CN105943514A - Glipizide tablets for treating diabetes and preparation method thereof - Google Patents
Glipizide tablets for treating diabetes and preparation method thereof Download PDFInfo
- Publication number
- CN105943514A CN105943514A CN201610457314.3A CN201610457314A CN105943514A CN 105943514 A CN105943514 A CN 105943514A CN 201610457314 A CN201610457314 A CN 201610457314A CN 105943514 A CN105943514 A CN 105943514A
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- Prior art keywords
- glipizide
- tablet
- diabetes
- stirring
- stirring paddle
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/074—Stirrers characterised by their mounting on the shaft having two or more mixing elements being concentrically mounted on the same shaft
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
- B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
- B01F27/11251—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis having holes in the surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
- B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/21—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by their rotating shafts
- B01F27/2122—Hollow shafts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to glipizide tablets for treating diabetes, belonging to the technical field of Western medicine preparations. The glipizide tablets consist of the following components: 5-15 parts of glipizide, 20-40 parts of hydroxypropyl methyl cellulose, 30-50 parts of calcium carbonate and the like; and the components are mixed by a specific particle stirrer. The tablets provided by the invention are stably and slowly released.
Description
Technical field
The invention belongs to Western medicine preparation technical field, particularly to a kind of glipizide tablet treating diabetes.
Background technology
Glipizide tablet, it is adaptable to through diet control and physical training 2-3 unsatisfied light, the moderate II type of month curative effect
Diabetics, the beta Cell of islet of this kind of diabetics need to have certain excreting insulin function, and without acute also
Sending out disease (such as infections, wound, ketoacidosis, hyperosmolar coma etc.), nonjoinder is pregnant, without serious chronic concurrently
Disease.Existing glipizide tablet all uses compressing dry granulation technique or uses the methods such as inclusion to increase the stability of preparation, and dissolution is not
Stable, usually produce some side effect when patient takes clinically.
Summary of the invention
In order to overcome the deficiencies in the prior art, adjuvant screening, process optimization and equipment are improved by the present invention by lot of experiments,
Provide a kind of glipizide tablet.This tablet slow release, gastrointestinal side-effect are little, and preparation technology is simple.
The object of the present invention is achieved like this:
A kind of glipizide tablet treating diabetes, by tablet total weight amount percentages, consists of the following composition: lattice arrange
Pyrazine 5-15 part, hydroxypropyl methyl cellulose 20-40 part, calcium carbonate 30-50 part, ASPARTIC ACID 10-20 part,
Sodium alginate 10-20 part, calcium sulphate dihydrate 15-25 part, guar gum 5-15 part, polyvinylpolypyrrolidone 5-10 part, hard
Fatty acid magnesium 0.5-2.0 part.
The glipizide tablet of described treatment diabetes, the formula of glipizide tablet is as follows: glipizide 10g, hydroxypropyl
Methylcellulose 30g, calcium carbonate 40g, ASPARTIC ACID 15g, sodium alginate 15g, calcium sulphate dihydrate 20g, melon
That locust beam gum 10g, polyvinylpolypyrrolidone 8g, magnesium stearate 1g.
The glipizide tablet of described treatment diabetes, preparation method comprises the following steps: to take glipizide crude drug,
Glipizide crude drug is placed in disintegrating apparatus pulverizing；Glipizide crude drug after pulverizing according to quantity exists with above-mentioned adjuvant
Mix homogeneously in Particle mixer, pelletizes according to a conventional method, tabletting, packs to obtain finished product.
The glipizide tablet of described treatment diabetes, Particle mixer in preparation method, including agitator, it is arranged on institute
State shaft in agitator and be arranged on described agitator the stirring motor being connected with described shaft, stirring described
Mix axle and be provided with stirring paddle, it is characterised in that: on described stirring paddle, it is provided with open-work, the inwall of described open-work is provided with
Annular groove, is provided with ring rotation block in described annular groove, is provided with and described annular groove phase in described stirring paddle
The driving chamber of connection, is provided with micro-machine at described driving intracavity, is provided with driving fluted disc on the main shaft of described micro-machine,
The outer ring surface of described ring rotation block is provided with the teeth groove mutually ratcheting with described driving fluted disc, at described ring rotation block
Be uniformly provided with at least three stirring bar on inner ring surface, described stirring bar under the drive of described micro-machine in described open-work
Stirring.
The glipizide tablet of described treatment diabetes, granule stirs evenly two sides of stirring paddle in device and is horn-like setting
Put and trumpet-shaped center is connected with open-work.
The glipizide tablet of described treatment diabetes, granule stirs evenly shaft in device and is provided with upset motor, described in turn over
The main shaft of rotating motor is connected with the end of described stirring paddle, drives stirring paddle to realize upset behaviour during described upset electric motor starting
Make.
The glipizide tablet of described treatment diabetes, granule stirs evenly stirring cylinder in device and is provided with and described micro-machine
The speed governing knob that the control knob being connected is connected with described upset motor.
Compared with prior art, the glipizide tablet that the present invention relates to has a most useful technique effect:
(1) release is steadily.(2) preparation technology is simple, Particle mixer simple in construction, simple operation, when stirring
By stirring paddle, medical material is stirred, it is possible to make medicine pass from open-work, now by rotarily driving of ring rotation block
Stirring bar rotates, thus is stirred further by the medicine through open-work, such that it is able to be greatly improved stirring efficiency and also more
Easily being stirred by medicine, stability in use is strong and practicality good.The glipizide tablet of present invention screening is suitable for industrialization
Big production.
Accompanying drawing explanation
Fig. 1 is the structural representation of Particle mixer
Detailed description of the invention
The foregoing of the present invention is described in further detail by form more by the following examples, but should this not understood
Scope for the above-mentioned theme of the present invention is only limitted to Examples below, and all technology realized based on foregoing of the present invention all belong to
In the scope of the present invention.
Embodiment 1
Weigh glipizide 10g, hydroxypropyl methyl cellulose 30g, calcium carbonate 40g, ASPARTIC ACID 15g, sea
Sodium alginate 15g, calcium sulphate dihydrate 20g, guar gum 10g, polyvinylpolypyrrolidone 8g, magnesium stearate 1g.
Preparation technology: glipizide crude drug is placed in disintegrating apparatus pulverizing；Glipizide after pulverizing according to quantity is former
Material medicine is mixed homogeneously in Particle mixer with above-mentioned adjuvant, pelletizes according to a conventional method, and finished product packed to obtain by tabletting.
Above-mentioned Particle mixer, is shown in Fig. 1, including agitator 1, shaft 2 and that is arranged in described agitator 1
It is arranged on described agitator 1 stirring motor 3 being connected with described shaft 2, described shaft 2 is provided with and stirs
Mix oar 4, described stirring paddle 4 is provided with open-work 5, the inwall of described open-work 5 is provided with annular groove 6, described
It is provided with ring rotation block 7 in annular groove 6, is provided with in described stirring paddle 4 and driving that described annular groove 6 is connected
Dynamic chamber 8, is provided with micro-machine 9 in described driving chamber 8, is provided with driving fluted disc on the main shaft of described micro-machine 9
10, the outer ring surface of described ring rotation block 7 is provided with the teeth groove 11 mutually ratcheting with described driving fluted disc 10, described
Being uniformly provided with at least three stirring bar 12 on the inner ring surface of ring rotation block 7, described stirring bar is at the band of described micro-machine
Under Dong in described open-work Stirring.Medical material is stirred by stirring paddle when stirring, it is possible to make medical material from open-work
Passing, the stirring bar that rotarily drives now by ring rotation block rotates, thus is stirred further by the medical material through open-work,
Such that it is able to be greatly improved the efficiency of stirring and be easier to stir medical material.
Two sides of described stirring paddle 4 are horn-like setting and trumpet-shaped center is connected with open-work.Use loudspeaker
Shape, make stirring paddle agitation time, medical material can try one's best more than pass through in open-work.
Described shaft 2 is provided with upset motor 13, the main shaft of described upset motor 13 and described stirring paddle 4
End is connected, and drives stirring paddle to realize turning operation during described upset electric motor starting.Can also be as required by stirring paddle
Overturn, thus be greatly improved the efficiency of agitation.
Described stirring cylinder 1 is provided with the control knob 14 being connected with described micro-machine and described upset motor
The speed governing knob 15 being connected.Line for convenience in the present embodiment, can centrally disposed for hollow, so by shaft
After by wear from shaft centrally through, it can be configured line according to the technical experience of technical staff, and also needs
Bucket door to be arranged.
Comparative example 2
Weigh glipizide 5g, hydroxypropyl methyl cellulose 40g, calcium carbonate 30g, ASPARTIC ACID 20g, Sargassum
Acid sodium 10g, calcium sulphate dihydrate 25g, guar gum 5g, polyvinylpolypyrrolidone 10g, magnesium stearate 0.5g.
Preparation technology is ibid.
Comparative example 3
Weigh glipizide 15g, hydroxypropyl methyl cellulose 20g, calcium carbonate 50g, ASPARTIC ACID 10g, Sargassum
Acid sodium 20g, calcium sulphate dihydrate 15g, guar gum 15g, polyvinylpolypyrrolidone 5g, magnesium stearate 2.0g.
Preparation technology is ibid.
Comparative example 4
Weigh glipizide 10g, hydroxypropyl methyl cellulose 30g, calcium carbonate 40g, ASPARTIC ACID 15g, sea
Sodium alginate 15g, calcium sulphate dihydrate 20g, guar gum 10g, polyvinylpolypyrrolidone 8g, magnesium stearate 1g.
Using plain particles blender in preparation technology, other steps are ibid.
The release research of embodiment 5 glipizide tablet
Take the embodiment of the present invention 1 respectively, tablet prepared by comparative example 2-4, according to drug release determination method [version 5 in 2005
Chinese Pharmacopoeia (two) annex XD the first method], with 0.5% sodium dodecyl sulfate solution 1000mL as solvent, rotating speed is
50r/min, operates in accordance with the law, takes solution 10mL respectively at 2,4,6,8,10,12,14,16,18,20,22,24h, filters, and
Supplement above-mentioned solvent 10mL in time；Take subsequent filtrate, according to spectrophotography (version 5 Chinese Pharmacopoeia (two) annex IVA in 2005)
Trap is measured at 274nm wavelength；Another precision weighs through 105 degree of glipizide reference substances being dried 2h appropriate, adds
0.5% sodium dodecyl sulfate solution heating supersound process is dissolved and is quantitatively diluted in every 1mL the solution containing 10ug medicine,
It is measured in the same method trap, and calculates the burst size at different time respectively.Dissolution determination result such as table 1
Dissolution of sustained-release tablets measurement result prepared by each embodiment of table 1
| Sample source | 1h (%) | 3h (%) | 6h (%) | 9h (%) | 12h (%) | 24h (%) |
| Embodiment 1 | 24.5 | 51.8 | 73.2 | 84.3 | 95.1 | 101.4 |
| Comparative example 2 | 57.6 | 93.1 | 94.9 | 95.2 | 99.7 | 99.5 |
| Comparative example 3 | 63.8 | 90.4 | 96.2 | 102.6 | 97.5 | 97.9 |
| Comparative example 4 | 59.1 | 92.6 | 95.4 | 100.1 | 98.3 | 98.6 |
According to the result of the test of table 1, the glipizide tablet release of the embodiment of the present invention 1 preparation is steadily；Contrast is implemented
Example 2-3 is different due to supplementary material ratio, discharges too fast, and glipizide is used plain particles blender by comparative example 4
Mixing, owing in the granule of preparation, glipizide is not fully wrapped up by adjuvant, therefore discharges too fast.
Claims (7)
1. the glipizide tablet treating diabetes, it is characterised in that by tablet total weight amount percentages, by following component group
Become: glipizide 5-15 part, hydroxypropyl methyl cellulose 20-40 part, calcium carbonate 30-50 part, ASPARTIC ACID 10-20
Part, sodium alginate 10-20 part, calcium sulphate dihydrate 15-25 part, guar gum 5-15 part, polyvinylpolypyrrolidone 5-10 part, hard
Fatty acid magnesium 0.5-2.0 part.
2. treat the glipizide tablet of diabetes as claimed in claim 1, it is characterised in that the formula of glipizide tablet is as follows:
Glipizide 10g, hydroxypropyl methyl cellulose 30g, calcium carbonate 40g, ASPARTIC ACID 15g, sodium alginate 15g, two
H 2 O calcium sulphate 20g, guar gum 10g, polyvinylpolypyrrolidone 8g, magnesium stearate 1g.
3. treat the glipizide tablet of diabetes as claimed in claim 1, it is characterised in that preparation method comprises the following steps:
Take glipizide crude drug and be placed in disintegrating apparatus pulverizing；Glipizide crude drug and above-mentioned adjuvant after pulverizing according to quantity are at granule
Stirrer for mixing is uniform, pelletizes according to a conventional method, and finished product packed to obtain by tabletting.
4. treat the glipizide tablet of diabetes as claimed in claim 3, it is characterised in that Particle mixer in preparation method,
Including agitator, the shaft that is arranged in described agitator be arranged on described agitator and stirring that described shaft is connected
Mix motor, described shaft be provided with stirring paddle, it is characterised in that: on described stirring paddle, it is provided with open-work, at described open-work
Inwall be provided with annular groove, in described annular groove, be provided with ring rotation block, be provided with in described stirring paddle and described ring
The driving chamber that connected in star is connected, is provided with micro-machine at described driving intracavity, is provided with driving on the main shaft of described micro-machine
Fluted disc, is provided with the teeth groove mutually ratcheting with described driving fluted disc, at described ring rotation block on the outer ring surface of described ring rotation block
Inner ring surface on be uniformly provided with at least three stirring bar, described stirring bar under the drive of described micro-machine in described open-work inward turning
Turn stirring.
Treat the glipizide tablet of diabetes the most according to claim 4, it is characterised in that granule stirs evenly stirring paddle in device
Two sides be horn-like setting and trumpet-shaped center is connected with open-work.
Treat the glipizide tablet of diabetes the most according to claim 4, it is characterised in that granule stirs evenly shaft in device
Being provided with upset motor, the main shaft of described upset motor is connected with the end of described stirring paddle, carries during described upset electric motor starting
Dynamic stirring paddle realizes turning operation.
Treat the glipizide tablet of diabetes the most according to claim 4, it is characterised in that granule stirs evenly agitator in device
Body is provided with the speed governing knob that the control knob being connected with described micro-machine is connected with described upset motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610457314.3A CN105943514A (en) | 2016-06-22 | 2016-06-22 | Glipizide tablets for treating diabetes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610457314.3A CN105943514A (en) | 2016-06-22 | 2016-06-22 | Glipizide tablets for treating diabetes and preparation method thereof |
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| CN105943514A true CN105943514A (en) | 2016-09-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610457314.3A Pending CN105943514A (en) | 2016-06-22 | 2016-06-22 | Glipizide tablets for treating diabetes and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389765A (en) * | 2016-10-19 | 2017-02-15 | 南京康凯生物科技有限公司 | Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof |
| CN106421546A (en) * | 2016-10-14 | 2017-02-22 | 全椒先奇医药科技有限公司 | Traditional Chinese medicine composition for treating atrophic gastritis and preparation method thereof |
| CN106420642A (en) * | 2016-10-14 | 2017-02-22 | 全椒先奇医药科技有限公司 | Cefixime chewable tablet and preparation method thereof |
| CN106421464A (en) * | 2016-10-14 | 2017-02-22 | 南京康凯生物科技有限公司 | Traditional Chinese medicine composition with function of reducing blood lipid and blood glucose and preparation method thereof |
| CN106619546A (en) * | 2016-10-14 | 2017-05-10 | 全椒先奇医药科技有限公司 | Simvastatin tablets capable of lowering blood lipid and preparation method of simvastatin tablets |
| CN106619554A (en) * | 2016-10-12 | 2017-05-10 | 南京康凯生物科技有限公司 | Adenosine triphosphate disodium tablet and preparation method thereof |
| CN106619707A (en) * | 2016-10-12 | 2017-05-10 | 南京康凯生物科技有限公司 | Compound reserpine tablet for treating hypertension and preparation method thereof |
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| US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
| CN102824324A (en) * | 2012-09-02 | 2012-12-19 | 迪沙药业集团有限公司 | Glipizide sustained release tablets |
| CN203342694U (en) * | 2013-06-28 | 2013-12-18 | 普罗旺斯番茄制品（天津）有限公司 | Stirring mechanism of stirring tank |
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2016
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| CN102824324A (en) * | 2012-09-02 | 2012-12-19 | 迪沙药业集团有限公司 | Glipizide sustained release tablets |
| CN203342694U (en) * | 2013-06-28 | 2013-12-18 | 普罗旺斯番茄制品（天津）有限公司 | Stirring mechanism of stirring tank |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619554A (en) * | 2016-10-12 | 2017-05-10 | 南京康凯生物科技有限公司 | Adenosine triphosphate disodium tablet and preparation method thereof |
| CN106619707A (en) * | 2016-10-12 | 2017-05-10 | 南京康凯生物科技有限公司 | Compound reserpine tablet for treating hypertension and preparation method thereof |
| CN106421546A (en) * | 2016-10-14 | 2017-02-22 | 全椒先奇医药科技有限公司 | Traditional Chinese medicine composition for treating atrophic gastritis and preparation method thereof |
| CN106420642A (en) * | 2016-10-14 | 2017-02-22 | 全椒先奇医药科技有限公司 | Cefixime chewable tablet and preparation method thereof |
| CN106421464A (en) * | 2016-10-14 | 2017-02-22 | 南京康凯生物科技有限公司 | Traditional Chinese medicine composition with function of reducing blood lipid and blood glucose and preparation method thereof |
| CN106619546A (en) * | 2016-10-14 | 2017-05-10 | 全椒先奇医药科技有限公司 | Simvastatin tablets capable of lowering blood lipid and preparation method of simvastatin tablets |
| CN106389765A (en) * | 2016-10-19 | 2017-02-15 | 南京康凯生物科技有限公司 | Traditional Chinese medicine composition capable of dispelling effect of alcohol and preparation method thereof |
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Application publication date: 20160921 |