CN115501262A - Preparation method of bighead atractylodes rhizome ultrafine powder granular decoction pieces - Google Patents
Preparation method of bighead atractylodes rhizome ultrafine powder granular decoction pieces Download PDFInfo
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- 241000132012 Atractylodes Species 0.000 title claims abstract description 52
- 239000000843 powder Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 239000008187 granular material Substances 0.000 claims abstract description 43
- 238000001035 drying Methods 0.000 claims abstract description 26
- 238000004806 packaging method and process Methods 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 22
- 238000004140 cleaning Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 13
- 230000008569 process Effects 0.000 claims abstract description 10
- 241000092665 Atractylodes macrocephala Species 0.000 claims description 13
- 238000002791 soaking Methods 0.000 claims description 11
- 239000007779 soft material Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 6
- 239000011888 foil Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 239000012535 impurity Substances 0.000 claims description 5
- 238000003892 spreading Methods 0.000 claims description 5
- 230000007480 spreading Effects 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 230000000391 smoking effect Effects 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims 2
- 238000005520 cutting process Methods 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 9
- 238000004090 dissolution Methods 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 238000010923 batch production Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 32
- 239000003651 drinking water Substances 0.000 description 5
- 235000020188 drinking water Nutrition 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 238000009835 boiling Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- TYPSVDGIQAOBAD-DZGCQCFKSA-N Atractylone Chemical compound C([C@]1(C)C2)CCC(=C)[C@@H]1CC1=C2OC=C1C TYPSVDGIQAOBAD-DZGCQCFKSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005485 electric heating Methods 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000242 Abortion threatened Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000027530 Meniere disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000005985 Threatened Abortion Diseases 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 208000012876 acute enteritis Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- TYPSVDGIQAOBAD-UHFFFAOYSA-N atractylone Natural products C1C2(C)CCCC(=C)C2CC2=C1OC=C2C TYPSVDGIQAOBAD-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
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- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The invention discloses a preparation method of bighead atractylodes rhizome ultrafine powder granular decoction pieces, which comprises the steps of cleaning, slicing, drying, stir-frying, crushing, granulating and packaging. By adopting the preparation method, no excipient is added in the preparation process, all natural characteristics of the traditional Chinese medicinal materials can be effectively maintained, the preparation process of the bighead atractylodes rhizome ultrafine powder granular decoction pieces is standardized, the preparation process is simple, the process parameters are stable and easy to control, the prepared granular decoction pieces have the advantages of high dissolution speed, high dissolution amount and the like, can replace the traditional Chinese medicinal decoction pieces, can maintain the advantages of the traditional Chinese medicinal preparations for decoction and oral administration, have strong identity of the active ingredient content of the granules, are convenient to realize large-scale and large-batch production, are convenient to apply, and are suitable for popularization and use.
Description
Technical Field
The invention relates to the technical field of processing of traditional Chinese medicinal materials, and in particular relates to a preparation method of bighead atractylodes rhizome ultrafine powder granular decoction pieces.
Background
The white atractylodes rhizome is a perennial herb of the atractylodes of the Compositae, is a common important bulk traditional Chinese medicinal material, has the functions of reinforcing spleen and strengthening stomach, eliminating dampness Li Shuihe, arresting sweating and preventing abortion and the like, and is mainly used for spleen deficiency, anorexia, abdominal distension and diarrhea, phlegm and fluid retention and palpitation, edema, spontaneous perspiration and threatened abortion. The rhizome of Atractylodes macrocephala contains volatile oil, the main components of the oil are atractylone, atractylol, atractylenolide, etc., and the oil has certain curative effect on ascites due to cirrhosis, primary liver cancer, meniere's syndrome, chronic lumbago, acute enteritis, leukopenia, etc. Therefore, the application of the bighead atractylodes rhizome is very wide, and the bighead atractylodes rhizome is an important raw material of various Chinese patent medicine preparations besides the medicine used in a medical formula.
The traditional Chinese medicine granules are traditional Chinese medicine series products which are prepared by taking traditional Chinese medicine decoction pieces which meet processing specifications as raw materials through modern industrial extraction, concentration, drying and granulation, have the same functions, indications, properties and flavors as well as meridian tropism as the traditional Chinese medicine decoction pieces, and are used as a new decoction piece form to replace the traditional Chinese medicine decoction pieces for clinical treatment based on syndrome differentiation, addition and subtraction according to the symptoms and the signs. Compared with the traditional Chinese medicine decoction mode of 'decoction pieces are used as medicines and are decocted at present', the traditional Chinese medicine granules not only keep the medicinal efficacy of the original traditional Chinese medicine decoction pieces, but also do not need to be decocted, are convenient to carry, sanitary, safe and controllable in quality, can be increased or decreased according to symptoms, and accord with the fast-paced life style of modern people. At present, the traditional Chinese medicine granules prepared by different manufacturers have different drug effects due to inconsistent product quality prepared by different preparation processes. Therefore, in order to improve the quality of the traditional Chinese medicine decoction pieces, the traditional Chinese medicine granular decoction pieces which can replace the traditional Chinese medicine decoction pieces are provided, so that the prepared traditional Chinese medicine granular decoction pieces can fully exert the natural and specific treatment efficacy, and have far-reaching social significance.
Disclosure of Invention
The invention aims to solve the technical problems in the background art and provides a preparation method of traditional Chinese medicine granular decoction pieces, the traditional Chinese medicine granular decoction pieces prepared by the method can effectively keep all natural characteristics of the traditional Chinese medicine without adding any excipient, simultaneously have the advantages of high dissolution speed, high dissolution amount and the like, are used for replacing the traditional Chinese medicine decoction pieces, can keep the advantages of the traditional Chinese medicine decoction pieces for decoction and taking, and particularly relates to a preparation method of the bighead atractylodes rhizome superfine powder granular decoction pieces.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows: the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces comprises the steps of cleaning, slicing, drying, stir-frying, crushing, granulating and packaging, and specifically comprises the following steps:
(1) Cleaning: removing impurities from the detected qualified rhizoma atractylodis macrocephalae traditional Chinese medicinal material, and cleaning;
(2) Slicing: slicing the cleaned rhizoma atractylodis macrocephalae traditional Chinese medicinal materials into thick slices with the length range of 1-4 cm and the thickness range of 0.4-0.8 cm;
(3) And (3) drying: putting the cut flaky atractylodes macrocephala into a dryer for drying treatment until the water content is 8-15%;
(4) Frying: spreading honey-fried bran into a hot pot, adding dried Atractylodis rhizoma slices when smoking, parching until brown color appears and scorched smell escapes, taking out, and sieving to remove honey-fried bran to obtain bran-fried Atractylodis rhizoma;
(5) Crushing: adding the stir-fried white atractylodes rhizome stir-fried with bran into an ultrafine grinder for low-temperature ultrafine grinding to obtain white atractylodes rhizome powder;
(6) Granulating, namely adding drinking water into the crushed rhizoma atractylodis macrocephalae powder, uniformly stirring to prepare a soft material, then adding the soft material into a granulator screen to granulate and dry, and granulating to obtain rhizoma atractylodis macrocephalae granules with the required granularity;
(7) Packaging, namely packaging the bighead atractylodes rhizome granules in parts, subpackaging the bighead atractylodes rhizome granules by using soaking bags with the fine density of 200-300 meshes, wherein the weight of the bighead atractylodes rhizome granules in each bag is 1-3 g, then bagging, and hermetically packaging the subpackaged soaking bags by using aluminum foil bags to obtain granular decoction pieces.
Further, in the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces, in the slicing process in the step (2), the decoction pieces are cut into thick pieces with the length range of 2-3 cm and the thickness range of 0.4-0.6 cm.
Further, in the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces, hot air at the temperature of 80-90 ℃ is adopted for drying in the drying process in the step (3) until the water content is 8-12%.
Further, in the preparation method of the bighead atractylodes rhizome submicron powder granule decoction pieces, 1kg of honey-fried bran is added into 10kg of bighead atractylodes rhizome tablets in the frying process in the step (4).
Further, in the preparation method of the atractylodes macrocephala submicron powder granular decoction pieces, a superfine pulverizer is adopted in the pulverizing process in the step (5), and the superfine powder with the granularity of 500-800 meshes is pulverized at the temperature of-35-25 ℃.
Further, in the preparation method of the atractylodes macrocephala submicron powder granular decoction pieces, in the granulation process in the step (6), drinking water accounting for 35-55% of the weight of the crushed atractylodes macrocephala is added into the crushed atractylodes macrocephala powder, the mixture is uniformly stirred to prepare a soft material, the soft material is added into a granulator to be granulated by a sieve with 24-50 meshes, the drying is carried out at the temperature of 75-85 ℃, and the size stabilization is carried out to obtain the atractylodes macrocephala granules meeting the required granularity.
Compared with the prior art, the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces has the beneficial effects that: the granular decoction pieces prepared by the method have the advantages of high dissolution speed, high dissolution amount and the like, can replace the traditional Chinese medicine decoction pieces, can keep the advantages of common decoction and taking of the traditional Chinese medicine, have strong identity of the active ingredient content of the granules, are convenient to realize large-scale production, are convenient to apply and are suitable for popularization and use. Therefore, the preparation method of the invention has the following advantages:
1. no excipient is added in the preparation process, so that all natural characteristics of the traditional Chinese medicinal material are effectively maintained, and the components of the traditional Chinese medicinal material are not changed due to the processing process;
2. the low-temperature crushing process is adopted, so that the volatilization loss of volatile components of the medicine is reduced, the fineness of the superfine powder reaches 500-800 meshes, the dissolution speed and the dissolution amount of the active components are improved, the active components are easier to absorb by organisms, the treatment effect of the medicine is enhanced, and medicinal material resources and medicinal auxiliary material resources, particularly the resources of the traditional Chinese medicinal materials with scarce and scarce resources are saved.
3. The prepared granules are packaged in a metering mode, so that medicine taking is convenient according to a prescription, the granules can be decocted with other traditional Chinese medicinal materials, the advantage of taking the traditional Chinese medicine preparation by decoction is kept, the synergistic effect of decocting multiple traditional Chinese medicinal materials is favorably realized, and the curative effect is improved. The micropore soaking bag is matched, and can be decocted properly according to the requirements of single or compound medicines, the decocting time of the decoction pieces is shortened by more than 5 times compared with the decoction pieces with the traditional formula, and the content of the extract is higher than that of the traditional decoction pieces by more than 25 percent when the extract is detected by a method for determining the extract in 2020 edition of Chinese pharmacopoeia (tenth edition); the granules can also be directly mixed into suspension or soak solution, and the use is convenient.
4. The extraction and concentration are not carried out, so that manpower and materials are saved, the residue or pollution of harmful substances in the extraction process is avoided, and meanwhile, the loss of unknown effective components in the traditional Chinese medicinal materials is also prevented.
5. The product quality and the identity of the active ingredient content of the granules are strong, the mechanized and large-scale production is convenient to realize, and the advantages of safety, sanitation, convenient taking, carrying and blending are achieved; the aluminum foil outer packaging bag is adopted, so that the moisture can be effectively prevented, and the quality problems of discoloration, worm damage, mildew and the like caused by improper storage and preservation of the traditional Chinese medicine are avoided.
Detailed Description
In order to more fully explain the practice of the invention, reference will now be made to the following examples which are intended to be illustrative thereof. The examples are given solely for the purpose of illustration and are not intended to limit the scope of the invention.
Example 1:
the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces comprises the steps of cleaning, slicing, drying, stir-frying, crushing, granulating and packaging, and specifically comprises the following steps:
(1) Cleaning: removing impurities from the detected qualified rhizoma atractylodis macrocephalae traditional Chinese medicinal material, and cleaning;
(2) Slicing: slicing the cleaned rhizoma atractylodis macrocephalae traditional Chinese medicinal materials into thick slices with the length range of 1-2 cm and the thickness range of 0.6-0.8 cm;
(3) And (3) drying: drying sliced rhizoma Atractylodis Macrocephalae in a drier at 80 deg.C until water content is 15%;
(4) Frying: spreading honey-fried bran into a hot pot, adding 1kg of honey-fried bran into 10kg of white atractylodes rhizome slices, adding dried white atractylodes rhizome slices when the added honey-fried bran is smoked, frying until the white atractylodes rhizome slices are yellow brown and burnt odor escapes, taking out the white atractylodes rhizome slices, and screening the honey-fried bran to obtain white atractylodes rhizome fried with bran;
(5) Crushing: adding parched Atractylodis rhizoma stir-fried with bran into micronizer, controlling temperature at-35, micronizing at low temperature to obtain superfine powder with particle size of 500 mesh, and pulverizing to obtain Atractylodis rhizoma powder;
(6) Granulating, namely adding 35% of drinking water by weight into the crushed rhizoma atractylodis macrocephalae powder, uniformly stirring to prepare a soft material, then adding into a granulator, granulating by using a 24-mesh screen, drying at the temperature of 75 ℃, and finishing granules to obtain rhizoma atractylodis macrocephalae granules with the granularity of 24 meshes;
(7) Packaging, namely packaging the bighead atractylodes rhizome granules in parts, subpackaging the bighead atractylodes rhizome granules by using soaking bags with the fine density of 200 meshes, wherein the weight of the bighead atractylodes rhizome granules in each bag is 1g, then bagging, and hermetically packaging the subpackaged soaking bags by using aluminum foil bags to obtain granular decoction pieces.
The prepared granules meet the standards of traditional Chinese medicine decoction pieces and granular preparation in the 2020 th edition of Chinese pharmacopoeia (the tenth edition) by detection. When in use, the compound prescription granule can be prepared by using an electric heating boiling pot commonly used in the prior art and is decocted for 8 to 12 minutes.
Example 2:
the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces comprises the steps of cleaning, slicing, drying, stir-frying, crushing, granulating and packaging, and specifically comprises the following steps:
(1) Cleaning: removing impurities from the detected qualified rhizoma atractylodis macrocephalae traditional Chinese medicinal material, and cleaning;
(2) Slicing: slicing the cleaned rhizoma atractylodis macrocephalae traditional Chinese medicinal materials into thick slices with the length range of 2-3 cm and the thickness range of 0.4-0.6 cm;
(3) And (3) drying: drying sliced rhizoma Atractylodis Macrocephalae in a drier at 85 deg.C until water content is 12%;
(4) Frying: spreading the honey-fried bran into a hot pot, adding 1kg of honey-fried bran into 10kg of honey-fried bran according to the adding amount of the honey-fried bran, adding dried white atractylodes rhizome slices when the added honey-fried bran smokes, frying until the honey-fried bran is yellow brown and burnt odor escapes, taking out the honey-fried bran, and screening the honey-fried bran to obtain bran-fried white atractylodes rhizome;
(5) Crushing: adding parched Atractylodis rhizoma stir-fried with bran into micronizer, controlling temperature at-30, micronizing at low temperature to obtain superfine powder with particle size of 600 mesh, and pulverizing to obtain Atractylodis rhizoma powder;
(6) Granulating, namely adding 45% of drinking water by weight into the crushed rhizoma atractylodis macrocephalae powder, uniformly stirring to prepare a soft material, then adding into a granulator, granulating by using a 30-mesh screen, drying at 85 ℃, and finishing granules to obtain rhizoma atractylodis macrocephalae granules with the granularity of 30 meshes;
(7) Packaging, namely packaging the bighead atractylodes rhizome granules in parts, subpackaging the bighead atractylodes rhizome granules by using soaking bags with the fine density of 250 meshes, wherein the weight of the bighead atractylodes rhizome granules in each bag is 2g, then bagging, and hermetically packaging the subpackaged soaking bags by using aluminum foil bags to obtain granular decoction pieces.
The prepared granules conform to the standards of traditional Chinese medicine decoction pieces and granular preparation in 2020 th edition of Chinese pharmacopoeia (eleventh edition) by detection. When in use, the compound formula granules can be prepared by using a common electric boiling pot in the prior art and then are heated and decocted for 8-12 minutes.
Example 3:
the preparation method of the bighead atractylodes rhizome ultrafine powder granular decoction pieces comprises the steps of cleaning, slicing, drying, stir-frying, crushing, granulating and packaging, and specifically comprises the following steps:
(1) Cleaning: removing impurities from the detected qualified rhizoma atractylodis macrocephalae traditional Chinese medicinal material, and cleaning;
(2) Slicing: slicing the cleaned rhizoma atractylodis macrocephalae traditional Chinese medicinal materials into thick slices with the length range of 3-4 cm and the thickness range of 0.5-0.7 cm;
(3) And (3) drying: drying the cut sheet-shaped bighead atractylodes rhizome in a dryer by adopting hot air at the temperature of 90 ℃ until the water content is 8%;
(4) Frying: spreading honey-fried bran into a hot pot, adding 1kg of honey-fried bran into 10kg of white atractylodes rhizome slices, adding dried white atractylodes rhizome slices when the added honey-fried bran is smoked, frying until the white atractylodes rhizome slices are yellow brown and burnt odor escapes, taking out the white atractylodes rhizome slices, and screening the honey-fried bran to obtain white atractylodes rhizome fried with bran;
(5) Crushing: adding parched Atractylodis rhizoma parched with bran into micronizer, controlling temperature at-30, micronizing at low temperature to obtain superfine powder with particle size of 800 mesh, and pulverizing to obtain Atractylodis rhizoma powder;
(6) Granulating, namely adding 55% of drinking water by weight into the crushed rhizoma atractylodis macrocephalae powder, uniformly stirring to prepare a soft material, then adding into a granulator, granulating by using a 50-mesh screen, drying at 85 ℃, and finishing granules to obtain 50-mesh rhizoma atractylodis macrocephalae granules;
(7) Packaging, namely packaging the bighead atractylodes rhizome granules in parts, subpackaging the bighead atractylodes rhizome granules by using soaking bags with the fine density of 300 meshes, wherein the weight of the bighead atractylodes rhizome granules in each bag is 3g, then bagging, and hermetically packaging the subpackaged soaking bags by using aluminum foil bags to obtain granular decoction pieces.
The prepared granules meet the standards of traditional Chinese medicine decoction pieces and granular preparation in the 2020 th edition of Chinese pharmacopoeia (the tenth edition) by detection. When in use, the compound prescription granule can be prepared by using an electric heating boiling pot commonly used in the prior art and is decocted for 8 to 12 minutes.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention, and it will be understood by those skilled in the art that various changes and modifications may be made therein without departing from the spirit and scope of the invention.
Claims (6)
1. The preparation method of the bighead atractylodes rhizome ultrafine powder particle decoction pieces is characterized by comprising the following steps of: the preparation method comprises the steps of cleaning, slicing, drying, stir-frying, crushing, granulating and packaging, and specifically comprises the following steps:
(1) Cleaning: removing impurities from the detected qualified rhizoma atractylodis macrocephalae traditional Chinese medicinal material, and cleaning;
(2) Slicing: slicing the cleaned rhizoma atractylodis macrocephalae traditional Chinese medicinal materials into thick slices with the length range of 1-4 cm and the thickness range of 0.4-0.8 cm;
(3) And (3) drying: putting the cut flaky atractylodes macrocephala into a dryer for drying treatment until the water content is 8-15%;
(4) Frying: spreading honey-fried bran into a hot pot, adding dried Atractylodis rhizoma slices when smoking, parching until brown color appears and scorched smell escapes, taking out, and sieving to remove honey-fried bran to obtain bran-fried Atractylodis rhizoma;
(5) Crushing: adding the stir-fried white atractylodes rhizome stir-fried with bran into an ultrafine grinder for low-temperature ultrafine grinding to obtain white atractylodes rhizome powder;
(6) Granulating, namely adding purified water into the crushed rhizoma atractylodis macrocephalae powder, uniformly stirring to prepare a soft material, then adding a granulator screen for granulating and drying, and finishing granules to obtain rhizoma atractylodis macrocephalae granules with the granularity meeting the requirement;
(7) Packaging, namely packaging the bighead atractylodes rhizome granules in weight portions by using soaking bags with the density of 200-300 meshes, wherein the weight of the bighead atractylodes rhizome granules in each bag is 1-3 g, then packaging the granules again, and hermetically packaging the separately packaged soaking bags by using aluminum foil bags to obtain the granular decoction pieces.
2. The preparation method of the atractylodes macrocephala submicron powder granular decoction pieces as claimed in claim 1, which is characterized in that: and (3) cutting the slices into thick slices with the length range of 2-3 cm and the thickness range of 0.4-0.6 cm in the slicing process in the step (2).
3. The preparation method of the atractylodes macrocephala submicron powder granular decoction pieces as claimed in claim 1, which is characterized in that: in the drying process in the step (3), hot air with the temperature of 80-90 ℃ is adopted for drying until the water content is 8-12%.
4. The preparation method of the atractylodes macrocephala submicron powder granular decoction pieces as claimed in claim 1, which is characterized in that: in the frying process in the step (4), 1kg of honey-fried bran is added into the honey-fried bran according to the adding amount of 10kg of bighead atractylodes rhizome tablets.
5. The preparation method of the atractylodes macrocephala ultrafine powder particle decoction piece as claimed in claim 1, which is characterized in that: in the crushing process in the step (5), an ultrafine crusher is adopted, and the temperature is controlled to be-35 to-25 ℃, so that the ultrafine powder with the particle size of 500 to 800 meshes is crushed.
6. The preparation method of the atractylodes macrocephala submicron powder granular decoction pieces as claimed in claim 1, which is characterized in that: in the granulating process in the step (6), purified water accounting for 35-55% of the weight of the crushed rhizoma atractylodis macrocephalae powder is added into the crushed rhizoma atractylodis macrocephalae powder, the mixture is uniformly stirred to prepare a soft material, the soft material is added into a granulator to be granulated by a sieve with 24-50 meshes, the mixture is dried at the temperature of 75-85 ℃, and the rhizoma atractylodis macrocephalae granules meeting the required granularity are obtained after the granulation.
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|---|---|---|---|---|
| CN1386495A (en) * | 2001-05-17 | 2002-12-25 | 湖南省中医药研究院 | Process for preparing superfine particles of Chinese medicine |
| US20110104290A1 (en) * | 2008-06-12 | 2011-05-05 | Sicheng Chen | Compositions for reducing blood glucose level and uses thereof |
| CN106963799A (en) * | 2017-04-01 | 2017-07-21 | 山东省交通医院 | A kind of preparation technology of bighead atractylodes rhizome Ultramicro-powder |
| CN111700925A (en) * | 2020-06-23 | 2020-09-25 | 北京杏林药业有限责任公司 | Processing technology of bran-fried bighead atractylodes rhizome decoction pieces |
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|---|---|---|---|---|
| CN1386495A (en) * | 2001-05-17 | 2002-12-25 | 湖南省中医药研究院 | Process for preparing superfine particles of Chinese medicine |
| US20110104290A1 (en) * | 2008-06-12 | 2011-05-05 | Sicheng Chen | Compositions for reducing blood glucose level and uses thereof |
| CN106963799A (en) * | 2017-04-01 | 2017-07-21 | 山东省交通医院 | A kind of preparation technology of bighead atractylodes rhizome Ultramicro-powder |
| CN111700925A (en) * | 2020-06-23 | 2020-09-25 | 北京杏林药业有限责任公司 | Processing technology of bran-fried bighead atractylodes rhizome decoction pieces |
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Application publication date: 20221223 |