CN106074425A - A kind of hypoglycemic diabecron sustained-release tablet and preparation method thereof - Google Patents
A kind of hypoglycemic diabecron sustained-release tablet and preparation method thereof Download PDFInfo
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- CN106074425A CN106074425A CN201610465369.9A CN201610465369A CN106074425A CN 106074425 A CN106074425 A CN 106074425A CN 201610465369 A CN201610465369 A CN 201610465369A CN 106074425 A CN106074425 A CN 106074425A
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- parts
- hypoglycemic
- release tablet
- stirring
- diabecron sustained
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
- B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
- B01F27/11251—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis having holes in the surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/123—Maintenance of mixers using mechanical means using scrapers for cleaning mixers
Abstract
The present invention relates to a kind of hypoglycemic diabecron sustained-release tablet, belong to Western medicine preparation technical field, it is made up of element sheet and coating, it is characterized in that based on slow releasing tablet total weight percent, described plain sheet consists of the following composition: metformin hydrochloride 30 70 parts, D mannitol 10 30 parts, croscarmellose 10 30 parts, lubrication fluidizer 1 10 parts etc., use specific Particle mixer to mix, and the tablet slow release of the present invention is steady.
Description
Technical field
The invention belongs to Western medicine preparation technical field, particularly to a kind of hypoglycemic diabecron sustained-release tablet.
Background technology
Metformin hydrochloride is a kind of biguanides that can be administered orally and be used widely, and is that the current world is flourishing
Country still at the unique oral biguanides hyperglycemia medicine used, can improve the type-II diabetes patient tolerance to sugar, reduce
Basis and Post-prandial plasma glucose concentration, mechanism of action is different from other antidiabetic medicines.Metformin hydrochloride reduces glycogen
Generate, make small intestinal that the absorption of sugar to be reduced, by increasing periphery, picked-up and the utilization of sugar are improved the opposing of insulin.Just
Ordinary person and type-II diabetes patient do not produce hypoglycemic reaction, does not the most produce hyperinsulinemia.Use clinically at present
Metformin hydrochloride is conventional tablet and capsule etc., and common dose is 1.5g every day, takes in three times.Therefore, it is necessary to will take medicine
Time is regularly spaced, guarantee blood drug level maintaining treatment level, there is clothes for patients inconvenience, easily forgets clothes, misses,
The shortcomings such as blood concentration fluctuation is big.
Summary of the invention
In order to overcome the deficiencies in the prior art, adjuvant screening, process optimization and equipment are changed by the present invention by lot of experiments
Enter, it is provided that a kind of diabecron sustained-release tablet.This tablet slow release, gastrointestinal side-effect are little, and preparation technology is simple.
The object of the present invention is achieved like this:
A kind of hypoglycemic diabecron sustained-release tablet, is made up of, by slow releasing tablet total weight percent element sheet and coating
Meter, described plain sheet consists of the following composition: metformin hydrochloride 30-70 part, D-mannital 10-30 part, cross-links methylol
Cellulose 10-30 part, lubricates fluidizer 1-10 part, guar gum 5-25 part and sweeting agent 1-20 part；Slow release pressed by described coating
Sheet gross weight is that 100 parts of meters consist of the following composition: methylcellulose 1-3 part, sodium carboxymethyl cellulose 0.5-3 part, propylene glycol
0.5-5 part, polyvinylpyrrolidone 1-4 part, No. IV acrylic resin 0.5-1.5 part, lubrication fluidizer 0.5-2 part.
Described hypoglycemic diabecron sustained-release tablet, lubrication fluidizer selected from sodium stearyl fumarate, magnesium stearate, two
One or more in silicon oxide, Pulvis Talci.
Described hypoglycemic diabecron sustained-release tablet, sweeting agent is selected from lactose, sucrose, glucose, xylitol, Pyrusussuriensis
One or more in alcohol, mannitol, steviosin, saccharin sodium, aspartame.
Described hypoglycemic diabecron sustained-release tablet, based on slow releasing tablet total weight percent, described plain sheet by with
Lower one-tenth is grouped into: metformin hydrochloride 50 parts, D-mannital 20 parts, croscarmellose 20 parts, magnesium stearate 5 parts,
Guar gum 15 parts and lactose 10 parts.
Described hypoglycemic diabecron sustained-release tablet, described coating by slow releasing tablet gross weight be based on 100 parts by with
Lower one-tenth is grouped into: methylcellulose 2 parts, sodium carboxymethyl cellulose 2 parts, propylene glycol 3 parts, polyvinylpyrrolidone 3 parts, No. IV third
Olefin(e) acid resin 1 part, Pulvis Talci 1 part.
Described hypoglycemic diabecron sustained-release tablet, preparation method comprises the following steps: the hydrochloric acid after sieving
Metformin, D-mannital, croscarmellose, guar gum are placed in Particle mixer and are sufficiently mixed, and prepare soft
Material；(3) above-mentioned soft material being added lubrication fluidizer after drying, obtain mixed powder, mixed powder all adds Multidirectional motion mixing
Machine, uses swinging lozenge machine tabletting, prepares element sheet；(4) preparation of coating solution: mix after being sieved by lubrication fluidizer, adds
Methylcellulose, sodium carboxymethyl cellulose, propylene glycol, polyvinylpyrrolidone, No. IV acrylic resin, after stirring by hand
Use colloid mill circular grinding again, prepare coating solution；(5) being joined in atresia coating pan by element sheet, regulate intake, element sheet is pre-
After heat, add above-mentioned coating solution and be coated；(6) by prepared slow releasing tablet packaging.
Described hypoglycemic diabecron sustained-release tablet, Particle mixer in preparation method, including mixing drum, stirring
Lid, actuating device and mixing component, described mixing cover threadeds with described mixing drum, and described mixing component includes stirring axostylus axostyle
Be connected to the stirring paddle that described stirring axostylus axostyle is connected, described actuating device is connected with described stirring axostylus axostyle, and its feature exists
In: on described stirring paddle, it is provided with circular hole, the sidewall of described circular hole is provided with regulating tank, in described regulating tank, be provided with regulation
Plate, is provided with the little cylinder of regulation, at the inwall of described adjustable plate Yu described regulating tank between described adjustable plate and described regulating tank
Between be provided with sealing ring, described adjustable plate under the effect of the little cylinder of described regulation in circular hole the mobile diameter realized circular hole
Regulation, is provided with bar-shaped trough on the side of described stirring paddle, is provided with screw mandrel in described bar-shaped trough, be provided with in described stirring paddle
The clockwise and anticlockwise motor being connected with described screw mandrel, is provided with scraper plate in described bar-shaped trough, and described scraper plate is set by movable block activity
Put on described screw mandrel.
Described hypoglycemic diabecron sustained-release tablet, the opening of bar-shaped trough described in Particle mixer in preparation method
Place is provided with concertina type catch, and described concertina type catch is connected between the sidewall of bar-shaped trough and scraper plate.
Described hypoglycemic diabecron sustained-release tablet, in preparation method concertina type catch described in Particle mixer with
It is provided with seal block between described bar-shaped trough.
Described hypoglycemic diabecron sustained-release tablet, in preparation method, scraper plate described in Particle mixer is thin slice
Shape plate body.
Compared with prior art, the present invention relates to hypoglycemic diabecron sustained-release tablet and there is the most useful technology
Effect:
(1) release is steadily.(2) preparation technology is simple, and granule blender simple in construction, simple operation are provided with circular hole, can
To facilitate medicine to pass through from circular hole when stirring, from preventing medicine to be attached to stirring paddle side, and it is provided with scraper plate, can be by
The medicine being in stirring paddle side scrapes so that it is pass through in circular hole, can improve the uniformity of medicine stirring to a certain extent, can
Effectively solve conventional art stirs uneven technical deficiency, substantially increase the efficiency of stirring.The hydrochloric acid of present invention screening
Metformin Extended-release Tablets is suitable for industrialized great production.
Accompanying drawing explanation
Fig. 1 is the structural representation of Particle mixer
Detailed description of the invention
The foregoing of the present invention is described in further detail by form more by the following examples, but should this not managed
The scope for the above-mentioned theme of the present invention that solves is only limitted to Examples below, and all technology realized based on foregoing of the present invention all belong to
In the scope of the present invention.
Embodiment 1
Weigh supplementary material in proportion: metformin hydrochloride 50 parts, D-mannital 20 parts, croscarmellose 20
Part, magnesium stearate 5 parts, guar gum 15 parts and lactose 10 parts, methylcellulose 2 parts, sodium carboxymethyl cellulose 2 parts, propylene glycol 3
Part, 3 parts, No. IV acrylic resin of polyvinylpyrrolidone 1 part, Pulvis Talci 1 part.
Preparation technology:
Metformin hydrochloride after sieving, D-mannital, croscarmellose, guar gum, lactose are placed in
Particle mixer is sufficiently mixed, prepares soft material；(3) above-mentioned soft material is added magnesium stearate after drying, obtain mixed powder, mixed
Close powder and all add Mixers with Multi-direction Movement, use swinging lozenge machine tabletting, prepare element sheet；(4) preparation of coating solution: will be sliding
Stone powder mixes after sieving, and adds methylcellulose, sodium carboxymethyl cellulose, propylene glycol, polyvinylpyrrolidone, No. IV acrylic acid
Resin, uses colloid mill circular grinding after stirring by hand again, prepares coating solution；(5) element sheet is joined in atresia coating pan,
Regulate intake, after element sheet preheating, add above-mentioned coating solution and be coated；(6) by prepared slow releasing tablet packaging.
Particle mixer, including mixing drum 1, mixing cover 2, actuating device 3 and mixing component 4, described mixing cover 2 is with described
Mixing drum 1 is threaded, and described mixing component 4 includes stirring axostylus axostyle 41 and being connected to the stirring that described stirring axostylus axostyle 41 is connected
Oar 42, described actuating device 3 is connected with described stirring axostylus axostyle 41, is provided with circular hole 5, at described circular hole on described stirring paddle 42
The sidewall of 5 is provided with regulating tank 6, is provided with adjustable plate 7, in described regulating tank 6 between described adjustable plate and described regulating tank
It is provided with the little cylinder 8 of regulation, by regulating the position of little cylinder control and regulation plate, thus the regulation of circular hole can be realized, in stirring
During beginning regulating circular hole to maximum rating, now medical material can as much as possible be mixed by circular hole, when stirring when stirring
Mix fast at the end of, circular hole is regulated to minimum state, now major part medical material can be stirred oar side block and with rotate from
And the amount that medical material is stirred can be improved, between described adjustable plate 7 and the inwall of described regulating tank 6, it is provided with sealing ring 9, has close
Seal can prevent medical material from entering in regulating tank, and described adjustable plate 7 is mobile real in circular hole under the effect of the little cylinder of described regulation 8
The now diameter adjustment to circular hole 5, is provided with bar-shaped trough 10 on the side of described stirring paddle 42, is provided with silk in described bar-shaped trough 10
Bar 11, is provided with the clockwise and anticlockwise motor 12 being connected with described screw mandrel 11 in described stirring paddle 42, is provided with in described bar-shaped trough
Scraper plate 13, described scraper plate 13 is movably arranged on described screw mandrel 11 by movable block 14.Rotating can also be passed through when stirring
Motor controls scraper plate and moves the medical material that will be attached to stirring paddle side and scraped, thus can prevent because being attached to stirring paddle side
The deficiency of impact mixing.
Opening part at described bar-shaped trough 10 is provided with concertina type catch 15, and described concertina type catch is connected to the side of bar-shaped trough
Between wall and scraper plate.When scraper plate moves in bar-shaped trough, the concertina type catch of one end is compressed by band, the concertina type gear of the other end
Sheet stretches, thus can prevent medical material from entering in bar-shaped trough, it is ensured that the stability that screw mandrel runs.
It is provided with seal block 16 between described concertina type catch and described bar-shaped trough.
Described scraper plate is flake plate body.
Comparative example 2
Weigh supplementary material in proportion: metformin hydrochloride 30 parts, D-mannital 30 parts, croscarmellose 10
Part, magnesium stearate 10 parts, guar gum 5 parts and lactose 20 parts；Methylcellulose 1 part, sodium carboxymethyl cellulose 3 parts, propylene glycol
0.5 part, 4 parts, No. IV acrylic resin of polyvinylpyrrolidone 0.5 part, Pulvis Talci 2 parts.
Preparation technology is ibid.
Comparative example 3
Weigh supplementary material in proportion: metformin hydrochloride 70 parts, D-mannital 10 parts, croscarmellose 30
Part, magnesium stearate 1 part, guar gum 25 parts and lactose 1 part；Methylcellulose 3 parts, sodium carboxymethyl cellulose 0.5 part, propylene glycol
5 parts, 1 part, No. IV acrylic resin of polyvinylpyrrolidone 1.5 parts, Pulvis Talci 0.5 part.
Preparation technology is ibid.
Comparative example 4
Weigh supplementary material in proportion: metformin hydrochloride 50 parts, D-mannital 20 parts, croscarmellose 20
Part, magnesium stearate 5 parts, guar gum 15 parts and lactose 10 parts, methylcellulose 2 parts, sodium carboxymethyl cellulose 2 parts, propylene glycol 3
Part, 3 parts, No. IV acrylic resin of polyvinylpyrrolidone 1 part, Pulvis Talci 1 part.
Using plain particles blender in preparation technology, other steps are ibid.
The release research of embodiment 5 diabecron sustained-release tablet
Dissolution test method: the tablet that respectively prepared by Example 1 and comparative example 2-4, according to drug release determination method
(Chinese Pharmacopoeia two annex Ⅹ D the first methods of version in 2010), Chinese Pharmacopoeia version annex in 2010,75 turns/min of blue laws, to remove sky
The fresh water 1000ml of gas is this product release solvent.Ultraviolet spectrophotometry is selected to utilize absorption coefficient method to measure at 233nm
The release of diabecron sustained-release tablet.
Dissolution of sustained-release tablets measurement result prepared by each embodiment of table 1
| Sample source | 1h (%) | 3h (%) | 6h (%) | 9h (%) | 12h (%) | 24h (%) |
| Embodiment 1 | 22.8 | 56.3 | 72.8 | 84.5 | 94.7 | 101.1 |
| Comparative example 2 | 34.7 | 62.8 | 91.3 | 99.4 | 100.5 | 98.4 |
| Comparative example 3 | 68.3 | 97.1 | 99.6 | 102.1 | 99.7 | 99.5 |
| Comparative example 4 | 45.8 | 56.9 | 99.4 | 98.4 | 99.0 | 100.1 |
According to the result of the test of table 1, the diabecron sustained-release tablet release of the embodiment of the present invention 1 preparation is steadily；
Comparative example 2 is different due to supplementary material or packaging material ratio with 3, discharges too fast, and comparative example 4 is due to hydrochloride
Biguanide uses the mixing of plain particles blender, owing in the granule of preparation, metformin hydrochloride is not fully wrapped up by adjuvant, therefore releases
Let slip fast.
Claims (10)
1. a hypoglycemic diabecron sustained-release tablet, is made up of element sheet and coating, it is characterised in that by slow releasing tablet gross weight
Amount percentages, described plain sheet consists of the following composition: metformin hydrochloride 30-70 part, D-mannital 10-30 part, hands over
Connection hydroxymethyl cellulose 10-30 part, lubricates fluidizer 1-10 part, guar gum 5-25 part and sweeting agent 1-20 part；Described bag
Clothing is to consist of the following composition based on 100 parts by slow releasing tablet gross weight: methylcellulose 1-3 part, sodium carboxymethyl cellulose 0.5-3
Part, propylene glycol 0.5-5 part, polyvinylpyrrolidone 1-4 part, No. IV acrylic resin 0.5-1.5 part, lubrication fluidizer 0.5-2
Part.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 1, it is characterised in that lubrication fluidizer is selected from tristearin
One or more in fumaric acid sodium, magnesium stearate, silicon dioxide, Pulvis Talci.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 1, it is characterised in that sweeting agent is selected from lactose, sugarcane
One or more in sugar, glucose, xylitol, sorbitol, mannitol, steviosin, saccharin sodium, aspartame.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 1, it is characterised in that by slow releasing tablet gross weight percentage
Than meter, described plain sheet consists of the following composition: metformin hydrochloride 50 parts, D-mannital 20 parts, cross-links hydroxylmethyl cellulose
Element 20 parts, magnesium stearate 5 parts, guar gum 15 parts and lactose 10 parts.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 1, it is characterised in that slow releasing tablet pressed by described coating
Gross weight is that 100 parts of meters consist of the following composition: methylcellulose 2 parts, sodium carboxymethyl cellulose 2 parts, propylene glycol 3 parts, poly-second
3 parts, No. IV acrylic resin of alkene pyrrolidone 1 part, Pulvis Talci 1 part.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 1, it is characterised in that preparation method includes following
Step: the metformin hydrochloride after sieving, D-mannital, croscarmellose, guar gum are placed in granule stirring
Machine is sufficiently mixed, prepares soft material；(3) above-mentioned soft material being added lubrication fluidizer after drying, obtain mixed powder, mixed powder is complete
Portion adds Mixers with Multi-direction Movement, uses swinging lozenge machine tabletting, prepares element sheet；(4) preparation of coating solution: fluidizer will be lubricated
Agent mixes after sieving, and adds methylcellulose, sodium carboxymethyl cellulose, propylene glycol, polyvinylpyrrolidone, No. IV acrylic acid tree
Fat, uses colloid mill circular grinding after stirring by hand again, prepares coating solution；(5) element sheet is joined in atresia coating pan, adjust
Save intake, after element sheet preheating, added above-mentioned coating solution and be coated；(6) by prepared slow releasing tablet packaging.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 6, it is characterised in that granule stirring in preparation method
Machine, including mixing drum, mixing cover, actuating device and mixing component, described mixing cover is threadeded with described mixing drum, described in stir
Mix assembly to include stirring axostylus axostyle and being connected to the stirring paddle that described stirring axostylus axostyle is connected, described actuating device and described shaft
Bar is connected, it is characterised in that: on described stirring paddle, it is provided with circular hole, the sidewall of described circular hole is provided with regulating tank, in institute
It is provided with adjustable plate in stating regulating tank, between described adjustable plate and described regulating tank, is provided with the little cylinder of regulation, at described adjustable plate
And being provided with sealing ring between the inwall of described regulating tank, described adjustable plate moves under the effect of the little cylinder of described regulation in circular hole
The dynamic diameter adjustment realized circular hole, is provided with bar-shaped trough on the side of described stirring paddle, is provided with screw mandrel in described bar-shaped trough,
In described stirring paddle, be provided with the clockwise and anticlockwise motor being connected with described screw mandrel, in described bar-shaped trough, be provided with scraper plate, described in scrape
Plate is movably arranged on described screw mandrel by movable block.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 7, it is characterised in that granule stirring in preparation method
The opening part of bar-shaped trough described in machine is provided with concertina type catch, described concertina type catch be connected to the sidewall of bar-shaped trough and scraper plate it
Between.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 7, it is characterised in that granule stirring in preparation method
Concertina type catch described in machine and be provided with seal block between described bar-shaped trough.
Hypoglycemic diabecron sustained-release tablet the most as claimed in claim 7, it is characterised in that granule stirring in preparation method
Scraper plate described in machine is flake plate body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610465369.9A CN106074425A (en) | 2016-06-23 | 2016-06-23 | A kind of hypoglycemic diabecron sustained-release tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610465369.9A CN106074425A (en) | 2016-06-23 | 2016-06-23 | A kind of hypoglycemic diabecron sustained-release tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106074425A true CN106074425A (en) | 2016-11-09 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610465369.9A Withdrawn CN106074425A (en) | 2016-06-23 | 2016-06-23 | A kind of hypoglycemic diabecron sustained-release tablet and preparation method thereof |
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| CN (1) | CN106074425A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731505A (en) * | 2019-02-26 | 2019-05-10 | 岳超然 | A kind of mixing device stirred evenly for cream production |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007021072A1 (en) * | 2005-08-18 | 2007-02-22 | Hanall Pharmaceutical Co., Ltd. | Metformin tablet with sustained release and method for preparing the same |
| CN101579325A (en) * | 2009-06-16 | 2009-11-18 | 重庆康刻尔制药有限公司 | Metformin hydrochloride controlled-release tablet and preparation method thereof |
| CN203342694U (en) * | 2013-06-28 | 2013-12-18 | 普罗旺斯番茄制品（天津）有限公司 | Stirring mechanism of stirring tank |
-
2016
- 2016-06-23 CN CN201610465369.9A patent/CN106074425A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007021072A1 (en) * | 2005-08-18 | 2007-02-22 | Hanall Pharmaceutical Co., Ltd. | Metformin tablet with sustained release and method for preparing the same |
| CN101579325A (en) * | 2009-06-16 | 2009-11-18 | 重庆康刻尔制药有限公司 | Metformin hydrochloride controlled-release tablet and preparation method thereof |
| CN203342694U (en) * | 2013-06-28 | 2013-12-18 | 普罗旺斯番茄制品（天津）有限公司 | Stirring mechanism of stirring tank |
Non-Patent Citations (3)
| Title |
|---|
| 方亮: "《药用高分子材料学》", 31 August 2015, 中国医药科技出版社 * |
| 王春，等: "盐酸二甲双胍片的生产工艺改进", 《山东医药工业》 * |
| 胡容峰: "《工业药剂学》", 31 August 2010, 北京：中国中医药出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731505A (en) * | 2019-02-26 | 2019-05-10 | 岳超然 | A kind of mixing device stirred evenly for cream production |
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