CN109528794A - For treat the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis preparation method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom - Google Patents
For treat the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis preparation method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom Download PDFInfo
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Abstract
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, disclose a kind of preparation method for treating the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom.Method includes the following steps: (1) takes dry Cynanchum otophyllum Schneid medicinal material, precomminution to granularity is the particle of 10-100 mesh；(2) gained particulate matter is immersed in ethanol water, filter, by obtained filter cake be freeze-dried, then -10 DEG C~0 DEG C at a temperature of place；(3) gained Qingyang ginseng grains are placed under vacuum condition and carry out microwave treatment, then pulverized；(4) gained micropowders are mixed with the ethanol water of 60-80 weight %, is then pelletized and is dried.The higher Cynanchum otophyllum Schneid broken wall medicine materical crude slice of broken wall ratio can be made using method of the present invention.
Description
Technical field
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, and in particular to a kind of for treating the blueness of epilepsy and chronic hepatitis
The preparation method of sun ginseng broken wall medicine materical crude slice and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom.
Background technique
Chinese medicine wall cell disruption medicine materical crude slice be with modern superfine communication technique by traditional medicine materical crude slice be process it is a kind of in powder form
The prepared slices of Chinese crude drugs being used as medicine.Chinese medicine wall cell disruption medicine materical crude slice is that full ingredient is used as medicine, and medical substance basis is constant, meets the intension of the prepared slices of Chinese crude drugs,
The nature and flavor of medicine materical crude slice and channel tropism after broken wall, function keep consistent with the tradition property of medicine materical crude slice with curing mainly etc., and broken wall medicine materical crude slice can be straight
It connects to brew and take, can be taken together with the dregs of a decoction.But medicine materical crude slice manufacturing enterprise applies not broken wall medicine materical crude slice technology at home at present
Extensively, real industry standard is not formed yet.Therefore, a kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice is researched and developed, sufficiently
The advantage that the full ingredient of Chinese medicine wall cell disruption medicine materical crude slice is used as medicine is played, whole effective components of traditional Chinese medicine are retained by broken wall, and then more sharp
In absorption of the user to effective component, is extracted with alleviating after existing Chinese medicine particle adds water to be concentrated, Chinese medicine part can only be extracted
The problem of effective component, becomes very necessary and urgent.
Cynanchum otophyllum Schneid (Cynanchum otophyllum Schneid.) is grown on 1700-3000 meters of height above sea level of sparse woods hillside,
Liana, silver dollar column or coniform single life or lower forks are wound to life for perennial herbaceous stem, and grey black, leaf is to life, film quality, ovum
Shape lanceolar, base portion depth ear-lobe shape is heart-shaped, Hua Zise, rear thin out red or pale, Follicle fruit lanceolar or linear, seed oval
Shape, top have pale, and main component is the ingredients such as qingyangshengenin, the non-peaceful, vanillic acid of Ah spitting, and have heat-clearing cooling down, dispel
Wind, desinsection and other effects also have good therapeutic effect to treatment epilepsy and ductility, chronic hepatitis.However, there is presently no about Cynanchum otophyllum Schneid
The report of broken wall medicine materical crude slice and its preparation process.
Summary of the invention
The object of the present invention is to provide a kind of for treating the preparation side of the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis
Method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom.
The present invention provides a kind of for treating the preparation method of the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis, the party
Method the following steps are included:
(1) dry Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 10-100 mesh；
(2) gained particulate matter is immersed in the ethanol water of 30-60 weight %, is filtered, obtained filter cake is freezed
It is dry, then -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(3) gained Qingyang ginseng grains are placed under vacuum condition and carry out microwave treatment, then pulverized, obtain 40
Micron micropowders below；
(4) micropowders are mixed with the ethanol water of 60-80 weight %, is then pelletized and is dried.
The present invention also provides the Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared by the above method.
According to the preparation method of Cynanchum otophyllum Schneid broken wall medicine materical crude slice of the present invention, Cynanchum otophyllum Schneid medicinal material is subjected to precomminution first,
Then it successively impregnated, be freeze-dried, stored frozen and microwave treatment, a whole set for the treatment of process in this way can be to Cynanchum otophyllum Schneid
Cell wall carry out embrittlement, then by pulverize can easily make Cynanchum otophyllum Schneid breaking-wall cell, to obtain broken wall ratio
Higher Cynanchum otophyllum Schneid broken wall medicine materical crude slice.
Moreover, the product composition consistency of the Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared according to the method described in the present invention is preferable, matter
Amount is stablized, is controllable, is conducive to modern big industrialized development significantly.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of Cynanchum otophyllum Schneid broken wall medicine materical crude slice of the present invention the following steps are included:
(1) dry Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 10-100 mesh；
(2) gained particulate matter is immersed in the ethanol water of 30-60 weight %, is filtered, obtained filter cake is freezed
It is dry, then -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(3) gained Qingyang ginseng grains are placed under vacuum condition and carry out microwave treatment, then pulverized, obtain 40
Micron micropowders below；
(4) micropowders are mixed with the ethanol water of 60-80 weight %, is then pelletized and is dried.
In method of the present invention, after precomminution, the particle that is obtained after the Cynanchum otophyllum Schneid pulverizing medicinal materials
It specifically, such as can be 10 mesh, 20 mesh, 30 mesh, 40 mesh, 50 mesh, 60 mesh, 70 mesh, 80 mesh, 90 mesh having a size of 10-100 mesh
Or 100 mesh.By carrying out precomminution to the Cynanchum otophyllum Schneid medicinal material, the specific surface area of Cynanchum otophyllum Schneid medicinal material is improved, to be more advantageous to
The embrittlement of the processes to Cynanchum otophyllum Schneid cell wall such as subsequent immersion, freezing and microwave treatment.In the present invention, the precomminution
Process is implemented using the grinding device of this field routine, and details are not described herein.
In method of the present invention, the concentration for impregnate the ethanol water used to Qingyang ginseng grains can
Think 30-60 weight %, specifically, such as can be 30 weight %, 35 weight %, 40 weight %, 45 weight %, 50 weights
Measure %, 55 weight % or 60 weight %.In the preferred case, the concentration of the ethanol water is 40-50 weight %.In this hair
In bright, Qingyang ginseng grains are impregnated using the ethanol water of above-mentioned concentration, are conducive to carry out Cynanchum otophyllum Schneid cell wall crisp
Change, to help to obtain the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, the condition of immersion may include: that temperature is 50-80 DEG C of (such as 50 DEG C, 60 DEG C, 70
DEG C or 80 DEG C), the time be 1-3 hours (such as 1 hour, 1.5 hours, 2 hours, 2.5 hours or 3 hours).In the present invention, pass through
It impregnates Qingyang ginseng grains at a relatively high temperature, then carries out freezing processing at very low temperature, so that green
Sun ginseng cell is exposed under the larger temperature difference, is conducive to carry out embrittlement to Cynanchum otophyllum Schneid cell wall in this way, to help to obtain height
The Cynanchum otophyllum Schneid broken wall medicine materical crude slice of sporoderm-broken rate.
In method of the present invention, during the immersion, the volume of Qingyang ginseng grains and ethanol water
Than that can be 1:2-10, preferably 1:3-8, more preferably 1:3-5.
In method of the present invention, the condition of freeze-drying may include: that temperature is -10 DEG C~-50 DEG C (such as -10
DEG C, -15 DEG C, -20 DEG C, -25 DEG C, -30 DEG C, -35 DEG C, -40 DEG C, -45 DEG C or -50 DEG C), vacuum degree be 5-50Pa (such as 5Pa,
10Pa, 20Pa, 30Pa, 40Pa or 50Pa).Herein, vacuum degree refers to absolute pressure.
In method of the present invention, filtering can use the strainer filtering of this field routine.In specific embodiment party
In formula, the strainer can be the stainless steel cloth that mesh size is 200 mesh.
In method of the present invention, the condition of microwave treatment may include: that temperature is 10-40 DEG C, preferably 20-30
℃；Time is 10-60min, preferably 20-40min；The power of microwave is 5-20kW, preferably 10-20kW；Vacuum degree is 5-
50Pa, preferably 10-20Pa.
In method of the present invention, it is preferable that the process of the ultramicro grinding, which crushes the Cynanchum otophyllum Schneid particle, is
The micropowders of 40 microns or less (preferably 5-40 microns, more preferably 5-30 microns).Equipment used in pulverizing can
Wall-broken grinder is thought, such as CW5-100QA broken wall micronizer.
In step (4), the concentration of the ethanol water can be 60-80 weight %, specifically, such as can be 60
Weight %, 65 weight %, 70 weight %, 75 weight % or 80 weight %.
In step (4), the mixing mass ratio of the micropowders and the ethanol water is 1:0.3-1, preferably
1:0.5-0.7。
In step (4), the method for the drying can be contact drying, pneumatic conveying drying, tunnel type baking oven drying, vacuum
Drying, fluidized drying, freeze-drying, far-infrared ray drying or microwave drying.In the preferred case, the method for the drying is freezing
It is dry.
The present invention also provides the Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared by the above method.
The present invention will be described in detail by way of examples below.
Embodiment 1
(1) 2.0kg Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 50 mesh, is subsequently added into 4 times of bodies of Qingyang ginseng grains
The ethanol solution of 45 long-pending weight % impregnates 2 hours at 70 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -20 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -5 DEG C after Cynanchum otophyllum Schneid particle drying.
(2) the Qingyang ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the Qingyang ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with the ethanol water that concentration is 70 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -20 DEG C, under 30Pa vacuum degree, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample A1 be made.
Embodiment 2
(1) 2.0kg Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 80 mesh, is subsequently added into 3 times of bodies of Qingyang ginseng grains
The ethanol solution of 60 long-pending weight % impregnates 3 hours at 50 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -30 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -8 DEG C after Cynanchum otophyllum Schneid particle drying.
(2) the Qingyang ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the Qingyang ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with the ethanol water that concentration is 60 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -30 DEG C, under 20Pa vacuum degree, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample A2 be made.
Embodiment 3
(1) 2.0kg Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 40 mesh, is subsequently added into 5 times of bodies of Qingyang ginseng grains
The ethanol solution of 40 long-pending weight % impregnates 1 hour at 80 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter cake that will be obtained
It is freeze-dried at -10 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -2 DEG C after Cynanchum otophyllum Schneid particle drying.
(2) the Qingyang ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the Qingyang ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with the ethanol water that concentration is 80 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -10 DEG C, under 10Pa vacuum degree, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample A3 be made.
Embodiment 4
(1) 2.0kg Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 4 times of Qingyang ginseng grains
The ethanol solution of 35 weight % of volume impregnates 3 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -30 DEG C, under 30Pa vacuum degree.It is placed 2 hours at -10 DEG C after Cynanchum otophyllum Schneid particle drying.
(2) the Qingyang ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 25 DEG C, time 30min, and the power of microwave is 15kW, vacuum degree 15Pa.
(3) it is pulverized, is obtained with the Qingyang ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.6 is mixed with weight ratio with the ethanol water that concentration is 75 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -30 DEG C, under 30Pa vacuum degree, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample A4 be made.
Embodiment 5
(1) 2.0kg Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 3 times of Qingyang ginseng grains
The ethanol solution of 30 weight % of volume impregnates 3 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -25 DEG C, under 20Pa vacuum degree.It is placed 1 hour at -3 DEG C after Cynanchum otophyllum Schneid particle drying.
(2) the Qingyang ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 20 DEG C, time 40min, and the power of microwave is 10kW, vacuum degree 10Pa.
(3) it is pulverized, is obtained with the Qingyang ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.7 is mixed with weight ratio with the ethanol water that concentration is 80 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -25 DEG C, under 20Pa vacuum degree, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample A5 be made.
Embodiment 6
(1) 2.0kg Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 100 mesh, is subsequently added into 5 times of Qingyang ginseng grains
The ethanol solution of 55 weight % of volume impregnates 3 hours at 70 DEG C, with the stainless steel wire net filtration of 200 mesh, the filter that will be obtained
Cake is freeze-dried at -40 DEG C, under 10Pa vacuum degree.It is placed 3 hours at -5 DEG C after Cynanchum otophyllum Schneid particle drying.
(2) the Qingyang ginseng grains that step (1) obtains are placed under vacuum condition and carry out microwave treatment, the condition of microwave treatment
Are as follows: temperature is 30 DEG C, time 20min, and the power of microwave is 20kW, vacuum degree 20Pa.
(3) it is pulverized, is obtained with the Qingyang ginseng grains that CW5-100QA broken wall micronizer obtains step (2)
The micropowders for being 5-30 microns to granularity.
It (4) is that 1:0.5 is mixed with weight ratio with the ethanol water that concentration is 75 weight % by the micropowders,
Then extrusion granulator is freeze-dried at -40 DEG C, under 10Pa vacuum degree, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample A6 be made.
Comparative example 1
Cynanchum otophyllum Schneid broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that not implementing ethanol water immersion
Process, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample D1 be made.
Comparative example 2
Cynanchum otophyllum Schneid broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample D2.
Comparative example 3
Cynanchum otophyllum Schneid broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample D3 be made.
Comparative example 4
Cynanchum otophyllum Schneid broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that not implementing ethanol water immersion
Process, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample D4 be made.
Comparative example 5
Cynanchum otophyllum Schneid broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample D5.
Comparative example 6
Cynanchum otophyllum Schneid broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that after freeze without cold
Freeze storage, but directly carry out microwave treatment, so that Cynanchum otophyllum Schneid broken wall medicine materical crude slice sample D6 be made.
Test case
The non-broken cells limit of Cynanchum otophyllum Schneid broken wall medicine materical crude slice is tested with the following method: taking Cynanchum otophyllum Schneid broken wall medicine materical crude slice
0.1g adds chloraldurate aqueous solution (volume ratio of chloraldurate test solution and water is 1:1) 10ml to be placed on glass slide, and load is set
In microscopically observation, under 10 × 10 times of visuals field, greater than 100 microns and the powder number of complete cell is 0-5.Test
As a result as shown in table 1 below.
Table 1
Can be seen that by the result of table 1 can be made the higher Qingyang of broken wall ratio using method of the present invention
Join broken wall medicine materical crude slice.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (7)
1. a kind of for treating the preparation method of the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis, which is characterized in that including with
Lower step:
(1) dry Cynanchum otophyllum Schneid medicinal material is taken, precomminution to granularity is the particle of 10-100 mesh；
(2) gained particulate matter is immersed in the ethanol water of 30-60 weight %, is filtered, obtained filter cake is freeze-dried,
Then -10 DEG C~0 DEG C at a temperature of place 1-3 hours；
(3) gained Qingyang ginseng grains are placed under vacuum condition and carry out microwave treatment, then pulverized, obtain 40 microns
Micropowders below；
(4) micropowders are mixed with the ethanol water of 60-80 weight %, is then pelletized and is dried.
2. the time is the method according to claim 1, wherein it is 50-80 DEG C that the condition impregnated, which includes: temperature,
1-3 hours.
3. the method according to claim 1, wherein it is -10 DEG C~-50 that the condition of freeze-drying, which includes: temperature,
DEG C, vacuum degree 5-50Pa.
4. the method according to claim 1, wherein the condition of microwave treatment include: temperature be 10-40 DEG C, when
Between be 10-60min, the power of microwave is 5-20kW, vacuum degree 5-50Pa.
5. the method according to claim 1, wherein in step (4), the micropowders and the ethanol water
The mixing mass ratio of solution is 1:0.3-1.
6. the method according to claim 1, wherein the drying is freeze-drying in step (4).
7. the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of the preparation of the method as described in any one of claim 1-6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811573456.1A CN109528794A (en) | 2018-12-21 | 2018-12-21 | For treat the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis preparation method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811573456.1A CN109528794A (en) | 2018-12-21 | 2018-12-21 | For treat the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis preparation method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom |
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| CN109528794A true CN109528794A (en) | 2019-03-29 |
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| CN201811573456.1A Withdrawn CN109528794A (en) | 2018-12-21 | 2018-12-21 | For treat the Cynanchum otophyllum Schneid broken wall medicine materical crude slice of epilepsy and chronic hepatitis preparation method and Cynanchum otophyllum Schneid broken wall medicine materical crude slice prepared therefrom |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
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2018
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
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Application publication date: 20190329 |