CN1720891A - Enzyme-containing toothpaste and its preparing process - Google Patents
Enzyme-containing toothpaste and its preparing process Download PDFInfo
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- CN1720891A CN1720891A CN 200510035023 CN200510035023A CN1720891A CN 1720891 A CN1720891 A CN 1720891A CN 200510035023 CN200510035023 CN 200510035023 CN 200510035023 A CN200510035023 A CN 200510035023A CN 1720891 A CN1720891 A CN 1720891A
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Abstract
The invention discloses an enzyme-containing toothpaste and its preparing process, wherein the toothpaste is prepared from solid antalzyme and acetic acid (including edible vinegar and glacial acetic acid) as the raw material, as well as toothpaste grease matrix constituents including wetting agent, binding agent, blowing agent, polishing ingredient, sweetener, perfume compound and deionized water. The toothpaste has an external appearance of transparent or non-transparent grease, and a taste of light sour acid, the toothpaste can prevent and treat the common dental and oral diseases including periodontitis, periodontitis, tooth hemorrhage, teeth allergy, foul breath and peculiar smell in oral cavity.
Description
Technical field
The present invention relates to a kind of toothpaste, refer in particular to a kind of enzyme-containing toothpaste.
Background technology
Toothpaste is as daily living article, and health care, cleaning are its basic functions.Toothpaste is through the differentiation of decades, by single functional shift for having multiple functions such as nursing, reparation, health care, anti-inflammation and sterilization, auxiliary treatment.Along with development of biology, the biological enzyme toothpaste development is very fast in recent years.And the rapid progress of enzyme engineering research also makes the development of enzyme engineering industry very fast, becomes one of new industry of 21 century.How toothpaste manufacturing enterprise utilizes this technology, is new problems to us.
Biological enzyme toothpaste is to add biological enzyme formulation in formulation of tooth-paste, and by the cell wall of noxious bacteria in the enzyme dissolving orally, the effect of bacteriostasis and sterilization is played in the metabolism that influences antibacterial, thereby takes care of one's teeth, and increases the prevention system in oral cavity self.
Yet the stability of bioenzyme activity is its key problem in technology in the toothpaste applied research.One of characteristics of enzyme are poor stabilities.Various factors all might make enzyme forfeiture biologos as physical factor (temperature, pressure and light), chemical factor (pH, electrolyte, ionic strength, oxidation and reduction) and the factor of production (enzymatic degradation) etc.Toothpaste is complicated mixture.According to the effect of each component in toothpaste, raw material of toothpaste is divided into: wetting agent, binding agent, foaming agent, abrasivus, sweeting agent, essence and deionized water etc.These raw materials have liquid phase and solid phase with regard to its form, liquid phase has the branch of water and oil phase again.Therefore, should keep biological enzyme activity in the toothpaste, guarantee the stability of lotion of toothpaste again, this is the problem that enzyme must be studied in toothpaste is used.
Also have, under the prerequisite of taking into account the tooth paste product quality, it also is very important giving a kind of novel unique taste of toothpaste simultaneously.For example commercially available bamboo salt toothpaste because of it contains the composition of salt, so it not only has the effect of anti-inflammation and sterilization, and has salty special taste, is subjected to the welcome and the approval of consumer now gradually.
In view of this, provide the special toothpaste of a kind of taste that can keep enzyme activity can guarantee mastic stability again real for necessary.
Summary of the invention
Main purpose of the present invention is to provide a kind of enzyme-containing toothpaste with antiphlogistic antibacterial effect.
Another object of the present invention is to provide a kind of enzyme activity to keep persistent enzyme-containing toothpaste.
Another object of the present invention is to provide a kind of taste special enzyme-containing toothpaste.
Another object of the present invention is to provide a kind of manufacture method of enzyme-containing toothpaste.
For achieving the above object, a kind of enzyme-containing toothpaste of the present invention comprises lotion of toothpaste matrix components and lysozyme.In one embodiment, described enzyme-containing toothpaste further comprises acetic acid.The percentage by weight of described lysozyme in described enzyme-containing toothpaste is 0.01～0.1%.The percentage by weight (in acetic acid content) of described acetic acid in described enzyme-containing toothpaste is 0.1～1.0%.In one embodiment, the enzyme product vigor of described lysozyme is more than or equal to 2.0 ten thousand u/mg.The percentage by weight of described lysozyme in described enzyme-containing toothpaste is 0.07～0.1%; The percentage by weight of described acetic acid in described enzyme-containing toothpaste is 0.1～0.5%.In one embodiment, described lotion of toothpaste matrix components comprises wetting agent, binding agent, foaming agent, abrasivus, sweeting agent, essence and deionized water.The percentage by weight of described each component of lotion of toothpaste matrix components is:
Wetting agent 20～70%
Binding agent 0.5～2.5%
Foaming agent 1.0～3.0%
Abrasivus 15～50%
Sweeting agent 0.1～0.3%
Essence 0.8～1.5%
Deionized water 5～43%
The manufacture method of a kind of enzyme-containing toothpaste of the present invention comprises the steps:
A deionized water dissolving lysozyme of/10th to 1/50th with Total Water;
With surplus deionized water dissolving sweeting agent, add the aqueous solution of acetic acid and lysozyme then, and drop into together in the system cream container,
Add wetting agent, binding agent, abrasivus, foaming agent, and open scraper plate and agitator;
Drop into essence after stirring very first time section, restir got final product after second time period.
In one embodiment, the percentage by weight of described lysozyme in described enzyme-containing toothpaste is 0.01～0.1%; The percentage by weight (in acetic acid content) of described acetic acid in described enzyme-containing toothpaste is 0.1～1.0%; Described very first time section is 10-30 minute, and described second time period is 5-15 minute.
In the present invention, owing to adopted lysozyme, so it has tangible antibacterial functions to gram positive bacteria; And added acetic acid, and institute is so that enzyme-containing toothpaste good stability of the present invention, and it is lasting that enzyme activity keeps, and for example still has 80% vigor after 2 years.Because lysozyme is more stable under the meta-acid condition, make the mastic slant acidity so in toothpaste, add acetic acid, can prolong the shelf life of lysozyme toothpaste; In addition, add the function that acetic acid can further be strengthened anti-inflammation and sterilization, and safety has no side effect.Simultaneously, enzyme-containing toothpaste of the present invention has the effect of antiinflammatory, desensitization, preventing decayed tooth, antihalitosis and removing smoke spots, and taste is novel unique, has the acetic acid flavor slightly, uses the back clean taste comfortable.
The specific embodiment
A kind of enzyme-containing toothpaste of the present invention comprises lotion of toothpaste matrix components and lysozyme and acetic acid.Wherein to account for the percentage ratio of lotion of toothpaste gross weight be 0.01～0.1% to lysozyme.Described lysozyme (Lysozyme) is to adopt biotechnology, regulates albumen pH value and spent ion exchange resin adsorbing separation and gets.Molecular weight is 14307, it is a kind of glycoside hydrolase, can dissolve the cell wall of gram positive bacteria, and it there is stronger killing action, also can be used for the crystalline protein lysozyme formulation, prevent food spoilage, in food fresh keeping (particularly cheese, rice wine production), medicine (tablet, capsule, collyrium, liquid wets one's whistle), daily use chemicals (toothpaste, cosmetics), baby food (humanized milk powder) and scientific research, have a wide range of applications.Described lysozyme is white crystal or powder, alkaline protein, isoelectric pH 10.5-11.0.Lysozyme product vigor 〉=2.0 ten thousand u/mg is dissolved in weak brine, generates precipitation under acetone and ethanol effect, and acid solution is more stable, is heated to 55 ℃ and also can be affected, and its aqueous solution is at 62.5 ℃, and 30 minutes can complete deactivation.And its alcoholic solution of 15% is at 62.5 ℃, can inactivation in 60 minutes yet, and 20.5% alcoholic solution is at 62.5 ℃, also non-inactivation in 20 minutes.This lysozyme solubilized bacterial cell, particularly micrococcus is had and pretend usefulness, various character with antibiotics, this is because the polysaccharide of the glycoprotein (mucoid) of its pair cell membranous wall, has decomposition, chitin and ethylene glycol chitin be can decompose, carbonate, hydrochlorate and nitrate crystallization etc. obtained.Its service condition is: 35 ℃ of optimum temperatures, pH value are 4.0-6.5.
Because lysozyme is more stable under the meta-acid condition, so enzyme-containing toothpaste of the present invention adds an amount of acetic acid.The acetic acid colourless transparent liquid, its percentage ratio that accounts for the lotion of toothpaste gross weight is 0.1～1.0% in acetic acid content.Described acetic acid is to adopt fine tablet vinegar or glacial acetic acid.The vinegar edible, safety has no side effect, and people are to its anti-inflammation and sterilization and the function of anti-flu, and also right and wrong Changshu is known.Contain the effect that vinegar toothpaste has antiinflammatory, desensitization, preventing decayed tooth, antihalitosis and removing smoke spots.Bacteriostatic test shows that containing vinegar toothpaste has tangible antibacterial functions to cariogenic bacteria and periodontal pathogen.
In the present invention, described lotion of toothpaste matrix components comprises wetting agent, binding agent, foaming agent, abrasive, sweeting agent, essence and the balance of deionized water of mixing composition by a certain percentage.In the present invention, described wetting agent can be glycerol, sorbitol, propylene glycol, diethylene glycol or Polyethylene Glycol.Described several wetting agent can be singly with also can being several being used in combination.Described binding agent can be sodium carboxymethyl cellulose, hydroxyethyl-cellulose, carrageenan or HANSHENGJIAO.Described several binding agent can singly be used, and also can severally be used in combination.Described foaming agent is generally sodium lauryl sulphate.Described abrasivus is calcium carbonate, calcium hydrogen phosphate or silicon dioxide.Described several abrasivus can be singly with or several being used in combination.In the present invention, the outward appearance of this enzyme-containing toothpaste is transparent or opaque mastic.
Further the present invention is set forth below in conjunction with several specific embodiments.
Embodiment 1
The shared total weight percent of each component of enzyme-containing toothpaste described in the present embodiment is: lysozyme 0.01%, acetic acid 0.1%, glycerol 10%, sorbitol 15%, sodium carboxymethyl cellulose 1.4%, sodium lauryl sulphate 1%, calcium carbonate 47%, glucide 0.25%, essence 1.0%, deionized water surplus;
Its manufacture method is: dissolve lysozyme with proper amount of deionized water earlier, and standby; After using surplus deionized water dissolving glucide then, add the aqueous solution of acetic acid and lysozyme, drop into together subsequently in the system cream pot, pump into glycerol and sorbitol, stir; Suck calcium carbonate, sodium lauryl sulphate, sodium carboxymethyl cellulose then, drive scraper plate and agitator; Drop into essence after 20 minutes; Restir discharging in 10 minutes.
Embodiment 2
The shared total weight percent of each component of enzyme-containing toothpaste described in the present embodiment is: lysozyme 0.05%, acetic acid 0.3%, sorbitol 30%, sodium carboxymethyl cellulose 0.9%, hydroxyethyl-cellulose 0.4%, sodium lauryl sulphate 1.5%, calcium hydrogen phosphate 42%, glucide 0.25%, essence 1.0%, deionized water surplus.
Example example 3
The shared total weight percent of each component of enzyme-containing toothpaste described in the present embodiment is: lysozyme 0.07%, acetic acid 0.5%, Polyethylene Glycol 10%, sorbitol 15%, sodium carboxymethyl cellulose 1.0%, HANSHENGJIAO 0.3%, sodium lauryl sulphate 2.0%, calcium hydrogen phosphate 35%, silica 1 0%, glucide 0.21%, essence 1.0%, deionized water surplus.
Embodiment 4
The shared total weight percent of each component of enzyme-containing toothpaste described in the present embodiment is: lysozyme 0.07%, acetic acid 0.7%, diethylene glycol 5%, propylene glycol 10%, sorbitol 15%, sodium carboxymethyl cellulose 0.9%, carrageenan 0.4%, sodium lauryl sulphate 2.5%, calcium carbonate 25%, silica 1 5%, glucide 0.22%, essence 1.0%, the deionized water surplus.
Embodiment 5
The shared total weight percent of each component of enzyme-containing toothpaste described in the present embodiment is: lysozyme 0.1%, acetic acid 1.0%, sorbitol 70%, sodium carboxymethyl cellulose 1.4%, sodium lauryl sulphate 3.0%, silica 1 8%, glucide 0.25%, essence 1.0% and balance of deionized water.
In the present invention, the manufacture method of described embodiment 2～5 is: dissolve lysozyme with proper amount of deionized water earlier, and standby; Behind surplus deionized water dissolving glucide, add the aqueous solution of acetic acid and lysozyme, drop into together then in the system cream pot, pump into wetting agent (be glycerol, or sorbitol, propylene glycol, diethylene glycol, Polyethylene Glycol), stir; Suck abrasivus (being calcium carbonate or calcium hydrogen phosphate, silicon dioxide), foaming agent (sodium lauryl sulphate) and binding agent (being sodium carboxymethyl cellulose or hydroxyethyl-cellulose, carrageenan, HANSHENGJIAO) then, drive scraper plate and agitator; Drop into essence after 20 minutes; Restir discharging in 10 minutes.
Above disclosed is the preferred embodiment of enzyme-containing toothpaste of the present invention and manufacture method thereof only, can not limit the present invention's interest field certainly with this, and therefore the equivalent variations of being done according to the present patent application claim still belongs to the scope that the present invention is contained.
Claims (10)
1. an enzyme-containing toothpaste comprises the lotion of toothpaste matrix components, it is characterized in that: described enzyme-containing toothpaste also comprises lysozyme.
2. a kind of enzyme-containing toothpaste as claimed in claim 1 is characterized in that further comprising acetic acid.
3. enzyme-containing toothpaste as claimed in claim 1 or 2 is characterized in that the percentage by weight of described lysozyme in described enzyme-containing toothpaste is 0.01～0.1%.
4. enzyme-containing toothpaste as claimed in claim 3 is characterized in that the percentage by weight (in acetic acid content) of described acetic acid in described enzyme-containing toothpaste is 0.1～1.0%.
5. enzyme-containing toothpaste as claimed in claim 3 is characterized in that: the enzyme product vigor of described lysozyme is more than or equal to 2.0 ten thousand u/mg.
6. enzyme-containing toothpaste as claimed in claim 4 is characterized in that: the percentage by weight of described lysozyme in described enzyme-containing toothpaste is 0.07～0.1%; The percentage by weight of described acetic acid in described enzyme-containing toothpaste is 0.1～0.5%.
7. enzyme-containing toothpaste as claimed in claim 1 or 2 is characterized in that: described lotion of toothpaste matrix components comprises wetting agent, binding agent, foaming agent, abrasivus, sweeting agent, essence and deionized water.
8. enzyme-containing toothpaste as claimed in claim 7 is characterized in that: the percentage by weight of described each component of lotion of toothpaste matrix components is:
Wetting agent 20～70%
Binding agent 0.5～2.5%
Foaming agent 1.0～3.0%
Abrasivus 15～50%
Sweeting agent 0.1～0.3%
Essence 0.8～1.5%
Deionized water 5～43%
9. the manufacture method of an enzyme-containing toothpaste is characterized in that comprising the steps:
A deionized water dissolving lysozyme of/10th to 1/50th with Total Water;
With surplus deionized water dissolving sweeting agent, add the aqueous solution of acetic acid and lysozyme then, and drop into together in the system cream container,
Add wetting agent, binding agent, abrasivus, foaming agent, and open scraper plate and agitator;
Drop into essence after stirring very first time section, restir got final product after second time period.
10. the manufacture method of enzyme-containing toothpaste as claimed in claim 9, it is characterized in that: the percentage by weight of described lysozyme in described enzyme-containing toothpaste is 0.01～0.1%; The percentage by weight (in acetic acid content) of described acetic acid in described enzyme-containing toothpaste is 0.1～1.0%; Described very first time section is 10-30 minute, and described second time period is 5-15 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100350237A CN100361645C (en) | 2005-06-06 | 2005-06-06 | Enzyme-containing toothpaste and its preparing process |
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| CNB2005100350237A CN100361645C (en) | 2005-06-06 | 2005-06-06 | Enzyme-containing toothpaste and its preparing process |
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| Publication Number | Publication Date |
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| CN1720891A true CN1720891A (en) | 2006-01-18 |
| CN100361645C CN100361645C (en) | 2008-01-16 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100417373C (en) * | 2006-05-26 | 2008-09-10 | 清华大学 | Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof |
| CN104739719A (en) * | 2015-03-06 | 2015-07-01 | 吉林省现代中药工程研究中心有限公司 | Toothpaste capable of quickly relieving pain, diminishing inflammation, inhibiting bacteria, preventing dental caries and freshening breath |
| CN105902400A (en) * | 2016-06-17 | 2016-08-31 | 江山 | Biological enzyme-coated particle and preparation method and application thereof |
| CN105943408A (en) * | 2016-06-07 | 2016-09-21 | 上海舒雅心日用品有限公司 | Fluoride-free anti-infection toothpaste with natural sterilization effect and preparation method thereof |
| CN106265238A (en) * | 2016-08-17 | 2017-01-04 | 林少英 | A kind of toothpaste removing tobacco dirty remover |
| CN106619179A (en) * | 2016-12-20 | 2017-05-10 | 泰州比尔夫生物科技有限公司 | Toothpaste capable of preventing and treating dental ulcers |
| CN107411999A (en) * | 2017-07-20 | 2017-12-01 | 重庆夫日用品有限责任公司 | A kind of tooth-caring toothpaste and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2747570B1 (en) * | 1996-04-19 | 1998-07-24 | Dogself | ANTI-SCALE COMPOSITION AND ITS USE IN ANIMAL FEED SUPPLEMENTS |
| CN1175398A (en) * | 1996-09-04 | 1998-03-11 | 四川奇人牙膏有限责任公司 | Toothpaste containing acetic acid |
| MY114945A (en) * | 1997-04-24 | 2003-02-28 | Sunstar Inc | Oral composition |
| CN1075371C (en) * | 1998-03-06 | 2001-11-28 | 曹家鑫 | Enzyme added tooth paste and preparing method thereof |
-
2005
- 2005-06-06 CN CNB2005100350237A patent/CN100361645C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100417373C (en) * | 2006-05-26 | 2008-09-10 | 清华大学 | Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof |
| CN104739719A (en) * | 2015-03-06 | 2015-07-01 | 吉林省现代中药工程研究中心有限公司 | Toothpaste capable of quickly relieving pain, diminishing inflammation, inhibiting bacteria, preventing dental caries and freshening breath |
| CN105943408A (en) * | 2016-06-07 | 2016-09-21 | 上海舒雅心日用品有限公司 | Fluoride-free anti-infection toothpaste with natural sterilization effect and preparation method thereof |
| CN105902400A (en) * | 2016-06-17 | 2016-08-31 | 江山 | Biological enzyme-coated particle and preparation method and application thereof |
| CN105902400B (en) * | 2016-06-17 | 2019-10-11 | 四川百奥可生物科技有限责任公司 | A kind of particle and its preparation method and application of wrapping biological enzyme |
| CN106265238A (en) * | 2016-08-17 | 2017-01-04 | 林少英 | A kind of toothpaste removing tobacco dirty remover |
| CN106619179A (en) * | 2016-12-20 | 2017-05-10 | 泰州比尔夫生物科技有限公司 | Toothpaste capable of preventing and treating dental ulcers |
| CN107411999A (en) * | 2017-07-20 | 2017-12-01 | 重庆夫日用品有限责任公司 | A kind of tooth-caring toothpaste and preparation method thereof |
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| CN100361645C (en) | 2008-01-16 |
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Granted publication date: 20080116 Termination date: 20100606 |