CN104739719A - Toothpaste capable of quickly relieving pain, diminishing inflammation, inhibiting bacteria, preventing dental caries and freshening breath - Google Patents

Abstract

The invention discloses toothpaste capable of quickly relieving pain, diminishing inflammation, inhibiting bacteria, preventing dental caries and freshening breath. The toothpaste body of the commercial toothpaste contains ampelopsis grossedentata ethanol extract, streptococcus mutans IgY and lysozyme, wherein the ampelopsis grossedentata ethanol extract accounts for 0.5-5.0% of the weight of the toothpaste body, the streptococcus mutans IgY accounts for 0.05-0.5% of the weight of the toothpaste body, and the lysozyme accounts for 0.05-0.5% of the weight of the toothpaste body. The toothpaste has the advantages: the added ampelopsis grossedentata ethanol extract can quickly relieve toothache within a few minutes, so the pain relieving effect is obvious; the added streptococcus mutans IgY and the lysozyme are both extracted from egg, so the toothpaste is natural in source and does not have side effect; the toothpaste can effectively prevent dental caries and maintain ecological balance of oral floras; the lysozyme plays a role in stopping bleeding, relieving swelling and pain and accelerating tissue recovery; and the compatible three can exert self effects and cooperate with one another to enhance the effects.

Description

The toothpaste of the rapid pain relieving of a kind of energy, antiinflammatory, antibacterial, anti-caries, fresh breath

Technical field

The invention belongs to health field, be specifically related to a kind of toothpaste.

Background technology

Toothpaste is indispensable oral cavity cleaning hygienic article in people's daily life, and the basic function of toothpaste is cleaning teeth, fresh breath, reaches the object keeping oral cavity cleaning.In recent years, because consumer healthcare realizes continuous enhancing, more requirement is proposed to toothpaste, as pain relieving, whitening, hemostasis, antiinflammatory etc.Take Western medicine as the toothpaste of functional component, have rapid-action, the advantage of Be very effective, but due to source, security problems, the visual field of people of having faded out gradually.The advantage that Chinese medicine has natural, safety grade for Western medicine is incomparable, and be rich in folk prescription or the compound toothpaste of Chinese medicine extract, exist again and take effect slowly, can not comparatively fast alleviate the problems such as dental pain symptom.

Summary of the invention

The object of this invention is to provide a kind of can pain relieving rapidly, have antiinflammatory, antibacterial concurrently, caries prevention, the toothpaste of cleaning implication, overcomes existing medicated toothpaste above shortcomings.

Toothpaste of the present invention includes Ampelopsis grossedentata ethanol extraction, Streptococcus mutans IgY, lysozyme in the mastic of commercial toothpaste variety; Wherein, Ampelopsis grossedentata ethanol extraction accounts for 0.5 ~ 5.0% of lotion of toothpaste weight, and Streptococcus mutans IgY accounts for 0.05 ~ 0.5% of lotion of toothpaste weight, and lysozyme accounts for 0.05 ~ 0.5% of lotion of toothpaste weight.

The present invention be based on:

1, Ampelopsis grossedentata (formal name used at school: Ampelopsis grossedentata) is the plant of Vitaceae Ampelopsis, also known as Ampelopsis grossedentata, Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz., Chinese bush cherry tea, black liana (certain kind of berries), canine tooth Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae), field mother-in-law's tea, red Radix seu Herba Tetrastigmatis Hypoglauci etc., be the endemic plant of China, be distributed in the ground such as the Jiangxi of China's Mainland, Guangdong, Guizhou, Hunan, Hubei, Fujian, Yunnan, Guangxi.Herb is medicinal, sweet in the mouth, light, cool in nature, has effect of heat-clearing and toxic substances removing, wind-damp dispelling, bone and muscle strengthening, is usually used in the diseases such as treatment cold, fever, laryngopharynx swelling and pain, icterohepatitis, acute conjunctivitis, carbuncle scabies, hypertension.In the pharmacopeia such as " rescuing motherwort book on Chinese herbal medicine ", " national Chinese herbal medicine compilation ", have clear and definite record, Ampelopsis grossedentata color green bloom, drinking effect has obvious health protection and therapeutic action, once has the title of " Ramulus et Folium Mussaendae Pubescentis ", " refreshing tea " in history.The chemistry of recent year external Ampelopsis grossedentata platymiscium, pharmacology, the aspect such as clinical have carried out large quantifier elimination, demonstrate the effect that this genus and extract thereof have antiviral, antibacterial, anti-inflammatory and antalgic.

2, when making bird inlay adaptive immune with some antigen, chicken can produce corresponding serum antibody, and by the mode of laying eggs, antibody is vertically entailed offspring and be stored in egg yolk.Namely chicken produces corresponding immunoglobulin, and transports, is stored in the yolk of ovum gallinaceum.Owing to only having IgG antibody-like in Ovum Gallus domesticus Flavus, therefore claim its " Yolk immune globulin IgG, writes a Chinese character in simplified form IgY) ".Streptococcus mutans IgY is with Streptococcus mutans (Sreeptococcusmutans) Immune Laying Hens, the antibody extracted from egg yolk.It has special binding ability to Streptococcus mutans, the potent suppression Streptococcus mutans of its energy, and then suppresses the formation of dental plaque, reaches the object of effective preventing decayed tooth.Its safety, nontoxic, have no side effect, other bacterium of normally lodging in oral cavity can not be killed, affect the ecological balance of oral cavity flora.The oral cavity ecological environment that the decayed tooth antibacterial that it is formed cannot produce, can produce lasting specific action.

3, lysozyme (Lysozyme) is also known as muramidase (Muramidase), is a kind of alkaline enzyme that can be hydrolyzed mucopolysaccharide in pathogenic bacterium.Mainly through destroying the β-Isosorbide-5-Nitrae glycosidic bond of N-acetylmuramic acid in cell wall and N-n acetylglucosamine n quality inspection, making the insoluble mucopolysaccharide of cell wall resolve into solubility glycopeptide, causing cell wall rupture content overflow and make bacterolysis.Lysozyme also directly can be combined with electronegative virus protein, forms double salt, make virally inactivated with DNA, RNA, apoprotein.Lysozyme can be used as a kind of natural infection material with bactericidal action, has antibacterial, antiviral, hemostasis, reducing swelling and alleviating pain and accelerates the effects such as organized renewing function.

Good effect of the present invention is;

1, Ampelopsis grossedentata is often oral is used for the treatment of the disease such as cold, fever, laryngopharynx swelling and pain.Conventional Ampelopsis grossedentata among the people is when tea-drinking control oral inflammation.Ampelopsis grossedentata is applied in toothpaste first time by the present invention, plays the effect such as anti-inflammatory analgesic, fresh breath.In order to strengthen product effect, the extractum of Ampelopsis grossedentata of the present invention after ethanol extraction adds in toothpaste, through verification experimental verification, with the addition of the toothpaste of Ampelopsis grossedentata, can alleviate toothache rapidly within three minutes.

2, Streptococcus mutans IgY and lysozyme all extract from egg, originate natural, the product non-chemically synthesized.Safety, nontoxic, have no side effect.Wherein adding of Streptococcus mutans IgY can effective caries prevention, maintains the ecological balance of oral cavity flora.Lysozyme plays a role in hemostasis, reducing swelling and alleviating pain, quickening organized renewing function.Three's compatibility can play the effect of self, but mutually works in coordination with, auxiliary reinforced effects.

Compliance test result

Toothpaste of the present invention is carried out extracorporeal bacteria inhibitor test, the therapeutical effect of tentative gingivitis is tested, the therapeutical effect of tentative gingivitis is tested, analgesic activity is tested (patient with toothache viewing test), tested the impact in mice docking bleeding time, show that toothpaste of the present invention has inhibitory action in various degree to the antibacterial that the oral cavity infections such as staphylococcus aureus, staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans are common, to tentative gingivitis, there is obvious therapeutical effect, there is obvious anastalsis, through patient with toothache test, can pain relieving rapidly.The results are shown in following table.

Table 1

By the present invention and commercially available a kind of containing Flos Lonicerae, Flos Chrysanthemi Indici, the toothpaste declaring to have anti-inflammatory analgetic function alleviates the toothache time, effective percentage is had a toothache in alleviation, tentative gingivitis effective percentage three aspects carry out comparing, result is all better than commercially available prod, and concrete outcome sees the following form.

Table 2

Detailed description of the invention

1, Ampelopsis grossedentata extracts using 50% ethanol as solvent, and it is for subsequent use after the clear paste of 1.08 that extracting solution is concentrated into relative density.

2, according to the form below provides 4 embodiments of different content.Wherein in each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage

Embodiment explanation

1, the wetting agent (sorbitol in embodiment 1,2 in above-described embodiment, sorbitol in embodiment 3 and propylene glycol, propylene glycol in embodiment 4), the binding agent (sodium carboxymethyl cellulose in embodiment 1, embodiment 2 sodium carboxymethyl cellulose, carrageenan, Konjac glucomannan and carrageenan in embodiment 3, the sodium carboxymethyl cellulose in embodiment 4, Konjac glucomannan), Ampelopsis grossedentata clear paste, sweeting agent (saccharin sodium) and water makes glue.

2, above-mentioned glue liquid material delivery pump is delivered in vacuum cream tank, add abrasivus (calcium hydrogen phosphate of embodiment 1 and the silicon dioxide through measuring, the calcium hydrogen phosphate of embodiment 2, the calcium pyrophosphate of embodiment 3 and silicon dioxide, embodiment 4 calcium pyrophosphate), foaming agent (sodium laurylsulfate in embodiment), solid small powder (the antitypy streptococcus IgY in embodiment and lysozyme), antiseptic (sodium benzoate) carries out stirring, homogenizing.

3, after the vacuum of vacuum Manufacturing medicine extract machine reaches requirement, drop into the tea essence measured in advance, continue to stir homogenizing.

4, after homogenizing degassed several minutes, after paste density reaches requirement, cream processed completed, and adopted automatically cannedly to have packed with packer.

Claims (1)

1. a toothpaste for the rapid pain relieving of energy, antiinflammatory, antibacterial, anti-caries, fresh breath, is characterized in that: include Ampelopsis grossedentata ethanol extraction, Streptococcus mutans IgY, lysozyme in lotion of toothpaste; Wherein, Ampelopsis grossedentata ethanol extraction accounts for 0.5 ~ 5.0% of lotion of toothpaste weight, and Streptococcus mutans IgY accounts for 0.05 ~ 0.5% of lotion of toothpaste weight, and lysozyme accounts for 0.05 ~ 0.5% of lotion of toothpaste weight.