CN114983906A - Repairing composition, and repairing cream and repairing water containing same - Google Patents

Repairing composition, and repairing cream and repairing water containing same Download PDF

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Publication number
CN114983906A
CN114983906A CN202210803715.5A CN202210803715A CN114983906A CN 114983906 A CN114983906 A CN 114983906A CN 202210803715 A CN202210803715 A CN 202210803715A CN 114983906 A CN114983906 A CN 114983906A
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extract
repairing
composition
skin
repair
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高德爱
殷运华
马兴
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Guangzhou Shouyang Pharmaceutical Biotechnology Co ltd
Guangzhou Xilisha Biotechnology Co ltd
Weiyimei Biotechnology Guangzhou Co ltd
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Guangzhou Shouyang Pharmaceutical Biotechnology Co ltd
Guangzhou Xilisha Biotechnology Co ltd
Weiyimei Biotechnology Guangzhou Co ltd
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Priority to CN202210803715.5A priority Critical patent/CN114983906A/en
Publication of CN114983906A publication Critical patent/CN114983906A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9722Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/524Preservatives
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    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to the field of skin care products, and particularly discloses a repairing composition, and repairing cream and repairing water containing the repairing composition. Wherein the repairing composition comprises the following components: (ii) a feverfew extract; a cornflower extract; extracts of France helichrysum; gentiana triflora extract; flos Sophorae Immaturus extract; chlorella extract; a linseed extract; quinoa seed extract; dendrobium nobile extract; a kelp extract; yeast fermentation lysate filtrate; and (3) a solvent. The composition has the advantage of quickly repairing skin injury caused by fruit acid skin change.

Description

Repairing composition, and repairing cream and repairing water containing same
Technical Field
The invention relates to the field of skin care products, in particular to a repairing composition, and repairing cream and repairing water containing the same.
Background
As people age gradually, most women suffer from various problems on their skin, such as freckles, etc., which are the most common problems. In general terms, it is good for the heart and people. These skin problems all cause significant damage to the personal image of the female. However, the skin care by using tartaric acid is a relatively popular beauty treatment method as a method for rapidly solving skin problems.
The skin is changed by the fruit acid, namely the fruit acid is smeared on the surface of the skin to lead the stratum corneum on the surface to generate corrosive spalling, and then the skin of the organism is promoted to be restored again, which is equivalent to the skin is changed once, so that some spots, deep spots and pockmarks existing on the skin can be restored again, and obvious fading occurs.
However, since tartaric acid is a slightly corrosive liquid, the stratum corneum of the skin is damaged after the skin is changed with tartaric acid, so that the skin becomes very fragile and slightly red and swollen, and if the subsequent skin care is not performed well, the skin may even become infected. Therefore, the development of the skin injury which can be quickly repaired and is caused by the skin change of the fruit acid has extremely important significance.
Disclosure of Invention
In order to better and more quickly repair skin damage caused by fruit acid skin change, the application provides a repair composition and a repair cream and repair water containing the same.
In a first aspect, the present application provides a repairing composition, which adopts the following technical scheme:
the repairing composition comprises the following components in parts by weight:
0.03-0.06 part of feverfew extract;
0.003 to 0.008 portion of cornflower extract;
0.02-0.07 part of French helichrysum extract;
0.03-0.08 part of gentiana trifoliata extract;
0.03-0.08 part of sophora flower bud extract;
0.05-0.1 part of chlorella extract;
0.05-0.1 part of linseed extract;
quinoa seed extract 0.01-0.05 part;
0.1-0.3 parts of dendrobium nobile lindl extract;
0.01-0.05 part of giant kelp extract;
4-7 parts of yeast fermentation lysate filtrate;
5-8 parts of a solvent.
The feverfew extract, the cornflower extract, the French wintersweet extract and the gentiana trilobata extract are adopted to form the tri-chrysanthemum anti-allergic agent in a synergistic manner, so that the tri-chrysanthemum anti-allergic agent is beneficial to enhancing the resistance of capillary vessels and inhibiting the permeability of the capillary vessels, the skin is less prone to allergy, and the anti-inflammatory effect is better improved.
By adopting the synergistic effect of the quinoa seed extract, the dendrobium nobile extract and the kelp extract, the immune system of the skin can be better regulated, the content of white blood cells of the skin can be increased, so that the skin itch can be better relieved, and the skin is less prone to secondary damage caused by scratching due to itch.
The yeast fermentation lysate filtrate is added, so that the regeneration of skin cells is promoted better, the withered and thinned skin is thickened, the growth of vascular endothelium is enhanced, the elasticity of blood vessels is improved, the expanded blood vessels are reset, the speed of skin repair is accelerated, and the speed of skin regrowth is higher.
The multiple substances are compounded in a specific ratio, so that the deep water replenishing of the skin is facilitated, the skin is not easy to have the condition of dryness and pruritus, the skin vitality is facilitated to be improved, and the fragile state of the skin is improved; meanwhile, the skin barrier can be repaired better and faster, so that the skin has stronger capability of resisting external pollution, and the secondary damage to the skin is reduced; in addition, the skin regeneration promoting agent is also beneficial to promoting the regeneration of skin cells, so that the repair and regeneration speed of the skin is higher, the complete repair time of the skin is favorably shortened, and the probability of skin infection is greatly reduced.
Preferably, the repairing composition further comprises the following components in parts by mass:
0.5-1.5 parts of tetrahydro-methyl-pyrimidine carboxylic acid.
By adding the tetrahydro-methyl pyrimidine carboxylic acid, the unique molecular structure of the tetrahydro-methyl pyrimidine carboxylic acid has strong water molecule complexing capacity, and free water in cells can be structured, so that the skin can be supplemented with water better and deeply, the activity of the skin is improved, and the secondary infection is not easy to occur.
Preferably, the repairing composition further comprises the following components in parts by mass:
0.01-0.03 part of preservative.
By adding the preservative, the shelf life of the composition is prolonged better, so that the composition is less prone to poor efficacy caused by the influence of the external environment.
Preferably, the preservative comprises one or more of p-hydroxyacetophenone, chlorophenyl glycoside ether and methyl hydroxybenzoate.
Preferably, the preservative is prepared by compounding p-hydroxyacetophenone, chlorphenesin and methylparaben in a mass ratio of 2-2.5:1: 1.
By adopting the compounding of substances in a specific ratio as the preservative, the preservative effect of the composition is favorably improved, and simultaneously the influence on the mildness of the composition is not easily caused, so that the composition is not easily influenced on the skin to cause secondary damage.
Preferably, the solvent comprises one or more of water, 1, 2-hexanediol, butanediol, glycerol.
By adopting the compounding of various substances as a solvent, the dissolving performance of each substance can be better improved, the substances can be better dissolved, and the mutual synergistic effect can be better exerted, so that the effect of the composition can be better improved.
In a second aspect, the present application provides a repair cream containing the above repair composition, which adopts the following technical scheme:
a repair cream containing the repair composition comprises the following components in percentage by mass:
7-12% of glycerol;
3-6% of propylene glycol;
2-5% of mineral oil;
poly-gamma-sodium glutamate 0.1-0.5%;
0.2 to 0.8 percent of sodium acrylate/sodium acryloyldimethyl taurate copolymer;
0.1 to 0.5 percent of isohexadecane;
polysorbate-800.05-0.1%;
sorbitan oleate 0.01-0.05%;
0.3 to 0.8 percent of acryloyl dimethyl ammonium taurate/VP copolymer;
carbomer 0.1-0.4%;
0.1 to 0.3 percent of triethanolamine;
0.2 to 0.3 percent of antioxidant;
10-15% of a repair composition;
the balance being solvent.
By adopting the substances with the specific proportion and the repairing composition to be compounded in a synergistic manner, the repairing composition is favorably promoted to be absorbed by the skin better, and the components are favorably and synergistically play a role in moisturizing better, so that the deep moisturizing effect of the skin is better, the skin activity is better, and meanwhile, the skin repairing time is favorably shortened better.
Preferably, the antioxidant comprises one or more of phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate and methylparaben.
Preferably, the antioxidant is prepared by compounding phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate and methylparaben according to the mass ratio of 1:12:0.1-0.2: 15.
By adopting the compounding of substances in a specific proportion as the antioxidant, the storage life of the product is favorably prolonged, and meanwhile, the skin is not easy to be stimulated, so that the product is milder, and the secondary damage to the skin is not easy to occur.
In a third aspect, the present application provides a repairing water containing the above repairing composition, which adopts the following technical scheme:
the repairing water containing the repairing composition comprises the following components in percentage by mass: 3-7% of 1, 3-propylene glycol;
0.1 to 0.25 percent of phenoxyethanol;
0.05 to 0.2 percent of 1, 2-hexanediol;
0.05 to 0.1 percent of chlorophenyl glycoside ether;
0.2-0.5% of allantoin;
0.05 to 0.2 percent of methyl hydroxybenzoate;
10-15% of a repair composition;
the balance being solvent.
By adopting the substances with the specific proportion and the repairing composition to be compounded in a synergistic manner, the repairing composition is favorably promoted to be absorbed by the skin better, and the components are favorably and synergistically play a role in moisturizing better, so that the deep moisturizing effect of the skin is better, the skin activity is better, and meanwhile, the skin repairing time is favorably shortened better.
In summary, the present application has the following beneficial effects:
1. the multiple substances are compounded in a specific ratio, so that the deep water replenishing of the skin is facilitated, the skin is not easy to have the condition of dryness and pruritus, the skin vitality is facilitated to be improved, and the fragile state of the skin is improved; meanwhile, the skin barrier can be better and faster repaired, the regeneration of skin cells can be promoted, the repair and regeneration speed of the skin can be faster, the complete repair time of the skin can be better shortened, and the probability of skin infection can be greatly reduced.
2. By adopting the compounding of substances in a specific proportion as the preservative, the preservative effect of the composition is favorably improved, and simultaneously the influence on the mildness of the composition is not easily caused, so that the composition is not easily influenced on skin to cause secondary damage.
3. The substances in specific proportions and the repairing composition are compounded in a synergistic manner to form the repairing cream or repairing water, so that the skin can be better promoted to absorb the repairing composition, the components can be better synergistic to play a water supplementing effect, the deep water supplementing effect of the skin is better, the skin activity is better, and meanwhile, the skin repairing time can be better shortened.
Detailed Description
The present application will be described in further detail with reference to examples.
In the following examples, comparative examples, experimental examples, blank comparative examples and comparative examples, the materials used were commercially available. Specifically, the feverfew extract, the cornflower extract, the French wintersweet extract and the gentiana sanhuanensis extract are all obtained from Guangzhou Chuanjian chemical technology Co., Ltd; the flos Sophorae Immaturus extract, Chlorella extract, and semen Lini extract are all obtained from Guangzhou Galen biotechnology limited; quinoa seed extract, dendrobium nobile extract and kelp extract were obtained from the plant extraction biotechnology limited company of fei xi county; yeast fermentation lysate filtrate was purchased from Biotech limited of Kingchi, Jilin province. The above extracts are all obtained by alcohol extraction.
Poly-gamma-sodium glutamate was purchased from Bo Zhi more elaborate chemical Co., Ltd, Guangzhou; sodium acrylate/sodium acryloyldimethyl taurate copolymer purchased from SEPPIC s.a.; acryloyldimethyl ammonium taurate/VP copolymers are available from Claien chemical technology (Shanghai) Inc.
Example 1
The embodiment of the application discloses a repairing composition, which consists of the following components in parts by mass:
0.03kg of feverfew extract; 0.003kg of cornflower extract; 0.02kg of French wintersweet extract; 0.03kg of Gentiana triflora extract; 0.03kg of sophora flower bud extract; 0.05kg of chlorella extract; 0.05kg of linseed extract; 0.01kg of quinoa seed extract; 0.1kg of dendrobium nobile lindl extract; 0.01kg of giant kelp extract; yeast fermentation lysate filtrate 4 kg; 5kg of solvent.
In this example, the solvent is water.
The embodiment of the application also discloses a preparation method of the repairing composition, which comprises the following steps: accurately weighing the components according to the mass at normal temperature, mixing the components, and stirring at the rotating speed of 1000r/min until the components are completely dissolved to obtain the repairing composition.
Example 2
The difference from example 1 is that:
the addition amount of each component of the repairing composition is different, and specifically comprises the following components:
0.06kg of feverfew extract; 0.008kg of cornflower extract; 0.07kg of French wintersweet extract; 0.08kg of gentiana trifoliata extract; 0.08kg of sophora flower bud extract; 0.1kg of chlorella extract; 0.1kg of linseed extract; 0.05kg of quinoa seed extract; 0.3kg of dendrobium nobile lindl extract; 0.05kg of giant kelp extract; yeast fermentation lysate filtrate 7 kg; 8kg of solvent.
Example 3
The difference from example 1 is that:
the addition amount of each component of the repairing composition is different, and specifically comprises the following components:
0.05kg of feverfew extract; 0.004kg of cornflower extract; 0.06kg of French wintersweet extract; 0.06kg of gentiana trifoliata extract; 0.06kg of sophora flower bud extract; 0.09kg of chlorella extract; 0.09kg of linseed extract; 0.02kg of quinoa seed extract; 0.2kg of dendrobium nobile lindl extract; 0.02kg of giant kelp extract; yeast fermentation lysate filtrate 5 kg; 6kg of solvent.
Example 4
The difference from example 3 is that: the remedial composition also included 0.5kg of a tetrahydro-methyl-pyrimidine-carboxylic acid.
Example 5
The difference from example 3 is that: the remedial composition also includes 1.5kg of a tetrahydro-methyl-pyrimidine-carboxylic acid.
Example 6
The difference from example 3 is that: the remedial composition also included 1kg of tetrahydro-methyl-pyrimidine carboxylic acid and 0.01kg of preservative.
Wherein the preservative is prepared by compounding p-hydroxyacetophenone, chlorphenesin and methylparaben in a mass ratio of 2:1: 1.
The solvent is prepared by compounding water, 1, 2-hexanediol, butanediol and glycerol according to the mass ratio of 534:1:86: 12.
Example 7
The differences from example 6 are: the addition amount of the preservative is 0.03kg, and the preservative is prepared by compounding p-hydroxyacetophenone, chlorophenyl glycoside ether and methyl hydroxybenzoate according to the mass ratio of 2.5:1: 1.
Comparative example 1
The difference from example 3 is that: equal amounts of feverfew extract were substituted for cornflower extract, french wintersweet extract, and gentiana trivialis extract.
Comparative example 2
The difference from example 3 is that: equal amount of flos Sophorae bud extract is used to replace Chlorella extract and semen Lini extract.
Comparative example 3
The difference from example 3 is that: equal amount of Kunuo A seed extract is used to replace herba Dendrobii extract and Macrocystis extract.
Comparative example 4
The difference from example 3 is that: equal amount of filtrate of fermentation product of tectorial membrane yeast is used to replace filtrate of lysate of yeast.
Experimental example 1
The application experimental example discloses a repair cream containing a repair composition, which consists of the following components:
7kg of glycerol; 3kg of propylene glycol; 2kg of mineral oil; 0.1kg of poly-gamma-sodium glutamate; 0.2kg of sodium acrylate/sodium acryloyldimethyl taurate copolymer; 0.1kg of isohexadecane; 800.05 kg of polysorbate; 0.01kg of sorbitan oleate; 0.3kg of an acryloyl dimethyl ammonium taurate/VP copolymer; 0.1kg of carbomer; 0.1kg of triethanolamine; 0.2kg of antioxidant; 10kg of the repairing composition; 76.84kg of solvent.
In the experimental example, the antioxidant is prepared by compounding phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate and methylparaben according to the mass ratio of 1:12:0.1: 15; the repair composition was the repair composition prepared in example 1; the solvent is water.
The application experimental example also discloses a preparation method of the repair cream containing the repair composition, which comprises the following steps:
step 1, cleaning production equipment and production tools, and sterilizing.
And 2, accurately weighing the substances according to the mass, adding water, glycerol, propylene glycol, acryloyl dimethyl ammonium taurate/VP copolymer, carbomer and methyl hydroxybenzoate into an emulsifying pot, homogenizing for 15min, heating to 85 ℃, and keeping the temperature for 20 min.
And 3, reducing the temperature under natural conditions, adding mineral oil, sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-80 and sorbitan oleate when the temperature is reduced to 75 ℃, and homogenizing for 4min under vacuum.
And 4, when the temperature is continuously reduced to 40 ℃, adding poly gamma-sodium glutamate, phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate, triethanolamine and the repairing composition, stirring and mixing uniformly at the rotating speed of 1000r/min, standing for 24h, and discharging to obtain the repairing cream containing the repairing composition.
Experimental example 2
The differences from the experimental example 1 are: the addition amount of each component is different, and the specific addition amount is as follows:
12kg of glycerol; 6kg of propylene glycol; 5kg of mineral oil; 0.5kg of poly-gamma-sodium glutamate; 0.8kg of sodium acrylate/sodium acryloyldimethyl taurate copolymer; 0.5kg of isohexadecane; 800.1 kg of polysorbate; 0.05kg of sorbitan oleate; 0.8kg of an acryloyl dimethyl ammonium taurate/VP copolymer; carbomer 0.4 kg; 0.3kg of triethanolamine; 0.3kg of antioxidant; 15kg of the repairing composition; 58.25kg of solvent.
In the experimental example, the antioxidant is compounded by phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate and methylparaben in a mass ratio of 1:12:0.2: 15.
Experimental example 3
The difference from experimental example 1 is that: the repair composition was the one prepared in example 2.
Experimental example 4
The differences from the experimental example 1 are: the repair composition was the one prepared in example 3.
Experimental example 5
The difference from experimental example 1 is that: the servicing composition was the servicing composition prepared in example 4.
Experimental example 6
The difference from experimental example 1 is that: the servicing composition was the servicing composition prepared in example 5.
Experimental example 7
The difference from experimental example 1 is that: the repair composition was the one prepared in example 6.
Experimental example 8
The difference from experimental example 1 is that: the repair composition was the one prepared in example 7.
Experimental example 9
The application experimental example discloses repair water containing a repair composition, which consists of the following components in parts by mass:
3kg of 1, 3-propylene glycol; 0.1kg of phenoxyethanol; 0.05kg of 1, 2-hexanediol; 0.05kg of chlorophenyl glycoside ether; allantoin 0.2 kg; 0.05kg of methylparaben; 10kg of the repairing composition; 86.55kg of solvent.
In this experimental example, the repairing composition was the repairing composition prepared in example 1; the solvent is water.
The application experimental example also discloses a preparation method of the repair water, which comprises the following steps:
step 1, cleaning production equipment and production tools, and sterilizing.
And 2, accurately weighing the substances according to the mass, adding water, 1, 3-propylene glycol, allantoin and methyl hydroxybenzoate into a stirring kettle, stirring and mixing uniformly at the rotating speed of 1000r/min, heating to 85 ℃, and preserving heat for 20 min.
And 3, reducing the temperature under natural conditions, adding phenoxyethanol, 1, 2-hexanediol, chlorphenesin and the repairing composition when the temperature is reduced to 40 ℃, uniformly stirring and mixing at the rotating speed of 1000r/min, standing for 24h, and discharging to obtain the repairing water containing the repairing composition.
Experimental example 10
The difference from experimental example 9 is that: the addition amount of each component is different, and the specific addition amount is as follows:
7kg of 1, 3-propylene glycol; 0.25kg of phenoxyethanol; 0.2kg of 1, 2-hexanediol; 0.1kg of chlorophenyl glycoside ether; 0.5kg of allantoin; 0.2kg of methylparaben; 15kg of the repairing composition; 76.75kg of solvent.
Blank comparative example
The difference from experimental example 1 is that: the repair composition was replaced with an equal amount of water.
Comparative Experimental example 1
The difference from experimental example 1 is that: the repairing composition was the repairing composition prepared in comparative example 1.
Comparative experiment example 2
The difference from experimental example 1 is that: the repairing composition was the repairing composition prepared in comparative example 2.
Comparative experiment example 3
The difference from experimental example 1 is that: the repairing composition was the repairing composition prepared in comparative example 3.
Comparative experiment example 4
The differences from the experimental example 1 are: the repairing composition was the repairing composition prepared in comparative example 4.
Experiment 1
150 female volunteers with similar skin qualities and subjected to fruit acid skin changing are randomly selected, the age of the volunteers is 25-40 years, the female volunteers are randomly divided into 15 groups of 10 persons, and each group of volunteers starts to respectively use the repair cream or repair water prepared by the experimental example, the blank comparative experimental example and the comparative experimental example after the fruit acid skin changing is finished, the repair cream or repair water is used 2 times every day, and is used once in the morning and evening, 2g of repair water is used each time, the repair cream or repair water is uniformly smeared on facial skin, the repair water is used until the skin recovers the original state, and the use is stopped when the problems of tight skin, pain skin and red swelling do not occur any more. And recording the days for which the skin of each group of volunteers is restored to the original state and the skin problem is not easy to occur any more, and calculating the average value of the repairing days for the skin of the same group of volunteers to be restored to the original state. In addition, the number of skin itching conditions during the repair was recorded for each group of volunteers.
Experiment 2
Before the first morning of the volunteers used the repair cream or water, the skin moisture content of the volunteers was measured using a skin moisture meter CM825, and the average of the measurement results of the same group of volunteers was calculated and recorded. After the first morning of the volunteers used the repair cream or repair water, the skin moisture content of the volunteers was re-measured at 0.5h, 2h, 5h and 8h after use by a skin moisture meter CM825, and the average value of the measurement results of the same group of volunteers was calculated and recorded.
The data obtained from the above experiments are shown in tables 1 and 2.
TABLE 1
Days (heaven) for restoring skin to original shape The number of people with skin pruritus
Experimental example 1 3.5 0
Experimental example 2 3.3 0
Experimental example 3 3.1 0
Experimental example 4 3.0 0
Experimental example 5 2.8 0
Experimental example 6 2.7 0
Experimental example 7 2.5 0
Experimental example 8 2.4 0
Experimental example 9 3.4 0
Experimental example 10 3.3 0
Blank comparative example 9.4 10
Comparative Experimental example 1 8.1 10
Comparative experiment example 2 7.5 10
Comparative experiment example 3 8.8 10
Comparative experiment example 4 8.5 10
TABLE 2
Figure BDA0003738352160000151
Figure BDA0003738352160000161
According to the comparison of the data of the experimental example 1 and the blank comparative experimental examples and the comparative experimental examples 1-4 in the tables 1 and 2, only by adopting the synergistic combination of the feverfew extract, the cornflower extract, the french chrysanthemum extract, the gentiana trilobata extract, the sophora bud extract, the chlorella extract, the linseed extract, the quinoa seed extract, the dendrobium nobile extract and the kelp extract with the yeast fermentation lysate filtrate, the skin can be better supplemented with deep water, so that the skin is less prone to dry and itching, meanwhile, the skin barrier can be better reestablished, the skin is less prone to secondary infection, and the skin repair speed is higher. The lack of any substance can easily have great influence on the repairing effect.
According to the comparison of the data of the experimental example 1 and the experimental examples 5-6 in the tables 1 and 2, the addition of the tetrahydro-methyl pyrimidine carboxylic acid is beneficial to better deeply moisturizing the skin, and meanwhile, the moisturizing effect is more durable and long-lasting, so that the repairing effect of the composition is better and faster.
According to the comparison of the data of the experimental example 1 and the experimental examples 7-8 in the tables 1 and 2, the preservative formed by compounding the hydroxyacetophenone, the chlorophenyl glycoside ether and the methylparaben in a specific ratio is not easy to influence the mildness of the composition, so that the repairing effect of the composition is not easy to influence.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims (10)

1. A remedial composition characterized by: the paint comprises the following components in parts by mass:
0.03-0.06 part of feverfew extract;
0.003 to 0.008 part of cornflower extract;
0.02-0.07 part of French helichrysum extract;
0.03-0.08 part of gentiana trifoliata extract;
0.03-0.08 part of sophora flower bud extract;
0.05-0.1 part of chlorella extract;
0.05-0.1 part of linseed extract;
0.01-0.05 part of quinoa seed extract;
0.1-0.3 parts of dendrobium nobile lindl extract;
0.01-0.05 part of giant kelp extract;
4-7 parts of yeast fermentation lysate filtrate;
5-8 parts of a solvent.
2. A remedial composition according to claim 1 characterised in that: the repairing composition also comprises the following components in parts by mass:
0.5-1.5 parts of tetrahydromethyl pyrimidine carboxylic acid.
3. A remedial composition according to claim 1 characterised in that: the repairing composition also comprises the following components in parts by mass:
0.01-0.03 part of preservative.
4. A remedial composition according to claim 3 characterised in that: the preservative comprises one or more of p-hydroxyacetophenone, chlorphenesin and methylparaben.
5. A remedial composition according to claim 4 characterised in that: the preservative is prepared by compounding p-hydroxyacetophenone, chlorphenesin and methyl hydroxybenzoate in a mass ratio of 2-2.5:1: 1.
6. A remedial composition according to any of claims 1 to 5 characterised in that: the solvent comprises one or more of water, 1, 2-hexanediol, butanediol and glycerol.
7. A repair cream comprising the repair composition according to any one of claims 1 to 6, characterized in that: the paint comprises the following components in percentage by mass:
7-12% of glycerol;
3-6% of propylene glycol;
2-5% of mineral oil;
poly-gamma-sodium glutamate 0.1-0.5%;
0.2 to 0.8 percent of sodium acrylate/sodium acryloyldimethyl taurate copolymer;
0.1 to 0.5 percent of isohexadecane;
polysorbate-800.05-0.1%;
sorbitan oleate 0.01-0.05%;
0.3 to 0.8 percent of acryloyl dimethyl ammonium taurate/VP copolymer;
carbomer 0.1-0.4%;
0.1 to 0.3 percent of triethanolamine;
0.2 to 0.3 percent of antioxidant;
10-15% of a repair composition;
the balance being solvent.
8. A repair cream containing the repair composition according to claim 7, characterized in that: the antioxidant comprises one or more of phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl alcohol butyl carbamate and methylparaben.
9. A repair cream containing a repair composition according to claim 8, characterized in that: the antioxidant is prepared by compounding phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea, iodopropynyl alcohol butyl carbamate and methylparaben according to the mass ratio of 1:12:0.1-0.2: 15.
10. A remedial water comprising a remedial composition as claimed in any of claims 1 to 6, wherein: the paint comprises the following components in percentage by mass:
3-7% of 1, 3-propylene glycol;
0.1 to 0.25 percent of phenoxyethanol;
0.05 to 0.2 percent of 1, 2-hexanediol;
0.05 to 0.1 percent of chlorophenyl glycoside ether;
0.2-0.5% of allantoin;
0.05 to 0.2 percent of methyl hydroxybenzoate;
10-15% of a repair composition;
the balance being solvent.
CN202210803715.5A 2022-07-09 2022-07-09 Repairing composition, and repairing cream and repairing water containing same Pending CN114983906A (en)

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