CN108619033B - Whitening skin-care essence with synergistic whitening effect and preparation method thereof - Google Patents
Whitening skin-care essence with synergistic whitening effect and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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Abstract
The invention discloses whitening skin-care essence with a synergistic whitening effect and a preparation method thereof. The whitening skin care essence comprises nicotinamide, a whitening compound 1, a whitening compound 2, a citrus peel extract, arbutin and the like. The formula of the whitening skin-care essence disclosed by the invention selects raw materials with synergistic effect, so that the tyrosinase activity can be inhibited, the melanin transfer can be inhibited, the skin color can be lightened, and simultaneously, the joint synergistic effect of each node in a whitening path can be realized, and finally, the safe, effective and stable whitening effect is achieved.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to whitening and skin-care essence with a synergistic whitening effect and a preparation method thereof.
Background
East asian women were beautiful with white from ancient times, and many methods were used for whitening. Such as milk baths, etc. Even many toxic substances, such as the early lead and mercury facings, were used until the last century.
With the development of modern science and technology, people know skin color systems more and more deeply. The shade of skin color is regulated by various factors, but still depends mainly on the content and distribution of melanin. Melanin is produced by melanocytes. Melanocytes, one of the important constituent cells of the skin, are dendritic processes through which melanin formed within the cell is transported into the cells of the stratum corneum. It forms an epidermal unit with keratinocyte at a ratio of 1: 36, and exists in epidermal basal layer, and melanocyte determines skin color by synthesizing melanin, and can absorb ultraviolet ray to prevent organism from being damaged by ultraviolet ray. The specific melanin formation process is as follows: when ultraviolet rays irradiate the skin, keratinocytes are stimulated to produce inflammatory factors, histamine, and the like, and at the same time, DNA is damaged and free radicals are generated. Melanocytes are stimulated by inflammatory factors, free radicals, etc. to differentiate and accelerate. The activity of internal tyrosinase is increased, tyrosine is converted into dopa under the catalytic action of tyrosinase, and is further converted into dopaquinone, and the dopaquinone is converted into melanin through free radical reaction. Melanosomes are delivered to keratinocytes via dendrites. Eventually resulting in pigmentation of the pigment in the skin.
Many whitening agents have been developed and selected since the recent years. At present, one of the most effective skin lightening actives is hydroquinone, but hydroquinone has a small molecular weight, destroys melanocytes, and may induce inflammation. Therefore, hydroquinone is subject to strict regulations in most countries of the world and is prohibited from being used as a cosmetic ingredient. Rhododendrol was a whitening active primarily by certain famous cosmetic companies in japan, but the problem of excessive whitening was noted later.
Azelaic acid is a naturally occurring medium chain fatty acid. It is an important skin whitening agent and has tyrosinase inhibiting effect. There are some technical and formulation problems in application. First, azelaic acid must be effective at high concentrations. At high concentrations azelaic acid does not dissolve, making the formulated cosmetic of poor quality, especially very thick systems difficult to spread. Secondly, azelaic acid has a higher melting point and is generally more difficult to formulate.
L-ascorbic acid and its derivatives and licorice extract are easy to discolor, and its stability is not a little problem, and special attention is required for use.
At present, in order to make a short-term profit, some illegal merchants add glucocorticoid to cosmetics such as facial masks. The whitening and firming effect can be generated in a short time, but the long-term use of the whitening and firming agent has very serious consequences on the skin of a human.
There are also many companies that develop some whitening compositions, and more products with simply superimposed effects, which are difficult to achieve. How to develop a whitening scheme with high efficiency, safety, stability and synergy becomes a difficult point in the current cosmetic industry.
Disclosure of Invention
In order to overcome the technical defects, the invention provides the whitening skin-care essence with a synergistic whitening effect. The whitening skin-care essence can absorb ultraviolet rays, inhibit inflammatory factors, repair damaged DNA, remove free radicals, inhibit tyrosinase, reduce melanin, and phagocytize melanin, thereby achieving the purpose of whitening. The skin care essence not only can play an important role in tyrosinase inhibition and melanin transfer, but also can play a synergistic role in other aspects, so that the skin whitening effect can be achieved, and the skin care essence can be balanced and cooperated without causing negative feedback phenomenon.
In order to solve the problems, the invention adopts the following technical scheme:
the whitening skin-care essence with the synergistic whitening effect comprises the following raw material components in parts by weight:
wherein the whitening complex 1 comprises water, butylene glycol, arbutin, citric acid, sodium sulfite, acetyl tyrosine, strawberry saxifrage extract, peony root extract, aminopropanol ascorbic acid phosphate, scutellaria root extract, glutathione, hydrolyzed cherry plum; the whitening compound 2 comprises water, glycerol, sucrose dilaurate, polysorbate-20, pea extract, phenoxyethanol, caprylyl glycol, p-anisic acid, and sorbic acid. In the whitening complex 1: arbutin and radix Scutellariae extract can absorb ultraviolet; radix Scutellariae extract and radix moutan extract have effects in inhibiting inflammatory factor activity; arbutin can inhibit tyrosinase activity; the extract of strawberry saxifrage, the extract of radix Scutellariae and the aminopropanol ascorbic acid phosphate ester can inhibit the natural oxidative polymerization of melanin and reduce the formation of melanin; the extract of herba Saxifragae can repair DNA damage caused by ultraviolet; glutathione can promote the synthesis of pheomelanin but not eumelanin; acetyl tyrosine competes with tyrosine for tyrosinase; the aminopropanol ascorbic acid phosphate and citric acid promote cell proliferation and keratinocyte renewal; hydrolyzed cherry plum inhibits melanin from being engulfed by keratinocytes.
Through research and experimental analysis on the mechanism, in the whitening and skin-care essence, when the dosage of the whitening compound 1 is lower than 1%, the whitening effect of the whitening and skin-care essence is not obvious. When the whitening complex 1 is used in an amount of more than 4%, the heat-resistant and light-resistant stability of the whitening and skin-care essence is deteriorated, and thus the amount is selected to be 1-4 parts.
The sucrose dilaurate and the pea (PISUM SATIVUM) extract in the whitening compound 2 can effectively inhibit the maturation of melanosomes, act on B16 melanocytes, and can remarkably reduce the formation of melanin and reduce the activity of tyrosinase. In the whitening and skin-care essence, when the dosage of the whitening compound 2 is less than 1%, the whitening effect is not obvious. When the whitening complex 2 is used in an amount of more than 3%, the heat-resistant and light-resistant stability of the whitening skin-care essence is deteriorated. The amount is therefore chosen to be 1 to 3 parts.
The citrus peel extract has the function of coordinating with other components to make the skin smoother and brighter in the whitening and skin-care essence. The total flavone amount and kind are one standard of the quality. The citrus peel extract adopted in the whitening and skin-care essence adopts a carbon dioxide supercritical extraction technology, the content of the total flavone of the citrus peel extract extracted by the technology can be more than 2.5 percent, is obviously higher than that extracted by other methods, and has the advantages of environmental friendliness and energy conservation. In the test of the whitening skin-care essence, when the content of the citrus peel extract is less than 0.2%, the effect is slight, and when the content of the citrus peel extract is more than 1.5%, the whitening skin-care essence is easy to change color under illumination and 45 ℃ heat resistance, so 0.5-1.5 parts is selected.
The whitening skin care essence uses arbutin as a cosmetic grade raw material with the content of over 98 percent, has the capability of inhibiting the activity of key enzyme-tyrosinase in the process of melanin generation, and also has the effect of absorbing ultraviolet rays. Because arbutin has similarity with tyrosine in structure, the arbutin can compete with tyrosine to bind tyrosinase in the process of synthesizing melanin by tyrosine, thereby reducing the effect of tyrosinase on synthesizing melanin. When the content of the whitening skin care essence arbutin is lower than 0.1%, the whitening effect is very small; when the content is more than 0.8%, the whitening and skin-care essence is easy to turn red in the storage process, so 0.1-0.5 part is selected.
Further, the whitening skin care essence with the synergistic whitening effect comprises the following components in parts by weight:
the nicotinamide adopted by the whitening skin-care essence is a high-purity raw material, and the nicotinic acid content of the nicotinamide is lower than 100 PPM. It has outstanding effects in inhibiting melanosome transfer and accelerating the repair of damaged DNA. When the content of the nicotinamide in the whitening skin care essence is lower than 1%, the overall whitening effect is greatly weakened through tests. When the nicotinamide content is more than 3%, the cytotoxicity is too high through in vitro cell tests. Therefore, 1 to 3 parts of the catalyst is selected.
Specifically, the whitening compound 1 comprises the following raw material components in parts by weight: 40-50 parts of water, 40-50 parts of butanediol, 0.3-0.8 part of arbutin, 0.3-0.6 part of citric acid, 0.4-0.6 part of sodium sulfite, 0.1-0.3 part of acetyl tyrosine, 0.01-0.30 part of strawberry saxifrage extract, 0.01-0.20 part of peony root extract, 0.001-0.100 part of aminopropanol ascorbic acid phosphate, 0.01-0.10 part of scutellaria root extract, 0.001-0.100 part of glutathione and 0.01-0.60 part of hydrolyzed cherry plum.
Specifically, the whitening compound 2 comprises the following raw material components in parts by weight: 36.95-50.0 parts of water, 28-30 parts of glycerol, 20-22 parts of sucrose dilaurate, 5-6 parts of polysorbate-20, 2-3 parts of pea extract, 2-3 parts of phenoxyethanol, 1-2 parts of caprylyl glycol, 0.3-0.5 part of p-anisic acid and 0.2-0.3 part of sorbic acid.
Preferably, the nicotinic acid content of the nicotinamide of the invention is less than 100 PPM; the citrus peel extract is extracted by carbon dioxide supercritical extraction, and the content of total flavonoids is more than or equal to 2.5 percent; the arbutin is a cosmetic grade raw material with the content of more than 98 percent.
Further, the whitening skin-care essence also comprises 60-98 parts of a cosmetic auxiliary material matrix, wherein the formula of the cosmetic auxiliary material matrix comprises the following raw material components in parts by weight:
furthermore, the cosmetic auxiliary material matrix comprises the following raw material components in parts by weight:
preferably, the skin conditioner of the present invention may be selected from one or a combination of two or more of triethanolamine, α -mannan, sodium hyaluronate, sodium pyrrolidone carboxylate, betaine, polyquaternium-51, levan, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, Chondrus CRISPUS extract, chitosan, β -glucan, creatine.
Preferably, the humectant can be selected from one or a combination of more than two of glycerin, propylene glycol, 1, 3-propylene glycol, butanediol, hexanediol, 1, 2-pentanediol, caprylyl glycol, allantoin, sorbitol, betaine and carbomer; the chelating agent can be one or the combination of more than two of EDTA disodium, EDTA tetrasodium, citric acid and sodium citrate; the thickening agent can be selected from one or the combination of more than two of acryloyl dimethyl ammonium taurate/VP copolymer, sodium polyacrylate, acrylic acid (ester) copolymer sodium, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, polyacrylate-13, acryloyl dimethyl ammonium taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, xanthan gum and carbomer; the emollient is selected from mineral oil, isohexadecane, shea butter, olive oil, polydimethylsiloxane, hydrogenated polyisobutene, caprylic/capric triglyceride, glycerol tri (ethyl hexanoate), squalane, ethylhexyl palmitate, hydrogenated polydecene, hydrogenated polyisobutene, cyclopenta dimethyl siloxane, and cyclohexasiloxane.
Another technical object of the present invention is to provide a method for preparing the whitening skin care essence, comprising the following steps:
1) weighing the following raw material components according to a formula: 1-3 parts of nicotinamide; 1-4 parts of whitening compound 1; 1-3 parts of whitening compound 2; 0.5-1.5 parts of citrus peel extract; 0.1-0.5 parts of arbutin; 1-40 parts of a humectant; 0.01-2.00 parts of chelating agent; 0.05-5.00 parts of thickening agent; 0.1-30.0 parts of an emollient; 0.01-40.00 parts of skin conditioner; 0.01-1.00 part of essence; 0.01-1.00 part of preservative; 0.01-1.00 part of solubilizer; a proper amount of water;
2) adding water, humectant, chelating agent and thickener into water phase pot, stirring, heating to 80-85 deg.C, and dispersing uniformly to obtain phase A;
3) adding emollient into oil phase pan, heating to 75-80 deg.C, stirring to obtain phase B;
4) pumping the phase A and the phase B into an emulsifying pot, homogenizing, stirring, cooling, adding skin conditioner, nicotinamide, whitening compound 1, whitening compound 2, citrus peel extract, arbutin, essence, solubilizer and antiseptic when the temperature is reduced to 40-45 deg.C, and homogenizing;
5) and continuing stirring, cooling to the temperature lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
Compared with the prior art, the invention has the beneficial effects that:
the whitening and skin-care essence formula with the synergistic whitening effect can avoid the phenomenon that the skin obtains negative feedback signals (melanin is reduced and melanin needs to be produced in large quantity) due to the sudden enhancement of signals of a certain whitening node. The whitening effect can be highlighted through the synergistic effect on a plurality of whitening key points, and the control can be performed on the nodes of the whole whitening chain, so that the skin system of a human body is harmonious, the generation and transmission of melanin are reduced, and the whitening and skin brightening effects are achieved.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention. Unless otherwise specified, the following parts by weight are in units of kilograms or kilograms.
Examples 1 to 3
First, formula
The whitening skin-care essence with the synergistic whitening effect in the embodiments 1-3 of the invention has the content of the raw material component ratio, the raw material component ratio in the comparative examples 1-5 and the blank component ratio shown in the following table 1.
TABLE 1 whitening skin care essence of examples 1-3, comparative examples 1-5 and blank example (unit: parts by weight)
The total weight of the whitening and skin-care essence formulas of examples 1-3, comparative examples 1-5 and blank examples is 100 parts by weight.
Preparation process of whitening and skin-care essence
The preparation process of the whitening skin-care essence comprises the following steps:
1) putting the deionized water of examples 1-3 in Table 1 into a water phase pot, adding carbomer and acryloyl dimethyl ammonium taurate/VP copolymer, stirring until the mixture is completely swelled, adding xanthan gum and hyaluronic acid pre-dispersed by 1.3-butanediol and glycerol, adding EDTA-2NA and allantoin, heating to 85 ℃, keeping the temperature, and stirring for 20 minutes to obtain phase A.
2) Adding polydimethylsiloxane and hydrogenated polyisobutene into an oil phase pot, heating to 80 ℃, and uniformly stirring to obtain a phase B.
3) Pumping the materials of phase A and phase B into an emulsifying pot, stirring and homogenizing for 3 minutes, starting cooling water, cooling to 65 ℃, adding triethanolamine, stirring and cooling to 45 ℃, and adding arbutin, nicotinamide, whitening compound 1, whitening compound 2, citrus peel extract, essence, solubilizer and preservative; stirring for 20 minutes, cooling to room temperature, and discharging after qualified inspection. The whitening and skin-care essence of comparative examples 1 to 5 and the blank examples were prepared according to the preparation methods of examples 1 to 3.
The formula and the content of the raw material components of the whitening compound 1 are shown in the following table 2; the formula and the content of the raw material components of the whitening compound 2 are shown in the following table 3.
Table 2 raw material component formulation of whitening complex 1 described in examples 1-3
Table 3 raw material component formulation of whitening complex 2 described in examples 1-3
| Component name | Content (parts by weight) |
| Water (W) | 41.5000 |
| Glycerol | 28.0000 |
| Sucrose dilaurate | 20.0000 |
| Polysorbate-20 | 5.0000 |
| Pea (Pisum SATIVUM) extract | 2.0000 |
| Phenoxyethanol | 2.0000 |
| Octylene glycol | 1.0000 |
| p-anisic acid | 0.3000 |
| Sorbic acid | 0.2000 |
Third, test example for effect verification (whitening evaluation)
1. The tester: 80 healthy women (25-45 years old) divided into 8 groups of 10 persons each; each group used the same formulation.
2. Test area: face (left face blank, right face control sample or example sample);
3. use of: twice a day in the morning and evening for 4 weeks
4. Testing an instrument: delfin SkinColorCatch (Finland)
5. The effect indexes are as follows: measuring the change in color lightness (. DELTA.L)*) ITA degree, L in the present invention*The values (brightness), ITA degrees (color individual type angle), are mainly used as indices.
Equation (1): Δ L*＝[L*(after 1 month of test on the control or example products) -L*(before starting the test)]-[L*(blank product after 1 month of testing) -L*(before starting the test)]
(2): ITA degree (representing the overall change of chromaticity, the larger the ITA degree value is, the lighter the skin color is.)
TABLE 4 ITA degree meanings
| ITA degree range | Skin color classification |
| 55-90 | Very shallow Very light |
| 41-54 | Light shallow |
| 28-40 | Intermediate, etc |
| 10-27 | Tanned tanning |
| -30-9 | Brown color of Brown |
| -90--29 | -29Dark color of Dark color |
5. The test results are shown in table 5 below:
TABLE 5 whitening test Effect tables of examples 1 to 3 and comparative examples 1 to 5
The results in table 5 show that the whitening skin-care essence disclosed in the embodiments 1 to 4 of the present invention has a significant whitening and skin-color-brightening effect compared to the comparative examples 1 to 5 through the synergistic effect between the raw material components, and the whitening skin-care essence has a more significant whitening and skin-color-brightening effect than a single whitening component.
Example 4
First, formula
The whitening and skin-care essence with the synergistic whitening effect in example 4 of the invention comprises the following raw material component ratios, the raw material component ratios of the comparative example and the contents of the blank example, as shown in table 6.
TABLE 6 whitening skin-care essence (unit: parts by weight) of example 4, comparative examples 6 to 15 and blank example
The total weight of the whitening and skin-care essence formulas of example 4, comparative examples 6 to 15 and blank examples is 100 parts by weight.
The preparation process of the whitening and skin-care essence in the embodiment 4 comprises the following steps:
1) putting deionized water into a water phase pot, adding carbomer and acryloyl dimethyl ammonium taurate/VP copolymer, stirring until swelling completely, adding xanthan gum and hyaluronic acid pre-dispersed with 1.3-butanediol and glycerol, adding EDTA-2NA and allantoin, heating to 85 deg.C, and stirring for 20 min under heat preservation.
2) Adding polydimethylsiloxane and hydrogenated polyisobutene into an oil phase pot, and heating to 80 ℃.
3) Pumping the materials in the water phase pot and the oil phase pot into an emulsifying pot, stirring and homogenizing for 3 minutes, starting cooling water, cooling to 65 ℃, adding triethanolamine, stirring and cooling to 45 ℃, and adding arbutin, nicotinamide, whitening compound 1, whitening compound 2, citrus peel extract, essence, solubilizer and preservative; stirring for 20 minutes, cooling to room temperature, and discharging after qualified inspection. The preparation processes of the whitening and skin-care essence of comparative examples 6 to 15 and the blank example were carried out according to the preparation process of example 4.
The formula and content of the raw material components of the whitening compound 1 and the whitening compound 2 described in example 4 are shown in tables 7 and 8.
Table 7 raw material component formulation for whitening complex 1
Table 8 raw material component formulation for whitening complex 2
| Component name | Content (parts by weight) |
| Water (W) | 41.5000 |
| Glycerol | 28.0000 |
| Sucrose dilaurate | 20.0000 |
| Polysorbate-20 | 5.0000 |
| Pea (pisumastivum) extract | 2.0000 |
| Phenoxyethanol | 2.0000 |
| Octylene glycol | 1.0000 |
| p-anisic acid | 0.3000 |
| Sorbic acid | 0.2000 |
Third, test example for effect verification (whitening evaluation)
1. The tester: 77 healthy women (25-45 years old) were divided into 11 groups of 7 persons each, each group using the same formula.
2. Test area: face (left face blank, right face control sample or example sample);
3. use of: twice a day in the morning and evening for 4 weeks
4. Testing an instrument: delfin SkinColorCatch (Finland)
5. The effect indexes are as follows: the change in color brightness (Δ L) and the ITA degree were measured, and the L value (brightness) and the ITA degree (color individual type angle) were mainly used as indices in the present invention.
Equation (1): Δ L*＝[L*(after 1 month of test on the control or example products) -L*(before starting the test)]-[L*(blank product after 1 month of testing) -L*(before starting the test)]
(2): ITA degree (representing the overall change of chromaticity, the larger the ITA degree value is, the lighter the skin color is.)
TABLE 9 ITA degree description
| ITA degree range | Skin color classification |
| 55-90 | Verylight is very shallow |
| 41-54 | Light shallow |
| 28-40 | Intermediate, etc |
| 10-27 | Tanned tanning |
| -30-9 | Brown color of Brown |
| -90--29 | -29Dark color of Dark color |
6. The test results are shown in table 10 below:
TABLE 10 whitening test of example 4, and comparative examples 6-15Effect table
As shown in the results in table 10, the whitening and skin-care essence disclosed in example 4 of the present invention has a relatively significant whitening and skin-lightening effect through the synergistic effect of the components, and has a more significant whitening effect than the whitening effect of the combination of two, three or four components.
Fourth, safety test
1. The number of tested persons: 30 persons in total, 3 men and 27 women; minimum age: 24 years old, maximum age: 45
The year of age; mean age 35.73 ± 7.15 years volunteer enrollment criteria.
2. The test method comprises the following steps: examples 1-4 were tested for patch. Selecting a qualified spot tester, placing about 0.020-0.025 mL of a tested object into the spot tester by using a closed spot test method, externally applying a medical adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions 0.5, 24 and 48 hours after the spot is removed, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
3. The evaluation criteria are as follows in table 11:
TABLE 11 grading Standard of adverse skin reactions
The results in table 11 show: the result of the human skin closed patch test shows that 30 people have the skin closed patch0Example (a)Positive forIn response, the test subjects were treated according to the protocol of technical Specification for cosmetic safety (2015 edition)Can notCausing adverse reactions to the skin.
Fifth, stability test
1. Stability test samples: example 4 whitening skin care essence product.
2. The test method comprises the following steps: the internal control standard (illumination for 1 month and high and low temperature test for 3 months) is higher than the national standard and the industrial standard.
3. The test results are shown in table 12 below.
Table 12 stability test results
The results of the whitening skin care essence product of example 4 by stability test are shown in table 12: the whitening skin care essence disclosed by the invention has good stability. In addition, the stability test results of the embodiments 1 to 3 are qualified and have better stability through the same test method.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (8)
1. The whitening skin-care essence with the synergistic whitening effect is characterized by comprising the following raw material components in parts by weight:
the whitening compound 1 comprises the following raw material components in parts by weight: 40-50 parts of water, 40-50 parts of butanediol, 0.3-0.8 part of arbutin, 0.3-0.6 part of citric acid, 0.4-0.6 part of sodium sulfite, 0.1-0.3 part of acetyl tyrosine, 0.01-0.30 part of strawberry saxifrage extract, 0.01-0.20 part of peony root extract, 0.001-0.100 part of aminopropanol ascorbic acid phosphate, 0.01-0.10 part of scutellaria root extract, 0.001-0.100 part of glutathione and 0.01-0.60 part of hydrolyzed cherry plum;
the whitening compound 2 comprises the following raw material components in parts by weight: 36.95-50.0 parts of water, 28-30 parts of glycerol, 20-22 parts of sucrose dilaurate, 5-6 parts of polysorbate-20, 2-3 parts of pea extract, 2-3 parts of phenoxyethanol, 1-2 parts of caprylyl glycol, 0.3-0.5 part of p-anisic acid and 0.2-0.3 part of sorbic acid.
2. The whitening skin-care essence according to claim 1, which is characterized by comprising the following components in parts by weight:
3. the whitening skin-care essence according to claim 1 or 2, wherein the nicotinic acid content of the nicotinamide is less than 100 PPM; the citrus peel extract is extracted by carbon dioxide supercritical extraction, and the content of total flavonoids is more than or equal to 2.5 percent; the arbutin is a cosmetic grade raw material with the content of more than 98 percent.
4. The whitening skin-care essence according to claim 1, further comprising 60-98 parts of a cosmetic auxiliary material matrix, wherein the formula of the cosmetic auxiliary material matrix comprises the following raw material components in parts by weight:
5. the whitening skin-care essence according to claim 4, wherein the cosmetic auxiliary material matrix comprises the following raw material components in parts by weight:
6. the whitening skin-care essence according to claim 4 or 5, wherein the skin conditioner is one or more of triethanolamine, α -mannan, sodium hyaluronate, sodium pyrrolidone carboxylate, betaine, polyquaternium-51, levan, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, Chondrus crispus extract, chitosan, β -glucan, and creatine.
7. The whitening skin-care essence according to claim 4 or 5, wherein the humectant is one or more selected from glycerin, propylene glycol, 1, 3-propylene glycol, butylene glycol, hexylene glycol, 1, 2-pentanediol, caprylyl glycol, allantoin, sorbitol, and betaine; the chelating agent is one or the combination of more than two of disodium EDTA, tetrasodium EDTA, citric acid and sodium citrate; the thickening agent is selected from one or the combination of more than two of acryloyl dimethyl taurate/VP copolymer, sodium polyacrylate, acrylic acid (ester) copolymer sodium, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, polyacrylate-13, acryloyl dimethyl taurate ammonium/behenyl alcohol polyether-25 methacrylate cross-linked polymer, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, xanthan gum and carbomer; the emollient is selected from one or more of mineral oil, isohexadecane, shea butter, olive oil, polydimethylsiloxane, caprylic/capric triglyceride, tri (ethyl hexanoate) glyceride, squalane, ethylhexyl palmitate, hydrogenated polydecene, hydrogenated polyisobutene, cyclopenta dimethyl siloxane, and cyclohexasiloxane.
8. The preparation method of the whitening skin-care essence is characterized by comprising the following steps:
1) weighing the following raw material components according to a formula: 1-3 parts of nicotinamide; 1-4 parts of whitening compound 1; 1-3 parts of whitening compound 2; 0.5-1.5 parts of citrus peel extract; 0.1-0.5 parts of arbutin; 1-40 parts of a humectant; 0.01-2.00 parts of chelating agent; 0.05-5.00 parts of thickening agent; 0.1-30.0 parts of an emollient; 0.01-40.00 parts of skin conditioner; 0.01-1.00 part of essence; 0.01-1.00 part of preservative; 0.01-1.00 part of solubilizer and water;
2) adding water, humectant, chelating agent and thickener into water phase pot, stirring, heating to 80-85 deg.C, and dispersing uniformly to obtain phase A;
3) adding emollient into oil phase pan, heating to 75-80 deg.C, stirring to obtain phase B;
4) pumping the phase A and the phase B into an emulsifying pot, homogenizing, stirring, cooling, adding skin conditioner, nicotinamide, whitening compound 1, whitening compound 2, citrus peel extract, arbutin, essence, solubilizer and antiseptic when the temperature is reduced to 40-45 deg.C, and homogenizing;
5) continuing stirring, cooling to a temperature lower than 38 ℃, stopping stirring, and discharging after the detection is qualified;
the whitening compound 1 comprises the following raw material components in parts by weight: 40-50 parts of water, 40-50 parts of butanediol, 0.3-0.8 part of arbutin, 0.3-0.6 part of citric acid, 0.4-0.6 part of sodium sulfite, 0.1-0.3 part of acetyl tyrosine, 0.01-0.30 part of strawberry saxifrage extract, 0.01-0.20 part of peony root extract, 0.001-0.100 part of aminopropanol ascorbic acid phosphate, 0.01-0.10 part of scutellaria root extract, 0.001-0.100 part of glutathione and 0.01-0.60 part of hydrolyzed cherry plum; the whitening compound 2 comprises the following raw material components in parts by weight: 36.95-50.0 parts of water, 28-30 parts of glycerol, 20-22 parts of sucrose dilaurate, 5-6 parts of polysorbate-20, 2-3 parts of pea extract, 2-3 parts of phenoxyethanol, 1-2 parts of caprylyl glycol, 0.3-0.5 part of p-anisic acid and 0.2-0.3 part of sorbic acid.
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| CN115068391B (en) * | 2022-08-05 | 2024-01-26 | 维怡美生物科技(广州)有限公司 | Whitening composition, whitening essence containing same and whitening water |
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| CN105411931A (en) * | 2015-12-09 | 2016-03-23 | 上海新高姿化妆品有限公司 | Whitening cosmetic composition |
| WO2017102589A1 (en) * | 2015-12-14 | 2017-06-22 | Dsm Ip Assets B.V. | Composition comprising niacinamide and alpha-arbutin for skin lightening |
| CN107281024A (en) * | 2017-06-26 | 2017-10-24 | 上海新高姿化妆品有限公司 | It is a kind of that there is cosmetic composition of collaboration whitening effect and preparation method thereof |
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