CN113751171A - Preparation method of traditional Chinese medicine superfine powder preparation - Google Patents
Preparation method of traditional Chinese medicine superfine powder preparation Download PDFInfo
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- CN113751171A CN113751171A CN202111071538.8A CN202111071538A CN113751171A CN 113751171 A CN113751171 A CN 113751171A CN 202111071538 A CN202111071538 A CN 202111071538A CN 113751171 A CN113751171 A CN 113751171A
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- chinese medicine
- traditional chinese
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- 239000003814 drug Substances 0.000 title claims abstract description 43
- 239000000843 powder Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 230000001954 sterilising effect Effects 0.000 claims abstract description 10
- 210000002421 cell wall Anatomy 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 9
- 238000004140 cleaning Methods 0.000 claims abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 7
- 238000007689 inspection Methods 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims abstract description 6
- 238000012545 processing Methods 0.000 claims abstract description 6
- 239000000047 product Substances 0.000 claims abstract description 4
- 239000011265 semifinished product Substances 0.000 claims abstract description 4
- 241000894006 Bacteria Species 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 238000010298 pulverizing process Methods 0.000 claims description 7
- 241000588724 Escherichia coli Species 0.000 claims description 6
- 241000607142 Salmonella Species 0.000 claims description 6
- 241001148470 aerobic bacillus Species 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- 210000004102 animal cell Anatomy 0.000 claims description 3
- 239000003833 bile salt Substances 0.000 claims description 3
- 230000001680 brushing effect Effects 0.000 claims description 3
- 229940099352 cholate Drugs 0.000 claims description 3
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 3
- 229910017052 cobalt Inorganic materials 0.000 claims description 3
- 239000010941 cobalt Substances 0.000 claims description 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 229910001385 heavy metal Inorganic materials 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 3
- 239000000575 pesticide Substances 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 238000007790 scraping Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000010008 shearing Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 abstract description 12
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 12
- 239000011707 mineral Substances 0.000 abstract description 12
- 238000000227 grinding Methods 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 210000004379 membrane Anatomy 0.000 abstract description 5
- 238000004090 dissolution Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 210000001156 gastric mucosa Anatomy 0.000 abstract description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 238000011161 development Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000007600 charging Methods 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C21/00—Disintegrating plant with or without drying of the material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
- B02C23/08—Separating or sorting of material, associated with crushing or disintegrating
- B02C23/14—Separating or sorting of material, associated with crushing or disintegrating with more than one separator
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a traditional Chinese medicine superfine powder preparation, which comprises the steps of raw material inspection, cleaning, slicing, processing, coarse crushing, superfine crushing, sterilization, semi-finished product inspection, subpackaging, finished product inspection and the like; the method can improve the central particle size of the primary material from 150-200 meshes of the traditional process to more than 300 meshes, and the cell wall breaking rate under the fineness condition is more than 95 percent, so that the effective components in the primary material can be directly exposed, but the effective components are not released from cell walls (membranes), and the medicine can take effect more quickly and fully; after the traditional Chinese medicine is subjected to superfine grinding treatment, the granularity of the traditional Chinese medicine is finer and more uniform, the surface area is increased, the porosity is increased, the adsorbability and the solubility are enhanced, and the contact area with gastric mucosa is increased, so that the traditional Chinese medicine is easier to be absorbed by gastrointestinal tracts, and the bioavailability is greatly improved; a considerable part of mineral medicines are water-insoluble substances, and after being subjected to superfine grinding treatment, the particle size of the mineral medicines is greatly reduced, so that the dissolution and absorption speeds of the mineral medicines in a body can be accelerated, and the absorption capacity of the mineral medicines is improved.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of a traditional Chinese medicine superfine powder preparation.
Background
The traditional Chinese medicine is a characteristic of Chinese medical science and is a component of excellent culture in China. The traditional Chinese medicine is an important means for health care, prevention and treatment of the traditional Chinese medicine. In recent years, with the increasing importance of Chinese medicines in China and China, developed countries abroad have successively applied a great deal of advanced technical means to effectively transform the traditional Chinese medicine industry, and the mechanization, industrialization and modernization of Chinese medicine production are gradually realized.
In contrast, the development level of Chinese traditional medicine preparation is still a big gap, and the scientific and technological content in the production of Chinese traditional medicine is lower. To improve this situation, it is necessary to actively introduce advanced technologies to advance the modernization of development, development and production technologies, and to drive the adjustment of industrial structure by product and process technological innovation. The superfine grinding is a high and new technology which is rapidly developed in recent 20 years and can be used for processing raw materials into micron-level or even nano-level micro powder in the field of traditional Chinese medicines. In view of the fact that pulverization is a basic processing technology in traditional Chinese medicine production and application, superfine pulverization also attracts more and more attention, although development and development of varieties are relatively few after the start, specific advantages and wide application prospects are shown, and the superfine pulverization is a research hotspot in the traditional Chinese medicine field in recent years.
Disclosure of Invention
The invention aims to provide a preparation method of a traditional Chinese medicine superfine powder preparation, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a method for preparing Chinese medicinal superfine powder preparation comprises the following steps: inspecting raw materials, cleaning, slicing, processing, pulverizing, micronizing, sterilizing, inspecting semi-finished product, packaging, and inspecting finished product.
Preferably, the raw material inspection requirements are as follows: the raw materials are not damaged by worms and mildewed, the pollution of pesticides and heavy metals is avoided, the production area is reasonably roughly processed, and various links such as planting, digging and the like meet the GAP requirements.
Preferably, the cleaning method comprises the steps of sorting, screening, shearing, cutting, scraping, rejecting, brushing, wiping and soaking to meet the specified quality requirement.
Preferably, the coarse grinding is carried out by a high-power grinder and then passes through a 80-mesh screen to obtain coarse powder.
Preferably, the superfine grinding process comprises the following steps: transporting the coarse powder to a 30 ten thousand grade clean area, carrying out supersonic gas flow high-frequency vibration crushing, and screening by a 400-mesh screen after crushing to ensure that the diameter of particles is less than 50 mu m so as to break the wall of plant cell walls and animal cell membranes.
Preferably, the sterilization is cobalt radiation sterilization, and the sterilized bacteria include aerobic bacteria, mold and yeast, Escherichia coli, gram-negative bacteria resistant to bile salt, and salmonella; wherein the total number of aerobic bacteria is less than 0.5 × 104cfu/g, the total number of mould and microzyme is less than 0.5 × 102cfu/g, the detected amount of Escherichia coli is less than 1g, the detected amount of gram-negative bacteria resistant to cholate is less than 10cfu/g, and the detected amount of salmonella is less than 10 g.
Preferably, the subpackaging is carried out by weighing, subpackaging, sealing, labeling, punching and storing in a 30-ten-thousand-level clean area according to the subpackaging standard.
Has the advantages that: the invention has the beneficial effects that: the preparation method of the traditional Chinese medicine ultrafine powder preparation can improve the central particle size of the primary material from 150-200 meshes of the traditional process to more than 300 meshes, and for general medicinal materials, the cell wall breaking rate under the fineness condition is more than 95 percent, so that the effective components in the medicinal materials can be directly exposed, but not released from cell walls (membranes), and the effect of the medicinal materials is more rapid and sufficient; after the traditional Chinese medicine is subjected to superfine grinding treatment, the granularity of the traditional Chinese medicine is finer and more uniform, so that the surface area is increased, the porosity is increased, the adsorbability and the solubility are enhanced, the medicine can be well dispersed and dissolved in gastric juice, the contact area with gastric mucosa is increased, the medicine is more easily absorbed by gastrointestinal tracts, and the bioavailability is greatly improved; a considerable part of mineral medicines are water-insoluble substances, and after being subjected to superfine grinding treatment, the particle size of the mineral medicines is greatly reduced, so that the dissolution and absorption speeds of the mineral medicines in a body can be accelerated, and the absorption capacity of the mineral medicines is improved.
Detailed Description
In order that the objects, features and advantages of the present invention may be more clearly understood, the present invention will now be further described with reference to the following examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
Examples
A method for preparing Chinese medicinal superfine powder preparation comprises the following steps: inspecting raw materials, cleaning, slicing, processing, pulverizing, micronizing, sterilizing, inspecting semi-finished product, packaging, and inspecting finished product.
Further, the requirements of the raw material inspection are as follows: the raw materials are not damaged by worms and mildewed, the pollution of pesticides and heavy metals is avoided, the production area is reasonably roughly processed, and various links such as planting, digging and the like meet the GAP requirements.
Further, the cleaning method comprises the steps of sorting, screening, shearing, cutting, scraping, rejecting, brushing, wiping and soaking to meet the specified quality requirement.
Further, the coarse grinding is carried out by a high-power grinder and then passes through a 80-mesh screen to obtain coarse powder.
Further, the superfine grinding process comprises the following steps: transporting the coarse powder to a 30 ten thousand grade clean area, carrying out supersonic gas flow high-frequency vibration crushing, and screening by a 400-mesh screen after crushing to ensure that the diameter of particles is less than 50 mu m so as to break the wall of plant cell walls and animal cell membranes.
Further, the sterilization is cobalt radiation sterilization, and the sterilized bacteria include aerobic bacteria, mold and yeast, Escherichia coli, gram-negative bacteria resistant to bile salt, and salmonella; wherein the total number of aerobic bacteria is less than 0.5 × 104cfu/g, the total number of mould and microzyme is less than 0.5 × 102cfu/g, the detected amount of Escherichia coli is less than 1g, the detected amount of gram-negative bacteria resistant to cholate is less than 10cfu/g, and the detected amount of salmonella is less than 10 g.
Further, the split charging is carried out by weighing, split charging, sealing, labeling, punching and storing in a 30 ten thousand grade clean area according to the split charging standard.
The preparation method of the traditional Chinese medicine ultrafine powder preparation can improve the central particle size of the primary material from 150-200 meshes of the traditional process to more than 300 meshes, and for general medicinal materials, the cell wall breaking rate under the fineness condition is more than 95 percent, so that the effective components in the medicinal materials can be directly exposed, but not released from cell walls (membranes), and the effect of the medicinal materials is more rapid and sufficient; after the traditional Chinese medicine is subjected to superfine grinding treatment, the granularity of the traditional Chinese medicine is finer and more uniform, so that the surface area is increased, the porosity is increased, the adsorbability and the solubility are enhanced, the medicine can be well dispersed and dissolved in gastric juice, the contact area with gastric mucosa is increased, the medicine is more easily absorbed by gastrointestinal tracts, and the bioavailability is greatly improved; a considerable part of mineral medicines are water-insoluble substances, and after being subjected to superfine grinding treatment, the particle size of the mineral medicines is greatly reduced, so that the dissolution and absorption speeds of the mineral medicines in a body can be accelerated, and the absorption capacity of the mineral medicines is improved.
The embodiments described above are preferred embodiments of the present invention, and not all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (7)
1. A preparation method of a traditional Chinese medicine superfine powder preparation is characterized by comprising the following steps: inspecting raw materials, cleaning, slicing, processing, pulverizing, micronizing, sterilizing, inspecting semi-finished product, packaging, and inspecting finished product.
2. The method for preparing a superfine powder preparation of traditional Chinese medicine according to claim 1, wherein the raw material inspection requirements are as follows: the raw materials are not damaged by worms and mildewed, the pollution of pesticides and heavy metals is avoided, the production area is reasonably roughly processed, and various links such as planting, digging and the like meet the GAP requirements.
3. The method for preparing an ultrafine powder formulation of a Chinese medicinal material according to claim 1, wherein the cleaning comprises selecting, screening, shearing, cutting, scraping, rejecting, brushing, wiping, and soaking to achieve a predetermined quality.
4. The method for preparing an ultrafine powder formulation of a Chinese medicinal material according to claim 1, wherein the coarse pulverization is carried out by a high-power pulverizer, and the pulverized powder is passed through a 80-mesh sieve to obtain a coarse powder.
5. The method for preparing an ultrafine powder formulation of a Chinese medicinal material according to claim 1, wherein the micronization process comprises: transporting the coarse powder to a 30 ten thousand grade clean area, carrying out supersonic gas flow high-frequency vibration crushing, and screening by a 400-mesh screen after crushing to ensure that the diameter of particles is less than 50 mu m so as to break the wall of plant cell walls and animal cell membranes.
6. The method for preparing an ultrafine powder formulation of a Chinese medicinal material according to claim 1, wherein the sterilization is cobalt radiation sterilization, and the sterilized bacteria include aerobic bacteria, mold and yeast, Escherichia coli, gram-negative bacteria resistant to bile salt, Salmonella; wherein the total number of aerobic bacteria is less than 0.5 × 104cfu/g, the total number of mould and microzyme is less than 0.5 × 102cfu/g, the detected amount of Escherichia coli is less than 1g, the detected amount of gram-negative bacteria resistant to cholate is less than 10cfu/g, and the detected amount of salmonella is less than 10 g.
7. The method for preparing an ultrafine powder formulation of a traditional Chinese medicine according to claim 1, wherein the sub-packaging is performed by weighing, sub-packaging, sealing, labeling, packaging, and warehousing in a clean area of 30 ten thousand levels according to sub-packaging standards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111071538.8A CN113751171A (en) | 2021-09-14 | 2021-09-14 | Preparation method of traditional Chinese medicine superfine powder preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111071538.8A CN113751171A (en) | 2021-09-14 | 2021-09-14 | Preparation method of traditional Chinese medicine superfine powder preparation |
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| Publication Number | Publication Date |
|---|---|
| CN113751171A true CN113751171A (en) | 2021-12-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111071538.8A Pending CN113751171A (en) | 2021-09-14 | 2021-09-14 | Preparation method of traditional Chinese medicine superfine powder preparation |
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| Country | Link |
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| CN (1) | CN113751171A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115445738A (en) * | 2022-09-22 | 2022-12-09 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of micro-nano solid powder of whole Chinese herbal medicine root, stem and leaf plants and product thereof |
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|---|---|---|---|---|
| US20020114766A1 (en) * | 1998-12-01 | 2002-08-22 | Jean-Rene Authelin | Milling process for the production of finely milled medicinal substances |
| CN1386495A (en) * | 2001-05-17 | 2002-12-25 | 湖南省中医药研究院 | Process for preparing superfine particles of Chinese medicine |
| CN101147746A (en) * | 2006-09-18 | 2008-03-26 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
| CN104027250A (en) * | 2014-04-25 | 2014-09-10 | 江苏华冠生物技术股份有限公司 | Active release processing method for Chinese herbal medicine raw materials |
| CN106265521A (en) * | 2016-08-27 | 2017-01-04 | 广东罗浮山国药股份有限公司 | A kind of Chinese crude drug impalpable powder, the processing method of impalpable powder granule |
| CN106511400A (en) * | 2016-12-15 | 2017-03-22 | 湖南中健欣元生物科技有限公司 | Cell wall breaking method used for preparing medicinal material wall breaking powder |
-
2021
- 2021-09-14 CN CN202111071538.8A patent/CN113751171A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020114766A1 (en) * | 1998-12-01 | 2002-08-22 | Jean-Rene Authelin | Milling process for the production of finely milled medicinal substances |
| CN1386495A (en) * | 2001-05-17 | 2002-12-25 | 湖南省中医药研究院 | Process for preparing superfine particles of Chinese medicine |
| CN101147746A (en) * | 2006-09-18 | 2008-03-26 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
| CN104027250A (en) * | 2014-04-25 | 2014-09-10 | 江苏华冠生物技术股份有限公司 | Active release processing method for Chinese herbal medicine raw materials |
| CN106265521A (en) * | 2016-08-27 | 2017-01-04 | 广东罗浮山国药股份有限公司 | A kind of Chinese crude drug impalpable powder, the processing method of impalpable powder granule |
| CN106511400A (en) * | 2016-12-15 | 2017-03-22 | 湖南中健欣元生物科技有限公司 | Cell wall breaking method used for preparing medicinal material wall breaking powder |
Non-Patent Citations (3)
| Title |
|---|
| 吴皓: "《中药炮制学实验》", 30 April 2010 * |
| 国家药典委员会: "《中华人民共和国药典 2020年版》", 31 May 2020 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115445738A (en) * | 2022-09-22 | 2022-12-09 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of micro-nano solid powder of whole Chinese herbal medicine root, stem and leaf plants and product thereof |
| CN115445738B (en) * | 2022-09-22 | 2023-11-28 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of micro-nano solid powder of whole plant of root, stem and leaf of Chinese herbal medicine and product thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211207 |
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