CN109528826A - For treat the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain preparation method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom - Google Patents
For treat the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain preparation method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom Download PDFInfo
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Abstract
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, disclose a kind of preparation method for treating the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom.Method includes the following steps: (1) is by dry salvia bowleyana Dunn medicinal material precomminution；(2) gained salvia bowleyana Dunn herb in granule form is impregnated with ethanol water；(3) it filters, obtained filter cake is freeze-dried；(4) by Nandan ginseng grains after freeze-drying -10 DEG C~0 DEG C at a temperature of place 1-3 hours；(5) gained Nandan ginseng grains are placed under vacuum condition and carry out microwave treatment；(6) the Nandan ginseng grains after microwave treatment are pulverized；(7) gained micropowders are mixed with ethanol water, is then pelletized and is dried.The higher salvia bowleyana Dunn broken wall medicine materical crude slice of broken wall ratio can be made using method of the present invention.
Description
Technical field
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, and in particular to one kind is for treating thoracic obstruction colic pain and epigastric pain
Salvia bowleyana Dunn broken wall medicine materical crude slice preparation method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom.
Background technique
Chinese medicine wall cell disruption medicine materical crude slice be with modern superfine communication technique by traditional medicine materical crude slice be process it is a kind of in powder form
The prepared slices of Chinese crude drugs being used as medicine.Chinese medicine wall cell disruption medicine materical crude slice is that full ingredient is used as medicine, and medical substance basis is constant, meets the intension of the prepared slices of Chinese crude drugs,
The nature and flavor of medicine materical crude slice and channel tropism after broken wall, function keep consistent with the tradition property of medicine materical crude slice with curing mainly etc., and broken wall medicine materical crude slice can be straight
It connects to brew and take, can be taken together with the dregs of a decoction.But medicine materical crude slice manufacturing enterprise applies not broken wall medicine materical crude slice technology at home at present
Extensively, real industry standard is not formed yet.Therefore, a kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice is researched and developed, sufficiently
The advantage that the full ingredient of Chinese medicine wall cell disruption medicine materical crude slice is used as medicine is played, whole effective components of traditional Chinese medicine are retained by broken wall, and then more sharp
In absorption of the user to effective component, is extracted with alleviating after existing Chinese medicine particle adds water to be concentrated, Chinese medicine part can only be extracted
The problem of effective component, becomes very necessary and urgent.
Salvia bowleyana Dunn be Lamiaceae Salvia platymiscium salvia bowleyana Dunn Salvia bowleyana Dunn root, be distributed in Zhejiang,
The ground such as Jiangxi, Fujian, Hunan, Guangdong and Guangxi, main component are tanshinone, have the effect of activating microcirculation and removing stasis medicinal, menstruction regulating and pain relieving, main
Control thoracic obstruction colic pain, vexed, palpitaition, epigastric pain, irregular menstruation, dysmenorrhea, menostasis, postpartum stasis abdominal pain, metrorrhagia and metrostaxis, tripe splenomegaly,
Arthralgia, hernia pain, sore swells.However, there is presently no the reports about salvia bowleyana Dunn broken wall medicine materical crude slice and its preparation process.
Summary of the invention
The object of the present invention is to provide a kind of for treating the system of the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain
Preparation Method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom.
The present invention provides a kind of for treating the preparation method of the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain,
Method includes the following steps:
(1) by dry salvia bowleyana Dunn medicinal material precomminution, the salvia bowleyana Dunn herb in granule form that granularity is 10-100 mesh is obtained；
(2) the salvia bowleyana Dunn herb in granule form is impregnated with the ethanol water of 30-60 weight %, the condition of immersion includes: temperature
Degree is 40-60 DEG C, and the time is 1-3 hours；
(3) it filters, obtained filter cake is freeze-dried, the condition of freeze-drying includes: that temperature is -10 DEG C~-50 DEG C, very
Reciprocal of duty cycle is 5-50Pa；
(4) by Nandan ginseng grains after freeze-drying -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(5) gained Nandan ginseng grains are placed under vacuum condition and carry out microwave treatment；
(6) the Nandan ginseng grains after microwave treatment are pulverized, obtaining granularity is 40 microns below ultra tiny
Powder；
(7) micropowders are mixed with ethanol water, is then pelletized and is dried.
The present invention also provides the salvia bowleyana Dunn broken wall medicine materical crude slice prepared by the above method.
The beneficial effects of the present invention are:
According to the preparation method of salvia bowleyana Dunn broken wall medicine materical crude slice of the present invention, salvia bowleyana Dunn medicinal material is subjected to precomminution first,
Then it successively impregnated, be freeze-dried, stored frozen and microwave treatment, a whole set for the treatment of process in this way can be to salvia bowleyana Dunn
Cell wall carry out embrittlement, then by pulverize can easily make salvia bowleyana Dunn breaking-wall cell, to obtain broken wall ratio
Higher salvia bowleyana Dunn broken wall medicine materical crude slice.
Moreover, the product composition consistency of the salvia bowleyana Dunn broken wall medicine materical crude slice prepared according to the method described in the present invention is preferable, matter
Amount is stablized, is controllable, is conducive to modern big industrialized development significantly.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of salvia bowleyana Dunn broken wall medicine materical crude slice of the present invention the following steps are included:
(1) by dry salvia bowleyana Dunn medicinal material precomminution, the salvia bowleyana Dunn herb in granule form that granularity is 10-100 mesh is obtained；
(2) the salvia bowleyana Dunn herb in granule form is impregnated with the ethanol water of 30-60 weight %, the condition of immersion includes: temperature
Degree is 40-60 DEG C, and the time is 1-3 hours；
(3) it filters, obtained filter cake is freeze-dried, the condition of freeze-drying includes: that temperature is -10 DEG C~-50 DEG C, very
Reciprocal of duty cycle is 5-50Pa；
(4) by Nandan ginseng grains after freeze-drying -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(5) gained Nandan ginseng grains are placed under vacuum condition and carry out microwave treatment；
(6) the Nandan ginseng grains after microwave treatment are pulverized, obtaining granularity is 40 microns below ultra tiny
Powder；
(7) micropowders are mixed with ethanol water, is then pelletized and is dried.
In method of the present invention, after precomminution, the particle that is obtained after the salvia bowleyana Dunn pulverizing medicinal materials
It specifically, such as can be 10 mesh, 20 mesh, 30 mesh, 40 mesh, 50 mesh, 60 mesh, 70 mesh, 80 mesh, 90 mesh having a size of 10-100 mesh
Or 100 mesh.By carrying out precomminution to the salvia bowleyana Dunn medicinal material, the specific surface area of salvia bowleyana Dunn medicinal material is improved, to be more advantageous to
The embrittlement of the processes to salvia bowleyana Dunn cell wall such as subsequent immersion, freezing and microwave treatment.In the present invention, the precomminution
Process is implemented using the grinding device of this field routine, and details are not described herein.
In method of the present invention, the concentration for impregnate the ethanol water used to Nandan ginseng grains can
Think 30-60 weight %, specifically, such as can be 30 weight %, 35 weight %, 40 weight %, 45 weight %, 50 weights
Measure %, 55 weight % or 60 weight %.In the preferred case, the concentration of the ethanol water is 40-50 weight %.In this hair
In bright, Nandan ginseng grains are impregnated using the ethanol water of above-mentioned concentration, are conducive to carry out salvia bowleyana Dunn cell wall crisp
Change, to help to obtain the salvia bowleyana Dunn broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, the condition of immersion may include: that temperature is 40-60 DEG C of (such as 40 DEG C, 45 DEG C, 50
DEG C, 55 DEG C or 60 DEG C), the time be 1-3 hours (such as 1 hour, 1.5 hours, 2 hours, 2.5 hours or 3 hours).In the present invention
In, by impregnating Nandan ginseng grains at a relatively high temperature, freezing processing is then carried out at very low temperature,
So that salvia bowleyana Dunn cell is exposed under the larger temperature difference, be conducive to carry out embrittlement to salvia bowleyana Dunn cell wall in this way, to be conducive to
Obtain the salvia bowleyana Dunn broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, during the immersion, the volume of Nandan ginseng grains and ethanol water
Than that can be 1:2-10, preferably 1:3-8, more preferably 1:3-5.
In method of the present invention, the condition of freeze-drying may include: that temperature is -10 DEG C~-50 DEG C (such as -10
DEG C, -15 DEG C, -20 DEG C, -25 DEG C, -30 DEG C, -35 DEG C, -40 DEG C, -45 DEG C or -50 DEG C), vacuum degree be 5-50Pa (such as 5Pa,
10Pa, 20Pa, 30Pa, 40Pa or 50Pa).Herein, vacuum degree refers to absolute pressure.
In method of the present invention, filtering can use the strainer filtering of this field routine.In specific embodiment party
In formula, the strainer can be the stainless steel cloth that mesh size is 200 mesh.
In method of the present invention, the condition of microwave treatment may include: that temperature is 10-40 DEG C, preferably 20-30
℃；Time is 10-60min, preferably 20-40min；The power of microwave is 5-20kW, preferably 10-20kW；Vacuum degree is 5-
50Pa, preferably 10-20Pa.
In method of the present invention, it is preferable that the process of the ultramicro grinding, which crushes the salvia bowleyana Dunn particle, is
The micropowders of 40 microns or less (preferably 5-40 microns, more preferably 5-30 microns).Equipment used in pulverizing can
Wall-broken grinder is thought, such as CW5-100QA broken wall micronizer.
In step (7), the concentration of the ethanol water can be 60-80 weight %, specifically, such as can be 60
Weight %, 65 weight %, 70 weight %, 75 weight % or 80 weight %.
In step (7), the mixing mass ratio of the micropowders and the ethanol water is 1:0.3-1, preferably
1:0.5-0.7。
In step (7), the method for the drying can be contact drying, pneumatic conveying drying, tunnel type baking oven drying, vacuum
Drying, fluidized drying, freeze-drying, far-infrared ray drying or microwave drying.In the preferred case, the method for the drying is freezing
It is dry.
The present invention also provides the salvia bowleyana Dunn broken wall medicine materical crude slice prepared by the above method.
The present invention will be described in detail by way of examples below.
Embodiment 1
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 50 mesh, is subsequently added into 4 times of bodies of Nandan ginseng grains
The ethanol solution of 45 long-pending weight % impregnates 2 hours at 50 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with the ethanol water that concentration is 70 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -20 DEG C, under 30Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A1 be made.
Embodiment 2
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 4 times of Nandan ginseng grains
The ethanol solution of 35 weight % of volume impregnates 2 hours at 45 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -20 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with the ethanol water that concentration is 70 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -20 DEG C, under 30Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A2 be made.
Embodiment 3
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 80 mesh, is subsequently added into 4 times of bodies of Nandan ginseng grains
The ethanol solution of 55 long-pending weight % impregnates 2 hours at 55 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with the ethanol water that concentration is 70 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -20 DEG C, under 30Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A3 be made.
Embodiment 4
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 80 mesh, is subsequently added into 3 times of bodies of Nandan ginseng grains
The ethanol solution of 60 long-pending weight % impregnates 3 hours at 40 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -30 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with the ethanol water that concentration is 60 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -30 DEG C, under 20Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A4 be made.
Embodiment 5
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 3 times of Nandan ginseng grains
The ethanol solution of 35 weight % of volume impregnates 3 hours at 35 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -30 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with the ethanol water that concentration is 60 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -30 DEG C, under 20Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A5 be made.
Embodiment 6
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 50 mesh, is subsequently added into 3 times of bodies of Nandan ginseng grains
The ethanol solution of 55 long-pending weight % impregnates 3 hours at 55 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -30 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with the ethanol water that concentration is 60 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -30 DEG C, under 20Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A6 be made.
Embodiment 7
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 40 mesh, is subsequently added into 5 times of bodies of Nandan ginseng grains
The ethanol solution of 40 long-pending weight % impregnates 1 hour at 60 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -10 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -2 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with the ethanol water that concentration is 80 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -10 DEG C, under 10Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A7 be made.
Embodiment 8
(1) 2.0kg salvia bowleyana Dunn medicinal material is taken, precomminution to granularity is the particle of 60 mesh, is subsequently added into 5 times of bodies of Nandan ginseng grains
The ethanol solution of 55 long-pending weight % impregnates 3 hours at 60 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -10 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -2 DEG C after salvia bowleyana Dunn particle drying.
(2) the Nandan ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the Nandan ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with the ethanol water that concentration is 80 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -10 DEG C, under 10Pa vacuum degree, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample A8 be made.
Comparative example 1
Salvia bowleyana Dunn broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that not implementing ethanol water immersion
Process, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample D1 be made.
Comparative example 2
Salvia bowleyana Dunn broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made salvia bowleyana Dunn broken wall medicine materical crude slice sample D2.
Comparative example 3
Salvia bowleyana Dunn broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that salvia bowleyana Dunn broken wall medicine materical crude slice sample D3 be made.
Test case
The non-broken cells limit of salvia bowleyana Dunn broken wall medicine materical crude slice is tested with the following method: taking salvia bowleyana Dunn broken wall medicine materical crude slice
0.1g adds chloraldurate aqueous solution (volume ratio of chloraldurate test solution and water is 1:1) 10ml to be placed on glass slide, and load is set
In microscopically observation, under 10 × 10 times of visuals field, greater than 100 microns and the powder number of complete cell is 0-5.Test
As a result as shown in table 1 below.
Table 1
Can be seen that by the result of table 1 can be made the higher Nandan of broken wall ratio using method of the present invention
Join broken wall medicine materical crude slice.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (6)
1. a kind of for treating the preparation method of the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain, which is characterized in that should
Method the following steps are included:
(1) by dry salvia bowleyana Dunn medicinal material precomminution, the salvia bowleyana Dunn herb in granule form that granularity is 10-100 mesh is obtained；
(2) the salvia bowleyana Dunn herb in granule form is impregnated with the ethanol water of 30-60 weight %, the condition of immersion includes: that temperature is
40-60 DEG C, the time is 1-3 hours；
(3) it filters, obtained filter cake is freeze-dried, the condition of freeze-drying includes: that temperature is -10 DEG C~-50 DEG C, vacuum degree
For 5-50Pa；
(4) by Nandan ginseng grains after freeze-drying -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(5) gained Nandan ginseng grains are placed under vacuum condition and carry out microwave treatment；
(6) the Nandan ginseng grains after microwave treatment are pulverized, obtaining granularity is 40 microns of micropowders below；
(7) micropowders are mixed with ethanol water, is then pelletized and is dried.
2. the method according to claim 1, wherein it is 10-40 that the condition of the microwave treatment, which includes: temperature,
DEG C, time 10-60min, the power of microwave is 5-20kW, vacuum degree 5-50Pa.
3. the method according to claim 1, wherein in step (7), the concentration of the ethanol water is
60-80 weight %.
4. method according to claim 1 or 3, which is characterized in that in step (7), the micropowders and the second
The mixing mass ratio of alcohol solution is 1:0.3-1.
5. the method according to claim 1, wherein the drying is freeze-drying in step (7).
6. the salvia bowleyana Dunn broken wall medicine materical crude slice of the preparation of the method as described in any one of claim 1-5.
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| CN201811588323.1A CN109528826A (en) | 2018-12-25 | 2018-12-25 | For treat the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain preparation method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811588323.1A CN109528826A (en) | 2018-12-25 | 2018-12-25 | For treat the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain preparation method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102657782B (en) * | 2012-05-10 | 2013-09-18 | 日照市百满茶业有限公司 | Method for preparing medicinal tea for preventing upper respiratory tract infection |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
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2018
- 2018-12-25 CN CN201811588323.1A patent/CN109528826A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102657782B (en) * | 2012-05-10 | 2013-09-18 | 日照市百满茶业有限公司 | Method for preparing medicinal tea for preventing upper respiratory tract infection |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
Non-Patent Citations (1)
| Title |
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| 刘兴国等: "微波技术在中草药有效成分提取中的应用与发展 ", 《光明中医》 * |
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Application publication date: 20190329 |