CN104491840A - Oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and preparation thereof - Google Patents
Oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and preparation thereof Download PDFInfo
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- CN104491840A CN104491840A CN201410843153.2A CN201410843153A CN104491840A CN 104491840 A CN104491840 A CN 104491840A CN 201410843153 A CN201410843153 A CN 201410843153A CN 104491840 A CN104491840 A CN 104491840A
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Abstract
The invention discloses an oral medicine composition for resisting radiation, preventing dental caries and diminishing inflammation and a preparation thereof, and belongs to the technical field of oral medicine preparations. The composition is prepared from the following components in parts by mass: 100-500 parts of white hyacinth bean extract, 100-2000 parts of grape seed proanthocyanidin extract, 300-3000 parts of tea polyphenol, 0.01-0.1 part of epidermal growth factor EGF, 10-200 parts of triclosan and 2-6 parts of ammonium hexafluorosilicate. The oral medicine composition and the preparation thereof disclosed by the invention have a durable antibacterial effect, can be attached to the surface of teeth or oral cavity for a long time to form a protective film, can be used for tenderly protecting the oral cavity, has an excellent taste, and is safe to human bodies.
Description
Technical field
The invention belongs to oral medicine preparation technical field, be specifically related to mouth cavity medicine compositions and the preparation thereof of the antiinflammatory of a kind of radioprotective preventing decayed tooth.
Background technology
Not only can there is early stage acute effect at that time at exposure in human body, and just occurring remote effect even for more time by according to after the several years after being subject to the effects of ionizing radiation of doses.To the hydrone in human body cell and biomolecule, the effect as protein has the meaning of particular importance in ionizing radiation, wherein hydrone ionization and excite (ionization and excitation) to produce free radical, and free radical is the main cause of the radiation injury causing organic molecule.In addition, ionizing radiation can cause cell division to postpone (division delay) change and cell death.The biological effect produced by radiation comprises direct effect (direct action) and indirect action (indirect action).Direct effect is that radiation self or its offspring generated directly act on the effect that molecule causes.Such as use x-ray bombardment organism, after energy being given to certain secondary electron, this electronics reproduces into the free of target molecule, produce active free radical (free radical), this free radical chemical property is very active, be bonded to the atom in organism beyond hydrogen atom, namely may cause the degeneration of institute's binding molecule, and then produce biological effect.The offspring that indirect action is radiation self or is generated by it, first act on medium molecule (such as hydrone), make it to become the active product of chemical property (such as free radical, hydrogen peroxide, aqueous electron etc.), this product continues the effect acting on molecule formation again.Indirect action raying sensitive agent (radiosensitizer) or radiation protective (radioprotector) can strengthen or weaken, direct effect then not malleable.The cell injury caused divides 3 classes: (1) fatal injury (lethal damage) is irreversible causes cell death; (2) sublethal damage (sublethal damage) is repaired in several hours under normal circumstances; (3) PLD (potentially lethal damage), damage under certain condition can be repaired.Reparation after ionizing radiation team cell injury can divide 3 levels: the reparation of (1) tissue level, and namely int cell is replanted in the tissue; (2) cellular level reparation, namely owing to changing the environmental condition or segmentation of irradiating rear cell, the survival of cell is increased; (3) reparation of molecular level, namely makes the DNA molecular of damaged regain one's integrity by the effect of desmoenzyme system.
The main ray of Irradiation mucositis is caused to be x-ray, β line and γ line.X, β line penetration capacity is strong, and except mucosa, sub-mucosal tissues, body of gland, even skeleton is also impaired, sometimes produces ulcer and does not heal for a long time.β line loss wound is shallow, and easily, as long as process proper, prognosis is better most in treatment.In addition, the absorbed dose produced needed for identical mucosa injury are different.γ line loss hinders mucosal absorption dosage comparatively greatly, and β line is then less.Because the penetration capacity of γ line is strong, ionization is little, and the energy passing to mucosa is also little, and portion of energy consumption is at deep tissues.And the ionization of β line is strong, the energy of mucosal absorption is also many.There is quite a few X or γ line mucosa injury to be associated with radiation illness, make observation and treat more difficult.The clinical manifestation of chronic radioactive mucosa injury: have longer incubation period, the state of an illness has the features such as obvious potentiality, Progressive symmetric erythrokeratodermia, repeatability and persistence.Patients with radioactive mucositis of oral cavity is initially oral mucosa redness, and occur the expansion of blood capillary reactivity subsequently, contrafluxion, erythema, erosion, ulcer, pseudomembrane cover, and severe patient merges the extensive atrophy of mucosa and local infection.Normal sense oral mucosa discomfort, xerostomia, halitosis, even continue pain unbearably.Lonizing radiation except coup injury oral mucosa, and make the blood capillary generation swelling in radiation open country, tube wall thickening, and tube chamber narrows or obturation, occurs damaged part blood supply insufficiency, and oral mucositis occurs.Xerostomia is that the salivary gland based on the parotid gland occurs acinus and catheter injury for a long time after shining, and cause secretory volume to reduce, salivary component changes thereupon, and oral environment changes and dysbacteriosis.Internal environment of oral cavity change makes to reduce bacterial defenses ability, and the bacterial reproduction such as Streptococcus mutans and lactobacillus causes dental caries to occur, and even occurs large area acute radiation dental caries.There is demineralization phenomenon in the normal tooth neck portion enamel after raying simultaneously, enamel stove micropore increases, deepen and the appearance in enamel crack, make the antibacterial in oral cavity and acidic materials enter enamel inside along enamel defects, and acid-resisting declines, accelerate the development process that dental caries damage, cause rampant caries.The overall principle of current Clinical Processing is puted prevention first, mitigation symptoms, Promotive union, control concurrent infection.Adopt topical anti-inflammatory, sterilization and analgesic to treat for patients with radioactive mucositis of oral cavity is clinically more and alleviates, but the reparation of simple anti-inflammation to mucosa does not have positive effect, and radiation causes immunity of organisms to reduce, often increasing the weight of symptom because merging other infection, affecting wound healing.
Showing morbidity of dental caries according to Stomatologic Medical College, No.4 Military Medicine Univ. to general population's oral epidemiology survey result is 38.6%, and gingivitis periodontal disease sickness rate is 59%, and oral mucositis sickness rate is 4.7%, and oral cavity and throat is scorching, xerostomia sickness rate is almost 0.And the same period is according to the clinical cross-sectional investigation result display to more than 500 name relevant staff oral epidemiologies, molecular epidemiology: radioactivity morbidity of dental caries is 97.4%, gingivitis periodontal disease sickness rate is 82%, patients with radioactive mucositis of oral cavity sickness rate reaches 53.6%, radioactivity oral cavity and throat inflammation is 27%, and radioactivity xerostomia sickness rate is up to 87%.By statistical data, can find out that the oral diseases such as relevant staff's dental caries, oral mucositis are occurred frequently, part disease incidence is even high than general population average attack rate tens times.Analyze under paathogenic factor mainly contains and be in direct or indirect ionization radiation irradiation condition for a long time, environment is closed, and oral disease is usually associated with the secondary infection of the funguses such as Candida albicans, herpes simplex virus, anaerobe, antibacterial and virus.The grievous injury of radiation simultaneously whole body body function, causes immunity of organism, defence reparation function degradation, the course of disease is delayed, recurrent exerbation.Bring great body and mind painful to relevant staff, have a strong impact on their routine work and emergency.To decline about 20%-30% according to the preclinical cross-sectional investigation statistical estimation rate of attendance.
Medicine at present for radioactivity oral disease is generally symptomatic treatment, and curative effect is not good enough, has certain toxic and side effects, lacks specific aim and portability, is not suitable for the prophylactic treatment under emergency condition.
Summary of the invention
In order to overcome the defect that above-mentioned prior art exists, the object of the present invention is to provide mouth cavity medicine compositions and the preparation thereof of the antiinflammatory of a kind of radioprotective preventing decayed tooth.
The present invention is achieved through the following technical solutions:
The mouth cavity medicine compositions of a kind of radioprotective preventing decayed tooth antiinflammatory, in mass fraction, comprise the Semen Lablab Album extract of 100 ~ 500 parts, the grape pip procyanidin extract of 100 ~ 2000 parts, the tea polyphenols of 300 ~ 3000 parts, the epidermal growth factor EGF of 0.01 ~ 0.1 part, the ammonium hexafluorosilicate of the DP300 of 10 ~ 200 parts and 2 ~ 6 parts.
With this mouth cavity medicine compositions for effective ingredient, add that collutory made by adjuvant, speed collapses gargle tablet, effervescent tablet or spray.
Described adjuvant is one or more in freshener, sweeting agent, plasticizer, disintegrating agent, freshener and stabilizing agent.
Radioprotective preventing decayed tooth anti-inflammation gargle water, in mass fraction, comprises the Semen Lablab Album extract of 100 parts, the grape pip procyanidin extract of 100 parts, the tea polyphenols of 300 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 20 parts, the ammonium hexafluorosilicate of 2 parts, 10 parts of mass fractions are the pilocarpine of 2%, the lignocaine of 100 parts, the Mentholum of 100 parts, the sorbitol of 100 parts, the sweeting agent of 100 parts, the distilled water of the edible essence of 100 parts and 9130 parts.
Radioprotective preventing decayed tooth antiinflammatory speed collapses gargle tablet, in mass fraction, comprises the Semen Lablab Album extract of 300 parts, the grape pip procyanidin extract of 500 parts, the tea polyphenols of 500 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 100 parts, the ammonium hexafluorosilicate of 2 parts, the soluble starch of 500 parts, the mannitol of 5750 parts, the PVP K30 of 900 parts, the controlled micro crystallization cellulose of 1500 parts, the polyvinylpolypyrrolidone XL-10 of 500 parts, the dipeptide sweetener of 50 parts, the Mentholum of 200 parts, the edible essence of 10 parts.
Radioprotective preventing decayed tooth antiinflammatory effervescent tablet, in mass fraction, comprises the Semen Lablab Album extract of 300 parts, the grape pip procyanidin extract of 1000 parts, the tea polyphenols of 1000 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 100 parts, the ammonium hexafluorosilicate of 2 parts, the soluble starch of 500 parts, the sodium bicarbonate of 4200 parts, the citric acid of 2800 parts, the dipeptide sweetener of 10 parts, the hydroxypropyl cellulose of 14 parts, 10 parts of polyethylene glycol 6000s, the edible essence of the Mentholum of 100 parts and 10 parts.
The agent of radioprotective preventing decayed tooth antiinflammatory concentrated spray, in mass fraction, comprise the Semen Lablab Album extract of 500 parts, the grape pip procyanidin extract of 1000 parts, the tea polyphenols of 1000 parts, the epidermal growth factor of 0.1 part, the DP300 of 200 parts, the ammonium hexafluorosilicate of 2 parts, the sorbitol of 1000 parts, the potassium carbonate of 100 parts, the sodium chloride of 100 parts, the mass fraction of 100 parts is the pilocarpine of 0.2%, the lignocaine of 200 parts, the Mentholum of 200 parts, the sweeting agent of 10 parts, the distilled water of the edible essence of 10 parts and 5550 parts.
Compared with prior art, the present invention has following useful technique effect:
The mouth cavity medicine compositions of radioprotective preventing decayed tooth of the present invention antiinflammatory, effective ingredient comprises Semen Lablab Album extract, grape pip procyanidin extract, tea polyphenols, epidermal growth factor EGF, DP300 and ammonium hexafluorosilicate.This mouth cavity medicine compositions is for the serious ionizing radiation oral disease such as oral mucositis, pharyngolaryngitis, xerostomia, acute dental caries, periodontal disease, cheilitis extensively existed, analyse in depth its main pathogenic of screening, use combination of Chinese and Western medicine principle, select various effective ingredient, composition mouth cavity medicine compositions.The advantage of each composition is as follows:
1, Semen Lablab Album extract has special regulating and controlling effect to histiocyte, the damage that can alleviate or stop extrinsic factor to cause, the radioprotective mucosa injury medicine of the multiple dosage form being active fraction preparation with it all has good curative effect, is used on mucosa and has powerful radiation resistance.Simultaneously it also has antibacterial, antiviral, the lymphocytic activity of enhancing T, improves the effects such as the immunologic function of cell.
2, grape pip procyanidin extract has extremely strong antioxidation and Free-radical scavenging activity, the antioxidation that current occurring in nature finds, the material that Scavenging ability is the strongest, its antioxidant activity is 50 times, ascorbic 20 times of the plain E of dimension, it can effectively remove free radical unnecessary in human body, has superpower antiinflammatory radioprotective and the effect of enhancing immunity.
3, tea polyphenols Absorbable rod radioactive substance, stop it at human body internal diffusion, there is removing toxic substances and radiation resistance, radioactive substance can be effectively stoped to invade bone marrow, and radioactive substance can be made to excrete rapidly, tea polyphenols also has extremely strong radical scavenging activity, blocks lipid peroxidation process, improve the activity of human enzymes, the effective inhibitory action alleviated ray and medullary cell is increased weight; Tea polyphenols can kill the effect that the Streptococcus mutans, lactobacillus etc. that exist in slot have suppression glucose polymerisation enzymatic activity simultaneously, glucose can not be polymerized at bacterium table, make the process interrupt that dental caries is formed, preventing decayed tooth teeth consolidating, tea polyphenols can also kill the Putrefying bacteria in food debris, removes halitosis.
4, epithelical cell growth factor EGF can not only promote the histiocytic propagation of skin mucosa and growth, newborn cell is made to replace rapidly old and feeble and dead cell, and the DNA in promotion oral mucosa, RNA, the cross-cell membrane motion of protein and extracellular Macromolecular synthesis and small-molecule substance, improve the protection of mucosa cells and tissue inherence, repair and immunologic function, promote that oral mucosa wound surface cell RNA and DNA's copies the synthesis with protein, the basis of tissue regeneration and reparation is provided, shorten wound healing time, anti-inflammatory analgetic control oral mucositis, also certain preventive and therapeutic effect is had to gingival hemorrhage.
5, DP300 is gentle nonionic long-acting antibiotic agent, is exclusively used in dental care product, chemistry trichlorohydroxyl phenylate by name.It can remove oral cavity residue and harmful microorganism more up hill and dale; anti-inflammation and sterilization effect is particularly remarkable; not only to causing gingivitis, the pathogenic bacterium of periodontitis have efficient inhibitory or killing effect; also dental plaque can be assisted in removing; prevention of gingivitis, dental caries etc.; keep oral environment health, clean, free from extraneous odour; eliminate dentin hypersensitiveness, there is after using durable antibiotic effect, tooth or oral surfaces can be attached to for a long time; form protecting film; gentle care oral cavity, and good mouthfeel, without Liver and kidney metabolism; directly excrete, to human-body safety.
6, ammonium hexafluorosilicate can promote the formation of silicon dioxide calcium phosphate, play the effect of stronger blocking dentinal tubule, and the resistivity of tooth to acid can also be strengthened, dentin ferrule is reduced, thus play stronger anti-sensitization, there is good Effect of Dental Tubule Seal After.Simultaneously coordinate antibacterials with the use of, obvious synergistic function can be reached, tooth antiallergic effect is strengthened, there is good anticaries action simultaneously.
Simultaneously, the present invention adopt modern advanced biologics technology of preparing be relevant staff's oral health develop a series of to put prevention first, the radioprotective preventing decayed tooth antiinflammatory series oral pharmaceutical product of easy to carry, auxiliary treatment, comprise radioprotective preventing decayed tooth anti-inflammation gargle water, radioprotective preventing decayed tooth antiinflammatory speed collapse gargle tablet, radioprotective preventing decayed tooth antiinflammatory effervescent tablet and the agent of radioprotective preventing decayed tooth antiinflammatory concentrated spray, prophylactic treatment relevant staff oral disease.Wherein radioprotective preventing decayed tooth anti-inflammation gargle water is mainly used in relevant staff and carries out common oral disease prevention health care.Radioprotective preventing decayed tooth antiinflammatory speed collapses when gargle tablet is mainly used in emergent protects individual radioactivity oral disease.Concentrate when radioprotective preventing decayed tooth antiinflammatory effervescent tablet is then mainly used in emergent and exchange for colony.The agent of radioprotective preventing decayed tooth antiinflammatory concentrated spray is mainly equipped with in emergency circumstances tackles acute radiation oral disease.This medicine series, from ordinary times and emergent two kinds of different conditions, carries out drug development targetedly from prevention and therapy two aspects, can every safeguard work of adaptive radiation disease oral disease comprehensively.This is to healthy the having important practical significance of protection hospital radiological department relevant staff.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
The mouth cavity medicine compositions of radioprotective preventing decayed tooth of the present invention antiinflammatory, based on radioprotective preventing decayed tooth antiinflammatory primary activity composition, the primary activity composition of pharmaceutical composition provided by the present invention is Semen Lablab Album extract, grape pip procyanidin extract, tea polyphenols, epidermal growth factor EGF, DP300 and ammonium hexafluorosilicate.
The component of this primary activity Composition Weight Parts ratio is: in mass fraction, comprise the Semen Lablab Album extract of 100 ~ 500 parts, the grape pip procyanidin extract of 100 ~ 2000 parts, the tea polyphenols of 300 ~ 3000 parts, the epidermal growth factor EGF of 0.01 ~ 0.1 part, the ammonium hexafluorosilicate of the DP300 of 10 ~ 200 parts and 2 ~ 6 parts.
Raw material sources of the present invention are as follows:
Title: Semen Lablab Album extract; Producer: Xi'an Bioisystech Co., Ltd of Tianrui; The place of production: Xi'an article No.: TR148; Specification: 10:1; Effective ingredient: containing protein, sucrose, glucose, maltose, stachyose (stachyose), Raffinose (raffinose), L-pipecolic acid (L-pipecilic acid), phytohemagglutinin (phytoagglutinin) etc.
Title: grape pip procyanidin extract; Producer: Xi'an Bioisystech Co., Ltd of Tianrui; The place of production: Xi'an; Article No.: TR127; Specification: polyphenol 40%, 60%, 80%; Procyanidin 98%; Effective ingredient: procyanidin, polyphenol;
Title: tea polyphenols.Producer: Xi'an Bioisystech Co., Ltd of Tianrui; The place of production: Xi'an; Article No.: TR1162; Specification: 100; Effective ingredient: catechin, anthocyanidin, combine in a group polyphenol complex in Folium Camelliae sinensis with class and phenolic acids etc.;
Title: epidermal growth factor (EGF); Producer: offshore protein Science and Technology Ltd.; The place of production: Shanghai offshore; Article No.: C029; Specification: 10 μ g/50 μ g/1mg; Effective ingredient: recombinant human epidermal growth factor, epidermal growth factor, hEGF.
Title: DP300; Producer: Hui Feng medication chemistry company limited; The place of production: Handan, Hebei; Article No.: CAS3380-34-5; Specification: 25 kilograms of fiber cans; Chloro-2 hydroxyls-two of effective ingredient: 2,4,4'-tri-
Title: ammonium hexafluorosilicate; Producer: Ren Qing Chemical trade company limited of Wenzhou City; The place of production: Wenzhou District of Zhejiang Province; Article No.: CAS16919-19-0; Specification: 25 kilograms of fiber cans; Effective ingredient: fluorine silication ammonium, ammonium silicofluoride, ammonium hexafluorosilicate.
Radioprotective preventing decayed tooth antiinflammatory series oral disease prophylactic treatment preparation of the present invention can be made into multiple dosage form, as radioprotective preventing decayed tooth anti-inflammation gargle water, radioprotective preventing decayed tooth antiinflammatory speed collapse gargle tablet, radioprotective preventing decayed tooth antiinflammatory effervescent tablet, the agent of radioprotective preventing decayed tooth antiinflammatory concentrated spray etc.The medicine of above-mentioned various dosage form all can be prepared according to the conventional method of pharmaceutical field.According to the needs of different dosage form, one or more ancillary drugs, freshener, emulsifying agent, disintegrating agent, sweeting agent, plasticizer and pigment etc. can also be added in said medicine.The addition of described dosage form can adjust according to practical situation.
Radioprotective preventing decayed tooth antiinflammatory preparation series of the present invention can not only effectively remove free radical unnecessary in human body, the radiation damage that extrinsic factor causes can be blocked, there is superpower radiation resistance, and promote that oral mucosa wound surface cell RNA and DNA's copies the synthesis with protein, the basis of tissue regeneration and reparation is provided, shorten wound healing time, anti-inflammatory analgetic control oral mucositis.Simultaneously; efficiently can also kill the dental caries pathogenic bacterium such as Streptococcus mutans, remove dental plaque preventing decayed tooth teeth consolidating, block gingivitis, periodontitis pathogenic process; keep oral hygiene, free from extraneous odour; eliminate dentin hypersensitiveness, there is after using durable antibiotic effect, tooth or oral surfaces can be attached to for a long time; form protecting film; gentle care oral cavity, and good mouthfeel, to human-body safety.
Embodiment 1
Radioprotective preventing decayed tooth anti-inflammation gargle water, in mass fraction, comprises the Semen Lablab Album extract of 100 parts, the grape pip procyanidin extract of 100 parts, the tea polyphenols of 300 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 20 parts, the ammonium hexafluorosilicate of 2 parts, 10 parts of mass fractions are the pilocarpine of 2%, the lignocaine of 100 parts, the Mentholum of 100 parts, the sorbitol of 100 parts, the sweeting agent of 100 parts, the distilled water of the edible essence of 100 parts and 9130 parts.
The preparation method of radioprotective preventing decayed tooth anti-inflammation gargle water is as follows: in aseptic production department, by Semen Lablab Album extract, grape pip procyanidin extract, tea polyphenols, epidermal growth factor EGF, DP300, ammonium hexafluorosilicate, 0.2% pilocarpine, sorbitol and lignocaine, add in clean glass container successively in above ratio, stir gently, after abundant mix homogeneously, add the Mentholum of described ratio again, sweeting agent, sorbitol, edible essence and distilled water homogeneous mixture, after all mixture are fully mixed, detect qualified rear fill and seal warehouse-in in sterile plastic bottle, room temperature preservation.
The using method of this radioprotective preventing decayed tooth anti-inflammation gargle water is gargled after directly opening, and consumption is 1-3 times/day, 200ml/ time, rinsing the mouth 3 minutes.In the present embodiment, described collutory finished product from the appearance homogeneous mixture solotion, is generally white; On taste, sugariness is moderate, not bitter, ice-cold; Total number of bacteria: <100/L; Escherichia coli: <30/L; Pathogenic bacterium: must not detect.
Embodiment 2
Radioprotective preventing decayed tooth antiinflammatory speed collapses gargle tablet, in mass fraction, comprises the Semen Lablab Album extract of 300 parts, the grape pip procyanidin extract of 500 parts, the tea polyphenols of 500 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 100 parts, the ammonium hexafluorosilicate of 2 parts, the soluble starch of 500 parts, the mannitol of 5750 parts, the PVP K30 of 900 parts, the controlled micro crystallization cellulose of 1500 parts, the polyvinylpolypyrrolidone XL-10 of 500 parts, the dipeptide sweetener of 50 parts, the Mentholum of 200 parts, the edible essence of 10 parts.
The preparation method that this radioprotective preventing decayed tooth antiinflammatory speed collapses gargle tablet is as follows: divide another name Semen Lablab Album extract, grape pip procyanidin extract, tea polyphenols, epidermal growth factor EGF, DP300, ammonium hexafluorosilicate, mannitol to add in clean glass container by above prescription, stir gently, after abundant mix homogeneously, add stabilizing agent soluble starch, composition speed collapses the active ingredient units of gargle tablet.Add PVP K30 solution again, stir, cross 40 mesh sieves and granulate, dry.Be scattered in by residue other materials in controlled micro crystallization cellulose PROSOLVSMCC 50, mix with above-mentioned granule, with the stamping of 13mm shallow arc circle, tablet hardness controls at 4kgf.Detect qualified rear package encapsulation warehouse-in, room temperature preservation.
The using method that this radioprotective preventing decayed tooth antiinflammatory speed collapses gargle tablet is: with a small amount of water directly rinsing the mouth in oral cavity, and tablet is disintegrate dispersion in 30 seconds, and form the suspension containing fine particle, the rapid stripping of active component, safeguards oral health.Also after can first making it dissolve with a small amount of water in oral cavity rinsing the mouth.Consumption is 1-3 time/sheet, 1 piece/times, rinsing the mouth 3 minutes.In the present invention, described gargle tablet finished product is from the appearance even, glossy, is generally white; On taste, sugariness is moderate, not bitter, ice-cold; Total number of bacteria: <100/Kg; Escherichia coli: <30/Kg; Pathogenic bacterium: must not detect.
Embodiment 3
Radioprotective preventing decayed tooth antiinflammatory effervescent tablet, in mass fraction, comprises the Semen Lablab Album extract of 300 parts, the grape pip procyanidin extract of 1000 parts, the tea polyphenols of 1000 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 100 parts, the ammonium hexafluorosilicate of 2 parts, the soluble starch of 500 parts, the sodium bicarbonate of 4200 parts, the citric acid of 2800 parts, the dipeptide sweetener of 10 parts, the hydroxypropyl cellulose of 14 parts, 10 parts of polyethylene glycol 6000s, the edible essence of the Mentholum of 100 parts and 10 parts.
The preparation method of this radioprotective preventing decayed tooth antiinflammatory effervescent tablet is as follows: by dipeptide sweetener and sodium bicarbonate Homogeneous phase mixing, crosses 16 mesh sieves, dry at 50 DEG C; Separately get hydroxypropyl cellulose and add the moistening dispersion of ethanol, then add appropriate distilled water and make it to expand into serosity; Get a part citric acid, add above-mentioned hydroxypropyl cellulose binding agent, make soft material, cross 16 mesh sieves and obtain granule, dry at 50 DEG C; After the Semen Lablab Album extract taken in proportion, grape pip procyanidin extract, tea polyphenols, epidermal growth factor EGF, DP300, ammonium hexafluorosilicate and stabilizing agent soluble starch are mixed, add polyethylene glycol 6000 again, Mentholum, edible essence to add in clean glass container fully after mix homogeneously, mix with the dry thing of above-mentioned sodium bicarbonate and citric acid again, cross 18 mesh sieves, with the stamping of 13mm shallow arc circle, tablet hardness controls at 4kgf.Detect qualified after pack warehouse-in, room temperature preservation.
The using method of this radioprotective preventing decayed tooth antiinflammatory effervescent tablet is: in the ratio of 1: 200mL clear water, will render in water and decomposed completely in 5 minutes, gargles after forming mouthwash solution.Individual doses is 1-3 time/sheet, 1 piece/times, rinsing the mouth 3 minutes.When collective uses, above dosage adds up per capita.In the present embodiment, described effervescent tablet finished product is from the appearance even, glossy, is generally white; On taste, sugariness is moderate, not bitter, ice-cold; Total number of bacteria: <100/Kg; Escherichia coli: <30/Kg; Pathogenic bacterium: must not detect.
Embodiment 4
The agent of radioprotective preventing decayed tooth antiinflammatory concentrated spray, in mass fraction, comprise the Semen Lablab Album extract of 500 parts, the grape pip procyanidin extract of 1000 parts, the tea polyphenols of 1000 parts, the epidermal growth factor of 0.1 part, the DP300 of 200 parts, the ammonium hexafluorosilicate of 2 parts, the sorbitol of 1000 parts, the potassium carbonate of 100 parts, the sodium chloride of 100 parts, the mass fraction of 100 parts is the pilocarpine of 0.2%, the lignocaine of 200 parts, the Mentholum of 200 parts, the sweeting agent of 10 parts, the distilled water of the edible essence of 10 parts and 5550 parts.
The preparation method of this radioprotective preventing decayed tooth antiinflammatory concentrated spray agent is as follows: in aseptic production department, by Semen Lablab Album extract, grape pip procyanidin extract, tea polyphenols, epidermal growth factor EGF, DP300, ammonium hexafluorosilicate, 0.2% pilocarpine, sorbitol, lignocaine, potassium phosphate and sodium chloride, add in clean glass container successively in above ratio, stir gently, after abundant mix homogeneously, add the Mentholum of shown ratio again, sweeting agent, edible essence, distilled water homogeneous mixture, after all mixture are fully mixed, be input into holding vessel, store 2 hours, filter, fill 50mL plastic mist spray bottle, sealing, packaging, be finished product after the assay was approved.Room temperature preservation.
The using method of this radioprotective preventing decayed tooth antiinflammatory concentrated spray agent is: be sprayed on affected part after directly opening, consumption is 1-3 times/day, and 1-2ml/ time, the course for the treatment of is generally 3-20 days, and dosage and the course for the treatment of all can to follow the doctor's advice adjustment according to practical situation.Also can by 5ml solution: 200ml clear water converts into collutory, rinsing the mouth 3 minutes is for oral cavity health at ordinary times.In the present invention, described concentrated spray agent finished product from the appearance Homogeneous phase mixing suspension solution, is generally white; On taste, sugariness is moderate, not bitter, ice-cold; Total number of bacteria: <100/100ml; Escherichia coli: <30/100ml; Pathogenic bacterium: must not detect.
The index of correlation of the product that embodiments of the invention obtain meets following list regulation: table 1 is organoleptic indicator and physical and chemical index; Table 2 is cleaning agent for mouth cavity sanitary index
Table 1
Table 2
In sum, the present invention is by long-term basic research, extensive investigations sampling, deep drug screening, the mouth cavity medicine compositions medicine series of radioprotective preventing decayed tooth antiinflammatory is proposed hereby, be provided in hospital radiological department staff at ordinary times in prevention and health care medicine-chest or emergent medicine-chest to tackle the radioactivity oral disease of relevant staff.This medicine series comprises following primary activity composition:
Semen Lablab Album extract: Semen Lablab Album is a kind of conventional Chinese medicine is the seed of leguminous plant Dolichos lablab; Semen Lablab Album begins to be loaded in " Mingyi Bielu ", and all there is cultivation all parts of the country, the ground such as main product Zhejiang, Anhui, Hunan, Henan.Semen Lablab Album is that excellent thing of holding concurrently eaten by medicine, nutritious, containing compositions such as fatty oil, protein, nicotinic acid, aminoacid, vitamin and saccharides, also containing trace element and calcium, phosphorus, ferrum etc., with seed, seed coat, flower hyoscine or edible.Semen Lablab Album sweet in the mouth, light, property is put down, and clinical practice is very extensive.Semen Lablab Album extract has special regulating and controlling effect to histiocyte, the damage that can alleviate or stop extrinsic factor to cause, the radioprotective mucosa injury medicine of the multiple dosage form being active fraction preparation with it all has good curative effect, is used on mucosa and has powerful radiation resistance.Simultaneously it also has antibacterial, antiviral, the lymphocytic activity of enhancing T, improves the effects such as the immunologic function of cell.
Grape pip procyanidin extract (OPC): be pulverized by Semen Vitis viniferae drying, after Kernel-hull separation, with ethanol carry out extracting in shell, filter, spraying dry obtains just extract, first extract through solvent staging or active carbon adsorption dry bronzing powder.Domestic and international many research finds that it has multiple important biomolecule activity and pharmacological action, there are extremely strong antioxidation and Free-radical scavenging activity, the antioxidation that current occurring in nature finds, the material that Scavenging ability is the strongest, its antioxidant activity is 50 times, ascorbic 20 times of the plain E of dimension, it can effectively remove free radical unnecessary in human body, has superpower antiinflammatory radioprotective and the effect of enhancing immunity.Germ experiment and animal experiment study find that grape pip procyanidin extract has inhibitory action to Streptococcus mutans, to the generation of activity in vivo oxygen and active nitrogen, and the appreciable impact of expression on the inducible nitric oxide synthase that periodontal disease macrophage lipopolysaccharide intensifies.Therefore, grape pip procyanidin extract can effectively kill Streptococcus mutans preventing decayed tooth, by affecting the progress prevention of periodontal disease of periodontitis.
Tea polyphenols (TP): the general name being Polyphenols of Tea, comprises flavanol compound, anthocyanin class, flavonoid, flavonols and phenolic acids etc.Japan moved to tea district and lived from the person confronted by danger after hiroshima bomb blast and drink a large amount of excellent green tea the 1950's, not only still survived, and the discovery of this factfinding of euthesia, and tea is a kind of radiation antidote.Tea polyphenols has excellent radiation-resisting functional, and tea polyphenols Absorbable rod radioactive substance, stops it at human body internal diffusion, be called as natural filter device.The removing toxic substances of tea polyphenols isoreactivity material tool and radiation resistance, effectively can stop radioactive substance to invade bone marrow, and radioactive substance can be made to excrete rapidly, be described as " radiation jinx " by healthy and medical circle.Tea polyphenols also has extremely strong radical scavenging activity, blocks lipid peroxidation process, improves the activity of human enzymes, the effective inhibitory action alleviated ray and increase weight to medullary cell.Tea polyphenols can kill the Streptococcus mutans, lactobacillus etc. that exist in slot simultaneously, has the effect suppressing glucose polymerisation enzymatic activity, glucose can not be polymerized at bacterium table, make the process interrupt that dental caries is formed, preventing decayed tooth teeth consolidating.Tea polyphenols can also kill the Putrefying bacteria in food debris, removes halitosis.
Epithelical cell growth factor EGF: be a kind of be extensively present in people Skin Cell, milk, saliva, gastric juice, the biologically active polypeptide be made up of 53 aminoacid in kidney and cerebral tissue, there is very strong biological effect.Research shows: the EGF of denier can intense stimulus Growth of Cells.EGF can not only promote the histiocytic propagation of skin mucosa and growth, newborn young cell is made to replace rapidly old and feeble and dead cell, and the DNA in promotion oral mucosa, RNA, the cross-cell membrane motion of protein and extracellular Macromolecular synthesis and small-molecule substance, improve the protection of mucosa cells and tissue inherence, repair and immunologic function, promote that oral mucosa wound surface cell RNA and DNA's copies the synthesis with protein, the basis of tissue regeneration and reparation is provided, shorten wound healing time, anti-inflammatory analgetic control oral mucositis, also certain preventive and therapeutic effect is had to gingival hemorrhage.
DP300 is gentle nonionic long-acting antibiotic agent, is exclusively used in dental care product, chemistry trichlorohydroxyl phenylate by name.It can remove oral cavity residue and harmful microorganism more up hill and dale, anti-inflammation and sterilization effect is particularly remarkable, not only to causing gingivitis, the pathogenic bacterium of periodontitis have efficient inhibitory or killing effect, also dental plaque can be assisted in removing, prevention of gingivitis, dental caries etc., keep oral environment healthy, totally, free from extraneous odour, eliminate dentin hypersensitiveness, there is after using durable antibiotic effect, tooth or oral surfaces can be attached to for a long time, form protecting film, gentle care oral cavity, and good mouthfeel, without Liver and kidney metabolism, directly excrete, to human-body safety, the most popular in the world at present, the antibacterial anti-inflammatory agent that state-of-the-art New-type wide-spectrum is efficiently non-stimulated.Through American-European and Ge great multinational corporations extensive life-time service in decades, prove DP300 to the mankind and environment very safe, be widely used in the dental care product such as toothpaste, collutory in recent years.
Ammonium hexafluorosilicate: chemical formula (NH
4)
2siF
6, be abbreviated as SiF.Ammonium hexafluorosilicate can promote the formation of silicon dioxide calcium phosphate, play the effect of stronger blocking dentinal tubule, and the resistivity of tooth to acid can also be strengthened, dentin ferrule is reduced, thus play stronger anti-sensitization, there is good Effect of Dental Tubule Seal After.Simultaneously coordinate antibacterials with the use of, obvious synergistic function can be reached, tooth antiallergic effect is strengthened, there is good anticaries action simultaneously.
Claims (7)
1. the mouth cavity medicine compositions of radioprotective preventing decayed tooth antiinflammatory, it is characterized in that, in mass fraction, comprise the Semen Lablab Album extract of 100 ~ 500 parts, the grape pip procyanidin extract of 100 ~ 2000 parts, the tea polyphenols of 300 ~ 3000 parts, the epidermal growth factor EGF of 0.01 ~ 0.1 part, the ammonium hexafluorosilicate of the DP300 of 10 ~ 200 parts and 2 ~ 6 parts.
2. the mouth cavity medicine compositions of radioprotective preventing decayed tooth according to claim 1 antiinflammatory, is characterized in that, with this mouth cavity medicine compositions for effective ingredient, adds that collutory made by adjuvant, speed collapses gargle tablet, effervescent tablet or spray.
3. the mouth cavity medicine compositions of radioprotective preventing decayed tooth according to claim 2 antiinflammatory, is characterized in that, described adjuvant is one or more in freshener, sweeting agent, plasticizer, disintegrating agent, freshener and stabilizing agent.
4. based on the radioprotective preventing decayed tooth anti-inflammation gargle water of the mouth cavity medicine compositions of radioprotective preventing decayed tooth according to claim 1 antiinflammatory, it is characterized in that, in mass fraction, comprise the Semen Lablab Album extract of 100 parts, the grape pip procyanidin extract of 100 parts, the tea polyphenols of 300 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 20 parts, the ammonium hexafluorosilicate of 2 parts, 10 parts of mass fractions are the pilocarpine of 2%, the lignocaine of 100 parts, the Mentholum of 100 parts, the sorbitol of 100 parts, the sweeting agent of 100 parts, the distilled water of the edible essence of 100 parts and 9130 parts.
5. the radioprotective preventing decayed tooth antiinflammatory speed based on the mouth cavity medicine compositions of radioprotective preventing decayed tooth according to claim 1 antiinflammatory collapses gargle tablet, it is characterized in that, in mass fraction, comprise the Semen Lablab Album extract of 300 parts, the grape pip procyanidin extract of 500 parts, the tea polyphenols of 500 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 100 parts, the ammonium hexafluorosilicate of 2 parts, the soluble starch of 500 parts, the mannitol of 5750 parts, the PVP K30 of 900 parts, the controlled micro crystallization cellulose of 1500 parts, the polyvinylpolypyrrolidone XL-10 of 500 parts, the dipeptide sweetener of 50 parts, the Mentholum of 200 parts, the edible essence of 10 parts.
6. based on the radioprotective preventing decayed tooth antiinflammatory effervescent tablet of the mouth cavity medicine compositions of radioprotective preventing decayed tooth according to claim 1 antiinflammatory, it is characterized in that, in mass fraction, comprise the Semen Lablab Album extract of 300 parts, the grape pip procyanidin extract of 1000 parts, the tea polyphenols of 1000 parts, the epidermal growth factor EGF of 0.05 part, the DP300 of 100 parts, the ammonium hexafluorosilicate of 2 parts, the soluble starch of 500 parts, the sodium bicarbonate of 4200 parts, the citric acid of 2800 parts, the dipeptide sweetener of 10 parts, the hydroxypropyl cellulose of 14 parts, 10 parts of polyethylene glycol 6000s, the edible essence of the Mentholum of 100 parts and 10 parts.
7. based on the radioprotective preventing decayed tooth antiinflammatory concentrated spray agent of the mouth cavity medicine compositions of radioprotective preventing decayed tooth according to claim 1 antiinflammatory, it is characterized in that, in mass fraction, comprise the Semen Lablab Album extract of 500 parts, the grape pip procyanidin extract of 1000 parts, the tea polyphenols of 1000 parts, the epidermal growth factor of 0.1 part, the DP300 of 200 parts, the ammonium hexafluorosilicate of 2 parts, the sorbitol of 1000 parts, the potassium carbonate of 100 parts, the sodium chloride of 100 parts, the mass fraction of 100 parts is the pilocarpine of 0.2%, the lignocaine of 200 parts, the Mentholum of 200 parts, the sweeting agent of 10 parts, the distilled water of the edible essence of 10 parts and 5550 parts.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105327337A (en) * | 2015-10-30 | 2016-02-17 | 中国人民解放军96617部队 | Anti-radiation anti-caries inflammation-diminishing oral preparation |
| CN108685835A (en) * | 2018-08-01 | 2018-10-23 | 金心国际商贸（深圳）有限公司 | A kind of multifunctional gargle |
| CN113197227A (en) * | 2021-03-24 | 2021-08-03 | 上海耐定工贸有限公司 | Bactericide for toothbrush sterilizing box |
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| CN102784317A (en) * | 2012-07-26 | 2012-11-21 | 李厚建 | Traditional Chinese medicine composition for treating aphtha |
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| CN102784317A (en) * | 2012-07-26 | 2012-11-21 | 李厚建 | Traditional Chinese medicine composition for treating aphtha |
Non-Patent Citations (3)
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| VELLINGIRI MAHESHU: "Effects of processing conditions on the stability of polyphenolic contents and antioxidant capacity of Dolichos lablab L.", 《J FOOD SCI TECHNOL》 * |
| 卢金清等: "白扁豆的研究进展", 《湖北中医杂志》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327337A (en) * | 2015-10-30 | 2016-02-17 | 中国人民解放军96617部队 | Anti-radiation anti-caries inflammation-diminishing oral preparation |
| CN108685835A (en) * | 2018-08-01 | 2018-10-23 | 金心国际商贸（深圳）有限公司 | A kind of multifunctional gargle |
| CN113197227A (en) * | 2021-03-24 | 2021-08-03 | 上海耐定工贸有限公司 | Bactericide for toothbrush sterilizing box |
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