CN112120947A - Freckle-removing and whitening composition and application thereof - Google Patents
Freckle-removing and whitening composition and application thereof Download PDFInfo
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- CN112120947A CN112120947A CN202011128353.1A CN202011128353A CN112120947A CN 112120947 A CN112120947 A CN 112120947A CN 202011128353 A CN202011128353 A CN 202011128353A CN 112120947 A CN112120947 A CN 112120947A
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- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 230000002087 whitening effect Effects 0.000 title claims abstract description 19
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 17
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 31
- 239000006071 cream Substances 0.000 claims abstract description 27
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 27
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 4
- 239000011259 mixed solution Substances 0.000 claims description 15
- 239000002562 thickening agent Substances 0.000 claims description 15
- 239000003755 preservative agent Substances 0.000 claims description 13
- 239000003963 antioxidant agent Substances 0.000 claims description 12
- 239000002738 chelating agent Substances 0.000 claims description 12
- 230000002335 preservative effect Effects 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 230000003078 antioxidant effect Effects 0.000 claims description 11
- 239000003906 humectant Substances 0.000 claims description 11
- 239000004519 grease Substances 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 8
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 8
- 229920000058 polyacrylate Polymers 0.000 claims description 8
- 229940104261 taurate Drugs 0.000 claims description 8
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 2
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 2
- 235000019486 Sunflower oil Nutrition 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- 229960003993 chlorphenesin Drugs 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 229940070765 laurate Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 239000000467 phytic acid Substances 0.000 claims description 2
- 229940068041 phytic acid Drugs 0.000 claims description 2
- 235000002949 phytic acid Nutrition 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 229940001482 sodium sulfite Drugs 0.000 claims description 2
- 235000010265 sodium sulphite Nutrition 0.000 claims description 2
- 239000001384 succinic acid Substances 0.000 claims description 2
- 239000002600 sunflower oil Substances 0.000 claims description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- 229960001295 tocopherol Drugs 0.000 claims description 2
- 229930003799 tocopherol Natural products 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 24
- 230000003266 anti-allergic effect Effects 0.000 abstract description 4
- 239000000047 product Substances 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 10
- 239000000839 emulsion Substances 0.000 description 5
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 229940098760 steareth-2 Drugs 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 206010040914 Skin reaction Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- JOZMGUQZTOWLAS-UHFFFAOYSA-N 5-butylbenzene-1,3-diol Chemical compound CCCCC1=CC(O)=CC(O)=C1 JOZMGUQZTOWLAS-UHFFFAOYSA-N 0.000 description 1
- 239000004976 Lyotropic liquid crystal Substances 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- -1 alkyl glycosides Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a freckle removing and whitening composition, and relates to the field of skin care. The freckle removing and whitening composition comprises the following components in parts by weight: 0.1-3 parts of butyl resorcinol and 0.5-3 parts of liquid crystal emulsifier, wherein the liquid crystal emulsifier is a polyglycerol derivative. In addition, the invention also provides a cream product which has no oil-out layering phenomenon and has good spot pasting result under the condition of not adding soothing and anti-allergy components through 90-day high-temperature accelerated test at 48 ℃.
Description
Technical Field
The invention relates to the field of skin care, in particular to a freckle-removing and whitening composition and application thereof.
Background
Butyl resorcinol is an n-butyl modified derivative of resorcinol, has a strong tyrosinase inhibition effect, is a very effective freckle removing and whitening agent, and has application difficulties of easy discoloration, high irritation, easy demulsification of a cream system and the like.
Because of the above difficulties, the cream products on the market, which are generally butyl resorcinol coated with nano-particles, generally have the disadvantages of low addition of active substances and low cost performance.
Disclosure of Invention
Based on the above, the invention aims to overcome the defects of the prior art and provide the freckle removing and whitening composition which still has good freckle pasting result under the condition of not adding soothing and anti-allergy components.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the freckle-removing and whitening composition comprises the following components in parts by weight: 0.1-3 parts of butyl resorcinol and 0.5-3 parts of liquid crystal emulsifier, wherein the liquid crystal emulsifier is a polyglycerol derivative.
The freckle-removing and whitening composition with high content of butyl resorcinol and good stability is obtained by using the liquid crystal emulsifier with relatively low content, and still has good freckle pasting result under the condition of not adding soothing and anti-allergy components.
Preferably, the freckle removing and whitening composition comprises the following components in parts by weight: 0.4-2 parts of butyl resorcinol and 0.5-2 parts of liquid crystal emulsifier, wherein the liquid crystal emulsifier is at least one of polyglycerol-10 stearate, polyglycerol-2 stearate and polyglycerol-10 laurate.
More preferably, the freckle removing and whitening composition comprises the following components in parts by weight: 0.5 part of butyl resorcinol and 0.5 part of liquid crystal emulsifier, wherein the liquid crystal emulsifier is polyglycerol-2 stearate.
In addition, the invention also provides application of the freckle removing and whitening composition in cosmetics.
Meanwhile, the invention also provides a cream skin care product containing the freckle removing and whitening composition.
Preferably, the cream skin care product comprises the following components in parts by weight: 0.1-3 parts of butyl resorcinol, 0.5-3 parts of liquid crystal emulsifier, 4-20 parts of grease, 1-20 parts of humectant, 0.2-3 parts of thickener, 0.01-0.1 part of chelating agent, 0.01-3 parts of pH regulator, 0.01-0.2 part of antioxidant and 0.01-2 parts of preservative.
The liquid crystal refers to a lyotropic liquid crystal generated along with the increase of the concentration of a surfactant in water, and in a cream system, a surfactant bilayer is formed around emulsion droplets by a liquid crystal structure, so that the agglomeration of the emulsion droplets can be reduced, and the phenomena of emulsion breaking by layering of cream and the like are reduced. Generally, an emulsifier which easily forms liquid crystal is called a liquid crystal emulsifier, and mainly includes alkyl glycosides, polyglycerol derivatives, lecithin, sucrose derivatives, phosphate derivatives, and the like.
Preferably, the cream skin care product comprises the following components in parts by weight: 0.4-2 parts of butyl resorcinol, 0.5-2 parts of liquid crystal emulsifier, 4-15 parts of grease, 5-15 parts of humectant, 1-2 parts of thickener, 0.01-0.1 part of chelating agent, 0.01-0.05 part of pH regulator, 0.05-0.15 part of antioxidant and 0.1-1 part of preservative.
Preferably, the cream skin care product comprises the following components in parts by weight: 0.5 part of butyl resorcinol, 0.5 part of liquid crystal emulsifier, 8 parts of grease, 10 parts of humectant, 1.5 parts of thickener, 0.05 part of chelating agent, 0.03 part of pH regulator, 0.1 part of antioxidant and 0.5 part of preservative.
Preferably, the cream skin care product is at least one of the following (a) to (g):
(a) the oil is at least one of caprylic/capric triglyceride, cetostearyl alcohol, sunflower oil and mineral oil;
(b) the humectant is at least one of glycerol, butanediol and dipropylene glycol;
(c) the chelating agent is at least one of EDTA disodium, sodium citrate and phytic acid;
(d) the pH regulator is at least one of citric acid, succinic acid and lactic acid;
(e) the antioxidant is at least one of tocopherol, sodium sulfite and butylated hydroxytoluene;
(f) the preservative is at least one of chlorphenesin, phenoxyethanol, methylparaben, p-hydroxyacetophenone and hexanediol;
(g) the thickening agent is a compound of polyacrylate cross-linked polymer-6, acryloyl dimethyl ammonium taurate/VP copolymer and polyacrylate-13;
wherein, the weight ratio of the polyacrylate crosslinked polymer-6 to the acryloyl dimethyl ammonium taurate/VP copolymer to the polyacrylate-13 is as follows: polyacrylate crosslinked polymer-6: acryloyldimethyl ammonium taurate/VP copolymer: polyacrylate-13 ═ (2-4): (3-5): (7-9);
the weight ratio of the polyacrylate crosslinked polymer-6 to the acryloyl dimethyl ammonium taurate/VP copolymer to the polyacrylate-13 is as follows: polyacrylate crosslinked polymer-6: acryloyldimethyl ammonium taurate/VP copolymer: polyacrylate-13 ═ 3: 4: 8.
the thickener can reduce the collision contact among emulsion droplets and reduce the possibility of merging and demulsifying the emulsion droplets through the suspension capacity of the thickener.
According to the invention, the content of the liquid crystal emulsifier is further reduced by compounding the thickener, the main stimulus sources in the cosmetics are preservatives, essence, emulsifier and the like, and the reduction of the content of the emulsifier is beneficial to the reduction of potential stimulus sources.
In addition, the invention also provides a preparation method of the cream skin care product, which comprises the following steps:
(1) adding a thickening agent, a preservative, a chelating agent, a pH regulator, a humectant and water into an emulsifying pot, heating to 75-85 ℃, homogenizing and stirring to obtain a mixed solution A;
(2) adding butyl resorcinol, grease and an emulsifier into an oil phase pot, heating to 75-85 ℃, homogenizing and stirring for 3-8min to obtain a mixed solution B;
(3) homogenizing and stirring the mixed solution A obtained in the step (1) and the mixed solution B obtained in the step (2) to obtain a mixed solution C;
(4) and (3) cooling the mixed liquid C obtained in the step (2) to 40-50 ℃, adding an antioxidant, and uniformly stirring to obtain the cream skin care product.
Compared with the prior art, the invention has the beneficial effects that: the freckle-removing and whitening composition provided by the invention has stronger high-temperature stability, is applied to a cream product, has no oil-out layering phenomenon after 90-day high-temperature accelerated test at 48 ℃, and has better patch results under the condition of not adding a soothing and anti-allergy component.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1-5 are provided herein, and the components and parts by weight of the specific examples 1-5 are selected as shown in tables 1 and 2:
TABLE 1 selection of compositions and parts by weight of examples 1-5
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Butyl resorcinol | 0.1 | 3 | 0.4 | 2 | 0.5 |
| Liquid crystal emulsifier | 0.5 | 3 | 0.5 | 2 | 0.5 |
| Oil and fat | 4 | 20 | 4 | 15 | 8 |
| Moisture-retaining agent | 1 | 20 | 5 | 15 | 10 |
| Thickening agent | 0.2 | 3 | 1 | 2 | 1.5 |
| Chelating agents | 0.01 | 0.1 | 0.01 | 0.1 | 0.05 |
| pH regulator | 0.01 | 3 | 0.01 | 0.05 | 0.03 |
| Antioxidant agent | 0.01 | 0.2 | 0.05 | 0.15 | 0.1 |
| Preservative | 0.01 | 2 | 0.1 | 1 | 0.5 |
TABLE 2 selection of compositions and parts by weight of examples 1-5
Examples 1-5 the cream skin care products described in the examples were prepared by weighing the components in the parts by weight shown in tables 1 and 2 as follows:
(1) adding a thickening agent, a preservative, a chelating agent, a pH regulator, a humectant and water into an emulsifying pot, heating to 75-85 ℃, homogenizing and stirring to obtain a mixed solution A;
(2) adding butyl resorcinol, grease and an emulsifier into an oil phase pot, heating to 75-85 ℃, homogenizing and stirring for 3-8min to obtain a mixed solution B;
(3) homogenizing and stirring the mixed solution A obtained in the step (1) and the mixed solution B obtained in the step (2) to obtain a mixed solution C;
(4) and (3) cooling the mixed liquid C obtained in the step (2) to 40-50 ℃, adding an antioxidant, and uniformly stirring to obtain the cream skin care product.
Meanwhile, the application is provided with a comparative example, in the comparative example 1, the emulsifier adopts steareth-2 and steareth-2, wherein the weight part of the steareth-2 is 2 parts, the weight part of the steareth-2 is 3 parts, and the selection and preparation methods of the rest components and the weight parts are completely the same as those of the example 5; comparative example 2 is a prior art product, using nano-encapsulated butyl resorcinol.
Test example 1 stability test
The test process comprises the following steps: and (3) performing high-temperature 48 ℃ (constant-temperature drying box) and low-temperature-18 ℃ (refrigerator) tests on the sample, performing UV illumination (standard light source lamp box) and circulation at-18 ℃ -48 ℃ (high-low temperature alternating box) tests, and observing whether the state of the sample is abnormal or not after the tests are continued for 90 days.
And (3) test results: the stability test results are shown in table 3:
table 3 stability test results
As can be seen from Table 3, the cream products provided by the embodiment of the invention have good stability, and have no abnormality in tests of high temperature 48 ℃ (constant temperature drying box), low temperature-18 ℃ (refrigerator) and circulation at-18 ℃ -48 ℃ (high-low temperature alternating box) which last for 90 days; comparative example 1 was irradiated at a high temperature of 48 ℃ and delamination occurred on the third day, and was irradiated at a temperature of-18 ℃ to 48 ℃ in a cyclic manner and delaminated on the seventh day. Comparative example 2 was irradiated at a high temperature of 48 c and turned slightly yellow on the seventh day, and thus, the cream product provided by the example of the present invention had far better stability than the comparative example.
Test example 2 Patch test
The test substance: cosmetic end product base
Negative control: blank control
Subject: in total, 30 persons, 8 persons in male, 22 persons in female, age 22 to 35 years, average age 28 ± 1 year, according to the subject's volunteer enrollment criteria.
The spot pasting test method comprises the following steps: selecting qualified spot test equipment, placing 0.020g-0.025g (solid) or 0.020mL-0.025mL (liquid) of a test object in a spot tester by a closed spot test method, externally applying a hypoallergenic adhesive tape to the arm of a test object, removing the test object after 24 hours, observing skin reactions after 0.5 hour, 24 hours and 48 hours after removal respectively, and recording the result according to the skin reaction grading standard in the current effective technical specification.
Spot test standard:
TABLE 4 Patch test standards
And (3) test results: the patch test results are shown in table 5:
TABLE 5 Patch test results
As can be seen from table 5, the patch test result in example 5 shows that 30 persons all have negative reactions, only 1 person in examples 3 and 4 has suspicious reactions after 0.5 hour, and only 2 persons in examples 1 and 2 have suspicious reactions after 0.5 hour, but the follow-up results are negative, so that the cream product provided by the invention has extremely low irritation; in comparative example 1 it is shown that there are 22 people who tested weak erythema after 0.5 hours and still weak erythema after 48 hours, indicating that the cream product of comparative example 1 is irritating. In comparative example 2 it was shown that 3 of the test showed weak erythema after 0.5 hours and 2 of the test still showed weak erythema after 24 hours, indicating that the cream product in comparative example 2 was slightly less irritating than the example.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The freckle-removing and whitening composition is characterized by comprising the following components in parts by weight: 0.1-3 parts of butyl resorcinol and 0.5-3 parts of liquid crystal emulsifier, wherein the liquid crystal emulsifier is a polyglycerol derivative.
2. The spot removing and whitening composition according to claim 1, comprising the following components in parts by weight: 0.4-2 parts of butyl resorcinol and 0.5-2 parts of liquid crystal emulsifier, wherein the liquid crystal emulsifier is at least one of polyglycerol-10 stearate, polyglycerol-2 stearate and polyglycerol-10 laurate.
3. The spot removing and whitening composition according to claim 2, comprising the following components in parts by weight: 0.5 part of butyl resorcinol and 0.5 part of liquid crystal emulsifier, wherein the liquid crystal emulsifier is polyglycerol-2 stearate.
4. Use of the spot removing and whitening composition according to any one of claims 1 to 3 in cosmetics.
5. A cream skin care product comprising the spot-removing whitening composition according to any one of claims 1 to 3.
6. The cream skin care product of claim 5, comprising the following components in parts by weight: 0.1-3 parts of butyl resorcinol, 0.5-3 parts of liquid crystal emulsifier, 4-20 parts of grease, 1-20 parts of humectant, 0.2-3 parts of thickener, 0.01-0.1 part of chelating agent, 0.01-3 parts of pH regulator, 0.01-0.2 part of antioxidant and 0.01-2 parts of preservative.
7. The cream skin care product of claim 6, comprising the following components in parts by weight: 0.4-2 parts of butyl resorcinol, 0.5-2 parts of liquid crystal emulsifier, 4-15 parts of grease, 5-15 parts of humectant, 1-2 parts of thickener, 0.01-0.1 part of chelating agent, 0.01-0.05 part of pH regulator, 0.05-0.15 part of antioxidant and 0.1-1 part of preservative.
8. The cream skin care product of claim 7, comprising the following components in parts by weight: 0.5 part of butyl resorcinol, 0.5 part of liquid crystal emulsifier, 8 parts of grease, 10 parts of humectant, 1.5 parts of thickener, 0.05 part of chelating agent, 0.03 part of pH regulator, 0.1 part of antioxidant and 0.5 part of preservative.
9. The cream skin care product according to any one of claims 6 to 8, characterized by at least one of the following (a) to (g):
(a) the oil is at least one of caprylic/capric triglyceride, cetostearyl alcohol, sunflower oil and mineral oil;
(b) the humectant is at least one of glycerol, butanediol and dipropylene glycol;
(c) the chelating agent is at least one of EDTA disodium, sodium citrate and phytic acid;
(d) the pH regulator is at least one of citric acid, succinic acid and lactic acid;
(e) the antioxidant is at least one of tocopherol, sodium sulfite and butylated hydroxytoluene;
(f) the preservative is at least one of chlorphenesin, phenoxyethanol, methylparaben, p-hydroxyacetophenone and hexanediol;
(g) the thickening agent is a compound of polyacrylate cross-linked polymer-6, acryloyl dimethyl ammonium taurate/VP copolymer and polyacrylate-13;
wherein, the weight ratio of the polyacrylate crosslinked polymer-6 to the acryloyl dimethyl ammonium taurate/VP copolymer to the polyacrylate-13 is as follows: polyacrylate crosslinked polymer-6: acryloyldimethyl ammonium taurate/VP copolymer: polyacrylate-13 ═ (2-4): (3-5): (7-9).
10. A method of preparing a cream skin care product according to any one of claims 6 to 9, comprising the steps of:
(1) adding a thickening agent, a preservative, a chelating agent, a pH regulator, a humectant and water into an emulsifying pot, heating to 75-85 ℃, homogenizing and stirring to obtain a mixed solution A;
(2) adding butyl resorcinol, grease and an emulsifier into an oil phase pot, heating to 75-85 ℃, homogenizing and stirring for 3-8min to obtain a mixed solution B;
(3) homogenizing and stirring the mixed solution A obtained in the step (1) and the mixed solution B obtained in the step (2) to obtain a mixed solution C;
(4) and (3) cooling the mixed liquid C obtained in the step (2) to 40-50 ℃, adding an antioxidant, and uniformly stirring to obtain the cream skin care product.
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| CN112587426A (en) * | 2021-01-07 | 2021-04-02 | 广州玖睿生物科技有限公司 | Whitening and freckle removing essence and preparation method thereof |
| CN112603869A (en) * | 2021-01-07 | 2021-04-06 | 广州玖睿生物科技有限公司 | Whitening spot-lightening cream and preparation method thereof |
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| CN112587426A (en) * | 2021-01-07 | 2021-04-02 | 广州玖睿生物科技有限公司 | Whitening and freckle removing essence and preparation method thereof |
| CN112603869A (en) * | 2021-01-07 | 2021-04-06 | 广州玖睿生物科技有限公司 | Whitening spot-lightening cream and preparation method thereof |
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