CN113398185B - Moistureproof five-flavor disinfection beverage granules and preparation method thereof - Google Patents
Moistureproof five-flavor disinfection beverage granules and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a damp-proof five-flavor disinfection beverage granule and a preparation method thereof, wherein the damp-proof five-flavor disinfection beverage granule is prepared by decocting honeysuckle, wild chrysanthemum, dandelion, herba violae and muskroot-like semiaquilegia root to obtain a decoction concentrated solution A, then adding a first auxiliary material into the decoction concentrated solution A, uniformly mixing the mixture by a colloid mill, performing spray drying to obtain a spray-dried material B, finally adding a second auxiliary material into the spray-dried material B, stirring and mixing the mixture, and performing dry granulation to obtain the damp-proof five-flavor disinfection beverage granule, wherein the first auxiliary material comprises polyvidone S630, beta-cyclodextrin and maltodextrin, and the second auxiliary material comprises dextrin, lactose and soluble starch. The five-flavor disinfection beverage granules provided by the invention have good moisture resistance and good stability.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine granule preparation, in particular to moistureproof five-flavor disinfection beverage granules and a preparation method thereof.
Background
The five-ingredient disinfection beverage granules are derived from Ju Qi twelve from Yi Zong jin Jian and Ke Xin Fa Jue, are the Qing Dynasty classic prescriptions and consist of honeysuckle, dandelion, wild chrysanthemum, herba violae and radix semiaquilegiae. Specifically, the five-flavor disinfection beverage granules have the effects of clearing away heat and toxic materials, dissipating stasis and treating sores. In modern clinic, it is mainly used for skin suppurative infection, pruritus, furuncle and antivirus.
The five-flavor disinfectant drink is a classic famous prescription preparation, is a prescription which is drawn by the national administration of traditional Chinese medicine and drug administration according to the Chinese medical law of the people's republic of China, and is recorded in the ancient classic famous prescription catalogue, wherein the prescription is preliminarily determined to be a granule. In recent years, pharmacological experiments show that: the five-flavor disinfectant beverage has strong bacteriostatic and bactericidal effects. Wherein, a plurality of medicinal materials such as honeysuckle, wild chrysanthemum flower and the like are widely used in the industries of cosmetics, medicines and the like and are well praised by the majority of doctors. Currently, antibiotics are generally used for clinically treating diseases such as antibiosis, antiphlogosis and antivirus, which leads to the consequences of overuse of antibiotics, increase of drug-resistant patients, large side effect and the like.
At present, the traditional Chinese medicine compound preparations with better antibacterial effect, strong anti-inflammatory action and small side effect exist in the market. With the continuous research and exploration of ancient menstruum in modern clinic, the five-flavor disinfectant has better antibacterial and antiviral effects and better development prospect. In the prior art, part of patents disclose the preparation method of five-flavor disinfection beverage granules.
For example, patent 1 discloses a novel five-flavor disinfectant drink, a preparation method and application (publication number: CN 110721247A): the novel five-flavor disinfection beverage comprises the following raw material medicines in parts by weight: 5-10 parts of gynura bicolor seeds, 5-9 parts of stiff silkworm, 6-12 parts of white mulberry root-bark, 10-20 parts of honeysuckle, 10-12 parts of wild chrysanthemum flowers, 10-12 parts of dandelion, 5-10 parts of Chinese violet and 3-10 parts of liquorice. The corresponding preparation method comprises the following steps: weighing the raw materials according to the selected weight parts, adding 4-20 times of water, decocting twice for 2 hours each time, filtering, and combining the filtrates; concentrating the filtrate to obtain a thick paste with the relative density of 1.18-1.19 (25 ℃), adding ethanol with the volume equivalent to 1 time of the thick paste, shaking up, standing for 2-3 h for precipitation, filtering, recovering ethanol from the filtrate, concentrating to obtain the thick paste with the relative density of 1.18-1.19 (25 ℃), and drying. Grinding the dried thick paste into fine powder of 60 meshes, adding conventional adjuvants into the obtained fine powder, and preparing into oral preparation by conventional process. The medicine combination enables the efficacies of all the medicines to generate synergistic effect, thereby being capable of effectively treating wind-heat evil toxin, lung heat cough, dry stool, red tongue, yellow or greasy tongue coating and other symptoms caused by the acute bronchitis of children.
The prior patent 2 discloses a preparation method of a five-flavor disinfection beverage (publication number: CN 108714177A), which comprises the following steps: weighing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of gynura bicolor seed by weight to obtain the medicinal material of the prescription. Then, putting the prescription medicinal materials into an extraction tank, adding water in an amount which is 12 times the weight of the prescription medicinal materials, adding cellulose powder in an amount which is 1/10 times the weight of the prescription medicinal materials, soaking for 1 hour, extracting for 1 hour in a vacuum manner, and filtering to obtain filtrate I and dregs I; putting the residue I into an extraction tank, adding 10 times of water, vacuum-extracting for 30min, and filtering to obtain filtrate II; mixing the filtrate I and the filtrate II, and filtering and concentrating to obtain a concentrated solution 2 times of the weight of the medicinal materials in the prescription; centrifuging the concentrated solution to obtain centrifugate, and freeze drying the centrifugate for 36-48h to obtain dry extract of the five-flavor disinfectant beverage.
The prior patent 3 discloses a preparation technology and a production method of an integrated new formulation of a five-flavor disinfection beverage (with the publication number being CN 102283948A), wherein the raw materials of active ingredients comprise the following components in parts by weight: 15 parts of honeysuckle, 12 parts of wild chrysanthemum, 12 parts of dandelion, 15 parts of Chinese violet and 6 parts of Chinese violet. The production process comprises the following steps: supersonic airflow pulverizing, alcohol-water extraction, ultrasonic pulverizing extraction, water decoction concentration, supersonic spray drying, nanometer grinding, high pressure homogenizing, and nanoparticle preparation.
The prior patent 4 discloses a modern Chinese medicinal oral preparation of five-ingredient disinfectant drink and a production method thereof (the publication number is CN 1814058A), and the oral preparation product is composed of extracts of five Chinese medicinal materials such as honeysuckle, wild chrysanthemum flower, dandelion, Chinese violet, muskroot-like semiaquilegia root and the like, a sweetening agent, a preservative, auxiliary materials, water and the like. The specific preparation process comprises the following steps: (1) firstly, soaking honeysuckle, wild chrysanthemum, dandelion, herba violae and muskroot-like semiaquilegia root medicinal materials for 10-60 min, then boiling the medicinal materials by 5-25 times of water, and decocting the medicinal materials for 1-3 h; decocting for 2-3 times; (2) the water adding amount of the second decoction and the third decoction is 2/3 of the first decoction, and the decoction is carried out for 0.5 to 3 hours. Or, using water with the pH value of 1-2 as a first decoction, using water with the pH value of 9-10 as a second decoction and a third decoction, and decocting for 0.5-3 h; (3) mixing decoctions, filtering, removing residues, and concentrating the filtrate under reduced pressure until each ml of concentrated solution is equivalent to the amount of the crude drugs of 0.5-4 g; (4) adding 60% -95% ethanol until the ethanol content reaches 55% -85%, standing for 12-48 h, filtering out impurities, and recovering ethanol for later use. Or centrifuging the extraction filtrate by using a separator, taking supernatant, adding water for blending, and performing ultrafiltration by using an ultrafilter under the ultrafiltration pressure of 0.1-0.25 MPa, wherein the ultrafiltrate is reserved; (5) adding sweetening agent, etc., stirring, and mixing; adding water to adjust the mixture to the preparation amount. Sterilizing, filling or making into pill, inspecting, and packaging to obtain five-ingredient oral liquid or dripping pill preparation; (6) or further concentrating the concentrated solution to obtain extract, adding adjuvants such as sucrose and dextrin, granulating, drying, and packaging to obtain WUWEIDISHIYIN granule; or tabletting to obtain five-flavor disinfectant beverage tablet; or the five-flavor disinfection drink capsule is obtained by a capsule filling process.
For traditional Chinese medicine, the chemical components contained in the traditional Chinese medicine are complex, and the traditional Chinese medicine has strong hygroscopicity no matter whether the traditional Chinese medicine is biological active components such as alkaloids, glycosides, volatile oil, amino acids and the like or non-biological active components such as saccharides, proteins, pigments, resins and inorganic salts. It is understood that after the drug absorbs moisture, the physical changes of the preparation are caused: such as deepening, softening and caking, which directly affect the particle size, fluidity, compressibility and viscosity of the Chinese medicinal extract. At the same time, chemical changes are often also induced: for example, hydrolysis and oxidation of the drug ingredients are accelerated, which leads to changes in the ingredients, and stability, safety and efficacy are affected to some extent. Therefore, the problem of moisture absorption of the traditional Chinese medicine preparation is always a common problem in the pharmaceutical industry.
Disclosure of Invention
Based on the above, the invention aims to solve the problem that the existing traditional Chinese medicine preparation generally has moisture absorption to cause physical change and chemical change of the medicine, so that the curative effect is influenced.
The invention provides a moisture-proof five-flavor disinfection beverage granule, which is prepared by decocting honeysuckle, wild chrysanthemum, dandelion, herba violae and muskroot-like semiaquilegia root to obtain a decoction concentrated solution A, adding a first auxiliary material into the decoction concentrated solution A, uniformly mixing the mixture by a colloid mill, spray-drying the mixture to obtain a spray-dried material B, adding a second auxiliary material into the spray-dried material B, stirring and mixing the mixture, and performing dry granulation.
The moisture-proof five-flavor disinfection beverage granules are prepared from the following components in parts by weight: 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root;
the density of the concentrated solution A obtained after decoction is 1.05-1.15, and the solid content in the concentrated solution A is 15% -30%;
wherein the first auxiliary material and the decoction concentrated solution A are added in the following weight portions: 70-90 parts of a decoction concentrated solution A and 10-30 parts of a first auxiliary material;
the second auxiliary material and the spray-dried material B are added in the following weight parts: 70-90 parts of spray-dried material B and 10-30 parts of second auxiliary material.
The moisture-proof five-flavor disinfection beverage granules are characterized in that in the step of spray drying, the air inlet temperature is as follows: 120-140 ℃, air outlet temperature: 80-90 ℃, atomization pressure: 0.4Mpa, liquid supply rate: 10 ml/min;
in the stirring and mixing step, the stirring speed: 250r/min, shear rate: the speed of the air is 2000r/min,
stirring and shearing time: 3 min;
in the dry granulation step, roller pressure: 45-75 bar, feeding speed of 30-50 r/min: roller clearance 1.0 ~ 3.0mm, roller speed: 3.0 to 5.0 r/min.
The invention also provides a preparation method of the moisture-proof five-flavor disinfection beverage granules, which is used for preparing the moisture-proof five-flavor disinfection beverage granules, wherein the method comprises the following steps:
mixing flos Lonicerae, flos Chrysanthemi Indici, herba Taraxaci, herba Violae and radix Semiaquilegiae, decocting with water, adding yellow wine, decocting, repeating twice, sieving the combined medicinal liquids, and concentrating to obtain concentrated solution A;
adding a first auxiliary material into the concentrated solution A, uniformly mixing the mixture through a colloid mill, sieving the mixture, and then performing spray drying to obtain a spray-dried material B, wherein the first auxiliary material comprises copovidone S630, beta-cyclodextrin and maltodextrin;
and adding a second auxiliary material into the spray-dried material B, stirring and mixing, then placing the mixed material into a dry granulating machine for granulating, sieving and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises dextrin, lactose and soluble starch.
The preparation method of the moisture-proof five-flavor disinfection beverage granules provided by the invention comprises the steps of carrying out compounding and screening on different auxiliary materials with strong moisture absorption resisting capacity, mixing the concentrated solution and the auxiliary materials by a colloid mill, and then carrying out spray drying to obtain a spray-dried material B. The spray drying method is adopted, and the ordered particle surface coating can be carried out on the surface of the medicine, so that a core-shell design is formed, and the powder properties of the granules are improved. At the same time, the final dry granulation enhances the moldability of the granules, ensuring that the granules do not undergo changes in physical and chemical properties due to moisture absorption.
The preparation method of the moistureproof five-flavor disinfection beverage granules comprises the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5-20 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05-1.15 and the solid content is 15-30% to obtain a concentrated solution A;
taking 70-90 parts of the concentrated solution A, adding 10-30 parts of a first auxiliary material, sieving with a 100-mesh sieve after uniformly mixing through a colloid mill, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary material comprises copovidone S630, betacyclodextrin and maltodextrin;
and taking 70-90 parts of the spray-dried material B, adding 10-30 parts of a second auxiliary material, stirring and mixing the obtained mixed material, placing the mixed material in a dry-method granulator, granulating, sieving by a 20-mesh sieve, granulating, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises dextrin, maltodextrin, lactose and soluble starch.
The preparation method of the moisture-proof five-flavor disinfection beverage granules comprises the following steps of: 120-140 ℃, air outlet temperature: 80-90 ℃, atomization pressure: 0.4Mpa, liquid supply rate: 10 ml/min;
in the stirring and mixing step, the stirring speed: 250r/min, shear rate: the speed of the water is 2000r/min,
stirring and shearing time: 3 min;
in the dry granulation step, roller pressure: 45-75 bar, feeding speed of 30-50 r/min: roller clearance 1.0 ~ 3.0mm, roller speed: 3.0 to 5.0 r/min.
The preparation method of the moisture-proof five-flavor disinfection beverage granules comprises the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating until the density is 1.05 and the solid content is 15% to obtain concentrated solution A;
taking 90 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving with a 100-mesh sieve after uniformly mixing through a colloid mill, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary materials comprise copovidone S630, betacyclodextrin and maltodextrin, and the weight part ratio of the copovidone S630 to the betacyclodextrin to the maltodextrin is 1:1: 8;
and taking 70 parts of the spray-dried material B, adding 30 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, placing the mixed material in a dry granulator, granulating, sieving by a 20-mesh sieve, granulating, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises lactose and soluble starch, and the corresponding weight part ratio of the lactose to the soluble starch is 1: 1.
The preparation method of the moistureproof five-flavor disinfection beverage granules comprises the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 10 times that of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.10 and the solid content is 20% to obtain concentrated solution A;
taking 90 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving with a 100-mesh sieve after uniformly mixing through a colloid mill, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary materials comprise copovidone S630, betacyclodextrin and maltodextrin, and the weight part ratio of the copovidone S630 to the betacyclodextrin to the maltodextrin is 2.5:2.5: 5;
taking 80 parts of the spray-dried material B, adding 20 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, placing the mixed material in a dry-method granulator, granulating, sieving by a 20-mesh sieve, grading, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises dextrin and lactose, and the weight ratio of the lactose to the dextrin is 1: 1.
the preparation method of the moistureproof five-flavor disinfection beverage granules comprises the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water 15 times the volume of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.15 and the solid content is 25% to obtain concentrated solution A;
taking 90 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving with a 100-mesh sieve after uniformly mixing through a colloid mill, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary materials comprise copovidone S630, betacyclodextrin and maltodextrin, and the weight part ratio of the copovidone S630 to the betacyclodextrin to the maltodextrin is 5:2: 3;
and (2) taking 95 parts of the spray-dried material B, adding 10 parts of a second auxiliary material, stirring and mixing the obtained mixed material, placing the mixed material in a dry-method granulator, granulating, sieving by a 20-mesh sieve, grading, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises lactose and maltodextrin, and the weight part ratio of the lactose to the maltodextrin is 1: 1.
The preparation method of the moistureproof five-flavor disinfection beverage granules comprises the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 20 times that of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating until the density is 1.15 and the solid content is 30% to obtain concentrated solution A;
taking 80 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, uniformly mixing by using a colloid mill, sieving by using a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary materials comprise copovidone S630, betacyclodextrin and maltodextrin, and the weight part ratio of the copovidone S630 to the betacyclodextrin to the maltodextrin is 3:2: 5;
and taking 70 parts of the spray-dried material B, adding 10 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, placing the mixed material in a dry-method granulator, granulating, sieving by a 20-mesh sieve, granulating, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises soluble starch and dextrin, and the weight part ratio of the soluble starch to the dextrin is 1: 2.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a flow chart of a preparation method of the moisture-proof five-flavor disinfection beverage granules provided by the invention.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
It is well known that moisture absorption of a drug causes not only physical changes in the formulation: such as deepening, softening and caking, which directly affect the particle size, fluidity, compressibility and viscosity of the Chinese medicinal extract. At the same time, chemical changes are often also induced: for example, hydrolysis and oxidation of the drug ingredients are accelerated, which leads to changes in the ingredients, and stability, safety and efficacy are affected to some extent.
The existing damp-proof method for traditional Chinese medicines generally comprises the following steps: the preparation method comprises the steps of extraction, separation and purification of the traditional Chinese medicine, a proper drying mode, use of moisture-proof auxiliary materials, optimization of a granulation method, coating, moisture-proof packaging, storage in an environment with lower relative humidity and the like. In actual production, the moisture absorption of the preparation is usually reduced by screening the types and the amounts of auxiliary materials because the extraction and refining processes of the preparation are inconvenient to change.
Long-term experiments prove that: if the index components of the product are not changed, the hygroscopicity of the product is reduced. The dosage of the auxiliary materials is increased (generally, the dosage of the extract and the auxiliary materials is 1:1 or 1: 2). The aim of reducing the dosage of the auxiliary materials and the dosage and the production cost of the patients cannot be realized.
Based on the problem, the invention provides the moisture-proof five-flavor disinfection beverage granules and the preparation method thereof according to the series combination of physical characteristics among auxiliary materials and the modern formation preparation process means, thereby providing safe, effective and convenient-to-carry favorable medicines for patients.
The invention provides a moisture-proof five-flavor disinfection beverage granule which is prepared by decocting 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a decoction concentrated solution A; then adding a first auxiliary material into the decoction concentrated solution A, uniformly mixing the mixture through a colloid mill, and performing spray drying to obtain a spray-dried material B; and finally, adding a second auxiliary material into the spray-dried material B, stirring and mixing, and performing dry granulation to obtain the moisture-proof five-flavor disinfection beverage granules.
It should be noted that the first auxiliary materials include copovidone S630, betacyclodextrin and maltodextrin, and the second auxiliary materials include dextrin, lactose and soluble starch.
In addition, the density of the concentrated solution A obtained after decoction is 1.05-1.15, and the solid content in the concentrated solution A is 15-30%. Wherein the first auxiliary materials and the decoction concentrated solution A are respectively added in the following weight portions: 70-90 parts of a decoction concentrated solution A and 10-30 parts of a first auxiliary material. The second auxiliary material and the spray-dried material B are added in the following weight portions: 70-90 parts of spray-dried material B and 10-30 parts of second auxiliary material.
Meanwhile, in the above-mentioned spray drying step, the inlet air temperature: 120-140 ℃, air outlet temperature: 80-90 ℃, atomization pressure: 0.4Mpa, liquid supply rate: 10 ml/min. In the above stirring and mixing step, the stirring speed: 250r/min, shear rate: 2000r/min, stirring and shearing time: 3 min.
In the above dry granulation step, roller pressure: 45-75 bar, feeding speed of 30-50 r/min: roller clearance 1.0 ~ 3.0mm, roller speed: 3.0 to 5.0 r/min.
Referring to fig. 1, the present invention provides a method for preparing moisture-proof five-flavor disinfection beverage granules, which is used for preparing the moisture-proof five-flavor disinfection beverage granules, wherein the method comprises the following steps:
the method comprises the following steps: mixing flos Lonicerae, flos Chrysanthemi Indici, herba Taraxaci, herba Violae and radix Semiaquilegiae, decocting with water, adding yellow wine, decocting, repeating twice, sieving the combined medicinal liquids, and concentrating to obtain concentrated solution A.
Specifically, in the step, 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root are mixed to obtain a mixed medicinal material, water with the volume 5-20 times that of the mixed medicinal material is added, and the mixture is decocted for 50 min. Adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 hr. Repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating until the density is 1.05-1.15 and the solid content is 15-30% to obtain a concentrated solution A.
It should be noted that, yellow wine is added during decoction, and the medicinal ingredients in the medicinal materials can be removed more thoroughly in the decoction process due to the ester-soluble ingredients in the yellow wine. Meanwhile, because the yellow wine is rich in amino acid, polysaccharide and other components, the curative effect of the finally prepared five-flavor disinfection beverage granules can be improved, and the effects of promoting qi and activating blood circulation are improved.
Step two: and adding a first auxiliary material into the concentrated solution A, uniformly mixing the mixture through a colloid mill, sieving the mixture, and then performing spray drying to obtain a spray-dried material B, wherein the first auxiliary material comprises copovidone S630, beta-cyclodextrin and maltodextrin.
In the step, 70-90 parts of concentrated solution A are taken, 10-30 parts of first auxiliary materials are added, the concentrated solution A is uniformly mixed by a colloid mill, and then is sieved by a 100-mesh sieve, and spray drying is carried out, so that spray-dried material B is obtained. Wherein the first adjuvant comprises copovidone S630, betacyclodextrin and maltodextrin.
It should also be noted that, in the step of spray drying, the inlet air temperature: 120-140 ℃, air outlet temperature: 80-90 ℃, atomization pressure: 0.4Mpa, liquid supply rate: 10 ml/min.
Step three: and (3) adding a second auxiliary material into the spray-dried material B, stirring and mixing, then placing the mixed material into a dry granulating machine for granulating, sieving and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises dextrin, lactose and soluble starch.
In the step, 70-90 parts of spray-dried material B is taken, 10-30 parts of second auxiliary material is added to be stirred and mixed, then the obtained mixed material is stirred and mixed, and the mixed material is placed in a dry-method granulator to be granulated. And then sieving with a 20-mesh sieve, granulating, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules. Wherein the second auxiliary materials comprise dextrin, maltodextrin, lactose and soluble starch.
In the step of adding the second auxiliary material for stirring and mixing, the stirring speed is as follows: 250r/min, shear rate: 2000r/min, stirring and shearing time: 3 min. Furthermore, in the dry granulation step, the roller pressure: 45-75 bar, feeding speed of 30-50 r/min: roller clearance 1.0 ~ 3.0mm, roller speed: 3.0 to 5.0 r/min.
The preparation method of the moisture-proof five-flavor disinfection beverage granules provided by the invention comprises the steps of carrying out compounding and screening on different auxiliary materials with strong moisture absorption resisting capacity, mixing the concentrated solution and the auxiliary materials by a colloid mill, and then carrying out spray drying to obtain a spray-dried material B. The spray drying method is adopted, and the ordered particle surface coating can be carried out on the surface of the medicine, so that a core-shell design is formed, and the powder properties of the granules are improved. At the same time, the final dry granulation enhances the moldability of the granules, ensuring that the granules do not undergo changes in physical and chemical properties due to moisture absorption.
The technical solution proposed by the present invention will be described in more detail with reference to several specific examples.
The first embodiment is as follows:
the invention provides a preparation method of a moistureproof five-flavor disinfection beverage granule, which comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 5 times that of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 hr. And then repeating the steps twice, merging the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 15% to obtain concentrated solution A.
Step two: and (3) taking 90 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are respectively as follows:
copovidone S6301 parts
Beta-cyclodextrin 1 part
8 portions of maltodextrin
Step three: and taking 70 parts of the spray-dried material B, adding 30 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
In this step, the second excipients added include lactose and soluble starch. Wherein the weight portions of the components are respectively as follows:
lactose 15 parts
15 portions of soluble starch
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
The second embodiment:
the invention provides a preparation method of moisture-proof five-flavor disinfection beverage granules, which comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 10 times that of the mixed medicinal material, and decocting for 50 min. Adding yellow wine 5 times the volume of the mixed materials, and decocting for 10min for 1 hr. Repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.10 and the solid content is 20% to obtain concentrated solution A.
Step two: and (3) taking 90 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin.
Wherein the weight portions of the components are respectively as follows:
copovidone S6302.5 parts
Beta-cyclodextrin 2.5 parts
5 parts of maltodextrin
Step three: and (3) taking 80 parts of spray-dried material B, adding 20 parts of second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
Wherein the second auxiliary material comprises dextrin and lactose.
Wherein the weight portions of the components are respectively as follows:
lactose 10 parts
Dextrin 10 parts
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
Example three:
the invention provides a preparation method of moisture-proof five-flavor disinfection beverage granules, which comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 15 times that of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed materials, and decocting for 10min for 1 hr. Repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating until the density is 1.15 and the solid content is 25% to obtain concentrated solution A.
Step two: and (3) taking 90 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
Wherein the first adjuvant comprises copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are respectively as follows:
copovidone S6305 parts
Beta-cyclodextrin 2 parts
Maltodextrin 3 parts
Step three: and taking 95 parts of spray-dried material B, adding 10 parts of second auxiliary materials, stirring and mixing, then stirring and mixing the obtained mixed material, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
Wherein the second auxiliary material comprises lactose and maltodextrin. Wherein the weight portions of the components are respectively as follows:
lactose 5 parts
5 portions of maltodextrin
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
Example four:
the preparation method of the moistureproof five-flavor disinfection beverage granules provided by the fourth embodiment of the invention comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 20 times that of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating until the density is 1.15 and the solid content is 30% to obtain concentrated solution A.
Step two: and (3) taking 80 parts of the concentrated solution A, adding 10 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
Wherein the first adjuvant comprises copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are respectively as follows:
copovidone S6306 parts
Beta-cyclodextrin 4 parts
10 portions of bud dextrin
Step three: and taking 70 parts of the spray-dried material B, adding 10 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
Wherein, the second auxiliary material comprises soluble starch and dextrin. Wherein the weight portions of the components are respectively as follows:
10 portions of soluble starch
Dextrin 20 parts
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
Example five:
the invention provides a preparation method of moisture-proof five-flavor disinfection beverage granules, which comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed materials, and decocting for 10min for 1 hr. And then repeating the steps twice, merging the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 5% to obtain concentrated solution A.
Step two: and (3) taking 80 parts of the concentrated solution A, adding 20 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are respectively as follows:
copovidone S63010 parts
Beta-cyclodextrin 5 parts
5 portions of maltodextrin
Step three: and (3) taking 80 parts of spray-dried material B, adding 20 parts of second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
In this step, the second excipients added include lactose and soluble starch. Wherein the weight portions of the components are respectively as follows:
lactose 15 parts
Soluble starch 5 parts
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, stirring and mixing, and dry granulation.
Example six:
the invention provides a preparation method of moisture-proof five-flavor disinfection beverage granules, which comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed materials, and decocting for 10min for 1 hr. And then repeating the steps twice, merging the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 10% to obtain concentrated solution A.
Step two: and (3) taking 80 parts of the concentrated solution A, adding 20 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are as follows:
copovidone S6306 parts
Beta-cyclodextrin 8 parts
6 portions of maltodextrin
Step three: and (3) taking 80 parts of spray-dried material B, adding 20 parts of second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Then sieving with 100 mesh sieve, granulating, and packaging to obtain the final product.
In this step, the second excipients added include lactose and maltodextrin. Wherein the weight portions of the components are respectively as follows:
lactose 4 parts
6 portions of maltodextrin
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
Example seven:
the preparation method of the moisture-proof five-flavor disinfection beverage granules provided by the seventh embodiment of the invention comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 hr. And then repeating the steps twice, merging the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 15% to obtain concentrated solution A.
Step two: and taking 70 parts of the concentrated solution A, adding 30 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are respectively as follows:
copovidone S6301 parts
Betacyclodextrin 1 part
Maltodextrin 28 parts
Step three: and taking 70 parts of the spray-dried material B, adding 30 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
In this step, the second excipients added include dextrin and soluble starch. Wherein the weight portions of the components are respectively as follows:
dextrin 15 parts
15 portions of soluble starch
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
Example eight:
the invention provides a preparation method of moisture-proof five-flavor disinfection beverage granules, which comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 hr. And then repeating the steps twice, merging the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 20% to obtain concentrated solution A.
Step two: and taking 70 parts of the concentrated solution A, adding 30 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are respectively as follows:
copovidone S63010 part
10 portions of beta-cyclodextrin
10 portions of maltodextrin
Step three: and (3) taking 80 parts of spray-dried material B, adding 20 parts of second auxiliary materials, stirring and mixing, then stirring and mixing the obtained mixed material for 3min, and placing the mixed material in a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
In this step, the second excipients include dextrin and lactose. Wherein the weight portions of the components are respectively as follows:
dextrin 5 parts
Lactose 15 parts
It should be noted that in the actual processing, the processing parameters can be set by referring to the above parameter ranges in the steps of spray drying, stirring and mixing and dry granulation
Example nine:
the preparation method of the moistureproof five-flavor disinfection beverage granules provided by the ninth embodiment of the invention comprises the following steps:
the method comprises the following steps: mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 hr. And then repeating the steps twice, merging the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 20% to obtain concentrated solution A.
Step two: and taking 70 parts of the concentrated solution A, adding 30 parts of first auxiliary materials, sieving by a colloid mill, uniformly mixing, sieving by a 100-mesh sieve, and performing spray drying to obtain a spray-dried material B.
In this step, the first excipients added include copovidone S630, betacyclodextrin and maltodextrin. Wherein the weight portions of the components are as follows:
copovidone S6305 parts
Beta-cyclodextrin 5 parts
Maltodextrin 20 parts
Step three: and (3) taking 90 parts of spray-dried material B, adding 10 parts of second auxiliary material, stirring and mixing the obtained mixed material for 3min, and putting the mixed material into a dry-method granulator for granulation. Sieving with 20 mesh sieve, grading, and packaging to obtain the final product.
In this step, the second excipients added include lactose and soluble starch. Wherein the weight portions of the components are respectively as follows:
lactose 5 parts
Soluble starch 5 parts
It should be noted that, in the actual processing, the processing parameters may be set with reference to the above parameter ranges in the steps of spray drying, agitation mixing and dry granulation.
Calculating the powder rate of the spray-dried material, and performing moisture measurement according to the moisture measurement requirement of 2020 edition Chinese pharmacopoeia. In addition, the total mixed material is granulated by a dry method, the finishing is carried out, the granule yield is calculated, and the prepared granules are subjected to a moisture-wicking test according to the guiding principle of a medicament moisture-wicking test in 'Chinese pharmacopoeia' 2020 edition.
Test data table for detection items
And displaying through the data:
in the first to ninth embodiments of the present invention, the yield of the spray-dried material and the granule yield of the five-flavor disinfection beverage granule obtained after granulation are both above 85%, and the water content is below 6% (the lower the water content of the solid preparation is, the better the physical stability is), so that the yield and the stability of the prescription of the preparation process are ensured. Further, it was found by the hygroscopicity test that: the highest moisture absorption rate is within 10 percent, and the particles are in a dispersed state and are not agglomerated. The five-flavor disinfection beverage particles prepared by the invention are proved to have good moisture resistance.
The five-flavor disinfection beverage particles prepared by the invention have the following beneficial effects:
(1) high moisture resistance and stability
According to the invention, different auxiliary materials with strong moisture absorption resisting capacity are compounded and screened, the concentrated solution and the auxiliary materials are mixed by a colloid mill, and then spray drying is adopted to obtain a spray-dried material B. The spray drying method is adopted, and the ordered particle surface coating can be carried out on the surface of the medicine, so that a core-shell design is formed, and the powder properties of the granules are improved. Meanwhile, the dry granulation process enhances the moldability of the granules, and ensures that the granules do not undergo changes in physical and chemical properties due to moisture absorption.
(2) Low auxiliary material amount and production cost
The moisture-proof five-ingredient disinfection beverage traditional Chinese medicine granules prepared by the invention have the advantages that the dosage range of auxiliary materials is controlled to be 20-30%, the moisture resistance is ensured, and meanwhile, the production cost is reduced.
Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, which are used for illustrating the technical solutions of the present invention and not for limiting the same, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (4)
1. The moisture-proof five-flavor disinfection beverage granules are characterized in that the preparation method of the moisture-proof five-flavor disinfection beverage granules comprises the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain a mixed medicinal material, adding water with the volume 5 times that of the mixed medicinal material, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 20% to obtain concentrated solution A;
taking 70 parts of the concentrated solution A, adding 30 parts of a first auxiliary material, sieving with a 100-mesh sieve after uniformly mixing through a colloid mill, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary material comprises copovidone S630, betacyclodextrin and maltodextrin, and the corresponding parts by weight of the copovidone S630, the betacyclodextrin and the maltodextrin are respectively 10 parts, 10 parts and 10 parts;
and (2) taking 80 parts of the spray-dried material B, adding 20 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, placing the mixed material in a dry-method granulator, granulating, sieving by a 20-mesh sieve, grading, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises 5 parts of dextrin and 15 parts of lactose respectively in parts by weight corresponding to the dextrin and the lactose.
2. The moisture-proof five-flavor disinfectant beverage granule according to claim 1, wherein in the step of spray-drying, the inlet air temperature: 120-140 ℃, air outlet temperature: 80-90 ℃, atomization pressure: 0.4Mpa, liquid supply rate: 10 ml/min;
in the stirring and mixing step, the stirring speed: 250r/min, shear rate: 2000r/min, stirring and shearing time: 3 min;
in the dry granulation step, roller pressure: 45-75 bar, feeding speed of 30-50 r/min: roller clearance 1.0 ~ 3.0mm, roller speed: 3.0 to 5.0 r/min.
3. A preparation method of moisture-proof five-flavor disinfection beverage granules is characterized by comprising the following steps:
mixing 2.5 parts of honeysuckle, 1 part of wild chrysanthemum flower, 1 part of dandelion, 1 part of Chinese violet and 1 part of muskroot-like semiaquilegia root to obtain mixed medicinal materials, adding water with the volume 5 times that of the mixed medicinal materials, and decocting for 50 min; adding yellow wine 5 times the volume of the mixed medicinal materials, and decocting for 10min for 1 h; repeating the steps twice, mixing the liquid medicines obtained in the two steps, sieving the liquid medicines with a 200-mesh sieve, and concentrating the liquid medicines until the density is 1.05 and the solid content is 20% to obtain concentrated solution A;
taking 70 parts of the concentrated solution A, adding 30 parts of a first auxiliary material, sieving with a 100-mesh sieve after uniformly mixing through a colloid mill, and performing spray drying to obtain a spray-dried material B, wherein the first auxiliary material comprises copovidone S630, betacyclodextrin and maltodextrin, and the corresponding parts by weight of the copovidone S630, the betacyclodextrin and the maltodextrin are respectively 10 parts, 10 parts and 10 parts;
and taking 70 parts of the spray-dried material B, adding 30 parts of a second auxiliary material, stirring and mixing the obtained mixed material for 3min, placing the mixed material in a dry granulating machine for granulation, sieving with a 20-mesh sieve for granulation, and packaging to obtain the moisture-proof five-flavor disinfection beverage granules, wherein the second auxiliary material comprises 5 parts of dextrin and 15 parts of lactose respectively in parts by weight corresponding to the dextrin and the lactose.
4. The method for preparing moisture-proof five-flavor disinfection beverage granules according to claim 3, wherein in the step of spray drying, the air inlet temperature is: 120-140 ℃, air outlet temperature: 80-90 ℃, atomization pressure: 0.4Mpa, liquid supply rate: 10 ml/min;
in the stirring and mixing step, the stirring speed: 250r/min, shear rate: 2000r/min, stirring and shearing time: 3 min;
in the dry granulation step, roller pressure: 45-75 bar, feeding speed of 30-50 r/min: roller clearance 1.0 ~ 3.0mm, roller speed: 3.0 to 5.0 r/min.
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| CN101862458A (en) * | 2010-06-21 | 2010-10-20 | 谭登平 | Auxiliary material combination for improving atomizing and drying process of traditional Chinese medicine granules and application thereof |
| CN111494458A (en) * | 2020-05-18 | 2020-08-07 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
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| CN101862458A (en) * | 2010-06-21 | 2010-10-20 | 谭登平 | Auxiliary material combination for improving atomizing and drying process of traditional Chinese medicine granules and application thereof |
| CN111494458A (en) * | 2020-05-18 | 2020-08-07 | 广州市香雪制药股份有限公司 | Preparation method of patchouli formula granules |
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