CN106421546A - Traditional Chinese medicine composition for treating atrophic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating atrophic gastritis and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
- B01F27/232—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes
- B01F27/2322—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes with parallel axes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/85—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with two or more stirrers on separate shafts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Abstract
The invention relates to a traditional Chinese medicine composition for treating atrophic gastritis. The traditional Chinese medicine composition is prepared from, by weight, 30-50 parts of herba dracocephali tangutici, 20-30 parts of Hupeh Bauhinia root, 10-20 parts of Anaphalis sinica Hance form.pterocaula(Franch.et Savat.)Ling, 10-20 parts of Chamaerhodos erecta, 10-30 parts of malt, 10-30 parts of poria cocos, 10-30 parts of Chinese yam, 5-15 parts of semen coicis and 5-15 parts of licorice root. A specific granule stirrer is adopted for mixing. The traditional Chinese medicine composition is good in content uniformity and has the effect of treating atrophic gastritis.
Description
Technical field
The invention belongs to traditional Chinese medicine health care product technical field, treat atrophic gastritis Chinese medicine composition particularly to one kind.
Background technology
Atrophic gastritis clinical manifestation is only Abdeminal pain, belch, stomach receive the indigestion symptom such as go down, sometimes because in stomach
The factor is destroyed, and vitamin B12 malabsorption can cause anaemia.Endoscopy and biopsy are the unique hands making a definite diagnosis atrophic gastritis
Section.Gastroscope Diagnosis should include the degree of diseased region, atrophy degree, intestinal metaplasia and atypical hyperplasia.Naked eyes line-of-sight observation atrophy
Property gastritis mucous membrane more than in pale or greyish white, pleat attenuates or flat.Mucous membrane can show atrophic gastritis red and white, serious
The mucous membrane of patient is dispersed in white patch.Submucosal blood vessel appears feature for atrophic gastritis it is seen that red netted petty action
Arteries and veins or capillary, serious atrophic gastritis is it is seen that there is epithelial hyperplasia to form fine particle or compared with major tubercle.Also have viscous
Film is rotten to the corn, bleeding.Mucosa Biopsy pathology be mainly the different degrees of atrophy of body of gland, disappearance, instead gland metaplasia or
Intestinal gland metaplasia, interstitial inflammation infiltration is notable.Atrophic gastritis is located at the body of gland of stomach lining because of reasons such as inflammatory infiltrations, and body of gland withers
Contracting or disappearance.Its incidence of disease of atrophic gastritis with the increase at age and showed increased.Be mainly shown as upper abdomen glutted, uncomfortable or
Pain, after the meal substantially, simultaneously with other indigestion symptoms such as belch, sour regurgitation, Nausea and vomiting, poor appetite etc..City at present
Treatment by Chinese herbs atrophic gastritis product variety on field is various, but is mostly all made with medicine, large side effects or poor taste, content
The uniformity is bad, usually produces some side effects when clinically patient takes.
Content of the invention
In order to overcome the deficiencies in the prior art, the present invention is changed to auxiliary material screening, process optimization and equipment by lot of experiments
Enter, there is provided one kind treats atrophic gastritis Chinese medicine composition, uniformity of dosage units is good, preparation process is simple.
The object of the present invention is achieved like this:
One kind treats atrophic gastritis Chinese medicine composition, and it is prepared from by following raw materials in part by weight proportioning:Herba Dracocephali Tangutici
30-50 part, hupeh bauhinia root 20-30 part, Chinese pearleverlasting herb 10-20 part, erect chamaerhodos herb 10-20 part, malt 10-30 part, Poria cocos 10-30 part,
Chinese yam 10-30 part, coix seed 5-15 part, Radix Glycyrrhizae 5-15 part.
Described treatment atrophic gastritis Chinese medicine composition, it is prepared from by following raw materials in part by weight proportioning:Herba Dracocephali Tangutici
40 parts, 25 parts of hupeh bauhinia root, 15 parts of Chinese pearleverlasting herb, 15 parts of erect chamaerhodos herb, 20 parts of malt, 20 parts of Poria cocos, 20 parts of Chinese yam, coix seed 10
Part, 10 parts of Radix Glycyrrhizae.
Described treatment atrophic gastritis Chinese medicine composition, formulation is granule, tablet, capsule.
Described treatment atrophic gastritis Chinese medicine composition, preparation method step is:Take kansu crazyweed herb, capitate knotweed herb, cochinchina passionflower herb,
Cassia seed, waxgourd peel, Chinese yam, the root of kudzu vine, FI puerariae, trifoliate orange medicinal material merge, and add water to cook twice, and collecting decoction is concentrated into 65 DEG C
When relative density be 1.10-1.20, plus ethanol makes the percent by volume of alcohol content reach 65-85%, stirring, standing, filters, filtrate
When being evaporated to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, obtains concentrate, concentrate is spray-dried, add
Auxiliary material, mixes in Particle mixer, pelletizes according to a conventional method, makes capsule, tablet, granule.
Described treatment atrophic gastritis Chinese medicine composition, in preparation method, decocting condition is:Add water as medicinal material weight for the first time
The 8-12 times amount of amount, decocts 1-2h, the 6-10 times amount adding water for the second time as medicinal material weight, decocts 1-2h.
Described treatment atrophic gastritis Chinese medicine composition, in preparation method, spray drying condition is:EAT is 100-
120 DEG C, leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-0.4 MPa, and spray velocity is 5-
10ml/s.
Described treatment atrophic gastritis Chinese medicine composition, preparation method comprises the following steps:Take above-mentioned raw materials medicine and auxiliary
Material is placed in disintegrating apparatus and pulverizes;Particle mixer mixes, pelletizes according to a conventional method, compressing tablet, pack to obtain finished product.
Described treatment atrophic gastritis Chinese medicine composition, Particle mixer in preparation method, including base, it is arranged on described
Stirring cylinder on base, is provided with stirring motor, the main shaft of described stirring motor and described stirring cylinder in described base
Bottom wall central is connected, and is provided with stirring mast on the diapire in described mixing drum body, perpendicular in the side wall of described stirring cylinder
To being uniformly provided with least two cavitys, it is provided with L-type material casting plate in described cavity, the corner of described L-type material casting plate passes through rotation
Rotating shaft is connected in cavity and the outboard end of described L-type material casting plate stretches in described mixing drum body, is provided with throwing in described cavity
Material motor, is provided with the main shaft of described material casting motor and compresses eccentric wheel, the medial extremity of described L-type material casting plate and institute
It is provided with stress spring, the described wheel side compressing eccentric wheel is pressed on L-type material casting plate medial extremity and cavity between the side wall stating cavity
Between the wall of side, described base is additionally provided with support rod, regulation vertical slot is provided with described support rod, in described regulation vertical slot
It is provided with elevator, be provided with lift cylinder between described elevator and described regulation vertical slot, in described elevator, be provided with rotation
Motor, is provided with column spinner on the main shaft of described electric rotating machine, described column spinner stretch into when described elevator declines described in stir
Mix in cylinder and described column spinner and stirring mast stagger setting.
Described treatment atrophic gastritis Chinese medicine composition, is provided with sealing gasket at the opening of described cavity, described rotary shaft bag
It is rolled in described sealing gasket.
Described treatment atrophic gastritis Chinese medicine composition, described column spinner is provided with stirring palpus, in described stirring cylinder
Roof is provided with charging aperture and feeding detection mouth.
Application in preparation treatment atrophic gastritis Chinese medicine for the described treatment atrophic gastritis Chinese medicine composition.
Herba Dracocephali Tangutici is Labiatae dragonhead Herba Dracocephali Tangutici Dracocephalum tanguticum Maxim., with
All herbal medicine.7~August excavates whole herb with root, clean segment, dries.Soothing the liver with stomach.For gastritis, gastric ulcer, hepatitis, liver is swollen
Greatly.
Hupeh bauhinia root is pulse family bauhinia bauhinia hupehana Craib Bauhinia hupehana Craib, is used as medicine with root.Wild
Health product autumn uproots;Cultivation product after cultivation 3,4 years, uproot, and dries by autumn.Clearing heat and promoting diuresis, swelling and pain relieving.For preventing and treating dysentery
Disease, testiclar gall, eczema of scrotum.
Chinese pearleverlasting herb is the herb of feverfew Chinese pearleverlasting herb.
Erect chamaerhodos herb is the herb of rosaceous plant erect chamaerhodos herb.
Compared with prior art, FUFANG LIXUEPING PIAN according to the present invention has technique effect beneficial as follows:
(1) uniformity of dosage units is good.(2) preparation process is simple, structure is simple, is provided with L-type material casting plate, and it passes through when using
Compressing eccentric wheel cooperation stress spring can make L-type material casting plate rotate centered on rotary shaft, thus by mixing drum interior part medicine
Thing throws to the center of mixing drum, and is additionally provided with column spinner, by the reverse rotation of column spinner and mixing drum, can will be in L
The bottom medicine agitation of type material casting plate, the medicine decline such that it is able to make L-type material casting back is stirred by column spinner, thus significantly
Improve stirring efficiency, and be not easy occur stirring dead angle, solve conventional art medicine agitating device stirring have dead angle and
The low technical deficiency of stirring efficiency, stability in use is good and strong applicability.(3) Herba Dracocephali Tangutici of the present invention, hupeh bauhinia root, wing stem are fragrant
Blue or green, erect chamaerhodos herb and stomach soothing the liver for monarch drug in a prescription, malt, Poria cocos, Chinese yam, coix seed clearing heat and promoting diuresis are ministerial drug, and Radix Glycyrrhizae is adjuvant, jointly
There is treatment atrophic gastritis effect.
Brief description
Fig. 1 is the structural representation of Particle mixer
Specific embodiment
Form is described in further detail to the above of the present invention again by the following examples, but should not manage this
Solve the scope for the above-mentioned theme of the present invention and be only limitted to Examples below, all belonged to based on the technology that the above of the present invention is realized
In the scope of the present invention.
1st, combine specific embodiment, the present invention is further described as follows:
According to the form below, listed weight proportion weighs needed raw material of the present invention, unit:g
Herba Dracocephali Tangutici | Hupeh bauhinia root | Chinese pearleverlasting herb | Erect chamaerhodos herb | Malt | Poria cocos | Chinese yam | Coix seed | Radix Glycyrrhizae | |
Embodiment 1 | 30 | 30 | 10 | 20 | 10 | 30 | 10 | 15 | 5 |
Embodiment 2 | 40 | 25 | 15 | 15 | 20 | 20 | 20 | 10 | 10 |
Embodiment 3 | 50 | 20 | 20 | 10 | 30 | 10 | 30 | 5 | 15 |
2nd, taking upper table Central Plains material proportioning as a example, comprise the following steps:
Embodiment 1:Weigh medicinal material by upper table and mix, add water to cook twice, 8 times adding water for the first time as medicinal material weight
Amount, decocts 1h, 6 times amount adding water for the second time as medicinal material weight, decocts 1h, collecting decoction, filtration, filtrate is concentrated into relative density
1.10 (65 DEG C), plus ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stirring, stands 24 hours, filtration, filtrate reclaims second
Alcohol is simultaneously concentrated into the medicinal extract of relative density 1.20 (65 DEG C), and spray-dried (condition is 100 DEG C for EAT, leaving air temp
For 80 DEG C, temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), it is ground into dry extract, add
Auxiliary material, mixes in Particle mixer, pelletizes according to a conventional method, makes granule.
Above-mentioned Particle mixer, is shown in Fig. 1, including including base 1, is arranged on the stirring cylinder 2 on described base 1, in institute
State and in base 1, be provided with stirring motor 3, the main shaft of described stirring motor 3 is connected with the bottom wall central of described stirring cylinder 2,
Diapire in described stirring cylinder 2 is provided with stirring mast 4, is vertically uniformly provided with least in the side wall of described stirring cylinder 2
Two cavitys 5, are provided with L-type material casting plate 6 in described cavity 5, and the corner of described L-type material casting plate 6 is connected to by rotary shaft 7
In cavity 5 and the outboard end of described L-type material casting plate 6 stretches in described stirring cylinder 2, it is provided with material casting in described cavity 5 and drives
Motor 8, is provided with the main shaft of described material casting motor 8 and compresses eccentric wheel 9, the medial extremity of described L-type material casting plate 6 with described
Be provided with stress spring 10 between the side wall of cavity 5, the described wheel side compressing eccentric wheel 9 be pressed on L-type material casting plate 6 medial extremity with recessed
Between the side wall of chamber 5, when using, the wheel side activity compressing eccentric wheel is pressed on the end of L-type material casting plate, so that L-type material casting
The end of plate is rotated centered on rotary shaft and stretches stress spring makes it store power, when rotating to the concave edge compressing eccentric wheel, L
The end of type material casting plate resets under the pulling of stress spring, so that medicinal material is thrown to and stirred by the plate body movement being in mixing drum
Mix the center of cylinder, described base 1 is additionally provided with support rod 11, regulation vertical slot 12 is provided with described support rod 11, described
Adjust in vertical slot 12 and be provided with elevator 13, between described elevator 13 and described regulation vertical slot 12, be provided with lift cylinder 14,
It is provided with electric rotating machine 15 in described elevator 13, column spinner 16, described column spinner are provided with the main shaft of described electric rotating machine 15
16 stretch in described mixing drum 2 when described elevator 13 declines and described column spinner 16 and stirring mast 4 stagger setting.In order to
Facilitate column spinner to enter mixing drum, the top cover of mixing drum can be opened after loading column spinner, then top cover is covered.
It is provided with sealing gasket 17 at the opening of described cavity 5, described rotary shaft is wrapped in described sealing gasket.
Described column spinner is provided with stirring palpus 18, is provided with charging aperture 19 and feeding detection on the roof of described stirring cylinder
Mouth 20.Using stirring palpus, because it is flexible material, so not interfering with the normal material casting operation of L-type material casting plate.
Embodiment 2:Weigh medicinal material by upper table and mix, add water to cook twice, 10 times adding water for the first time as medicinal material weight
Amount, decocts 1.5h, 8 times amount adding water for the second time as medicinal material weight, decocts 1.5h, collecting decoction, filtration, filtrate is concentrated into relatively
Density 1.15 (65 DEG C), plus ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stands 24 hours, filtration, filtrate is returned
Receive ethanol and be concentrated into the medicinal extract of relative density 1.25 (65 DEG C), spray-dried (condition is 120 DEG C for EAT, air-out
Temperature is 90 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.3 MPa, and spray velocity is 7.5/s.), it is ground into dry extract,
Add auxiliary material, mix in Particle mixer, pelletize according to a conventional method, make tablet.
Particle mixer is ibid.
Embodiment 3:Weigh medicinal material by upper table and mix, add water to cook twice, 10 times adding water for the first time as medicinal material weight
Amount, decocts 1.5h, 8 times amount adding water for the second time as medicinal material weight, decocts 1.5h, collecting decoction, filtration, filtrate is concentrated into relatively
Density 1.15 (65 DEG C), plus ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stands 24 hours, filtration, filtrate is returned
Receive ethanol and be concentrated into the medicinal extract of relative density 1.25 (65 DEG C), spray-dried (condition is 120 DEG C for EAT, air-out
Temperature is 90 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 7.5/s.), it is ground into dry extract,
Add auxiliary material, mix in Particle mixer, pelletize according to a conventional method, make capsule.
Particle mixer is ibid.
Comparative example 4:Make tablet with embodiment 2, using general Particle mixer.
3rd, uniformity of dosage units experiment
Content and content uniformity determination all by Chinese Pharmacopoeia two method operations of version in 2010, measures in Tablets
The content of diosgenin.It is reference substance from diosgenin, using AAS, perchloric acid develops the color, and surveys at 410nm
Determine absorbance, calculate total saponin content in the present invention.Ten tablets of Example 2 and comparative example 4 carry out Chinese yam respectively
The assay of sapogenin, finds that the Determination of Diosgenin in embodiment 2 is 0.14-0.16%, the potato in comparative example 4
Chinese yam sapogenin content is 0.03-0.25%, illustrates that embodiment 2 makes tablet content good evenness.
4th, the impact pharmacodynamic study to animal used as test
Experimental agents:Preparation method preparation by above-described embodiment 1.
Dosage:Then based on rat body weight, low dosage, middle dosage and high dose are respectively 2.5g crude drug amount/kg, 5g life
Dose/kg and 10g crude drug amount/kg.
Animal used as test:SD cleaning grade rat 60, male, body weight 180~210g, Shanghai Si Laike Experimental Animal Center carries
For.
Experiment reagent:Wei-Mei-Su tablet, Hebei is surrounded by sea pharmaceutcal corporation, Ltd, lot number 20110611;Sodium salicylate, Jiangsu is forever magnificent
Fine chemicals Co., Ltd, lot number 090709;95% medicinal alcohol, Nanjing Ning Shi chemical reagent Co., Ltd, lot number
20071128;Ammoniacal liquor, Chengdu Ke Long chemical reagent factory, lot number 20080622;Motilin, gastrin radioimmunological kit, Beijing
Fu Rui bio-engineering corporation.
Experimentation:60 rats are divided into 6 groups, respectively at random:Blank group, model group, Wei Mei Su Pian group, the present invention are little
Dosage group, middle dose group of the present invention, present invention heavy dose group, every group of l0 only, modeling except blank group is normal raise in addition to, other 5 groups
Using 2% sodium salicylate and 30% alcohol mixed solution, daily set time gavage, 1h fasting for solids and liquids, 10mL/ before and after gavage
kg;Rat freely drinks 0.05% ammoniacal liquor;Cooperation irregular diet method, often take food 2d, fasting 1d.Modeling randomly draws two before terminating
Only make gastric mucosa pathological histology inspection, confirm to occur stomach lining body of gland atrophy, intestines and atypical hyperplasia etc., stop modeling medicine
Thing, enters treatment stage.Modeling amounts to 17 weeks.Treatment amounts to 4 weeks.After end, Rat Fast 24h, 1.5% amobarbital abdominal cavity
Injecting anesthetic, cuts off the otch of an about 2.5cm, carefully lifts stomach in xiphoid-process lower edge hunter's line, ties with duodenum in pylorus
Conjunction portion is ligatured with suture, avoids blood vessel.Send back in cage after sewing-up cut.After 3h, then ligature orifice of the stomach, cut off esophagus lower end respectively
And duodenum near-end, extract full stomach, wash away surface blood stains, blotted with filter paper, put in culture dish and cut off gastral cavity along greater curvature, receive
Collection gastric juice, in centrifuge tube, is centrifuged 20min, Aspirate supernatant with 3000rpm, carries out gastric analysis, and wheat spy's capillary tube method surveys stomach
Protease, result is as follows:
The present invention is to pepsin influence research (X ± SD)
Note:Compare with model group, * P<0.05;**P<0.01
Experiment conclusion:The present invention can improve pepsin activity in atrophic gastritis rat model gastric juice, shows to withering
Contracting gastritis has certain therapeutic action.
Claims (10)
1. one kind treats atrophic gastritis Chinese medicine composition it is characterised in that it is prepared from by following raw materials in part by weight proportioning:
Herba Dracocephali Tangutici 30-50 part, hupeh bauhinia root 20-30 part, Chinese pearleverlasting herb 10-20 part, erect chamaerhodos herb 10-20 part, malt 10-30 part, Poria cocos
10-30 part, Chinese yam 10-30 part, coix seed 5-15 part, Radix Glycyrrhizae 5-15 part.
2. treatment atrophic gastritis Chinese medicine composition as claimed in claim 1 is it is characterised in that it is joined by following raw materials in part by weight
Ratio is prepared from:40 parts of Herba Dracocephali Tangutici, 25 parts of hupeh bauhinia root, 15 parts of Chinese pearleverlasting herb, 15 parts of erect chamaerhodos herb, 20 parts of malt, 20 parts of Poria cocos,
20 parts of Chinese yam, 10 parts of coix seed, 10 parts of Radix Glycyrrhizae.
3. treatment atrophic gastritis Chinese medicine composition as claimed in claim 1 is it is characterised in that formulation is granule, tablet, glue
Wafer.
4. treatment atrophic gastritis Chinese medicine composition as claimed in claim 1 is it is characterised in that preparation method step is:Take Gansu
Whin, capitate knotweed herb, cochinchina passionflower herb, cassia seed, waxgourd peel, Chinese yam, the root of kudzu vine, FI puerariae, trifoliate orange medicinal material merge, and add water to cook twice,
Collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, plus ethanol makes the percent by volume of alcohol content reach 65-85%,
Stirring, standing, filter, filtrate reduced in volume to relative density when 65 DEG C is 1.20-1.30 and reclaims ethanol, obtains concentrate, will
Concentrate is spray-dried, and adds auxiliary material, mixes, pelletize according to a conventional method, make capsule, piece in Particle mixer
Agent, granule.
5. treatment atrophic gastritis Chinese medicine composition as claimed in claim 4 is it is characterised in that decocting condition in preparation method
For:The 8-12 times amount adding water as medicinal material weight for the first time, decocts 1-2h, the 6-10 times amount adding water for the second time as medicinal material weight, decocts
Boil 1-2h.
6. treatment atrophic gastritis Chinese medicine composition as claimed in claim 4 is it is characterised in that be spray-dried in preparation method
Condition is:EAT is 100-120 DEG C, and leaving air temp is 80-90 DEG C, and temperature of charge is 70-90 DEG C, and atomizing pressure is 0.2-
0.4 MPa, spray velocity is 5-10ml/s.3. treatment atrophic gastritis Chinese medicine composition as claimed in claim 1, its feature exists
Comprise the following steps in preparation method:Above-mentioned raw materials medicine and auxiliary material is taken to be placed in disintegrating apparatus and pulverize;In Particle mixer
Mix, pelletize according to a conventional method, compressing tablet, pack to obtain finished product.
7. treatment atrophic gastritis Chinese medicine composition as claimed in claim 4 is it is characterised in that Particle mixer in preparation method,
Including base, it is arranged on the stirring cylinder on described base, be provided with stirring motor, the master of described stirring motor in described base
Axle is connected with the bottom wall central of described stirring cylinder, is provided with stirring mast, described on the diapire in described mixing drum body
Vertically it is uniformly provided with least two cavitys in the side wall of stirring cylinder, is provided with L-type material casting plate in described cavity, described L-type is thrown
The corner of flitch is connected in cavity by rotary shaft and the outboard end of described L-type material casting plate stretches in described mixing drum body,
It is provided with material casting motor in described cavity, the main shaft of described material casting motor is provided with and compresses eccentric wheel, described L-type
It is provided with stress spring, the described wheel side compressing eccentric wheel is pressed on L-type between the side wall of the medial extremity of material casting plate and described cavity
Between material casting plate medial extremity and cavity side walls, described base is additionally provided with support rod, regulation is provided with described support rod perpendicular
Groove, is provided with elevator in described regulation vertical slot, is provided with lift cylinder, in institute between described elevator and described regulation vertical slot
State and in elevator, be provided with electric rotating machine, the main shaft of described electric rotating machine is provided with column spinner, described column spinner is in described lifting
Setting that block stretches in described mixing drum when declining and described column spinner and stirring mast stagger.
8. treat atrophic gastritis Chinese medicine composition according to claim 4 it is characterised in that setting at the opening of described cavity
There is sealing gasket, described rotary shaft is wrapped in described sealing gasket.
9. treat atrophic gastritis Chinese medicine composition according to claim 4 it is characterised in that described column spinner is provided with and stirs
Mix palpus, the roof of described stirring cylinder is provided with charging aperture and feeding detection mouth.
10. application in treatment atrophic gastritis Chinese medicine for the treatment atrophic gastritis Chinese medicine composition as claimed in claim 1.
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CN102940846A (en) * | 2012-12-08 | 2013-02-27 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating atrophic gastritis as welln as preparation method and application of composition |
CN105943514A (en) * | 2016-06-22 | 2016-09-21 | 南京华宽信息咨询中心 | Glipizide tablets for treating diabetes and preparation method thereof |
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CN102940846A (en) * | 2012-12-08 | 2013-02-27 | 南京正宽医药科技有限公司 | Traditional Chinese medicine composition for treating atrophic gastritis as welln as preparation method and application of composition |
CN105943514A (en) * | 2016-06-22 | 2016-09-21 | 南京华宽信息咨询中心 | Glipizide tablets for treating diabetes and preparation method thereof |
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