The content of the invention
The purpose of the present invention one there is provided a kind of formula of Suya Pink antihyperlipemic tea, another purpose
There are provided a kind of preparation method of Suya Pink antihyperlipemic tea.
The effects such as product has auxiliary blood fat reducing blood pressure lowering, is suitable to hypertension, hyperlipemic patients
Drink, patient's life quality can be effectively improved.Hyperlipidemia belongs in the traditional Chinese medical science that expectorant is turbid, blood stasis model
Farmland.Basic Theories of Chinese Medicine thinks that the imbalance of liver,kidney,spleen organ function produces root of life for hyperlipidemia,
And the turbid blood stasis of expectorant is the mark of hyperlipidemia;Raw obstruction arteries and veins in phlegm retention turbid damp, stagnation of QI stasis of blood product, phlegm-blood stasis
Road, turbid YIN failing to descend and clear YANG failing to ascend are the key pathological bases for producing hyperlipidemia.The present invention with
For the purpose of conditioning liver,kidney,spleen function balance, the integration of edible and medicinal herbs class with hypolipemic function is selected
Article carries out scientific composition according to Chinese prescription combination principle and Suya Pink black tea, and takes its activity
Components compatibility is used as medicine to strengthen its curative effect.
For achieving the above object, technical scheme is as follows:
1st, a kind of Suya Pink antihyperlipemic tea, it is characterised in that the Suya Pink lipid-loweringing of every 1000 weight portion
Tea is made up of the raw material of following weight portion:6~22 weight of Suya Pink antihyperlipemic tea Radix Puerariae containing Chinese crude drug
It is part, 3~15 weight portion of Radix Scutellariae, 3~15 weight portion of Rhizoma Coptidis, 15~30 weight portion of Fructus Rosae Laevigatae, white
Really 2~12 weight portions, 20~30 weight portion of Fructus Crataegi, 15~20 weight portion of Semen Cassiae, Fructus Lycii 10~
15 weight portions, 10~15 weight portion of Folium Nelumbinis, 8~10 weight portion of Radix Polygoni Multiflori, 8~10 weight of Rhizoma Alismatis
Part, 5~10 weight portion of Flos Chrysanthemi, 3~5 weight portion of Radix Glycyrrhizae Preparata.
2nd, described a kind of Suya Pink antihyperlipemic tea, its preparation method are characterised by including following work
Skill step:
1., by 6~22 weight portion of Chinese crude drug Radix Puerariae described in step 1,3~15 weight portion of Radix Scutellariae,
3~15 weight portion of Rhizoma Coptidis, 15~30 weight portion of Fructus Rosae Laevigatae, 2~12 weight portion of Semen Ginkgo, Fructus Crataegi 20~
30 weight portions, 15~20 weight portion of Semen Cassiae, 10~15 weight portion of Fructus Lycii, 10~15 weight of Folium Nelumbinis
Amount part, 8~10 weight portion of Radix Polygoni Multiflori, 8~10 weight portion of Rhizoma Alismatis, 5~10 weight portion of Flos Chrysanthemi, process
3~5 weight portion of Radix Glycyrrhizae through picking pick, clean, be dried after put into into super micron mill, crush
It is standby into 20~220 mesh superfine powder.
2., by 1~15% above-mentioned Chinese crude drug superfine powder and the Suya Pink black tea of 85~99 weight portions
Mix homogeneously.
3. above-mentioned material by evenly mixing is placed in into moistening 3~24 hours in stainless steel cask,.
4. 3. described material is taken out, is dried, pack, as ultraviolet-sterilization, finished product.
In above-mentioned compatibility, Radix Puerariae is the dry root of legume pueraria lobata or Radix puerariae rattan, begins to carry
In《Sheng Nong's herbal classic》, it is listed in middle product.The pharmacological action of Radix Puerariae or Radix Puerariae monomeric compound
Extensively, mainly have it is following some:1. antiinflammatory action:Puerarin can substantially suppress proinflammatory cytokine
The factor, I NF-a and I L-6 are produced, and there is obvious protective function n to draw obstructive jaundice rats.
2. improve motor capacity:Puerarin can reduce the hemoglobin caused because of training rising,
Increasing for platelet count and RBC number, extends the time that power exhausts swimming, reduces the viscosity of blood,
Improve the motor capacity of body.3. on cardiovascular impact:Puerarin can significantly reduce ischemia and draw
The generation of myocardial lactate is played, mitigates Myocardial Ischemia-reperfusion oxygen consumption and myocardial water content.May be used also
Be obviously improved normal gold suslik brain microcirculation, to local due to norepinephrine cause it is micro-
Circulatory disturbance is all significantly improved effect, slightly improves cerebral circulation and peripheral circulation.Radix Puerariae has
One of effect composition Radix Puerariae total flavoness act on more obvious than coronary artery to cerebral vasodilators, can delay
Slowly improve cerebral circulation and peripheral circulation.Separately there is document report, myocardial ischemia can cause sodium ion
The change of current amplitude, this change can affect the conduction velocity of cardiac impulse, and then cause the heart
Rule is not normal.And puerarin can reach the treatment rhythm of the heart and lose by blocking myocardial cell sodium-ion channel
Normal effect.In addition Radix Puerariae also has blood sugar lowering, antioxidation etc. to act on.
Radix Scutellariae, begins to be loaded in《Sheng Nong's herbal classic》, return Cao Bushan grass classes, be classified as middle product, be lip
The dry root of shape section perennial plant Radix Scutellariae.The pharmacological action master of Radix Scutellariae or Radix Scutellariae monomeric compound
Have:Antiinflammatory, anti-allergic effects:The radio immunoassay (RIA) such as Hou Shi, efficient liquid phase
Chromatography (HPLC) and fluorescence spectrophotometry baicalin are to rat abdominal cavity cyclic adenosine monophosphate
(cAMP), in leukocyte leukotriene (LTs) and free Ca 2+level impact, show Huang
A kind of reed mentioned in ancient books glycosides can significantly inhibit ca2+ in the leukocyte that artificial tripeptides (fIVILP) is excited and raise, and can also show
Write and suppress intracellular leukotriene C, the biosynthesiss of leukotriene B4, while promoting intracellular cAMP
Level is improved, and is shown that baicalin can significantly affect the several functions of leukocyte, and is disclosed its antiinflammatory
The mechanism of action.Baicalin adjusts immune system, antithrombotic effect with reducing blood pressure.
Baicalin has protective effect to cerebral ischemia reperfusion injury, effectively extends the survival of patients time,
Abnormal behavior can be significantly improved, malonaldehyde (MDA) content in impaired cerebral tissue is reduced, is improved
The extensive pharmacological action of superoxide dismutase content.
Rhizoma Coptidis:Beginning is loaded in《Sheng Nong's herbal classic》, top grade is classified as, various Rhizoma Coptidis root and rhizomes are equal
Containing the different types of isoquinoline alkaloid of many kinds, berberine is the principle active component of Rhizoma Coptidis,
Content accounts for the 5%~8% of total alkaloidss.Different types of Rhizoma Coptidis effective ingredient is also differed,
Tens of kinds of different types of alkaloid components have been obtained so far.
Rhizoma Coptidis toxic materials clearing away decoction can suppress granulocytic in air sac models of synovitis in mice to be swum out of and fatty polysaccharide thorn
Sharp macrophage generates nitric oxide and interleukin 1.Film is respectively provided with to hemocyte and tissue simultaneously
Protective effect.Hyperlipidemia is also had significant therapeutic effect.
Fructus Rosae Laevigatae:Beginning is loaded in《Another name for Sichuan Province book on Chinese herbal medicine》,《Compendium of Materia Medica》Described in Fructus Rosae Laevigatae it is sour, puckery,
It is flat, nontoxic:The splenic diarrhea dysentery is cured mainly, only normal urination, arresting seminal emission gas;Long term usage, makes us cold-resistant and makes light of one's life by commiting suicide,
Enriching blood and replenishing vital essence, has special effect.The research such as Zhang Tingyan finds that Fructus Rosae Laevigatae polysaccharides can suppress gallbladder in intestinal
The absorption of sterin.There are certain prevention and treatment to Experimental Mice hypercholesterolemia.
The content of blood cholesterol is in negative correlation with the addition of Fructus Rosae Laevigatae polysaccharides, but to triglyceride
Effect not substantially, illustrate that the effect for reducing fat mechanism of Fructus Rosae Laevigatae polysaccharides is mainly to cholesterol rather than sweet
Oily three esters.
Semen Ginkgo:Containing rich in protein, fat, saccharide, crude fibre, and there is a small amount of dimension
Raw element B1, vitamin B2, and the mineral such as potassium, ferrum, calcium, phosphorus.《Compendium of Materia Medica》Note
Carry:" prepared food warming the lung, QI invigorating, Dingchuan, eat raw drop expectorant, disinfection ", with very high
Edibility and medical value.Semen Ginkgo has abundant nutritional labeling, has medicine to eat with work(feature.
First-selected Semen Ginkgo can prevent cardiovascular and cerebrovascular disease, and which has blood circulation promoting and blood stasis dispelling, prevent thrombosiss, drop
Low blood coagulation degree, removes free radical, delays arteriosclerosis progress.
Fructus Crataegi:Fructus Crataegi is parts of generic medicinal plants, the main chemistry such as organic acid containing flavonoid and triterpeness
Composition.Effect of crataegus pin natifida var. Major is promoting digestion and invigorating the stomach. blood fat reducing.Hyperin, ursolic acid are that Fructus Crataegi is yellow
The main component of ketone and triterpene substance.Document report haw flavonoids substances have blood pressure lowering, increase
Plus coronary flow, blood fat reducing, heart tonifying and antiarrhythmic pharmacological action.And triterpeness into
Dividing plays the role of to reduce hyperlipidemia model lipid of mice.Ursolic acid be Fructus Crataegi triterpenoid it is main into
Point, with antioxidation and effect for reducing blood fat, laboratory observation is significantly reduced to both compounds
High fat mice serum TCH, rising HDL/TCH ratios, illustrate which has reduction cholesterol, adjust
The effect of blood fat.And all there is the effect for improving lipidemia and mice serum sOD activity, this work
With damage of the superoxide radical to blood vessel endothelium when can substantially reduce hyperlipemia, be conducive to
The decomposition and metabolism of lipid oxide, to protect blood vessel endothelium.Experiment shows ursolic acid and Radix Hyperici Monogyni (Herba Hyperici Monogyni)
Glycosides has, adjusts blood fat and improve the drug action of activity of SOD in serum,
These effects prevent vascular endothelial injury for treatment hyperlipemia, prevent blood vessel scleratheroma
Formation have important meaning.He Qiuyan is " Fructus Crataegi extract is to atherosclerotic anti-
Control effect " research in think, Fructus Crataegi it is existing to oxLDL damage HMEC prevention effect, also have
Tune fat function to Experimental Hyperlipemia blood rat.Experiment confirms its antioxidation and prevents and treats hyperlipemia
Effect, be also that antioxidant content in natural product is removed free radical, further elucidates tremulous pulse
Atherosis Forming Mechanism provides foundation.Li Xiaomei is in " Fructus Jujubae Fructus Crataegi prescription antioxidation in vitro
With internal Adjust-blood lipid activity research " middle confirmation, antioxidation activity in vitro:In each extract of Fructus Crataegi
The ability that SC removes free radical is most strong;In each extract of Fructus Jujubae, the ability of DC removings free radical is most strong.
DC+SE, SD+DC, SC+DD and SD+DA have synergism for removing DPPH free radicals;
SB+DC, SC+DA, DW+SC and DW+SE have synergism for removing ABTS free radicals.Greatly
Fructus Jujubae has Adjust-blood lipid and strengthens lipoid peroxidization resistant to hyperlipemia in mice.DY and DW are big
The effective site of Fructus Jujubae Adjust-blood lipid, DD are the effective site of Adjust-blood lipid in DY;Fructus Crataegi extract for
The Adjust-blood lipid level of hyperlipidemia mice is consistent with anti peroxidation of lipid ability performance is strengthened.Show
SC is the effective site of Fructus Crataegi Adjust-blood lipid and anti peroxidation of lipid.SC+DD、SC+DB、SC+DC、
SB+DC, SC+DA, SC+DW, SE+DW have association for internal Adjust-blood lipid and anti peroxidation of lipid
Same-action.
Semen Cassiae:Beginning is loaded in《Sheng Nong's herbal classic》, nature and flavor are sweet, bitter, into, be slightly cold, Return liver,
Large intestine channel.With liver heat removing tomorrow, loosening bowel to relieve constipation, lowering blood pressure and blood fat, liver protection and suppression mattress etc.
Effect.Semen Cassiae is abundant in china natural resources, not only with extensive medical value, but also is
Preferable health care medicine, has preferable therapeutical effect to numerous disease simply.Demonstrate,prove under study for action
Real, the formation of Semen Cassiae powder and its solvent subsection extracts to hyperlipemia has preventive effect,
This effect strengthens with the increase of Extraction solvent polarity.With hyperlipemia animal model as itself
Control, the initial gross separation from cassia seed water extract go out mixture C, and the material can significantly reduce high fat
TC, TG in mass formed by blood stasis animal serum, and HDL is improved, there is remarkable result to treating hyperlipemia.
In the research of Semen Cassiae extract effect for reducing fat, experiment is first using animal from as right
According to, first set up hyperlipemia animal model, to can not set up hyperlipemia model animal in addition
Eliminate, add medicine afterwards.What experimental result was disclosed is therapeutical effect of the medicine to hyperlipemia.
Fructus Lycii:Drying of the Fructus Lycii for plant of Solanaceae lycium barbarum Lycium barbarum L.
Mature fruit.The traditional Chinese medical science thinks its property sweet taste, returns liver and kidney channel, with nourishing liver and kidney, benefit essence
Effect of improving eyesight, cures mainly consumption consumptive loss, soreness of waist and knee joint, vertigo and tinnitus, Heat Diabetes, blood deficiency
Sallow, blurred vision.Modern medicine proves that Fructus Lycii has antioxidation, defying age, enhancing
The multiple biological activities such as immunologic function and antitumor.It is also many containing abundant Fructus Lycii in Fructus Lycii
Sugar, pigment, aminoacid, trace element, vitamin,
Fat and fatty acid, alcohols and inorganic salt etc..Modern pharmacology research shows that Fructus Lycii has wide
General biologic activity, including antioxidation, anti-aging effects, improving eyesight, hepatoprotective effect,
Effect for reducing blood fat, antitumor action and the adjustment effect to cellular immune function etc..Jiang Qingru etc.
Research finds that LBP can reduce hyperlipidemia ratses Vascular Smooth Muscle Cell Apoptosis rate, delays tremulous pulse athero-
The generation of hardening.Jiang Qing in 2010 eats etc. and to prove that LBP can reduce hyperlipemia by zoopery
Rat fat triglyceride, T-CHOL and low-density lipoprotein white level, improve hyperlipemia big
The oxidative stress status of Mus aorta, delay atherosclerotic generation.
Folium Nelumbinis:Beginning is loaded in Meng's numerous Tang Dynasty《Treatise on Dietetic Therapy》, go through version《Chinese Pharmacopoeia》Also have
Record;Property bitter, flat, Return liver, spleen, stomach:With clearing away summer-heat, sending up the lucid YANG, removing heat from blood
The effect of hemostasis.Model is graceful to be found in lotus leaf alkaloid class material lowering blood-fat and reducing weight activity research, body
Interior test confirms that lotus leaf alkaloid class material has obvious functions of lowering blood-fat and reducing weight.Hyperlipemia
After disease rat is administered 40 days, reflect growth figure such as Lee ' S indexes, the body of body obese degree
Fat and blood lipid level have and decline to some extent.With increasing for lotus leaf alkaloid dosage, greatly
The weight of Mus, each internal organs quality, Lee ' S indexes, body fat coefficient decline more obvious, high dose
The reducing effect of group is closest to medicine group.Middle dosage lotus leaf alkaloid extract group rat blood serum
TC, TG, LDL, AI, ALT and AST level are significantly reduced, effect also close to medicine group,
Middle dosage lotus leaf alkaloid extract has significant rising trend to HDL, and its effect is more prominent than medicine group
Go out.Therefore, we are it is believed that lotus leaf alkaloid class material has control body weight, prevention fertilizer
It is fat, adjust effect of disorders of lipid metabolism.Du Lijun etc. observes Folium Nelumbinis water extraction by internal and external test
Take impact of the thing to serum gallbladder I department's alcohol and triacylglycerol.Acute hyperlipemia mice block mold is tied
Fruit shows:The triacylglycerol (1 ' G) of lotus flavone, alkaloid moiety to acute hyperlipemia mice
There is obvious inhibitory action.Lotus flavone shows obvious inhibitory action to mice hypercholesterolemia.
Tao Bo etc. observes Folium Nelumbinis water decoction to hyperlipidemia ratses blood fat and hemorheological impact,
It has also been found that Folium Nelumbinis decoct can reduce hyperlipidemia ratses TC, TG, low density lipoprotein, LDL and improve
The dense viscous state of hyperlipidemia ratses blood.
Radix Polygoni Multiflori:Effect for reducing blood fat and medicine of the Wang Chunying in Stilbene Glucoside In Polygonum Multiflorum
Prove that Radix Polygoni Multiflori has significant blood fat reducing and atherosclerosiss in the research of thing dynamic metabolism
Deng effect, such as 95% ethanol extraction energy blood fat reducing of Radix Polygoni Multiflori Preparata and delay atherosclerotic shape
Into and development.2,3,5,4 ', tetrahydroxystilbene .2.0.p.D. glucoside (abbreviation hexichol
Ethylene glycosides, TSG) for the primary water-soluble composition of Chinese medicine Radix Polygoni Multiflori.
Wherein TSG is the main active of Chinese medicine Radix Polygoni Multiflori regulating blood lipid action.Radix Polygoni Multiflori extract can
Suppress the apoptosis of vascular endothelial cell of In vitro culture, and Endothelial Cell Growth Cultured in vitro can be raised
Total antioxidant capacity and NO levels, the vigor for improving SOD simultaneously lowers LPO levels, thus it is speculated that He Shou
Black extract has protective effect to Endothelial Cell Growth Cultured in vitro.Fang Wei etc. observes Radix Polygoni Multiflori
The impact that total glycosides are formed with mice As pathological changes to ApoE, it is found that ApoE gene-deficient mice may pass through antioxygen
Change protection aortic endothelial cell form, reduce ApoE.Mice OX.LDL, reduction aorta wall
The expression of NF.r.B, so as to lower the links such as the expression of aorta wall ICAM.1 and VCAM-1
Delay the formation of Aortic Plaque, playing prevents ApoE bucket mouse experiment Atheromatosises
The effect being deformed into.
Rhizoma Alismatis:Rhizoma Alismatis return kidney and bladder warp, promoting diuresis to eliminate damp pathogen to expel the heat-evil, and make the wet accumulation of water from urine
And go out, with phlegm retention processed.The bravely confirmation in " ZEXIE TANG effect for reducing blood fat study mechanism " of happy intelligence,
Rhizoma Alismatis have functions that to reduce serum high-density LP, cholesterol and serum triacylglycerol,
And acting on notable, Rhizoma Alismatis also have functions that to suppress aortic tunica intima speckle to generate.The effect can
Can be the effect for improving reverse cholesterol transport with Rhizoma Alismatis extract, in making speckle, cholesterol is not
Transport liver disconnectedly to, and be constantly decomposed and metabolism in liver, so as to suppress speckle to give birth to
Into.Rhizoma Alismatis extract is to being caused due to the acid of Low protein diet, carbon tetrachloride and ethyl thiamine
Rats adiposis hepatica there is different degrees of suppression effect;Also there are some researches show that Rhizoma Alismatis ethanol is extracted
The content of rabbit liver fat of the thing to being caused using high lipid food has more significant ground inhibitory action.
Flos Chrysanthemi:For China's conventional Chinese medicine, the effect of with wind and heat dispersing, flat liver improving eyesight.It is modern
Pharmaceutical research shows that Flos Chrysanthemi has antiinflammatory, antioxidation, antitumor, vasodilator and liver protection etc.
Multiple pharmacological effect.Cui Yan suppresses mice high-fat fatty liver to be formed and its machine in Flos Chrysanthemi extract
In system research, the impact to PPAR alpha expressions after animal is administered, and the target gene to it are determined
The impact of SREBP-1c, FAS, DGAT, LPL and CYP7A1 expression.By the BRL of In vitro culture
Liver cell line, directly observes shadow of the Flos Chrysanthemi extract of Contained Serum to hepatocyte PPAR alpha expressions
Ring, and the shadow of target gene SREBP-1c, FAS, DGAT, the LPL and CYP7A1 expression to it
Ring, and utilize PPAR alpha-2 antagonists, further determine that the Regulation serum lipids mechanism of Flos Chrysanthemi extract is
It is no by PPAR α approach realize.Fu Weilin;In the extraction purification of Flos Chrysanthemi flavone and its to fat
Confirm in the research of metabolism disorder rat effect, compared with hyperlipidemia model matched group, Flos Chrysanthemi flavone
Tested material can reduce disorders of lipid metabolism rat TG, TC, LDL-C, NEFA level, increasing serum HDL
- C this sub- level in protectiveness ridge, and it is active to significantly improve LPL, reduces ApoB levels,
Mitigate hepatic steatosis degree, mitigate Aortic arch atherosclerosis degree, effect is with Chrysan Yellow
Ketone high dose group is the most obvious, and it is more preferable to enclose the impact of alcohol metabolism from the results of view to gallbladder.Together
When RT-PCR results show that Flos Chrysanthemi flavone can increase the expression water of PPARymRNA in fatty tissue
It is flat, so as to play the adjustment effect to disorders of lipid metabolism.
Radix Glycyrrhizae, begins to be loaded in《Sheng Nong's herbal classic》, it is classified as top grade.Its it is mutually coordinated in side can
Body nerve-endocrine function is adjusted, acting on multisystem, multiple organ, Mutiple Targets makes body cloudy
Sun is coordinated, and so as to reduce blood viscosity, antiplatelet aggregation significantly improves blood lipid level.
Improving blood circulation and reducing fat tea can prevent and treat the generation of patients with dyslipidemia cardiovascular and cerebrovascular disease well, and facilitate Jing
Ji, can promote in clinical practice.The benign species such as high density fat, do not drop in energy reduction blood fat,
Have no toxic side effect.Because the relevant disease that blood fat causes has good assosting effect.