CN110123907A - A kind of flavour amino acid granule and preparation method thereof - Google Patents
A kind of flavour amino acid granule and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to Chinese patent drug production field, a kind of flavour amino acid granule and preparation method thereof is provided, for providing a kind of Chinese medicinal granule convenient for brewing.The preparation method of a kind of flavour amino acid granule provided by the invention, comprising: flavour amino acid is removed into impurity, is cleaned, dissection obtains flavour amino acid medicine materical crude slice；Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 1 ~ 3 time, every time plus 5 ~ 20 times of amount water of water, heating decoct 0.25 ~ 2h, combined extract；Extracting solution filtering, the clear cream that it is 1.01~1.20 at relative density that filtrate is concentrated under reduced pressure under the conditions of 30~85 DEG C；The dissolution of the first auxiliary material is added in qinghuo reagent, is spray-dried to obtain dry extract；The second auxiliary material is added in dry extract, dry granulation obtains flavour amino acid granule.Determination of Quercitrin can sustainedly and stably reach higher level in flavour amino acid granule, it is ensured that the active constituent rate of transform and flavour amino acid standard decoction reach the product quality for unanimously improving flavour amino acid granule in flavour amino acid granule.
Description
Technical field
The present invention relates to Chinese patent drug production fields, and in particular to a kind of flavour amino acid granule and preparation method thereof.
Background technique
Cordate houttuynia is saururaceae plant houttuynia cordataHouttuynia cordataThunb. on fresh herb or dry ground
Part.Fresh goods whole year can tap, and the luxuriant flower spike of dry product summer cauline leaf is tapped when more, remove impurity, dry.This product fresh goods and dry
Product can be used as medicine, and fresh goods dosage doubles, and decocting or smash juice clothes, have clearing heat and detoxicating, the effect of the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia, use
In lung carbuncle pyemesis, phlegm heat panting cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
According to research reports, cordate houttuynia fresh goods and dry product compared with a great deal of fresh goods, volatilize in terms of ingredient in fresh goods
Oil content, Determination of Quercitrin are above dry product；In terms of pharmacodynamics, fresh goods is more stronger than dry product anti-inflammatory effect, and clinical efficacy is more aobvious
It writes, has more clinical value, but fresh goods is there are purchasing of raw materials hardly possible, dosage is big, is not easy the problems such as storage and preservation technology are difficult,
It is limited clinically to be widely applied.Therefore, the exploitation of reinforcement fresh medicine preparation technology is needed, it is aobvious to produce effect of fine quality
Chinese medicine fresh medicine preparation, keep Chinese medicine using fresh herb characteristic Chinese Medicine Industry.
Chinese medicinal granule is to be mentioned, be concentrated through water by single medicinal material medicine materical crude slice, dried, pelletized, in tcm clinical practice formula
Afterwards, it takes after mixing it with water use for patient.The quality level of Chinese medicinal granule is with paste-forming rate, finger-print or characteristic spectrum, main work
Property the ingredient rate of transform (or content) three norms and standard decoction (being prepared with the preparation method of traditional Chinese medicine decoction) consistency
It is evaluated.
In conclusion fresh medicine is developed at Chinese medicinal granule, for clinician using modern industrialization equipment and technology
Evolution application, solution fresh medicine buying is difficult, dosage is big, is not easy the problems such as storage and preservation technology are difficult.Currently, there is not yet using Chinese medicine
Multi-function extractor technology prepares the report of flavour amino acid granule.
Summary of the invention
Present invention solves the technical problem that providing a kind of flavour amino acid formula to provide a kind of Chinese medicinal granule convenient for brewing
Particle.
In order to solve the above technical problem, the present invention provides technical solution are as follows:
A kind of flavour amino acid granule, comprising:
Flavour amino acid is removed into impurity, is cleaned, dissection obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 1 ~ 3 time, adds 5 ~ 20 times of amount water of water every time, adds
Heat decocts 0.25 ~ 2h, combined extract；
Extracting solution filtering, the clear cream that it is 1.01~1.20 at relative density that filtrate is concentrated under reduced pressure under the conditions of 30 ~ 85 DEG C；
The dissolution of the first auxiliary material is added in qinghuo reagent, is spray-dried to obtain dry extract；
The second auxiliary material is added in dry extract, dry granulation obtains flavour amino acid granule.
One of effective component quercitin is heat-sensitive ingredients in cordate houttuynia, and ingredient occurs in material wet granulation drying course
Degradation, is preferably suitable for dry granulation, and to improve material viscosity, mobility meets granule and dissolve to adapt to dry granulation
Property require, addition relevant auxiliary materials in clear cream ingredient, and take a step forward in dry granulation and proper auxiliary materials are added adjust its flowing
Property, compressibility.
It extracted, be concentrated under reduced pressure using Multifunctional Chinese medicine extractor, instantaneous spray drying and dry granulation modern industrialization are set
Standby and technology, and various process parameters are studied, to keep flavour amino acid granule Determination of Quercitrin continual and steady
Ground reaches higher level, it is ensured that the active constituent rate of transform and flavour amino acid standard decoction reach one in flavour amino acid granule
It causes, improves the product quality of flavour amino acid granule.Meanwhile granule is made in fresh medicine, it is new for clinical prescription allotment
Increase flavour amino acid granule kind, produces the aobvious Chinese medicine fresh medicine preparation of effect of fine quality, keep the characteristic traditional Chinese medicine of Chinese medicine using fresh herb
Industry has great clinical value and social benefit.
Preferably, described decoct is extracted to be static.
Preferably, described decoct is Dynamic Extraction, and the Dynamic Extraction is to be stirred in decoction process.Dynamic Extraction
Decoction process can be made more abundant, be more advantageous to the dissolution of ingredient.
Preferably, first auxiliary material is one or more of maltodextrin, dextrin, starch, lactose or beta-cyclodextrin.
Mobility, the compressibility of the adjustable clear cream of first auxiliary material.
Preferably, first auxiliary material is maltodextrin.
Preferably, the technological parameter of the spray drying are as follows: 160 DEG C~195 DEG C of inlet air temperature, 80 DEG C of leaving air temp of control
~95 DEG C.
Preferably, second auxiliary material is maltodextrin, dextrin, starch, lactose, beta-cyclodextrin, silica or tristearin
One or more of sour magnesium.
Preferably, second auxiliary material is maltodextrin.
Preferably, second auxiliary material is the mixture of maltodextrin and silica.
A kind of flavour amino acid granule, the flavour amino acid granule prepared according to above-mentioned preparation method.
Compared with prior art, the device have the advantages that are as follows: using Multifunctional Chinese medicine extractor extract, depressurize it is dense
Contracting, instantaneous spray drying and dry granulation modern industrialization equipment and technology, and various process parameters are studied, to make
Flavour amino acid granule Determination of Quercitrin can sustainedly and stably reach higher level, it is ensured that living in flavour amino acid granule
Property the ingredient rate of transform and flavour amino acid standard decoction reach the product quality for unanimously improving flavour amino acid granule.
Meanwhile granule is made in fresh medicine, flavour amino acid granule kind is newly increased for clinical prescription allotment, is produced
The aobvious Chinese medicine fresh medicine preparation of effect of fine quality, keeps the characteristic Chinese Medicine Industry of Chinese medicine using fresh herb, with great clinical value and
Social benefit.
Specific embodiment
The present invention is explained further below in conjunction with specific embodiment, but embodiment does not do any type of limit to the present invention
It is fixed.
Embodiment 1
A kind of flavour amino acid granule, comprising:
Flavour amino acid is removed into impurity, is cleaned, is cut into the section of 0.1 ~ 3cm, obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 1 time, every time plus 20 times of amount water of water, heating are decocted
Boil 1h, combined extract；
Extracting solution filtering, the clear cream that it is 1.06 at relative density that filtrate is concentrated under reduced pressure under the conditions of 60 DEG C；
Maltodextrin dissolution is added in qinghuo reagent, is spray-dried to obtain dry extract；
Maltodextrin is added in dry extract, dry granulation obtains flavour amino acid granule.Described decoct is Dynamic Extraction, described
Dynamic Extraction is to be stirred in decoction process.The technological parameter of the spray drying are as follows: 170 DEG C of inlet air temperature of control~
180 DEG C, 80 DEG C~90 DEG C of leaving air temp.
One of effective component quercitin is heat-sensitive ingredients in cordate houttuynia, and ingredient occurs in material wet granulation drying course
Degradation, is preferably suitable for dry granulation, and to improve material viscosity, mobility meets granule and dissolve to adapt to dry granulation
Property require, addition relevant auxiliary materials in clear cream ingredient, and take a step forward in dry granulation and proper auxiliary materials are added adjust its flowing
Property, compressibility.
It extracted, be concentrated under reduced pressure using Multifunctional Chinese medicine extractor, instantaneous spray drying and dry granulation modern industrialization are set
Standby and technology, and various process parameters are studied, to keep flavour amino acid granule Determination of Quercitrin continual and steady
Ground reaches higher level, it is ensured that the active constituent rate of transform and flavour amino acid standard decoction reach one in flavour amino acid granule
It causes, improves the product quality of flavour amino acid granule.Meanwhile granule is made in fresh medicine, it is new for clinical prescription allotment
Increase flavour amino acid granule kind, produces the aobvious Chinese medicine fresh medicine preparation of effect of fine quality, keep the characteristic traditional Chinese medicine of Chinese medicine using fresh herb
Industry has great clinical value and social benefit.Dynamic Extraction can make decoction process more abundant, be more advantageous to
The dissolution of ingredient.Mobility, the compressibility of the adjustable clear cream of first auxiliary material.
Embodiment 2
A kind of flavour amino acid granule, comprising:
Flavour amino acid is removed into impurity, is cleaned, is cut into the section of 0.1 ~ 3cm, obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 2 times, every time plus 12 times of amount water of water, heating are decocted
Boil 0.5h, combined extract；
Extracting solution filtering, the clear cream that it is 1.06 at relative density that filtrate is concentrated under reduced pressure under the conditions of 60 DEG C；
Qinghuo reagent is added maltodextrin and dissolves and stir evenly, and is spray-dried to obtain dry extract；
Maltodextrin and silica is added in dry extract, is uniformly mixed, dry granulation obtains flavour amino acid granule.It is described
Decocting is Dynamic Extraction, and the Dynamic Extraction is to be stirred in decoction process.The technological parameter of the spray drying are as follows: control
170 DEG C~180 DEG C of inlet air temperature processed, 80 DEG C~90 DEG C of leaving air temp.
Embodiment 3
A kind of flavour amino acid granule, comprising:
Flavour amino acid is removed into impurity, is cleaned, is cut into the section of 0.1 ~ 3cm, obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 3 times, every time plus 5 times of amount water of water, heating decoct
0.25h, combined extract；
Extracting solution filtering, the clear cream that it is 1.01 at relative density that filtrate is concentrated under reduced pressure under the conditions of 50 DEG C；
The dissolution of the first auxiliary material is added in qinghuo reagent, is spray-dried to obtain dry extract；
The second auxiliary material is added in dry extract, dry granulation obtains flavour amino acid granule.Described decoct is Dynamic Extraction, described
Dynamic Extraction is to be stirred in decoction process.First auxiliary material is maltodextrin, dextrin, starch, lactose or β-ring paste
One or more of essence.The technological parameter of the spray drying are as follows: 170 DEG C~180 DEG C of inlet air temperature of control, leaving air temp 80
DEG C~90 DEG C.Second auxiliary material is in maltodextrin, dextrin, starch, lactose, beta-cyclodextrin, silica or magnesium stearate
One or more.
Embodiment 4
A kind of flavour amino acid granule, comprising:
Flavour amino acid is removed into impurity, is cleaned, dissection obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 1 time, every time plus 20 times of amount water of water, heating are decocted
Boil 2h, combined extract；
Extracting solution filtering, the clear cream that it is 1.20 at relative density that filtrate is concentrated under reduced pressure under the conditions of 80 DEG C；
The dissolution of the first auxiliary material is added in qinghuo reagent, is spray-dried to obtain dry extract；
The second auxiliary material is added in dry extract, dry granulation obtains flavour amino acid granule.Described decoct is Dynamic Extraction, described
Dynamic Extraction is to be stirred in decoction process.First auxiliary material is maltodextrin, dextrin, starch, lactose or β-ring paste
One or more of essence.The technological parameter of the spray drying are as follows: 170 DEG C~180 DEG C of inlet air temperature of control, leaving air temp 80
DEG C~90 DEG C.Second auxiliary material is in maltodextrin, dextrin, starch, lactose, beta-cyclodextrin, silica or magnesium stearate
One or more.
Comparative example 1
A kind of preparation method of flavour amino acid standard decoction, includes the following steps:
Flavour amino acid is removed into impurity, is cleaned, dissection obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into traditional ceramics cooking pot for herbs, is added water to cook 2 times, adds 12 times of amount water for the first time, boils by intense fire
Afterwards, change the slightly boiled decoction of mild fire holding 20 minutes, second plus 10 times of amount water, after boiling by intense fire, change mild fire and keep slightly boiled decoction 15
Minute, combined extract；
Extracting solution filtering, filtrate are concentrated under reduced pressure into the clear cream of 2 times of amounts of inventory at 60 DEG C；
Qinghuo reagent is freeze-dried to get flavour amino acid standard decoction (freeze-dried powder).
Comparative example 2
Comparative example 2 with embodiment 2 the difference is that, carried out in flavour amino acid medicine materical crude slice investment traditional ceramics cooking pot for herbs pan-fried
It boils, described decoct is extracted to be static.
Comparative example 3
Comparative example 3 with embodiment 2 the difference is that, the technological parameter of the spray drying are as follows: control inlet air temperature 195 ~ 200
DEG C, 95 ~ 100 DEG C of leaving air temp.
Comparative example 4
Comparative example 4 with embodiment 1 the difference is that, it is described by flavour amino acid medicine materical crude slice put into Multifunctional Chinese medicine extractor in, add
Water decocts 5 times, and every time plus 4 times of amount water of water, heating decoct 3h, combined extract.
Comparative example 5
Comparative example 5 with embodiment 1 the difference is that, it is described by flavour amino acid medicine materical crude slice put into Multifunctional Chinese medicine extractor in, add
Water decocts 5 times, and every time plus 21 times of amount water of water, heating decoct 3h, combined extract.
Comparative example 6
A kind of flavour amino acid granule, comprising:
Flavour amino acid is removed into impurity, cleans, obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 1 time, every time plus 12 times of amount water of water, heating are decocted
Boil 2h, combined extract；
Extracting solution filtering, the clear cream that it is 1.06 at relative density that filtrate is concentrated under reduced pressure under the conditions of 60 DEG C；
Qinghuo reagent is added maltodextrin and dissolves and stir evenly, and is spray-dried to obtain dry extract；
Maltodextrin and silica is added in dry extract, is uniformly mixed, dry granulation obtains flavour amino acid granule.It is described
Decocting is Dynamic Extraction, and the Dynamic Extraction is to be stirred in decoction process.The technological parameter of the spray drying are as follows: control
170 DEG C~180 DEG C of inlet air temperature processed, 80 DEG C~90 DEG C of leaving air temp.
Experimental example
The flavour amino acid granule that embodiment and comparative example is prepared measures the content of quercitin, calculates paste-forming rate, turns
Shifting rate situation, the results are shown in Table 1.
1 Chinese medicinal granule performance indicator of table
Whether granule can replace corresponding standard decoction product, and main judgment basis is in the granule of homogenous quantities
Effective component and standard decoction in active constituent content it is whether identical.Freeze-dried powder is not easy to store, moisture-sensitive, therefore cannot be big
Area is promoted.
From embodiment 1,2 and comparative example 1 it can be seen that the application Multifunctional Chinese medicine extractor is extracted, is concentrated under reduced pressure, wink
When spray drying and dry granulation modern industrialization equipment and technology, it can be ensured that active constituent shifts in flavour amino acid granule
Rate and flavour amino acid standard decoction reach unanimously, and the process stabilizing is feasible, can newly increase flavour amino acid for clinical prescription allotment and match
Square particle species.
Embodiment 3 and 4 shows in the process parameters range of the preparation method of the application, available same flavour amino acid
The consistent flavour amino acid granule of the active constituent of standard decoction.
Multifunctional Chinese medicine extractor is not used in comparative example 2, but uses traditional ceramic medicine herbs decocting pot and extracts, into
Prepared by active constituent in particle have biggish difference compared with embodiment or comparative example 1.
The temperature being spray-dried in comparative example 3 is excessively high, and the content of quercitin is caused to decline to a great extent.
The extracting mode of flavour amino acid in comparative example 4 and 5 is the same as the difference recorded in embodiment, amount of water and decocting time
It is different, cause the amount of quercitin in granule to be significantly less than embodiment 1 ~ 4.Show to propose method or right using different water
The water of flavour amino acid proposes the adjustment that parameter carries out over range, will lead to the decline of granule quality.
The non-dissection of cordate houttuynia medicine materical crude slice in comparative example 6, is directly decocted, and the decoction used time is longer, while effective component
Content is relatively low, shows that cordate houttuynia dissection is to improve the important means of active principle content.
Above-listed detailed description is illustrating for possible embodiments of the present invention, and above embodiments are not to limit this
The scope of the patents of invention, all equivalence enforcements or change without departing from carried out by the present invention, is intended to be limited solely by the scope of the patents of this case.
Claims (10)
1. a kind of preparation method of flavour amino acid granule characterized by comprising
Flavour amino acid is removed into impurity, is cleaned, dissection obtains flavour amino acid medicine materical crude slice；
Flavour amino acid medicine materical crude slice is put into Multifunctional Chinese medicine extractor, is added water to cook 1 ~ 3 time, adds 5 ~ 20 times of amount water of water every time, adds
Heat decocts 0.25 ~ 2h, combined extract；
Extracting solution filtering, the clear cream that it is 1.01~1.20 at relative density that filtrate is concentrated under reduced pressure under the conditions of 30 ~ 85 DEG C；
The dissolution of the first auxiliary material is added in qinghuo reagent, is spray-dried to obtain dry extract；
The second auxiliary material is added in dry extract, dry granulation obtains flavour amino acid granule.
2. a kind of preparation method of flavour amino acid granule according to claim 1, which is characterized in that the decoction is
Static state is extracted.
3. a kind of preparation method of flavour amino acid granule according to claim 1, which is characterized in that the decoction is
Dynamic Extraction, the Dynamic Extraction are to be stirred in decoction process.
4. a kind of preparation method of flavour amino acid granule according to claim 1, which is characterized in that described first is auxiliary
Material is one or more of maltodextrin, dextrin, starch, lactose or beta-cyclodextrin.
5. a kind of preparation method of flavour amino acid granule according to claim 1, which is characterized in that described first is auxiliary
Material is maltodextrin.
6. a kind of preparation method of flavour amino acid granule according to claim 1, which is characterized in that described spraying dry
Dry technological parameter are as follows: 160 DEG C~195 DEG C of inlet air temperature, 80 DEG C~95 DEG C of leaving air temp of control.
7. a kind of preparation method of flavour amino acid granule according to claim 1, which is characterized in that described second is auxiliary
Material is one or more of maltodextrin, dextrin, starch, lactose, beta-cyclodextrin, silica or magnesium stearate.
8. a kind of preparation method of flavour amino acid granule according to claim 7, which is characterized in that described second is auxiliary
Material is maltodextrin.
9. a kind of preparation method of flavour amino acid granule according to claim 7, which is characterized in that described second is auxiliary
Material is the mixture of maltodextrin and silica.
10. a kind of flavour amino acid granule, which is characterized in that described in any item preparation method systems according to claim 1 ~ 9
Standby flavour amino acid granule.
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| CN114113348A (en) * | 2020-08-26 | 2022-03-01 | 国药集团同济堂（贵州）制药有限公司 | Preparation method, characteristic spectrum and content determination method of rose standard decoction |
| CN114113348B (en) * | 2020-08-26 | 2023-10-17 | 国药集团同济堂（贵州）制药有限公司 | Preparation method of standard rose decoction, characteristic spectrum and content determination method |
| CN113368061A (en) * | 2021-05-28 | 2021-09-10 | 河北红日药都药业有限公司 | Method for improving extract of sugar-containing formula particles |
| CN113616600A (en) * | 2021-08-05 | 2021-11-09 | 广东汇群中药饮片股份有限公司 | Traditional Chinese medicine compound granule for treating spleen-lung qi deficiency and preparation method thereof |
| CN113616600B (en) * | 2021-08-05 | 2023-07-14 | 广东汇群中药饮片股份有限公司 | Chinese medicinal compound granule for treating spleen and lung qi deficiency and preparation method thereof |
| CN114748431A (en) * | 2022-05-06 | 2022-07-15 | 广东一方制药有限公司 | Preparation method of traditional Chinese medicine granules |
| CN114848600A (en) * | 2022-06-14 | 2022-08-05 | 广东一方制药有限公司 | Fresh motherwort traditional Chinese medicine formula particle and preparation method thereof |
| CN114848600B (en) * | 2022-06-14 | 2023-08-29 | 广东一方制药有限公司 | Fresh motherwort traditional Chinese medicine formula granule and preparation method thereof |
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Application publication date: 20190816 |