CN112587426A - Whitening and freckle removing essence and preparation method thereof - Google Patents
Whitening and freckle removing essence and preparation method thereof Download PDFInfo
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- CN112587426A CN112587426A CN202110017626.3A CN202110017626A CN112587426A CN 112587426 A CN112587426 A CN 112587426A CN 202110017626 A CN202110017626 A CN 202110017626A CN 112587426 A CN112587426 A CN 112587426A
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- whitening
- freckle
- extract
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- root extract
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- 208000003351 Melanosis Diseases 0.000 title claims abstract description 67
- 230000002087 whitening effect Effects 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 14
- GVWGRUCKLWVZRY-ATDBAKNUSA-N (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N.COC1=CC(\C=C\C(O)=O)=CC=C1O GVWGRUCKLWVZRY-ATDBAKNUSA-N 0.000 claims abstract description 10
- 206010014970 Ephelides Diseases 0.000 claims abstract description 8
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims abstract description 8
- 229960004308 acetylcysteine Drugs 0.000 claims abstract description 8
- 239000000654 additive Substances 0.000 claims abstract description 8
- 239000011570 nicotinamide Substances 0.000 claims abstract description 7
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 7
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 7
- 239000003974 emollient agent Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 230000002335 preservative effect Effects 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims description 55
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 12
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 10
- 244000146462 Centella asiatica Species 0.000 claims description 10
- 235000004032 Centella asiatica Nutrition 0.000 claims description 10
- 244000178231 Rosmarinus officinalis Species 0.000 claims description 10
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 10
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 10
- 229960004063 propylene glycol Drugs 0.000 claims description 10
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 9
- 229920002498 Beta-glucan Polymers 0.000 claims description 9
- 244000269722 Thea sinensis Species 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 244000068988 Glycine max Species 0.000 claims description 8
- 235000010469 Glycine max Nutrition 0.000 claims description 8
- 244000042664 Matricaria chamomilla Species 0.000 claims description 8
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 8
- 240000001341 Reynoutria japonica Species 0.000 claims description 8
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 8
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 8
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 7
- 235000007319 Avena orientalis Nutrition 0.000 claims description 7
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 7
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 5
- 239000002562 thickening agent Substances 0.000 claims description 5
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 4
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 244000153955 Reynoutria sachalinensis Species 0.000 claims description 2
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 238000009924 canning Methods 0.000 claims description 2
- 229940070641 chamomile flowers Drugs 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 claims description 2
- 235000007558 Avena sp Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000007794 irritation Effects 0.000 abstract description 5
- 239000000686 essence Substances 0.000 description 27
- 230000000052 comparative effect Effects 0.000 description 22
- 238000012360 testing method Methods 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- 206010020751 Hypersensitivity Diseases 0.000 description 6
- 208000026935 allergic disease Diseases 0.000 description 6
- 230000007815 allergy Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 4
- 206010042496 Sunburn Diseases 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 206010008570 Chloasma Diseases 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- IDUUXROOZBOOPH-QHHAFSJGSA-N 2-{[(2E)-3-(3,4-dihydroxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1NC(=O)\C=C\C1=CC=C(O)C(O)=C1 IDUUXROOZBOOPH-QHHAFSJGSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 229930190481 Avenanthramide Natural products 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- -1 caprylyl hydroxamic Chemical compound 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940092665 tea leaf extract Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a whitening and freckle-removing essence and a preparation method thereof, wherein the essence comprises the following components in percentage by mass: 1% of 4-butyl resorcinol; 0.5-1% of acetylcysteine; 0.2-0.5% of arginine ferulate; 0.2-0.3% of 1-methylhydantoin-2-imide; 2% of nicotinamide; 10-10.5% of an emollient; 1-1.5% of a skin conditioner; 0.5-0.8% of preservative; 0.2-0.3% of other additives; the balance being water. The whitening and freckle-removing essence disclosed by the invention can effectively achieve the effects of whitening and removing freckles, is stable, is not easy to discolor and has low irritation.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a whitening and freckle-removing essence and a preparation method thereof.
Background
At present, a plurality of whitening and freckle-removing cosmetics are available on the market, and can be generally classified into liquids, emulsions, creams, plasters and the like according to dosage forms. The existing whitening and freckle-removing cosmetics cannot achieve the corresponding whitening and freckle-removing effects, the problems of insecurity, adverse reaction and the like exist in the product under the same addition amount, the product stability is poor, and the whitening and freckle-removing cosmetics are not ideal in the aspects of raw material combination and preparation methods. How to reduce the irritation of the whitening and freckle-removing cosmetic and improve the stability of the cosmetic is a problem faced by the prior whitening and freckle-removing cosmetic.
Disclosure of Invention
In view of the defects of the prior art, the first object of the invention is to provide a whitening and freckle-removing essence which can effectively achieve the effects of whitening and removing freckles, is stable, is not easy to discolor and has low irritation.
The second purpose of the invention is to provide a preparation method of the whitening and freckle-removing essence, which can uniformly disperse all raw materials, improve the stability of the product and keep the activity of the raw materials.
In order to achieve the first purpose of the invention, the invention provides a whitening and freckle-removing essence which comprises the following components in percentage by mass: 1% of 4-butyl resorcinol; 0.5-1% of acetylcysteine; 0.2-0.5% of arginine ferulate; 0.2-0.3% of 1-methylhydantoin-2-imide; 2% of nicotinamide; 10-10.5% of an emollient; 1-1.5% of a skin conditioner; 0.5-0.8% of preservative; 0.2-0.3% of other additives; the balance being water.
Preferably, the other additive comprises a chelating agent, which is disodium EDTA.
Preferably, the other additives further comprise a thickener, which is xanthan gum.
Preferably, the mass percent of the chelating agent in the whitening and freckle-removing essence is 0.1%, and the mass percent of the thickening agent in the whitening and freckle-removing essence is 0.1-0.2%.
Preferably, the emollient includes butylene glycol, glycerin, β -glucan, avenanthramide, and sodium hyaluronate; the mass percentage of the butanediol in the whitening and freckle-removing essence is 2.5-3%; the mass percentage of the glycerin in the whitening and freckle-removing essence is 2.5-3%; the mass percentage of the beta-glucan in the whitening and freckle-removing essence is 2-2.5%; the mass percentage of the oat peptide in the whitening and freckle-removing essence is 2-2.5%; the mass percentage of the sodium hyaluronate in the whitening and freckle-removing essence is 0.06-0.08%.
Preferably, the skin conditioning agent comprises tea leaf extract, glycyrrhiza glabra root extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, centella asiatica root extract, rosemary flower and/or leaf and/or stem extract, chamomile flower and/or leaf and/or stem extract, and glycine max seed extract.
Preferably, the mass percentage of the tea extract in the whitening and freckle-removing essence is 0.15-0.2%; the mass percentages of the glycyrrhiza glabra root extract, the polygonum cuspidatum root extract, the scutellaria baicalensis root extract, the centella asiatica root extract, the flower and/or leaf and/or stem extract of rosemary and the chamomile flower and/or leaf and/or stem extract in the whitening and freckle removing essence are respectively 0.1-0.12%; the weight percentage of the wild soybean seed extract is 0.4-0.5%;
preferably, the preservatives include caprylyl hydroxamic acid, ethylhexyl glycerin, 1, 2-hexanediol, and propylene glycol; the mass percentage of the caprylyl hydroximic acid in the whitening and freckle-removing essence is 0.24-0.25%; the mass percentage of the ethylhexyl glycerin in the whitening and freckle-removing essence is 0.25-0.3%; the mass percentage of the 1, 2-hexanediol in the whitening and freckle-removing essence is 0.03-0.05%; the mass percentage of the propylene glycol in the whitening and freckle-removing essence is 0.03-0.05%.
In order to achieve the second object of the invention, the invention provides a preparation method of a whitening and freckle-removing essence, which comprises the following steps:
the method comprises the following steps: respectively preparing raw materials of a phase A, a phase B and a phase C; the raw materials of the phase A comprise first part of water, glycerol, nicotinamide, avenin, xanthan gum, EDTA disodium and sodium hyaluronate, and the raw materials of the phase A are uniformly dispersed at the temperature of more than or equal to 75 ℃; the raw material of the B phase comprises butanediol and 4-butyl resorcinol, and the raw material of the B phase is uniformly dispersed at the temperature of less than or equal to 45 ℃; the raw material of phase C comprises a second part of water, tea extract, glycyrrhiza glabra root extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, centella asiatica root extract, rosemary flower and/or leaf and/or stem extract, chamomile flower and/or leaf and/or stem extract, glycine max seed extract, beta-glucan, 1-methylhydantoin-2-imide, arginine ferulate, caprylhydroxamic acid, ethylhexylglycerin, 1, 2-hexanediol, and propylene glycol; relative to the total mass of the raw materials, the mass percentages of the raw materials are as follows: 1% of 4-butyl resorcinol; 0.5-1% of acetylcysteine; 0.2-0.5% of arginine ferulate; 0.2-0.3% of 1-methylhydantoin-2-imide; 2% of nicotinamide; 0.1% of EDTA disodium; 0.1-0.2% of xanthan gum; 2.5-3% of butanediol; 2.5-3% of glycerol; 2-2.5% of beta-glucan; 2-2.5% of oat peptide; 0.06-0.08% of sodium hyaluronate; 0.15-0.2% of tea extract; 0.1-0.12% of glycyrrhiza glabra root extract; 0.1-0.12% of giant knotweed root extract; 0.1-0.12% of scutellaria root extract; 0.1-0.12% of centella asiatica root extract; 0.1-0.12% of flower and/or leaf and/or stem extract of rosemary; 0.1-0.12% of an extract of chamomile flowers and/or leaves and/or stems; 0.4-0.5% of a wild soybean seed extract; 0.24-0.25% of caprylyl hydroximic acid; 0.25 to 0.3% of ethylhexyl glycerin; 0.03-0.05% of 1, 2-hexanediol; 0.03-0.05% of propylene glycol; the balance of water;
step two: cooling the phase A raw material to 40-45 ℃, adding the phase B raw material and the phase C raw material, and uniformly stirring and dispersing to obtain a mixture;
step three: and cooling the mixture to 35-38 ℃, discharging, standing, and then canning.
Preferably, in the first step, the mass ratio of the first part of water to the second part of water is (25-30): 1.
preferably, in the step one, after the raw material of the phase A is uniformly dispersed at the temperature of more than or equal to 75 ℃, the raw material of the phase A is put into a vacuum emulsification stirrer and stirred for more than 5 minutes at constant temperature under the vacuum condition.
Preferably, in the first step, when the raw material of phase C is dispersed, the second part of water, the tea extract, the glycyrrhiza glabra root extract, the polygonum cuspidatum root extract, the scutellaria baicalensis root extract, the centella asiatica root extract, the rosemary flower and/or leaf and/or stem extract, the chamomile flower and/or leaf and/or stem extract are uniformly mixed, the 1-methylhydantoin-2-imide and the arginine ferulate are uniformly mixed, the caprylhydroxamic acid, the ethylhexyl glycerol, the 1, 2-hexanediol and the propylene glycol are uniformly mixed, and then the three mixtures are mixed with the other raw material of phase C.
Compared with the prior art, the invention can obtain the following beneficial effects:
the whitening and freckle-removing essence disclosed by the invention has the advantages that the consumption of 4-butyl resorcinol is controlled to be 1%, the problem that stimulation is easily caused when the 4-butyl resorcinol is excessively used is solved, the whitening and freckle-removing effects of the 4-butyl resorcinol are improved by using nicotinamide, acetylcysteine, 1-methylhydantoin-2-imide and arginine ferulate in combination with the 4-butyl resorcinol, the pH value of a formula does not need to be reduced, the stimulation is reduced, and the problem that the 4-butyl resorcinol is easily oxidized and discolored in the formula can be solved by combining the raw materials. In addition, a chelating agent EDTA disodium can be added into the formula, so that the antioxidant capacity of the formula is further improved, 4-butylresorcinol is not easy to oxidize, and the stability of the formula is improved.
In the preparation process, the raw materials are divided into an A phase, a B phase and a C phase, wherein the A phase raw material can be heated to a higher temperature, so that the raw materials are fully and uniformly dissolved and are not inactivated due to overhigh temperature; the phase B is a main component for removing spots and whitening, and needs to be independently dissolved and then added into the material body at a low temperature; phase C is an active additive, and the extract is high in content and can only be added at a low temperature of the material body, so that the activity can be ensured. The preparation method of the whitening and freckle-removing essence can disperse all raw materials more uniformly, improve the stability of products, improve the production efficiency and keep the activity of the raw materials.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
Example 1
The raw materials used in this example and their contents, effects, and phases of the mixing process are shown in table 1 below.
Table 1 starting material for example 1
The preparation method of this example includes the following steps:
1. adding the phase A raw material into a water phase pot, stirring and heating to 80 ℃, fully and uniformly stirring, and keeping the temperature for later use;
2. firstly, pumping the phase A raw material into a vacuum emulsification stirrer, continuously stirring, vacuumizing, and keeping the temperature for 10 minutes;
3. cooling to 45 deg.C, adding the raw materials of phase B and phase C, and stirring thoroughly;
4. cooling to 38 deg.C, discharging, and standing;
5. after the inspection is qualified, filling, packaging and code spraying are carried out;
6. and warehousing after the spot check is qualified.
Example 2
The raw materials used in this example and their contents, effects, and phases of the mixing process are shown in table 2 below.
Table 2 starting material for example 2
The preparation method of this example includes the following steps:
1. adding the phase A raw material into a water phase pot, stirring and heating to 85 ℃, fully and uniformly stirring, and keeping the temperature for later use;
2. firstly, pumping the phase A raw material into a vacuum emulsification stirrer, continuously stirring, vacuumizing, and keeping the temperature for 5 minutes;
3. cooling to 40 deg.C, adding the raw materials of phase B and phase C, and stirring thoroughly;
4. cooling to 35 deg.C, discharging, and standing;
5. after the inspection is qualified, filling, packaging and code spraying are carried out;
6. and warehousing after the spot check is qualified.
Comparative example 1
The formulation and preparation method of this comparative example are substantially the same as example 1, except that the amounts of some of the raw materials are different, as shown in table 3 below.
Table 3 difference in amount of raw materials between comparative example 1 and example 1
| Raw materials | Comparative example 1 | Example 1 |
| Beta-glucan | 0 | 2％ |
| Acetylcysteine | 0.5％ | 1％ |
| Nicotinamide | 2％ | 2％ |
| Oat peptide | 0 | 2％ |
| 4-butylresorcinol | 2％ | 1％ |
| Water in phase A | 83.54％ | 80.04％ |
Comparative example 2
The formulation and preparation method of this comparative example are substantially the same as example 1, except that the amounts of some of the raw materials are different, as shown in table 4 below.
Table 4 differences in the amounts of raw materials between comparative example 2 and example 1
| Raw materials | Comparative example 2 | Example 1 |
| Acetylcysteine | 1％ | 1％ |
| Nicotinamide | 2％ | 2％ |
| Oat peptide | 1.5％ | 2％ |
| 4-butylresorcinol | 0.5％ | 1％ |
Comparative example 3
The formulation of this comparative example is the same as example 1 except for the difference in the preparation method, comparative example 3 does not distinguish three groups of raw materials of phase a, phase B and phase C, and the preparation method of comparative example 3 comprises the following steps:
1. putting all the raw materials into a stirring device, heating to 45 ℃, and fully and uniformly stirring;
2. cooling to 38 deg.C, discharging, and standing;
3. after the inspection is qualified, filling, packaging and code spraying are carried out;
4. and warehousing after the spot check is qualified.
The following performance tests, including stability test, allergy test and spot removal effect test, were performed on the essences obtained in the examples and comparative examples.
(1) Stability of
The results are shown in Table 5 below.
Table 5 stability test results
As can be seen from the above, the whitening and freckle-removing essence prepared in the embodiments 1-2 of the present invention has the advantages of stability and no discoloration, whereas in the comparative example 1, excessive 4-butylresorcinol causes the obtained essence to be easily discolored at a slightly higher temperature, and in the comparative example 3, the preparation method of the present invention is not adopted, but a method of mixing all raw materials is adopted, so that the obtained essence is easily delaminated under centrifugation and heating conditions.
(2) Allergy testing
The test is used for counting the number of allergy in the trial results of 50 persons and calculating the allergy rate. The results are shown in Table 6 below.
TABLE 6 allergy test results
As can be seen from the above, examples 1 to 2 of the present invention have a lower allergy rate than comparative example 1 in which 4-butyl resorcinol is used in an excessive amount, mainly because the present invention reduces the amount of 4-butyl resorcinol.
(3) Speckle removing effect test
The test is used for counting the trial results of 80 people, wherein the daily use amount of each person is the same for 30 freckles, 23 chloasma, 25 sunburn and 2 plumbum and mercury spots. The pigment fade was determined by comparison to a blank without any product and the results are shown in table 7 below.
TABLE 7 speckle-removing Effect test results (pigment fading rate/%)
Continuing with Table 7:
from the above, the freckle-removing essence disclosed by the invention has a good freckle-removing effect on freckles, chloasma, sunburn and plumbum and mercury spots, and particularly on sunburn and freckles. Compared with the comparative example 1, the initial freckle removing effect of the comparative example 1 is better, and the freckle removing effect of the embodiment of the invention is equivalent to that of the comparative example 1 after the use time is prolonged, but the embodiment of the invention overcomes the defects of strong irritation, easy discoloration and the like of the comparative example 1. The spot-removing effect of comparative example 2 was inferior to that of comparative example 2.
In conclusion, the whitening and freckle-removing essence disclosed by the invention is stable, does not change color, has low irritation and has a better whitening and freckle-removing effect.
Finally, it should be emphasized that the above-described embodiments are merely preferred examples of the invention, which is not intended to limit the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The whitening and freckle-removing essence is characterized by comprising the following components in percentage by mass: 1% of 4-butyl resorcinol; 0.5-1% of acetylcysteine; 0.2-0.5% of arginine ferulate; 0.2-0.3% of 1-methylhydantoin-2-imide; 2% of nicotinamide; 10-10.5% of an emollient; 1-1.5% of a skin conditioner; 0.5-0.8% of preservative; 0.2-0.3% of other additives; the balance being water.
2. The whitening and freckle-removing essence according to claim 1, which is characterized in that:
the other additives include a chelating agent, which is disodium EDTA.
3. The whitening and freckle-removing essence according to claim 2, which is characterized in that:
the other additives also comprise a thickening agent, and the thickening agent is xanthan gum.
4. The whitening and freckle-removing essence according to claim 3, which is characterized in that:
the mass percentage of the chelating agent in the whitening and freckle-removing essence is 0.1%, and the mass percentage of the thickening agent in the whitening and freckle-removing essence is 0.1-0.2%.
5. The essence for whitening and removing freckles according to any one of claims 1 to 4, which is characterized in that:
the emollient comprises butylene glycol, glycerin, beta-glucan, oat peptide and sodium hyaluronate;
the mass percentage of the butanediol in the whitening and freckle-removing essence is 2.5-3%;
the mass percentage of glycerin in the whitening and freckle-removing essence is 2.5-3%;
the mass percentage of the beta-glucan in the whitening and freckle-removing essence is 2-2.5%;
the mass percentage of the avenin in the whitening and freckle-removing essence is 2-2.5%;
the mass percentage of the sodium hyaluronate in the whitening and freckle-removing essence is 0.06-0.08%.
6. The essence for whitening and removing freckles according to any one of claims 1 to 4, which is characterized in that:
the skin conditioner comprises tea extract, Glycyrrhiza glabra root extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, centella asiatica root extract, rosemary flower and/or leaf and/or stem extract, Matricaria chamomilla flower and/or leaf and/or stem extract, and Glycine max seed extract.
7. The whitening and freckle-removing essence according to claim 6, which is characterized in that:
the mass percentage of the tea extract in the whitening and freckle-removing essence is 0.15-0.2%;
the glycyrrhiza glabra root extract, the polygonum cuspidatum root extract, the scutellaria baicalensis root extract, the centella asiatica root extract, the flower and/or leaf and/or stem extract of rosemary, and the chamomile flower and/or leaf and/or stem extract are respectively 0.1-0.12% by mass in the whitening and freckle removing essence;
the weight percentage of the wild soybean seed extract is 0.4-0.5%.
8. The essence for whitening and removing freckles according to any one of claims 1 to 4, which is characterized in that:
the preservative comprises caprylyl hydroximic acid, ethylhexyl glycerol, 1, 2-hexanediol and propylene glycol;
the mass percentage of the caprylyl hydroximic acid in the whitening and freckle-removing essence is 0.24-0.25%;
the mass percentage of the ethylhexyl glycerin in the whitening and freckle-removing essence is 0.25-0.3%;
the mass percentage of the 1, 2-hexanediol in the whitening and freckle-removing essence is 0.03-0.05%;
the mass percentage of the propylene glycol in the whitening and freckle-removing essence is 0.03-0.05%.
9. The preparation method of the whitening and freckle-removing essence is characterized by comprising the following steps:
the method comprises the following steps: respectively preparing raw materials of a phase A, a phase B and a phase C; the phase A raw materials comprise first part of water, glycerol, nicotinamide, oat peptide, xanthan gum, EDTA disodium and sodium hyaluronate, and are uniformly dispersed at the temperature of more than or equal to 75 ℃; the raw materials of the phase B comprise butanediol and 4-butyl resorcinol, and the raw materials of the phase B are uniformly dispersed at the temperature of less than or equal to 45 ℃; the raw material of phase C comprises a second portion of water, tea extract, glycyrrhiza glabra root extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, centella asiatica root extract, rosemary flower and/or leaf and/or stem extract, chamomile flower and/or leaf and/or stem extract, glycine max seed extract, beta-glucan, 1-methylhydantoin-2-imide, arginine ferulate, caprylhydroxamic acid, ethylhexylglycerin, 1, 2-hexanediol, and propylene glycol; relative to the total mass of the raw materials, the mass percentages of the raw materials are as follows: 1% of 4-butyl resorcinol; 0.5-1% of acetylcysteine; 0.2-0.5% of arginine ferulate; 0.2-0.3% of 1-methylhydantoin-2-imide; 2% of nicotinamide; 0.1% of EDTA disodium; 0.1-0.2% of xanthan gum; 2.5-3% of butanediol; 2.5-3% of glycerol; 2-2.5% of beta-glucan; 2-2.5% of oat peptide; 0.06-0.08% of sodium hyaluronate; 0.15-0.2% of tea extract; 0.1-0.12% of glycyrrhiza glabra root extract; 0.1-0.12% of giant knotweed root extract; 0.1-0.12% of scutellaria root extract; 0.1-0.12% of centella asiatica root extract; 0.1-0.12% of flower and/or leaf and/or stem extract of rosemary; 0.1-0.12% of an extract of chamomile flowers and/or leaves and/or stems; 0.4-0.5% of a wild soybean seed extract; 0.24-0.25% of caprylyl hydroximic acid; 0.25 to 0.3% of ethylhexyl glycerin; 0.03-0.05% of 1, 2-hexanediol; 0.03-0.05% of propylene glycol; the balance of water;
step two: cooling the phase A raw material to 40-45 ℃, adding the phase B raw material and the phase C raw material, and uniformly stirring and dispersing to obtain a mixture;
step three: and cooling the mixture to 35-38 ℃, discharging, standing, and then canning.
10. The method of claim 9, wherein:
in the first step, after the raw material of the phase A is uniformly dispersed at the temperature of more than or equal to 75 ℃, the raw material of the phase A is put into a vacuum stirrer, stirred for more than 5 minutes under the vacuum condition and kept stand at constant temperature;
in the first step, the mass ratio of the first part of water to the second part of water is (25-30): 1;
in the first step, when the raw material of the phase C is dispersed, the second part of water, the tea extract, the glycyrrhiza glabra root extract, the polygonum cuspidatum root extract, the scutellaria baicalensis root extract, the centella asiatica root extract, the rosemary flower and/or leaf and/or stem extract, the chamomile flower and/or leaf and/or stem extract are uniformly mixed, the 1-methylhydantoin-2-imide and the arginine ferulate are uniformly mixed, the caprylhydroxamic acid, the ethylhexyl glycerol, the 1, 2-hexanediol and the propylene glycol are uniformly mixed, and then the obtained three mixtures are mixed with the other raw material of the phase C.
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| CN113081903A (en) * | 2021-04-20 | 2021-07-09 | 东晟源研究院(广州)有限公司 | Transparent whitening essence containing 4-butylresorcinol and preparation method thereof |
| CN113304080A (en) * | 2021-06-07 | 2021-08-27 | 广州黛莱美化妆品有限公司 | Skin color brightening mask and preparation method thereof |
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