CN101926899B - Health-care medicament for hyperlipemia and preparation method thereof - Google Patents
Health-care medicament for hyperlipemia and preparation method thereof Download PDFInfo
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- CN101926899B CN101926899B CN2010102737283A CN201010273728A CN101926899B CN 101926899 B CN101926899 B CN 101926899B CN 2010102737283 A CN2010102737283 A CN 2010102737283A CN 201010273728 A CN201010273728 A CN 201010273728A CN 101926899 B CN101926899 B CN 101926899B
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Abstract
The invention relates to a health-care medicament for hyperlipemia and a preparation method thereof. The hyperlipemia is a common and frequently-occurring metabolic disease. The conventional medicaments for treating the hyperlipemia are mostly single medicinal components; and the medicinal components have wide varieties, and have side effect after taken for long. The invention provides the health-care medicament for the hyperlipemia and the preparation method thereof. The medicament consists of the following raw materials in part by weight: 280 to 320 parts of hawthorn fruit, 280 to 320 parts of tuber fleeceflower root, 180 to 220 parts of oriental waterplantain rhizome, 80 to 120 parts of earthworm and 80 to 120 parts of lotus leaf. The preparation method comprises the following steps of: preparing extracts, adding starch, granulating the mixture by a wet method and preparing the mixture into capsules. The prescription of the medicament is rational and scientific; the medicament is prepared by refining by a scientific method; and the compositional plants and animals of the medicament are mostly the components functioning as both food and the medicament, so the medicament does not have any toxic or side effect on human bodies, has remarkable effect and is easy to use for long.
Description
Technical field
The present invention relates to a kind of health medicine, specifically is a kind of health medicine that is used for hyperlipidemia and preparation method thereof.
Background technology
Improving constantly owing to the material life level in the modern society, the change of dietary structure, people's diet is careless, preference for fat and sweet food, cause figure's obesity in the middle-aged and elderly people, blood fat higher person increase suddenly, and modern medicine study is thought: hyperlipidemia is a kind of common and multiple metabolic disease, mainly shows as the normal level that is higher than of one or more compositions in the blood plasma lipide.Blood fat is higher to be the principal element that causes the atherosclerotic cardiovascular and cerebrovascular disease.The tradition traditional Chinese medical science thinks that the generation of hyperlipidemia is relevant with composite factors such as age, diet, body constitution and heredity, though it is sick intricate, its basic pathology becomes deficiency in origin and excess in superficiality, promptly kidney,liver,spleen deficient this, the expectorant stasis of blood is for marking.The rule of treatment should be blood circulation promoting and blood stasis dispelling, resolving turbidity and eliminating dampness, and nourishing the liver and kidney, dredging the meridian is main.In the medicine of present treatment hyperlipidemia, be single medicinal ingredient all mostly, ingredient is of a great variety, and is long-term edible, has side effect.
Summary of the invention
The object of the present invention is to provide a kind of health medicine that is used for hyperlipidemia and preparation method thereof, its reasonable recipe science processes through scientific method is refining, and forms animals and plants and mostly be the food and medicament dual-purpose composition, without any side effects to the human body thing, and effect obviously is easy to life-time service.
For achieving the above object, the technical solution used in the present invention is: a kind of health medicine that is used for hyperlipidemia is characterized in that: the raw material by following weight portion is formed,
Fructus Crataegi 280-320 part, Radix Polygoni Multiflori 280-320 part, Rhizoma Alismatis 180-220 part, Pheretima 80-120 part, Folium Nelumbinis 80-120 part.
The above-mentioned health medicine that is used for hyperlipidemia is made up of the raw material of following weight portion,
300 parts of Fructus Crataegis, 300 parts of Radix Polygoni Multiflori, 200 parts of Rhizoma Alismatis, 100 parts of Pheretimas, 100 parts on Folium Nelumbinis.
The preparation method of above-mentioned health medicine is characterized in that, comprises the steps:
One, preparation extract
Get above-mentioned Six-element bulk drugs and pulverize, make fine powder, the fine powder particle diameter is 5-10 μ m; Adopt decocting to boil three times the gained fine powder, each two hours, filter; Filtrate is condensed into medical material: medicinal liquid is the ratio of 2:1; Adding volume fraction in the medicinal liquid of gained is 95% ethanol, and making concentration of alcohol is 60%, precipitates after 2 days to filter once more; Filtering filtrate concentrating made dry extract;
Two, preparation capsule
Extract dry extract at first step adds the starch wet granulation, and aeration-drying below 80 ℃ becomes capsule with the dried particles fill.
The present invention has following advantage and effect with respect to prior art:
1, according to the combination of modern medical theory and Chinese medicine theory, after the higher pathogeny of analysis-by-synthesis human body blood fat, at body blood fat height, select animals and plants Chinese medicine for use, scientific composition, refining forming, and animals and plants mostly are the food and medicament dual-purpose composition, treatment and health care combine, and human body is had no side effect, and are suitable for long-term edible;
2, adopt superfine communication technique, the cell wall rupture of the most cells of medical material, effective ingredient need directly not contact with medicine-feeding part through the cell wall barrier in the cell, medicated powder very easily is adsorbed on the small bowel, absorbed by small bowel, the stripping and the utilization rate of effective ingredient can effectively be provided, strengthen the quality of preparation.
The specific embodiment
Motherland's medical science thinks, it is the turbid resistance network of expectorant, qi depression to blood stasis that hyperlipidemia forms pathogenesis, and the cavalryman is because of being more common in food delicious food savoury, dysfunction of the spleen in transportation, wet poly-for expectorant, expectorant is turbid does not change, or the liver failing to maintain the normal flow of QI, or insufficiency of stomach is warm unable, gives birth in expectorant is turbid, finally in arteries and veins, qi depression to blood stasis forms.The present invention is made up of Fructus Crataegi, Radix Polygoni Multiflori, Rhizoma Alismatis, Pheretima, Folium Nelumbinis Six-element Chinese medicine, and wherein, the Pheretima nature and flavor are salty-cold, return liver spleen urinary bladder channel, have clearing heat for calming endogenous wind, the collateral dredging diuresis of relievining asthma, be monarch drug, and Pheretima contains abundant earthworm kinases, have good thrombolytic effect; Hawthorn digesting eliminate indigestion blood circulation promoting and blood stasis dispelling is ministerial drug, cooperates monarch drug to strengthen the function of blood circulation promoting and blood stasis dispelling, Radix Polygoni Multiflori is returned liver heart kidney channel, have liver and kidney tonifying, the effect of nourishing blood to expel wind, loosening bowel to relieve constipation is with the public effect of Rhizoma Alismatis clearing away heat and promoting diuresis eliminating dampness by diuresis, to avoid wet gathering is that expectorant is turbid, the soldier is in blood vessels, and it is an adjuvant drug, is amusing with the Folium Nelumbinis cooling blood for hemostasis the lucid yang sending up that light weight is up, be apt to reach the heart and brain position, be messenger drug.Therefore, monarch of the present invention, minister, help, make essence to delay, compatibility Radix Polygoni Multiflori, Rhizoma Alismatis are that turbid damp is discharged from defecation among Pheretima, Fructus Crataegi blood circulation promoting and blood stasis dispelling, a surname's numbness collateral dredging, be difficult to hinder in arteries and veins, join Folium Nelumbinis with Fructus Crataegi again, spleen invigorating is amusing in the time of blood circulation promoting and blood stasis dispelling, is the strong fortune of spleen, can not gather the wet expectorant that is, its prescription compatibility flavour of a drug are less, treatment must aim at the pathogenesis of disease, treating both the principal and secondary aspects of a disease.
Six-element herbal nature composition of the present invention is as follows:
Radix Polygoni Multiflori contains anthraquinone component, be mainly emodin, chrysophanol etc., contain abundant starch, crude fat, lecithin etc. in addition, the modern pharmacology experiment shows: Radix Polygoni Multiflori is to high fat patient's in old age triglyceride, cholesterol and high-density protein cholesterol all have clear improvement, and have the cholesterol of minimizing synthetic or conversion of acceleration cholesterol and excretory effect.
Fructus Crataegi always mainly contains the Fructus Crataegi acids, flavonoid, glycoside and lactone composition, pharmacological evaluation shows, Cavia porcellus hepatocyte microsome and the synthetic speed limit of mucous membrane of small intestine cholesterol after the Fructus Crataegi water decoction serve on for 3 weeks, enzyme hydroxyl first glutaryl CoA reductase active component descends 70% and 67% respectively, in addition Fructus Crataegi total flavones can diastole coronary vasodilator, 15% and 30% hawthorn extract has tangible effect for reducing fat to the young rat of breast.
Mainly contain pentacyclic triterpenoid and part unsaturated fatty acids such as Alisol A, B in the Rhizoma Alismatis, pharmacological evaluation shows: the Rhizoma Alismatis water decoction has therapeutical effect to the fatty liver that the low proteic diet of rat causes, can alleviate the hyperlipidemia that the oral Oleum Gossypii semen of rat causes, and can slightly reduce the atherosclerotic cholesterolemia of rabbit experiment, relax the development of pathological changes, the absorption of its effect for reducing fat and the exogenous cholesterol of its interference is relevant with the metabolism of endogenous cholesterol.
Folium Nelumbinis is food and medicament dual-purpose plant commonly used, modern study finds that it contains abundant lotus alkali, organic acids such as multiple biological alkali such as lotus alkali and quercetin, pharmacological evaluation shows that the Folium Nelumbinis water decoction has tangible decline effect to triglyceride, cholesterol, it can impel unnecessary lipid drainage in the human body, the draw up absorption of exogenous lipid promotes the metabolism of cholesterol, thereby reaches the effect of blood fat reducing.
Pheretima is a kind of animal of food and medicament dual-purpose commonly used, wherein contain essential several amino acids, protein and unsaturated fatty acid in the human body, and contain active ingredient Pheretima enzyme of blood circulation promoting and blood stasis dispelling etc., it has the effect that increases human bloodstream amount, microcirculation improvement and share with Radix Polygoni Multiflori and can strengthen getting rid of lipide component from human body blood the effect of reduction whole blood apparent viscosity.
Embodiment 1
A kind of health medicine that is used for hyperlipidemia has the preparation of following method: at first get Fructus Crataegi 280g, Radix Polygoni Multiflori 320 g, Rhizoma Alismatis 180 g, Pheretima 120 g, Folium Nelumbinis 80 g pulverize, and make the fine powder that particle diameter is 5-10 μ m; Adopt decocting to boil three times the gained fine powder, each two hours, filter; Filtrate is condensed into medical material: medicinal liquid is the ratio of 2:1; Add 95% ethanol in the medicinal liquid of gained, making concentration of alcohol is 60%, precipitates after 2 days to filter once more; Filtering filtrate concentrating made dry extract; Dry extract is added the starch wet granulation, and aeration-drying below 80 ℃ becomes capsule with the dried particles fill.
Embodiment 2
A kind of health medicine that is used for hyperlipidemia has the preparation of following method: get Fructus Crataegi 302g, Radix Polygoni Multiflori 280 g, Rhizoma Alismatis 220 g, Pheretima 80 g, Folium Nelumbinis 120 g pulverize, and make the fine powder that particle diameter is 5-10 μ m; Adopt decocting to boil three times the gained fine powder, each two hours, filter; Filtrate is condensed into medical material: medicinal liquid is the ratio of 2:1; Adding volume fraction and be 95% ethanol in the medicinal liquid of gained, to make concentration of alcohol be 60%, precipitates after 2 days and filter once more; Filtering filtrate concentrating made dry extract; Dry extract is added the starch wet granulation, and aeration-drying below 80 ℃ becomes capsule with the dried particles fill.
Embodiment 3
A kind of health medicine that is used for hyperlipidemia has the preparation of following method: get Fructus Crataegi 300g, Radix Polygoni Multiflori 300 g, Rhizoma Alismatis 200 g, Pheretima 100 g, Folium Nelumbinis 100 g pulverize, and make the fine powder that particle diameter is 5-10 μ m; Adopt decocting to boil three times the gained fine powder, each two hours, filter; Filtrate is condensed into medical material: medicinal liquid is the ratio of 2:1; Adding volume fraction in the medicinal liquid of gained is 95% ethanol, and making concentration of alcohol is 60%, precipitates after 2 days to filter once more; Filtering filtrate concentrating made dry extract; Dry extract is added the starch wet granulation, and aeration-drying below 80 ℃ becomes capsule with the dried particles fill.
Best in the foregoing description with embodiment 3 effects.
Claims (3)
1. health medicine that is used for hyperlipidemia, it is characterized in that: the raw material by following weight portion is formed,
Fructus Crataegi 280-320 part Radix Polygoni Multiflori 280-320 part Rhizoma Alismatis 180-220 part
Pheretima 80-120 part Folium Nelumbinis 80-120 part.
2. a kind of health medicine that is used for hyperlipidemia according to claim 1, it is characterized in that: the raw material by following weight portion is formed,
100 parts on 100 parts of Folium Nelumbinis of 200 parts of Pheretimas of 300 portions of Rhizoma Alismatis of 300 parts of Radix Polygoni Multiflori of Fructus Crataegi.
3. the preparation method of claim 1 or 2 described health medicines is characterized in that, comprises the steps:
One, preparation extract
Get the Six-element crude drug of described weight portion and pulverize, make fine powder, the fine powder particle diameter is 5-10 μ m; Adopt decocting to boil three times the gained fine powder, each two hours, filter; Filtrate is condensed into medical material: medicinal liquid is the ratio of 2:1; Adding volume fraction in the medicinal liquid of gained is 95% ethanol, and making concentration of alcohol is 60%, precipitates after 2 days to filter once more; Filtering filtrate concentrating made dry extract;
Two, preparation capsule
Extract dry extract at first step adds the starch wet granulation, and aeration-drying below 80 ℃ becomes capsule with the dried particles fill.
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| CN104857424A (en) * | 2015-04-27 | 2015-08-26 | 张斌 | Medicine for treating thick blood lipid and preparation method thereof |
| CN106474219A (en) * | 2016-11-11 | 2017-03-08 | 天津蚓福生物科技开发有限公司 | Blood fat reducing pressed candy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147952A (en) * | 1996-09-09 | 1997-04-23 | 王全江 | Tea for preventing and curing coronary heart disease and method for preparing same |
| CN1660207A (en) * | 2004-12-29 | 2005-08-31 | 韦平生 | Preparation of health care for reducing blood fat and cholesterol, and producing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH02215725A (en) * | 1989-02-15 | 1990-08-28 | Eimei:Kk | Anti-hyperlipidemia agent |
| JP2009249362A (en) * | 2008-04-09 | 2009-10-29 | Ｗｅｌｌ Ｓｔｏｎｅ 有限会社 | Method for producing detoxified dried earthworm powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147952A (en) * | 1996-09-09 | 1997-04-23 | 王全江 | Tea for preventing and curing coronary heart disease and method for preparing same |
| CN1660207A (en) * | 2004-12-29 | 2005-08-31 | 韦平生 | Preparation of health care for reducing blood fat and cholesterol, and producing method |
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Effective date of registration: 20170526 Address after: Qin Yue Lu 712000 Xianyang city of Shaanxi Province Qin District No. 9 Patentee after: Shaanxi Jun Dekang Pharmaceutical Co. Ltd. Address before: The road high tech Zone Technology 710065 Shaanxi city of Xi'an province No. 30 B block 701 Cheshire force Patentee before: Xu Yang |