CN115068391B - Whitening composition, whitening essence containing same and whitening water - Google Patents
Whitening composition, whitening essence containing same and whitening water Download PDFInfo
- Publication number
- CN115068391B CN115068391B CN202210936826.3A CN202210936826A CN115068391B CN 115068391 B CN115068391 B CN 115068391B CN 202210936826 A CN202210936826 A CN 202210936826A CN 115068391 B CN115068391 B CN 115068391B
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- whitening
- whitening composition
- water
- extract
- composition
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 168
- 239000000203 mixture Substances 0.000 title claims abstract description 93
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 45
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000003906 humectant Substances 0.000 claims abstract description 23
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 20
- 229960000458 allantoin Drugs 0.000 claims abstract description 20
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 20
- 239000003755 preservative agent Substances 0.000 claims abstract description 18
- 230000002335 preservative effect Effects 0.000 claims abstract description 18
- 239000001575 punica granatum l. bark extract Substances 0.000 claims abstract description 13
- GVWGRUCKLWVZRY-ATDBAKNUSA-N (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N.COC1=CC(\C=C\C(O)=O)=CC=C1O GVWGRUCKLWVZRY-ATDBAKNUSA-N 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 230000032683 aging Effects 0.000 claims abstract description 9
- 239000002738 chelating agent Substances 0.000 claims abstract description 9
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 241000499563 Eimeria necatrix Species 0.000 claims abstract description 6
- 244000141359 Malus pumila Species 0.000 claims abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 14
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 13
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 235000011201 Ginkgo Nutrition 0.000 claims description 9
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 7
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 7
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 7
- 229920002079 Ellagic acid Polymers 0.000 claims description 7
- 108010024636 Glutathione Proteins 0.000 claims description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 7
- 229960003237 betaine Drugs 0.000 claims description 7
- 229960002852 ellagic acid Drugs 0.000 claims description 7
- 235000004132 ellagic acid Nutrition 0.000 claims description 7
- 229960003180 glutathione Drugs 0.000 claims description 7
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 7
- 229940073490 sodium glutamate Drugs 0.000 claims description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 229960003966 nicotinamide Drugs 0.000 claims description 3
- 235000005152 nicotinamide Nutrition 0.000 claims description 3
- 239000011570 nicotinamide Substances 0.000 claims description 3
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 34
- 230000008591 skin barrier function Effects 0.000 abstract description 23
- 230000009286 beneficial effect Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 9
- 210000003491 skin Anatomy 0.000 description 37
- 230000000052 comparative effect Effects 0.000 description 13
- 241000220225 Malus Species 0.000 description 10
- 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 description 10
- 241000218628 Ginkgo Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000013329 compounding Methods 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 230000001804 emulsifying effect Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 229940015975 1,2-hexanediol Drugs 0.000 description 3
- 241001071917 Lithospermum Species 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 description 2
- 241000130781 Arnebia Species 0.000 description 2
- 241000219991 Lythraceae Species 0.000 description 2
- 235000014360 Punica granatum Nutrition 0.000 description 2
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229960003993 chlorphenesin Drugs 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000036564 melanin content Effects 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- 229940035437 1,3-propanediol Drugs 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 244000058084 Aegle marmelos Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the field of skin care products, and particularly discloses a whitening composition, and whitening essence and whitening water containing the composition. The whitening composition comprises the following components: extract of radix Arnebiae; an extract of Eimeria necatrix; pomegranate peel extract; apple root extract; and (3) a solvent. The whitening essence containing the whitening composition comprises the following components: a whitening composition; arginine ferulate; 1-methylhydantoin-2-imide; allantoin; a humectant; a preservative; a thickener; a pH regulator; a chelating agent; and (3) water. The whitening water containing the whitening composition comprises the following components: a whitening composition; allantoin; a humectant; a preservative; and (3) water. The preparation method comprises the following steps: and uniformly mixing the components, filtering and aging to obtain the corresponding product. The composition disclosed by the invention is beneficial to better removing melanin and is not easy to influence the skin barrier; the preparation method of the invention is beneficial to better synergy and better function of each component.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a whitening composition, and whitening essence and whitening water containing the composition.
Background
In common telephone, one hides three ugly. And loves the heart, people are all right, so that white and transparent complexion is always pursued by a plurality of women.
There are also many whitening products on the market at present, some of which are capable of whitening by inhibiting the generation of melanin, some of which are capable of whitening by blocking the transmission of melanin, and some of which are capable of enabling the cells of the horny layer to fall off by accelerating metabolism, so that the melanin on the skin surface falls off along with the horny layer at the same time.
However, products that cause exfoliation of the stratum corneum by accelerating skin metabolism are also susceptible to damage to the skin, causing damage to the skin's barrier, and may even be susceptible to other skin problems, and thus there is room for improvement.
Disclosure of Invention
In order to better reconstruct the skin barrier while accelerating the metabolism of the skin and accelerating the exfoliation of the horny layer, the present application provides a whitening composition and whitening essence and whitening water containing the same.
In a first aspect, the present application provides a whitening composition, which adopts the following technical scheme:
the whitening composition comprises the following components in parts by weight:
0.05-0.2 part of ginkgo radix arnebiae root extract;
0.07-0.3 part of Eimeria necatrix extract;
0.3-0.8 part of pomegranate peel extract;
apple root extract 0.5-1 parts;
4-6 parts of solvent.
The addition of the shikonin root extract and the paecilomyces farnesii extract is beneficial to enhancing the metabolism of the skin and accelerating the falling of the stratum corneum of the skin, thereby being beneficial to accelerating the removal of melanin and having better whitening effect; meanwhile, the radix ginkgo extract and the paecilomyces farnesii extract are favorable for better inhibiting the activity of tyrosinase, so that melanin generation is reduced; the addition of the pomegranate peel extract is also beneficial to better inhibiting the activity of melanin, so that the transmission of the melanin is also influenced, the whitening effect is better due to the fact that the whitening effect is realized in an omnibearing manner.
By adding the pomegranate peel extract and the apple root extract, and the ginkgo radix arnebiae extract and the paecilomyces fargesii extract for synergistic compounding, the damage to the skin barrier caused by the ginkgo radix arnebiae extract and the paecilomyces fargesii extract when promoting the metabolism of the skin is better relieved, the repair of the skin barrier is accelerated, the skin is less sensitive, the whitening effect is better improved, and the skin barrier is better reconstructed.
Preferably, the composition further comprises the following components in parts by weight:
3-5 parts of nicotinamide.
By adding nicotinamide, the content of ceramide in the stratum corneum is favorably increased, so that the function of skin barrier is favorably further enhanced, and the skin is less susceptible to becoming sensitive or skin problems; meanwhile, the nicotinamide also has an excellent whitening effect, so that the whitening effect of the whitening composition is further improved.
Preferably, the composition further comprises the following components in parts by weight:
ellagic acid 0.01-0.05 part;
glutathione 0.01-0.03 parts.
The addition of ellagic acid and glutathione for synergistic compounding is also beneficial to further inhibiting the activity of tyrosinase, thereby blocking the generation of melanin and leading the whitening effect of the whitening composition to be better.
In a second aspect, the present application provides a whitening essence containing the above whitening composition, which adopts the following technical scheme:
the whitening essence containing the whitening composition comprises the following components in percentage by weight:
10-12% of a whitening composition;
arginine ferulate 0.3-0.5%;
1-1.5% of 1-methyl hydantoin-2-imide;
allantoin 0.1-0.3%;
7-10% of humectant;
0.2-0.5% of preservative;
0.1-0.3% of thickener;
0.1-0.3% of pH regulator;
0.05-0.12% of chelating agent;
the balance being water.
Arginine ferulate, 1-methyl hydantoin-2-imide and allantoin are compounded to be used as skin conditioning agents, and are matched with a whitening composition to prepare whitening essence, so that the whitening effect of the whitening composition is better promoted, and meanwhile, the repair of a skin barrier is better accelerated, so that the skin is less susceptible.
Preferably, the humectant is prepared by mixing butanediol, glycerol polyether-26 and sodium hyaluronate according to the mass ratio of 80:80:0.5-1.
The skin moisture is better supplemented by adopting the synergistic compounding of the butanediol, the glycerol polyether-26 and the sodium hyaluronate in a specific proportion as the humectant, so that the repair of the skin barrier is further accelerated, and the skin is less sensitive.
In a third aspect, the present application provides a method for preparing a whitening essence containing a whitening composition, which adopts the following technical scheme:
a preparation method of whitening essence containing a whitening composition comprises the following steps:
step 1, mixing water, humectant, arginine ferulate, 1-methyl hydantoin-2-imide, allantoin, thickener and chelating agent, stirring uniformly, heating to 80-85 ℃, and preserving heat for 18-22min;
and step 2, gradually reducing the temperature, adding the preservative, the pH regulator and the whitening composition when the temperature is reduced to 35-40 ℃, uniformly stirring, filtering, and standing and aging for 24-26 hours to obtain the whitening essence containing the whitening composition.
By controlling the mixing sequence and the mixing temperature of the components, the components are better cooperated and compounded and act, so that the whitening effect of the whitening essence and the effect of synchronously repairing the skin barrier are better improved.
In a fourth aspect, the present application provides a whitening water containing the above whitening composition, which adopts the following technical scheme:
the whitening water containing the whitening composition comprises the following components in percentage by mass:
10-12% of a whitening composition;
allantoin 0.1-0.3%;
6-9% of humectant;
0.05-0.1% of preservative;
the balance being water.
The allantoin is used as a skin conditioner and is compounded with the whitening composition to prepare whitening water, so that the whitening effect of the whitening composition is better promoted, and meanwhile, the repair of a skin barrier is better quickened, so that the skin is less sensitive.
Preferably, the humectant is compounded by butanediol, 1, 3-propylene glycol, poly-gamma-sodium glutamate and betaine.
The synergistic compounding of butanediol, 1, 3-propylene glycol, poly-gamma-sodium glutamate and betaine is adopted as the humectant, so that the skin moisture can be better supplemented, the repair of the skin barrier can be further accelerated, and the skin is less sensitive.
In a fifth aspect, the present application provides a method for preparing whitening water containing a whitening composition, which adopts the following technical scheme:
a preparation method of whitening water containing a whitening composition comprises the following steps:
step 1, mixing water, butanediol, 1, 3-propylene glycol, betaine and allantoin, stirring uniformly, heating to 80-85 ℃, and preserving heat for 15-20min;
and step 2, gradually reducing the temperature, continuously adding the poly-gamma-sodium glutamate, the preservative and the whitening composition when the temperature is reduced to 35-40 ℃, uniformly stirring, filtering, and standing and aging for 24-26 hours to obtain the whitening water containing the whitening composition.
By controlling the mixing sequence and the mixing temperature of the components, the components are better cooperated and compounded and act, so that the whitening effect of the whitening water and the effect of synchronously repairing the skin barrier are better improved.
In summary, the present application has the following beneficial effects:
1. the addition of the shikonin root extract, the paecilomyces farnesii extract and the pomegranate peel extract for compounding is beneficial to enhancing the metabolism of the skin, so that the melanin removal is accelerated; it is also advantageous to better inhibit tyrosinase activity, thereby facilitating reduced melanin production; and the method is also beneficial to better inhibiting the activity of melanin, so that the transmission of the melanin is also influenced, and the whitening effect is better due to the fact that the whitening is realized in an omnibearing manner.
2. By adding the pomegranate peel extract and the apple root extract and the ginkgo lithospermum root extract and the paecilomyces polymorpha extract for synergistic compounding, the repair of the skin barrier is quickened, the skin is less susceptible, the whitening effect is better improved, and the skin barrier is better reconstructed.
3. Arginine ferulate, 1-methyl hydantoin-2-imide and allantoin are compounded to be used as skin conditioning agents, and are matched with a whitening composition to prepare whitening essence, so that the whitening effect of the whitening composition is better promoted, and meanwhile, the repair of a skin barrier is better accelerated, so that the skin is less susceptible.
4. The allantoin is used as a skin conditioner and is compounded with the whitening composition to prepare whitening water, so that the whitening effect of the whitening composition is better promoted, and meanwhile, the repair of a skin barrier is better quickened, so that the skin is less sensitive.
Detailed Description
The present application is described in further detail below with reference to examples.
Example 1
The embodiment of the application discloses a whitening composition which comprises the following components in parts by mass:
0.05kg of ginkgo radix arnebiae extract; 0.07kg of Eimeria necatrix extract; 0.3kg of pomegranate peel extract; apple root extract 0.5kg; 4kg of solvent.
In this example, the solvent was composed of 1, 2-hexanediol, butanediol, 1, 2-pentanediol, and water at 1:26:1:200 by mass ratio.
The embodiment of the application also discloses a preparation method of the whitening composition, which comprises the following steps:
and accurately weighing the components according to the mass at normal temperature, and uniformly mixing and stirring to obtain the whitening composition.
Example 2
The difference from example 1 is that:
the dosage proportion of each component is different, and the concrete steps are as follows:
0.2kg of ginkgo radix arnebiae extract; 0.3kg of an extract of Eimeria necatrix; 0.8kg of pomegranate peel extract; 1kg of apple root extract; 6kg of solvent.
Example 3
The difference from example 1 is that:
the dosage proportion of each component is different, and the concrete steps are as follows:
0.1kg of ginkgo radix arnebiae extract; 0.2kg of the Eimeria necatrix extract; 0.5kg of pomegranate peel extract; apple root extract 0.8kg; 5kg of solvent.
Example 4
The difference from example 3 is that: the whitening composition further comprises 3kg nicotinamide, 0.01kg ellagic acid and 0.01kg glutathione.
Example 5
The difference from example 3 is that: the whitening composition further comprises 5kg nicotinamide, 0.05kg ellagic acid and 0.03kg glutathione.
Example 6
The difference from example 3 is that: the whitening composition further comprises 4kg nicotinamide, 0.03kg ellagic acid and 0.02kg glutathione.
Comparative example 1
The difference from example 3 is that: the extract of pomegranate peel and apple root is replaced by the same amount of solvent.
Comparative example 2
The difference from example 3 is that: the extract of pomegranate peel was replaced with an equal amount of solvent.
Comparative example 3
The difference from example 3 is that: the stone apple root extract was replaced with an equal amount of solvent.
Experimental example 1
The experimental example discloses a whitening essence containing a whitening composition, which comprises the following components in mass:
10kg of a whitening composition; arginine ferulate 0.3kg; 1kg of 1-methylhydantoin-2-imide; allantoin 0.1kg; 7kg of humectant; 0.2kg of preservative; 0.1kg of thickener; 0.1kg of pH regulator; 0.05kg of chelating agent; 81.15kg of water.
In this experimental example, the whitening composition was the whitening composition prepared in example 1; the humectant is prepared by mixing butanediol, glycerol polyether-26 and sodium hyaluronate according to the mass ratio of 80:80:0.5; the preservative consists of phenoxyethanol, 1, 2-hexanediol and chlorphenesin ether with a weight ratio of 52.5:25:22.5, uniformly mixing the materials according to the mass ratio; the thickener is carbomer; the pH regulator is arginine; the chelating agent is disodium EDTA.
The experimental example also discloses a preparation method of the whitening essence containing the whitening composition, which comprises the following steps:
step 1, cleaning an emulsifying pot and other production equipment, adding water, humectant, arginine ferulate, 1-methyl hydantoin-2-imide, allantoin, thickener and chelating agent into the emulsifying pot, homogenizing and stirring for 15min, uniformly mixing, heating to 80 ℃, and preserving heat for 22min.
And step 2, gradually reducing the temperature in the emulsifying pot under natural conditions, continuously adding the preservative, the pH regulator and the whitening composition when the temperature is reduced to 35 ℃, stirring and mixing uniformly, filtering and discharging, taking filtrate, standing and aging for 24 hours, and obtaining the whitening essence containing the whitening composition.
Experimental example 2
The difference from experimental example 1 is that: whitening composition the whitening composition prepared in example 2 was used.
Experimental example 3
The difference from experimental example 1 is that: whitening composition the whitening composition prepared in example 3 was used.
Experimental example 4
The difference from experimental example 1 is that: whitening composition the whitening composition prepared in example 4 was used.
Experimental example 5
The difference from experimental example 1 is that: whitening composition the whitening composition prepared in example 5 was used.
Experimental example 6
The difference from experimental example 1 is that: whitening composition the whitening composition prepared in example 6 was used.
Experimental example 7
The difference from experimental example 1 is that:
the dosage of each component is different, and the specific steps are as follows:
12kg of a whitening composition; arginine ferulate 0.5kg; 1.5kg of 1-methylhydantoin-2-imide; allantoin 0.3kg; 10kg of humectant; 0.5kg of preservative; 0.3kg of thickener; 0.3kg of pH regulator; 0.12kg of chelating agent; 74.48kg of water.
In the experimental example, the humectant is prepared by mixing butanediol, glycereth-26 and sodium hyaluronate in a mass ratio of 80:80:1.
In the preparation of the whitening essence, in the step 1, heating to 85 ℃, and preserving heat for 18min; in the step 2, when the temperature is reduced to 40 ℃, adding the rest substances, and finally standing and aging for 26 hours to obtain the whitening essence containing the whitening composition.
Experimental example 8
The experimental example discloses whitening water containing a whitening composition, which comprises the following components in mass:
10kg of a whitening composition; allantoin 0.1kg; 6kg of humectant; 0.05kg of preservative; 84.85kg of water.
In this experimental example, the whitening composition was the whitening composition prepared in example 1; the humectant is prepared from butanediol, 1, 3-propylene glycol, poly gamma-sodium glutamate and betaine in a proportion of 3:3.6:0.2:0.5 mass ratio; the preservative consists of phenoxyethanol, 1, 2-hexanediol and chlorphenesin ether with a weight ratio of 52.5:25:22.5 mass ratio.
The experimental example also discloses a preparation method of the whitening water containing the whitening composition, which comprises the following steps:
step 1, cleaning an emulsifying pot and other production equipment, adding water, butanediol, 1, 3-propanediol, betaine and allantoin into the emulsifying pot, homogenizing and stirring for 15min, uniformly mixing, heating to 80 ℃, and preserving heat for 20min.
And step 2, gradually reducing the temperature in the emulsifying pot under natural conditions, continuously adding the poly-gamma-sodium glutamate, the preservative and the whitening composition when the temperature is reduced to 35 ℃, stirring and mixing uniformly, filtering and discharging, taking filtrate, standing and aging for 24 hours, and obtaining the whitening water containing the whitening composition.
Experimental example 9
The difference from experimental example 8 is that:
the dosage of each component is different, and the specific steps are as follows:
12kg of a whitening composition; allantoin 0.3kg; 8kg of humectant; 0.1kg of preservative; 79.6kg of water.
In the preparation of the whitening water, in the step 1, heating to 85 ℃, and preserving heat for 15min; in the step 2, when the temperature is reduced to 40 ℃, adding the rest substances, and finally standing and aging for 26 hours to obtain the whitening water containing the whitening composition.
Comparative experiment example 1
The difference from experimental example 1 is that: the whitening composition was the whitening composition prepared in comparative example 1.
Comparative experiment example 2
The difference from experimental example 1 is that: the whitening composition was the whitening composition prepared in comparative example 2.
Comparative experiment example 3
The difference from experimental example 1 is that: the whitening composition was the whitening composition prepared in comparative example 3.
Blank control group
The difference from experimental example 1 is that: the whitening composition was replaced with an equivalent amount of humectant.
Experiment 1
130 female volunteers of similar skin tone were randomly selected, aged 25-55 years, and the volunteers were randomly divided into 13 groups of 10 persons each. The volunteers respectively and correspondingly use the whitening essence or the whitening water prepared by the experimental example, the comparative experimental example and the blank control group after face cleaning in the morning and evening, the whitening essence or the whitening water is uniformly smeared on cheeks at two sides, the usage amount of each time is 5g, the skin care product is continuously used for 28 days, and no other skin care products are used in the test process. Skin melanin content (MI value) of volunteers before, after 7 days, after 15 days, and after 28 days of use was measured using a melanin tester from CK company in germany. The average of the test results of the volunteers of the same group was calculated and recorded.
Among them, the lower the measured melanin content (MI value), the less melanin the skin contains, and the brighter the skin is.
Experiment 2
After volunteers continuously use for 28 days, salicylic acid is added into the whitening essence or the whitening water prepared in the experimental example, the comparative experimental example and the blank control group, the addition amount of the salicylic acid is 0.5% of the mass of the whitening essence or the whitening water, after uniform mixing, the volunteers respectively take 1g of the whitening essence or the whitening water corresponding to each group after adding the salicylic acid, uniformly apply the whitening essence or the whitening water on the left cheek, and record the number and the condition of people with skin itch or allergy in each group.
The test data of the above experiment are shown in Table 1.
TABLE 1
According to the comparison of the data of the hollow white control group and the data of the comparison experimental example 1 in the table 1, the white control group and the data of the comparison experimental example 1 are obtained, and by adding the radix arnebiae seu lithospermi extract and the paecilomyces farinae extract simultaneously for synergistic compounding, although the whitening effect of the whitening composition is better improved to a certain extent, the content of melanin in the skin is reduced, the melanin is removed, and meanwhile, the skin barrier is easily damaged, so that the skin is easily itchy or allergic when the skin is subjected to slight stimulus.
According to the data comparison of comparative experimental examples 1 to 3 in table 1, by adding apple root extract, while being advantageous to slightly alleviating damage of the extract of arnebia root and extract of paecilomyces meretricis on skin barrier to some extent, the whitening effect of the extract of arnebia root and extract of paecilomyces meretricis is slightly affected at the same time; the addition of the pomegranate peel extract is favorable for further inhibiting the activity of tyrosinase, so that the whitening effect of the whitening composition is better, but the skin barrier is damaged to a certain extent, and the skin is more sensitive easily.
According to the comparison of the data of the experimental example 1 and the data of the comparative experimental examples 1-3 in the table 1, the damage of the radix arnebiae seu lithospermi extract and the paecilomyces farnesii extract on the skin barrier in the process of removing melanin can not be relieved by independently adding the apple root extract or by independently adding the pomegranate peel extract, and the skin barrier is not easily reconstructed while the whitening effect of the whitening composition is better promoted only by adopting the synergistic effect of the apple root extract and the pomegranate peel extract, so that the skin is not easily affected by itch or red swelling when being slightly stimulated.
According to the data comparison of experimental examples 3 to 6 in table 1, the whitening effect of the whitening composition is further promoted by adding nicotinamide, ellagic acid and glutathione, and at the same time, the skin barrier reconstruction is not easily affected, so that the skin is not easily itchy or red and swollen when being slightly stimulated.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (4)
1. The whitening essence is characterized by comprising the following components in percentage by mass:
10-12% of a whitening composition;
arginine ferulate 0.3-0.5%;
1-1.5% of 1-methyl hydantoin-2-imide;
allantoin 0.1-0.3%;
7-10% of humectant;
0.2-0.5% of preservative;
0.1-0.3% of thickener;
0.1-0.3% of pH regulator;
0.05-0.12% of chelating agent;
the balance being water;
the humectant is prepared by mixing butanediol, glycerol polyether-26 and sodium hyaluronate according to the mass ratio of 80:80:0.5-1;
the whitening composition comprises the following components in parts by weight:
0.05-0.2 part of ginkgo radix arnebiae root extract;
0.07-0.3 part of Eimeria necatrix extract;
0.3-0.8 part of pomegranate peel extract;
apple root extract 0.5-1 parts;
4-6 parts of a solvent;
3-5 parts of nicotinamide;
ellagic acid 0.01-0.05 part; glutathione 0.01-0.03 parts.
2. A method for preparing the whitening essence according to claim 1, wherein: the method comprises the following steps:
step 1, mixing water, humectant, arginine ferulate, 1-methyl hydantoin-2-imide, allantoin, thickener and chelating agent, stirring uniformly, heating to 80-85 ℃, and preserving heat for 18-22min;
and step 2, gradually reducing the temperature, adding the preservative, the pH regulator and the whitening composition when the temperature is reduced to 35-40 ℃, uniformly stirring, filtering, and standing and aging for 24-26 hours to obtain the whitening essence containing the whitening composition.
3. The whitening water is characterized in that: comprises the following components in percentage by mass:
10-12% of the whitening composition of claim 1;
allantoin 0.1-0.3%;
6-9% of humectant;
0.05-0.1% of preservative;
the balance being water;
the humectant is compounded by butanediol, 1, 3-propylene glycol, poly-gamma-sodium glutamate and betaine.
4. A method of preparing the whitening water as set forth in claim 3, wherein: the method comprises the following steps:
step 1, mixing water, butanediol, 1, 3-propylene glycol, betaine and allantoin, stirring uniformly, heating to 80-85 ℃, and preserving heat for 15-20min;
and step 2, gradually reducing the temperature, continuously adding the poly-gamma-sodium glutamate, the preservative and the whitening composition when the temperature is reduced to 35-40 ℃, uniformly stirring, filtering, and standing and aging for 24-26 hours to obtain the whitening water containing the whitening composition.
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