CN1194667C - Process for preparing superfine particles of Chinese medicine - Google Patents
Process for preparing superfine particles of Chinese medicine Download PDFInfo
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- CN1194667C CN1194667C CNB01114467XA CN01114467A CN1194667C CN 1194667 C CN1194667 C CN 1194667C CN B01114467X A CNB01114467X A CN B01114467XA CN 01114467 A CN01114467 A CN 01114467A CN 1194667 C CN1194667 C CN 1194667C
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- 239000003814 drug Substances 0.000 title claims abstract description 99
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- 238000004519 manufacturing process Methods 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 47
- 239000000463 material Substances 0.000 claims abstract description 44
- 239000008187 granular material Substances 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 15
- 238000010298 pulverizing process Methods 0.000 claims abstract description 15
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- 238000005550 wet granulation Methods 0.000 claims abstract description 6
- 239000012567 medical material Substances 0.000 claims description 38
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Abstract
The present invention relates to a treatment method for superfine Chinese medicine granules, which is characterized in that after being dried, Chinese medicinal decoction pieces are converted into superfine powders by a superfine pulverization technology, and then, prepared into granules. The present invention has the treatment processes that 1. Chinese medicinal materials are normalized; 2. the treated decoction pieces are classified and dried; 3. the medicinal materials become superfine powders with the size of 0.1 to 500 um by a superfine pulverizer; 4. granules of the size of 5 to 100 meshes are prepared by a dry granulation technology or a wet granulation technology; 5. after being sterilized without pollution, the granules are vacuumized or packed by gas filling into a finished product. The present invention not only maintains the characteristic of formula according to disease in the traditional decoction piece but also avoids the trouble of decoction and has the advantages of more effective components dissolved from medicine, good absorption and medicinal material saving.
Description
The present invention relates to the processing technique of all kinds of Chinese medicine pharmaceutical decocting pieces, be specifically related to the processing technique that a kind of employing superfine communication technique is processed as the prepared slices of Chinese crude drugs granule.
Chinese medicine is China's " quintessence of Chinese culture ", and the traditional medicine culture has the theoretical system of system, unique diagnosis and treatment method, significant clinical efficacy, particularly doubts miscellaneous diseases for many difficulties, has its original therapeutic effect especially, occupies its unique status in the world.
The prepared slices of Chinese crude drugs are important means of middle medical drugs, along with development of times, and the progress of science and technology and the raising of people's drug level, the method for Chinese medicine " decoction pieces is used as medicine, faces with frying in shallow oil soup " shows its " inconvenience " and " uncertainty " day by day.At first, need interim the decoction before taking, time-consuming, patient is difficult to adhere to taking, and affects the treatment, and uses and carries very inconvenient.Secondly, some decoction pieces processing is concocted lack of standardization, and decoction pieces is not only thick but also big, can cause medicine active ingredient dissolution rate low when boiling, and the medical material utilization rate is low, and consumption is big, has caused the significant wastage of herb resource.Moreover, because the prepared slices of Chinese crude drugs lack strict quality control standard, to gather, processing is all lack of standardization, divides agent by experience during prescription, dosage is difficult to accurately, and quality is very unstable.
At present, the Chinese medicine market of progressively going to the world, China aspect the processing of Chinese medicine medical material and other surrounding countries also to some extent to the prepared slices of Chinese crude drugs processing study and improve, but all have certain deficiency.Though easy to use as the single medicinal material water preparation, because having ignored Chinese medicine decoction group's medicine, it fries in shallow oil altogether the influencing each other of some drugs active component stripping quantity, taken antiseptic when taking medicine again inevitably, thereby fail to promote the use of; Though the granule decoction pieces helps the efficacy component stripping, reduce the medical material consumption, but still need to decoct, take inconvenience, and volatile component loses easily, easy gelatinizing when the more medical material of starch-containing matter decocts will cause the medicinal liquid muddiness, filtration difficulty; Be not damaged and lose though the single medicinal material concentrated granular has been guaranteed in the medicine multiple components, has active ingredient concentration height, oral consumption is little, need not to decoct, dissolving rapidly, characteristics such as rapid-action, but since it passed through extraction, concentrated, chemical process such as drying, workload is big, and the cycle is long, simultaneously, medical material close fry in shallow oil with singly fry in shallow oil in effective component content difference to some extent, relevant pharmacodynamics index also is not quite similar, and with the contradictory part of the pertinent regulations of Medicine Act, thereby apply and have certain limitation.
Nineteen nineties, processing has brought gratifying variation to the prepared slices of Chinese crude drugs in the appearance of machine for decocting Chinese traditional herb medicines, it can bring into play the inherent advantage of decoction fully, and fried abundant, volatile ingredient unlikely loss in close property container, medicine is aseptic, pollution-free, concentration is even, the taking convenience health, but for some special handling of decoction as being decocted first, being difficult to accomplish under the back.
The objective of the invention is to overcome the defective of above-mentioned prior art, a kind of characteristic that had both kept traditional decoction pieces is provided, can face the disease prescription, can avoid the trouble that decocts again, and medicine stripping active ingredient is many, good absorbing, and curative effect is fast, save medical material, be applicable to prepared slices of Chinese crude drugs processing method and technology that various variety classes medical materials are handled.
The objective of the invention is to realize by following technical scheme.It comprises the process of preparing Chinese medicine, drying, pulverizing, granulation, sterilization packaging step, it is characterized in that described drying process adopts the classification drying means, wherein do not contain the volatile oil medical material in mineral substance medical material and the plant medicine material and adopt normal temperature drying, animal medicinal material and plant class contain the more medical material of sugar and adopt lyophilization, contain the volatile oil medical material in the plant medicine material and adopt cold drying; Described disintegrating process is: adopt micronizing to be machined to the micropowders of 0.01～500 μ m size dried decoction pieces, wherein mineral substance medical material grinding particle size is 0.01～100 μ m; The animal medicinal material grinding particle size is between 0.5～200 μ m; Do not contain volatile oil pulverizing medicinal materials granularity in the plant medicine material between 0.5～200 μ m, contain volatile oil pulverizing medicinal materials granularity between 20～500 μ m, containing the more pulverizing medicinal materials granularity of sugar is 0.5～200 μ m; Described granulating process is: the granule of above-mentioned fine powder being made 5～100 order sizes, wherein general mineral substance medical material adopts does the formula of squeezing granulation, and its squeeze pressure is 1～3Mpa, and side seal power is 0.5～1.5Mpa, need add 2%～5% binding agent during granulation, granularity is 20～60 orders; Animal medicinal material adopts does the formula of squeezing granulation, and squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, and granularity is between 14～60 orders; Contain the volatile oil medical material in the plant medicine material and adopt the dried formula of squeezing to granulate, squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, and the back granularity of granulating is 20～60 orders; Do not contain the volatile oil medical material and contain the more plant medicine material of sugar and then adopt wet granulation, its baking temperature is 50 ℃～90 ℃, adds 50%～90% ethanol during granulation, and granularity is 14～60 orders.
The present invention compared with prior art has following technique effect:
1. the present invention is the major reform that the Chinese medicine decoction pieces is done, it is a kind of new-type traditional Chinese tablet, it changes on the basis of traditional " decoction made from powder " or " bag bubble " technological merit in suction, adopt micronizing, pulverize at low temperature, modern technologies such as dry granulation are processed into the ultra micro Chinese medicinal granule with Chinese crude drug, carry out pollution-free sterilization again, damp-prrof packing, the granule that this processing method is made can replace the Chinese medicine room prepared slices of Chinese crude drugs, can adapt to the needs that the dialectical opinion of Chinese medicine is controlled, facing disease adding simplifies sanction, prescription flexibly, need not decoct during use, directly can take in about 3～20 minutes with the boiled water immersion, the nature,taste and action that had both kept Chinese medicine, avoid the trouble that decocts again, made things convenient for patient to take, and economic health, quick and convenient.
2. the present invention is applied to modern advanced in the processing of Chinese medicine medical material, its superfine communication technique makes the ultra tiny efflorescence of Chinese medicine medical material, in the medicine of identical deal, its surface area obtains increasing, and can increase to attract speed and absorbtivity, improves curative effect of medication, the active ingredient dissolution is improved greatly, thereby improve the effective rate of utilization of natural resources of Chinese medicinal materials, can save medical material 1/2-2/3, help the sustainable development of herb resource.
3. the present invention adopts dried crowded formula granulation or wet granulation technique that ultra-micro powder directly is pressed into granule; powder size is superfine after having overcome micronizing; mobile poor; be inconvenient to the shortcoming packing, transport, use, not only instant packed, use, transportation, but also do not influence the leaching of medicine active ingredient.
4. the present invention adopts the pollution-free sterilization method can reduce the prepared slices of Chinese crude drugs to contain the bacterium number, and is easy and simple to handle; Vacuum-packed can make medicine have good barrier, its protection against the tide, anti-ly go mouldy, the quality guarantee period is much better than traditional decoction pieces.
5. raw material of the present invention adopts healthful Chinese crud drug, and by " Chinese pharmacopoeia, " concocted specification " standardize and concoct processing, its granule has all been formulated the standardization quality standard, comprise the electron-microscope scanning powder characteristics, main chemical TLC differentiates, fineness of powder, moisture content, microorganism is limited the quantity of and water, alcohol extract amount and TLC differentiate (containing finger printing), heavy metal, arsenic salt and the quantitative determination of non-healthful Chinese crud drug pesticide residues etc., all can reach the relevant requirements of international mainstream city field alignment medicine, create condition for entering the international market.
The present invention combines traditional Chinese medicine characteristic with modern technologies, filled up the blank of domestic and international prepared slices of Chinese crude drugs processing industry, not only significant to the development of Chinese medical theory, and promoted standardization, the standardization, scientific of Chinese medicine can strengthen Chinese medicine, Chinese patent medicine competitiveness in the international market greatly.
Description of drawings:
Fig. 1 is a technological process block-diagram of the present invention.
Below in conjunction with accompanying drawing in detail the present invention is described in detail.
In China's tcm field, the prepared slices of Chinese crude drugs occupy important status, are to form the dialectical material base of controlling of executing in the basis of decoction and the theory of Chinese medical science, and the extraction of the active ingredient of the prepared slices of Chinese crude drugs plays important effect to therapeutic effect.Along with the continuous development of traditional Chinese medical science Pharmaceutical, Chinese medicine is just progressively favored by many countries, thereby the processing technique level of Chinese medicine is also constantly improving.The present invention passes through at present existing prepared slices of Chinese crude drugs machining status, by the mode that traditional Chinese medicine characteristic is combined with modern science and technology, on its processing method and processing technique, carried out new reform, not only on the efficacy component utilization rate, still on curative effect, make things convenient for patient to take aspect and packed and transported, all carried out comprehensive consideration on the pot-life, thereby realized purpose of the present invention.
Concrete processing method of the present invention is: earlier drying is carried out in prepared slices of Chinese crude drugs classification, it comprises the 5767 flavor Chinese medicines of being collected in " the Chinese medicine voluminous dictionary " of in July, 1997 publication of the Shanghai People's Press, wherein plant medicine 4773 is distinguished the flavor of, animal kind medicine 740 flavors, 172 flavors such as the product of being processed into that mineral medicine 82 flavors and tradition are used as single medicinal material, adopt then that superfine communication technique is processed into micropowders with the prepared slices of Chinese crude drugs in the modern advanced, its superfine communication technique can adopt high velocity air bump method or vibrant pulverization method, grain size of micropowder after the processing reaches micron order, can be according to medicine different classes of, be ground into the ultra-micro powder of 0.01-500 μ m size, adopting dry method or wet granulation technique to make again can be instant packed, the granule of selling and carrying.
Processing technique of the present invention is based on that said method realizes.As shown in Figure 1, it comprises following process steps:
1. at first the Chinese medicine medical material is standardized and concoct processing, this is the basis of prepared slices of Chinese crude drugs processing, need be prepared with certain manufacturing process in early stage as some Chinese crude drug, has different curative effects after improving curative effect or preparation.Simultaneously, standardization processing is concocted has strict controlled quality standard, and it can guarantee the quality of Chinese patent medicine from the source.
2. will concoct processed tablets and carry out drying, before at this moment pulverizing must through operation, if drying is not saturating, then decoction pieces is difficult to be processed into powder, but its drying means then will carry out according to the difference of the internal organizational structure of medical material.The present invention has enumerated three kinds of different processing methods that dissimilar medical materials is taked, and only need adopt the method for normal temperature drying as the mineral substance medical material, does not contain the volatile oil medical material in the plant medicine material and also can adopt this seasoning; Animal medicinal material then need adopt cryodesiccated method decoction pieces could be parched; Containing the volatile oil medical material in the plant medicine material needs cold drying, contains the more medical material of sugar and adopts freeze-drying.
3. dried decoction pieces is utilized high velocity air impaction techniques or vibrant pulverization technology to be ground into the micropowders of 0.01～500 μ m size.General mineral substance medical material grinding particle size is 0.1～100 μ m; The animal medicinal material grinding particle size is between 0.5～200 μ m; Do not contain volatile oil pulverizing medicinal materials granularity in the plant medicine material between 0.5～200 μ m, contain volatile oil pulverizing medicinal materials granularity between 20～500 μ m, containing the more pulverizing medicinal materials granularity of sugar is 0.5～200 μ m.This powder exceeds conventional fineness more than 10 times, and the medicine surface area is increased, and absorption rate and absorbtivity increase, and curative effect is improved.Micronizing also can make plant medicine material cell wall breaking rate improve, and can pulverize at low temperatures, can avoid in the medicine active ingredient dissolution being improved greatly to the destruction of thermally labile effective ingredient, thereby improve the utilization rate of herb resource, save herb resource.
4. adopt granulation technique to make the granule of 5～100 order sizes above-mentioned micropowders.Superfine because of the powder size after the micronizing, mobile poor, the present invention adopts granulation technique that ultramicro powder directly is pressed into granule, and is not only instant packed, use, transport, but also do not influence the leaching of medicine active ingredient.The granule that the present invention adopts granulation technique to make can be set in 5～100 order magnitude range according to different types of medical material, general mineral substance medical material adopts to do and squeezes the formula granulation technique, squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, need add 2%～5% binding agent during granulation, make it be unlikely loose, its granularity is 20～60 orders; Animal medicinal material also adopts to do and squeezes the formula granulation technique, and squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, and granularity is at 14～60 granulation techniques, and squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, granularity is between 14～60 orders; Contain the volatile oil medical material in the plant medicine material and adopt the dried formula granulation technique that squeezes, squeeze pressure also is 1～3Mpa, side seal power 0.5～1.5Mpa, its granularity of back of granulating is 20～60 orders, do not contain the volatile oil medical material and contain the more plant medicine material of sugar and then adopt wet granulation technique, its baking temperature is 50 ℃～90 ℃, adds 50%～90% ethanol during granulation, and its granularity is 14～60 orders.
5. after granulating, adopt the pollution-free sterilization mode that medicine is carried out sterilization treatment, to improve its pot-life.The invention process two kinds of sterilization methods, the one, the ethylene oxide sterilizing method, it is a kind of gaseous sterilization mode commonly used, and it is strong to have penetration power, easy and simple to handle, the characteristics that can sterilize at normal temperatures, can not destroy the active ingredient of medicine, can from these medicines, dissipate when being exposed in the air, can not produce harm human body, the ethane via epoxyethane sterilization, ultramicro powder can be preserved 3 years and can not change its property of medicine.Another kind method is the microwave sterilizating method, and it is to utilize high-frequency electric field to make the polarization of material interior molecules, and the sterilization that heats up rapidly can make it to absorb microwave energy, and be converted into heat energy and kill bacteria during the microwave penetration material.Use the prepared slices of Chinese crude drugs of microwave sterilizating, contain the bacterium number and can reduce by 99%.
After the sterilization, the present invention adopts the mode of vacuum packaging or gas flush packaging, make medicine have good barrier (comprising oxygen, microorganism etc.), can reach moistureproof, anti-purpose of going mouldy, be much better than the general prepared slices of Chinese crude drugs, the active ingredient of some drugs is not volatile simultaneously, long shelf-life, and packaged form itself is durable firmly to be born certain pressure and have cushioning effect again, preserves, transportation is all more convenient.
The present invention does not need to decoct, and boiling water can be taken after brewing 3～20 minutes, both keeps Traditional medicine materical crude slice and granular pattern medicine materical crude slice be convenient to tcm clinical practice and fill a prescription with disease, boiling water is taken after mixing it with water, good absorbing, The advantage that curative effect is fast has remedied again the deficiencies such as its prescription, decoction trouble, has stronger market Competitiveness.
Claims (1)
1, a kind of Chinese medicine ultramicro powder processing technique comprises the process of preparing Chinese medicine, drying, pulverizing, granulation, sterilization packaging step, it is characterized in that:
Described drying process adopts classification dry, wherein do not contain the volatile oil medical material in mineral substance medical material and the plant medicine material and adopt normal temperature drying, animal medicinal material and plant class contain the more medical material of sugar and adopt lyophilization, contain the volatile oil medical material in the plant medicine material and adopt cold drying;
Described disintegrating process is: adopt micronizing to be machined to the micropowders of 0.01～500 μ m size dried decoction pieces, wherein mineral substance medical material grinding particle size is 0.01～100 μ m; The animal medicinal material grinding particle size is between 0.5～200 μ m; Do not contain volatile oil pulverizing medicinal materials granularity in the plant medicine material between 0.5～200 μ m, contain volatile oil pulverizing medicinal materials granularity between 20～500 μ m, containing the more pulverizing medicinal materials granularity of sugar is 0.5～200 μ m;
Described granulating process is: the granule of above-mentioned fine powder being made 5～100 order sizes, wherein general mineral substance medical material adopts does the formula of squeezing granulation, and its squeeze pressure is 1～3Mpa, and side seal power is 0.5～1.5Mpa, need add 2%～5% binding agent during granulation, granularity is 20～60 orders; Animal medicinal material adopts does the formula of squeezing granulation, and squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, and granularity is between 14～60 orders; Contain the volatile oil medical material in the plant medicine material and adopt the dried formula of squeezing to granulate, squeeze pressure is 1～3Mpa, side seal power 0.5～1.5Mpa, and the back granularity of granulating is 20～60 orders; Do not contain the volatile oil medical material and contain the more plant medicine material of sugar and then adopt wet granulation, its baking temperature is 50 ℃～90 ℃, adds 50%～90% ethanol during granulation, and granularity is 14～60 orders.
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| CNB01114467XA CN1194667C (en) | 2001-05-17 | 2001-05-17 | Process for preparing superfine particles of Chinese medicine |
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| CNB01114467XA CN1194667C (en) | 2001-05-17 | 2001-05-17 | Process for preparing superfine particles of Chinese medicine |
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