KR20090056300A - Cosmetic composition for improving the skin elasticity - Google Patents

Abstract

A cosmetic composition for improving the skin elasticity and wrinkle is provided by improve dermis-epidermis layer by efficiently absorbing an efficient component and enhance skin elasticity. A cosmetic composition for enhancing the skin elasticity comprises 0.01-10.0% by weight of soluble film former, 1.0-40.0% by weight of polyhydric alcohol, 1.0-20.0% by weight of polar oil, and efficient component of elasticity improvement. The soluble film former is hydroxyethylacrylate/sodiumacryloyldimethyltaurate copolymer, polyvinylpyrrolidone, vinylpyrrolidone vinylacetate copolymer, polyquaternium hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose or hydroxypropyl guar. The polyhydric alcohol is glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol or sorbitol. The polar oil is ester oil. The efficient component of elasticity improvement is retinol, adenosine or peptide. The cosmetic composition is used in a form of emulsion of oil in water(O/W) or water in oil(W/O), lotion, cream, emulsion, patch, stick or spray.

Description

Cosmetic composition for enhancing skin elasticity {Cosmetic composition for improving the skin elasticity}

The present invention relates to a cosmetic composition containing a water-soluble film former, polyhydric alcohol, polar oil and elasticity enhancing ingredients to enhance skin elasticity and improve wrinkles.

Skin elasticity is represented by elastic fibers composed of elastin in the dermis, which has a very low modulus of elasticity, such as rubber, which is easily deformed by small forces and easily removed when the forces are removed. Come back to the circle. In addition, elastic fibers have a form in which microfibrils are embedded in an amorphous matrix called elastin, and elastin is a unique feature found only in elastic fibers called desmosine and isodesmosine derived from lysine. A protein composed of amino acids. These desmosin and isodesmosin form cross-links in long peptide chains, which give elastin a rubbery property.

In addition, the elastic fiber composed of elastin is present along with collagen fibers called collagen, which is sufficient to maintain skin elasticity in a state where elastin and collagen are sufficiently present.

On the other hand, the decrease in skin elasticity is caused by a decrease in the production and destruction of elastin due to the weakening of skin cells (fibroblasts) due to aging and ultraviolet light. Elastin degrading enzyme is expressed in the skin by ultraviolet rays, and this enzyme decomposes normal elastin in the skin, resulting in decreased skin elasticity. Decreased skin elasticity is also caused by damage to and production of a protein called collagen, which makes up 70% or more of the dermis of the skin. Collagen is also broken down by a degrading enzyme called collagenase, which is caused by ultraviolet light.

The prior art generally uses an agonist that inhibits the activity of collagenase or inhibits the activity of elastase for skin elasticity enhancing effect. This technology does not give the skin an immediate sense of elasticity, simply by using the active ingredient as an effective ingredient is effectively absorbed by the skin is limited to demonstrate the efficacy.

Therefore, the satisfaction of existing skin elasticity improvement products is low, and the development of a cosmetic having excellent skin elasticity and enhancement effect as well as providing immediate elasticity has become an urgent and important problem.

Accordingly, the present inventors have been trying to develop a cosmetic that gives a sense of elasticity and moisturization, wrinkles and wrinkles with continuous use while giving elasticity to the skin at the same time, skin moisturizing membrane, barrier function, skin permeability of the active ingredient, absorbency As a result of investigating the factors affecting, the difference between the ingredients and the contents was found and the present invention was completed.

Therefore, an object of the present invention is to provide a feeling of elasticity to the skin by forming a flexible film on the skin so that the elasticity-improving effect component is effectively absorbed by the skin to fully demonstrate the efficacy and soften the stratum corneum layer, so that the effect component is well absorbed into the skin and moisture protective film By increasing the moisturizing effect and to improve the delivery of the active ingredient in the skin to provide an effective cosmetic composition for improving skin elasticity.

In order to achieve the above object, the present invention provides a cosmetic composition for enhancing skin elasticity containing a water-soluble filmformer, polyhydric alcohol, polar oil and elasticity improving efficacy component.

The cosmetic composition for enhancing skin elasticity according to the present invention contains a water-soluble filmformer, polyhydric alcohol, polar oil, and elasticity improvement ingredient more than a predetermined amount to provide immediate elasticity to the skin and to be effectively absorbed by the skin without loss of efficacy substances. And by improving the dermal-epidermal layer by continuous use, it ultimately improves skin elasticity.

The cosmetic composition for enhancing skin elasticity of the present invention contains a water-soluble film former, polyhydric alcohol, polar oil, and elasticity improving efficacy ingredient.

Hereinafter, the present invention will be described in more detail.

In the cosmetic composition according to the present invention, water-soluble film formers are used to impart instant elasticity to the skin and to enhance moisturization and absorption of active ingredients through the formation of a flexible skin protective film.

The water-soluble film former is contained in an amount of 0.01 to 10.0% by weight, preferably 0.1 to 2.0% by weight based on the total weight of the composition. If it contains less than 0.01% by weight, the desired film feeling is not obtained, and if it contains more than 10.0% by weight, there is a problem in that it is difficult to commercialize because the use is not good.

As the water-soluble film former used in the present invention, an acrylamide, acrylic acid, fippy, polyquaternium and polysaccharide-based polymer or a copolymer thereof may be used. Specifically, hydroxyethyl acrylate / sodium acryl Royldimethyltaurate copolymer, polyvinylpyrrolidone, vinylpyrrolidone vinyl acetate copolymer, polyquaternium hydroxyethyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropyl guar, and the like. Among these, 1 or more types can be selected and used.

In addition, in the cosmetic composition of the present invention, polyhydric alcohols are used as moisturizing ingredients to soften the keratin and soften the lipid components between epidermal cells so that the effective ingredient is absorbed and diffused into the skin.

The polyhydric alcohol is contained in an amount of 1.0 to 40.0% by weight, preferably 10.0 to 20.0% by weight, based on the total weight of the composition. If it is contained less than 1.0% by weight can not achieve the desired keratin softening and moisturizing effect, if it contains more than 40.0% by weight is not good to use the product is difficult to produce a problem.

Specifically, there are glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, and the like, and one or more kinds thereof can be selected and used.

In the cosmetic composition of the present invention, natural oil or synthetic oil may be used as an oil component, and hydrocarbon, triglyceride, ester or silicone oil may be used. The oil component is contained in an amount of 1.0 to 40.0% by weight, preferably 5.0 to 20.0% by weight, based on the total weight of the composition. If the content is less than 1.0% by weight, it is difficult to obtain the desired emulsion formulation, and if it is more than 40.0% by weight, the stability of the emulsifier type is deteriorated .

When the proper amount of polar oil is used in the oils used, the keratin becomes soft and the skin permeability of the contents is improved, so that the elasticity improving efficacy ingredient can penetrate into the skin more evenly and deeply to inhibit the activity of collagenase or elastase. Efficacy will increase. Therefore, in the cosmetic composition according to the present invention, the polar oil is contained in an amount of 1.0 to 20.0% by weight, preferably 3.0 to 10.0% by weight, based on the total weight of the composition. If it is contained less than 1.0% by weight, it is difficult to obtain the desired skin absorption enhancement effect, and if it contains more than 20.0% by weight, there is a problem that the stability of the emulsifier type worsens .

The polar oil used in the present invention is particularly an ester oil, and more specifically isopropyl myristate, isopropyl palmitate, cetyl ethylhexanoate, alkyl benzoate having 12 to 15 carbon atoms, dicaprylyl carbonate and pentaerythritol It is not limited to one or more selected from the group consisting of tetraethylhexanoate, pentaerythritol tetraisostearate and diisostearyl maleate.

The cosmetic composition according to the present invention contains a skin elasticity improving efficacy ingredient. Specific examples include oleanolic acid, retinol, adenosine, peptide, and the like, and one or more selected from these are used. The content used is a general content in which the effect of the active ingredient is recognized, in the present invention, oleanolic acid was used 0.05% by weight relative to the total weight of the composition.

Cosmetic compositions according to the invention can be formulated in oil-in-water (O / W) or water-in-oil (W / O) emulsions, and can be formulated in the form of lotions, creams, emulsions, patches, sticks or sprays.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples. However, these examples and test examples are only for the understanding of the present invention, and the scope of the present invention in any sense is not limited only to these examples.

Reference Example Preparation of Cosmetics for Enhancing Skin Elasticity

As shown in Table 1, by changing the content (wt%) of the polar oil, polyhydric alcohol, film forming agent, the cosmetic composition containing oleanolic acid as in Examples 1 to 7 and Comparative Examples 1 to 2 (water-in-oil) (O / W) emulsion formulations) were prepared. Comparative Example 1 is an example of preparing a basic O / W emulsion base, Comparative Example 2 is the addition of oleanolic acid to Comparative Example 1. Example 1 is an example containing a polyhydric alcohol in the formulation of Comparative Example 2, Example 2 is an example used to increase the type and content of the polyhydric alcohol than Example 1. Example 3 was prepared by the addition of the water-soluble film hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer in the formulation of Comparative Example 2, Example 4 was prepared as a water-soluble film former in the formulation of Comparative Example 2 Polyvinylpyrrolidone is used. Examples 5 and 6 use ester oil which is polar oil instead of hydrocarbon oil in the formulation of Comparative Example 2. Example 7 uses all of polyhydric alcohol, film former and polar oil in the formulation of Comparative Example 2.

division Raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Water component Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 Disodium ID 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 glycerin 5 5 - - - - 5 - - Butylene Glycol - 10 - - - - 10 - - Hydroxyethylacrylate / Sodium Acryloyldimethyl Taurate Copolymer - - 0.5 - - - 0.5 - - Polyvinylpyrrolidone - - - 0.5 - - - - - Oily ingredients Cetyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Cetearyl Alcohol / Cetearyl Glucoside 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Glyceryl Stearate / Fiji-100 Stearate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Pentaerythritol tetraethylhexanoate - - - - 15 15 - - 7-ethylhexanoate - - - - - 15 - - - Hydrogenated Polydesin 15 15 15 15 - - - 15.0 15.0 Base Ethyl alcohol 0.3 0.3 0.3 0.3 0.3 0.3 0.3 - 0.3 Propylene glycol 0.1 0.1 0.1 0.1 0.1 0.1 0.1 - 0.1 Oleanolic acid 0.05 0.05 0.05 0.05 0.05 0.05 0.05 - 0.05 Etc antiseptic Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Spices Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity

<The manufacturing method of Examples 1-7 and Comparative Examples 1-2>

(1) The aqueous phase components are uniformly mixed and dissolved by heating at 70 ° C.

(2) The oily ingredients are mixed and dissolved by heating at 75 ° C.

(3) The above (2) is slowly added to the above (1) while stirring (homomixing) at 70 ° C to form an emulsion (oil-in-water emulsion) formulation.

(4) The oleanolic acid base is stirred at 60 DEG C and cooled to 40 DEG C or lower after dissolution.

(5) After (3) is cooled to 40 ° C. or lower, (4) is added and stirred to mix uniformly.

Test Example 1 Collagen Production Promoting Effect

Inhibition of collagenase activity was measured by treating the fibroblasts obtained directly from human or commercially purchased human fibroblasts. The contents prepared by the prescription of Comparative Examples 1 and 2 were used as samples, and the experimental method was as follows.

Human fibroblasts were placed in a culture flask and incubated until about 70-80% growth. Thereafter, the samples were treated for 1 day, and then the cell culture medium was collected and collagen production was measured using a commercially available collagenase activity measuring instrument (Anal Biochem 116 (1): 172-7, 1987 "An assay of collagenase). activity using enzyme-linked immunosorbent assay for mammalian collagenase ". In other words, using an antibody against collagenase, Matrix Metalloproteinase-1 (MMP-1), an enzyme that degrades collagen derived from humans, was quantified. The results are shown in Table 2 below.

sample Activity inhibition rate (%) Comparative Example 1 0 Comparative Example 2 48

Since Comparative Example 2 further contains oleanolic acid in the composition of Comparative Example 1, the collagen production promoting effect of oleanolic acid can be confirmed from Table 2 above.

In fact, when applied to human skin in order to ensure that the elasticity-enhancing ingredients such as oleanolic acid is effectively absorbed by the skin to fully exhibit the efficacy, emulsion formulations are generally advantageous for skin absorption rather than solubilized formulations. Therefore, in the following test, the factors affecting the elasticity improvement effect in oil-in-water emulsion formulations were identified and their effects were confirmed.

[Test Example 2] effect of enhancing the elasticity of the water-soluble film former

In order to confirm the effect of improving skin elasticity immediately after using the product, the cream formulations having the compositions of Examples 3 and 4 and Comparative Example 2 were used for 20 Korean women in their 30s and then evaluated for immediate feeling of use. The results are shown in Table 3 below.

Feeling item Comparative Example 2 Example 3 Example 4 Feels like lifting up struck skin. - 8 6 The skin feels elastic 8 12 10 I do not know. 12 - 4

From Table 3, it can be seen that the skin elasticity is immediately sensed when the water-soluble polymer is used, and that the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer has a better elasticity than vinylpyrrolidone. This indicates that in the case of hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, a film is formed in a microgel type to form a flexible film on the skin, thereby feeling a higher skin elasticity.

Test Example 3 Skin Elasticity Enhancement Effect

Elasticity of the skin using a cutometer (Cutometer, Courage + Khazaka Electronic GmbH., Cologne, Germany), a device that measures skin elasticity by applying negative pressure to the skin to measure the skin elasticity enhancing effect after using the product The degree was measured. The skin elasticity of 60 Korean women in their 30s was measured, and 36 women with mean values ranging from 0.7 to 0.73 were selected. Again, four people having an average value of about 0.71 were grouped into nine groups, and the compositions of Examples 1 to 7 and Comparative Examples 1 and 2 were used. Skin elasticity and skin elasticity recovery were measured after 4 weeks of use. Table 4 and Figure 1 shows the value measured by the total skin elasticity of each subject after 4 weeks of use, Table 5 and Figure 2 shows the skin elastic recovery of each subject after 4 weeks of use.

Total skin elasticity after 4 weeks of use Before use Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Measured value (AU) 0.712 0.783 0.816 0.802 0.781 0.778 0.774 0.847 0.723 0.752

Skin elasticity recovery after 4 weeks Before use Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Measured value (AU) 0.245 0.292 0.305 0.298 0.291 0.289 0.284 0.317 0.252 0.272

In Tables 4 and 5, after using Examples 1 to 7 and Comparative Examples 1 to 2, both skin elasticity and skin elastic recovery were enhanced, but Examples 1 to 7 were used when Comparative Examples 1 to 2 were used. It can be seen that the skin elasticity and elastic recovery degree is better than when used.

In Examples 1 and 2 it can be seen that through the use of polyhydric alcohol through the higher skin elasticity and skin elasticity recovery than Comparative Example 2, the skin absorption of the agonist is increased, thereby improving the skin elasticity improving effect. In addition, since Example 2 is higher than Example 1, it can be seen that the effect is greatly increased when using 10% by weight or more of polyhydric alcohol.

In addition, in Examples 3 and 4, the skin elasticity and skin elastic recovery are higher than that of Comparative Example 2, so that a film is formed on the skin by using a water-soluble film former, so that absorption of the agonist material is not lost and the absorption is promoted into the skin. Able to know. In addition, when the hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer was used, the thick and elastic film of the microgel type | mold was formed, and polyvinylpyrrolidone was used because Example 3 has a higher measured value than Example 4. It can be seen that the effect is higher than when used.

In addition, in Examples 5 and 6, skin elasticity and skin elastic recovery are higher than that of Comparative Example 2, so that the use of polar oil softens the keratin and softens the intercellular lipids of the epidermal layer, thereby increasing the skin absorption of the agonist. It can be seen that diffusion is promoted. Since the difference in the measured values of Examples 5 and 6 is not large, it can be seen that there is almost no difference in the results according to the difference in the ester oils contained therein.

In addition, in Example 7, skin elasticity and skin elastic recovery after 4 weeks of use were measured much higher than Examples 1-6 and Comparative Examples 1-2. From this, it can be seen that when the water-soluble film former, polyhydric alcohol, and polar oil are used together at a specific content or more, the skin elasticity enhancing effect is greatly increased.

Test Example 4 Skin Dermal Density Enhancement Effect

In order to measure the change of dermal dermal layer after using the product, dermal thickness and density were measured on the face cheek surface by using Dermascan C (Cortex, Denmark), an ultrasonic device. Skin densities of 60 Korean women in their 30s were measured, and 36 women with mean values ranging from 23.0% to 23.2% were selected. Again, four people having an average value of about 23.1% were grouped into nine groups, and the compositions of Examples 1 to 7 and Comparative Examples 1 and 2 were used. Dermal layer thickness change and dermal density were measured after 4 weeks of use. Table 6 and Figure 3 shows the change in the thickness of the dermal layer by subject after 4 weeks, Table 7 and Figure 4 shows the dermal density of the subject after 4 weeks.

Dermal layer thickness change after 4 weeks Before use Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 Distance (AU) 1.35 1.68 1.71 1.7 1.63 1.67 1.59 1.74 1.35 1.48

Dermal pitch density after 4 weeks Before use Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Comparative Example 1 Comparative Example 2 burglar(%) 23.1 24.5 24.7 24.6 24.3 24.3 24.2 24.9 23.3 23.8

Looking at the Table 6 and Table 7, the skin dermis thickness and density were improved after using Examples 1 to 7 and Comparative Example 2, the skin dermis thickness compared to the case of using Examples 1 to 7 compared to the case of using Comparative Example 2 And it can be seen that the increase of the density is greater.

In the case of Examples 1 and 2, the change in the thickness of the dermis layer and the dermal density were higher than those of Comparative Example 2, indicating that the use of polyhydric alcohol increases the skin absorption of the agonist, resulting in a thicker dermal layer and improved skin density. Can be. In addition, since Example 2 is higher than Example 1, it can be seen that the effect is greatly increased when using 10% by weight or more of polyhydric alcohol.

In addition, in the case of Examples 3 and 4, the change in the thickness of the dermis layer and the dermal density is higher than that of Comparative Example 2, so that the film is formed on the skin by use of the water-soluble film former, so that the absorption of the agonist is promoted into the skin without loss of agonist. Able to know. In addition, when the hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer was used, the thick and elastic film of the microgel type | mold was formed, and polyvinylpyrrolidone was used because Example 3 has a higher measured value than Example 4. It can be seen that the effect is higher than when used.

In addition, in Examples 5 and 6, the change in the thickness of the dermal layer and the dermal density were higher than those of Comparative Example 2, thereby softening the keratin with the use of polar oil and softening the intercellular lipids of the epidermal layer, thereby increasing the skin absorption of the agonist. It can be seen that diffusion is promoted.

In addition, in Example 7, the thickness change and the dermal density of the dermis layer after 4 weeks of use were much higher than those of Examples 1 to 6 and Comparative Examples 1 to 2. From this, it can be seen that when the water-soluble film former, polyhydric alcohol, and polar oil are used together at a specific content or more, the thickness change of the dermal layer and the dermal density are greatly increased.

Cosmetic composition for enhancing skin elasticity according to the present invention is not limited to the formulations of the above examples and comparative examples, lotion, cream, emulsion, patch, stick in oil-in-water (O / W) or water-in-oil (W / O) emulsion formulation Or in the form of sprays.

1 is a graph showing the total skin elasticity after using Examples 1 to 7 and Comparative Examples 1 to 2 for 4 weeks.

2 is a graph showing skin elastic recovery after using Examples 1 to 7 and Comparative Examples 1 to 2 for 4 weeks.

3 is a graph showing changes in the dermal layer thickness after using Examples 1 to 7 and Comparative Examples 1 to 2 for 4 weeks.

4 is a graph showing the dermal density after using Examples 1 to 7 and Comparative Examples 1 to 2 for 4 weeks.

Claims (10)

A cosmetic composition for enhancing skin elasticity, comprising a water-soluble film former, polyhydric alcohol, polar oil, and elasticity improving ingredient. The cosmetic composition for improving skin elasticity according to claim 1, wherein the water-soluble film former is contained in an amount of 0.01 to 10.0% by weight based on the total weight of the composition. The method of claim 1, wherein the water-soluble film former is hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, polyvinylpyrrolidone, vinylpyrrolidone vinyl acetate copolymer, polyquaternium hydroxyethyl cellulose, Cosmetic composition for improving skin elasticity, characterized in that at least one selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl cellulose and hydroxypropyl guar. The cosmetic composition for improving skin elasticity according to claim 1, wherein the polyhydric alcohol is contained in an amount of 1.0 to 40.0% by weight based on the total weight of the composition. The cosmetic composition for improving skin elasticity of claim 1, wherein the polyhydric alcohol is at least one selected from the group consisting of glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, and sorbitol. According to claim 1, wherein the polar oil is a cosmetic composition for improving skin elasticity, characterized in that it is contained in an amount of 1.0 to 20.0% by weight based on the total weight of the composition. The cosmetic composition for improving skin elasticity according to claim 1, wherein the polar oil is an ester oil. The method of claim 7, wherein the ester oil is isopropyl myristate, isopropyl palmitate, cetyl ethyl hexanoate, alkyl benzoate of 12 to 15 carbon atoms, dicaprylyl carbonate, pentaerythryl tetraethylhexanoate, penta Cosmetic composition for improving skin elasticity, characterized in that at least one selected from the group consisting of erythryl tetraisostearate and diisostearyl maleate. The cosmetic composition for improving skin elasticity according to claim 1, wherein the elasticity improving efficacy ingredient is at least one selected from the group consisting of oleanolic acid, retinol, adenosine and peptide. The method of claim 1, wherein the cosmetic composition is an oil-in-water (O / W) or water-in-oil (W / O) emulsion formulation, skin elasticity, characterized in that the formulation of the lotion, cream, emulsion, patch, stick or spray Improvement cosmetic composition.

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