Technical field
The present invention relates to a kind of preparation method of toothpaste, particularly a kind of toothpaste preparation method that contains povidone iodine.
Background technology
Dental plaque is the major reason that causes human two big oral disease dental caries, periodontitis.It is difficult for being eliminated, because it is water insoluble, certain viscosity is arranged, and adhesive force is good, and the formation of bacterial plaque is relevant with bacterial infection.The method that is used to control bacterial plaque at present is a lot, as mechanical means and pharmaceutical methods etc.Add antibacterial or sterilization composition such as hibitane etc. in the toothpaste, the most popular in the world antibacterial is pure as jade pure, all flora is had certain inhibitory action.But hibitane has bitterness, and is invalid to acid-fast bacilli, fungus, virogenetic infection; Pure as jadely purely be used the enol base polymer and thereby herbal component makes toothpaste have the potent biocidal efficacies of wide spectrum.Povidone iodine is a kind of broad-spectrum high efficacy disinfection preservative, and antibacterial, fungus and virus are all had killing action.Gargle with 1% betagen solution, to suppressing the formation of dental plaque, oral cavity infections such as prevention of periodontal disease and dental caries have certain curative effect, but owing to the solution short effect that influences performance dead time in the oral cavity.
Summary of the invention
Purpose of the present invention just provides a kind of tooth that can suppress and produces povidone iodine toothpaste of bacterial plaque and preparation method thereof.
The present invention is grouped into by following one-tenth, and its percentage by weight is: povidone iodine 1%, potassium iodate 0.01～0.03%, sodium carboxymethyl cellulose 0.5～1.5%, sodium lauryl sulphate 2～3%, sodium alginate 0.5～1%, sorbitol 13～18%, glycerol 25～30%, silica 1 5～20%, saccharin sodium 0.05～0.15%, Oleum menthae 0.5～1%, purified water 29～34%.Its preparation method: (1) is got sodium carboxymethyl cellulose and is added glycerol; (2) get sodium alginate and add the purified water dissolving; (3) (1), (2) are mixed, add sorbitol, stir; (4) get sodium lauryl sulphate and potassium iodate adds purified water, after the heating, add povidone iodine and saccharin sodium again, stir; (5) (4) are added in (3), mixing adds silicon dioxide, mixes thoroughly; (6) get Oleum menthae and be dissolved in the ethanol, Oleum menthae and alcoholic acid weight ratio are 1: 0.9～1.6, add in (5), mix thoroughly, and regulating pH with sodium dihydrogen phosphate or sodium hydrogen phosphate buffer is 5.5～6.5.
When povidone iodine toothpaste uses, can produce a large amount of foams, fully contact, increase the holdup time, be formed with effect preferably suppressing dental plaque with the tooth position; Simultaneously, adopt povidone iodine toothpaste to brush teeth, have mechanicalness to remove the effect of dental plaque, both combine can suppress tooth generation bacterial plaque effectively.
The applicant suppresses dental plaque to povidone iodine toothpaste and has been used as test.Select 18 experimenters to carry out successively that povidone iodine toothpaste is brushed teeth and 1% betagen solution is gargled to suppress the test of dental plaque, result such as following table:
Povidone iodine toothpaste suppresses the result of the test of bacterial plaque
Group experimenter's dental plaque index (x ± s)
Povidone iodine toothpaste group 18 0.21 ± 0.15
Betagen solution group 18 0.76 ± 0.48
There were significant differences between test group and matched group P＜0.01
Povidone iodine is a kind of strong oxidizer.Fade gradually under alkali condition, available iodine content reduces and loses activity.The abrasivus of povidone iodine toothpaste can not adopt conventional used precipitated calcium carbonate, because precipitated calcium carbonate is alkalescence, can reacts with povidone iodine and its available iodine content is descended.Povidone iodine toothpaste of the present invention adopts silicon dioxide to do abrasivus, regulates pH in the scope that povidone iodine is fit to sodium dihydrogen phosphate or sodium hydrogen phosphate buffer simultaneously, can guarantee the stable of povidone iodine quality.The povidone iodine toothpaste of the present invention's preparation is made stable accelerated test, and it is stable that quality keeps.The results are shown in following table:
Povidone iodine toothpaste stability test result
Experimental condition: 30 ℃ ± 2 ℃ of temperature, relative humidity 60% ± 5%
Time outward appearance available iodine content (%)
January reddish brown color 0.096
February reddish brown color 0.096
March reddish brown color 0.096
June reddish brown color 0.095
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment one
Preparation method of the present invention: (1) is got 1 kilogram of sodium carboxymethyl cellulose and is added 28 kilograms of glycerol, and swelling is disperseed, and places 12 hours; (2) get 0.8 kilogram of sodium alginate and add 5 kilograms of purification water dissolutioies; (3) with after (1), (2) liquid mixing, add 15 kilograms of sorbitol, be stirred to agranular transparent adhesive tape; (4) get 2.5 kilograms of sodium lauryl sulphates and 0.02 kilogram of potassium iodate adds 28.08 kilograms of purified water, place the heating in water bath dissolving, put cold after, adds 1 kilogram of povidone iodine and 0.1 kilogram of saccharin sodium and stirs and make it to dissolve; (5) (4) liquid is added in (3), stir, add 18 kilograms of silicon dioxide, stir; (6) get 0.5 kilogram of Oleum menthae and be dissolved in the ethanol of 1000 ml concns 95%, add in (5), stir, regulating pH with phosphate sodium dihydrogen buffer solution is 5.0, gets povidone iodine toothpaste double centner.
Embodiment two
Preparation method of the present invention: (1) is got 1.5 kilograms of sodium carboxymethyl cellulose and is added 30 kilograms of glycerol, and swelling is disperseed, and places 16 hours; (2) get 1 kilogram of sodium alginate and add 5.32 kilograms of purification water dissolutioies; (3) with after (1), (2) liquid mixing, add 13 kilograms of sorbitol, be stirred to into agranular transparent adhesive tape; (4) get 3 kilograms of sodium lauryl sulphates and 0.03 kilogram of potassium iodate adds 24 kilograms of purified water, place the heating in water bath dissolving, put cold after, adds 1 kilogram of povidone iodine and 0.15 kilogram of saccharin sodium and stirs and make it to dissolve; (5) (4) liquid is added in (3), stir, add 20 kilograms of silicon dioxide, stir; (6) get 1 kilogram of Oleum menthae and be dissolved in the ethanol of 1200 ml concns 95%, add in (5), stir, regulating pH with the sodium hydrogen phosphate buffer is 6.5, gets povidone iodine toothpaste double centner.