CN109846837A - A kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery - Google Patents
A kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery Download PDFInfo
- Publication number
- CN109846837A CN109846837A CN201811572929.6A CN201811572929A CN109846837A CN 109846837 A CN109846837 A CN 109846837A CN 201811572929 A CN201811572929 A CN 201811572929A CN 109846837 A CN109846837 A CN 109846837A
- Authority
- CN
- China
- Prior art keywords
- rabdosia lophanthide
- broken wall
- crude slice
- materical crude
- medicine materical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, disclose a kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery.Method includes the following steps: (a) is by dry rabdosia lophanthide medicinal material precomminution；(b) particulate matter is impregnated with the first ethanol water；(c) filter, by obtained filter cake be freeze-dried, (d) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；(e) microwave treatment is carried out to obtained rabdosia lophanthide particle under vacuum conditions, is then pulverized；(f) gained micropowders are mixed with the second ethanol water, is then pelletized and is dried.The higher rabdosia lophanthide broken wall medicine materical crude slice of broken wall ratio can be made using method of the present invention.
Description
Technical field
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, and in particular to one kind is for treating acute icteric hepatitis, urgency
Property cholecystitis and the rabdosia lophanthide broken wall medicine materical crude slice of dysentery and preparation method thereof.
Background technique
Chinese medicine wall cell disruption medicine materical crude slice be with modern superfine communication technique by traditional medicine materical crude slice be process it is a kind of in powder form
The prepared slices of Chinese crude drugs being used as medicine.Chinese medicine wall cell disruption medicine materical crude slice is that full ingredient is used as medicine, and medical substance basis is constant, meets the intension of the prepared slices of Chinese crude drugs,
The nature and flavor of medicine materical crude slice and channel tropism after broken wall, function keep consistent with the tradition property of medicine materical crude slice with curing mainly etc., and broken wall medicine materical crude slice can be straight
It connects to brew and take, can be taken together with the dregs of a decoction.But medicine materical crude slice manufacturing enterprise applies not broken wall medicine materical crude slice technology at home at present
Extensively, real industry standard is not formed yet.Therefore, a kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice is researched and developed, sufficiently
The advantage that the full ingredient of Chinese medicine wall cell disruption medicine materical crude slice is used as medicine is played, whole effective components of traditional Chinese medicine are retained by broken wall, and then more sharp
In absorption of the user to effective component, is extracted with alleviating after existing Chinese medicine particle adds water to be concentrated, Chinese medicine part can only be extracted
The problem of effective component, becomes very necessary and urgent.
Rabdosia lophanthide (Rabdosia serra (Maxim.) Hara) is herbaceos perennial, is commonly called as wintergreen barberry root, cauline leaf
It can be used as medicine, main component is diterpene-kind compound, rabdosia lophanthide plain (including rabdosia lophanthide element A, B, D) and rabdosiaexcisa element, tool
There is the effect of clearing heat and promoting diuresis, removing jaundice clearing damp, cool blood dissipates the stasis of blood, for treating acute icteric hepatitis, acute cholecystitis, dysentery, intestines
The illnesss such as inflammation, bruise stasis caused pain.However, there is presently no the reports about rabdosia lophanthide broken wall medicine materical crude slice and its preparation process.
Summary of the invention
The object of the present invention is to provide a kind of for treating acute icteric hepatitis, acute cholecystitis and the rabdosia lophanthide of dysentery
Broken wall medicine materical crude slice and preparation method thereof.
The rabdosia lophanthide broken wall drink that the present invention provides a kind of for treating acute icteric hepatitis, acute cholecystitis and dysentery
The preparation method of piece, method includes the following steps:
(a) by dry rabdosia lophanthide medicinal material precomminution, the particle that granularity is 10-100 mesh is obtained；
(b) particulate matter is impregnated with the first ethanol water, the concentration of first ethanol water is 30-
60 weight %；
(c) it filters, obtained filter cake is freeze-dried,
(d) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(e) microwave treatment is carried out to obtained rabdosia lophanthide particle under vacuum conditions, is then pulverized, obtains 40
Micron micropowders below；
(f) micropowders are mixed with the second ethanol water, is then pelletized and is dried, second ethyl alcohol
The concentration of aqueous solution is 60-80 weight %.
The present invention also provides the rabdosia lophanthide broken wall medicine materical crude slice prepared by the above method.
According to the preparation method of rabdosia lophanthide broken wall medicine materical crude slice of the present invention, rabdosia lophanthide medicinal material is subjected to precomminution first,
Then it successively impregnated, be freeze-dried, stored frozen and microwave treatment, a whole set for the treatment of process in this way can be to rabdosia lophanthide
Cell wall carry out embrittlement, then by pulverize can easily make rabdosia lophanthide breaking-wall cell, to obtain broken wall ratio
Higher rabdosia lophanthide broken wall medicine materical crude slice.
Moreover, the product composition consistency of the rabdosia lophanthide broken wall medicine materical crude slice prepared according to the method described in the present invention is preferable, matter
Amount is stablized, is controllable, is conducive to modern big industrialized development significantly.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of rabdosia lophanthide broken wall medicine materical crude slice of the present invention the following steps are included:
(a) by dry rabdosia lophanthide medicinal material precomminution, the particle that granularity is 10-100 mesh is obtained；
(b) particulate matter is impregnated with the first ethanol water, the concentration of first ethanol water is 30-
60 weight %；
(c) it filters, obtained filter cake is freeze-dried,
(d) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(e) microwave treatment is carried out to obtained rabdosia lophanthide particle under vacuum conditions, is then pulverized, obtains 40
Micron micropowders below；
(f) micropowders are mixed with the second ethanol water, is then pelletized and is dried, second ethyl alcohol
The concentration of aqueous solution is 60-80 weight %.
In method of the present invention, after precomminution, the particle that is obtained after the rabdosia lophanthide pulverizing medicinal materials
It specifically, such as can be 10 mesh, 20 mesh, 30 mesh, 40 mesh, 50 mesh, 60 mesh, 70 mesh, 80 mesh, 90 mesh having a size of 10-100 mesh
Or 100 mesh.By carrying out precomminution to the rabdosia lophanthide medicinal material, the specific surface area of rabdosia lophanthide medicinal material is improved, to be more advantageous to
The embrittlement of the processes to rabdosia lophanthide cell wall such as subsequent immersion, freezing and microwave treatment.In the present invention, the precomminution
Process is implemented using the grinding device of this field routine, and details are not described herein.
In method of the present invention, rabdosia lophanthide particle is carried out to impregnate the dense of first ethanol water used
Degree can be 30-60 weight %, specifically, such as can be 30 weight %, 35 weight %, 40 weight %, 45 weight %, 50
Weight %, 55 weight % or 60 weight %.In the preferred case, the concentration of first ethanol water is 40-50 weight %.
In the present invention, rabdosia lophanthide particle is impregnated using the ethanol water of above-mentioned concentration, is conducive to rabdosia lophanthide cell wall
Embrittlement is carried out, to help to obtain the rabdosia lophanthide broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, the condition of immersion may include: that temperature is 50-80 DEG C of (such as 50 DEG C, 60 DEG C, 70
DEG C or 80 DEG C), the time be 1-3 hours (such as 1 hour, 1.5 hours, 2 hours, 2.5 hours or 3 hours).In the present invention, lead to
Crossing impregnates rabdosia lophanthide particle at a relatively high temperature, then carries out freezing processing at very low temperature, so that
Rabdosia lophanthide cell is exposed under the larger temperature difference, is conducive to carry out embrittlement to rabdosia lophanthide cell wall in this way, to help to obtain
The rabdosia lophanthide broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, during the immersion, the volume of rabdosia lophanthide particle and ethanol water
Than that can be 1:2-10, preferably 1:3-8, more preferably 1:3-5.
In method of the present invention, the condition of freeze-drying may include: that temperature is -10 DEG C~-50 DEG C (such as -10
DEG C, -15 DEG C, -20 DEG C, -25 DEG C, -30 DEG C, -35 DEG C, -40 DEG C, -45 DEG C or -50 DEG C), vacuum degree be 5-50Pa (such as 5Pa,
10Pa, 20Pa, 30Pa, 40Pa or 50Pa).Herein, vacuum degree refers to absolute pressure.
In method of the present invention, filtering can use the strainer filtering of this field routine.In specific embodiment party
In formula, the strainer can be the stainless steel cloth that mesh size is 200 mesh.
In method of the present invention, the condition of microwave treatment may include: that temperature is 10-40 DEG C, preferably 20-30
℃；Time is 10-60min, preferably 20-40min；The power of microwave is 5-20kW, preferably 10-20kW；Vacuum degree is 5-
50Pa, preferably 10-20Pa.
In method of the present invention, it is preferable that the process of the ultramicro grinding, which crushes the rabdosia lophanthide particle, is
The micropowders of 40 microns or less (preferably 5-40 microns, more preferably 5-30 microns).Equipment used in pulverizing can
Wall-broken grinder is thought, such as CW5-100QA broken wall micronizer.
In method of the present invention, the concentration of second ethanol water can be 60-80 weight %, specifically
Ground, such as can be 60 weight %, 65 weight %, 70 weight %, 75 weight % or 80 weight %.
In method of the present invention, the mixing mass ratio of the micropowders and second ethanol water is 1:
0.3-1, preferably 1:0.5-0.7.
In step (f), the method for the drying can be contact drying, pneumatic conveying drying, tunnel type baking oven drying, vacuum
Drying, fluidized drying, freeze-drying, far-infrared ray drying or microwave drying.In the preferred case, the method for the drying is freezing
It is dry.
The present invention also provides the rabdosia lophanthide broken wall medicine materical crude slice prepared by the above method.
The present invention will be described in detail by way of examples below.
Embodiment 1
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 50 mesh, is subsequently added into 4 times of bodies of rabdosia lophanthide particle
The ethanol solution of 45 long-pending weight % impregnates 2 hours at 70 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -20 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with ethanol water that concentration is 70 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -20 DEG C, under 30Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A1。
Embodiment 2
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 80 mesh, is subsequently added into 3 times of bodies of rabdosia lophanthide particle
The ethanol solution of 60 long-pending weight % impregnates 3 hours at 50 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -30 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with ethanol water that concentration is 60 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -30 DEG C, under 20Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A2。
Embodiment 3
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 40 mesh, is subsequently added into 5 times of bodies of rabdosia lophanthide particle
The ethanol solution of 40 long-pending weight % impregnates 1 hour at 80 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -10 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -2 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with ethanol water that concentration is 80 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -10 DEG C, under 10Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A3。
Embodiment 4
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 4 times of rabdosia lophanthide particle
The ethanol solution of 30 weight % of volume impregnates 3 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -25 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with ethanol water that concentration is 75 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -25 DEG C, under 30Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A4。
Embodiment 5
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 3 times of rabdosia lophanthide particle
The ethanol solution of 35 weight % of volume impregnates 3 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -35 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with ethanol water that concentration is 70 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -35 DEG C, under 20Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A5。
Embodiment 6
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 5 times of rabdosia lophanthide particle
The ethanol solution of 40 weight % of volume impregnates 3 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -20 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -2 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with ethanol water that concentration is 75 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -20 DEG C, under 10Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A6。
Embodiment 7
(1) 2.0kg rabdosia lophanthide medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 5 times of rabdosia lophanthide particle
The ethanol solution of 45 weight % of volume impregnates 3 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -15 DEG C, under 10Pa vacuum degree.It is placed 3 hours at 0 DEG C after rabdosia lophanthide particle drying.
(2) the rabdosia lophanthide particle that step (1) obtains is placed under vacuum condition and carries out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the rabdosia lophanthide particle that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with ethanol water that concentration is 65 weight % by the micropowders
It closes, then extrusion granulator is freeze-dried at -15 DEG C, under 10Pa vacuum degree, so that rabdosia lophanthide broken wall medicine materical crude slice sample be made
A7。
Comparative example 1
Rabdosia lophanthide broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that not implementing ethanol water immersion
Process, so that rabdosia lophanthide broken wall medicine materical crude slice sample D1 be made.
Comparative example 2
Rabdosia lophanthide broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made rabdosia lophanthide broken wall medicine materical crude slice sample D2.
Comparative example 3
Rabdosia lophanthide broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that rabdosia lophanthide broken wall medicine materical crude slice sample D3 be made.
Comparative example 4
Rabdosia lophanthide broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that not implementing ethanol water immersion
Process, so that rabdosia lophanthide broken wall medicine materical crude slice sample D4 be made.
Comparative example 5
Rabdosia lophanthide broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made rabdosia lophanthide broken wall medicine materical crude slice sample D5.
Comparative example 6
Rabdosia lophanthide broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that rabdosia lophanthide broken wall medicine materical crude slice sample D6 be made.
Test case
The non-broken cells limit of rabdosia lophanthide broken wall medicine materical crude slice is tested with the following method: taking rabdosia lophanthide broken wall medicine materical crude slice
0.1g adds chloraldurate aqueous solution (volume ratio of chloraldurate test solution and water is 1:1) 10ml to be placed on glass slide, and load is set
In microscopically observation, under 10 × 10 times of visuals field, greater than 100 microns and the powder number of complete cell is 0-5.Test
As a result as shown in table 1 below.
Table 1
| Embodiment number | Non- broken cells limit (a) |
| Embodiment 1 | 1 |
| Embodiment 2 | 2 |
| Embodiment 3 | 2 |
| Embodiment 4 | 2 |
| Embodiment 5 | 2 |
| Embodiment 6 | 3 |
| Embodiment 7 | 2 |
| Comparative example 1 | 9 |
| Comparative example 2 | 8 |
| Comparative example 3 | 9 |
| Comparative example 4 | 9 |
| Comparative example 5 | 9 |
| Comparative example 6 | 8 |
Can be seen that by the result of table 1 can be made the higher small stream Huang of broken wall ratio using method of the present invention
Careless broken wall medicine materical crude slice.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (7)
1. it is a kind of for treating the preparation method of the rabdosia lophanthide broken wall medicine materical crude slice of acute icteric hepatitis, acute cholecystitis and dysentery,
Characterized by comprising the following steps:
(a) by dry rabdosia lophanthide medicinal material precomminution, the particle that granularity is 10-100 mesh is obtained；
(b) particulate matter is impregnated with the first ethanol water, the concentration of first ethanol water is 30-60 weight
Measure %；
(c) it filters, obtained filter cake is freeze-dried,
(d) -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(e) microwave treatment is carried out to obtained rabdosia lophanthide particle under vacuum conditions, is then pulverized, obtains 40 microns
Micropowders below；
(f) micropowders are mixed with the second ethanol water, is then pelletized and is dried, second ethyl alcohol is water-soluble
The concentration of liquid is 60-80 weight %.
2. the time is the method according to claim 1, wherein it is 50-80 DEG C that the condition impregnated, which includes: temperature,
1-3 hours.
3. the method according to claim 1, wherein it is -10 DEG C~-50 that the condition of freeze-drying, which includes: temperature,
DEG C, vacuum degree 5-50Pa.
4. method described in any one of -3 according to claim 1, which is characterized in that the condition of microwave treatment includes: temperature
It is 10-40 DEG C, time 10-60min, the power of microwave is 5-20kW, vacuum degree 5-50Pa.
5. method described in any one of -3 according to claim 1, which is characterized in that in step (f), the micropowders
Mixing mass ratio with second ethanol water is 1:0.3-1.
6. method described in any one of -3 according to claim 1, which is characterized in that in step (f), the drying is cold
It is lyophilized dry.
7. the rabdosia lophanthide broken wall medicine materical crude slice of the preparation of the method as described in any one of claim 1-6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811572929.6A CN109846837A (en) | 2018-12-21 | 2018-12-21 | A kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811572929.6A CN109846837A (en) | 2018-12-21 | 2018-12-21 | A kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109846837A true CN109846837A (en) | 2019-06-07 |
Family
ID=66891838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811572929.6A Withdrawn CN109846837A (en) | 2018-12-21 | 2018-12-21 | A kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109846837A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
-
2018
- 2018-12-21 CN CN201811572929.6A patent/CN109846837A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101461852A (en) | Method for preparing super fine powder of rose | |
| CN109846837A (en) | A kind of rabdosia lophanthide broken wall medicine materical crude slice and preparation method thereof for treating acute icteric hepatitis, acute cholecystitis and dysentery | |
| CN109528858A (en) | It is a kind of for treating the Veronicastrum Herb broken wall medicine materical crude slice and preparation method thereof of cirrhotic ascites and nephritic dropsy | |
| CN109692192A (en) | The broken wall medicine materical crude slice for having effects that the preparation method of clearing heat and detoxicating, promoting blood circulation to remove blood stasis alangium broken wall medicine materical crude slice and being prepared by this method | |
| CN109846832A (en) | For treat the lance asiabell root broken wall medicine materical crude slice of spiritlessness and weakness and dizziness headache preparation method and lance asiabell root broken wall medicine materical crude slice prepared therefrom | |
| CN109568356A (en) | For treat the hyperici,herba broken wall medicine materical crude slice of rheumatism and dysentery preparation method and hyperici,herba broken wall medicine materical crude slice prepared therefrom | |
| CN109549962A (en) | The preparation method of Siberian cocklebur grass broken wall medicine materical crude slice with antispastic and analgesic efficacy and Siberian cocklebur grass broken wall medicine materical crude slice prepared therefrom | |
| CN109512856A (en) | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof | |
| CN109528872A (en) | Have effects that the preparation method of the cayropteris incana broken wall medicine materical crude slice of antibacterial and cough-relieving and cayropteris incana broken wall medicine materical crude slice prepared therefrom | |
| CN109602833A (en) | One seed ginseng potato broken wall medicine materical crude slice and preparation method thereof | |
| CN109528907A (en) | It is a kind of for treating the preparation method for curing mainly the careless river vehicle broken wall medicine materical crude slice of carbuncle swells tuberculosis chronic cough and careless river vehicle broken wall medicine materical crude slice prepared therefrom | |
| CN109528787A (en) | It is a kind of for curing cold, the HERBA BUPLEURI broken wall medicine materical crude slice of parotitis, tonsillitis and preparation method thereof | |
| CN109528873A (en) | For treat the Manyflower Gueldenstaedtid Herb broken wall medicine materical crude slice of jaundice, enteritis and dysentery preparation method and Manyflower Gueldenstaedtid Herb broken wall medicine materical crude slice prepared therefrom | |
| CN109528828A (en) | The preparation method of Cortex Cinnamomi broken wall medicine materical crude slice with calm, cooling and antihypertensive effect and Cortex Cinnamomi broken wall medicine materical crude slice prepared therefrom | |
| CN109846835A (en) | A kind of Bai Yun Shen broken wall medicine materical crude slice and preparation method thereof with strengthening the spleen and stomach, tonifying lung gas, expelling phlegm and arresting coughing | |
| CN111346206A (en) | Perilla frutescens, ginger and ginseng tea and preparation method thereof | |
| CN109602801A (en) | Have effects that the preparation method of the five fingers mandarin orange broken wall medicine materical crude slice of liver-smoothing, qi-regulating protecting the stomach and relieve the pain and the five fingers mandarin orange broken wall medicine materical crude slice prepared therefrom | |
| CN109846838A (en) | Have effects that the preparation method of the wallich swallowwort root broken wall medicine materical crude slice of Bu Shen Zhuang waist and strengthening the bones and muscles and wallich swallowwort root broken wall medicine materical crude slice prepared therefrom | |
| CN109528794A (en) | For treat the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis preparation method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom | |
| CN109846812A (en) | A kind of beauty treatment cosmetics and preparation method containing sea-buckthorn complex | |
| CN109528826A (en) | For treat the salvia bowleyana Dunn broken wall medicine materical crude slice of thoracic obstruction colic pain and epigastric pain preparation method and salvia bowleyana Dunn broken wall medicine materical crude slice prepared therefrom | |
| CN109528797A (en) | Have effects that the preparation method of clearing heat and detoxicating and inducing diuresis to remove edema elephants-foot broken wall medicine materical crude slice and elephants-foot broken wall medicine materical crude slice prepared therefrom | |
| CN109646473A (en) | For treating abundant expectoration, panting, not well, overstrain cough hemoptysis hempleaf groundsel herb broken wall medicine materical crude slice and preparation method thereof of coughing up phlegm | |
| CN104095203A (en) | Mangnolia-flavored wheat germ flour and preparation method thereof | |
| CN109568355A (en) | It is a kind of with Yin nourishing and lung moistening, cooling blood and hemostasis, the lichen broken wall medicine materical crude slice of heat-clearing toxin-expelling functions and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190607 |