CN106474219A - Blood fat reducing pressed candy - Google Patents
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Abstract
The invention discloses a kind of blood fat reducing pressed candy, it is made up of the raw material of following weight parts：150 250 parts of earthworm protein powder, 250 350 parts of Fructus Crataegi extract, 150 250 parts of Folium Nelumbinis extract, 500 600 parts of honey peach fruit powder, 5 15 parts of peach flavor, 100 150 parts of sugar alcohol, 50 90 parts of Microcrystalline Cellulose, 15 25 parts of hydroxypropyl methyl cellulose, 10 20 parts of magnesium stearate.Blood fat reducing pressed candy of the present invention, with earthworm protein powder, Fructus Crataegi extract and Folium Nelumbinis extract as main composition, with sugar alcohol, Microcrystalline Cellulose, hydroxypropyl methyl cellulose as adjuvant, is eaten for a long time the function with blood fat reducing, resisting fatigue, enhancing immunity.
Description
Technical field
The present invention relates to technical field of health care food is and in particular to a kind of blood fat reducing pressed candy.
Background technology
Pheretima (Latin literary fame：Pheretima) it is one of important Chinese crude drug of China.Earliest Chinese materia medica monograph《The legendary god of farming
Herbal warp》In just have Lumbricuss in 67 kinds of animal drugs recording.Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》It is referred to as with dredge the meridian passage, promoting blood circulation
Blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease,《Compendium of Materia Medica》There is more than 40 kind of pharmacologic action in worm portion.Pheretima is except having
Outside better nutritivity is worth, it also has a lot of health cares, can strengthen the premunition of human body, improves the health level of people.Pheretima
There is many pharmacological actions, be related to each system of human body such as cardiovascular system, blood system, immune system, nervus centraliss
System, respiratory system, digestive system etc..Especially in terms of cardiovascular system and blood system, Pheretima can prevent height well
Blood pressure, myocardial infarction, arrhythmia, apoplexy thromboembolism etc..
Modern pays close attention to Pheretima earliest and arises from Japan after World War II, as the minority species survived in explosion of atomic bomb region
One of, Japanese Scientists just set about being studied, in view of technical conditions at that time, the progress of making a breakthrough property, does not arrive
Nineteen eighty-three, the U.S. former perseverance professor of Japanese Scientists leads its Research Team, has started the tackling key problem of earthworm protein extractive technique.This phase
Between, the Jeffree professor of the U.S., the Cartel professor of Germany, all in succession confirm the sp act that earthworm protein has, Pheretima
Albumen becomes the research focus of world's life sciences circle.2003, after the experience tackling key problem process of 20 years, U.S. former permanent scientific research group
Team in experiments it is found that, simulates " have no progeny and live again " phenomenon to live body Lumbricuss, can stimulate a large amount of secretions of earthworm protein.Taking
After new separating and purifying technology, U.S. former permanent team achieves the extensive extraction of earthworm protein finally, and extracts
The earthworm protein of high purity 99%, earthworm protein enters the extensive transformation stage.
Earthworm protein, with modern biotechnology, using supercritical low-temperature extraction technology, from (compatriot's love victory) Lumbricuss
The high purity protein (regeneration compound enzyme) of middle extraction.
Earthworm protein contains the Multiple components such as collagenase, fibrinolysin, nucleic acid, trace element.Pheretima extract (includes earthworm to swash
Enzyme etc.) to internal blood coagulation system and fibrinolytic system, there is wide influence, both can obviously reduce platelet adhesion reaction rate, extension body
Interior thrombosiss and dissolving thrombus in vivo, can increase cerebral blood flow again, reduce cerebral vascular resistance.Pheretima extract can also improve red
Cytomorphosiss ability, thus improve hemorheological property and microcirculation disturbance.The medical expert of countries in the world by every means, using molten
The means such as bolt, anticoagulant, expansion of blood vessels, blood circulation promoting and blood stasis dispelling, to dredge big blood vessel, but cannot tackle the problem at its root.In August, 1996
16, after the Continuous Observation several months, U.S. former permanent professor found that earthworm protein can be thin in cerebral lesion region regeneration blood capillary, nerve
Born of the same parents.This discovery, has established U.S. former permanent professor in the status of world medical circle, has become the leading of world's cerebrovascular medical research
Personage.In whole experiment, earthworm protein, just as cellular replication agent, makes the blood capillary only deposited and neurocyte constantly multiple
System, forms tissue then, produces normal function of organization.This discovery causes the very big concern of global medical circle immediately：Brain
Interior microvascular lesions and necrosis, are to cause cerebrovascular to be difficult to the basic reason cured, earthworm protein is successfully applied, and makes brain blood
A treatment difficult problem for pipe disease is readily solved.
(1) improve microcirculation comprehensively
The Multiple components such as collagenase, fibrinolysin, Lumbrukinase, nucleic acid, trace element are had, its molecular weight exists in earthworm protein
5000-10000, belongs to short chain small-molecule substance, can smoothly enter blood capillary, the micro- bolt in dissolving blood capillary, allows hardening
Blood capillary recovers elasticity, thus releasing microvascular blocking, torsional deformation situation, directly dissolving forms the main body thing of human thrombus
Matter fibrin, thus playing the direct thrombolytic effect of strength, dissolves fresh and old thrombosis, it is possible to increase human body itself
Anticoagulating activity, can activate the differentiation characteristic of vascular endothelial cell, get through passages through which vital energy circulates, promote blood capillary regeneration, set up collateral circulation, be
The heart and brain tissues of focal zone open up new blood access, repair the cranial nerve cell of necrosis, cure hemiplegia, thus reaching persistently molten
The effect of bolt, the prevention to cardiovascular and cerebrovascular disease, the rehabilitation of apoplexy sequela is significant.Contribute to eliminating and microcirculation simultaneously again
The relevant aging of obstacle and tumor occur, and also improve whole body various physiological-function and health status, enhance immunity.
(2) thrombus
Earthworm protein fibre rich protein resolvase, can activate the fibrinoclase unit in thrombosis, be allowed to be converted into
There is the fibrin in fibrinoclase, and then thrombus, fresh thromboembolism.Fibrinoclase is again
Can direct thrombus, the thromboembolism of old.Thrombus do not affect internal clotting mechanism, do not cause bleeding
Side effect.
(3) vessel softening, stablizes speckle
Fibrinoclase contained by earthworm protein and other active matter mass-energy dissolve fiber in atherosis blood vessel wall
Albumen net, eliminates the pathological products such as cholesterol plaques attached thereto, promotes the synthesis of vascular endothelial cell DNA, promotes
The reparation of vascular damaged, expansion of blood vessels, recover blood vessel elasticity, make unblocked blood flowing, change and prevent dynamic to a certain extent
The natural history of arteries and veins hardening.
(4) reduce blood to glue
Earthworm protein dissolving with thrombosis in human body, the softening of blood vessel, microcirculatory improvement, reduce hyperlipidemia
Degree, makes abnormal hemorheology index recover normal, so that Microcirculation of Nailfold is detected normal by extremely switching to, thus eliminate sending out
The raw unexpected hidden danger of cardiovascular and cerebrovascular vessel.
(5) two-ways regulation blood pressure
Earthworm protein is improved pipe and is enclosed state by recovering blood elasticity, expansion of blood vessels, thrombus, improving microcirculation,
Reduce blood flow Peripheral resistance, reduce blood viscosity and there is stable hypotensive effect.For essential hypertension, blood can be made
Voltage-controlled system is after normally close to normal level；For severe hypertension disease or cardiovascular and cerebrovascular vessel Complicated with Hypertension, other can be strengthened
The hypotensive effect of depressor, reduces its dosage and toxic and side effects, and earthworm protein is by improving blood quality and Peripheral resistance simultaneously
To hypotension, there is adjustment effect.
(6) reduce blood glucose
Because the optimum positive source comprehensive effect of earthworm protein improves the multiple function of human body, improve the interior environment of body,
Promote the recovery of islet function, have certain blood sugar reducing function.
(7) anti-tumor aspect
Find during with Pheretima extracting solution treatment gastric cancer, this extracting solution has significant inhibitory action to the synthesis of cancerous cell DNA；
After mice with tumor is treated 38 days, result tumor cell is wholly absent.Also have many many with regard to being treated with earthworm protein over the years
Plant cancer patient and all obtain the clinical report of certain curative effect.This all illustrates some chemical compositions contained by earthworm protein to cancer
Swollen cell has very strong Inhibited differentiation and killing action.Or because of some activation factors relieve cancer patient because
Cancer cells secrete cancer coagulates the human blood hypercoagulability that the factor causes, thus playing blood circulation promoting and blood stasis dispelling, going the therapeutic purposes of dispersing tumor that swell.
The invention provides a kind of blood fat reducing pressed candy, there is good nutritional health function.
Content of the invention
For the deficiencies in the prior art, the technical problem to be solved is to provide a kind of blood fat reducing pressed candy.
For achieving the above object, the adopted technical solution is that：
A kind of blood fat reducing pressed candy, is made up of the raw material of following weight parts：Earthworm protein powder 150-250 part, Fructus Crataegi carry
Take thing 250-350 part, Folium Nelumbinis extract 150-250 part, honey peach fruit powder 500-600 part, peach flavor 5-15 part, sugar alcohol
100-150 part, Microcrystalline Cellulose 50-90 part, hydroxypropyl methyl cellulose 15-25 part, magnesium stearate 10-20 part.
Preferably, described sugar alcohol be hydroxyl isomaltulose, maltotetraose alcohol, one or more mixed in L- Sorbitol
Compound.
Preferably, described sugar alcohol is mixed by hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol, described different
Maltulose alcohol, maltotetraose alcohol, the mass ratio of L- Sorbitol are (1-3)：(1-3)：(1-3).
Blood fat reducing pressed candy of the present invention, is become for primary efficacy with earthworm protein powder, Fructus Crataegi extract with Folium Nelumbinis extract
Point, with sugar alcohol, Microcrystalline Cellulose, hydroxypropyl methyl cellulose as adjuvant, it is eaten for a long time and exempts from blood fat reducing, resisting fatigue, enhancing
The function of epidemic disease power.
The present invention is suitable for crowd.
1st, patients with cerebrovascular disease.
Headache, dizziness, cerebral blood supply insufficiency, insomnia and dreamful sleep, hypomnesis, lacunar infarction, transient apoplexy, after apoplexy
Lose disease, hemiplegia, hemiplegia, facial hemiparalysiss, myasthenia of limbs, numbness of hands and feet, slurred speech, serious aphasia, sialorrhea, vision mould
Paste, eye do etc.
2nd, cardiac
Coronary heart diseases and angina pectoris, myocardial infarction, myocardial ischemia, feeling of oppression and pain in the chest, palpitation and short breath, dyspnea, arrhythmia,
Bradycardia or overrun, atrial fibrillation, hypertension, hyperlipidemia, high blood viscosity, the atherosclerosiss such as premature beat
3rd, three-hypers crowd
Hypertension, hyperlipidemia and dyslipidemia person, diabeticss：The microvascular complications such as the heart, brain, kidney, eye, extremity
4th, other microcirculation disturbance or the obstructed person of blood flow
Varicose veins of the lower extremity, vasculitiss, constipation, sexual disorder, prostatosiss, weak feel cold from cold, trick.
Specific embodiment
Each raw material introduction in embodiment：
Earthworm protein powder, with the selected washing of Pheretima (Lumbricuss), hydrolysis self-dissolving, centrifugation, microfiltration, spray drying, bag
The techniques such as dress are made.The present invention is with reference to number of patent application：201210511002.8 prepared by method shown in middle embodiment 1.
The preparation method of Fructus Crataegi extract is as follows：Add 30kg water to be heated to 95 DEG C in 2kg Fructus Crataegi and be incubated 3 hours, so
Adopt 300 mesh filter-cloth filterings afterwards, obtain first-time filtrate and a filtering residue, a filtering residue is added 30kg water and is heated to 95 DEG C of guarantors
Temperature 1.5 hours, then adopts 300 mesh filter-cloth filterings, obtains secondary filtrate and secondary filtering residue, merges first-time filtrate and secondary filter
Liquid, filtrate is condensed into the thick paste that density is 1.30g/mL (20 DEG C), obtains final product.
The preparation method of Folium Nelumbinis extract is as follows：Add 30kg water to be heated to 95 DEG C in 2kg Folium Nelumbinis and be incubated 3 hours, so
Adopt 300 mesh filter-cloth filterings afterwards, obtain first-time filtrate and a filtering residue, a filtering residue is added 30kg water and is heated to 95 DEG C of guarantors
Temperature 1.5 hours, then adopts 300 mesh filter-cloth filterings, obtains secondary filtrate and secondary filtering residue, merges first-time filtrate and secondary filter
Liquid, filtrate is condensed into the thick paste that density is 1.25g/mL (20 DEG C), obtains final product.
The preparation method of honey peach fruit powder is as follows：2kg honey peach is placed in 60 DEG C of baking oven and is dried 12 hours；By drying
Rear honey peach enucleation, it is crushed to 120 mesh；By pulverize after honey peach at -20 DEG C lyophilization 10 hours；Obtain final product.
Peach flavor, the peach flavor being provided using the taste essence and flavoring agent company limited of Hangzhou taste.
Microcrystalline Cellulose, No. CAS：9004-34-6, the food stage being provided using Henan Qi Nuo food ingredient company limited is micro-
Crystalline cellulose.
Hydroxyl isomaltulose, No. CAS：64519-82-0.
Maltotetraose alcohol, No. CAS：66767-99-5.
L- Sorbitol, No. CAS：6706-59-8.
Hydroxypropyl methyl cellulose, No. CAS：9004-65-3, the food being provided using the permanent bio tech ltd in Guangdong thousand
Grade hydroxypropyl methyl cellulose.
Magnesium stearate, No. CAS：557-04-0, the food grade magnesium stearate being provided using Ling Huxinwang Chemical Co., Ltd..
Embodiment 1
Blood fat reducing pressed candy raw material (weight portion)：200 parts of earthworm protein powder, 300 parts of Fructus Crataegi extract, Folium Nelumbinis extract
200 parts, 558 parts of honey peach fruit powder, 11.5 parts of peach flavor, 118 parts of hydroxyl isomaltulose, 75 parts of Microcrystalline Cellulose, hydroxypropyl
22.5 parts of ylmethyl cellulose, 15 parts of magnesium stearate.
The preparation method of blood fat reducing pressed candy, comprises the following steps：
(1) by earthworm protein powder, Fructus Crataegi extract, Folium Nelumbinis extract, honey peach fruit powder, peach flavor, Isomalt ketone
Sugar alcohol, Microcrystalline Cellulose are with rotating speed for 10 minutes mix homogeneously of 300 revs/min of stirrings；Add hydroxypropyl methyl cellulose to turn
Speed is 10 minutes mix homogeneously of 300 revs/min of stirrings, is pelletized with 16 mesh sieves, obtains wet granular；
(5) wet granular is placed in 50 DEG C of drying baker and is dried 12 hours, with 20 mesh sieve granulate, obtain dry particl；
(6) dry particl addition magnesium stearate is fully mixed, confectionary sheet made by tabletting, every tablet quality 600mg.Implemented
The blood fat reducing pressed candy of example 1.
Embodiment 2
Blood fat reducing pressed candy raw material (weight portion)：200 parts of earthworm protein powder, 300 parts of Fructus Crataegi extract, Folium Nelumbinis extract
200 parts, 558 parts of honey peach fruit powder, 11.5 parts of peach flavor, 117 parts of sugar alcohol, 75 parts of Microcrystalline Cellulose, hydroxypropyl methyl fine
Dimension plain 22.5 parts, 15 parts of magnesium stearate.
Described sugar alcohol is 1 by hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol in mass ratio：1：1 stirring mixing
Uniformly obtain.
The preparation method of blood fat reducing pressed candy, comprises the following steps：
(1) by earthworm protein powder, Fructus Crataegi extract, Folium Nelumbinis extract, honey peach fruit powder, peach flavor, sugar alcohol, crystallite
Cellulose is with rotating speed for 10 minutes mix homogeneously of 300 revs/min of stirrings；Add hydroxypropyl methyl cellulose with rotating speed for 300 turns/
Divide stirring 10 minutes mix homogeneously, pelletized with 16 mesh sieves, obtain wet granular；
(5) wet granular is placed in 50 DEG C of drying baker and is dried 12 hours, with 20 mesh sieve granulate, obtain dry particl；
(6) dry particl addition magnesium stearate is fully mixed, confectionary sheet made by tabletting, every tablet quality 600mg.Implemented
The blood fat reducing pressed candy of example 2.
Embodiment 3
Substantially the same manner as Example 2, differ only in：Described sugar alcohol presses matter by maltotetraose alcohol, L- Sorbitol
Amount ratio is 1：1 is uniformly mixed and obtains.Can be prepared by the blood fat reducing pressed candy of embodiment 3.
Embodiment 4
Substantially the same manner as Example 2, differ only in：Described sugar alcohol is pressed by hydroxyl isomaltulose, L- Sorbitol
Mass ratio is 1：1 is uniformly mixed and obtains.Can be prepared by the blood fat reducing pressed candy of embodiment 4.
Embodiment 5
Substantially the same manner as Example 2, differ only in：Described sugar alcohol is pressed by hydroxyl isomaltulose, maltotetraose alcohol
Mass ratio is 1：1 is uniformly mixed and obtains.Can be prepared by the blood fat reducing pressed candy of embodiment 5.
Embodiment 6
Blood fat reducing pressed candy raw material (weight portion)：400 parts of Fructus Crataegi extract, 300 parts of Folium Nelumbinis extract, honey peach fruit powder
558 parts, 11.5 parts of peach flavor, 117 parts of sugar alcohol, 75 parts of Microcrystalline Cellulose, 22.5 parts of hydroxypropyl methyl cellulose, stearic acid
15 parts of magnesium.
Described sugar alcohol is 1 by hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol in mass ratio：1：1 stirring mixing
Uniformly obtain.
The preparation method of blood fat reducing pressed candy, comprises the following steps：
(1) by Fructus Crataegi extract, Folium Nelumbinis extract, honey peach fruit powder, peach flavor, sugar alcohol, Microcrystalline Cellulose to turn
Speed is 10 minutes mix homogeneously of 300 revs/min of stirrings；Add hydroxypropyl methyl cellulose and stir 10 points with rotating speed for 300 revs/min
Clock mix homogeneously, is pelletized with 16 mesh sieves, obtains wet granular；
(5) wet granular is placed in 50 DEG C of drying baker and is dried 12 hours, with 20 mesh sieve granulate, obtain dry particl；
(6) dry particl addition magnesium stearate is fully mixed, confectionary sheet made by tabletting, every tablet quality 600mg.Can be prepared by
The blood fat reducing pressed candy of embodiment 6.
Embodiment 7
Blood fat reducing pressed candy raw material (weight portion)：350 parts of earthworm protein powder, 350 parts of Folium Nelumbinis extract, honey peach fruit powder
558 parts, 11.5 parts of peach flavor, 117 parts of sugar alcohol, 75 parts of Microcrystalline Cellulose, 22.5 parts of hydroxypropyl methyl cellulose, stearic acid
15 parts of magnesium.
Described sugar alcohol is 1 by hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol in mass ratio：1：1 stirring mixing
Uniformly obtain.
The preparation method of blood fat reducing pressed candy, comprises the following steps：
(1) by earthworm protein powder, Folium Nelumbinis extract, honey peach fruit powder, peach flavor, sugar alcohol, Microcrystalline Cellulose to turn
Speed is 10 minutes mix homogeneously of 300 revs/min of stirrings；Add hydroxypropyl methyl cellulose and stir 10 points with rotating speed for 300 revs/min
Clock mix homogeneously, is pelletized with 16 mesh sieves, obtains wet granular；
(5) wet granular is placed in 50 DEG C of drying baker and is dried 12 hours, with 20 mesh sieve granulate, obtain dry particl；
(6) dry particl addition magnesium stearate is fully mixed, confectionary sheet made by tabletting, every tablet quality 600mg.Can be prepared by
The blood fat reducing pressed candy of embodiment 7.
Embodiment 8
Blood fat reducing pressed candy raw material (weight portion)：300 parts of earthworm protein powder, 400 parts of Fructus Crataegi extract, honey peach fruit powder
558 parts, 11.5 parts of peach flavor, 117 parts of sugar alcohol, 75 parts of Microcrystalline Cellulose, 22.5 parts of hydroxypropyl methyl cellulose, stearic acid
15 parts of magnesium.
Described sugar alcohol is 1 by hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol in mass ratio：1：1 stirring mixing
Uniformly obtain.
The preparation method of blood fat reducing pressed candy, comprises the following steps：
(1) by earthworm protein powder, Fructus Crataegi extract, honey peach fruit powder, peach flavor, sugar alcohol, Microcrystalline Cellulose to turn
Speed is 10 minutes mix homogeneously of 300 revs/min of stirrings；Add hydroxypropyl methyl cellulose and stir 10 points with rotating speed for 300 revs/min
Clock mix homogeneously, is pelletized with 16 mesh sieves, obtains wet granular；
(5) wet granular is placed in 50 DEG C of drying baker and is dried 12 hours, with 20 mesh sieve granulate, obtain dry particl；
(6) dry particl addition magnesium stearate is fully mixed, confectionary sheet made by tabletting, every tablet quality 600mg.Can be prepared by
The blood fat reducing pressed candy of embodiment 8.
Test case 1
By the blood fat reducing pressed candy of embodiment 2-8 preparation, it is placed in 25 DEG C, preservation half a year under relative humidity 85% environment,
Then carry out the test of escherichia coli (ATYCC 25922) total plate count, with reference to GBT 4789.2-2008 food hygiene microbiology
Inspection total plate count measures.Concrete test result is shown in Table 1.
Table 1：Total plate count tests table
| E. coli clones sum, cfu/g | |
| Embodiment 2 | 581 |
| Embodiment 3 | 994 |
| Embodiment 4 | 1013 |
| Embodiment 5 | 935 |
| Embodiment 6 | 746 |
| Embodiment 7 | 925 |
| Embodiment 8 | 796 |
Comparing embodiment 2 and embodiment 3-5, (hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol are multiple for embodiment 2
Join) antiseptic property apparently higher than embodiment 3-5 (in hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol any two kinds multiple
Join)；Comparing embodiment 2 and embodiment 6-8, embodiment 2 (earthworm protein powder, Fructus Crataegi extract, Folium Nelumbinis extract compound) is anti-corrosion
Performance is apparently higher than embodiment 6-8 (in earthworm protein powder, Fructus Crataegi extract, Folium Nelumbinis extract any two kinds compound).
Test case 2
In order to preferably verify the curative effect of the present invention, the blood fat reducing pressed candy using the preparation of embodiment of the present invention 2-8 enters
Row clinical observation is studied, and to further illustrate the present invention to the curative effect reducing blood pressure.
Clinical data
Using the principle of voluntariness, every group selection outpatient 50, wherein man 25, female 25, max age 60 years old, minimum
At 18 years old age, clinical manifestation is hypertension.
Experimental technique：The present invention through 7 groups of clinical verifications, respectively using the blood fat reducing pressed candy of embodiment 2-8 preparation, often
8 points of its morning, at 5 points in afternoon take two respectively.Collect patient after two weeks using blood pressure data in front and back, carry out statistics more afterwards
Analysis, result shows P ＜ 0.05, and difference has statistical significance.Concrete test data is shown in Table 2.
Table 2：Pressure value tests table
Comparing embodiment 2 and embodiment 3-5, (hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol are multiple for embodiment 2
Join) blood pressure lowering effect be substantially better than embodiment 3-5 (in hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol any two kinds multiple
Join)；Comparing embodiment 2 and embodiment 6-8, embodiment 2 (earthworm protein powder, Fructus Crataegi extract, Folium Nelumbinis extract compound) fall blood
Pressure effect is substantially better than embodiment 6-8 (in earthworm protein powder, Fructus Crataegi extract, Folium Nelumbinis extract, any two kinds compound).
Test case 3
Stability test is carried out to the blood fat reducing pressed candy of embodiment 2-5 preparation.
The earthworm protein comprising in blood fat reducing pressed candy of the present invention is the index composition of blood fat reducing pressed candy.Will be real
Apply the prepared blood fat reducing pressed candy of a 1-6 and use aluminum-plastic composite membrane bag hermetic package respectively, they are placed in 38 DEG C of temperature decentralizations
Put 3 months, measure earthworm protein during March in each sample with respect to residual content during this sample 0 month.Method of testing is with reference to Yan
Duckweed etc.《The research of Various Methods for Determing Different Proteins in earth-worm extractive as raw material》.Concrete outcome is shown in Table 3.
Table 3：Stability test result table
| Earthworm protein residual content, % | |
| Embodiment 2 | 99.5 |
| Embodiment 3 | 95.7 |
| Embodiment 4 | 92.8 |
| Embodiment 5 | 94.3 |
Comparing embodiment 2 and embodiment 3-5, (hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol are multiple for embodiment 2
Join) stability is substantially better than embodiment 3-5 (in hydroxyl isomaltulose, maltotetraose alcohol, L- Sorbitol any two kinds compound).
Claims (3)
1. a kind of blood fat reducing pressed candy is it is characterised in that be made up of the raw material of following weight parts：Earthworm protein powder 150-250
Part, Fructus Crataegi extract 250-350 part, Folium Nelumbinis extract 150-250 part, honey peach fruit powder 500-600 part, peach flavor 5-15
Part, sugar alcohol 100-150 part, Microcrystalline Cellulose 50-90 part, hydroxypropyl methyl cellulose 15-25 part, magnesium stearate 10-20 part.
2. blood fat reducing pressed candy as claimed in claim 1 is it is characterised in that described sugar alcohol is hydroxyl isomaltulose, wheat
One or more of mixture in bud four sugar alcohol, L- Sorbitol.
3. blood fat reducing pressed candy as claimed in claim 2 is it is characterised in that described sugar alcohol is by hydroxyl isomaltulose, wheat
Bud four sugar alcohol, L- Sorbitol mix, and described hydroxyl isomaltulose, maltotetraose alcohol, the mass ratio of L- Sorbitol are
(1-3)：(1-3)：(1-3).
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| CN201610995604.3A CN106474219A (en) | 2016-11-11 | 2016-11-11 | Blood fat reducing pressed candy |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610995604.3A CN106474219A (en) | 2016-11-11 | 2016-11-11 | Blood fat reducing pressed candy |
Publications (1)
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| CN106474219A true CN106474219A (en) | 2017-03-08 |
Family
ID=58271969
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| CN108029842A (en) * | 2017-12-15 | 2018-05-15 | 阜阳健诺生物科技有限公司 | A kind of tea polyphenols pressed candy and preparation method thereof |
| CN108065015A (en) * | 2017-11-27 | 2018-05-25 | 余雪平 | Reducing blood lipid pressed candy of the dragon protein containing ground and preparation method thereof |
| CN108835634A (en) * | 2018-06-07 | 2018-11-20 | 无限极（中国）有限公司 | Composition and preparation method thereof, application |
| CN109043097A (en) * | 2018-08-20 | 2018-12-21 | 烟台盼圣汇食品有限公司 | A kind of compound pressed candy of sea cucumber Poria cocos fructus lycii and preparation method thereof |
| CN109315576A (en) * | 2018-10-12 | 2019-02-12 | 肖文中 | Natto bamboo-leaves flavones pressed candy |
| CN111357858A (en) * | 2019-09-18 | 2020-07-03 | 广州市好孝心医疗器械有限公司 | Composite polypeptide earthworm protein tablet candy with thrombus dissolving and blood vessel softening functions and preparation method thereof |
| CN111758830A (en) * | 2020-07-08 | 2020-10-13 | 天津蚓福生物科技开发有限公司 | Blood fat reducing antioxidant tabletting candy |
| CN114343043A (en) * | 2022-01-13 | 2022-04-15 | 广东净沙生物科技有限公司 | Compound tablet candy for preventing and treating vascular diseases and preparation method thereof |
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| CN111758830A (en) * | 2020-07-08 | 2020-10-13 | 天津蚓福生物科技开发有限公司 | Blood fat reducing antioxidant tabletting candy |
| CN111758830B (en) * | 2020-07-08 | 2022-03-29 | 天津蚓福生物科技开发有限公司 | Blood fat reducing antioxidant tabletting candy |
| CN114343043A (en) * | 2022-01-13 | 2022-04-15 | 广东净沙生物科技有限公司 | Compound tablet candy for preventing and treating vascular diseases and preparation method thereof |
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Application publication date: 20170308 |