CN113018233A - Bacteriostatic and itching-relieving plant composition and preparation method and application thereof - Google Patents
Bacteriostatic and itching-relieving plant composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN113018233A CN113018233A CN202110261720.3A CN202110261720A CN113018233A CN 113018233 A CN113018233 A CN 113018233A CN 202110261720 A CN202110261720 A CN 202110261720A CN 113018233 A CN113018233 A CN 113018233A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- bacteriostatic
- itching
- plant composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 97
- 239000000203 mixture Substances 0.000 title claims abstract description 97
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 61
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 131
- 241000196324 Embryophyta Species 0.000 claims abstract description 96
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- 230000007803 itching Effects 0.000 claims abstract description 35
- 230000001139 anti-pruritic effect Effects 0.000 claims abstract description 30
- 239000003908 antipruritic agent Substances 0.000 claims abstract description 29
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 26
- 239000008367 deionised water Substances 0.000 claims abstract description 24
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 24
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 24
- 244000038594 Phyllanthus urinaria Species 0.000 claims abstract description 22
- 244000292697 Polygonum aviculare Species 0.000 claims abstract description 20
- 235000006386 Polygonum aviculare Nutrition 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 240000006688 Telosma cordata Species 0.000 claims abstract description 16
- 235000017352 Telosma cordata Nutrition 0.000 claims abstract description 16
- 239000006260 foam Substances 0.000 claims abstract description 14
- 239000006210 lotion Substances 0.000 claims abstract description 13
- 241000972672 Phellodendron Species 0.000 claims abstract description 11
- 241000246044 Sophora flavescens Species 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- 239000000843 powder Substances 0.000 claims description 28
- 239000000706 filtrate Substances 0.000 claims description 25
- 230000002829 reductive effect Effects 0.000 claims description 20
- 238000000605 extraction Methods 0.000 claims description 19
- 230000000844 anti-bacterial effect Effects 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 18
- 239000002562 thickening agent Substances 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 17
- 238000010257 thawing Methods 0.000 claims description 17
- 239000000341 volatile oil Substances 0.000 claims description 16
- 241000411851 herbal medicine Species 0.000 claims description 15
- 239000003755 preservative agent Substances 0.000 claims description 15
- 230000002335 preservative effect Effects 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 239000003995 emulsifying agent Substances 0.000 claims description 13
- 239000003974 emollient agent Substances 0.000 claims description 12
- 239000003906 humectant Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 238000002386 leaching Methods 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims description 8
- 239000004299 sodium benzoate Substances 0.000 claims description 8
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 claims description 7
- 241000219784 Sophora Species 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 7
- 235000013336 milk Nutrition 0.000 claims description 7
- 239000008267 milk Substances 0.000 claims description 7
- 210000004080 milk Anatomy 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 5
- 240000001548 Camellia japonica Species 0.000 claims description 5
- 229920004933 Terylene® Polymers 0.000 claims description 5
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 5
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 235000018597 common camellia Nutrition 0.000 claims description 5
- 238000009833 condensation Methods 0.000 claims description 5
- 230000005494 condensation Effects 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 229940057910 shea butter Drugs 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 5
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical group [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 4
- 240000007817 Olea europaea Species 0.000 claims description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 229960003237 betaine Drugs 0.000 claims description 4
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 4
- 229940049964 oleate Drugs 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- 241001253169 Asystasia gangetica Species 0.000 claims description 2
- DSGPMWAUIWWQKT-UHFFFAOYSA-N C1(=CC=CC=C1)OC(CC)=O.[Na] Chemical compound C1(=CC=CC=C1)OC(CC)=O.[Na] DSGPMWAUIWWQKT-UHFFFAOYSA-N 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 2
- 229940113120 dipropylene glycol Drugs 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 244000301850 Cupressus sempervirens Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 21
- 239000003814 drug Substances 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 6
- 230000000638 stimulation Effects 0.000 abstract description 5
- 206010013700 Drug hypersensitivity Diseases 0.000 abstract 1
- 201000005311 drug allergy Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 37
- 238000012360 testing method Methods 0.000 description 16
- 239000000686 essence Substances 0.000 description 12
- 241000972673 Phellodendron amurense Species 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 229930003935 flavonoid Natural products 0.000 description 6
- 150000002215 flavonoids Chemical class 0.000 description 6
- 235000017173 flavonoids Nutrition 0.000 description 6
- 206010040914 Skin reaction Diseases 0.000 description 5
- 229930013930 alkaloid Natural products 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 229960001660 histamine phosphate Drugs 0.000 description 5
- 230000035483 skin reaction Effects 0.000 description 5
- 231100000430 skin reaction Toxicity 0.000 description 5
- 241000700199 Cavia porcellus Species 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- ZHIBQGJKHVBLJJ-UHFFFAOYSA-N histamine phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.NCCC1=CNC=N1 ZHIBQGJKHVBLJJ-UHFFFAOYSA-N 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 238000002390 rotary evaporation Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 229940126680 traditional chinese medicines Drugs 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 241000700198 Cavia Species 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- WVTKBKWTSCPRNU-KYJUHHDHSA-N (+)-Tetrandrine Chemical compound C([C@H]1C=2C=C(C(=CC=2CCN1C)OC)O1)C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@@H]2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-KYJUHHDHSA-N 0.000 description 2
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 2
- NGSWKAQJJWESNS-UHFFFAOYSA-N 4-coumaric acid Chemical compound OC(=O)C=CC1=CC=C(O)C=C1 NGSWKAQJJWESNS-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 description 2
- 102100031294 Thymic stromal lymphopoietin Human genes 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000000548 hind-foot Anatomy 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 1
- YLRXAIKMLINXQY-ZDUSSCGKSA-O (S)-magnoflorine Chemical compound C1=C(OC)C(O)=C2C3=C(O)C(OC)=CC=C3C[C@@H]3[N+](C)(C)CCC1=C23 YLRXAIKMLINXQY-ZDUSSCGKSA-O 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- IEMXKEMFCFILAA-UHFFFAOYSA-N 2-docosylphenol Chemical compound CCCCCCCCCCCCCCCCCCCCCCC1=CC=CC=C1O IEMXKEMFCFILAA-UHFFFAOYSA-N 0.000 description 1
- JXRYDOZRPYFBKO-UHFFFAOYSA-N 3,4-dimethoxy-cinnamic acidmethyl ester Natural products COC(=O)C=CC1=CC=C(OC)C(OC)=C1 JXRYDOZRPYFBKO-UHFFFAOYSA-N 0.000 description 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-M 4-Hydroxycinnamate Natural products OC1=CC=C(\C=C\C([O-])=O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-M 0.000 description 1
- DFYRUELUNQRZTB-UHFFFAOYSA-N Acetovanillone Natural products COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241001106067 Atropa Species 0.000 description 1
- 241000167550 Centella Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- 241000437896 Corydalis bungeana Species 0.000 description 1
- 235000007106 Crataegus suborbiculata Nutrition 0.000 description 1
- 241000073432 Crataegus suborbiculata Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102100023688 Eotaxin Human genes 0.000 description 1
- 101710139422 Eotaxin Proteins 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 208000035357 Focal Infection Diseases 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 240000004153 Hibiscus sabdariffa Species 0.000 description 1
- 235000001018 Hibiscus sabdariffa Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 241000334160 Isatis Species 0.000 description 1
- KYEAXNAYHSCLMT-CVVGWEDFSA-N Magnoflorine Natural products C[C@H]1OC=C2[C@@H]3[C@@H]1CN4CCc5c([nH]c6ccccc56)[C@@H]4[C@@H]3OC2=O KYEAXNAYHSCLMT-CVVGWEDFSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 244000137852 Petrea volubilis Species 0.000 description 1
- RBBVPNQTBKHOEQ-KKSFZXQISA-O Phellodendrine Chemical compound C1CC2=CC(OC)=C(O)C=C2[C@H]2[N@+]1(C)CC(C=C(C(=C1)O)OC)=C1C2 RBBVPNQTBKHOEQ-KKSFZXQISA-O 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 244000137773 Viola philippica Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 235000013202 a hawthorn Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 235000020221 chamomile extract Nutrition 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 1
- 229960003677 chloroquine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 208000037805 labour Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 150000005692 lignans Chemical class 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- OCNYGKNIVPVPPX-HWKANZROSA-N methyl caffeate Chemical compound COC(=O)\C=C\C1=CC=C(O)C(O)=C1 OCNYGKNIVPVPPX-HWKANZROSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229940105902 mint extract Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940064064 purslane extract Drugs 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- WVTKBKWTSCPRNU-UHFFFAOYSA-N rac-Tetrandrin Natural products O1C(C(=CC=2CCN3C)OC)=CC=2C3CC(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2CC2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000004347 surface barrier Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a bacteriostatic itching-relieving plant composition and a preparation method and application thereof, wherein the bacteriostatic itching-relieving plant composition comprises the following raw materials in parts by weight: 5-10 parts of phyllanthus urinaria extract, 3-10 parts of perfoliate knotweed extract, 6-15 parts of phellodendron extract, 5-10 parts of sophora flavescens extract, 8-12 parts of Chinese violet extract, 3-6 parts of spreading hedyotis herb and 37-70 parts of deionized water; the invention also discloses a preparation method of the plant composition for inhibiting bacteria and relieving itching and application of the plant composition for inhibiting bacteria and relieving itching in preparing bath foam and body lotion; the bacteriostatic and antipruritic plant composition prepared by the invention has the effects of inhibiting the growth of bacteria and relieving itching and repairing well aiming at pruritus caused by dryness, infection or other stimulation of skin; meanwhile, the plant composition is prepared from natural plant components, and has the advantages of low toxicity and difficulty in generating drug allergy compared with a treatment drug prepared from western medicine components.
Description
Technical Field
The invention belongs to the field of personal care products, and particularly relates to a bacteriostatic itching-relieving plant composition, and a preparation method and application thereof.
Background
In daily life, after people do exercises and labours, pores expand due to fever and sweating, and at the moment, the skin is easily infected by bacteria, and the problems of skin itch and the like occur. According to statistics, about one fifth of the population today suffers from various degrees of skin itching and allergy. From the medical point of view, skin itch mainly refers to the abnormal phenomena of redness, itching, peeling, allergic dermatitis and the like which are caused when skin is stimulated by various pollution sources, such as cosmetics, chemical agents, pollen, food, polluted air and the like which have adverse reactions. The incidence rate of skin diseases in China is as high as 1.23 percent, wherein the most main disease is skin pruritus. The causes of skin itch are complex and are divided into two aspects of internal causes and external causes; wherein, the internal cause package is mainly systemic diseases, such as endocrine diseases, liver and gall diseases, kidney diseases, malignant tumors and the like which can cause skin itch; external factors are related to climate, temperature, mechanical (friction, etc.), chemical stimulation (acid-base, etc.), drugs (belladonna, cimetidine, chloroquine, etc.), mosquito and insect bites. In addition to the above factors, focal infections, drug, food allergies, and parasitic or fungal infections can cause systemic or localized skin itching.
Aiming at common pruritus in daily life, people often adopt a shower mode to remove pollution sources such as dust and the like attached to the surface of skin so as to eliminate pruritus. At the moment, common bath foam and perfumed soap have no obvious effect of relieving itching and removing bacteria, and people go to a pharmacy to buy various creams, etc., which are not convenient for applying on the whole body and have high cost; in addition, the folk-used skin care products for degerming are needed to solve the above-mentioned problems because the efficacy of the folk-used skin care products is difficult to have stable efficacy and usually addresses the symptoms rather than the root causes. At present, hormone medicines are mostly used for inhibiting pruritus and resisting dermatitis clinically, but the toxic and side effects are large, radical treatment is not easy, more and more people turn to research traditional Chinese medicines, and the traditional Chinese medicines in the traditional Chinese medicine consider that the pruritus cutanea is related to heart fire and lung heat, so the traditional Chinese medicines for clearing heat and removing toxicity are common medicines for treating the pruritus cutanea.
Various preparations such as dexamethasone and cortisone mainly comprising chemical drugs are mostly adopted as antipruritic agents on the market, but the chemical preparations have quick curative effect but are often accompanied by side effects. In order to further improve the safety of products, a plurality of daily care products containing traditional Chinese medicine components for skin pruritus are also provided. Chinese patent document with application number 201510834512.2 discloses Pudilan antibacterial itching-relieving shower gel and a preparation method thereof, wherein the main itching-relieving substance is Pudilan which is composed of four traditional Chinese medicines of scutellaria baicalensis, isatis roots, dandelion and corydalis bungeana, and the formula in the shower gel disclosed by the invention contains more emulsifier components, is high in dosage and complex in components and is not suitable for long-term use; chinese patent with application number of 201910520622.X discloses an antibacterial and itching relieving traditional Chinese medicine composition and application thereof, and particularly discloses a traditional Chinese medicine composition at least comprising a centella extract, a purslane extract, a chamomile extract, a witch hazel extract, a honeysuckle extract, a roselle flower extract, a hawthorn extract, a mint extract, an aloe extract and betaine.
Disclosure of Invention
In order to solve the problems, the invention provides a plant composition with good and lasting antibacterial and itching relieving effects and a preparation method thereof, the plant composition adopts liquid nitrogen low-temperature freeze thawing treatment on 6 Chinese herbal medicines, so that more beneficial components are dissolved out, the yield is improved, meanwhile, 3 extracts and 3 extracts are compounded to obtain the plant composition, the plant composition contains a small amount of essential oil components, water-soluble substances in plants, natural components and light fragrance, and meanwhile, the plant composition is used for preparing daily care products such as bath foam, body lotion and the like.
The purpose of the invention is realized by the following technical scheme:
the invention discloses a bacteriostatic and itching-relieving plant composition which comprises the following raw materials in parts by weight: 5-10 parts of phyllanthus urinaria extract, 3-10 parts of perfoliate knotweed extract, 6-15 parts of phellodendron extract, 5-10 parts of sophora flavescens extract, 8-12 parts of philippine violet herb extract, 3-6 parts of spreading hedyotis herb extract and 37-70 parts of deionized water.
The invention also discloses a preparation method of the plant composition for inhibiting bacteria and relieving itching, which comprises the following steps:
(1) pretreatment: cleaning and drying whole phyllanthus urinaria, perfoliate knotweed, phellodendron, radix sophorae flavescentis, Chinese violet and spreading hedyotis herb, crushing and sieving by a 30-mesh sieve, packaging the obtained Chinese herbal medicine powder by 100% terylene cloth, quickly freezing the packaged Chinese herbal medicine powder in liquid nitrogen in a Dewar flask, quickly taking out the packaged Chinese herbal medicine powder after 1-2 min, putting the packaged Chinese herbal medicine powder into a boiling water solution for unfreezing for 10-12 min, and performing freezing-unfreezing cycle for multiple times;
(2) respectively putting the phyllanthus urinaria powder and the oldenlandia diffusa powder which are subjected to low-temperature freeze thawing treatment into containers, adding 5 times of ethanol solution with the mass concentration of 75%, leaching at room temperature, shaking once every 2-3 h, performing suction filtration after 6h, and collecting filtrate; repeatedly leaching for 1 time, combining filtrates, placing in a rotary evaporation evaporator at 60-65 deg.C under 0.90-0.95 atm, concentrating under reduced pressure, and evaporating to remove solvent to obtain Phyllanthus urinaria extract and herba Hedyotidis Diffusae extract;
(3) adding distilled water into the Chinese violet powder subjected to low-temperature freeze thawing treatment according to the solid-to-liquid ratio of 1:20, extracting for 3 times by using a condensation reflux method, setting the temperature of a water bath kettle to be 70-75 ℃, and setting the time for single extraction to be 2-3 h; filtering under reduced pressure after each extraction is finished, combining the two filtrates, transferring the combined filtrates into a rotary evaporator, concentrating the combined filtrates under reduced pressure to one third of the volume of the original solution, adding 3 times of 85% ethanol in the concentrated mixed solution for precipitation for 24-30 h, filtering under reduced pressure, and drying the obtained precipitate in a vacuum freeze dryer to obtain the herba violae extract;
(4) extracting herba Polygoni Perfoliati, cortex Phellodendri and radix Sophorae Flavescentis after low temperature freeze thawing treatment in a steam extraction device until no essential oil appears, and separating essential oil and extract to obtain herba Polygoni Perfoliati extract, cortex Phellodendri extract and radix Sophorae Flavescentis extract respectively;
(5) the perfoliate knotweed herb extract, the phellodendron extract, the sophora flavescens extract, the Chinese violet extract, the spreading hedyotis herb extract and deionized water are mixed according to the weight ratio of the raw materials to obtain the traditional Chinese medicine extract with the functions of inhibiting bacteria and relieving itching.
The invention also discloses an application of the antibacterial itching-relieving plant composition in preparation of daily nursing articles for skin itching, wherein the addition amount of the antibacterial itching-relieving plant composition is 2-10%.
The invention also discloses application of the bacteriostatic itching-relieving plant composition in bath foam, wherein the bath foam containing the bacteriostatic itching-relieving plant composition at least comprises, by weight, 10-20 parts of AES, 10-15 parts of amino acid surfactant, 2-5 parts of the bacteriostatic itching-relieving plant composition, 7-15 parts of glycerol, 0.02-0.5 part of preservative, 0.5-4 parts of thickening agent, 0.001-0.5 part of essence and 40-70 parts of deionized water.
Further, the amino acid surfactant is sodium lauroyl glutamate; the thickening agent is hydroxypropyl methyl cellulose.
Further, the preservative is a compound product of phenoxyethanol and sodium phenylpropionate.
The invention also discloses an application of the plant composition for bacteriostasis and relieving itching in body milk, wherein the body milk containing the plant composition for bacteriostasis and relieving itching at least comprises, by weight, 2-10 parts of an emulsifier, 10-20 parts of an emollient, 5-8 parts of the plant composition for bacteriostasis and relieving itching, 8-11 parts of a humectant, 0.1-0.5 part of a thickener, 0.01-0.1 part of a pH regulator, 0.05-1 part of a preservative, 0.001-0.1 part of an essence and 40-60 parts of deionized water.
Further, the emulsifier is one or more of cetearyl olive oleate, lecithin hydroxyethyl acrylate and cetearyl alcohol; the emollient is one or more of shea butter, polydimethylsiloxane, camellia seed oil and caprylic triglyceride; the humectant is one or more of dipropylene glycol, glycerol, betaine and sodium hyaluronate; the thickening agent is xanthan gum; the pH regulator is EDTA disodium; the preservative is sodium benzoate.
Further, the preparation method of the body lotion containing the bacteriostatic itching-relieving plant composition comprises the following steps:
(1) weighing emulsifier and emollient, adding into oil phase pan, mixing to obtain phase A raw material, and heating to 80-85 deg.C;
(2) adding deionized water, thickener and humectant into water phase pot, mixing to obtain phase B, and heating to 80-85 deg.C.
(3) Sequentially pumping A, B phase raw materials into an emulsifying pot, and homogenizing and stirring at 3000r/min for 15 min; keeping the temperature for 15min, and then cooling, and keeping the vacuum degree at-0.08 MPa;
(4) cooling to 45-50 deg.C, adding antibacterial and antipruritic plant composition, pH regulator, antiseptic, and essence, and mixing to obtain body lotion containing antibacterial and antipruritic plant composition.
Compared with the prior art, the invention has the following beneficial effects:
1. the bacteriostatic itching-relieving plant composition is prepared by compounding three excellent natural product extracts of an underleaf pearl extract, a Chinese violet extract and a spreading hedyotis herb extract, wherein the underleaf pearl extract mainly contains chemical components such as tannins, flavonoids, lignans, organic acids, terpenes, steroids, polyphenols and the like, and phenolic hydroxyl of the underleaf pearl extract can destroy cell membranes of microorganisms, so that proteins in the cells are denatured, and the activities of a respiring enzyme system and an electron transfer enzyme system of the microbial cells can be inhibited, so that the bactericidal and bacteriostatic effects are achieved; the Chinese violet extract mainly contains polysaccharide, water-soluble minerals and the like, wherein the polysaccharide is used as a natural moisturizing factor, can obviously promote the skin moisturizing capability, repair skin surface barriers, reduce the loss of water through the epidermis, keep the skin moist and healthy, enhance the resistance of the skin to external stimulation, reduce the skin sensitivity, solve the problem of pruritus caused by dry skin, and more minerals can activate cells and enhance the osmotic absorption effect of the skin on active ingredients such as polyphenol, alkaloid, polysaccharide and flavonoid in the Chinese herbal medicine composition; the oldenlandia diffusa contains organic acids and flavonoids which have strong bacteriostatic action and have most obvious bactericidal action and bacteriostatic action on staphylococcus aureus, and the staphylococcus aureus is one of bacteria causing pruritus on the surface of skin; in addition, the flavonoids have oxidation resistance, can resist excessive free radicals caused by environmental stimulation, reduce the damage of external factors such as ultraviolet rays and the like to the skin, promote the collagen proliferation and angiogenesis of the dermis of the skin, repair the deep injury of the dermis of the skin and maintain the healthy and young state of the skin; therefore, the phyllanthus urinaria and the oldenlandia diffusa can eliminate or inhibit bacteria on the surface of the skin in the use process, the Chinese violet extract can activate cells on the surface layer of the skin, assist absorption and permeation of functional components of the phyllanthus urinaria and the oldenlandia diffusa, improve the stability of the efficacy, and the polysaccharide contained in the extract generally has good anti-inflammatory activity and moisturizing effect, so that the skin barrier is repaired while the skin inflammation is relieved, and the synergistic effect of the skin barrier from the outside to the inside and from the inside to the outside is achieved.
2. The effective anti-inflammatory and bacteriostatic components such as alkaloids contained in perfoliate knotweed, amur corktree bark and lightyellow sophora root are used for preparing the extract, so that the extract has excellent effects of calming and relieving itching, the perfoliate knotweed, the amur corktree bark and the lightyellow sophora root which are subjected to low-temperature freeze-thaw treatment are extracted in a water vapor extraction device until no essential oil appears, all water-soluble substances in a plant body are respectively blended into the three extracts, and about 0.3-0.5% of water-soluble components of the essential oil are contained, so that the fragrance of the essential oil can be still kept, the essential oil does not need to be added, meanwhile, the three extracts contain plant essences which are not contained in the essential oil, such as tannic acid and flavonoid, so that the liquid of the extracts has the effect of conditioning the skin, and the liquid of the extracts is easier to; wherein the perfoliate knotweed contains organic acids such as behenyl phenol, methyl caffeate, caffeic acid, protocatechuic acid, p-coumaric acid and the like, not only can play a role in inhibiting bacteria and relieving itching with other components in a synergistic manner, but also can promote the metabolism of keratinocytes and remove the cutin; the main components of the phellodendron bark are alkaloids such as berberine, magnoflorine, phellodendrine, tetrandrine and the like, the phellodendron bark is added into a washing and protecting product to be beneficial to reducing the stimulation of surface active components to the skin, and a small amount of alkaloids can tighten capillary vessels and connective tissues when being combined with saponin and glycoside thereof, also has the effects of stimulating microcirculation, resisting inflammation and inhibiting bacteria, and is commonly used for treating the skin with the tendency of acne; the sophora flavescens belongs to tetracyclothiazine alkaloids, can inhibit the generation of ananaphylaxis factors such as TSLP (total TSLP), eotaxin and the like, inhibit the generation of pruritus, inhibit the release of inflammatory factors such as 5-hydroxytryptamine and the like by combining the sedative and antipruritic effects of flavonoid substances in other extracts, and synergistically improve the skin pruritus state.
3. The invention adopts liquid nitrogen low-temperature extraction treatment to the whole plant of phyllanthus urinaria, perfoliate knotweed, phellodendron bark, lightyellow sophora root, Chinese violet and spreading hedyotis herb, breaks plant cell walls under the state of repeated freeze thawing, enables all components in the plant cell walls to flow out, ensures that active ingredients in the plant cell walls can be retained to the maximum extent under the low-temperature state, improves the utilization rate of medicinal materials and greatly shortens the time of the subsequent extraction process.
4. According to the invention, the Phyllanthus urinaria L extract, the Viola yedoensis Makino extract and the Hedyotis diffusa Makino extract are used as a main reaction system, and the perfoliate knotweed herb extract, the phellodendron amurense extract and the sophora flavescens ait are used as auxiliary reaction systems to be compounded to obtain the plant composition, wherein an extracting solution formed by the main reaction system and an extracting solution formed by the auxiliary reaction systems can be mutually used as secondary extraction solvents to prepare the plant composition, and effective components dissolved in alcohol in the extracts can be combined with water-soluble components in the extracts, so that the compound system is more stable, is suitable for being added into formulas of various formulations, and has wider.
Detailed Description
In order to better understand the present invention, the following embodiments are further described, the examples are only used for explaining the present invention, and do not limit the present invention in any way; unless otherwise specified, the raw materials used in the examples are commercially available except for the bacteriostatic antipruritic important composition of the present invention.
Example 1
The bacteriostatic and itching-relieving plant composition comprises the following raw materials in parts by weight: 8 parts of common leafflower herb extract, 5 parts of perfoliate knotweed herb extract, 12 parts of amur corktree bark extract, 9 parts of lightyellow sophora root extract, 12 parts of Chinese violet extract, 4 parts of spreading hedyotis herb extract and 52 parts of deionized water.
The steps for preparing the bacteriostatic itching-relieving plant composition are as follows:
a preparation method of a bacteriostatic and itching-relieving plant composition specifically comprises the following steps:
(1) pretreatment: cleaning whole plant of Phyllanthus urinaria, perfoliate knotweed, phellodendron, radix sophorae flavescentis, herba violae and oldenlandia diffusa, drying, crushing, sieving with a 30-mesh sieve, packaging the obtained Chinese herbal medicine powder with 100% terylene cloth, quickly freezing in liquid nitrogen in a Dewar bottle, quickly taking out after 1min, putting into a boiling water solution, unfreezing for 12min, and freezing-unfreezing repeatedly;
(2) respectively putting the underleaf pearl powder and the oldenlandia diffusa powder which are subjected to low-temperature freeze thawing treatment into containers, adding 5 times of ethanol solution with the mass concentration of 75%, leaching at room temperature, shaking once every 2.5 hours, performing suction filtration after 6 hours, and collecting filtrate; repeatedly leaching for 1 time, mixing filtrates, placing in a rotary evaporation evaporator at 65 deg.C and 0.90atm, concentrating under reduced pressure, and evaporating to remove solvent to obtain Phyllanthus urinaria extract and herba Hedyotidis Diffusae extract;
(3) adding distilled water into the herba Violae powder subjected to low-temperature freeze thawing treatment according to the solid-to-liquid ratio of 1:20, extracting for 3 times by using a condensation reflux method, setting the temperature of a water bath kettle to be 70 ℃, and setting the time for single extraction to be 2.5 h; filtering under reduced pressure after each extraction is finished, combining the two filtrates, transferring the combined filtrates into a rotary evaporator, concentrating the combined filtrates under reduced pressure to one third of the volume of the original solution, adding 3 times of 85% ethanol into the concentrated mixed solution for precipitation for 26 hours, filtering under reduced pressure, and drying the obtained precipitate in a vacuum freeze dryer to obtain the herba Violae extract;
(4) extracting herba Polygoni Perfoliati, cortex Phellodendri and radix Sophorae Flavescentis after low temperature freeze thawing treatment in a steam extraction device until no essential oil appears, and separating essential oil and extract to obtain herba Polygoni Perfoliati extract, cortex Phellodendri extract and radix Sophorae Flavescentis extract respectively;
(5) the perfoliate knotweed herb extract, the phellodendron extract, the sophora flavescens extract, the Chinese violet extract, the spreading hedyotis herb extract and deionized water are mixed according to the weight ratio of the raw materials to obtain the traditional Chinese medicine extract with the functions of inhibiting bacteria and relieving itching.
Example 2
The bacteriostatic and itching-relieving plant composition comprises the following raw materials in parts by weight: 5 parts of common leafflower herb extract, 3 parts of perfoliate knotweed herb extract, 6 parts of amur corktree bark extract, 5 parts of lightyellow sophora root extract, 8 parts of Chinese violet extract, 3 parts of spreading hedyotis herb extract and 70 parts of deionized water.
The steps for preparing the bacteriostatic itching-relieving plant composition are as follows:
a preparation method of a bacteriostatic and itching-relieving plant composition specifically comprises the following steps:
(1) pretreatment: cleaning whole plant of Phyllanthus urinaria, perfoliate knotweed, phellodendron, radix sophorae flavescentis, herba violae and oldenlandia diffusa, drying, crushing, sieving with a 30-mesh sieve, packaging the obtained Chinese herbal medicine powder with 100% terylene cloth, quickly freezing in liquid nitrogen in a Dewar bottle, quickly taking out after 1min, putting into a boiling water solution, unfreezing for 10min, and freezing-unfreezing repeatedly;
(2) respectively putting the phyllanthus urinaria powder and the oldenlandia diffusa powder which are subjected to low-temperature freeze thawing treatment into containers, adding 5 times of ethanol solution with the mass concentration of 75%, leaching at room temperature, shaking once every 2 hours, performing suction filtration after 6 hours, and collecting filtrate; repeatedly leaching for 1 time, mixing filtrates, placing in rotary evaporation evaporator at 60 deg.C under 0.95atm, concentrating under reduced pressure, and evaporating to remove solvent to obtain Phyllanthus urinaria extract and herba Hedyotidis Diffusae extract;
(3) adding distilled water into the herba Violae powder subjected to low-temperature freeze thawing treatment according to the solid-to-liquid ratio of 1:20, extracting for 3 times by using a condensation reflux method, setting the temperature of a water bath kettle to be 70 ℃, and setting the time for single extraction to be 2 hours; filtering under reduced pressure after each extraction is finished, combining the two filtrates, transferring the combined filtrates into a rotary evaporator, concentrating the combined filtrates under reduced pressure to one third of the volume of the original solution, adding 3 times of 85% ethanol into the concentrated mixed solution for precipitation for 24 hours, filtering under reduced pressure, and drying the obtained precipitate in a vacuum freeze dryer to obtain the herba Violae extract;
(4) extracting herba Polygoni Perfoliati, cortex Phellodendri and radix Sophorae Flavescentis after low temperature freeze thawing treatment in a steam extraction device until no essential oil appears, and separating essential oil and extract to obtain herba Polygoni Perfoliati extract, cortex Phellodendri extract and radix Sophorae Flavescentis extract respectively;
(5) the perfoliate knotweed herb extract, the phellodendron extract, the sophora flavescens extract, the Chinese violet extract, the spreading hedyotis herb extract and deionized water are mixed according to the weight ratio of the raw materials to obtain the traditional Chinese medicine extract with the functions of inhibiting bacteria and relieving itching.
Example 3
The bacteriostatic and itching-relieving plant composition comprises the following raw materials in parts by weight: 10 parts of common leafflower herb extract, 10 parts of perfoliate knotweed herb extract, 15 parts of amur corktree bark extract, 10 parts of lightyellow sophora root extract, 9 parts of Chinese violet extract, 6 parts of spreading hedyotis herb extract and 37 parts of deionized water.
The steps for preparing the bacteriostatic itching-relieving plant composition are as follows:
a preparation method of a bacteriostatic and itching-relieving plant composition specifically comprises the following steps:
(1) pretreatment: cleaning whole plant of Phyllanthus urinaria, perfoliate knotweed, phellodendron, radix sophorae flavescentis, herba violae and oldenlandia diffusa, drying, crushing, sieving with a 30-mesh sieve, packaging the obtained Chinese herbal medicine powder with 100% terylene cloth, quickly freezing in liquid nitrogen in a Dewar bottle, quickly taking out after 2min, putting into a boiling water solution, unfreezing for 12min, and freezing-unfreezing repeatedly;
(2) respectively putting the phyllanthus urinaria powder and the oldenlandia diffusa powder which are subjected to low-temperature freeze thawing treatment into containers, adding 5 times of ethanol solution with the mass concentration of 75%, leaching at room temperature, shaking once every 3 hours, performing suction filtration after 6 hours, and collecting filtrate; repeatedly leaching for 1 time, mixing filtrates, placing in a rotary evaporation evaporator at 65 deg.C and 0.90atm, concentrating under reduced pressure, and evaporating to remove solvent to obtain Phyllanthus urinaria extract and herba Hedyotidis Diffusae extract;
(3) adding distilled water into the herba Violae powder subjected to low-temperature freeze thawing treatment according to the solid-to-liquid ratio of 1:20, extracting for 3 times by using a condensation reflux method, setting the temperature of a water bath kettle to be 75 ℃, and setting the time for single extraction to be 3 h; filtering under reduced pressure after each extraction is finished, combining the two filtrates, transferring the combined filtrates into a rotary evaporator, concentrating the combined filtrates under reduced pressure to one third of the volume of the original solution, adding 3 times of 85% ethanol into the concentrated mixed solution for precipitation for 30 hours, filtering under reduced pressure, and drying the obtained precipitate in a vacuum freeze dryer to obtain the herba Violae extract;
(4) extracting herba Polygoni Perfoliati, cortex Phellodendri and radix Sophorae Flavescentis after low temperature freeze thawing treatment in a steam extraction device until no essential oil appears, and separating essential oil and extract to obtain herba Polygoni Perfoliati extract, cortex Phellodendri extract and radix Sophorae Flavescentis extract respectively;
(5) the perfoliate knotweed herb extract, the phellodendron extract, the sophora flavescens extract, the Chinese violet extract, the spreading hedyotis herb extract and deionized water are mixed according to the weight ratio of the raw materials to obtain the traditional Chinese medicine extract with the functions of inhibiting bacteria and relieving itching.
Example 4
The bath foam containing the plant composition with the functions of inhibiting bacteria and relieving itching at least comprises, by weight, 15 parts of AES, 10-15 parts of sodium lauroyl glutamate, 4 parts of the plant composition with the functions of inhibiting bacteria and relieving itching, 10 parts of glycerol, 0.15 part of phenoxyethanol, 0.2 part of sodium benzoate, 2 parts of hydroxypropyl methyl cellulose, 0.02 part of essence and 70 parts of deionized water.
Example 5
The bath foam containing the plant composition for inhibiting and relieving itching at least comprises, by weight, 20 parts of AES, 15 parts of sodium lauroyl glutamate, 5 parts of the plant composition for inhibiting and relieving itching, 15 parts of glycerol, 0.2 part of phenoxyethanol, 0.3 part of sodium benzoate, 4 parts of hydroxypropyl methyl cellulose, 0.5 part of essence and 40 parts of deionized water.
Example 6
The bath foam containing the plant composition with the functions of inhibiting bacteria and relieving itching at least comprises, by weight, 10 parts of AES, 13 parts of sodium lauroyl glutamate, 2 parts of the plant composition with the functions of inhibiting bacteria and relieving itching, 7-parts of glycerol, 0.01 part of phenoxyethanol, 0.01 part of sodium benzoate, 0.5 part of thickening agent, 0.001 part of essence and 60 parts of deionized water.
Example 7
The preparation method of the bath foam containing the bacteriostatic and itching-relieving plant composition in the embodiments 4 to 6 comprises the following steps:
(1) weighing a certain weight part of deionized water, adding into a batching pot, heating to 75 ℃, sequentially adding a certain weight part of AES, an amino acid surfactant, glycerol, a traditional Chinese medicine bacteriostatic itching-relieving agent and a thickening agent, and uniformly mixing;
(2) after all the raw materials are dissolved, starting cooling water for cooling, stirring at the speed of 50r/min, adding a certain weight part of essence and preservative when the temperature is 45 ℃, and continuously cooling to 35 ℃ to obtain the bath foam containing the bacteriostatic and itching-relieving plant composition.
Example 8
The application of the bacteriostatic itching-relieving plant composition in body milk comprises the raw materials of, by weight, 8 parts of an emulsifier, 15 parts of an emollient, 6 parts of the bacteriostatic itching-relieving plant composition, 10 parts of a humectant, 0.2 part of a thickener, 0.05 part of a pH regulator, 0.08 part of a preservative, 0.05 part of an essence and 50 parts of deionized water.
Further, the emulsifier is 8 parts of cetearyl alcohol; the emollient is 8 parts of shea butter, 5 parts of camellia seed oil and 2 parts of caprylic triglyceride; the humectant is 10 parts of sodium hyaluronate; 0.2 part of xanthan gum is used as the thickening agent; the pH regulator is 0.05 part of EDTA disodium; the preservative is 0.08 part of sodium benzoate.
Example 9
The application of the bacteriostatic itching-relieving plant composition in body milk comprises the raw materials of, by weight, 2 parts of an emulsifier, 10 parts of an emollient, 5 parts of the bacteriostatic itching-relieving plant composition, 8 parts of a humectant, 0.1 part of a thickener, 0.01 part of a pH regulator, 0.05 part of a preservative, 0.001 part of an essence and 40 parts of deionized water.
Further, the emulsifier is 2 parts of cetearyl olive oleate; the emollient is 7 parts of shea butter, 1 part of polydimethylsiloxane and 2 parts of camellia seed oil; the humectant is 3 parts of dipropylene glycol, 2 parts of glycerol and 3 parts of betaine; the thickening agent is 0.1 part of xanthan gum; the pH regulator is 0.01 part of EDTA disodium; the preservative is 0.05 part of sodium benzoate.
Example 10
The application of the bacteriostatic itching-relieving plant composition in body milk comprises the raw materials of, by weight, at least 10 parts of an emulsifier, 20 parts of an emollient, 8 parts of the bacteriostatic itching-relieving plant composition, 11 parts of a humectant, 0.5 part of a thickener, 0.1 part of a pH regulator, 1 part of a preservative, 0.1 part of an essence and 60 parts of deionized water.
Further, the emulsifier is 5 parts of cetearyl olive oleate, 2 parts of lecithin hydroxyethyl acrylate and 3 parts of cetearyl alcohol; the emollient is 10 parts of shea butter, 3 parts of polydimethylsiloxane, 4 parts of camellia seed oil and 3 parts of caprylic triglyceride; the humectant is 1 part of dipropylene glycol, 2 parts of glycerol and 8 parts of sodium hyaluronate; the thickening agent is 0.5 part of xanthan gum; the pH regulator is 0.1 part of EDTA disodium; the preservative is 1 part of sodium benzoate.
Example 11
The preparation method of the body lotion containing the bacteriostatic and antipruritic plant composition in the embodiments 9 to 10 comprises the following steps:
(1) weighing emulsifier and emollient, adding into oil phase pan, mixing to obtain phase A raw material, and heating to 80-85 deg.C;
(2) adding deionized water, thickener and humectant into water phase pot, mixing to obtain phase B, and heating to 80-85 deg.C.
(3) Sequentially pumping A, B phase raw materials into an emulsifying pot, and homogenizing and stirring at 3000r/min for 15 min; keeping the temperature for 15min, and then cooling, and keeping the vacuum degree at-0.08 MPa;
(4) cooling to 45-50 deg.C, adding antibacterial and antipruritic plant composition, pH regulator, antiseptic, and essence, and mixing to obtain body lotion containing antibacterial and antipruritic plant composition.
Evaluation experiment
1. Evaluation of physical and chemical indexes
The characteristics are as follows: the bacteriostatic and antipruritic plant compositions prepared according to the raw material formulas of examples 1 to 3 were observed to have uniform texture, light plant fragrance, and light green liquid.
Checking the pH value: the bacteriostatic and antipruritic plant compositions prepared according to examples 1 to 3 were measured at 25 ℃ by a pH meter, respectively, and the pH values were all measured to be weak acids between 5.2 and 6.5.
Cold resistance test: the bacteriostatic and antipruritic plant compositions prepared according to examples 1 to 3 were respectively sealed in containers, kept in a refrigerator at-4 ℃ for 24 hours, and recovered to room temperature, and then the differences in asexual shape from those before the test were obtained.
Heat resistance test: the bacteriostatic and antipruritic plant compositions prepared according to examples 1 to 3 are respectively filled in containers and sealed, kept in a thermostat at 40 ℃ for 24 hours, and no oil separation and water separation phenomenon occurs after the room temperature is recovered.
And (3) centrifugal test: the bacteriostatic and itching-relieving plant compositions prepared according to the examples 1 to 3 are respectively placed in a centrifuge at 3500r/min and centrifuged for 30min, and no layering phenomenon exists.
The bacteriostatic and antipruritic plant compositions prepared according to examples 1 to 3 were sterilized, separately sealed and packaged, and stored at room temperature, and the plant compositions were considered to be stable without mildew and odor after three months.
2. Security assessment
Test subjects: bacteriostatic and antipruritic botanical compositions prepared according to example 1.
The test population: 40, between 15-30 years old, 20 women, 20 men.
The healthy subject has no allergic history of skin diseases and accords with the volunteer selection standard of the subject.
The spot pasting method comprises the following steps: selecting a qualified spot tester, and putting about 0.020-0.025 g of a tested object into the spot tester in a closed spot test mode, wherein a control hole is blank; the sample and blank control were applied to the curved side of the forearm of the subject for 24h, the patch was removed and the interval was 30min, and the skin reaction was observed after the indentation disappeared. And observing the skin reaction once again after 24h and 48h of the patch test respectively, and recording the result according to the skin reaction grading standard in the cosmetic hygiene standard.
TABLE 1 skin grading Standard
The result of the human body skin patch test shows that 40 subjects pass the plant composition patch test of the invention, and observe skin reaction after 24 hours, wherein 0 case has adverse skin reaction, which indicates that the plant composition used in the test is safe.
3. Test for antibacterial Effect
The tested strains: staphylococcus aureus, Escherichia coli, Candida albicans
Test subjects: bacteriostatic and antipruritic plant compositions prepared in examples 1 to 3.
The test method comprises the following steps: dissolving the slant bacteria cultured in advance in 3ml sterile water in an ultra-clean bench, pouring the bacteria liquid into a clean conical flask for later use, sucking 150 mul of the bacteria liquid and a disposable culture medium by a pipette gun, and uniformly coating the bacteria liquid by an applicator. Sealing the culture medium with sealing film, placing the culture medium in a constant temperature incubator at 37 deg.C for one day without turning over. Slightly placing the sterilized Oxford cup on a culture medium in a clean bench, accurately weighing 0.05g of sample, adding the sample into the Oxford cup, placing the Oxford cup into a constant-temperature incubator at 37 ℃ for two days without sealing and reversing the culture medium, and measuring the inhibition zone.
The results are shown in table 2 below:
TABLE 2 botanical composition zone of inhibition record
| Group of | Staphylococcus aureus | Escherichia coli | Candida albicans |
| Example 1 | 19.0mm | 15.0mm | 18.0mm |
| Example 2 | 14.0mm | 13.5mm | 11.0mm |
| Example 3 | 15.0mm | 12.0mm | 13.0mm |
According to the judgment standard of the antibacterial ring test: the diameter of the antibacterial ring is more than 20mm, so that the antibacterial ring is extremely sensitive; high sensitivity is achieved when the thickness is 15-20 mm; 10-15 mm, medium sensitivity; 7-9 mm is low sensitivity; less than 7mm, was not sensitive. As can be seen from the table, examples 1, 2 and 3 all have good inhibitory effects on Staphylococcus aureus, Escherichia coli and Candida albicans, and the overall effect of example 1 is the best, wherein example 1 has the greatest inhibitory effect on Staphylococcus aureus, which is the main bacterial strain causing itch in human body. The invention has good antibacterial effect, thereby achieving the effect of relieving itching.
4. Itching relieving effect research-histamine phosphate itching relieving method
4.1 Experimental materials
Experimental animals: 32 guinea pigs, half male and female, 350 + -20 g.
And (3) testing a sample: the amount of bacteriostatic and antipruritic botanical composition prepared according to example 1: the high dose group is 1.0 g/Kg; the medium dose group is 0.6 g/Kg; the low dose group was 0.2 g/Kg.
Model control group: and (4) distilled water.
4.2 Experimental methods
(1) 32 guinea pigs were collected, shaved on the dorsum of the right and rear feet 1 day before the experiment, and randomly divided into 4 groups, i.e., the bacteriostatic and antipruritic plant composition high dose group, medium dose group, low dose group and model control group prepared in example 1.
(2) And uniformly smearing the corresponding dosage sample and the model control group on the shaved part respectively for 2 days.
(3) On the 3 rd day of the experiment, a proper amount of histamine phosphate is precisely weighed and prepared into … … gradient concentrations with the volume percentage of 0.01 percent, 0.02 percent, 0.03 percent and 0.04 percent by using distilled water for standby application before use; scratching the shaved part of the right hind instep of the guinea pig with coarse sand paper to an area of about 1cm2, topically applying the medicine for 1 time, dripping 0.01% histamine phosphate 0.05mL at the scratched part 10min after the last application, and gradually increasing the concentration according to 0.01%, 0.02%, 0.03% and 0.04% … … every 3 min, wherein each time is 0.05 mL; until the guinea pig licks the right hind paw, the scratchiness threshold was determined as the average of the total amount of histamine phosphate dripped when the guinea pig licks the right hind paw.
(4) The itch thresholds were calculated for each group and the differences between groups were compared.
TABLE 3 Effect of Histamine Phosphorate in Guinea pigs on the itchy response (x. + -.s, n. RTM. 6)
| Group of | Dosage (g/kg) | Itch threshold (mug) |
| Model set | 0 | 25.8±13.6 |
| High dose in sample groups | 1.0 | 104.8±15.7* |
| Dose in sample group | 0.6 | 81.4±10.1 |
| Low dose in sample group | 0.2 | 44.6±6.7 |
Note: p <0.05, p <0.01 compared to model controls.
As can be seen from the above table, the sample group had a significant inhibitory effect on the itch-induced reaction of guinea pig histamine phosphate compared to the model group (. about.p < 0.05). Wherein, the plant composition prepared in example 1 has a significant inhibitory effect (/ p < 0.05); the inventor uses the bacteriostatic and antipruritic plant compositions prepared in the embodiments 2 and 3 to carry out the same experiment, and obtains the same conclusion; the plant composition prepared by the invention has good itching relieving effect.
5. The bath foam containing the bacteriostatic and antipruritic plant composition prepared in example 5 and the body lotion containing the bacteriostatic and antipruritic plant composition prepared in example 8 were subjected to the applicability test as follows:
5.1 subjects: 50 sensitive and itching-prone volunteers aged 18-60 years have a male-female ratio of 1: 1.
5.2 Experimental methods: the composition is divided into two groups, wherein the volunteers in the experimental group take bath with bath lotion containing antibacterial and antipruritic composition at night for 30 days, and the experimental group II uses bath lotion and body lotion for 30 days. The total score of the using effect of each item is 5, and 5 is the highest score, so that the score is better and very satisfactory; 4, the classification is very good; 3 is acceptable; 2, the classification is not good and cannot be accepted; 1 score was very poor and completely intolerable, with the results shown in Table 4 below:
table 4 usage effect scoring
| Effects of use | Experiment set 1 | Experiment group two |
| Feeling of tightness of skin | 4.6 | 4.8 |
| Can be used for treating skin redness | 4.3 | 4.4 |
| Can be used for treating skin red swelling | 4.4 | 4.4 |
| Solves the skin pimple | 4.3 | 4.6 |
| Solving the problem of skin dermatitis (not damaged) | 4.1 | 4.2 |
As can be seen from the table above, the bath foam and the body lotion prepared from the plant composition for inhibiting bacteria and relieving itching have good moisturizing and itching relieving effects, and can effectively solve the problem of skin itching in daily life. And the bath foam is matched with the body lotion for use, has better effect and is particularly suitable for people with sensitive skin and easy pruritus.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (8)
1. The bacteriostatic and itching-relieving plant composition is characterized by comprising the following raw materials in parts by weight: 5-10 parts of phyllanthus urinaria extract, 3-10 parts of perfoliate knotweed extract, 6-15 parts of phellodendron extract, 5-10 parts of sophora flavescens extract, 8-12 parts of philippine violet herb extract, 3-6 parts of spreading hedyotis herb extract and 37-70 parts of deionized water.
2. The preparation method of the bacteriostatic and antipruritic plant composition according to claim 1, which comprises the following steps:
(1) pretreatment: cleaning and drying whole phyllanthus urinaria, perfoliate knotweed herb, golden cypress, lightyellow sophora root, Chinese violet and spreading hedyotis herb, crushing and sieving by a 30-mesh sieve, packaging the obtained Chinese herbal medicine powder by 100% terylene cloth, placing the packaged Chinese herbal medicine powder into liquid nitrogen in a Dewar bottle, quickly freezing the packaged Chinese herbal medicine powder for 1 to 2min, quickly taking the packaged Chinese herbal medicine powder out, putting the packaged Chinese herbal medicine powder into a boiling water solution, unfreezing the Chinese herbal medicine powder for 10 to 12min, and carrying out freezing;
(2) respectively putting the phyllanthus urinaria powder and the oldenlandia diffusa powder which are subjected to low-temperature freeze thawing treatment into containers, adding 5 times of ethanol solution with the mass concentration of 75%, leaching at room temperature, shaking once every 2-3 h, performing suction filtration after 6h, and collecting filtrate; repeatedly leaching for 1 time, combining filtrates, placing in a rotary evaporator at 60-65 deg.C under 0.90-0.95 atm, concentrating under reduced pressure, and evaporating to remove solvent to obtain Phyllanthus urinaria extract and herba Hedyotidis Diffusae extract;
(3) adding distilled water into the Chinese violet powder subjected to low-temperature freeze thawing treatment according to the solid-to-liquid ratio of 1:20, extracting for 3 times by using a condensation reflux method, setting the temperature of a water bath kettle to be 70-75 ℃, and setting the time for single extraction to be 2-3 h; filtering under reduced pressure after each extraction is finished, combining the two filtrates, transferring the combined filtrates into a rotary evaporator, concentrating the combined filtrates under reduced pressure to one third of the volume of the original solution, adding 3 times of 85% ethanol in the concentrated mixed solution for precipitation for 24-30 h, filtering under reduced pressure, and drying the obtained precipitate in a vacuum freeze dryer to obtain the herba violae extract;
(4) extracting herba Polygoni Perfoliati, cortex Phellodendri and radix Sophorae Flavescentis after low temperature freeze thawing treatment in a steam extraction device until no essential oil appears, and separating essential oil and extract to obtain herba Polygoni Perfoliati extract, cortex Phellodendri extract and radix Sophorae Flavescentis extract respectively;
(5) mixing Phyllanthus urinaria extract, herba Polygoni Perfoliati extract, cortex Phellodendri extract, radix Sophorae Flavescentis extract, herba Violae extract, herba Hedyotidis Diffusae extract, and deionized water at a certain weight ratio to obtain Chinese medicinal extract with antibacterial and antipruritic effects.
3. The application of the bacteriostatic itching-relieving plant composition to the preparation of daily care products for skin pruritus as claimed in claim 1, wherein the bacteriostatic itching-relieving plant composition comprises the following components in percentage by weight: the addition amount of the bacteriostatic itching-relieving plant composition is 2-10%.
4. Use of a bacteriostatic antipruritic composition comprising the plant according to claim 1 in a body wash, wherein the plant comprises: the bath foam containing the plant composition for inhibiting and relieving itching at least comprises, by weight, 10-20 parts of AES, 10-15 parts of amino acid surfactant, 2-5 parts of the plant composition for inhibiting and relieving itching, 7-15 parts of glycerol, 0.02-0.5 part of preservative, 0.5-4 parts of thickener, 0.001-0.5 part of essence and 40-70 parts of deionized water.
5. The use of a herbal bacteriostatic antipruritic composition in a body wash according to claim 4 wherein: the amino acid surfactant is sodium lauroyl glutamate; the thickening agent is hydroxypropyl methyl cellulose.
6. The use of a herbal bacteriostatic antipruritic composition in a body wash according to claim 4 wherein: the preservative is a compound product of phenoxyethanol and sodium phenylpropionate.
7. Use in body milk of a bacteriostatic antipruritic botanical composition according to claim 1, characterized in that: the body lotion containing the bacteriostatic and antipruritic plant composition at least comprises, by weight, 2-10 parts of an emulsifier, 10-20 parts of an emollient, 5-8 parts of the bacteriostatic and antipruritic plant composition, 8-11 parts of a humectant, 0.1-0.5 part of a thickener, 0.01-0.1 part of a pH regulator, 0.05-1 part of a preservative, 0.001-0.1 part of an essence and 40-60 parts of deionized water.
8. The use of a bacteriostatic antipruritic composition comprising plant matter as claimed in claim 7 in body milk wherein: the emulsifier is one or more of cetearyl olive oleate, lecithin hydroxyethyl acrylate and cetearyl alcohol; the emollient is one or more of shea butter, polydimethylsiloxane, camellia seed oil and caprylic triglyceride; the humectant is one or more of dipropylene glycol, glycerol, betaine and sodium hyaluronate; the thickening agent is xanthan gum; the pH regulator is EDTA disodium; the preservative is sodium benzoate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110261720.3A CN113018233A (en) | 2021-03-10 | 2021-03-10 | Bacteriostatic and itching-relieving plant composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110261720.3A CN113018233A (en) | 2021-03-10 | 2021-03-10 | Bacteriostatic and itching-relieving plant composition and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113018233A true CN113018233A (en) | 2021-06-25 |
Family
ID=76469391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110261720.3A Pending CN113018233A (en) | 2021-03-10 | 2021-03-10 | Bacteriostatic and itching-relieving plant composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113018233A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114539259A (en) * | 2022-02-24 | 2022-05-27 | 深圳海创生物科技有限公司 | Active alkaloid compound, radix Sophorae Flavescentis extract and its application in preparing product with skin pruritus resisting effect |
| CN115245539A (en) * | 2021-09-26 | 2022-10-28 | 上海江笙生物科技有限公司 | Antibacterial itching-relieving health-care foot spray and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101115493A (en) * | 2005-08-12 | 2008-01-30 | 河乃建仁 | Agent for hair growth |
| CN102430035A (en) * | 2011-12-06 | 2012-05-02 | 北京工商大学 | Chinese medicinal composition and preparation with effects of relieving allergy and itching and preparation methods thereof |
| CN103432536A (en) * | 2013-09-27 | 2013-12-11 | 唐荣兰 | Traditional Chinese medicine composition for treating acne and preparation method thereof |
| CN109288931A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating infant eczema, preparation and preparation method and application |
| KR20190132032A (en) * | 2018-05-18 | 2019-11-27 | 국립낙동강생물자원관 | Composition for Anti-inflammation Using Extract of Salix sp. Plant |
| CN111012833A (en) * | 2019-12-11 | 2020-04-17 | 上海萱蕙生物科技有限公司 | Pure plant source bacteriostatic agent, preparation method and application thereof, and spray liquid |
| CN111096940A (en) * | 2020-02-19 | 2020-05-05 | 云南群优生物科技有限公司 | Mite-removing itching-relieving hair washing preparation containing sweet wormwood |
| CN111184844A (en) * | 2018-10-26 | 2020-05-22 | 王志成 | Herbal bacteriostatic cream |
| CN111870568A (en) * | 2020-07-13 | 2020-11-03 | 北京安德普泰医疗科技有限公司 | Anti-allergy itching-relieving plant composition and preparation method and application thereof |
-
2021
- 2021-03-10 CN CN202110261720.3A patent/CN113018233A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101115493A (en) * | 2005-08-12 | 2008-01-30 | 河乃建仁 | Agent for hair growth |
| CN102430035A (en) * | 2011-12-06 | 2012-05-02 | 北京工商大学 | Chinese medicinal composition and preparation with effects of relieving allergy and itching and preparation methods thereof |
| CN103432536A (en) * | 2013-09-27 | 2013-12-11 | 唐荣兰 | Traditional Chinese medicine composition for treating acne and preparation method thereof |
| KR20190132032A (en) * | 2018-05-18 | 2019-11-27 | 국립낙동강생물자원관 | Composition for Anti-inflammation Using Extract of Salix sp. Plant |
| CN111184844A (en) * | 2018-10-26 | 2020-05-22 | 王志成 | Herbal bacteriostatic cream |
| CN109288931A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating infant eczema, preparation and preparation method and application |
| CN111012833A (en) * | 2019-12-11 | 2020-04-17 | 上海萱蕙生物科技有限公司 | Pure plant source bacteriostatic agent, preparation method and application thereof, and spray liquid |
| CN111096940A (en) * | 2020-02-19 | 2020-05-05 | 云南群优生物科技有限公司 | Mite-removing itching-relieving hair washing preparation containing sweet wormwood |
| CN111870568A (en) * | 2020-07-13 | 2020-11-03 | 北京安德普泰医疗科技有限公司 | Anti-allergy itching-relieving plant composition and preparation method and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 尹显洪: "《瑶医常用植物药化学与药理研究》", 31 August 2008, 广州：广东旅游出版社 * |
| 李绮等: "超声-液氮冻融处理对灵芝孢子粉多糖提取的影响", 《辽宁大学学报(自然科学版)》 * |
| 林丽静等: "超临界和水蒸气提取高良姜精油及纯露的成分研究", 《热带作物学报》 * |
| 范文昌: "《广东地产清热解毒药物大全》", 31 July 2011, 北京：中医古籍出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115245539A (en) * | 2021-09-26 | 2022-10-28 | 上海江笙生物科技有限公司 | Antibacterial itching-relieving health-care foot spray and preparation method thereof |
| CN114539259A (en) * | 2022-02-24 | 2022-05-27 | 深圳海创生物科技有限公司 | Active alkaloid compound, radix Sophorae Flavescentis extract and its application in preparing product with skin pruritus resisting effect |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113398051B (en) | Plant combined extract for removing mites and acnes as well as preparation method and application thereof | |
| CN110755331B (en) | Antibacterial infant washing and caring preparation and application thereof | |
| CN113018233A (en) | Bacteriostatic and itching-relieving plant composition and preparation method and application thereof | |
| CN113081928A (en) | Plant bacteriostatic gel and preparation method and application thereof | |
| CN111228207B (en) | Dampness-rash-eliminating hip-protecting cream and preparation method thereof | |
| CN110638728B (en) | Skin care composition for removing acne and lightening acne marks and preparation method and application thereof | |
| CN109793696B (en) | Anti-dandruff plant composition and preparation method and application thereof | |
| CN109125207B (en) | Plant compound composition for inhibiting bacteria and removing acnes as well as preparation method and application thereof | |
| CN108785200B (en) | Antibacterial, acne-removing and anti-wrinkle silver ion moisturizing mask liquid, mask and preparation method of mask | |
| CN109939193A (en) | A kind of composition for treating skin eczema, preparation and preparation method and application | |
| KR20200065521A (en) | Feminine Cleanser Composition Comprising Natural Antimicrobial Agents | |
| CN115518127B (en) | Antibacterial, anti-inflammatory, detumescence and antipruritic cream and preparation method thereof | |
| CN107137336A (en) | A kind of anti acne of traditional Chinese medicine facial mask and preparation method thereof | |
| KR20010026175A (en) | whitening composition including the natural plant extract | |
| CN110755322A (en) | Jindan anti-allergy traditional Chinese medicine extract and preparation method and application thereof | |
| CN115245476A (en) | Composition for removing dandruff, relieving itching and improving scalp microenvironment and preparation method thereof | |
| CN114306526B (en) | Compound broadleaf holly leaf traditional Chinese medicine extract and application thereof in preparing shower gel or hand sanitizer | |
| CN107049866B (en) | Antiallergic plant composition and application thereof | |
| KR101427462B1 (en) | Composite Natural Antiseptics From Forsythia suspensa Vahl, Leonurus sibiricus L., Crataegi fructus and Akebia quinata Decaisne, Cosmetic Compositions Containing Them | |
| CN108186440A (en) | Can antibiotic skin-care Chinese medicinal plant shower cream and its preparation method and application | |
| CN110141542B (en) | Allergy-relieving agent containing radix pseudostellariae and preparation method thereof | |
| CN108815077B (en) | Traditional Chinese medicine moisturizing hand cream and preparation method thereof | |
| CN113332197A (en) | Plant sunscreen cream and preparation method thereof | |
| KR101125758B1 (en) | A detergent composition for cleaning the women's genital area | |
| KR20170043057A (en) | Composition for wet tissue |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210625 |
|
| RJ01 | Rejection of invention patent application after publication |