no change | Color morphology is unchanged |
| Application example 4 | 6.6 | No layering, uniform color and no change | No layering, uniform color and no change | Color morphology is unchanged |
| Application example 5 | 6.5 | No layering, uniform color and no change | No layering, uniform color and no change | Color morphology is unchanged |
| Application example 6 | 6.4 | No layering, uniform color and no change | No layering, uniform color and no change | Color morphology is unchanged |
The results show that after the tests on the high-low temperature stability and the centrifugal stability of the essence provided by the application examples 1-6, the stability of the multiple anti-aging moisturizing essence is good, so that the product has good stability.
Test example 3
Protease activity inhibition assay
(1) Inhibitory Activity on Elastase
Elastin is the main component of skin connective tissue, an insoluble fibrin, which accounts for only 2-4% of the dermal matrix, but plays an important role in skin elasticity. It also includes a network of collagen fibers beneath the epidermis, usually degraded by elastase, which hydrolyzes peripheral and structural proteins in the connective tissue. Elastase can be activated by ultraviolet light or ROS, so that inhibition of elastase activity can prevent elastase-induced skin aging and a decrease in skin elasticity, in a manner known per se.
The essences of application examples 1 to 6 and comparative application examples 1 to 7 were measured for their elastase inhibitory activity. Elastase acts on MAAPVN to generate p-nitroaniline, which absorbs at 410nm and is yellow, and the activity of elastase is examined by monitoring the release of p-nitroaniline at 410 nm. (ii) spectrophotometrically determining elastase inhibition of individual samples using MAAPVN as a substrate;
100 μ L Tris-HCl (pH 8.0), 50 μ L elastase and 50 μ L sample (negative replaced by buffer), shaking, pre-incubating at 25 ℃ for 20min, adding 50 μ L5 mmol/L MAAPVM (blank replaced by buffer), shaking, pre-incubating at 25 ℃ for 60min, and measuring absorbance at 410nm with microplate reader;
(2) inhibitory Activity on collagenase
Inhibitory activity against collagenase. The substance produced by the action of the collagenase on the FALGPA has the absorption at 335nm, and the activity of the collagenase is examined by monitoring the absorption value at 335 nm. Spectrophotometrically measuring the collagenase inhibitory effect of the individual samples using FALGPA as a substrate;
the specific operation is as follows: mu.L of the sample was incubated with 20. mu.L of ChC solution (collagenase type I solution 1.1U/mL) and 60. mu.L of glycine buffer (0.05M) at 37 ℃ for 20 min. The reaction was initiated by adding 50. mu.L of 1mM FALGPA solution. For the sample blank, glycine buffer was added instead of FALGPA solution. After incubation at 37 ℃ for 30min, the absorbance was measured at 335 nm.
The results of the experiment are shown in table 4:
TABLE 4
| Sample solution | Elastase inhibition (%) | Collagenase inhibition (%) |
| Application example 1 | 46.4 | 80.1 |
| Application example 2 | 58.8 | 94.5 |
| Application example 3 | 60.1 | 93.8 |
| Application example 4 | 59.3 | 94.0 |
| Application example 5 | 59.6 | 94.2 |
| Application example 6 | 61.8 | 96.1 |
| Comparative application example 1 | 35.4 | 68.5 |
| Comparative application example 2 | 36.6 | 66.3 |
| Comparative application example 3 | 34.8 | 65.7 |
| Comparative application example 4 | 35.0 | 65.2 |
| Comparative application example 5 | 30.1 | 40.6 |
| Comparative application example 6 | 30.9 | 39.7 |
| Comparative application example 7 | 20.6 | 19.8 |
The test results in table 4 show that the inhibition rate of the evolution solution added with the composition of the invention on elastase inhibition can reach more than 46%, and the inhibition rate on collagenase can reach more than 80%; therefore, the multiple anti-aging composition provided by the invention comprises specifically selected aminobutyric acid, tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomer and bisabolol as main raw material components, can be activated, promotes the skin to synthesize collagen by itself, stimulates the synthesis of ceramide, and can effectively improve the elastase inhibition rate and the collagenase inhibition rate through the synergistic cooperation of the active ingredients. As can be seen from the comparison of application example 4 and comparative application examples 1-7, the compositions lack any component or components, and the inhibition rates of elastase and collagenase are significantly reduced.
Test example 4
Oxidation resistance test (free radical scavenging experiment)
The essences of application examples 1-6 and comparative application examples 1-7 were tested for total antioxidant capacity using ABTS +. scavenging capacity assay. ABTS is oxidized into green ABTS +. under the action of a proper oxidant, the generation of ABTS + is inhibited in the presence of antioxidant, and the total antioxidant capacity of the sample can be measured and calculated by measuring the absorbance of ABTS at 734 nm:
the specific operation method comprises the following steps: diluting the ABTS stock solution with 10mmol/L PBS (pH 7.4) 50 times to give an ABTS working solution with an absorbance of 0.7 + -0.02 (30 deg.C) at 734 nm; preparing a Vc solution (positive) and a sample solution to be detected; and (3) sample determination: sucking 200 μ L ABTS working solution, adding 20 μ L sample solution (diluted 10 times), oscillating for 10s, standing at 30 deg.C for 6min, and measuring light absorption value at 734 nm; the calculation formula is as follows:
the results of the experiment are shown in table 5:
TABLE 5
The test results in table 5 show that the clearance rate of the evolution solution added with the composition of the invention to ABTS + can reach more than 80%; therefore, the multiple anti-aging composition provided by the invention comprises specifically selected aminobutyric acid, tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomer and bisabolol as main raw material components, can be activated, promotes the skin to synthesize collagen by itself, stimulates the synthesis of ceramide, and can further improve ABTS +. clearance rate through synergistic cooperation of the active ingredients. However, as can be seen from the comparison between application example 4 and comparative application examples 1 to 7, the composition lacks any component or components and has poor scavenging effect on free radicals, i.e., low antioxidant and anti-aging ability.
Test example 5
Test of moisturizing Effect
Test subjects: the essences prepared in application examples 1 to 6 and comparative application examples 1 to 7;
the 8 areas of the test, each 1X 1cm in size, were marked on the face of the subject using a template prepared beforehand2The other half face is used as blank control area, all test areas are marked with skin marker pen, and the test areas are used once in the morning and at night, and the sample is continuously used for 30 days, and the sample usage amount is 2mg/cm2. Any other skin care products or medicines cannot be used within 30 days;
this test instrument was a corneometer (ck) and was used to determine the moisture content of the skin. The test time points are 1w, 2w, 3w, 4w (w represents weeks) before and after sample application. Before each test, the skin was washed with water, and after 30min, the skin was dried before the test.
The test results are shown in table 6:
TABLE 6
As can be seen from the test results in table 6, the multiple anti-aging composition according to the present invention comprises specifically selected aminobutyric acid, tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomers, and bisabolol as main raw material components, such that the composition of the present invention not only has effective moisturizing and moisturizing effects, but also can increase skin elasticity, make skin more young, and achieve moisturizing and anti-wrinkle effects. As is clear from comparison between application example 4 and comparative application examples 1 to 7, the composition lacks any component or components, and the moisturizing ability thereof is remarkably reduced.
The applicant states that the present invention is illustrated by the above examples to show the anti-aging moisturizing composition and the application thereof, but the present invention is not limited to the above examples, i.e., it does not mean that the present invention must be implemented by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. An anti-aging moisturizing composition, wherein the anti-aging moisturizing composition comprises: aminobutyric acid, tetrahydro-methyl pyrimidine carboxylic acid, saccharide isomers and bisabolol.
2. The anti-aging moisturizing composition as claimed in claim 1, wherein the anti-aging moisturizing composition comprises, in parts by weight: 0.01-3 parts of aminobutyric acid, 0.01-4 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.01-5 parts of saccharide isomer and 0.01-4 parts of bisabolol.
3. The anti-aging moisturizing composition according to claim 1 or 2, wherein the anti-aging moisturizing composition comprises, in parts by weight: 0.1-2 parts of aminobutyric acid, 0.3-2 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.1-3 parts of saccharide isomer and 0.1-2 parts of bisabolol.
4. Use of the anti-aging moisturizing composition according to any one of claims 1 to 3 for the preparation of cosmetics.
5. An essence comprising the anti-aging moisturizing composition according to any one of claims 1 to 3.
6. The essence of claim 5, wherein the essence comprises: the anti-aging moisturizing composition of any one of claims 1-3, a humectant, and water.
7. The essence of claim 5 or 6, wherein the moisturizer comprises a combination of at least two of sodium hyaluronate, 1, 3-propanediol, 1, 2-hexanediol, caprylhydroxamic acid, glycerol, beta-glucan, glyceryl polyether-26, trehalose, squalane, or ceramide;
preferably, the humectant is a combination of sodium hyaluronate, 1, 3-propanediol, 1, 2-hexanediol, caprylyl hydroximic acid and trehalose;
preferably, the humectant comprises the following components in parts by weight: 0.1-10 parts of sodium hyaluronate, 0.5-2 parts of 1, 3-propylene glycol, 0.5-2 parts of 1, 2-hexanediol, 0.05-0.1 part of caprylyl hydroximic acid and 0.5-2 parts of trehalose.
8. The essence according to any one of claims 5 to 7, wherein the essence comprises, by mass: the anti-aging moisturizing composition of any one of claims 1-3, 0.01-15%, 0.5-25%, and the balance water;
preferably, the essence comprises the following components in percentage by mass: 0.01-3% of aminobutyric acid, 0.01-4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.01-5% of saccharide isomer, 0.01-3% of bisabolol, 0.5-25% of humectant and the balance of water;
preferably, the essence comprises the following components in percentage by mass: 0.01-3% of aminobutyric acid, 0.01-4% of tetrahydro-methyl pyrimidine carboxylic acid, 0.01-5% of saccharide isomer, 0.01-3% of bisabolol, 0.1-1% of sodium hyaluronate, 0.5-2% of 1, 3-propanediol, 0.5-2% of 1, 2-hexanediol, 0.05-0.1% of caprylyl hydroximic acid, 0.5-1% of trehalose and the balance of water.
9. The essence according to any one of claims 5 to 8, which is prepared by: mixing the anti-aging moisturizing composition as defined in any one of claims 1 to 3, a humectant and water, and stirring to obtain the essence.
10. The essence of claim 9, wherein the moisturizer is a combination of sodium hyaluronate, 1, 3-propanediol, 1, 2-hexanediol, caprylyl hydroxamic acid, and trehalose;
the preparation method of the essence comprises the following steps:
(1) mixing water, sodium hyaluronate, 1, 3-propylene glycol and trehalose, heating, preserving heat and homogenizing to obtain a mixed solution;
(2) mixing the mixed solution obtained in the step (1), the anti-aging and moisturizing composition as defined in any one of claims 1 to 3, 1, 2-hexanediol and caprylyl hydroximic acid, and stirring to obtain the essence;
preferably, in the step (1), the heating and heat preservation temperature is 80-90 ℃, and the heating and heat preservation time is 20-30 min;
preferably, in the step (1), the rotation speed of the homogenization is 300-;
preferably, in step (2), the temperature of the mixing is 45 ℃ or less.
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| CN114376932A (en) * | 2022-02-25 | 2022-04-22 | 山东花物堂生物科技有限公司 | Composition for improving stimulation of gamma-aminobutyric acid and preparation method and application thereof |
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Non-Patent Citations (1)
| Title |
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| 四川肽美生物科技有限责任公司: "MODE BELLE水磁场果冻霜", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/FW.JSP；HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=2021020312012687GY6&NID=2021020312012687GY6》 * |
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|---|---|---|---|---|
| CN114376932A (en) * | 2022-02-25 | 2022-04-22 | 山东花物堂生物科技有限公司 | Composition for improving stimulation of gamma-aminobutyric acid and preparation method and application thereof |
| CN114376932B (en) * | 2022-02-25 | 2024-04-16 | 山东花物堂生物科技有限公司 | Composition for improving gamma-aminobutyric acid irritation as well as preparation method and application thereof |
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