CN1369289A

CN1369289A - Chinese medicine for treating cardiovascular and cerebrovascular diseases and its preparing process

Info

Publication number: CN1369289A
Application number: CN 01129112
Authority: CN
Inventors: 曹柱
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-11-23
Filing date: 2001-11-23
Publication date: 2002-09-18
Anticipated expiration: 2021-11-23
Also published as: CN1199664C

Abstract

A Chinese medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart diseases, stenocardia, senile dementia, etc. is prepared from 3 Chinese-medicinal materials: red sage root, gingko leaf and astragalus root through extracting, proportioning and dispensing. Its advantages are simple preparing process, and full use of active components.

Description

Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease and preparation method thereof

The present invention is a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, belongs to technical field of medicaments.

Cardiovascular and cerebrovascular disease is a kind of frequently-occurring disease, commonly encountered diseases, existing Drug therapy generally is to take independent Chinese medicine product, such as: the Radix Salviae Miltiorrhizae goods, Semen Ginkgo goods etc., because these medicines are generally the single preparation, so there is not the usefulness of Comprehensive Treatment, therapeutic effect is undesirable, can only alleviate suffering from symptom, there is not special obvious treatment effect, Radix Salviae Miltiorrhizae mainly contains for the pharmacological action of cardiovascular and cerebrovascular vessel: coronary blood flow increasing, accelerate the periphery microcirculation blood flow, and increase the open number of capillary bed, improve heart merit and dwindle infarction size, antithrombotic, effects such as anti-cardiac-cerebral ischemia and accent blood fat; The Radix Astragali mainly contains for the pharmacological action of cardiovascular and cerebrovascular vessel: increase coronary flow and myocardial oxygen consumption, improve cardiac function, strengthen the anti-virus ability of cardiac muscle, the metabolism of anti-anoxia ability and enhancing myocardial cell, arteriosclerosis, blood vessel dilating and hypotensive effect have protective effect for cerebral ischemia associated with hydrocephalus, blood brain barrier, the local wachte measurer of brain; Folium Ginkgo extract mainly contains for the pharmacological action of cardiovascular and cerebrovascular vessel: expansion of cerebral vascular, cerebral blood flow increasing amount, reduce vascular resistance, also reduce cardiac muscular tension-time index, improve hemorheology status, blood circulation promoting, suppress thrombosis, alleviate cerebral hypoxia ischemia and cerebral edema, medium etc. affects the nerves; The medicines that utilize this three flavor two in Chinese medicine flavor to produce the in the prior art use of having gone on the market, such as: heart Yuan capsule, NAOLUOTONG JIAONANG etc.; But through the retrieval in State Administration of Traditional Chinese Medicine China Chinese medicine documentation retrieval centre, " not finding by Folium Ginkgo, Radix Salviae Miltiorrhizae, the Radix Astragali three flavor medicines is that prescription is declared new drug or declared the bibliographical information of Chinese medicine health care product patent ".

The objective of the invention is to: a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof is provided, this medicine is that Radix Salviae Miltiorrhizae, Folium Ginkgo, this three active ingredient of distinguishing the flavor of Chinese medicine of the Radix Astragali are become preparation according to certain prescription, ratio making after extracting, medicine combines this three flavors Chinese medicine separately for the function of people body-centered, cerebrovascular disease therapy, effect with blood circulation promoting and blood stasis dispelling, invigorating qi and dredging collateral can be treated cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris and alzheimer disease, cerebral thrombosis; The formulation method that is provided is simple, can not destroy active ingredient in the medical material, can utilize the medical material active ingredient fully, saves production cost.

The present invention constitutes like this: the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease is that 800-1400 is restrained Radix Salviae Miltiorrhizae, and 600-1200 restrains the Radix Astragali, extracts wherein active ingredient respectively after the processing of 600-1200 gram Folium Ginkgo process, is made into 1000 preparations; Say accurately: with 1200 gram Radix Salviae Miltiorrhizaes, the 1000 gram Radixs Astragali, 1000 gram Folium Ginkgos extract wherein active ingredient respectively after processing, be made into 1000 preparations; Be to improve therapeutic effect, can also be outside Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ginkgo extract, simultaneously or add a certain amount of Radix Ginseng, Radix Notoginseng respectively; The manufacture method of the Chinese medicine preparation of this treatment cardiovascular and cerebrovascular disease, be to use the alcohol heating reflux of 95-100% to extract the Radix Salviae Miltiorrhizae of aforementioned proportion, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get existing alcohol extraction----the resin method technology of Folium Ginkgo utilization and extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the Radix Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, technical finesse obtains extractum routinely, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously is made powder after the oven dry, incapsulate; The present invention also can utilize prior art to extract tanshinone from Radix Salviae Miltiorrhizae, extracts astragaloside from the Radix Astragali, extract ginkgetin and bilobalide from Folium Ginkgo, it is mixed into paste, be made into soft capsule or drop pill, make medicine preparation more perfect like this, improve its effective percentage, satisfy different patient demands.

Compared with prior art: medicine of the present invention has the function of blood circulation promoting and blood stasis dispelling, invigorating qi and dredging collateral, can treat cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris and alzheimer disease, cerebral thrombosis; The formulation method that is provided is simple, can not destroy active ingredient in the medical material, can utilize the medical material active ingredient fully, saves production cost; In product, make full use of prescription medical material effect separately, can coronary blood flow increasing, accelerate the periphery microcirculation blood flow, increase the open number of capillary bed, improve heart merit and dwindle infarction size, antithrombotic, anti-cardiac-cerebral ischemia and transfer blood fat; Increase myocardial oxygen consumption; improve cardiac function; strengthen the anti-virus ability of cardiac muscle, the metabolism of anti-anoxia ability and enhancing myocardial cell, arteriosclerosis, blood vessel dilating; for cerebral ischemia associated with hydrocephalus, blood brain barrier, the local wachte measurer of brain protective effect is arranged; the cerebral blood flow increasing amount reduces vascular resistance, also reduces cardiac muscular tension-time index; improve hemorheology status, blood circulation promoting, suppress thrombosis, alleviate cerebral hypoxia ischemia and cerebral edema, medium etc. affects the nerves.

Embodiments of the invention 1: the alcohol heating reflux of 1200 gram Radix Salviae Miltiorrhizaes with 95-100% extracted, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get 1000 gram Folium Ginkgo dryings, pulverize, use the alcohol reflux of 50-70% then, utilize prior art to extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the 1000 gram Radixs Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, technical finesse obtains extractum routinely, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously, make powder after the oven dry, in 1000 capsules of packing into.

Embodiments of the invention 2: the alcohol heating reflux of 800 gram Radix Salviae Miltiorrhizaes with 95-100% extracted, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get existing alcohol extraction----the resin method technology of 1200 gram Folium Ginkgo utilizations and extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the 600 gram Radixs Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, carry out precipitate with ethanol, obtain extractum, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously is made powder after the oven dry, incapsulate 1000.

Embodiments of the invention 3: get 1200 gram Radix Salviae Miltiorrhizaes, the 1000 gram Radixs Astragali, 1000 gram Folium Ginkgos utilize prior art to extract from Radix Salviae Miltiorrhizae, isolate tanshinone, extract astragalus polysaccharides and astragaloside from the Radix Astragali, extract ginkgetin and bilobalide from Folium Ginkgos, it is mixed into paste, is made into soft capsule or drop pill.

Embodiments of the invention 4: in embodiment 1,2 provided by the invention, add an amount of chippy Radix Notoginseng powder and Radix Notoginseng powder and Radix Ginseng powder's mixture respectively.Improve the effect of treatment like this, strengthen patient's body constitution.

Claims

1, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is characterized in that: 800-1400 is restrained Radix Salviae Miltiorrhizae, and 600-1200 restrains the Radix Astragali, and 600-1200 gram Folium Ginkgo extracts wherein active ingredient respectively after processing, be made into 1000 preparations.

2, according to the Chinese medicine preparation of the described this treatment cardiovascular and cerebrovascular disease of claim 1, it is characterized in that: with 1200 gram Radix Salviae Miltiorrhizaes, the 1000 gram Radixs Astragali, 1000 gram Folium Ginkgos extract wherein active ingredient respectively after processing, be made into 1000 preparations.

3, according to the Chinese medicine preparation of claim 1,2 described this treatment cardiovascular and cerebrovascular diseases, it is characterized in that: outside Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ginkgo extract, can also simultaneously or add a certain amount of Radix Ginseng, Radix Notoginseng respectively.

4, the manufacture method of the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease, it is characterized in that: the alcohol heating reflux of Radix Salviae Miltiorrhizae with 95-100% extracted, concentrate the tanshinol extract, medicinal residues are kept somewhere standby, get existing alcohol extraction----the resin method technology of Folium Ginkgo utilization and extract the Semen Ginkgo extrac (GBE) that obtains compositions such as apricot yellow ketone of argentiferous and bilobalide, adding decocting in water after Radix Salviae Miltiorrhizae decoction dregs and the Radix Astragali merging, ethanol will be added behind the liquid filtering, transfer to and contain ethanol 60-70%, technical finesse obtains extractum routinely, at last the tanshinol extract that obtains, Semen Ginkgo extrac and extractum merge, mix homogeneously is made powder after the oven dry, incapsulate.

5, according to the manufacture method of the Chinese medicine preparation of the described this treatment cardiovascular and cerebrovascular disease of claim 4, it is characterized in that: utilize prior art from Radix Salviae Miltiorrhizae, to extract tanshinone, from the Radix Astragali, extract astragaloside, from Folium Ginkgo, extract ginkgetin and bilobalide, it is mixed into paste, is made into soft capsule or drop pill.