CN107412052B - Acne-removing repairing composition and preparation method and application thereof - Google Patents
Acne-removing repairing composition and preparation method and application thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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Abstract
The invention discloses an acne-removing repairing composition which comprises the following components in percentage by weight: 1-12% of picrorhiza rhizome extract; 10-20% of scutellaria baicalensis extract; flos Lonicerae extract 10-20%; 10-20% of salvia miltiorrhiza extract; 10-20% of sophora flavescens extract; 10-20% of linear aspalaxyl extract; 10-20% of white willow bark extract; 10-20% of guava fruit extract; 110-20% of biological sugar gum; the sum of the weight percentages of the components is 100 percent. The acne-removing repairing composition has the advantages of broad-spectrum antibiosis, inflammation diminishing, detoxification, inhibition of the growth of acnes, and promotion of the growth and repair of cells. The invention also provides a preparation method of the acne-removing repairing composition, which has the advantages of few steps, simple flow and safe operation. The invention also provides the essence and the preparation method thereof, the acne removing effect is good, the water and the moisture are preserved, and the repairing capability is strong; the preparation steps are few, the flow is simple, and the operation is safe.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an acne-removing repairing composition and a preparation method and application thereof.
Background
Acne is usually whelk, usually seen in young people, more men than women, and better occurs in the fat-rich areas of cheek, forehead, chin, nasal and buccal sulcus, and then chest, back and shoulder. At the beginning, there are two kinds of acne, white head and black head, which contain cutin and sebum. Acne is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous glands. In adolescence, hormones in the body stimulate hair growth and promote sebaceous glands to secrete more oil, so that a plurality of substances are accumulated in the hair and the sebaceous glands, oil and bacteria are attached, and skin redness and swelling are caused. On the other hand, people who love beauty have the beauty, but many young friends bring different troubles to life and work due to acne on the face. For this reason, various acne-removing products are available on the market.
However, the existing acne-removing products have the following defects: some products have unsatisfactory acne-removing effect; some products have good acne removing effect, but have poor repairing effect, and are easy to leave acne marks and acne pits.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide an acne-removing repair composition which has broad antibacterial spectrum, is capable of diminishing inflammation, detoxifying, dredging and astringing pores, removing skin endotoxin, and promoting cell growth and repair, so that the growth of acnes is inhibited, and the skin is recovered to a healthy state.
The invention also aims to provide a preparation method of the acne-removing repairing composition, which has the advantages of few steps, simple process and safe operation.
The essence provided by the invention has the advantages of good acne removing effect, water retention and moisture retention and strong repairing capability.
The invention aims to provide a preparation method of the essence, which has the advantages of few steps, simple flow and safe operation.
One of the purposes of the invention is realized by adopting the following technical scheme:
the acne-removing repair composition comprises the following components in percentage by weight:
1-12% of picrorhiza rhizome extract; 10-20% of scutellaria baicalensis extract; flos Lonicerae extract 10-20%;
10-20% of salvia miltiorrhiza extract; 10-20% of sophora flavescens extract; 10-20% of linear aspalaxyl extract;
10-20% of white willow bark extract; 10-20% of guava fruit extract; 110-20% of biological sugar gum;
the sum of the weight percentages of the components is 100 percent.
Further, the paint comprises the following components in percentage by weight:
rhizoma picrorhizae extract 3%; 12% of scutellaria baicalensis extract; flos Lonicerae extract 12%;
12% of salvia miltiorrhiza extract; 12% of sophora flavescens extract; 11% of linear aspalaxyl extract;
white willow bark extract 10%; 18% of guava fruit extract; 110 percent of biological sugar gum.
The second purpose of the invention is realized by adopting the following technical scheme:
the preparation method of the acne-removing and repairing composition comprises the following steps: adding picrorhiza rhizome extract, scutellaria baicalensis extract, lonicera confusa extract, salvia miltiorrhiza extract, sophora flavescens extract, linear aspalata extract, white willow bark extract, guava fruit extract and biological carbohydrate gum-1 into a vacuum stirring pot according to the formula ratio, setting the stirring speed to be 20-25r/min, uniformly stirring, and degassing in vacuum for 20min to obtain the acne-removing repairing composition.
The third purpose of the invention is realized by adopting the following technical scheme:
an essence containing an acne-removing repair composition comprises the following components in percentage by weight:
the sum of the weight percentages of the components is 100 percent.
Further, the moisturizer comprises glycerin, butanediol, trehalose and ethylhexyl glycerin, wherein the glycerin, the butanediol, the trehalose and the ethylhexyl glycerin are respectively as follows in percentage by weight in the essence: 1-5% of glycerol; 1-5% of butanediol; trehalose 0.5-3%; 0.5-2% of ethylhexyl glycerol; the thickening agent is carbomer; the neutralizing agent is triethanolamine; the preservative is phenoxyethanol; the solvent is water.
Further, the paint comprises the following components in percentage by weight:
the sum of the weight percentages of the components is 100 percent.
Further, the paint comprises the following components in percentage by weight:
the sum of the weight percentages of the components is 100 percent.
Further, the paint comprises the following components in percentage by weight:
the sum of the weight percentages of the components is 100 percent.
The fourth purpose of the invention is realized by adopting the following technical scheme:
a method for preparing essence comprises the following steps:
a sterilization step: adding the solvent with the formula ratio into a vacuum stirring pot, heating for sterilization, and then cooling;
a primary adding step: dividing the humectant into two parts, namely a first humectant and a second humectant; adding a first humectant under stirring to obtain a first mixture;
a secondary addition step: adding the thickening agent with the formula amount, stirring and homogenizing to obtain a second mixture;
a vacuum degassing step: vacuum degassing to obtain a third mixture;
and (3) adding for three times: adding a neutralizing agent, a preservative, a picrorhiza rhizome extract, a scutellaria baicalensis extract, a lonicera confusa extract, a salvia miltiorrhiza extract, a sophora flavescens extract, a linear aspalata extract, a white willow bark extract, a guava fruit extract, biogel-1 and a second humectant in formula amounts under stirring, and uniformly stirring to obtain the essence.
Further, in the sterilization step, the solvent with the formula amount is added into a vacuum stirring pot, heated to 85-90 ℃, sterilized for 30min, and then cooled to 30-35 ℃; in the one-time adding step, the humectant is divided into two parts which are respectively marked as a first humectant and a second humectant; maintaining the stirring speed at 55-60r/min, adding a first humectant, and stirring for 20-25min to obtain a first mixture; in the secondary adding step, adding the thickening agent with the formula amount, setting the stirring speed to be 30-35r/min, and homogenizing for 3-5min to obtain a second mixture; in the vacuum degassing step, vacuum degassing is carried out for 20-25min to obtain a third mixture; in the third adding step, adding a neutralizing agent, a preservative, a picrorhiza extract, a scutellaria baicalensis extract, a lonicera confusa extract, a salvia miltiorrhiza extract, a sophora flavescens extract, a linear aspalata extract, a white willow bark extract, a guava fruit extract, biological carbohydrate gum-1 and a second humectant in a formula amount under the condition of stirring speed of 20-25r/min, and uniformly stirring to obtain the essence.
Compared with the prior art, the invention has the beneficial effects that:
(1) the acne-removing repairing composition provided by the invention comprises 9 components of picrorhiza kurroa (picrorhiza scrophulariiflora) extract, SCUTELLARIA BAICALENSIS (scutellalaria BAICALENSIS) extract, lonicera confusa (lonicera confusa) extract, SALVIA MILTIORRHIZA (salviae MILTIORRHIZA mirtoria) extract, alabasta filiformis (aspalathus linearis) extract, SOPHORA FLAVESCENS (SOPHORA FLAVESCENS) extract, SALIX ALBA (SALIX ALBA) bark extract, guava (PSIDIUM GUAJAVA) fruit extract and biogum-1, wherein the 9 components are properly combined and synergistically play roles of removing acne, inhibiting bacteria and repairing skin:
the picrorhiza kurroa extract has the effects of clearing heat, eliminating dampness, relieving internal heat, detoxifying and treating eczema externally, the scutellaria baicalensis extract has the effects of resisting pathogenic microorganisms, inflammation, allergy and oxidation, the lonicera confusa extract has the effects of broad-spectrum antibiosis, anti-inflammation and detoxifying, the salvia miltiorrhiza extract can inhibit ester oxidation reaction, acne, pimple and color spot caused by poor blood circulation and regulate water and oil, the linear aspalata extract can resist inflammation and resist viruses, the sophora flavescens extract can clear heat, eliminate dampness, kill parasites, relieve itching, dredge and astringe pores, remove endotoxin impurities in skin, promote the growth and repair of damaged skin cells, recover the activity of subcutaneous capillary rain blood vessel cells, the salix alba bark extract can mildly remove dead skin cells on the surface, condition the physiological activity of the skin cuticle, make the skin smooth and fine, make the skin color uniform and glossy, the psidium guava fruit extract has the obvious inhibition effect on 5 α reductase, and the biological carbohydrate gum-1 can.
The acne-removing repairing composition has the advantages of clear effect, various action ways, safety and no adverse reaction, promotes the skin to recover the healthy state, and thoroughly makes up the obvious defect of single function of a commercially available product.
(2) The essence provided by the invention has the advantages of good acne removing effect, water retention and moisture retention and strong repairing capability.
(3) The preparation method of the acne-removing repair composition and the essence provided by the invention has the advantages of few steps, simple flow and safe operation.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
The acne-removing repair composition comprises the following components in percentage by weight:
1-12% of picrorhiza rhizome extract; 10-20% of scutellaria baicalensis extract; flos Lonicerae extract 10-20%;
10-20% of salvia miltiorrhiza extract; 10-20% of sophora flavescens extract; 10-20% of linear aspalaxyl extract;
10-20% of white willow bark extract; 10-20% of guava fruit extract; 110-20% of biological sugar gum;
the sum of the weight percentages of the components is 100 percent.
The preparation method of the acne-removing and repairing composition comprises the following steps: adding picrorhiza rhizome extract, scutellaria baicalensis extract, lonicera confusa extract, salvia miltiorrhiza extract, sophora flavescens extract, linear aspalata extract, white willow bark extract, guava fruit extract and biological carbohydrate gum-1 into a vacuum stirring pot, setting the stirring speed to be 20-25r/min, uniformly stirring, and degassing in vacuum for 20min to obtain the acne-removing repairing composition.
An essence containing an acne-removing repair composition comprises the following components in percentage by weight:
the sum of the weight percentages of the components is 100 percent.
As a further embodiment, the moisturizer comprises 1-5% of glycerin, 1-5% of butanediol, 0.5-3% of trehalose and 0.5-2% of ethylhexyl glycerin, wherein the weight percentages of glycerin, butanediol, trehalose and ethylhexyl glycerin refer to the weight percentage in the essence; the thickening agent is carbomer; the neutralizer is triethanolamine; the preservative is phenoxyethanol; the solvent is water.
The essence provided by the embodiment of the invention contains 9 components of rhizoma picrorhizae extract, scutellaria baicalensis extract, lonicera confusa extract, salvia miltiorrhiza extract, sophora flavescens extract, linear aspalata extract, white willow bark extract, guava fruit extract and biological carbohydrate gum-1, wherein the 9 components are properly compatible and synergistically play the functions of inhibiting bacteria, removing acnes and repairing skin:
the picrorhiza kurroa extract has the effects of clearing heat, eliminating dampness, relieving internal heat, detoxifying and treating eczema externally, the scutellaria baicalensis extract has the effects of resisting pathogenic microorganisms, inflammation, allergy and oxidation, the lonicera confusa extract has the effects of broad-spectrum antibiosis, anti-inflammation and detoxifying, the salvia miltiorrhiza extract can inhibit ester oxidation reaction, acne, pimple and color spot caused by poor blood circulation and regulate water and oil, the linear aspalata extract can resist inflammation and resist viruses, the sophora flavescens extract can clear heat, eliminate dampness, kill parasites, relieve itching, dredge and astringe pores, remove endotoxin impurities in skin, promote the growth and repair of damaged skin cells, recover the activity of subcutaneous capillary rain blood vessel cells, the salix alba bark extract can mildly remove dead skin cells on the surface, condition the physiological activity of the skin cuticle, make the skin smooth and fine, make the skin color uniform and glossy, the psidium guava fruit extract has the obvious inhibition effect on 5 α reductase, and the biological carbohydrate gum-1 can.
The essence has the advantages of clear effect, various and safe action routes, no adverse reaction, good acne removing effect, water retention, moisture retention, strong repairing capability, promotion of skin to recover a healthy state, and complete compensation of the obvious defect of single function of a commercially available product. Furthermore, the acne-removing repair composition has not been reported to date or used for acne-removing and skin repair.
A method for preparing essence comprises the following steps:
a sterilization step: adding the solvent with the formula ratio into a vacuum stirring pot, heating for sterilization, and then cooling;
a primary adding step: dividing the humectant into two parts, namely a first humectant and a second humectant; adding a first humectant under stirring to obtain a first mixture;
a secondary addition step: adding the thickening agent with the formula amount, stirring and homogenizing to obtain a second mixture;
a vacuum degassing step: vacuum degassing to obtain a third mixture;
and (3) adding for three times: adding a neutralizing agent, a preservative, a picrorhiza rhizome extract, a scutellaria baicalensis extract, a lonicera confusa extract, a salvia miltiorrhiza extract, a sophora flavescens extract, a linear aspalata extract, a white willow bark extract, a guava fruit extract, biogel-1 and a second humectant in formula amount under stirring, and uniformly stirring to obtain the essence.
The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.
Examples 1 to 3
An essence comprises picrorhiza rhizome extract, scutellaria baicalensis extract, lonicera confusa extract, salvia miltiorrhiza extract, sophora flavescens extract, linear aspalata extract, willow bark extract, guava fruit extract, biological carbohydrate gum-1, glycerol, butylene glycol, trehalose, ethylhexyl glycerol, carbomer, triethanolamine, phenoxyethanol and water, and the components are shown in the following table 1.
Table 1 formula table of essences of examples 1 to 3 and comparative example 1
The preparation method of the essence comprises the following steps:
a sterilization step: adding water with the formula ratio into a vacuum stirring pot, heating to 88 ℃, sterilizing for 30min, and then cooling to 32 ℃;
a primary adding step: maintaining the stirring speed at 58r/min, sequentially adding glycerol and butanediol, and stirring for 22min to obtain a first mixture;
a secondary addition step: adding carbomer in a formula amount, setting the stirring speed to be 33r/min, and homogenizing for 3-5min to obtain a second mixture; in the vacuum degassing step, vacuum degassing is performed for 22min to obtain a third mixture;
and (3) adding for three times: adding formula amounts of triethanolamine, phenoxyethanol, picrorhiza rhizome extract, scutellaria baicalensis extract, lonicera confusa extract, salvia miltiorrhiza extract, sophora flavescens extract, linear aspalata extract, white willow bark extract, guava fruit extract, biological carbohydrate gum-1, trehalose and ethylhexylglycerin under the condition of stirring speed of 22r/min, and uniformly stirring to obtain the essence.
Discharging, standing, checking, filling, packaging and spraying codes; and warehousing after the inspection is qualified.
Comparative example 1
Comparative example 1 differs from example 1 in that: formulation differences (see table 1 for details), not containing the acne-removing repair composition of examples 1-3;
the rest is the same as in example 1.
Comparative example 2
A certain brand of acne-removing repair essence is sold in the market.
Effect evaluation and Performance detection
1. Bacteriostatic performance test
Test subjects: coli (escherichia coli), p.aeruginosa (pseudomonas aeruginosa), c.albicans (candida albicans), p.acnes (propionibacterium acnes), s.aureus (staphylococcus aureus), s.epidermidis (staphylococcus epidermidis);
the test method comprises the following steps: performing the test for 20min according to the test method for the antibacterial performance of the dissoluble antibacterial product in GB15979-2002 appendix C4;
test samples: the acne-removing repair essence of examples 1 to 3 and comparative examples 1 to 2;
the test results are shown in table 2 below.
TABLE 2 antibacterial Properties test results of the essences of examples 1 to 3 and comparative examples 1 to 2 are recorded in the Table
As can be seen from the data in Table 2, the essences of examples 1-3 all had very good inhibitory effects against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, and the inhibitory effects were much higher than those of comparative example 2. The essence of comparative example 1 hardly exerts any bacteriostatic effect because the acne-removing repair composition of examples 1-3 is not added. The essence of examples 1 to 3 can inhibit bacteria, prevent the pox skin from continuing to be infected with bacteria, and is beneficial to skin recovery.
2. Skin repair efficacy test
By utilizing an EdU cell proliferation detection method, the essences of the examples 1-3 and the comparative examples 1-2 are respectively added into a culture medium, human immortalized epidermal cells (HaCat) are incubated under a certain condition, newly proliferated cells can be accurately detected by detecting EdU permeated into the HaCat during DNA replication with the help of a fluorescence detection tool, the percentage of the cells in the S phase is rapidly counted, and then the cell proliferation condition is analyzed. The results are given in Table 3 below.
Table 3 skin repair efficacy test results of the essences of examples 1 to 3 and comparative examples 1 to 2 are recorded in the table
| Sample (I) | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 |
| The proliferation rate% | 57.85 | 40.10 | 21.22 | 8.35 | 2.11 |
As can be seen from the data in Table 3, the cell proliferation rates using the essences of examples 1-3 were all higher than those of comparative examples 1-2, and particularly, the proliferation rate of example 1 reached 57.85%, which is the best example, indicating that the essences of examples 1-3 can repair skin well and restore skin to a healthy state.
3. Testing of moisturizing performance
Selecting 50 female volunteers of 18-50 ages, dividing into 5 groups of 10 persons, and respectively applying the essence of examples 1-3 and comparative examples 1-2 to the volunteers of each group in indoor environment with 20 deg.C and 50% relative humidityDrawing a forehead of 2cm2The skin moisture change data (average of 10 volunteers in the group) were obtained by integrating the skin moisture change data measured by a Corneometer CM285 skin moisture meter after applying the corresponding essence to the fixed area, and the test results are shown in table 4 below:
table 4 moisturizing performance test results of the essences of examples 1 to 3 and comparative example 2
As can be seen from the data in Table 4, the essence solutions of examples 1 to 3 are excellent in water-replenishing and water-retaining properties, and particularly, the essence solution of example 1 is the most preferable example in which both the water-replenishing rate and the water-retaining rate are maximum values. The essence of examples 1-3 can keep the skin in a moist state, accelerate the repair of the skin and greatly reduce the phenomena of excessive secretion of skin oil and acne.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. The acne-removing repairing composition is characterized by comprising the following components in percentage by weight:
1-12% of picrorhiza rhizome extract; 10-20% of scutellaria baicalensis extract; flos Lonicerae extract 10-20%;
10-20% of salvia miltiorrhiza extract; 10-20% of sophora flavescens extract; 10-20% of linear aspalaxyl extract;
10-20% of white willow bark extract; 10-20% of guava fruit extract; 110-20% of biological sugar gum;
the sum of the weight percentages of the components is 100 percent.
2. The acne treatment repair composition according to claim 1, comprising the following components in percentage by weight:
rhizoma picrorhizae extract 3%; 12% of scutellaria baicalensis extract; flos Lonicerae extract 12%;
12% of salvia miltiorrhiza extract; 12% of sophora flavescens extract; 11% of linear aspalaxyl extract;
white willow bark extract 10%; 18% of guava fruit extract; 110 percent of biological sugar gum.
3. A method for preparing the acne-removing repairing composition according to claim 1 or 2, which is prepared according to the following method: adding picrorhiza rhizome extract, scutellaria baicalensis extract, lonicera confusa extract, salvia miltiorrhiza extract, sophora flavescens extract, linear aspalata extract, white willow bark extract, guava fruit extract and biological carbohydrate gum-1 into a vacuum stirring pot according to the formula ratio, setting the stirring speed to be 20-25r/min, uniformly stirring, and degassing in vacuum for 20min to obtain the acne-removing repairing composition.
4. An essence comprising the acne-removing repair composition according to claim 1, which is characterized by comprising the following components in percentage by weight:
the sum of the weight percentages of the components is 100 percent.
5. The essence of claim 4, wherein the moisturizer comprises glycerin, butylene glycol, trehalose and ethylhexyl glycerin, and the glycerin, butylene glycol, trehalose and ethylhexyl glycerin are respectively in the following weight percentages in the essence: 1-5% of glycerol; 1-5% of butanediol; trehalose 0.5-3%; 0.5-2% of ethylhexyl glycerol;
the thickening agent is carbomer; the neutralizing agent is triethanolamine; the preservative is phenoxyethanol; the solvent is water.
6. The essence of claim 4, comprising the following components in weight percent:
the sum of the weight percentages of the components is 100 percent.
7. The essence of claim 4, comprising the following components in weight percent:
the sum of the weight percentages of the components is 100 percent.
8. The essence of claim 4, comprising the following components in weight percent:
the sum of the weight percentages of the components is 100 percent.
9. The method for preparing the essence of claim 4, which comprises:
a sterilization step: adding the solvent with the formula ratio into a vacuum stirring pot, heating for sterilization, and then cooling;
a primary adding step: dividing the humectant into two parts, namely a first humectant and a second humectant; adding a first humectant under stirring to obtain a first mixture;
a secondary addition step: adding the thickening agent with the formula amount, stirring and homogenizing to obtain a second mixture;
a vacuum degassing step: vacuum degassing to obtain a third mixture;
and (3) adding for three times: adding a neutralizing agent, a preservative, a picrorhiza rhizome extract, a scutellaria baicalensis extract, a lonicera confusa extract, a salvia miltiorrhiza extract, a sophora flavescens extract, a linear aspalata extract, a white willow bark extract, a guava fruit extract, biogel-1 and a second humectant in formula amounts under stirring, and uniformly stirring to obtain the essence.
10. The method for preparing the essence according to claim 9, wherein in the sterilization step, the solvent in the formula amount is added into a vacuum stirring pot, heated to 85-90 ℃, sterilized for 30min, and then cooled to 30-35 ℃;
in the one-time adding step, the humectant is divided into two parts which are respectively marked as a first humectant and a second humectant; maintaining the stirring speed at 55-60r/min, adding a first humectant, and stirring for 20-25min to obtain a first mixture;
in the secondary adding step, adding the thickening agent with the formula amount, setting the stirring speed to be 30-35r/min, and homogenizing for 3-5min to obtain a second mixture;
in the vacuum degassing step, vacuum degassing is carried out for 20-25min to obtain a third mixture;
in the third adding step, adding a neutralizing agent, a preservative, a picrorhiza extract, a scutellaria baicalensis extract, a lonicera confusa extract, a salvia miltiorrhiza extract, a sophora flavescens extract, a linear aspalata extract, a white willow bark extract, a guava fruit extract, biological carbohydrate gum-1 and a second humectant in a formula amount under the condition of stirring speed of 20-25r/min, and uniformly stirring to obtain the essence.
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| CN108175727A (en) * | 2017-12-28 | 2018-06-19 | 广州蜜妆生物科技有限公司 | A kind of anti-acne print Face-protecting mask patch and preparation method thereof |
| CN111821243A (en) * | 2020-09-04 | 2020-10-27 | 广州市轩颜化妆品有限公司 | Acne-removing and oil-controlling facial cleaning bubble with radix sophorae flavescentis for face and preparation method of acne-removing and oil-controlling facial cleaning bubble |
| CN112076133A (en) * | 2020-10-26 | 2020-12-15 | 惠州市百年丽人化妆品有限公司 | Compound plant acne-removing composition and preparation method and application thereof |
| CN112516034A (en) * | 2020-12-21 | 2021-03-19 | 广州旭帆生物科技有限公司 | Plant acne removing agent and preparation method and application thereof |
| CN114432205A (en) * | 2022-03-02 | 2022-05-06 | 爱西美(珠海)生物技术有限公司 | Plant acne removing factor |
| CN115024987A (en) * | 2022-05-31 | 2022-09-09 | 彭氏(惠州)实业发展有限公司 | Three-layer essence with repairing and moisturizing effects and preparation method and application thereof |
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