CN113181095A - Anti-inflammatory repairing cosmetic composition and application thereof - Google Patents
Anti-inflammatory repairing cosmetic composition and application thereof Download PDFInfo
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- CN113181095A CN113181095A CN202110500753.9A CN202110500753A CN113181095A CN 113181095 A CN113181095 A CN 113181095A CN 202110500753 A CN202110500753 A CN 202110500753A CN 113181095 A CN113181095 A CN 113181095A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses an anti-inflammatory repairing cosmetic composition and application thereof, and relates to the technical field of cosmetics. The anti-inflammatory repairing cosmetic composition comprises the following components in percentage by mass: stearyl glycyrrhetinate: 0.002-0.25%; tetrahydro-methyl-pyrimidine-carboxylic acid: 0.002-2%; centella asiatica leaf extract: 0.002-1.5%; cosmetic adjuvant matrix: 96.25 to 98 percent. The anti-inflammatory repairing cosmetic composition disclosed by the invention can effectively solve the problem of skin inflammation and repair skin aging symptoms caused by inflammation by utilizing the synergistic effect of stearyl glycyrrhetinate, tetrahydro-methylpyrimidine carboxylic acid and centella asiatica leaf extract and inhibiting various effects of leukocyte mediators I L6 and I L8, forming a protective shell around skin cells and skin tissues, inhibiting interleukin I L-1 alpha and the like.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-inflammatory repairing cosmetic composition and application thereof.
Background
The american academy Elias PM proposed the famous skin natural barrier "brick wall theory". That is, in the "brick wall" structure of the skin barrier, keratinocytes are "bricks", the connections between cells are "rebar", and the intercellular lipids are "mortar". The leather-fat film is located at the outermost layer of the brick wall, which can be compared with the paint layer of the outer wall, and the structure forms a natural protective barrier for human skin. The natural skin barrier has moisturizing, anti-inflammatory, and moisture retaining effects. However, the skin is damaged to some extent by factors such as VU radiation, air pollution, improper use of skin care products, and living stress, and the skin barrier is damaged, which is accompanied by various skin problems. Such as skin inflammation, which causes the skin to develop a mass, redness, pain, burning, painful reaction, generally an acute reaction, which is associated with chronic inflammation, such as inflammatory aging, which is a mild, controlled, asymptomatic, chronic and systemic inflammation, which causes significant signs of skin aging, such as wrinkles, loss of elasticity, and the like.
"aging is accompanied by inflammation, which in turn causes aging" through a vicious cycle, ultimately resulting in a chronic, systemic pro-inflammatory state in which tissue damage and repair are present simultaneously. These two mechanisms of antagonism are likely to be key causes of aging and aging-related diseases, and prolonged inflammation and repair results in the accumulation of fine tissue damage. Therefore, the control of inflammation is critical, which facilitates the repair of the skin barrier and improves the skin's ability to resist adverse factors.
In view of the problem of inflammation of the skin, there is a need to develop an anti-inflammatory cosmetic composition.
Disclosure of Invention
In order to solve the technical problems, the invention provides an anti-inflammatory repairing cosmetic composition which can relieve the skin inflammation problem, repair the skin barrier and improve the capability of the skin to resist adverse factors.
The purpose of the invention is realized by the following technical scheme: the anti-inflammatory repairing cosmetic composition comprises the following components in percentage by mass:
stearyl glycyrrhetinate: 0.002-0.25%;
tetrahydro-methyl-pyrimidine-carboxylic acid: 0.002-2%;
centella asiatica leaf extract: 0.002-1.5%;
cosmetic adjuvant matrix: 96.25 to 98 percent.
Further, the cosmetic auxiliary material matrix is selected from one or more of a solvent, a humectant, a thickening agent, an emulsifier, an emollient, a sun-screening agent, an essence and a perfume and a preservative.
Further, the cosmetic auxiliary material matrix consists of the following components in percentage by mass:
solvent: 15 to 95 percent;
humectant: 1 to 15 percent;
thickening agent: 0 to 3 percent;
emulsifier: 0 to 6 percent;
and (3) an emollient: 0 to 20 percent;
sunscreen agents: 0 to 35 percent;
essence and spice: 0 to 2 percent;
preservative: 0.002-5%.
Further, the cosmetic auxiliary material matrix consists of the following components in percentage by mass:
solvent: 20 to 95 percent;
humectant: 5 to 12 percent;
thickening agent: 0.02-1.5%;
emulsifier: 0.01 to 5 percent;
and (3) an emollient: 1 to 10 percent;
sunscreen agents: 0 to 30 percent;
essence and spice: 0.02-0.4%;
preservative: 0.05-3%;
wherein the sunscreen agent is one or more of a physical sunscreen agent or a chemical sunscreen agent.
Further, the humectant is one or more of 1, 3-propylene glycol, glycerol, 1, 2-hexanediol, butanediol, dipropylene glycol, 1, 2-pentanediol, saccharide isomer, trehalose, betaine, sodium hyaluronate, hyaluronic acid, polyethylene glycol-8, glycerol acrylate/acrylate copolymer, and ethylhexylglycerol.
Further, the sunscreen agent is one or more of ethylhexyl methoxycinnamate, octocrylene, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, methylene bis-benzotriazolyl tetramethyl butyl phenol, homosalate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysiloxane-15, butyl methoxydibenzoyl methane, ethylhexyl salicylate, benzophenone-3, benzophenone-4, phenyl dibenzoimidazole tetrasulfonate disodium, zinc oxide and titanium dioxide.
Further, the thickening agent is one or more of xanthan gum, cellulose and modified substances thereof, polyacrylic acid, carbomer, hydroxypropyl starch phosphate, sodium polyacrylate grafted starch, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate/VP copolymer, polyacrylamide, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer and polyacrylate-13.
Further, the emulsifier is one or more of PPG-26-buthanol polyether-26, polysorbates, PEG-40 hydrogenated castor oil, glyceryl stearate, sodium stearyl glutamate, sorbitan fatty acid esters, cetearyl olive oleate, fatty alcohol polyethers, alkyl glucosides, sucrose fatty acid esters, polyethylene glycol stearates, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, polyglycerol fatty acid esters, hydrogenated lecithin, cetearyl alcohol, potassium cetyl phosphate, and polyethylene glycol polysiloxanes.
Further, the emollient is one or more of animal fat, vegetable fat, mineral fat, synthetic fat and synthetic fat composition.
Further, the preservative is one or more of phenoxyethanol, imidazolidinyl urea, parabens and organic acids.
Furthermore, the solvent of the skin care composition with anti-inflammatory repair function is deionized water.
The stearyl glycyrrhetinic acid ester adopted by the invention is a derivative synthetic product of glycyrrhetinic acid which is a natural anti-inflammatory drug, and has better compatibility, better transdermal absorption effect and stronger anti-inflammatory capability compared with glycyrrhetinic acid; the introduction of the stearyl group enables the product to have a certain moisturizing function, and meanwhile, due to the fact that the melting point is reduced, the compatibility is good, the stearyl group can be easily dissolved in various types of lipid and alcohols, so that the product has better skin affinity and transdermal absorption effects, the anti-inflammatory and anti-allergy skin repairing effects are enhanced, and meanwhile, the product also has excellent skin whitening and sun-screening assisting effects.
The adopted tetrahydro-methyl pyrimidine carboxylic acid is a micromolecular amino acid derivative, has the purity of more than 96 percent and is obtained by fermentation through a biotechnology. In the invention, the tetrahydro-methyl pyrimidine carboxylic acid has strong anti-compression protection function, protects Langerhans cells from being damaged by UV light radiation, has full-spectrum protection characteristic, has good anti-inflammatory and anti-allergy effects on skin damage caused by UV radiation, has the action effect superior to that of hydrocortisone, and has no other side effects. Meanwhile, the tetrahydro-methyl pyrimidine carboxylic acid can bind surrounding water molecules to form a complex, and the complex is wrapped around cells, enzymes, proteins and other organic molecules to form a protective shell with the functions of protecting, nourishing and stabilizing hydration, and has the effects of moisturizing, repairing skin barriers, resisting wrinkles, resisting photoaging and the like.
The centella asiatica (CENTELLAASIATICA) leaf extract is extracted from the centella asiatica leaves of Madagasca, has stable quality and highest content of bioactive substances (triterpenes), has the effects of resisting inflammation, aging and saccharification, scavenging free radicals and reducing IL-1αAnti-photoaging, and improving skin elasticity and firmness.
In addition, another object of the present invention is to provide the use of the above anti-inflammatory repair cosmetic composition in cosmetics having anti-inflammatory repair efficacy.
Further, the cosmetic is in the form of skin lotion, skin essence, skin lotion, skin cream, skin gel, sun cream, sun gel or sun spray.
The invention has the beneficial effects that:
the anti-inflammatory repairing cosmetic composition adopts the stearyl glycyrrhetinate, has good skin affinity, can quickly permeate into a skin fiber cell layer, and has good anti-inflammatory effect by inhibiting the rapid inhibition of leukocyte mediators IL6 and IL8, particularly leukocyte mediator IL 8. The tetrahydro-methyl pyrimidine carboxylic acid can not absorb ultraviolet rays and has no filtering effect, but can form a protective shell around skin cells and skin tissues, and the skin is prevented from being damaged by radiation of long-wave ultraviolet rays, medium-wave ultraviolet rays, infrared rays and visible light at a cell level, so that inflammation caused by skin damage due to ultraviolet rays is avoided. The centella asiatica leaf extract is effective in inhibiting inflammation by effectively inhibiting interleukin IL-1 alpha. The components have a synergistic effect when being compounded, so that the problem of skin inflammation can be effectively solved, and the skin aging symptom caused by inflammation can be repaired.
Detailed Description
The technical solution of the present invention will be clearly and completely described below with reference to some embodiments, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the specification of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.
The following percentages (%) are mass percentages unless otherwise specified.
Examples 1 to 3, comparative examples 1 to 3 and blank examples
The cosmetic composition with anti-inflammatory and repairing effects provided by the invention is prepared into essence, and the contents of the raw material components, the components of the comparative examples 1-3 and the blank examples are shown in the following table 1.
Table 1:
the essence, flavor and preservative are conventional additives in the cosmetic technical field, and the amount can be added by those skilled in the art according to the type and content of the essence, flavor and preservative described in the application and according to the design requirement of the product.
The cosmetic composition of table 1 was prepared as a sunscreen cream by a method comprising the steps of:
1. adding deionized water, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, glycerol, methyl ester and butanediol into a water phase pot, stirring and heating to 75-80 ℃, and uniformly stirring and dispersing to obtain phase A;
2. adding octocrylene, ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, diethyl amino oxybenzoyl hexyl benzoate, diisopropyl sebacate, stearyl glycyrrhetinate and dimethyl silylated silica into an oil phase pot, stirring and heating to 75-80 ℃, and stirring and dissolving uniformly to obtain a B phase;
3. pumping A, B into an emulsifying pot at the same time, homogenizing and emulsifying for 6-10 min, stirring for 15-23 min under heat preservation, and cooling water;
4. cooling to 65 deg.C, adding appropriate amount of sterilized water-soluble arginine into emulsifying pot, and stirring;
5. when the temperature of the material body in the emulsifying pot is reduced to below 45 ℃, adding silica, the centella asiatica leaf extract, the tetrahydro-methyl pyrimidine carboxylic acid and the essence/preservative into the emulsifying pot, and uniformly stirring to obtain the sunscreen cream.
Tests prove that the humectant, the sunscreen agent and the thickening agent in the formula of the anti-inflammatory repairing cosmetic composition can also adopt the following components.
The humectant can also be one or more of 1, 3-propylene glycol, 1, 2-hexanediol, dipropylene glycol, 1, 2-pentanediol, saccharide isomer, trehalose, betaine, sodium hyaluronate, hyaluronic acid, polyethylene glycol-8, glycerin acrylate/acrylate copolymer, and ethylhexyl glycerin.
The sunscreen agent may also be one or more of ethylhexyl methoxycinnamate, methylene bis-benzotriazolyl tetramethylbutylphenol, homosalate, polysiloxane-15, butyl methoxydibenzoylmethane, ethylhexyl salicylate, benzophenone-3, benzophenone-4, disodium phenyl dibenzoimidazole tetrasulfonate, zinc oxide, and titanium dioxide.
The thickener can also be one or more of xanthan gum, cellulose and modified substances thereof, polyacrylic acid, carbomer, hydroxypropyl starch phosphate, sodium polyacrylate grafted starch, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate/VP copolymer, polyacrylamide, sodium acrylate/sodium acryloyldimethyl taurate copolymer and polyacrylate-13.
Effect verification test:
(I) Mild testing
The human skin closed patch test was performed according to the human skin patch test specified in the technical standards for cosmetic safety (2015 edition).
1. The test purpose is as follows: and detecting the potential possibility of the test object causing the adverse reaction of the human skin.
2. And (3) test design: the patch tester with the test substance is applied to the skin of the back of the subject for 24 hours. When the test substance is a cosmetic product, the control well is a blank control (containing no substance), and when the test substance is a diluted cosmetic, the diluent of the cosmetic is used in the control well. And respectively grading the skin according to the skin reaction grading standard of the skin closed patch test 30min (after the indentation disappears), 24h and 48h after the test object patch tester is removed.
3. Test samples: the products of examples 1 to 3 and comparative examples 1 to 3 were used as test samples.
4. Test instruments/materials: an analytical balance, a 1mm plaque tester, a medical adhesive tape, a sterilized cotton swab and a 1ml syringe;
5. the test method comprises the following steps:
the volunteer requires: selecting a volunteer with the age of 18-60 and meeting the test requirements as a subject, 30 persons;
the testing steps are as follows: the selected area is not more than 50mm2And qualified spot test equipment with the depth of about 1 mm. The test substance is put into a small chamber of a spot tester, and the dosage is about 0.020g to 0.025 g. Control wells are blank. The spot test device with the tested object is applied to the back of the tested object by using a low-sensitivity adhesive tape, and is lightly pressed by hands to be uniformly applied to the skin for 24 hours.
The skin reactions were observed according to the standard of table 2 30min (after disappearance of the indentation), 24h and 48h after removal of the test article plaque test device, respectively, and the observation results were recorded.
Table 2: skin reaction grading standard of skin closed patch test
6. And (3) analyzing an experimental result: the test results are shown in table 3.
Table 3: test results of human skin closed patch
7. And (4) conclusion: the result of the human skin closed patch test shows that 0 of 30 people has positive reaction.
As can be seen from the above-mentioned human skin closed patch test, the cosmetic compositions with anti-inflammatory repair effects of examples 1 to 3 of the present invention do not cause adverse skin reactions, are very mild, and do not irritate human skin.
(II) anti-inflammatory repair test
1. The instrument comprises the following steps: VISIA CR facial image analysis System (Canfield Scientific).
2. Sample preparation: the products of examples 1 to 3 and comparative examples 1 to 3 were used as test samples;
3. the method comprises the following steps: the subjects were randomly divided into 7 groups of 10 subjects, each group was half-face tested in comparative examples 1-3, respectively, example 1, blank example 1, and example 3, respectively, i.e., half-face tested in comparative examples 1 and 3, i.e., the left and right faces were each treated with a comparative test sample, once in the morning and once in the evening. Before the product is used, a VISIA CR is used for shooting a front high-resolution picture, a probe of a percutaneous water loss determinator is placed at a horizontal position of skin in a test area, a corresponding numerical value is read, after the product is continuously used for 7 days, the VISIA CR is used for shooting the front high-resolution picture, the probe of the percutaneous water loss determinator is used for reading the corresponding numerical value, IPP software is used for comparing and analyzing the inflammation condition of facial erythema before and after use, and the percutaneous water loss rate is calculated.
4. And (3) testing results:
a. the half face erythema inflammation effect of the application example 1 is obviously improved, and the improvement effect is better than that of the comparative examples 1-3 and the blank example; the half face skin water loss of the use example 1 is reduced by 8.1 percent compared with that before use, and the reduction of the half face skin water loss of the use example 1 to the half face skin water loss of the use example 1 is minimum compared with that of the control examples 1-3 and the blank example; the lower the rate of transepidermal water loss, indicating that the skin has a greater water retention capacity and a better barrier function after the composition of example 1 is used.
b. The improvement effect of the inflammation of the half face erythema by using the composition of example 1 is better than that of example 3, and the percutaneous water loss is reduced by 4.6 percent compared with that of example 3, which shows that the composition of example 1 has better repair effect on the skin barrier.
c. The condition of inflammation of half face erythema and the change of the percutaneous water loss rate before and after using the blank case are not large, which shows that the skin inflammation and the skin barrier are hardly improved.
From the above results, it is understood that the cosmetic composition with anti-inflammatory repair of the present invention has a relatively significant anti-inflammatory repair effect through a synergistic effect between components, and the effect is more significant than that of a single anti-inflammatory repair component. Meanwhile, each anti-inflammatory repairing component is added within a reasonable adding amount range, the content of each component is properly improved, and the overall anti-inflammatory repairing effect is more excellent.
It can be understood that, in the range of the mixture ratio disclosed by the present invention, the cosmetics in other formulations have the same effect as that demonstrated in the embodiment, are mild and non-irritant to human skin, and can have good anti-inflammatory repair efficacy.
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
While the invention has been described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. An anti-inflammatory repairing cosmetic composition is characterized by comprising the following components in percentage by mass:
stearyl glycyrrhetinate: 0.002-0.25%;
tetrahydro-methyl-pyrimidine-carboxylic acid: 0.002-2%;
centella asiatica leaf extract: 0.002-1.5%;
cosmetic adjuvant matrix: 96.25 to 98 percent.
2. An anti-inflammatory repairing cosmetic composition according to claim 1 wherein said cosmetic adjunct base is selected from one or more of solvents, humectants, thickeners, emulsifiers, emollients, sunscreens, fragrances and preservatives.
3. An anti-inflammatory repairing cosmetic composition according to claim 2 wherein said cosmetic adjuvant matrix is composed of the following components in mass percent:
solvent: 15 to 95 percent;
humectant: 1 to 15 percent;
thickening agent: 0 to 3 percent;
emulsifier: 0 to 6 percent;
and (3) an emollient: 0 to 20 percent;
sunscreen agents: 0 to 35 percent;
essence and spice: 0 to 2 percent;
preservative: 0.002-5%.
4. An anti-inflammatory repairing cosmetic composition according to claim 3 wherein said cosmetic adjuvant matrix is composed of the following components in mass percent:
solvent: 20 to 95 percent;
humectant: 5 to 12 percent;
thickening agent: 0.02-1.5%;
emulsifier: 0.01 to 5 percent;
and (3) an emollient: 1 to 10 percent;
sunscreen agents: 0 to 30 percent;
essence and spice: 0.02-0.4%;
preservative: 0.05-3%;
wherein the sunscreen agent is one or more of a physical sunscreen agent or a chemical sunscreen agent.
5. An anti-inflammatory make-up cosmetic composition according to any of claims 2 to 4 wherein the humectant is one or more of 1, 3-propanediol, glycerin, 1, 2-hexanediol, butanediol, dipropylene glycol, 1, 2-pentanediol, saccharide isomerate, trehalose, betaine, sodium hyaluronate, hyaluronic acid, polyethylene glycol-8, glycerol acrylate/acrylate copolymer, ethylhexylglycerin.
6. An anti-inflammatory, repairing cosmetic composition according to any of claims 2-4 wherein said sunscreen agent is one or more of ethylhexyl methoxycinnamate, octocrylene, ethylhexyl triazone, hexyl diethylaminobenzoyl benzoate, methylene bis-benzotriazolyl tetramethylbutylphenol, homosalate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysiloxane-15, butyl methoxydibenzoylmethane, ethylhexyl salicylate, benzophenone-3, benzophenone-4, disodium phenyldibenzoimidazole tetrasulfonate, zinc oxide, titanium dioxide.
7. An anti-inflammatory make-up cosmetic composition according to any of claims 2 to 4 wherein the thickener is one or more of xanthan gum, cellulose and its modifications, polyacrylic acid, carbomer, hydroxypropyl starch phosphate, sodium polyacrylate grafted starch, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate/VP copolymer, polyacrylamide, acrylic acid (esters)/C10-30 alkanol acrylate crosspolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate-13.
8. An anti-inflammatory make-up cosmetic composition according to any of claims 2 to 4 wherein the emulsifier is one or more of PPG-26-Butanethoether-26, polysorbates, PEG-40 hydrogenated castor oil, glyceryl stearate, sodium stearyl glutamate, sorbitan fatty acid esters, cetearyl olivate, fatty alcohol polyethers, alkyl glucosides, sucrose fatty acid esters, polyethylene glycol stearates, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, polyglycerol fatty acid esters, hydrogenated lecithin, cetearyl alcohol, potassium cetyl phosphate, polyethylene glycol polysiloxanes.
9. An anti-inflammatory make-up cosmetic composition according to any one of claims 2 to 4 wherein the emollient is one or more of animal fats and oils, vegetable fats and oils, mineral fats and oils, synthetic fat and oil compositions.
10. Use of an anti-inflammatory repair cosmetic composition according to any of claims 1 to 9 in cosmetics, characterized in that the cosmetics have an anti-inflammatory repair efficacy; the cosmetic is in the form of skin lotion, skin essence, skin lotion, skin cream, skin gel, sun cream, sun gel or sun spray.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113693985A (en) * | 2021-09-10 | 2021-11-26 | 河南董欣生物科技有限公司 | Anti-inflammatory skin care composition, preparation method and application |
| CN113797141A (en) * | 2021-09-29 | 2021-12-17 | 广州深叶生物科技有限公司 | Acne-removing composition and preparation method and application thereof |
| CN115300432A (en) * | 2022-09-05 | 2022-11-08 | 广州市涵美化妆品有限公司 | After-sun repair composition and preparation method and application thereof |
| CN115317427A (en) * | 2022-09-13 | 2022-11-11 | 广州市涵美化妆品有限公司 | Anti-inflammatory repairing composition and preparation method and application thereof |
| CN115350130A (en) * | 2022-09-22 | 2022-11-18 | 欧诗漫生物股份有限公司 | Cosmetic composition with instant relieving effect, cosmetic and preparation method thereof |
| CN115487112A (en) * | 2022-09-26 | 2022-12-20 | 上海臻臣化妆品有限公司 | Anti-inflammatory soothing composition for skin |
| WO2023204652A1 (en) * | 2022-04-21 | 2023-10-26 | 주식회사 에스피에스 | Oil-in-water liquid crystal emulsion mist base composition |
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| CN113693985A (en) * | 2021-09-10 | 2021-11-26 | 河南董欣生物科技有限公司 | Anti-inflammatory skin care composition, preparation method and application |
| CN113797141A (en) * | 2021-09-29 | 2021-12-17 | 广州深叶生物科技有限公司 | Acne-removing composition and preparation method and application thereof |
| WO2023204652A1 (en) * | 2022-04-21 | 2023-10-26 | 주식회사 에스피에스 | Oil-in-water liquid crystal emulsion mist base composition |
| CN115300432A (en) * | 2022-09-05 | 2022-11-08 | 广州市涵美化妆品有限公司 | After-sun repair composition and preparation method and application thereof |
| CN115317427A (en) * | 2022-09-13 | 2022-11-11 | 广州市涵美化妆品有限公司 | Anti-inflammatory repairing composition and preparation method and application thereof |
| CN115350130A (en) * | 2022-09-22 | 2022-11-18 | 欧诗漫生物股份有限公司 | Cosmetic composition with instant relieving effect, cosmetic and preparation method thereof |
| CN115487112A (en) * | 2022-09-26 | 2022-12-20 | 上海臻臣化妆品有限公司 | Anti-inflammatory soothing composition for skin |
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