CN109528872A - Have effects that the preparation method of the cayropteris incana broken wall medicine materical crude slice of antibacterial and cough-relieving and cayropteris incana broken wall medicine materical crude slice prepared therefrom - Google Patents
Have effects that the preparation method of the cayropteris incana broken wall medicine materical crude slice of antibacterial and cough-relieving and cayropteris incana broken wall medicine materical crude slice prepared therefrom Download PDFInfo
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Abstract
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical field, disclose a kind of cayropteris incana broken wall medicine materical crude slice with antibacterial and cough-relieving preparation method and cayropteris incana broken wall medicine materical crude slice prepared therefrom.Method includes the following steps: (1) takes dry cayropteris incana medicinal material, precomminution；(2) the cayropteris incana herb in granule form is soaked in the ethanol water of 30-60 weight %；(3) it filters, obtained filter cake is freeze-dried；(4) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；(5) obtained cayropteris incana particle is placed under vacuum condition and carries out microwave treatment, then pulverized；(6) obtained micropowders will be pulverized to mix with the ethanol water of 60-80 weight %, is then pelletized and is freeze-dried.The higher cayropteris incana broken wall medicine materical crude slice of broken wall ratio can be made using method of the present invention.
Description
Technical field
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, and in particular to a kind of cayropteris incana with antibacterial and cough-relieving
The preparation method of broken wall medicine materical crude slice and cayropteris incana broken wall medicine materical crude slice prepared therefrom.
Background technique
Chinese medicine wall cell disruption medicine materical crude slice be with modern superfine communication technique by traditional medicine materical crude slice be process it is a kind of in powder form
The prepared slices of Chinese crude drugs being used as medicine.Chinese medicine wall cell disruption medicine materical crude slice is that full ingredient is used as medicine, and medical substance basis is constant, meets the intension of the prepared slices of Chinese crude drugs,
The nature and flavor of medicine materical crude slice and channel tropism after broken wall, function keep consistent with the tradition property of medicine materical crude slice with curing mainly etc., and broken wall medicine materical crude slice can be straight
It connects to brew and take, can be taken together with the dregs of a decoction.But medicine materical crude slice manufacturing enterprise applies not broken wall medicine materical crude slice technology at home at present
Extensively, real industry standard is not formed yet.Therefore, a kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice is researched and developed, sufficiently
The advantage that the full ingredient of Chinese medicine wall cell disruption medicine materical crude slice is used as medicine is played, whole effective components of traditional Chinese medicine are retained by broken wall, and then more sharp
In absorption of the user to effective component, is extracted with alleviating after existing Chinese medicine particle adds water to be concentrated, Chinese medicine part can only be extracted
The problem of effective component, becomes very necessary and urgent.
Cayropteris incana is upright shrub, and main active component is cayropteris incana element sodium and cayropteris incana ketone, the function with antibacterial, cough-relieving
Effect.However, there is presently no the reports about cayropteris incana broken wall medicine materical crude slice and its preparation process.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of cayropteris incana broken wall medicine materical crude slice with antibacterial and cough-relieving and
Cayropteris incana broken wall medicine materical crude slice prepared therefrom.
The present invention provides a kind of preparation method of cayropteris incana broken wall medicine materical crude slice with antibacterial and cough-relieving and, this method
The following steps are included:
(1) dry cayropteris incana medicinal material is taken, precomminution obtains the cayropteris incana herb in granule form that granularity is 10-100 mesh；
(2) the cayropteris incana herb in granule form is soaked in the ethanol water of 30-60 weight %；
(3) it filters, obtained filter cake is freeze-dried；
(4) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(5) obtained cayropteris incana particle is placed under vacuum condition and carries out microwave treatment, then pulverized；
(6) obtained micropowders will be pulverized to mix with the ethanol water of 60-80 weight %, is then pelletized
And freeze-drying.
The present invention also provides the cayropteris incana broken wall medicine materical crude slice prepared by the above method.
According to the preparation method of cayropteris incana broken wall medicine materical crude slice of the present invention, cayropteris incana medicinal material is subjected to precomminution first,
Then it successively impregnated, be freeze-dried, stored frozen and microwave treatment, a whole set for the treatment of process in this way can be to cayropteris incana
Cell wall carry out embrittlement, then by pulverize can easily make cayropteris incana breaking-wall cell, to obtain broken wall ratio
Higher cayropteris incana broken wall medicine materical crude slice.
Moreover, the product composition consistency of the cayropteris incana broken wall medicine materical crude slice prepared according to the method described in the present invention is preferable, matter
Amount is stablized, is controllable, is conducive to modern big industrialized development significantly.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of cayropteris incana broken wall medicine materical crude slice of the present invention the following steps are included:
(1) dry cayropteris incana medicinal material is taken, precomminution obtains the cayropteris incana herb in granule form that granularity is 10-100 mesh；
(2) the cayropteris incana herb in granule form is soaked in the ethanol water of 30-60 weight %；
(3) it filters, obtained filter cake is freeze-dried；
(4) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(5) obtained cayropteris incana particle is placed under vacuum condition and carries out microwave treatment, then pulverized；
(6) obtained micropowders will be pulverized to mix with the ethanol water of 60-80 weight %, is then pelletized
And freeze-drying.
In method of the present invention, after precomminution, the particle that is obtained after the cayropteris incana pulverizing medicinal materials
It specifically, such as can be 10 mesh, 20 mesh, 30 mesh, 40 mesh, 50 mesh, 60 mesh, 70 mesh, 80 mesh, 90 mesh having a size of 10-100 mesh
Or 100 mesh.By carrying out precomminution to the cayropteris incana medicinal material, the specific surface area of cayropteris incana medicinal material is improved, to be more advantageous to
The embrittlement of the processes to cayropteris incana cell wall such as subsequent immersion, freezing and microwave treatment.In the present invention, the precomminution
Process is implemented using the grinding device of this field routine, and details are not described herein.
In method of the present invention, the concentration for impregnate the ethanol water used to cayropteris incana particle can
Think 30-60 weight %, specifically, such as can be 30 weight %, 35 weight %, 40 weight %, 45 weight %, 50 weights
Measure %, 55 weight % or 60 weight %.In the preferred case, the concentration of the ethanol water is 40-50 weight %.In this hair
In bright, cayropteris incana particle is impregnated using the ethanol water of above-mentioned concentration, is conducive to carry out cayropteris incana cell wall crisp
Change, to help to obtain the cayropteris incana broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, the condition of immersion may include: that temperature is 50-80 DEG C of (such as 50 DEG C, 60 DEG C, 70
DEG C or 80 DEG C), the time be 1-3 hours (such as 1 hour, 1.5 hours, 2 hours, 2.5 hours or 3 hours).In the present invention, lead to
Crossing impregnates cayropteris incana particle at a relatively high temperature, then carries out freezing processing at very low temperature, so that
Cayropteris incana cell is exposed under the larger temperature difference, is conducive to carry out embrittlement to cayropteris incana cell wall in this way, to help to obtain
The cayropteris incana broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, during the immersion, the volume of cayropteris incana particle and ethanol water
Than that can be 1:2-10, preferably 1:3-8, more preferably 1:3-5.
In method of the present invention, the condition of freeze-drying may include: that temperature is -10 DEG C~-50 DEG C (such as -10
DEG C, -15 DEG C, -20 DEG C, -25 DEG C, -30 DEG C, -35 DEG C, -40 DEG C, -45 DEG C or -50 DEG C), vacuum degree be 5-50Pa (such as 5Pa,
10Pa, 20Pa, 30Pa, 40Pa or 50Pa).Herein, vacuum degree refers to absolute pressure.
In method of the present invention, filtering can use the strainer filtering of this field routine.In specific embodiment party
In formula, the strainer can be the stainless steel cloth that mesh size is 200 mesh.
In method of the present invention, the condition of microwave treatment may include: that temperature is 10-40 DEG C, preferably 20-30
℃；Time is 10-60min, preferably 20-40min；The power of microwave is 5-20kW, preferably 10-20kW；Vacuum degree is 5-
50Pa, preferably 10-20Pa.
In method of the present invention, it is preferable that the process of the ultramicro grinding, which crushes the cayropteris incana particle, is
The micropowders of 40 microns or less (preferably 5-40 microns, more preferably 5-30 microns).Equipment used in pulverizing can
Wall-broken grinder is thought, such as CW5-100QA broken wall micronizer.
In step (6), it specifically, such as can be 60 weights that the concentration of the ethanol water, which is 60-80 weight %,
Measure %, 65 weight %, 70 weight %, 75 weight % or 80 weight %.
In step (6), the mixing mass ratio of the micropowders and the ethanol water is 1:0.3-1, preferably
1:0.5-0.7。
In step (6), the method for the drying can be contact drying, pneumatic conveying drying, tunnel type baking oven drying, vacuum
Drying, fluidized drying, freeze-drying, far-infrared ray drying or microwave drying.In the preferred case, the method for the drying is freezing
It is dry.
The present invention also provides the cayropteris incana broken wall medicine materical crude slice prepared by the above method.
The present invention will be described in detail by way of examples below.
Embodiment 1
(1) 2.0kg cayropteris incana medicinal material is taken, precomminution to granularity is the particle of 50 mesh, is subsequently added into 4 times of bodies of cayropteris incana particle
The ethanol solution of 45 long-pending weight % impregnates 2 hours at 70 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -20 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after cayropteris incana particle drying.
(2) the cayropteris incana particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the cayropteris incana particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with ethanol water that concentration is 70 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -20 DEG C, under 30Pa vacuum degree, so that cayropteris incana broken wall medicine materical crude slice sample be made
A1。
Embodiment 2
(1) 2.0kg cayropteris incana medicinal material is taken, precomminution to granularity is the particle of 80 mesh, is subsequently added into 3 times of bodies of cayropteris incana particle
The ethanol solution of 60 long-pending weight % impregnates 3 hours at 50 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -30 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after cayropteris incana particle drying.
(2) the cayropteris incana particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the cayropteris incana particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with ethanol water that concentration is 60 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -30 DEG C, under 20Pa vacuum degree, so that cayropteris incana broken wall medicine materical crude slice sample be made
A2。
Embodiment 3
(1) 2.0kg cayropteris incana medicinal material is taken, precomminution to granularity is the particle of 40 mesh, is subsequently added into 5 times of bodies of cayropteris incana particle
The ethanol solution of 40 long-pending weight % impregnates 1 hour at 80 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -10 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -2 DEG C after cayropteris incana particle drying.
(2) the cayropteris incana particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the cayropteris incana particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with ethanol water that concentration is 80 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -10 DEG C, under 10Pa vacuum degree, so that cayropteris incana broken wall medicine materical crude slice sample be made
A3。
Comparative example 1
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that not implementing ethanol water immersion
Process, so that cayropteris incana broken wall medicine materical crude slice sample D1 be made.
Comparative example 2
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made cayropteris incana broken wall medicine materical crude slice sample D2.
Comparative example 3
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that cayropteris incana broken wall medicine materical crude slice sample D3 be made.
Comparative example 4
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that not implementing ethanol water immersion
Process, so that cayropteris incana broken wall medicine materical crude slice sample D4 be made.
Comparative example 5
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made cayropteris incana broken wall medicine materical crude slice sample D5.
Comparative example 6
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that cayropteris incana broken wall medicine materical crude slice sample D6 be made.
Comparative example 7
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that not implementing ethanol water immersion
Process, so that cayropteris incana broken wall medicine materical crude slice sample D7 be made.
Comparative example 8
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made cayropteris incana broken wall medicine materical crude slice sample D8.
Comparative example 9
Cayropteris incana broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that cayropteris incana broken wall medicine materical crude slice sample D9 be made.
Test case
The non-broken cells limit of cayropteris incana broken wall medicine materical crude slice is tested with the following method: taking cayropteris incana broken wall medicine materical crude slice
0.1g adds chloraldurate aqueous solution (volume ratio of chloraldurate test solution and water is 1:1) 10ml to be placed on glass slide, and load is set
In microscopically observation, under 10 × 10 times of visuals field, greater than 100 microns and the powder number of complete cell is 0-5.Test
As a result as shown in table 1 below.
Table 1
| Embodiment number | Non- broken cells limit (a) |
| Embodiment 1 | 1 |
| Comparative example 1 | 8 |
| Comparative example 2 | 7 |
| Comparative example 3 | 9 |
| Embodiment 2 | 0 |
| Comparative example 4 | 7 |
| Comparative example 5 | 9 |
| Comparative example 6 | 7 |
| Embodiment 3 | 2 |
| Comparative example 7 | 7 |
| Comparative example 8 | 9 |
| Comparative example 9 | 8 |
Can be seen that by the result of table 1 can be made the higher blue perfume of broken wall ratio using method of the present invention
Careless broken wall medicine materical crude slice.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (7)
1. a kind of preparation method of the cayropteris incana broken wall medicine materical crude slice with antibacterial and cough-relieving, which is characterized in that including following step
It is rapid:
(1) dry cayropteris incana medicinal material is taken, precomminution obtains the cayropteris incana herb in granule form that granularity is 10-100 mesh；
(2) the cayropteris incana herb in granule form is soaked in the ethanol water of 30-60 weight %；
(3) it filters, obtained filter cake is freeze-dried；
(4) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(5) obtained cayropteris incana particle is placed under vacuum condition and carries out microwave treatment, then pulverized；
(6) obtained micropowders will be pulverized mix with the ethanol water of 60-80 weight %, then carry out pelletizing with it is cold
It is lyophilized dry.
2. the time is the method according to claim 1, wherein it is 50-80 DEG C that the condition impregnated, which includes: temperature,
1-3 hours.
3. method according to claim 1 or 2, which is characterized in that the condition of freeze-drying include: temperature be -10 DEG C~-
50 DEG C, vacuum degree 5-50Pa.
4. the method according to claim 1, wherein the condition of microwave treatment include: temperature be 10-40 DEG C, when
Between be 10-60min, the power of microwave is 5-20kW, vacuum degree 5-50Pa.
5. the method according to claim 1, wherein the process of the ultramicro grinding is by the cayropteris incana granular powder
Broken is 40 microns of micropowders below.
6. the method according to claim 1, wherein in step (6), the micropowders and the ethanol water
The mixing mass ratio of solution is 1:0.3-1.
7. the cayropteris incana broken wall medicine materical crude slice of the preparation of the method as described in any one of claim 1-6.
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|---|---|---|---|
| CN201811556783.6A CN109528872A (en) | 2018-12-19 | 2018-12-19 | Have effects that the preparation method of the cayropteris incana broken wall medicine materical crude slice of antibacterial and cough-relieving and cayropteris incana broken wall medicine materical crude slice prepared therefrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201811556783.6A CN109528872A (en) | 2018-12-19 | 2018-12-19 | Have effects that the preparation method of the cayropteris incana broken wall medicine materical crude slice of antibacterial and cough-relieving and cayropteris incana broken wall medicine materical crude slice prepared therefrom |
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| Publication Number | Publication Date |
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| CN109528872A true CN109528872A (en) | 2019-03-29 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102657782B (en) * | 2012-05-10 | 2013-09-18 | 日照市百满茶业有限公司 | Method for preparing medicinal tea for preventing upper respiratory tract infection |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
-
2018
- 2018-12-19 CN CN201811556783.6A patent/CN109528872A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102657782B (en) * | 2012-05-10 | 2013-09-18 | 日照市百满茶业有限公司 | Method for preparing medicinal tea for preventing upper respiratory tract infection |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
Non-Patent Citations (1)
| Title |
|---|
| 刘兴国等: "微波技术在中草药有效成分提取中的应用与发展 ", 《光明中医》 * |
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Application publication date: 20190329 |