CN1030038C - Method for preparation of medicament by using carrot as auxiliary material - Google Patents
Method for preparation of medicament by using carrot as auxiliary material Download PDFInfo
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- CN1030038C CN1030038C CN 91101137 CN91101137A CN1030038C CN 1030038 C CN1030038 C CN 1030038C CN 91101137 CN91101137 CN 91101137 CN 91101137 A CN91101137 A CN 91101137A CN 1030038 C CN1030038 C CN 1030038C
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- dauci sativae
- radix dauci
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Abstract
The present invention relates to a medicament preparation method using carrots as adjuvant materials of medicaments, which belongs to the applications of new adjuvant materials of Chinese medicaments in preparations. In the medicament preparation method of the present invention, the cheap carrots rich in nutrition are used as the adjuvant materials of the medicaments. The carrots are cured, are ground to be pulp and are mixed with Chinese medicine extract or other medicines in a form of excipient after pulverized in ultrafine particles and dried to prepare proper preparations such as suspensions, granules, etc. in different concentrations. On the premise of meeting the design functions and the main treatment diseases of original medicines, the consumption of cane sugar and starch in the original preparations is reduced, and the requirements of patients to the micro nutrients of vitamins, carotene, etc. are also met. Therefore, the integral therapeutic effects of the medicaments are improved.
Description
The present invention relates to a kind ofly, belong to dispersion, pulverizing and the mixed method of physics with the medicament preparation method of Radix Dauci Sativae as pharmaceutical necessities.
The basic task of pharmaceutics is: how medicine is made suitable dosage form, and the adjuvant of the development of dosage form and medicament has confidential relation, mainly contain starch, sugar and some coating materials etc. for oral pharmaceutic adjuvant at present, its adjuvant itself does not have the effect that improves curative effect of medication, and present some commercially available electuaries, sugar contents such as oral liquid are too high, and old man, patient are difficult for adhering to often taking.
The objective of the invention is to adopt Radix Dauci Sativae to make a series of preparations and replace starch and the sucrose of widely applying at present with part as medicinal excipient.Radix Dauci Sativae is a kind of high yield vegetable of cheapness, contain trace nutrients such as more rich carotene, simultaneously, Radix Dauci Sativae has processing characteristics preferably, and its goods have good organoleptic attribute, therefore with Radix Dauci Sativae through pulverize, after degassing taste removal and the homogenizing drying as medicinal excipient, not only uniform and stable, the economical rationality of medicament, and can utilize the biological activity of carotene in the adjuvant itself, give full play to trace nutrient in treatment with the effect in getting well, thereby improve the general curative effect of preparation.
The present invention realizes by following technical process:
The preparation of a, Radix Dauci Sativae excipient
Immerse immediately after the Radix Dauci Sativae fragmentation in 1% saline or 0.5% citric acid and prevent enzymatic browning, under 95-100 ℃ of condition, ripening 8-12 minute, finish grind 50-100 μ m, be the mud shape, at 85-90 ℃, taste removal outgases under the vacuum 0.08-0.09MPa condition, carry out high pressure homogenize at pressure 10-25MPa and handle, obtain the mashed carrot substrate of content 20-40%, standby according to all right spraying drying powder-forming of instructions for use.
B. the preparation of suspensoid, syrup, fluid extract: with drug extract/liquid in proportion with a in the degassing before mashed carrot mixes, the adding acidic flavoring agent, in a technology, outgas, obtain stable liquid or mastic preparation behind the high pressure homogenize.
C. electuary preparation: the dry extract or the medicated powder of drug extract are mixed with the mashed carrot that passes through a spray drying treatment, add an amount of flavoring agent, the binding agent mixing granulation gets final product.
D. the preparation of tablet: the dry extract or the medicine branch of drug extract are mixed an amount of disintegrating agent of adding, mixing granulation, tabletting etc. with the Radix Dauci Sativae powder of process a spray drying treatment.
The total amount that adds Radix Dauci Sativae in pharmaceutical preparation is 20-80%, and acidic flavoring agent can be rice vinegar or citric acid, sweeting agent can be selected sucrose or Folium Stevlae Rebaudianae etc. for use, and binding agent can be selected syrup, Mel, dextrin etc. for use.
Describe technology contents of the present invention in detail below in conjunction with embodiment.
Embodiment 1: the preparation of Radix Dauci Sativae excipient
The Radix Dauci Sativae raw material should be Fresh ﹠ Tender in Texture, meat and stem are orange red, the center does not have thick muscle, the no disease and pest and the phenomenon of going rotten, during washing, should brush silt particle in the wrinkle of most top layer, reuse rinsed with deionized water raw material, raw material can be cut into slices or silk, and cutting knife and charging basket are stainless steel material, for avoiding shredding rear oxidation, chipper casing and charging basket spray into steam, and the raw material of chopping carries out the heat kill enzyme immediately, in case oxidizing brown stain, burn water is the deionized water that contains 0.5% citric acid, processing time 8-12 ℃, treatment temperature 95-100 ℃, pull out and drain and cool off, make the mashed carrot that becomes 50-100 μ m with colloid mill correct grinding material, mashed carrot is arrived 85-90 ℃ with Steam Heating, and vacuum is following jar of interior degassing of 0.08-0.09MPa condition 8-10 minute, carries out homogenizing after the cooling, just homogenization pressure is 10-15MPa, second homogenate is carried out vacuum outgas processing after adopting high pressure 20-25MPa homogenizing again, obtains the mashed carrot of concentration 20-40%, and spray drying is standby.
In addition, the processing of the dry powder of mashed carrot can also be adopted Radix Dauci Sativae heat kill enzyme convection drying later on, and the method for Fen Suiing is manufactured Chinese medicine pill, tablet excipient then.
Embodiment 2: the medicament preparation
Embodiment 2-1 clearing away heat and promoting production of body fluid pulp.
Clearing away heat-fire, YIN nourishing and the production of body fluid promoting is used for oral ulcer
Prescription: Flos Lonicerae 90 grams, Folium Bambusae 60 grams, Rhizoma Phragmitis 60 grams,
Restrain Radix Ophiopogonis 60, Radix Adenophorae (Radix Glehniae) 45 grams, and mashed carrot 500 grams,
Mel 90 grams, sucrose 90 grams, rice vinegar 60 grams.
Method for making: with Flos Lonicerae, Folium Bambusae, Rhizoma Phragmitis, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae) are cleaned with deionized water, the deionized water that adds 10 times of amounts of medical material soaks to boil after 30 minutes carries 3 times, each 1 hour, merging decoction liquor filters, evaporation and concentration is to 360ml, add rice vinegar, Mel and sucrose boil after-filtration after mixing, the ground mashed carrot mix homogeneously of filtrate and colloidal quality, homogenization pressure is 15MPa, reuse high-pressure section homogenizing to use the homogenizer low-pressure section to carry out just, pressure is 25MPa, and the mixture slurry behind the homogenizing is heated to 85 ℃.When vacuum reaches 0.09MMPa, outgas sterilization encapsulation then.
Embodiment 2-2 sets upright pulp
Replenishing QI to invigorate the spleen, nourishing the liver and kidney improve immunologic function, cooperate " chemotherapy " " radiotherapy " to use to controlling the cancer adjuvant.
Prescription: the Radix Astragali 60 grams, Poria 60 grams, Rhizoma Dioscoreae 90 grams,
Fructus Ligustri Lucidi 36 grams, Fructus Corni 45 grams, mashed carrot 400 grams.
Mel 120 grams, rice vinegar 60 grams, sucrose 60 grams.
Method for making: Poria, Rhizoma Dioscoreae are pulverized, filter, the Radix Astragali, Fructus Ligustri Lucidi, Fructus Corni are washed the deionized water that adds 10 times of amounts to be soaked to boil after 30 minutes and carries 3 times, each 1 hour, merge decoction liquor, filtration, medicinal liquid evaporation and concentration to 300ml, add rice vinegar, multitudinous sugar, boil after-filtration, filtrate and medicated powder, mashed carrot mix homogeneously, subsequent technique is with embodiment 2-1.
Embodiment 2-3 Fructus Lycii electuary
Prescription: Fructus Lycii 150 grams, Radix Dauci Sativae powder 300 grams, cane sugar powder 100 grams, dextrin 50 grams
Method for making: Fructus Lycii is washed, and the deionized water that adds 10 times of amounts soaks to boil after 30 minutes carries 3 times, each 1 hour, merge and to boil decocting liquid, be concentrated into 50ml after the filtration, the Radix Dauci Sativae powder that will produce according to embodiment a, sucrose, dextrin and medicinal liquid mixed pelletization, dry getting final product.
The happy gourmet's luck calcium of Embodiment B-4 sugar-tablet
Prescription: calcium gluconate 1000 grams, Radix Dauci Sativae powder 2450 grams,
Cane sugar powder 500 grams, carboxymethyl starch sodium 2 grams,
Magnesium stearate 5 grams, 10% starch slurry, 50 grams.
Method for making: calcium gluconate, Radix Dauci Sativae powder, cane sugar powder are added the starch slurry mixing granulation, and dry back adds magnesium stearate, and carboxymethyl starch sodium, mixing are pressed into 10,000.
Adopt the pharmaceutical preparation of this method preparation, owing to adopted Radix Dauci Sativae to improve the mouthfeel and the outward appearance of original pharmaceutical preparation as pharmaceutic adjuvant, make it to have more the system of food, make patient be easy to adhere to taking for a long time, in addition, because the method that has adopted the degassing of vacuum heat and pressure microgranule to pulverize, can destroy the interior pectin composition of cell wall, isolated cell of plant, make the suspendible medicinal liquid utilize the pectin of self to keep stable, simultaneously, being of value to patient's absorption again has synergism for treatment.
Claims (4)
1, a kind of with the medicament preparation method of Radix Dauci Sativae as pharmaceutical necessities, this method comprises two steps of a, b,
The preparation of a, Radix Dauci Sativae excipient
Immerse immediately after the Radix Dauci Sativae fragmentation and prevent in 1% saline or 0.5% citric acid that enzyme from becoming, under 95-100 ℃ of condition ripening 8-12 minute, finish grind 50-100 μ m and become the mud shape, at 85-90 ℃, abnormal flavour is removed in the degassing under the vacuum 0.08-0.09MPa condition, under 10-25MPa pressure, carry out high pressure homogenize and handle the mashed carrot that obtains content 20-40%, or spray drying is standby;
B, excipient mix with drug extract, make with suspensoid, electuary or the tablet of Radix Dauci Sativae as pharmaceutical necessities, and the percentage by weight that adds Radix Dauci Sativae in pharmaceutical preparation is 20-80%.
2, according to claim 1 with the medicament preparation method of Radix Dauci Sativae as pharmaceutical necessities, it is characterized in that the mashed carrot before the degassing among a of drug extract and claim 1 is mixed adding acidic flavoring agent, sweeting agent, under claim 1a condition, outgas again, obtain stable pulp shape mixed suspension preparation behind the high pressure homogenize.
3, Radix Dauci Sativae according to claim 1 is as the medicament preparation method of pharmaceutical necessities, it is characterized in that the dry extract or the medicated powder of drug extract are mixed with the Radix Dauci Sativae powder of process spray drying treatment, the sucrose of adding, acidic flavoring agent, binding agent are granulated and are got final product.
4, Radix Dauci Sativae according to claim 1 is as the medicament preparation method of pharmaceutical necessities, it is characterized in that the dry extract of drug extract or medicated powder are mixed an amount of disintegrating agent of adding, mixing granulation, tabletting with the Radix Dauci Sativae powder of handling through spraying promptly get tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91101137 CN1030038C (en) | 1991-03-07 | 1991-03-07 | Method for preparation of medicament by using carrot as auxiliary material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91101137 CN1030038C (en) | 1991-03-07 | 1991-03-07 | Method for preparation of medicament by using carrot as auxiliary material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1064410A CN1064410A (en) | 1992-09-16 |
| CN1030038C true CN1030038C (en) | 1995-10-18 |
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ID=4904974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91101137 Expired - Fee Related CN1030038C (en) | 1991-03-07 | 1991-03-07 | Method for preparation of medicament by using carrot as auxiliary material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1030038C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI300714B (en) * | 2001-04-27 | 2008-09-11 | Ajinomoto Kk | Immunopotentiators |
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1991
- 1991-03-07 CN CN 91101137 patent/CN1030038C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1064410A (en) | 1992-09-16 |
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