CN106074426A - A kind of Theo-Dur treating bronchial asthma and preparation method thereof - Google Patents
A kind of Theo-Dur treating bronchial asthma and preparation method thereof Download PDFInfo
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- CN106074426A CN106074426A CN201610465370.1A CN201610465370A CN106074426A CN 106074426 A CN106074426 A CN 106074426A CN 201610465370 A CN201610465370 A CN 201610465370A CN 106074426 A CN106074426 A CN 106074426A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
- B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
- B01F27/11251—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis having holes in the surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/123—Maintenance of mixers using mechanical means using scrapers for cleaning mixers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of Theo-Dur treating bronchial asthma, belong to Western medicine preparation technical field, it is made up of element sheet and coating, it is characterised in that based on slow releasing tablet total weight percent, described plain sheet consists of the following composition: theophylline 30 70 parts, L alanine 10 30 parts, polyvinylpyrrolidone 10 30 parts, lubricates fluidizer 1 10 parts, alginic acid 5 15 parts etc., using specific Particle mixer to mix, the tablet slow release of the present invention is steady.
Description
Technical field
The invention belongs to Western medicine preparation technical field, particularly to a kind of Theo-Dur treating bronchial asthma.
Background technology
Theo-Dur, indication is alleviated for being applicable to bronchial asthma, asthmatic bronchitis, obstructive emphysema etc.
Wheezing symptoms；Can also be used for the asthma that cardiac pulmonary edema causes.The theophylline sheet release instability used clinically at present, because of
This, it is necessary to will be regularly spaced medicine time, guarantee blood drug level maintaining treatment level, there is clothes for patients with not
Just, easily forget clothes, miss, the shortcomings such as blood concentration fluctuation is big.
Summary of the invention
In order to overcome the deficiencies in the prior art, adjuvant screening, process optimization and equipment are changed by the present invention by lot of experiments
Enter, it is provided that a kind of Theo-Dur.This tablet slow release, gastrointestinal side-effect are little, and preparation technology is simple.
The object of the present invention is achieved like this:
A kind of Theo-Dur treating bronchial asthma, is made up of, by slow releasing tablet total weight percent element sheet and coating
Meter, described plain sheet consists of the following composition: theophylline 30-70 part, ALANINE 10-30 part, polyvinylpyrrolidone 10-30
Part, lubricate fluidizer 1-10 part, alginic acid 5-15 part and sweeting agent 1-20 part；Described coating is 100 by slow releasing tablet gross weight
Part meter consists of the following composition: sodium carboxymethyl cellulose 0.5-3 part, and propylene glycol 0.5-5 part lubricates fluidizer 0.5-2 part.
The Theo-Dur of described treatment bronchial asthma, lubrication fluidizer is selected from magnesium stearate, silicon dioxide, Pulvis Talci
In one or more.
The Theo-Dur of described treatment bronchial asthma, sweeting agent is selected from lactose, sucrose, glucose, xylitol, Pyrusussuriensis
One or more in alcohol, mannitol, steviosin, saccharin sodium, aspartame.
The Theo-Dur of described treatment bronchial asthma, sustained-release theophylline slice prescription based on slow releasing tablet total weight percent,
Described plain sheet consists of the following composition: theophylline 50 parts, ALANINE 20 parts, polyvinylpyrrolidone 20 parts, magnesium stearate 5
Part, alginic acid 8 parts and lactose 10 parts.
The Theo-Dur of described treatment bronchial asthma, sustained-release theophylline slice prescription based on slow releasing tablet total weight percent,
Described coat weight formula proportion is as follows: sodium carboxymethyl cellulose 2 parts, propylene glycol 2 parts, Pulvis Talci 1 part.
The Theo-Dur of described treatment bronchial asthma, preparation method comprises the following steps: that (1) is by part polyethylene
Ketopyrrolidine is dissolved in ethanol solution, is prepared as alcoholic solution；(2) theophylline after sieving, remaining polyvinylpyrrolidone,
ALANINE, alginic acid, sweeting agent are placed in Particle mixer and are sufficiently mixed, and the alcohol adding above-mentioned polyvinylpyrrolidone is molten
Liquid, is sufficiently mixed, and prepares soft material；(3) above-mentioned soft material being added lubrication fluidizer after drying, obtain mixed powder, mixed powder is complete
Portion adds Mixers with Multi-direction Movement, uses swinging lozenge machine tabletting, prepares element sheet；(4) preparation of coating solution: fluidizer will be lubricated
Agent mixes after sieving, and adds in the ethanol solution containing sodium carboxymethyl cellulose and propylene glycol, uses colloid again after stirring by hand
Mill circular grinding, prepares coating solution；(5) element sheet is joined in atresia coating pan, regulate intake, after element sheet preheating, add
Enter above-mentioned coating solution to be coated；(6) by prepared slow releasing tablet packaging.
The Theo-Dur of described treatment bronchial asthma, Particle mixer in preparation method, including mixing drum, stirring
Lid, actuating device and mixing component, described mixing cover threadeds with described mixing drum, and described mixing component includes stirring axostylus axostyle
Be connected to the stirring paddle that described stirring axostylus axostyle is connected, described actuating device is connected with described stirring axostylus axostyle, and its feature exists
In: on described stirring paddle, it is provided with circular hole, the sidewall of described circular hole is provided with regulating tank, in described regulating tank, be provided with regulation
Plate, is provided with the little cylinder of regulation, at the inwall of described adjustable plate Yu described regulating tank between described adjustable plate and described regulating tank
Between be provided with sealing ring, described adjustable plate under the effect of the little cylinder of described regulation in circular hole the mobile diameter realized circular hole
Regulation, is provided with bar-shaped trough on the side of described stirring paddle, is provided with screw mandrel in described bar-shaped trough, be provided with in described stirring paddle
The clockwise and anticlockwise motor being connected with described screw mandrel, is provided with scraper plate in described bar-shaped trough, and described scraper plate is set by movable block activity
Put on described screw mandrel.
The Theo-Dur of described treatment bronchial asthma, the opening of bar-shaped trough described in Particle mixer in preparation method
Place is provided with concertina type catch, and described concertina type catch is connected between the sidewall of bar-shaped trough and scraper plate.
The Theo-Dur of described treatment bronchial asthma, in preparation method concertina type catch described in Particle mixer with
It is provided with seal block between described bar-shaped trough.
The Theo-Dur of described treatment bronchial asthma, in preparation method, scraper plate described in Particle mixer is thin slice
Shape plate body.
Compared with prior art, the Theo-Dur that the present invention relates to has a most useful technique effect:
(1) release is steadily.(2) preparation technology is simple, and granule blender simple in construction, simple operation are provided with circular hole, can
To facilitate medicine to pass through from circular hole when stirring, from preventing medicine to be attached to stirring paddle side, and it is provided with scraper plate, can be by
The medicine being in stirring paddle side scrapes so that it is pass through in circular hole, can improve the uniformity of medicine stirring to a certain extent, can
Effectively solve conventional art stirs uneven technical deficiency, substantially increase the efficiency of stirring.The theophylline of present invention screening
Slow releasing tablet is suitable for industrialized great production.
Accompanying drawing explanation
Fig. 1 is the structural representation of Particle mixer
Detailed description of the invention
The foregoing of the present invention is described in further detail by form more by the following examples, but should this not managed
The scope for the above-mentioned theme of the present invention that solves is only limitted to Examples below, and all technology realized based on foregoing of the present invention all belong to
In the scope of the present invention.
Embodiment 1
Weighing following supplementary material weight in proportion, based on slow releasing tablet total weight percent, described plain sheet is by following component
Composition: theophylline 50 parts, ALANINE 20 parts, polyvinylpyrrolidone 20 parts, magnesium stearate 5 parts, alginic acid 8 parts and lactose 10
Part.Described coat weight formula proportion is as follows: sodium carboxymethyl cellulose 2 parts, propylene glycol 2 parts, Pulvis Talci 1 part.
Preparation technology:
(1) polyvinylpyrrolidone is dissolved in ethanol solution, is prepared as alcoholic solution；(2) theophylline after sieving, surplus
Under polyvinylpyrrolidone, ALANINE, alginic acid, lactose be placed in Particle mixer and be sufficiently mixed, add above-mentioned poly-second
The alcoholic solution of alkene pyrrolidone, is sufficiently mixed, and prepares soft material；(3) above-mentioned soft material is added after drying lubrication fluidizer stearic
Acid magnesium, obtains mixed powder, and mixed powder all adds Mixers with Multi-direction Movement, uses swinging lozenge machine tabletting, prepares element sheet；
(4) preparation of coating solution: mix after being sieved by Pulvis Talci, adds in the ethanol solution containing sodium carboxymethyl cellulose and propylene glycol,
Use colloid mill circular grinding again after stirring by hand, prepare coating solution；(5) element sheet is joined in atresia coating pan, regulation
Good intake, after element sheet preheating, adds above-mentioned coating solution and is coated；(6) by prepared slow releasing tablet packaging.
Seeing Fig. 1, Particle mixer, including mixing drum 1, mixing cover 2, actuating device 3 and mixing component 4, described mixing cover 2
Threadeding with described mixing drum 1, described mixing component 4 includes that stirring axostylus axostyle 41 is connected with being connected to described stirring axostylus axostyle 41
Stirring paddle 42, described actuating device 3 is connected with described stirring axostylus axostyle 41, is provided with circular hole 5, in institute on described stirring paddle 42
The sidewall stating circular hole 5 is provided with regulating tank 6, is provided with adjustable plate 7 in described regulating tank 6, in described adjustable plate and described regulation
It is provided with the little cylinder 8 of regulation between groove, by regulating the position of little cylinder control and regulation plate, thus the regulation of circular hole can be realized,
Regulating circular hole to maximum rating when stirring starts, now medical material can as much as possible be mixed by circular hole when stirring
Close, at the end of stirring is fast, circular hole regulated to minimum state, now major part medical material can be stirred oar side block and with
Rotate such that it is able to improve the amount that medical material is stirred, between described adjustable plate 7 and the inwall of described regulating tank 6, be provided with sealing ring
9, have sealing ring can prevent medical material from entering in regulating tank, described adjustable plate 7 under the effect of the little cylinder of described regulation 8 in circular hole
The mobile diameter adjustment realized circular hole 5, is provided with bar-shaped trough 10, on the side of described stirring paddle 42 in described bar-shaped trough 10
It is provided with screw mandrel 11, in described stirring paddle 42, is provided with the clockwise and anticlockwise motor 12 being connected with described screw mandrel 11, at described bar-shaped trough
Inside being provided with scraper plate 13, described scraper plate 13 is movably arranged on described screw mandrel 11 by movable block 14.Can also pass through when stirring
Clockwise and anticlockwise motor control scraper plate moves the medical material that will be attached to stirring paddle side and is scraped, thus can prevent because being attached to stirring paddle
Side and affect the deficiency of mixing.
Opening part at described bar-shaped trough 10 is provided with concertina type catch 15, and described concertina type catch is connected to the side of bar-shaped trough
Between wall and scraper plate.When scraper plate moves in bar-shaped trough, the concertina type catch of one end is compressed by band, the concertina type gear of the other end
Sheet stretches, thus can prevent medical material from entering in bar-shaped trough, it is ensured that the stability that screw mandrel runs.
It is provided with seal block 16 between described concertina type catch and described bar-shaped trough.
Described scraper plate is flake plate body.
Comparative example 2
Weighing following supplementary material weight in proportion, based on slow releasing tablet total weight percent, described plain sheet is by following component
Composition: theophylline 30 parts, ALANINE 30 parts, polyvinylpyrrolidone 10 parts, magnesium stearate 10 parts, alginic acid 5 parts and lactose 20
Part；Described coating is to consist of the following composition based on 100 parts by slow releasing tablet gross weight: sodium carboxymethyl cellulose 0.5 part, propylene glycol
5 parts, Pulvis Talci 0.5 part.
Preparation technology is ibid.
Comparative example 3
Weighing following supplementary material weight in proportion, based on slow releasing tablet total weight percent, described plain sheet is by following component
Composition: theophylline 70 parts, ALANINE 10 parts, PVPK30 part, magnesium stearate 1 part, alginic acid 15 parts and lactose 1
Part；Described coating is to consist of the following composition based on 100 parts by slow releasing tablet gross weight: sodium carboxymethyl cellulose 3 parts, propylene glycol
0.5 part, Pulvis Talci 2 parts.
Preparation technology is ibid.
Comparative example 4
Weighing following supplementary material weight in proportion, based on slow releasing tablet total weight percent, described plain sheet is by following component
Composition: theophylline 50 parts, ALANINE 20 parts, polyvinylpyrrolidone 20 parts, magnesium stearate 5 parts, alginic acid 8 parts and lactose 10
Part.Described coat weight formula proportion is as follows: sodium carboxymethyl cellulose 2 parts, propylene glycol 2 parts, Pulvis Talci 1 part.
Using plain particles blender in preparation technology, other steps are ibid.
The release research of embodiment 5 Theo-Dur
Dissolution test method: take the embodiment of the present invention 1 respectively, comparative example 2,3,4 contrasts, surveys according to release
Determine method (Chinese Pharmacopoeia two annex Ⅹ D the first methods of version in 2010), Chinese Pharmacopoeia version annex in 2010,75 turns/min of blue laws, with
The fresh water 1000ml removing air is this product release solvent.Ultraviolet spectrophotometry is selected to utilize absorption coefficient method at 233nm
Measure the release of Theo-Dur.
Dissolution of sustained-release tablets measurement result prepared by each embodiment of table 1
| Sample source | 1h (%) | 3h (%) | 6h (%) | 9h (%) | 12h (%) | 24h (%) |
| Embodiment 1 | 25.3 | 57.1 | 73.2 | 86.4 | 93.2 | 102.5 |
| Comparative example 2 | 57.4 | 94.5 | 96.8 | 96.3 | 94.2 | 97.9 |
| Comparative example 3 | 68.6 | 97.9 | 99.4 | 102.2 | 99.8 | 99.3 |
| Comparative example 4 | 57.9 | 54.3 | 68.9 | 98.2 | 98.5 | 99.4 |
According to the result of the test of table 1, the Theo-Dur release of the embodiment of the present invention 1 preparation is steadily；Contrast is implemented
Example 2-3 is different from the ratio of adjuvant due to principal agent, and theophylline is used plain particles blender to mix by comparative example 4, due to system
In standby granule, theophylline is not fully wrapped up by adjuvant, therefore discharges too fast.
Claims (10)
1. treat a Theo-Dur for bronchial asthma, be made up of element sheet and coating, it is characterised in that by slow releasing tablet gross weight
Amount percentages, described plain sheet consists of the following composition: theophylline 30-70 part, ALANINE 10-30 part, polyvinylpyrrolidine
Ketone 10-30 part, lubricates fluidizer 1-10 part, alginic acid 5-15 part and sweeting agent 1-20 part；Slow releasing tablet gross weight pressed by described coating
Amount is that 100 parts of meters consist of the following composition: sodium carboxymethyl cellulose 0.5-3 part, propylene glycol 0.5-5 part, lubricates fluidizer 0.5-2
Part.
A kind of Theo-Dur treating bronchial asthma, it is characterised in that lubrication fluidizer choosing
One or more in magnesium stearate, silicon dioxide, Pulvis Talci.
3. treat the Theo-Dur of bronchial asthma as claimed in claim 1, it is characterised in that sweeting agent is selected from lactose, sugarcane
One or more in sugar, glucose, xylitol, sorbitol, mannitol, steviosin, saccharin sodium, aspartame.
4. treat the Theo-Dur of bronchial asthma as claimed in claim 1, it is characterised in that preparation method includes following
Step: part polyethylene ketopyrrolidine is dissolved in ethanol solution by (1), is prepared as alcoholic solution；Theophylline after (2) sieving,
Remaining polyvinylpyrrolidone, ALANINE, alginic acid, sweeting agent are placed in Particle mixer and are sufficiently mixed, and add above-mentioned
The alcoholic solution of polyvinylpyrrolidone, is sufficiently mixed, and prepares soft material；(3) above-mentioned soft material is added lubrication fluidizer after drying,
Obtaining mixed powder, mixed powder all adds Mixers with Multi-direction Movement, uses swinging lozenge machine tabletting, prepares element sheet；(4) coating
The preparation of liquid: mix after being sieved by lubrication fluidizer, adds in the ethanol solution containing sodium carboxymethyl cellulose and propylene glycol, manual
Use colloid mill circular grinding after stirring again, prepare coating solution；(5) element sheet is joined in atresia coating pan, regulate into
Air quantity, after element sheet preheating, adds above-mentioned coating solution and is coated；(6) by prepared slow releasing tablet packaging.
5. treat the Theo-Dur of bronchial asthma as claimed in claim 1, it is characterised in that sustained-release theophylline slice prescription is by slow
Releasing sheet total weight percent meter, described plain sheet consists of the following composition: theophylline 50 parts, ALANINE 20 parts, polyvinyl pyrrole
Alkanone 20 parts, magnesium stearate 5 parts, alginic acid 8 parts and lactose 10 parts.
6. treat the Theo-Dur of bronchial asthma as claimed in claim 1, it is characterised in that sustained-release theophylline slice prescription is by slow
Releasing sheet total weight percent meter, described coat weight formula proportion is as follows: sodium carboxymethyl cellulose 2 parts, propylene glycol 2 parts, sliding
Stone powder 1 part.
7. treat the Theo-Dur of bronchial asthma as claimed in claim 4, it is characterised in that granule stirring in preparation method
Machine, including mixing drum, mixing cover, actuating device and mixing component, described mixing cover is threadeded with described mixing drum, described in stir
Mix assembly to include stirring axostylus axostyle and being connected to the stirring paddle that described stirring axostylus axostyle is connected, described actuating device and described shaft
Bar is connected, it is characterised in that: on described stirring paddle, it is provided with circular hole, the sidewall of described circular hole is provided with regulating tank, in institute
It is provided with adjustable plate in stating regulating tank, between described adjustable plate and described regulating tank, is provided with the little cylinder of regulation, at described adjustable plate
And being provided with sealing ring between the inwall of described regulating tank, described adjustable plate moves under the effect of the little cylinder of described regulation in circular hole
The dynamic diameter adjustment realized circular hole, is provided with bar-shaped trough on the side of described stirring paddle, is provided with screw mandrel in described bar-shaped trough,
In described stirring paddle, be provided with the clockwise and anticlockwise motor being connected with described screw mandrel, in described bar-shaped trough, be provided with scraper plate, described in scrape
Plate is movably arranged on described screw mandrel by movable block.
8. treat the Theo-Dur of bronchial asthma as claimed in claim 4, it is characterised in that granule stirring in preparation method
The opening part of bar-shaped trough described in machine is provided with concertina type catch, described concertina type catch be connected to the sidewall of bar-shaped trough and scraper plate it
Between.
9. treat the Theo-Dur of bronchial asthma as claimed in claim 4, it is characterised in that granule stirring in preparation method
Concertina type catch described in machine and be provided with seal block between described bar-shaped trough.
10. treat the Theo-Dur of bronchial asthma as claimed in claim 4, it is characterised in that granule stirring in preparation method
Scraper plate described in machine is flake plate body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610465370.1A CN106074426A (en) | 2016-06-23 | 2016-06-23 | A kind of Theo-Dur treating bronchial asthma and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610465370.1A CN106074426A (en) | 2016-06-23 | 2016-06-23 | A kind of Theo-Dur treating bronchial asthma and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106074426A true CN106074426A (en) | 2016-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610465370.1A Withdrawn CN106074426A (en) | 2016-06-23 | 2016-06-23 | A kind of Theo-Dur treating bronchial asthma and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211894A (en) * | 2017-12-25 | 2018-06-29 | 何玉静 | A kind of municipal wastewater processing adds mixing arrangement with liquid |
| CN116966157A (en) * | 2023-09-22 | 2023-10-31 | 山东则正医药技术有限公司 | Theophylline sustained release tablet and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0283316A (en) * | 1988-09-20 | 1990-03-23 | Shin Etsu Chem Co Ltd | Sustained release tablet |
| CN102988323A (en) * | 2012-10-08 | 2013-03-27 | 李正梅 | Preparation method of aniracetam sustained-release tablet |
| CN103239419A (en) * | 2013-05-15 | 2013-08-14 | 瑞阳制药有限公司 | Method for preparing theophylline sustained release |
| CN203342694U (en) * | 2013-06-28 | 2013-12-18 | 普罗旺斯番茄制品（天津）有限公司 | Stirring mechanism of stirring tank |
-
2016
- 2016-06-23 CN CN201610465370.1A patent/CN106074426A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0283316A (en) * | 1988-09-20 | 1990-03-23 | Shin Etsu Chem Co Ltd | Sustained release tablet |
| CN102988323A (en) * | 2012-10-08 | 2013-03-27 | 李正梅 | Preparation method of aniracetam sustained-release tablet |
| CN103239419A (en) * | 2013-05-15 | 2013-08-14 | 瑞阳制药有限公司 | Method for preparing theophylline sustained release |
| CN203342694U (en) * | 2013-06-28 | 2013-12-18 | 普罗旺斯番茄制品（天津）有限公司 | Stirring mechanism of stirring tank |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211894A (en) * | 2017-12-25 | 2018-06-29 | 何玉静 | A kind of municipal wastewater processing adds mixing arrangement with liquid |
| CN116966157A (en) * | 2023-09-22 | 2023-10-31 | 山东则正医药技术有限公司 | Theophylline sustained release tablet and preparation method thereof |
| CN116966157B (en) * | 2023-09-22 | 2024-02-09 | 山东则正医药技术有限公司 | Theophylline sustained release tablet and preparation method thereof |
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