CN109528903A - The preparation method of dye yam broken wall medicine materical crude slice with regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions and the dye yam broken wall medicine materical crude slice prepared by this method - Google Patents
The preparation method of dye yam broken wall medicine materical crude slice with regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions and the dye yam broken wall medicine materical crude slice prepared by this method Download PDFInfo
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Abstract
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical field, the dye yam broken wall medicine materical crude slice that discloses a kind of preparation method of the dye yam broken wall medicine materical crude slice with regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions and prepared by this method.Method includes the following steps: (1) is by dry dye yam medicinal material precomminution；(2) dye yam herb in granule form is soaked in ethanol water, is filtered, obtained filter cake is freeze-dried；(3) the dye yam particle obtained after freeze-drying is subjected to microwave treatment under vacuum conditions；(4) the dye yam particle obtained after microwave treatment is pulverized, it is 40 microns of micropowders below that the dye yam particle, which is crushed,；(5) it is that 50-60 weight % ethanol water mixes with concentration by the micropowders, is then pelletized and dried.The higher dye yam broken wall medicine materical crude slice of broken wall ratio can be made using method of the present invention.
Description
Technical field
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, and in particular to one kind has regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions
Dye yam broken wall medicine materical crude slice preparation method and by this method prepare dye yam broken wall medicine materical crude slice.
Background technique
Chinese medicine wall cell disruption medicine materical crude slice be with modern superfine communication technique by traditional medicine materical crude slice be process it is a kind of in powder form
The prepared slices of Chinese crude drugs being used as medicine.Chinese medicine wall cell disruption medicine materical crude slice is that full ingredient is used as medicine, and medical substance basis is constant, meets the intension of the prepared slices of Chinese crude drugs,
The nature and flavor of medicine materical crude slice and channel tropism after broken wall, function keep consistent with the tradition property of medicine materical crude slice with curing mainly etc., and broken wall medicine materical crude slice can be straight
It connects to brew and take, can be taken together with the dregs of a decoction.But medicine materical crude slice manufacturing enterprise applies not broken wall medicine materical crude slice technology at home at present
Extensively, real industry standard is not formed yet.Therefore, a kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice is researched and developed, sufficiently
The advantage that the full ingredient of Chinese medicine wall cell disruption medicine materical crude slice is used as medicine is played, whole effective components of traditional Chinese medicine are retained by broken wall, and then more sharp
In absorption of the user to effective component, is extracted with alleviating after existing Chinese medicine particle adds water to be concentrated, Chinese medicine part can only be extracted
The problem of effective component, becomes very necessary and urgent.
Dye yam (Dioscorea cirrhosa Lour.) is Dioscoreaceae, Dioscorea liana.It is distributed mainly on China
Southern Zhejiang, South Jiangxi, Fujian, Taiwan, Hunan, Guangdong, Guangxi, Guizhou, South Sichuan and western part, Yunnan, Motuo In Xizang.
Its stem tuber is rich in tannin, has promoting blood circulation and hemostasis, regulating qi-flowing for relieving pain, clearing heat and detoxicating and other effects.Being used as medicine can invigorate blood circulation, enrich blood, astringency inducing,
Control the diseases such as traumatic injury, stagnation of QI and blood, irregular menstruation, metrorrhagia, cough hemoptysis, hemianesthesia and rheumatism.However, at present also
Not about dye yam broken wall medicine materical crude slice and its report of preparation process.
Summary of the invention
The object of the present invention is to provide a kind of preparations of dye yam broken wall medicine materical crude slice with regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions
Method and the dye yam broken wall medicine materical crude slice prepared by this method.
The present invention provides a kind of preparation methods of dye yam broken wall medicine materical crude slice with regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions, should
Method the following steps are included:
It (1) is the particle of 50-100 mesh by dry dye yam medicinal material precomminution to granularity；
(2) dye yam herb in granule form is soaked in the ethanol water that concentration is 20-30 weight %, filtering, by what is obtained
Filter cake freeze-drying, the temperature of freeze-drying are -5 DEG C~-20 DEG C, vacuum degree 5-30Pa；
(3) the dye yam particle obtained after freeze-drying is subjected to microwave treatment under vacuum conditions；
(4) the dye yam particle obtained after microwave treatment is pulverized, it is 40 microns that the dye yam particle, which is crushed,
Micropowders below；
(5) it is that 50-60 weight % ethanol water mixes with concentration by the micropowders, is then pelletized and done
It is dry.
The present invention also provides the dye yam broken wall medicine materical crude slice prepared by the above method.
According to the preparation method of dye yam broken wall medicine materical crude slice of the present invention, dye yam medicinal material is subjected to precomminution first, then
It successively impregnated, be freeze-dried, stored frozen and microwave treatment, a whole set for the treatment of process in this way can be to the cell of dye yam
Wall carries out embrittlement, then can easily make dye yam breaking-wall cell by pulverizing, to obtain the higher potato of broken wall ratio
Liang broken wall medicine materical crude slice.Moreover, the product composition consistency of the dye yam broken wall medicine materical crude slice prepared according to the method described in the present invention is preferable, matter
Amount is stablized, is controllable, is conducive to modern big industrialized development significantly.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of dye yam broken wall medicine materical crude slice of the present invention the following steps are included:
It (1) is the particle of 50-100 mesh by dry dye yam medicinal material precomminution to granularity；
(2) dye yam herb in granule form is soaked in the ethanol water that concentration is 20-30 weight %, filtering, by what is obtained
Filter cake freeze-drying, the temperature of freeze-drying are -5 DEG C~-20 DEG C, vacuum degree 5-30Pa；
(3) the dye yam particle obtained after freeze-drying is subjected to microwave treatment under vacuum conditions；
(4) the dye yam particle obtained after microwave treatment is pulverized, it is 40 microns that the dye yam particle, which is crushed,
Micropowders below；
(5) it is that 50-60 weight % ethanol water mixes with concentration by the micropowders, is then pelletized and done
It is dry.
In step (1), by improving the specific surface area of dye yam medicinal material to dye yam medicinal material progress precomminution, thus
It is more advantageous to the embrittlement of the processes to dye yam cell wall such as subsequent immersion, freezing and microwave treatment.In the present invention, described pre-
The process of crushing is implemented using the grinding device of this field routine, and details are not described herein.
In method of the present invention, dye yam particle is impregnated using the ethanol water of 20-30 weight %, is had
Embrittlement is carried out conducive to dye yam cell wall, to help to obtain the dye yam broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, the condition of immersion may include: that temperature is 50-60 DEG C, and the time is 1-3 hours.
In the present invention, it by impregnating dye yam particle at a relatively high temperature, then carries out at very low temperature cold
Jelly processing is conducive to carry out embrittlement to dye yam cell wall in this way, thus favorably so that dye yam cell is exposed under the larger temperature difference
In the dye yam broken wall medicine materical crude slice for obtaining high sporoderm-broken rate.
In method of the present invention, during the immersion, the volume ratio of dye yam particle and ethanol water
It can be 1:3-8, more preferably 1:3-5.
In step (2), the condition of freeze-drying may include: that temperature is -5 DEG C~-20 DEG C, vacuum degree 5-30Pa.
Herein, vacuum degree refers to absolute pressure.
In step (2), filtering can use the strainer filtering of this field routine.In a particular embodiment, described
Strainer can be the stainless steel cloth that mesh size is 200 mesh.
In step (3), the condition of microwave treatment may include: that temperature is 10-40 DEG C, preferably 20-30 DEG C；Time is
30-60min, preferably 30-40min；The power of microwave is 5-20kW, preferably 10-20kW；Vacuum degree is 5-30Pa, preferably
For 10-20Pa.
In step (4), it is 40 microns or less (preferably 5- that the process of the ultramicro grinding, which crushes the dye yam particle,
40 microns, more preferably 5-30 microns) micropowders.Equipment used in pulverizing can be wall-broken grinder, such as
CW5-100QA broken wall micronizer.
In step (5), the mixing mass ratio of the micropowders and the ethanol water can be 1:0.5-0.7.
In step (5), the method for the drying can be contact drying, pneumatic conveying drying, tunnel type baking oven drying, vacuum
Drying, fluidized drying, freeze-drying, far-infrared ray drying or microwave drying.In the preferred case, the method for the drying is freezing
It is dry.
The present invention also provides the dye yam broken wall medicine materical crude slice prepared by the above method.
The present invention will be described in detail by way of examples below.
Embodiment 1
The dye yam medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 80 mesh, are subsequently added into 4 times of bodies of dye yam particle
The ethanol solution of 25 long-pending weight % impregnates 2 hours at 55 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -10 DEG C, under 20Pa vacuum degree.Obtained dye yam particle is placed under vacuum condition and carries out microwave treatment,
The condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 15Pa.Use CW5-
100QA broken wall micronizer pulverizes obtained dye yam particle, obtains the micropowders that granularity is 5-30 microns.
It with the ethanol water that concentration is 55 weight % is that 1:0.6 is mixed with weight ratio by the micropowders, extrusion granulator, so
It is freeze-dried at -10 DEG C, under 20Pa vacuum degree afterwards, so that dye yam broken wall medicine materical crude slice sample A1 be made.
Embodiment 2
The dye yam medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 100 mesh, are subsequently added into 5 times of bodies of dye yam particle
The ethanol solution of 28 long-pending weight % impregnates 3 hours at 52 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -10 DEG C, under 20Pa vacuum degree.Obtained dye yam particle is placed under vacuum condition and carries out microwave treatment,
The condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 15Pa.Use CW5-
100QA broken wall micronizer pulverizes obtained dye yam particle, obtains the micropowders that granularity is 5-30 microns.
It with the ethanol water that concentration is 52 weight % is that 1:0.5 is mixed with weight ratio by the micropowders, extrusion granulator, so
It is freeze-dried at -10 DEG C, under 20Pa vacuum degree afterwards, so that dye yam broken wall medicine materical crude slice sample A2 be made.
Embodiment 3
The dye yam medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 50 mesh, are subsequently added into 4 times of bodies of dye yam particle
The ethanol solution of 20 long-pending weight % impregnates 3 hours at 50 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -5 DEG C, under 5Pa vacuum degree.Obtained dye yam particle is placed under vacuum condition and carries out microwave treatment, it is micro-
The condition of wave processing are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 15Pa.Use CW5-
100QA broken wall micronizer pulverizes obtained dye yam particle, obtains the micropowders that granularity is 5-30 microns.
It with the ethanol water that concentration is 60 weight % is that 1:0.5 is mixed with weight ratio by the micropowders, extrusion granulator, so
It is freeze-dried at -5 DEG C, under 5Pa vacuum degree afterwards, so that dye yam broken wall medicine materical crude slice sample A3 be made.
Embodiment 4
The dye yam medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 80 mesh, are subsequently added into 5 times of bodies of dye yam particle
The ethanol solution of 24 long-pending weight % impregnates 2 hours at 56 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -5 DEG C, under 5Pa vacuum degree.Obtained dye yam particle is placed under vacuum condition and carries out microwave treatment, it is micro-
The condition of wave processing are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 15Pa.Use CW5-
100QA broken wall micronizer pulverizes obtained dye yam particle, obtains the micropowders that granularity is 5-30 microns.
It with the ethanol water that concentration is 58 weight % is that 1:0.8 is mixed with weight ratio by the micropowders, extrusion granulator, so
It is freeze-dried at -5 DEG C, under 5Pa vacuum degree afterwards, so that dye yam broken wall medicine materical crude slice sample A4 be made.
Embodiment 5
The dye yam medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 100 mesh, are subsequently added into 4 times of bodies of dye yam particle
The ethanol solution of 30 long-pending weight % impregnates 1 hour at 60 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree.Obtained dye yam particle is placed under vacuum condition and carries out microwave treatment,
The condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 15Pa.Use CW5-
100QA broken wall micronizer pulverizes obtained dye yam particle, obtains the micropowders that granularity is 5-30 microns.
It with the ethanol water that concentration is 50 weight % is that 1:0.7 is mixed with weight ratio by the micropowders, extrusion granulator, so
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree afterwards, so that dye yam broken wall medicine materical crude slice sample A5 be made.
Embodiment 6
The dye yam medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 80 mesh, are subsequently added into 5 times of bodies of dye yam particle
The ethanol solution of 26 long-pending weight % impregnates 2 hours at 58 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree.Obtained dye yam particle is placed under vacuum condition and carries out microwave treatment,
The condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 15Pa.Use CW5-
100QA broken wall micronizer pulverizes obtained dye yam particle, obtains the micropowders that granularity is 5-30 microns.
It with the ethanol water that concentration is 54 weight % is that 1:0.6 is mixed with weight ratio by the micropowders, extrusion granulator, so
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree afterwards, so that dye yam broken wall medicine materical crude slice sample A6 be made.
Comparative example 1
Dye yam broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that not implementing the work of ethanol water immersion
Sequence, so that dye yam broken wall medicine materical crude slice sample D1 be made.
Comparative example 2
Dye yam broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that replacing freezing with the mode of natural air drying
It is dry, so that dye yam broken wall medicine materical crude slice sample D2 be made.
Comparative example 3
Dye yam broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that not implementing the work of ethanol water immersion
Sequence, so that dye yam broken wall medicine materical crude slice sample D3 be made.
Comparative example 4
Dye yam broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that replacing freezing with the mode of natural air drying
It is dry, so that dye yam broken wall medicine materical crude slice sample D4 be made.
Comparative example 5
Dye yam broken wall medicine materical crude slice is prepared according to the method for embodiment 5, the difference is that not implementing the work of ethanol water immersion
Sequence, so that dye yam broken wall medicine materical crude slice sample D5 be made.
Comparative example 6
Dye yam broken wall medicine materical crude slice is prepared according to the method for embodiment 5, the difference is that replacing freezing with the mode of natural air drying
It is dry, so that dye yam broken wall medicine materical crude slice sample D6 be made.
Test case
The non-broken cells limit of dye yam broken wall medicine materical crude slice is tested with the following method: dye yam broken wall medicine materical crude slice 0.1g is taken,
Chloraldurate aqueous solution (volume ratio of chloraldurate test solution and water is 1:1) 10ml is added to be placed on glass slide, load is placed in micro-
Under the microscope, under 10 × 10 times of visuals field, greater than 100 microns and the powder number of complete cell is 0-5.Test result is such as
Shown in the following table 1.
Table 1
Can be seen that by the result of table 1 can be made the higher dye yam of broken wall ratio using method of the present invention
Broken wall medicine materical crude slice.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (6)
1. a kind of preparation method of the dye yam broken wall medicine materical crude slice with regulating qi-flowing for relieving pain and heat-clearing toxin-expelling functions, which is characterized in that the party
Method the following steps are included:
It (1) is the particle of 50-100 mesh by dry dye yam medicinal material precomminution to granularity；
(2) dye yam herb in granule form is soaked in the ethanol water that concentration is 20-30 weight %, filtering, the filter cake that will be obtained
Freeze-drying, the temperature of freeze-drying are -5 DEG C~-20 DEG C, vacuum degree 5-30Pa；
(3) the dye yam particle obtained after freeze-drying is subjected to microwave treatment under vacuum conditions；
(4) the dye yam particle obtained after microwave treatment is pulverized, it is 40 microns or less that the dye yam particle, which is crushed,
Micropowders；
(5) it is that 50-60 weight % ethanol water mixes with concentration by the micropowders, is then pelletized and dried.
2. the method according to claim 1, wherein the condition of immersion includes: that temperature is 50- in step (2)
60 DEG C, the time is 1-3 hours.
3. the method according to claim 1, wherein the condition of microwave treatment includes: temperature in step (3)
It is 10-40 DEG C, time 30-60min, the power of microwave is 5-20kW, vacuum degree 5-30Pa.
4. the method according to claim 1, wherein in step (5), the micropowders and the ethanol water
The mixing mass ratio of solution is 1:0.5-0.7.
5. the method according to claim 1, wherein the drying is freeze-drying in step (5).
6. the dye yam broken wall medicine materical crude slice of the preparation of the method as described in any one of claim 1-5.
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