KR101986513B1 - Cosmetic Composition for Lip Anti-aging Comprising Tocopheryl Acetate as an Effective Ingredient - Google Patents

Abstract

There is provided a cosmetic composition for prevention or improvement of lip aging, comprising Tocopheryl Acetate, Dipalmitoyl Hydroxyproline, Ceramide and Panthenol.

Description

[0002] Cosmetic Composition for Lip Anti-aging Comprising Tocopheryl Acetate as an Effective Ingredient [0003]

This application claims the benefit of priority based on Korean Patent Application No. 10-2016-0095435, filed on July 27, 2016, the entire contents of which are incorporated herein by reference.

The present invention relates to a cosmetic composition for the anti-aging of the lips comprising tocopheryl acetate as an active ingredient.

Skin aging occurs with aging. Skin aging is caused by factors such as (i) irritation of the skin structure and physiological functions of the body as a result of aging, and intrinsic aging, and extrinsic aging induced by external factors such as ultraviolet rays, dry air, reactive oxygen species (ROS), stress, and the like. Endogenous aging is caused by fine lines, , And elasticity decrease, and extrinsic aging exhibits clinical characteristics such as coarse and deep wrinkles as well as fine wrinkles. Therefore, such skin elasticity reduction and wrinkle are representative symptoms of skin aging described above have.

As shown above, skin elasticity is reduced and wrinkles are caused by collagen (collagen), which is a major component of the extracellular matrix (ECM) in the dermis of the skin. Collagen is synthesized in fibroblasts. It is present in high concentration in the skin, plays a role of skin firmness, resistance of connective tissues and binding force of tissues, cell adhesion, cell division and induction of differentiation, It is not affected by degrading enzymes but is degraded by collagenase.

MMPs (matrix metalloproteinases) are typical enzymes that exhibit collagenase activity. These MMPs decompose connective tissue components including collagen of skin dermis. Therefore, when the activity of MMPs is increased, collagen content in skin tissue The skin elasticity is lowered and wrinkles are induced. MMP-1, MMP-2, and MMP-9 act mainly in the skin. MMP-1 is the most fundamental enzyme involved in collagen degradation. It has been reported that the activity of these MMPs increases with the irradiation dose of ultraviolet light. Particularly, ultraviolet B (UVB) generates ROS in the skin cells and causes direct DNA damage, thereby causing oxidative stress caused by imbalance of antioxidant defense system Not only induces wrinkles by increasing the activity of MMPs, but also by degradation, cleavage and abnormal cross-linking of connective tissue components. Ultimately, ROS by ultraviolet light is a major cause of skin aging, which increases wrinkles by increasing MMPs and reducing collagen production and elastic fiber synthesis.

On the other hand, the lips are constantly contracted and swollen to be not only the most moveable parts of the body parts, but they are always exposed to the outside and are easily affected by environmental factors such as ultraviolet rays. Particularly, since the lips have a structure different from that of normal skin and have no sebaceous membrane and the stratum corneum is very thin, the skin is vulnerable to extrinsic aging due to its weak defense ability against external stimuli such as ultraviolet rays, It is a kind of skin, and as it gets older, it undergoes endogenous aging, in which elasticity is reduced and wrinkles are generated. As a result, in addition to the increase in wrinkles on the lips, the original elasticity is lost and the lip gradually becomes loosened and the lips are struck.

Accordingly, it is necessary to develop a cosmetic having an excellent effect for improving the elasticity and wrinkles even in the case of lips, as in general skin, and in particular, in the case of lips, the cosmetic may be drawn into the oral cavity adjacent to the oral cavity , It is necessary to develop cosmetics that are safe to human body while having superior elasticity and wrinkle-improving effect on the lips.

On the other hand, 'tocopheryl acetate' is a vitamin E acetate that protects skin from harmful oxygen that causes extrinsic aging and suppresses the oxidation of unsaturated fatty acids constituting the cell membrane, thereby inhibiting endogenous aging and exogenous aging, It is known as an effective ingredient for prevention.

However, as mentioned above, the lips are composed of a thin stratum corneum unlike the other skin, so that they are more sensitive and sensitive to external preparations than ordinary skin. Therefore, even though they have excellent effects in preventing elasticity and wrinkles, There was a problem that accompanied by side effects caused by stinging or pain.

In addition, the lips are areas where contact with the tongue or teeth and contact with various tools for taking food are frequent, and even when the external preparations are applied, they are easily erased by contact with the outside so that before the cosmetic exhibits a substantial effect on the lips There was an inconvenience that it would be erased or the external preparation should be applied more frequently and in a large amount.

The present inventors have recognized that there is a need for market and a realistic problem of the external preparation for lips, and it is an object of the present invention to provide a cosmetic composition which is excellent in the elasticity and wrinkle effect of the lips without adverse effects on the living body, It has been found that the cosmetic composition comprising tocopheryl acetate and a predetermined additional ingredient exhibits an excellent effect in improving the elasticity and wrinkles of the lips, And the present invention has been completed.

SUMMARY OF THE INVENTION It is an object of the present invention to solve the above-mentioned problems of the prior art and the technical problems required from the past.

It is an object of the present invention to provide a lip skin external preparation which not only exerts an excellent effect of improving the elasticity and wrinkles of lips but also has no adverse effects on the living body even when it enters the living body as a lip external preparation.

Accordingly, in order to accomplish the above object, the present invention provides a cosmetic composition for prevention or improvement of lip aging,

Tocopheryl Acetate, Dipalmitoyl Hydroxyproline, Ceramide NP, and Panthenol.

The cosmetic composition may further comprise 0.1 to 10% by weight of tocopheryl acetate, 0.001 to 1% by weight of dipalmitoyl hydroxyproline, 0.001 to 1% by weight of ceramide, and 0.001 to 1% by weight of panthenol based on the total weight of the cosmetic composition.

In addition, the cosmetic composition may further comprise a skin softening polymer. Specifically, the skin softening polymer may include dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate, dipentaerythritol tri- Polyhydroxystearate, polyglyceryl-2 isostearate / dimer dilinoleate copolymer, hydrogenated castor oil dimer dilinoleate, polyglyceryl-10 nonisostearate, and phytosteryl / isostearyl / Cetyl / stearyl / behenyl dimer dilinoleate.

More specifically, the skin softening polymer is dipentaerythritol hexahydroxystearate / hexa stearate / hexa rogninate and polyglyceryl-2 isostearate / dimer dilinolite copolymer,

In addition, when the skin softening polymer includes dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate, dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate may be added to the total weight of the cosmetic composition By weight based on the total weight of the composition.

In addition, when the above polyglyceryl-2 isostearate / dimer dilinoleate copolymer is included, the polyglyceryl-2 isostearate / dimer dilinoleate copolymer may be used in an amount of 0.01 to 5 parts by weight, 3% by weight.

The cosmetic composition for preventing or improving the aging of the lips according to the present invention is an external preparation for lips skin. The external preparation has no side effects on the human body and exerts an excellent effect on improving elasticity and wrinkles by acting specifically on the lips.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a graph comparing wrinkle improvement rates of the cosmetic compositions of the examples and the comparative examples;
Fig. 2 is a photograph of a subject having symptoms of flushing caused by the cosmetic composition of Comparative Example 9; Fig.
Fig. 3 is a photograph of a subject having symptoms of edema generated according to Comparative Example 10 cosmetic material. Fig.

Hereinafter, the present invention will be described in detail.

The present invention provides a cosmetic composition for prevention or improvement of lip aging.

Tocopheryl acetate, also known as vitamin E acetate, has a structure in which tocopherol (vitamin E) and acetic acid are linked by an ester bond, as shown in the following formula (1).

Tocopheryl acetate has the effect of protecting skin from harmful oxygen and preventing the oxidation of unsaturated fatty acids constituting the cell membrane.

Unlike normal skin, it has no pores, and the thin stratum corneum composed of 3 to 4 layers is vulnerable to external harmful substances and stimuli. In addition, it is sensitive to cosmetic ingredients applied to lip skin and sensitively used. It is necessary to optimize it to suit the use of the lips.

In the case of the cosmetic composition for prevention or improvement of lips according to the present invention, it is preferable that the composition of the cosmetic composition for lip resurfacing or improvement is selected from the group consisting of Tocopheryl Acetate, Dipalmitoyl Hydroxyproline, Ceramide and Panthenol, And wrinkles, and is particularly suitable for use as a lip external preparation.

The Dipalmitoyl Hydroxyproline has a structure represented by the following Chemical Formula 2, and has a molecular structure in which hydroxyproline forms peptide bonding and ester bonding with two units of palmitoleic acid. It is effective for skin elasticity and wrinkle improvement, and is effective ingredient for skin elasticity improvement.

The cosmetic composition of the present invention includes ceramide. Ceramide is one of intercellular lipid components constituting the stratum corneum of the skin. It constitutes at least 40% of the skin lipids and plays a role of maintaining the skin barrier. Therefore, It is necessary to maintain or replenish the ceramide.

Ceramides play a role of improving the skin such as moisturizing the skin and restoring the skin barrier when applying the skin, and there are nine kinds of ceramides constituting the skin. The ceramide contained in the cosmetic composition according to the present invention is at least one selected from the group consisting of ceramide 1 (EOS), ceramide 2 (NS), ceramide 3 (NP), ceramide 4 (EOH), ceramide 5 (AS), ceramide 6 AP), ceramide 8 (AH) and ceramide 9 (EOP). In the present invention, Ceramide 3 is used, which is capable of suppressing moisture evaporation and imparting a moisturizing effect, but is not limited thereto.

Panthenol of the following formula (3) is a precursor of vitamin B5 itself, which stimulates skin regeneration and improves the moisturizing and maintaining function of the skin. However, it is included as one component of the cosmetic composition of the present invention, When applied, it stimulates the regeneration of the ingredients in the lips skin, thereby further improving the elasticity and wrinkles of the lips skin.

In the case of the external preparation applied to the lip skin, it is necessary to be composed of a harmless substance that causes irritation in the living body because the tongue and teeth of the person are frequently contacted with the mouth through the mouth and the lip is applied to the skin, It is necessary to improve the durability on the lips skin so as not to be erased even before it is made.

The cosmetic composition for prevention or improvement of lip aging according to the present invention is composed of components having particularly excellent effects on lip skin and is not only harmless to human body even though it is used for a long time as a lip external preparation, So that the above-mentioned components can be more effectively applied to the lips skin.

In particular, 0.1 to 10% by weight, preferably 0.5 to 8% by weight, more preferably 1 to 5% by weight, most preferably 2 to 4% by weight of tocopheryl acetate can be included in the total amount of the cosmetic composition .

Containing too much tocopheryl acetate can cause irritation to the lips and allergic reactions, and scars on the lips can worsen the scar.

In the case of dipalmitoyl hydroxyproline, 0.001 to 1% by weight, preferably 0.003 to 0.5% by weight, more preferably 0.005 to 0.1% by weight, most preferably 0.007 to 0.03% By weight to 1% by weight, preferably 0.003 to 0.5% by weight, more preferably 0.005 to 0.1% by weight, and most preferably 0.007 to 0.03% by weight.

When dipalmitoyl hydroxyproline is added in excess of the above amount, the formulation becomes unstable and it is difficult to prepare it as a cosmetic, and when excess ceramide is added, new skin layer growth on the lips surface is slowed, Falls.

In the case of panthenol, it may contain 0.001 to 1% by weight, preferably 0.003 to 0.5% by weight, more preferably 0.005 to 0.1% by weight, and most preferably 0.007 to 0.03% by weight. When panthenol is added in an amount exceeding the above-mentioned content, the viscosity of the cosmetic composition is improved, resulting in increased stickiness during use and a problem of poor feeling of use.

In addition, the cosmetic composition of the present invention may further comprise a skin softening polymer, and preferably, dipentaerythritol hexahydroxystearate / hexa stearate / hexa rosinate, dipentaerythritol tri-polyhydroxy Stearate, polyglyceryl-2 isostearate / dimer dilinoleate copolymer, hydrogenated castor oil dimer dilinoleate, polyglyceryl-10 nonisostearate, and phytosteryl / isostearyl / cetyl / Stearyl / behenyl dimer dilinoleate, and more preferably at least one selected from the group consisting of dipentaerythritol hexa hydroxystearate / hexa stearate / hexa rosinate and / or polyglyceryl-2 Lt; / RTI > stearate / isostearate / dimer dilinoleate copolymer.

More specifically, dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate may be included in an amount of 0.01 to 3% by weight, preferably 0.04 to 1% by weight, based on the total weight of the cosmetic composition, Preferably 0.06 to 0.5% by weight, and most preferably 0.08 to 0.3% by weight.

On the other hand, the polyglyceryl-2 isostearate / dimer dilinoleate copolymer may be contained in an amount of 0.01 to 3% by weight, preferably 0.05 to 1.5% by weight, more preferably 0.2 to 1.0% by weight, By weight, most preferably from 0.3 to 0.8% by weight.

If the dipentaerythritol hexahydroxystearate / hexa stearate / hexa rogninate and the polyglyceryl-2 isostearate / dimer dilinoleate copolymer are additionally included in the cosmetic composition according to the present invention in the abovementioned amounts Has a high sustained effect on the lips skin.

In addition to the above-mentioned components, the cosmetic composition of the present invention may further contain components conventionally used in cosmetic compositions such as fatty substances, organic solvents, solubilizers, thickeners and gelling agents, softeners, antioxidants, suspending agents, stabilizers, , A perfume, a surfactant, water, an ionic or nonionic emulsifier, a filler, a sequestering and chelating agent, a preservative, a vitamin, a barrier, a wetting agent, a essential oil, a dye, a pigment, a hydrophilic or lipophilic active agent, And the like may be included in an amount that is commonly used. In addition, the cosmetic composition of the present invention may be mixed with an organic UV blocking agent which has been used in the past so long as it reacts with the above-mentioned components and does not impair the lip aging prevention or improving effect.

Examples of the organic ultraviolet screening agent include glyceryl paraben, drometrizol trisiloxane, drometrizol, dicaloyl triolate, disodium phenyldibenzimidazole tetrasulfonate, diethylhexylbutamidotriazone, Hydroxybenzoylhexyl benzoate, di-methoxy cinnamate, a mixture of Rawson and dihydroxyacetone, methylenebis-benzotriazolyltetramethylbutylphenol, 4-methylbenzylidene camphor, menthyl anthranylate, benzophenone Benzophenone-4, benzophenone-8 (dioxyphenyl) benzene, butylmethoxydibenzoylmethane, bishexyloxyphenol methoxyphenyltriazine, synoxate, , Octocrylene, ethylhexylmethylmethylphenyl, ethylhexylmethoxy cinnamate, ethylhexylsalicylate, ethylhexyltriazone, isoamyl-p-methoxy cinnamate, polysilicon-15 (dimethicone, , Terephthalylidene decamepsulfophilic acid and salts thereof, tiei-salicylate and aminobenzoic acid (parabe), and the like may be used, but the present invention is not limited thereto.

In addition, the cosmetic composition of the present invention can be prepared into any formulation conventionally produced in the art for lip cosmetics in the art, and can be formulated into, for example, lip gloss, lip balm, lip balm, lip treatment and lipstick , But is not limited thereto.

Hereinafter, the present invention will be described in more detail by way of examples, but the scope of the present invention is not limited thereto.

Preparation of cosmetic composition for lips

As shown in the following Table 1, the lip cosmetic composition of the present invention containing tocopheryl acetate, Dipalmitoyl Hydroxyproline, Ceramide and Panthenol in a predetermined amount was added to the lip cosmetic composition of the present invention Were used to prepare cosmetic compositions of Comparative Examples in the form of a half body, and Comparative Examples of the cosmetic compositions having the components as shown in Tables 2 and 3 were prepared. At the time of manufacturing each cosmetic, a small amount of a red dye was added to the mixture to visually prepare a cosmetic composition so that the cosmetic composition of the present invention and the cosmetic composition of the comparative composition were visually identifiable.

All of the above-mentioned cosmetics are manufactured according to the Cosmetics Act, and raw materials that can not be used in cosmetics are not used at all. In the case of raw materials requiring restriction in use, they are manufactured in compliance with prescribed usage limits and their usage standards, It was manufactured in compliance with cosmetic safety standards. Both of the cosmetic compositions thus prepared were stored at room temperature where no direct sunlight could reach them, and clinical trials were carried out.

Evaluation of efficacy of cosmetic composition for lips

The subjects were selected to conduct clinical trials to confirm the effectiveness of the cosmetic composition. Based on the "Guideline for Evaluation of Functional Cosmetics for Effective Evaluation of Functional Cosmetics to Help Improve Wrinkles," published by Korea Food and Drug Administration, 2005.07, Experimental group and control group were constructed to obtain valid data.

More specifically, among adult males and females aged 30 to 59 years old, 1) the examinee's naked lower lip wrinkles are confirmed, and 2) the subject who is not exposed to keratin is fully explained 3) to be healthy without any acute or chronic physical illness including skin disease, 4) to have a wrinkle on the test site at the discretion of the state tester, and 5) Were selected for follow - up. Then, through interviews with selected people, 1) you are pregnant or breastfeeding or are pregnant, 2) you have been using a skin contour containing steroids for at least 1 month to treat skin disease, or 3) Or 4) there is a skin abnormality such as dots, acne, erythema and capillary dilatation on the test site, or 5) the same or similar cosmetics or medicines are used in the test site within 3 months before the start of the study Or 6) have received a resurfacing or wrinkle removal procedure within 6 months prior to the start of the study, or 7) those who are considered unsuitable for the test at the discretion of the other state investigator. In addition, even if the subject does not meet the criteria for exclusion and does not meet the criteria for selection, he or she may be affected by: 1) an adverse reaction such as fever or erythema on the test site; or 2) 3) it is difficult for the subject to follow up due to personal circumstances during the course of the experiment, or 4) it is judged that the test is difficult to continue due to the judgment of the other testee People were treated as dropouts and excluded from valid data.

Not only did all of the above-mentioned subjects be consented to participation in clinical trials prior to testing, but also obtained the consent of the subjects in accordance with the "Guidelines for Testing and Validating Cosmetics for Human Subjects, 2015" published by the Food and Drug Administration I have faithfully communicated all the information I ought to provide.

As a result, the final validity data for 204 subjects were obtained.

Total number of subjects 204 gender M: 0 person / woman: 204 people Average age 42.5 years Age distribution 30s 68 people 40s 96 50s 40 people

<Test Method>

end. EXAMPLES Cosmetic compositions and methods of applying cosmetic compositions of comparative examples

In order to prevent the contents of the sample from being known to both the tester and the subject, the cosmetic material of the embodiment and the cosmetic material of the comparative example were placed in the same container, and the sample code used for classification was sealed so as not to be exposed, Were distributed to the subjects. The subjects were self-administered with appropriate amounts of the cosmetic composition of Example or Comparative Example twice daily, under the supervision of the tester.

I. The lip wrinkle evaluation means

Various methods of clinical evaluation of wrinkle functional cosmetics are known in Korea and internationally. In addition to visual evaluation by experts, the Korea Food & Drug Administration has developed an indirect device evaluation method for measuring wrinkles by making replica, , And in this clinical trial, the device evaluation using a replica analyzer (Visiometer SV600) and an image analyzer (ANTERA 3D TM), and a visual evaluation by an expert Wrinkle improvement effect was evaluated. Using a skin-visiometer SV600 (CK electronic GmbH, Germany), a device capable of analyzing skin surface wrinkles using silicone repilica, By analyzing the shade, the result was calculated for each of the following items R1 to R3.

R1 - Skin Roughness

R2 - Maximum Roughness

R3 - Average Roughness

All. Test sequence

1) First Visit

After using the standard cleanser provided by the tester, it was patted with a paper towel to remove water. After 30 minutes of constant temperature and humidity (20 ~ 24 ℃, 40 ~ 60% RH) Stability was taken.

The photographs of the lower lip center folds and Antera 3D were taken, and 2 experienced experts including dermatologists evaluated the wrinkles by 0-9 scale (0: no wrinkles, 9: wrinkles) When the scores of the two evaluation sites were different, higher values were adopted.

The wrinkle analysis was performed using the visiometer at the center of the lower lip and the fabricated area of the silicon wool used for the wrinkle analysis was as follows: a) Horizontal axis: the horizontal center of the vertical line; b) vertical axis: the center of the vertical axis of the virtual line; c) The point at which the horizontal and vertical axes meet is taken as 0; d) The most flat and smooth surface of the rectangular temple area made by the process of a) and b) is selected and marked at the middle point; e) Determine the distance from the zero point to the horizontal axis and the vertical axis, and make them available for the next measurement.

In order to prevent the contents of the sample from being known to both the tester and the tester, the sample cosmetics and the comparative cosmetics were distributed in the same container, and the sample code used for the classification was sealed so as not to be exposed, A). A 'cosmetics' and 'a' cosmetics were randomly assigned to the subjects, and after the subjects were instructed on the precautions and product usage of the subjects, the allocated samples were distributed. During the test period, compliance with product use was checked daily by telephone.

In addition, a prepared swab was handed to each subject, and a swab which was rolled once at the application site was submitted immediately after applying the lip cosmetic composition.

2) Second visit (4th use) / 3rd visit (8th use)

After using the standard cleanser provided by the tester, it was patted with a paper towel to remove water. After 30 minutes of constant temperature and humidity (20 ~ 24 ℃, 40 ~ 60% RH) Stability was taken.

The photographs of the lower lip and Antera 3D were taken in the same manner as the first visit. In addition, a dermatologist's visual evaluation and evaluation of erythema, edema, scaling, itching, stinging, burning, tightness, prickling, And other abnormal symptoms were judged.

3) Fourth visit (last visit, use 12th week)

After using the standard cleanser provided by the tester, it was patted with a paper towel to remove water. After 30 minutes of constant temperature and humidity (20 ~ 24 ℃, 40 ~ 60% RH) Stability was taken.

Photographs of the lower lip center folds and Antera 3D were taken, and a visual evaluation was performed by a dermatologist.

After wrinkle analysis using a visiometer at the center of the lower lip, the dermatologist assessed the adverse reaction. The roughness analysis of the silicon wafers was carried out on the last visit on which all silicon wafers were fabricated to reduce measurement errors.

<Result>

end. Antera 3D measurement results

Referring to Table 4 below, the degree of reduction of the Antera 3D measurement value (Indentation index, wrinkles small) shows a wrinkle reduction effect in both the cosmetic compositions of the examples and the comparative examples. In the case of the cosmetic compositions of the examples, .

On the other hand, Comparative Examples 8 to 11 showed wrinkle improvement rates similar to those of the example cosmetics. However, even though the cosmetic ingredients were added more than the examples, they did not exhibit the high effect as the addition amount.

I. Expert's visual evaluation result

Referring to Table 5 below, it was confirmed that the cosmetic composition of the present invention had an average wrinkle index value of 1 point or more after 12 weeks. It is found that the use of more than 12 weeks shows significant results in the improvement of wrinkles.

On the other hand, in the case of Comparative Examples 1 to 7, it was confirmed that the degree of wrinkle improvement after the first 4th week was not much different from the degree of wrinkle improvement after the 12th week, It can be seen that it has an improvement effect even in long-term use.

In the case of the cosmetic compositions of Comparative Examples 8 to 11, it was confirmed that the degree of wrinkle reduction was similar or somewhat lower than that of the Example of the present invention after the 12th week of operation, which was judged to be an effect obtained by adding an active ingredient to the wrinkle excessively. However, in comparison with the cosmetic compositions of the Examples, it was confirmed that even though the active ingredient was further added, when the active ingredient was added beyond the marginal potency, additional effects were not obtained.

All. Skin-Visiometer SV600 measurement result

The values of R1, R2, and R3 tend to decrease as the number of days of use of the cosmetic composition increases. However, in the case of the cosmetic composition of the embodiment, it can be seen that each parking lot tends to decrease significantly compared to the comparative cosmetic composition.

In the case of Comparative Examples 8 to 11, it can be confirmed that only an effect similar or equivalent to that of the cosmetic composition of the Example is shown, as compared with the case where an excessive amount of the active ingredient is added.

la. Whether a skin disorder occurs during the clinical trial

In the case of the cosmetic preparations of Examples and Comparative Examples 1 to 7, no abnormal abnormalities were found to the subjects during the above-mentioned clinical trial period.

However, in the case of the cosmetic preparation of Comparative Example 8, about twelve subjects felt the itching and / or stiffness of the lips skin, and in Comparative Examples 9 to 11, It was confirmed that there were symptoms of erythema or swelling.

hemp. Estimation of Cosmetic Durability

The persistence was evaluated by dividing into three groups according to the amount of cosmetics on the collected swabs.

According to Table 10, in Examples 2 to 4, the durability was excellent, and the comparative cosmetics were found to have generally low durability. In the case of Example 1, the holding power was lower than those of Examples 2 to 4, and in the case of the comparative examples in which the added amount was exceeded, the holding power was very low.

From the above test results, tocopheryl acetate, dipalmitoyl hydroxyproline, ceramide endophyte, and panthenol can act as active ingredients to improve the wrinkles of the lips, respectively, but when used together, It can be used as a cosmetic having particularly excellent effects when it is used for a long period of time without any special abnormal symptoms in the human body.

Furthermore, when the polyglyceryl-2 isostearate / dimer dilinoleate copolymer and dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate are further added in an appropriate amount, The sustained action of the active ingredient can be improved and the active ingredient can be effectively applied to the lips skin.

Claims (11)

A cosmetic composition for the improvement of lip wrinkles comprising Tocopheryl Acetate, Dipalmitoyl Hydroxyproline, Ceramide and Panthenol,
Wherein the cosmetic composition comprises 0.1 to 10% by weight of tocopheryl acetate, 0.001 to 1% by weight of dipalmitoyl hydroxyproline, 0.001 to 1% by weight of ceramide, and 0.001 to 1% by weight of panthenol based on the total weight of the cosmetic composition Gt; cosmetic composition for improving &lt; / RTI &gt; delete The method according to claim 1,
Characterized in that it comprises 0.5 to 8% by weight of tocopheryl acetate, 0.005 to 0.1% by weight of dipalmitoyl hydroxyproline, 0.005 to 0.1% by weight of ceramide and 0.005 to 0.1% by weight of panthenol based on the total weight of the cosmetic composition A cosmetic composition for improving the wrinkles of the lips. The method according to claim 1,
The ceramide may be selected from the group consisting of ceramide 1 (EOS), ceramide 2 (NS), ceramide 3 (NP), ceramide 4 (EOH), ceramide 5 (AS), ceramide 6 (NH), ceramide 7 And ceramide 9 (EOP). The method according to claim 1,
Wherein the cosmetic composition further comprises a skin softening polymer. 6. The method of claim 5,
The skin softening polymer may be selected from the group consisting of dipentaerythritol hexahydroxystearate / hexa stearate / hexa rogninate, dipentaerythritol tri-polyhydroxystearate, polyglyceryl-2 isostearate / dimer dilinoleate ko At least one member selected from the group consisting of polymer, hydrogenated castor oil dimer dilinoleate, polyglyceryl-10 nonisostearate, and phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate &Lt; / RTI &gt; The method according to claim 6,
Wherein the skin softening polymer is dipentaerythritol hexahydroxystearate / hexa stearate / hexa rosinate and / or polyglyceryl-2 isostearate / dimer dilinoleate copolymer. 8. The method of claim 7,
Wherein said dipentaerythritol hexahydroxystearate / hexa stearate / hexa rognate is present in an amount of 0.01 to 3% by weight based on the total weight of the cosmetic composition. 8. The method of claim 7,
Wherein the polyglyceryl-2 isostearate / dimer dilinoleate copolymer is present in an amount of 0.01 to 3% by weight based on the total weight of the cosmetic composition. The method according to claim 1,
The cosmetic composition may contain at least one selected from the group consisting of fatty substances, organic solvents, solubilizers, thickening and gelling agents, softening agents, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic emulsifiers, Wherein the cosmetic composition further comprises at least one adjuvant selected from the group consisting of ionic sequestering agents and chelating agents, preservatives, vitamins, organic sunscreens, wetting agents, oils, dyes, pigments, hydrophilic or lipophilic active agents and lipid vesicles. 11. The method according to any one of claims 1 and 3 to 10,
Wherein the cosmetic composition is manufactured from one of the group consisting of lipgloss, lip balm, lip balm, lip treatment and lipstick.

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