CN111956519A - Small nucleic acid skin care product capable of quickly and safely removing freckles - Google Patents
Small nucleic acid skin care product capable of quickly and safely removing freckles Download PDFInfo
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- CN111956519A CN111956519A CN202010689579.2A CN202010689579A CN111956519A CN 111956519 A CN111956519 A CN 111956519A CN 202010689579 A CN202010689579 A CN 202010689579A CN 111956519 A CN111956519 A CN 111956519A
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- nucleic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention relates to a skin care product for rapidly and safely removing freckles by using small nucleic acid, which is characterized by comprising 0.001-0.03% of small nucleic acid active ingredient and 99.97-99.999% of cosmetic auxiliary material in percentage by mass. The skin care product for whitening and removing freckles provided by the invention can effectively inhibit the formation of melanin, has the functions of moisturizing and whitening skin and the function of stimulating skin metabolism, and achieves the effects of comprehensively conditioning, whitening and removing freckles.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a skin care product capable of quickly and safely removing freckles by using small nucleic acid.
Background
Whitening has long been a goal sought by women and there are many whitening products on the market today. The earliest whitening methods were peeling and bleaching with alcohol, acid, etc., but they are dangerous and unsuitable for formulation of cosmetics for long-term use. At present, people know that the difference of dark and light skin colors is closely related to the content of melanin in skin along with the deepening understanding of the public on whitening. Melanin is a protein present in the basal layer of the skin of everyone. The irradiation of ultraviolet rays can change melanin to generate a substance for protecting skin, and then the melanin moves layer by layer through cell metabolism to reach the epidermis layer of the skin, so that the skin problems of color spots, uneven skin color and the like seen by people are formed. The synthesis of melanin requires the participation of neuraminidase, so that whitening products containing various neuraminidase inhibitors are continuously available. Commonly used inhibitors of neuraminidase are kojic acid, arbutin and some herbal extracts, however, these substances are not very effective in whitening products. With the continuous research of researchers, a new whitening idea appears, and small nucleic acid, namely siRNA is utilized to generate whitening effect. Such whitening effect is relatively much safer. Common genes associated with melanin formation are: neuraminidase (tyr), neuraminidase-related protein (tyrp) and microphthalmia-related transcription factor (mitf). In order to ensure that the small nucleic acid can be absorbed by a human body and has the whitening effect, the invention provides the high-activity small nucleic acid which can effectively remove freckles and keep the white state of the skin besides the whitening function.
Disclosure of Invention
Therefore, the invention provides a rapid and safe spot-removing skin care product containing the small nucleic acid, which comprises 0.001-0.03% of the active ingredient of the small nucleic acid and 99.97-99.999% of cosmetic auxiliary materials in percentage by mass.
Further, the small nucleic acid active ingredients comprise the following components in percentage by weight: MITF-sRNA 30-90%, TYR-sRNA 5-60% and TYRP-sRNA 5-30%.
Further, the small nucleic acid active ingredients comprise the following components in percentage by weight: MITF-sRNA 60%, TYR-sRNA 30%, TYRP-sRNA 10%.
Further, the cosmetic auxiliary materials comprise polyhydrodecacene, sorbitan olivine oleate, stearic acid, cetyl alcohol, base oil, cyclopentadimethylsiloxane, bis-PEG-15 methyl ether polydimethylsiloxane, acryloyl dimethyl ammonium taurate/VP copolymer, shea butter, essence, hydrogenated ethylhexyl olivine oleate, EDTA disodium, lipoic acid, a humectant and water.
Further, the active ingredient of the small nucleic acid is 0.004 percent and the cosmetic auxiliary material is 99.996 percent.
Further, the skin care product comprises the following components in percentage by weight: 0.004% of small nucleic acid active ingredient, 3.5% of polyhydrodecarens, 3% of sorbitan olivate oleate, 1.8% of stearic acid, 2% of cetyl alcohol, 1.2% of base oil, 2% of cyclopentadimethylsiloxane, 5% of bis-PEG-15 methyl ether polydimethylsiloxane, 0.4% of acryloyl dimethyl taurate/VP copolymer, 3% of shea butter fruit resin, 0.15% of essence, 4% of hydrogenated olive oil ethylhexyl oleate, 0.1% of EDTA disodium, 1% of lipoic acid, 5% of humectant and the balance of water.
Further, the base grease is jojoba oil, dimethicone, or mixtures thereof.
Further, the humectant is glycerin, 1, 3-butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol/octaethylene glycol, hyaluronic acid, glyceryl caprylate, or a mixture of two or more thereof.
Further, the balance is deionized water.
Further, the ammonium acryloyldimethyltaurate/VP copolymer can be composed of xanthan gum, or a mixture of xanthan gum and an ammonium acryloyldimethyltaurate/VP copolymer.
Compared with the prior art, the whitening and freckle-removing cream provided by the invention has the beneficial effects that the whitening and freckle-removing cream can efficiently inhibit the formation of melanin, has the effects of moisturizing and moistening skin and stimulating skin metabolism, and achieves the effect of comprehensively conditioning whitening and freckle-removing.
Furthermore, the invention is a high-efficiency penetrant which can help other components to enter skin cells and improve the state of the skin cells, thereby changing the overall state of the skin.
Particularly, the whitening and freckle-removing functional component is safe, and no component is excessively added, so that the whitening and freckle-removing functional component does not have any unsuitable condition and is non-toxic and safe. Moreover, the continuous use of the product of the invention can stimulate the metabolism of the skin, improve the metabolic index and permanently improve the real state of the skin.
Detailed Description
In order that the objects and advantages of the invention will be more clearly understood, the invention is further described below with reference to examples; it should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
For convenience, the terms "double-stranded nucleic acid molecule", "small nucleic acid molecule", "RNA molecule", "double-stranded RNA molecule" or "dsRNA" are used interchangeably hereinafter and are meant to be equivalent in meaning and scope.
The invention provides a skin care product for rapidly and safely removing freckles by using small nucleic acid, which comprises 0.001-0.03% of small nucleic acid active ingredient and 99.97-99.999% of cosmetic auxiliary material in percentage by mass. Particularly, the active ingredients of the small nucleic acid comprise the following components in percentage by weight: MITF-sRNA 30-90%, TYR-sRNA 5-60% and TYRP-sRNA 5-30%. Specifically, in the embodiment of the invention, the small nucleic acid active ingredients comprise the following components in percentage by weight: MITF-sRNA 60%, TYR-sRNA 30%, TYRP-sRNA 10%. The cosmetic auxiliary materials comprise polydecene, sorbitan olivine oleate, stearic acid, cetyl alcohol, base oil, cyclopentadimethylsiloxane, bis-PEG-15 methyl ether polydimethylsiloxane, acryloyl dimethyl ammonium taurate/VP copolymer, shea butter, essence, hydrogenated olive oil ethylhexyl ester, EDTA disodium, lipoic acid, a humectant and water.
Specifically, the skin care product capable of rapidly and safely removing the freckles comprises the following components, wherein the active component of the small nucleic acid is 0.004%, and the cosmetic auxiliary material is 99.996%. The skin care product comprises the following components in percentage by weight: 0.004% of small nucleic acid active ingredient, 3.5% of polyhydrodecarens, 3% of sorbitan olivate oleate, 1.8% of stearic acid, 2% of cetyl alcohol, 1.2% of base oil, 2% of cyclopentadimethylsiloxane, 5% of bis-PEG-15 methyl ether polydimethylsiloxane, 0.4% of acryloyl dimethyl taurate/VP copolymer, 3% of shea butter fruit resin, 0.15% of essence, 4% of hydrogenated olive oil ethylhexyl oleate, 0.1% of EDTA disodium, 1% of lipoic acid, 5% of humectant and the balance of water.
Further, the base grease is jojoba oil, dimethicone, or a mixture thereof. In practical applications, specific raw materials for the base oil and fat can be selected according to practical applications, and the invention is not limited herein, and all that is required is to be implemented specifically.
Specifically, the humectant is glycerin, 1, 3-butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol/octanediol, hyaluronic acid, glyceryl caprylate, or a mixture of two or more thereof. The balance being deionized water. The ammonium acryloyldimethyltaurate/VP copolymer can consist of xanthan gum, or a mixture of xanthan gum and an ammonium acryloyldimethyltaurate/VP copolymer.
Example 1:
a skin care product capable of rapidly and safely removing freckles comprises, by weight, 0.004% of active ingredients of small nucleic acids, 3.5% of polyhydrogenated polydecene, 3% of sorbitan olivate, 1.8% of stearic acid, 2% of cetyl alcohol, 1.2% of base oil, 2% of cyclopenta dimethyl siloxane, 5% of bis-PEG-15 methyl ether dimethyl silicone, 0.4% of acryloyl dimethyl ammonium taurate/VP copolymer, 3% of shea butter, 0.15% of essence, 4% of hydrogenated ethylhexyl olivate, 0.1% of EDTA disodium, 1% of lipoic acid, 5% of moisturizers and the balance of deionized water.
Wherein the active ingredient of the small nucleic acid consists of 30 percent of MITF-sRNA, 60 percent of TYR-sRNA and 10 percent of TYRP-sRNA in percentage by weight;
example 2:
a skin care product capable of rapidly and safely removing freckles comprises, by weight, 0.001% of active ingredient of small nucleic acid, 3% of polyhydrogenated polydecene, 3.5% of sorbitan olivate oleate, 2% of stearic acid, 2% of cetyl alcohol, 1.2% of base oil, 2.5% of cyclopenta dimethyl siloxane, 5.5% of bis-PEG-15 methyl ether dimethyl siloxane, 0.5% of ammonium acryloyl dimethyl taurate/VP copolymer, 3.5% of shea butter, 0.1% of essence, 5% of ethylhexyl hydrogenated olivate oleate, 0.1% of disodium EDTA, 1% of lipoic acid, 5% of humectant and the balance deionized water.
Wherein the small nucleic acid active component consists of 60 percent of MITF-sRNA, 30 percent of TYR-sRNA and 10 percent of TYRP-sRNA in percentage by weight of the total weight of the small nucleic acid active component;
example 3:
a skin care product capable of rapidly and safely removing freckles comprises, by weight, 0.03% of active ingredient of small nucleic acid, 4% of polyhydrogenated polydecene, 3% of sorbitan olivate, 2.5% of stearic acid, 2.5% of cetyl alcohol, 1.8% of base oil, 2% of cyclopenta dimethyl siloxane, 5% of bis-PEG-15 methyl ether dimethyl silicone, 0.3% of acryloyl dimethyl ammonium taurate/VP copolymer, 3% of shea butter, 0.1% of essence, 5% of hydrogenated ethylhexyl olivate, 0.1% of EDTA disodium, 1% of lipoic acid, 5% of humectant and the balance deionized water.
Wherein the small nucleic acid active component consists of 90 percent of MITF-sRNA, 5 percent of TYR-sRNA and 5 percent of TYRP-sRNA in percentage by weight of the total weight of the small nucleic acid active component;
the activity experiment of the skin care product for quickly removing the spots by using the small nucleic acid in the embodiment 1 is as follows:
subject 1: after the skin care product is used, the butterfly spot is obviously reduced, the skin brightness is improved and is whitened a little after one month.
Subject 2: after the face is washed in the morning and evening every day, the product in the example 1 is uniformly applied to the spot on the face, the chloasma becomes obviously lighter after one month, the chloasma basically disappears after three months, the skin is obviously white, and the effect is good.
Subject 3: after the face is washed in the morning and evening every day, the product in the example 1 is uniformly applied to the spot on the face, and after one month, the chloasma becomes obviously lighter, so that the senile plaques on the skin are obviously improved.
So far, the technical solutions of the present invention have been described in connection with the preferred embodiments, but it is easily understood by those skilled in the art that the scope of the present invention is obviously not limited to these specific embodiments. Equivalent changes or substitutions of related technical features can be made by those skilled in the art without departing from the principle of the invention, and the technical scheme after the changes or substitutions can fall into the protection scope of the invention.
Claims (10)
1. A skin care product for rapidly and safely removing freckles from small nucleic acids is characterized by comprising 0.001-0.03% of small nucleic acid active ingredients and 99.97-99.999% of cosmetic auxiliary materials in percentage by mass.
2. The small nucleic acid skin care product capable of rapidly and safely removing freckles according to claim 1, wherein the small nucleic acid active ingredients comprise the following components in percentage by weight: MITF-sRNA 30-90%, TYR-sRNA 5-60% and TYRP-sRNA 5-30%.
3. The small nucleic acid skin care product capable of rapidly and safely removing freckles according to claim 2, wherein the small nucleic acid active ingredients comprise the following components in percentage by weight: MITF-sRNA 60%, TYR-sRNA 30%, TYRP-sRNA 10%.
4. The small nucleic acid fast and safe freckle-removing skin care product according to claim 1, wherein the cosmetic auxiliary materials comprise polyhydrodecacene, sorbitan olivate, stearic acid, cetyl alcohol, base oil, cyclopentadimethylsiloxane, bis-PEG-15 methyl ether polydimethylsiloxane, acryloyldimethyl ammonium taurate/VP copolymer, shea butter, essence, hydrogenated ethylhexyl olivate, EDTA disodium, lipoic acid, a humectant and water.
5. The small nucleic acid skin care product capable of rapidly and safely removing freckles is characterized in that the small nucleic acid skin care product comprises 0.004% of small nucleic acid active ingredients and 99.996% of cosmetic auxiliary materials.
6. The small nucleic acid skin care product capable of rapidly and safely removing freckles according to claim 4, which is characterized by comprising the following components in percentage by weight: 0.004% of small nucleic acid active ingredient, 3.5% of polyhydrodecarens, 3% of sorbitan olivate oleate, 1.8% of stearic acid, 2% of cetyl alcohol, 1.2% of base oil, 2% of cyclopentadimethylsiloxane, 5% of bis-PEG-15 methyl ether polydimethylsiloxane, 0.4% of acryloyl dimethyl taurate/VP copolymer, 3% of shea butter fruit resin, 0.15% of essence, 4% of hydrogenated olive oil ethylhexyl oleate, 0.1% of EDTA disodium, 1% of lipoic acid, 5% of humectant and the balance of water.
7. The small nucleic acid fast and safe freckle-removing skin care product according to claim 6, wherein the base oil is jojoba oil, dimethicone, or a mixture thereof.
8. The small nucleic acid skin care product for rapidly and safely removing freckles according to claim 6, wherein the moisturizer is glycerin, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol/octanediol, hyaluronic acid, glyceryl caprylate, or a mixture of two or more thereof.
9. The small nucleic acid fast and safe freckle removing skin care product according to claim 1, wherein the balance is deionized water.
10. The rapid and safe depigmenting skin care preparation as claimed in claim 1, wherein said copolymer of ammonium acryloyldimethyltaurate/VP can be composed of xanthan gum, or a mixture of xanthan gum and copolymer of ammonium acryloyldimethyltaurate/VP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010689579.2A CN111956519A (en) | 2020-07-17 | 2020-07-17 | Small nucleic acid skin care product capable of quickly and safely removing freckles |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010689579.2A CN111956519A (en) | 2020-07-17 | 2020-07-17 | Small nucleic acid skin care product capable of quickly and safely removing freckles |
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| CN111956519A true CN111956519A (en) | 2020-11-20 |
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| CN202010689579.2A Pending CN111956519A (en) | 2020-07-17 | 2020-07-17 | Small nucleic acid skin care product capable of quickly and safely removing freckles |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113749962A (en) * | 2021-09-17 | 2021-12-07 | 孔冰冰 | Preparation method of small nucleic acid acne and freckle removing composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705392A (en) * | 2012-09-29 | 2014-04-09 | 黄兵 | Small nucleic acid whitening and freckle-removing cream, and preparation method thereof |
| CN106420792A (en) * | 2016-09-21 | 2017-02-22 | 百奥迈科生物技术有限公司 | Micro-nucleic acid acne-removing compound |
| CN110090165A (en) * | 2019-05-08 | 2019-08-06 | 浙江大学 | A kind of small nucleic acids nano whitening frost and preparation method and application |
-
2020
- 2020-07-17 CN CN202010689579.2A patent/CN111956519A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705392A (en) * | 2012-09-29 | 2014-04-09 | 黄兵 | Small nucleic acid whitening and freckle-removing cream, and preparation method thereof |
| CN106420792A (en) * | 2016-09-21 | 2017-02-22 | 百奥迈科生物技术有限公司 | Micro-nucleic acid acne-removing compound |
| CN110090165A (en) * | 2019-05-08 | 2019-08-06 | 浙江大学 | A kind of small nucleic acids nano whitening frost and preparation method and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113749962A (en) * | 2021-09-17 | 2021-12-07 | 孔冰冰 | Preparation method of small nucleic acid acne and freckle removing composition |
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