CN107012057A - A kind of resist oxygen lack health liquor and preparation method thereof - Google Patents
A kind of resist oxygen lack health liquor and preparation method thereof Download PDFInfo
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- CN107012057A CN107012057A CN201710413238.0A CN201710413238A CN107012057A CN 107012057 A CN107012057 A CN 107012057A CN 201710413238 A CN201710413238 A CN 201710413238A CN 107012057 A CN107012057 A CN 107012057A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
- C12G3/06—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs with flavouring ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
Abstract
A kind of resist oxygen lack health liquor and preparation method thereof, it is related to health liquor technical field, the resist oxygen lack health liquor it is main by conic gymnadenia tuber, sealwort, jujube, Ke Zi, Amomum cardamomum, obtained the concentrated liquid of tradition Chinese medicine and white wine are made in one's early teens, Thick many candies >=100mg/L in the resist oxygen lack health liquor, general flavone >=80mg/L, total saposins >=60mg/L, the resist oxygen lack health liquor can meet the demand drunk, and have effects that resist oxygen lack again.When preparing the resist oxygen lack health liquor, Chinese medicine is first subjected to multi-reflow extraction with edible ethanol, extract solution is obtained, extract solution is centrifuged, filter, concentrated, the concentrated liquid of tradition Chinese medicine is obtained；The concentrated liquid of tradition Chinese medicine, white wine, rock sugar and pure water are mixed evenly again, stand, filter, again activated carbon is added in filtrate to stir, stand, filter, produce, the technique of the preparation method of the resist oxygen lack health liquor is simple, can fully extract the active ingredient in Chinese medicine, and incorporate in wine.
Description
Technical field
The present invention relates to health liquor technical field, and more particularly to a kind of resist oxygen lack health liquor and preparation method thereof.
Background technology
The developmental research to health liquor focuses mostly in wind-damp dispelling at present, anti-oxidant, regulation is immune, improvement is slept, warm kidney is helped
The directions such as sun, the most functional localization tradition of these health liquors, complicated components.Meanwhile, many consumers are drinking a certain amount of wine
After smart class drink, it may appear that anoxia phenomenon.Oxygen participates in human metabolism, is the indispensable material of normal activities, when
Tissue cannot get sufficient oxygen, or when can not make full use of oxygen, cell, tissue, the metabolism of organ, even function, form
Anomalous variation may all occur for structure.
With the increase, the quickening of rhythm of life, growth in the living standard of life stress, the crowd of anoxic is more and more wider,
Especially it is easy to occur the altitude sicknesses such as anoxic in highlands.Therefore, alcoholic beverages are considered as altitude environment always
Taboo, the alcoholic beverages such as common white spirit or other functional health wine are drunk in highlands, altitude sickness can be aggravated, gone out
The existing a series of symptoms based on anoxic.
But, many people have the demand drunk, and the work of the high altitude localities such as Qinghai-Tibet, study, tourism are gone to especially interiorly
And local people also have very strong demand of drinking.Accordingly, it would be desirable to develop a kind of health liquor with anoxia tolerance function, Ji Nengman
The demand that foot is drunk, can alleviate hypoxic conditions, especially altitude sickness again.
The content of the invention
It is an object of the invention to provide a kind of resist oxygen lack health liquor, the demand drunk can be met, there is resist oxygen lack again
Effect.
Another object of the present invention is to provide a kind of preparation method of resist oxygen lack health liquor, the technique of this method is simple,
Active ingredient in Chinese medicine can fully be extracted, and incorporated in wine.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of resist oxygen lack health liquor, and it is mainly made by the concentrated liquid of tradition Chinese medicine and white wine, resist oxygen lack health liquor
In Thick many candies >=100mg/L, general flavone >=80mg/L, total saposins >=60mg/L；Count by weight, the concentrated liquid of tradition Chinese medicine is main
It is made by following Chinese medicine：
Further, in present pre-ferred embodiments, count by weight, the concentrated liquid of tradition Chinese medicine is mainly by following Chinese medicine
It is made：
Further, in present pre-ferred embodiments, count by weight, Chinese medicine also includes 1~5 part of Radix Astragali and 1
~5 parts of ginsengs.
Further, in present pre-ferred embodiments, count by weight, Chinese medicine also include 1~5 part of spina date seed and
1~5 portion of Polygonum multiflower knotweed.
A kind of preparation method of above-mentioned resist oxygen lack health liquor, it comprises the following steps：
Chinese medicine is subjected to multi-reflow extraction with edible ethanol, extract solution is obtained, extract solution is centrifuged, filter, concentrated,
Obtain Thick many candies >=2000mg/L in the concentrated liquid of tradition Chinese medicine, the concentrated liquid of tradition Chinese medicine, general flavone >=1500mg/L, total saposins >=
1500mg/L；
The concentrated liquid of tradition Chinese medicine, white wine, rock sugar and pure water are mixed evenly, stands, filter, then addition is lived in filtrate
Property charcoal stirs, and stands, filters.
Further, in present pre-ferred embodiments, the method for refluxing extraction is：In being added every time in thing to be extracted
5~12 times of medicinal material gross weight, alcoholic strength is 30%~70%vol edible ethanols, refluxing extraction 2~4 times at 80~85 DEG C,
1.5~3 hours every time, collect the extract solution of each refluxing extraction.
Further, in present pre-ferred embodiments, the method for centrifugation is：Extract solution is carried out using supercentrifuge
Centrifuge, the rotating speed of centrifugation is 7000~9000r/min, and the time of centrifugation is 10~30min.
Further, in present pre-ferred embodiments, the method filtered after centrifugation is：Filter opening is used for less than 0.05 μm
Purpose ceramic-film filter the centrifugate obtained by centrifugation is separated by filtration.
Further, in present pre-ferred embodiments, the method for concentration is：Gained is filtered after being centrifuged using NF membrane
Filtrate be concentrated into crude drug concentration be 0.15~0.5g/ml the concentrated liquid of tradition Chinese medicine.
Further, in present pre-ferred embodiments, prepare resistance to using the concentrated liquid of tradition Chinese medicine, white wine, rock sugar and pure water
The method of anoxic health liquor is：Take 18~40ml of the concentrated liquid of tradition Chinese medicine, alcoholic strength be 40~60%vol 600~760ml of white wine,
30~60g of rock sugar, 1000ml is settled to pure water, is stirred, and is filtered after standing 30~50 days；Add and live in filtrate again
Property 1~4g of charcoal, stir, stand 45~75 days after filter.
The beneficial effect of the resist oxygen lack health liquor of the embodiment of the present invention and preparation method thereof is：The resistance to of the embodiment of the present invention lacks
The concentrated liquid of tradition Chinese medicine in oxygen health liquor count by weight it is main by 2~10 parts of conic gymnadenia tubers, it is 2~10 parts of sealworts, 2~10 parts big
Jujube, 2~10 parts of Ke Zi, 1~5 portion of Amomum cardamomum, 1~5 part be made in one's early teens, Thick many candies >=100mg/ in the resist oxygen lack health liquor
L, general flavone >=80mg/L, total saposins >=60mg/L, the resist oxygen lack health liquor can meet the demand drunk, and have resist oxygen lack again
Effect.When preparing the resist oxygen lack health liquor, Chinese medicine is first subjected to multi-reflow extraction with edible ethanol, extract solution is obtained,
Extract solution is centrifuged, filter, concentrated, the concentrated liquid of tradition Chinese medicine is obtained；The concentrated liquid of tradition Chinese medicine, white wine, rock sugar and pure water are mixed again and stirred
Mix uniform, stand, filter, then activated carbon is added in filtrate and stir, stand, filter, produce, the resist oxygen lack health liquor
The technique of preparation method is simple, can fully extract the active ingredient in Chinese medicine, and incorporate in wine.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional production that can be obtained by commercially available purchase
Product.
A kind of resist oxygen lack health liquor of the embodiment of the present invention and preparation method thereof is specifically described below.
The embodiment of the present invention provides a kind of resist oxygen lack health liquor, and it is mainly made by the concentrated liquid of tradition Chinese medicine and white wine, resist oxygen lack
Thick many candies >=100mg/L in health liquor, general flavone >=80mg/L, total saposins >=60mg/L.Count by weight, traditional Chinese drug inspissation
Liquid is mainly made by following Chinese medicine：2~10 parts of conic gymnadenia tubers；2~10 parts of sealworts；2~10 portions of jujubes；2~10 parts of Ke Zi；1~5
Part Amomum cardamomum；And 1~5 part in one's early teens.It is preferred that, Chinese medicine includes 4~8 parts of conic gymnadenia tubers；4~8 parts of sealworts；It is 4~8 parts big
Jujube；4~8 parts of Ke Zi；1~4 portion of Amomum cardamomum；And 1~4 part in one's early teens.It is furthermore preferred that Chinese medicine includes 5 parts of conic gymnadenia tubers；5 parts
Sealwort；5 portions of jujubes；5 parts of Ke Zi；2 portions of Amomum cardamomums；And 2 parts in one's early teens.
Conic gymnadenia tuber in Chinese medicine selected by the embodiment of the present invention is loaded in Tibetan medicine's medical book earliest《Four doctor's allusion quotations》In, its is sweet,
It is flat, enter lung channel, the spleen channel, stomach, there is relieving cough and asthma, Yishen Jianpi, qi-regulating and blood, analgesic.Modern pharmacology research
Think that conic gymnadenia tuber has the effect such as radioresistance, anti anoxia, protect liver, it is deep to be liked by the Tibetan area people in Tibetan area using extensive.
Sealwort in Chinese medicine selected by the embodiment of the present invention is sweet, flat, return lung, spleen, kidney channel,《Compendium of Materia Medica》Sealwort is recorded to fill out
Marrow, enrich blood, mend it is all it is empty, only fever and chills, tonifying middle-Jiao and Qi, enriching yin, five viscera settling, curing rheumatism, mend general debility, kidney tonifying, help muscles and bones, benefit
Temper stomach, embellish lung, promote the production of body fluid resistance to cold and heat, and effect is extensive.
Jujube in Chinese medicine selected by the embodiment of the present invention is sweet, temperature, returns spleen, stomach, tonifying middle-Jiao and Qi, nourishing blood and tranquilization.《Book on Chinese herbal medicine
It is newly organized》Described in jujube " logical nine orifices, and hundred medicines, support lung stomach, and QI invigorating, embellish lung is promoted the production of body fluid, and helps all warps, tonifying five zang organs ".Li Gao：" temperature
It is sweet with slow cloudy blood, and negative and positive with tonifying spleen through deficiency, adjust battalion to defend, born fluid ".
Myrobalan's bitter, acid, puckery, mild-natured, return lung, large intestine channel in Chinese medicine selected by the embodiment of the present invention, with astringing the lung, puckery
Intestines, lower gas, the effect of relieving sore-throat, Tibetan medicine think that with warming spleen and stomach for dispelling cold the function such as antifatigue is used extensive in Tibetan area.
Nutmeg acrid, bitter, warm in Chinese medicine selected by the embodiment of the present invention, returns spleen, stomach, large intestine channel, the puckery intestines of middle benefit gas, promoting the circulation of qi
Help digestion；Return lung, spleen, stomach in one's early teens, dampness elimination disappear ruffian, promoting the circulation of qi middle benefit gas, appetite-stimulating indigestion-relieving.《Book on Chinese herbal medicine is original》Record nutmeg tonifying spleen
Stomach, mill is stagnant, adjusts cold scattering gas very fast, and it is most suitable that weakness can not drink trencherman, and relieving alcoholism, and two medicines are with using, middle benefit gas, eliminating dampness, promoting the circulation of qi, solution
Wine protect liver.
The all medicines of Chinese medicine selected by the embodiment of the present invention are with use, the effect of middle benefit gas qi-regulating, help the five internal organs are played altogether, by above-mentioned Chinese medicine
The active ingredient of material is fully extracted, and forms traditional Chinese drug inspissation thing, then the traditional Chinese drug inspissation thing for gathering active ingredients from traditional Chinese medicinal is added
Into white wine, the resist oxygen lack health liquor with health-care efficacy is formed, the demand drunk can be met, the work(with resist oxygen lack
Effect.
Further, in order that resist oxygen lack health liquor is on the basis of with anoxia tolerance function, also with antifatigue
Effect, 1~5 part of Radix Astragali and 1~5 part of ginseng can also be included by preparing the Chinese medicine of the concentrated liquid of tradition Chinese medicine.In order that resist oxygen lack health care
Wine is on the basis of with anoxia tolerance function, and also with the effect of sleep is improved, Chinese medicine can also include 1~5 part of spina date seed
With 1~5 portion of Polygonum multiflower knotweed.In a word, the Chinese medicine with other effects can be taken according to the actual requirements, to be made with different efficacies
Combination property health liquor.
The embodiment of the present invention also provides a kind of preparation method of resist oxygen lack health liquor, and it comprises the following steps：
S1 is extracted：Standard compliant Chinese medicine is chosen, Chinese herbal medicine includes 2~10 parts of conic gymnadenia tubers；2~10 parts of sealworts；2~10
Part jujube；2~10 parts of Ke Zi；1~5 portion of Amomum cardamomum；And 1~5 part in one's early teens, 1~5 part of Radix Astragali and 1~5 part can also be included
Ginseng；1~5 part of spina date seed and 1~5 portion of Polygonum multiflower knotweed.Chinese medicine is subjected to multi-reflow extraction, specific method with edible ethanol
It is：The edible ethanol that 5~12 times of Chinese medicine gross weight, alcoholic strength are 30%~70%vol is added in thing to be extracted every time,
Refluxing extraction 2~4 times at 80~85 DEG C, 1.5~3 hours every time, collect the extract solution of each refluxing extraction.
S2 is centrifuged：Specifically use supercentrifuge, extract solution be centrifuged, the rotating speed of centrifugation for 7000~
9000r/min, the time of centrifugation is 10~30min.
S3 is filtered：Specifically use filter opening for less than 0.05 μm of purpose ceramic-film filter, the centrifugate obtained by centrifugation is entered
Row is separated by filtration, and filter residue is discarded, and filtrate is pending.
S4 is concentrated：Specifically use NF membrane, by the filtrate after centrifugation obtained by filtering be concentrated into crude drug concentration for 0.15~
0.5g/ml, preferably 0.3~0.5g/ml the concentrated liquid of tradition Chinese medicine, detection require Thick many candies >=2000mg/ in the concentrated liquid of tradition Chinese medicine
L, general flavone >=1500mg/L, total saposins >=1500mg/L, Thick many candies >=4000mg/L preferably wherein, general flavone >=
3500mg/L, total saposins >=2000mg/L.
S5 is prepared：The concentrated liquid of tradition Chinese medicine, white wine, rock sugar and pure water are mixed evenly, stands, filter, then in filtrate
Middle addition activated carbon stirs, and stands, filters.Specific method is：Take 18~40ml of the concentrated liquid of tradition Chinese medicine, alcoholic strength for 40~
60%vol 600~760ml of white wine, 30~60g of rock sugar, is settled to 1000ml with pure water, stirs, and stands 30~50
Filtered after it；1~4g of activated carbon is added in filtrate again, is stirred, is filtered after standing 45~75 days, filtrate is resist oxygen lack
Health liquor, detection requires Thick many candies >=100mg/L in resist oxygen lack health liquor, general flavone >=80mg/L, total saposins >=60mg/L.
The embodiment of the present invention is first extracted to Chinese medicine, centrifuged, ceramic membrane separation by the technique and equipment of modernization
Etc. process, extract in Chinese medicine most functional components, then by processes such as NF membrane concentrations, isolate invalid components and
Impurity, realizes and carries out abundant extracting and developing, purifying to the active ingredient of Chinese medicine, obtain the concentrated liquid of tradition Chinese medicine, give full play to the modern times
Industrialized production advantage.This method high efficiency extracts the active principle of compound medicinal material, with the white wine knot with warm positive dredging collateral effect
Close, be allowed to combine together, on the one hand play a part of one-plus-one more than two, on the other hand, acted on, disappeared by the Chinese medicine of this compound
Except the body anoxic burden that white wine is brought, and the effect of resist oxygen lack can be strengthened to a certain extent.According to the system of the embodiment of the present invention
Resist oxygen lack health liquor made from Preparation Method, wine body is amber color liquid, and clear is glossy, and elegant fragrance is coordinated, mouthfeel alcohol
In comfortable, it is plentiful mellow and full.The security examination carried out through function of health food inspection center of Tongji Medical College, Huazhong Science and Technology Univ.
Test, hypoxia endurance test result shows：According to resist oxygen lack health liquor safety non-toxic made from the preparation method of the embodiment of the present invention, tool
There is resist oxygen lack.
The feature and performance to the present invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of resist oxygen lack health liquor of the present embodiment, it is made according to following preparation method：
(1) extract：Choose standard compliant Chinese medicine：600g conic gymnadenia tubers, 600g sealworts, 600g jujubes, 600g Ke Zi,
300g Amomum cardamomums, 300g in one's early teens, Chinese medicine gross weight 3Kg.The edible ethanol that 50L, alcoholic strength are 50%vol is added every time,
Refluxing extraction 3 times at 80~85 DEG C, 2 hours every time, the common 138.5L of extract solution that collection is 3 times.
(2) centrifuge：Said extracted liquid is placed in supercentrifuge and centrifuged, rotating speed is 8500r/min, centrifugation
20min, obtains centrifugate 134L.
(3) filter：Centrifugate after above-mentioned centrifugation is separated by filtration by filter opening for 0.05 μm of ceramic membrane filter machine, obtained
To filtrate 114.6L, filter residue is discarded.
(4) concentrate：Filtrate obtained by filtering after above-mentioned centrifugation is concentrated into by 15L using NF membrane, obtained crude drug concentration
For 0.17g/ml concentrate, Thick many candies content is 2100mg/L after testing, and general flavone content is 1830mg/L, total saponin content
For 1890mg/L；
(5) prepare：High quality liquor 76L, rock sugar 6Kg that above-mentioned the concentrated liquid of tradition Chinese medicine 3.79L, alcoholic strength are 50%vol are taken, is used
Pure water is settled to 100L, stirs, and is filtered after standing 30 days, the activated carbon that 100g is added in filtrate stirs, quiet
Put and filtered after 45 days, filtrate is that alcoholic strength prepared by the present embodiment is thick in 38.2%vol resist oxygen lack health liquors, wine body
Polyoses content is 132.4mg/L, general flavone 138.3mg/L, total saposins 97.9mg/L.
Embodiment 2
A kind of resist oxygen lack health liquor of the present embodiment, it is made according to following preparation method：
(1) extract：Choose standard compliant Chinese medicine：800g conic gymnadenia tubers, 600g sealworts, 700g jujubes, 700g Ke Zi,
300g Amomum cardamomums, 300g in one's early teens, Chinese medicine gross weight 3.4Kg.60L, 30%vol edible ethanol are added every time, 80~85
Refluxing extraction 3 times at DEG C, 2 hours every time, the extract solution 168.5L that collection is 3 times.
(2) centrifuge：Said extracted liquid is placed in supercentrifuge and centrifuged, rotating speed is 7500r/min, centrifugation time
For 25min, centrifugate 163.8L is obtained.
(3) filter：Centrifugate after above-mentioned centrifugation is separated by filtration by filter opening for 0.05 μm of ceramic membrane filter machine, obtained
Filtrate 154.5L, filter residue is discarded.
(4) concentrate：Filtrate obtained by filtering after above-mentioned centrifugation is concentrated into by 12L using NF membrane, obtained crude drug concentration
For 0.37g/ml the concentrated liquid of tradition Chinese medicine, Thick many candies content therein is 4470.8mg/L after testing, and general flavone content is 3980mg/
L, total saponin content is 2830.5mg/L.
(5) prepare：Above-mentioned the concentrated liquid of tradition Chinese medicine 3.37L, 50%vol high quality liquor 76L, rock sugar 6Kg are taken, it is fixed with pure water
Hold to 100L, stir, filtered after standing 30 days；200g activated carbon is added in filtrate again, is stirred, 45 days are stood
After filter, the Thick many candies content that filtrate is in the resist oxygen lack health liquor prepared by the present embodiment, wine body is 145.7mg/L, always
Flavones content is 120.3mg/L, and total saponin content is 89.5mg/L.
Embodiment 3
A kind of resist oxygen lack health liquor of the present embodiment, it is made according to following preparation method：
(1) extract：Choose standard compliant Chinese medicine：1000g conic gymnadenia tubers, 800g sealworts, 700g jujubes, 700g Ke Zi,
500g Amomum cardamomums, 500g in one's early teens, Chinese medicine gross weight 4Kg.55L, 40%vol edible ethanol are added every time, at 80~85 DEG C
Lower refluxing extraction 3 times, 2 hours every time, collects the extract solution 153.5L of 3 times.
(2) centrifuge：Said extracted liquid is placed in supercentrifuge and centrifuged, rotating speed is 7000r/min, centrifugation time
For 30min, centrifugate 148.8L is obtained.
(3) filter：Centrifugate after above-mentioned centrifugation is separated by filtration by filter opening for 0.05 μm of ceramic membrane filter machine, obtained
Filtrate 139.5L, filter residue is discarded.
(4) concentrate：Filtrate obtained by filtering after above-mentioned centrifugation is concentrated into by 15L using NF membrane, obtaining crude drug concentration is
0.36g/ml the concentrated liquid of tradition Chinese medicine, Thick many candies content therein is 4410.9mg/L after testing, and general flavone content is 3900mg/L,
Total saponin content is 2755.8mg/L.
(5) prepare：The concentrated liquid of tradition Chinese medicine 3.47L, 50%vol high quality liquor 76L, rock sugar 6Kg are taken, is settled to pure water
100L, stirs, and is filtered after standing 30 days；300g activated carbon is added in filtrate again, is stirred, mistake after standing 45 days
Filter, filtrate is that the Thick many candies content in the resist oxygen lack health liquor prepared by the present embodiment, wine body is 147mg/L, and general flavone contains
Measure as 122.6mg/L, total saponin content is 88mg/L.
Embodiment 4
A kind of resist oxygen lack health liquor of the present embodiment, it is made according to following preparation method：
(1) extract：Choose standard compliant Chinese medicine：1200g conic gymnadenia tubers, 1000g sealworts, 600g jujubes, 600g Ke Zi,
400g Amomum cardamomums, 400g in one's early teens, Chinese medicine gross weight 4.2Kg.45L, 60%vol edible ethanol are added every time, 80~85
Refluxing extraction 3 times at DEG C, 2 hours every time, the extract solution 124.5L that collection is 3 times.
(2) centrifuge：Said extracted liquid is placed in supercentrifuge and centrifuged, rotating speed is 8000r/min, centrifugation time
For 20min, centrifugate 119.8L is obtained.
(3) filter：Centrifugate after above-mentioned centrifugation is separated by filtration by filter opening for 0.05 μm of ceramic membrane filter machine, obtained
Filtrate 110.4L, filter residue is discarded.
(4) concentrate：Filtrate obtained by filtering after above-mentioned centrifugation is concentrated into by 15L using NF membrane, obtaining crude drug concentration is
0.34g/ml the concentrated liquid of tradition Chinese medicine, Thick many candies content therein is 4320mg/L after testing, and general flavone content is 3844.3mg/L,
Total saponin content is 2655.2mg/L.
(5) prepare：Above-mentioned the concentrated liquid of tradition Chinese medicine 3.68L, 50%vol high quality liquor 76L, rock sugar 6Kg are taken, it is fixed with pure water
Hold to 100L, stir, filtered after standing 30 days；400g activated carbon is added in filtrate again, is stirred, 45 days are stood
After filter, the Thick many candies content that filtrate is in the resist oxygen lack health liquor prepared by the present embodiment, wine body is 145.7mg/L, always
Flavones content is 123.4mg/L, and total saponin content is 89mg/L.
Embodiment 5
A kind of resist oxygen lack health liquor of the present embodiment, it is made according to following preparation method：
(1) extract：Choose standard compliant Chinese medicine：800g conic gymnadenia tubers, 600g sealworts, 700g jujubes, 700g Ke Zi,
300g Amomum cardamomums, 300g in one's early teens, the 300g Radixs Astragali, 300g ginsengs, Chinese medicine gross weight 4Kg.60L, 30%vol food are added every time
With ethanol, refluxing extraction 2 times at 80~85 DEG C, 3 hours every time, the extract solution 167.1L that collection is 2 times.
(2) centrifuge：Said extracted liquid is placed in supercentrifuge and centrifuged, rotating speed is 7500r/min, centrifugation time
For 25min, centrifugate 163.8L is obtained.
(3) filter：Centrifugate after above-mentioned centrifugation is separated by filtration by filter opening for 0.05 μm of ceramic membrane filter machine, obtained
Filtrate 154.5L, filter residue is discarded.
(4) concentrate：Filtrate obtained by filtering after above-mentioned centrifugation is concentrated into by 12L using NF membrane, obtained crude drug concentration
For 0.4g/ml the concentrated liquid of tradition Chinese medicine, Thick many candies content therein is 4570.8mg/L after testing, and general flavone content is 4080mg/
L, total saponin content is 2930.5mg/L.
(5) prepare：Above-mentioned the concentrated liquid of tradition Chinese medicine 2.6L, 50%vol high quality liquor 70L, rock sugar 5Kg are taken, it is fixed with pure water
Hold to 100L, stir, filtered after standing 40 days；200g activated carbon is added in filtrate again, is stirred, 60 days are stood
After filter, the Thick many candies content that filtrate is in the resist oxygen lack health liquor prepared by the present embodiment, wine body is 152.7mg/L, always
Flavones content is 128.3mg/L, and total saponin content is 92.5mg/L.
Embodiment 6
A kind of resist oxygen lack health liquor of the present embodiment, it is made according to following preparation method：
(1) extract：Choose standard compliant Chinese medicine：1200g conic gymnadenia tubers, 1000g sealworts, 600g jujubes, 600g Ke Zi,
400g Amomum cardamomums, 400g in one's early teens, 400g spina date seeds, 400g Polygonum multiflower knotweeds, Chinese medicine gross weight 5Kg.45L, 60%vol are added every time
Edible ethanol, refluxing extraction 4 times at 80~85 DEG C 1.5 hours every time, collect the extract solution 129.5L of 4 times.
(2) centrifuge：Said extracted liquid is placed in supercentrifuge and centrifuged, rotating speed is 8000r/min, centrifugation time
For 20min, centrifugate 123.8L is obtained.
(3) filter：Centrifugate after above-mentioned centrifugation is separated by filtration by filter opening for 0.05 μm of ceramic membrane filter machine, obtained
Filtrate 113.4L, filter residue is discarded.
(4) concentrate：Filtrate obtained by filtering after above-mentioned centrifugation is concentrated into by 15L using NF membrane, obtaining crude drug concentration is
0.45g/ml the concentrated liquid of tradition Chinese medicine, Thick many candies content therein is 4521mg/L after testing, and general flavone content is 3957.3mg/L,
Total saponin content is 2741.2mg/L.
(5) prepare：Above-mentioned the concentrated liquid of tradition Chinese medicine 2.5L, 50%vol high quality liquor 65L, rock sugar 4.5Kg are taken, pure water is used
100L is settled to, is stirred, is filtered after standing 50 days；400g activated carbon is added in filtrate again, is stirred, 75 are stood
Filtered after it, the Thick many candies content that filtrate is in the resist oxygen lack health liquor prepared by the present embodiment, wine body is 154.7mg/L,
General flavone content is 128.4mg/L, and total saponin content is 92mg/L.
Every detection is carried out to the resist oxygen lack health liquor in embodiment 1~4 below.
First, detection project：Component content is detected.Contained each component content in resist oxygen lack health liquor in embodiment 1~4
As a result it is as shown in table 1.
Each component content in the resist oxygen lack health liquor of table 1
2nd, detection project：Food safety evaluation on toxicology.
The resist oxygen lack health liquor 2500ml in Example 1~4, corresponding marked as sample 1, sample 2, sample 3, sample respectively
Product 4, send to function of health food inspection center of Tongji Medical College, Huazhong Science and Technology Univ. and are detected.Test basis reference《Protect
Health food is examined and assessment technique specification》(version in 2003).Human body recommends wine body intake to be 100ml daily, by adult 60kg
Batheroom scale, it is 1.67ml/kg.bw to recommend intake dosage.
The food safety evaluation on toxicology report of 1~sample of sample 4 shows：Half lethal dose of the wine body to mouse
(LD50)>200.0ml/kg.bw, true border innocuous substance.Salmonella reversion test, Micronuclei In The Mouse Bone Marrow test and sperm malformation test are equal
For feminine gender.In 30 days feeding trials of rat, by 25 times of human body recommended intake, 50 times, 100 times (i.e. 41.7,83.3,
Tested material 167.0ml/kg.bw) is given, and sets up Normal group, measurement result shows the growth of each group rat body weight, food profit
With indexs such as rate, dirty body ratio, hematology and serum biochemistries in range of normal value, each dosage group is with accordingly compareing group difference
There is no conspicuousness；The Poisoning lesion relevant with tested material is not found yet in liver,kidney,spleen, stomach and intestine, ovary and testopathy inspection.
According to《Health food is examined and assessment technique specification》(version in 2003), judges that the resist oxygen lack in embodiment 1~4 is protected
Strong wine is examined by food safety toxicology.
3rd, detection project：Resist oxygen lack performance detection.
The resist oxygen lack health liquor 2500ml in Example 1~4, corresponding marked as sample 5, sample 6, sample 7, sample respectively
Product 8, send to function of health food inspection center of Tongji Medical College, Huazhong Science and Technology Univ. and are detected.Test basis reference《Protect
Health food is examined and assessment technique specification》(version in 2003).Human body recommends wine body intake to be 100ml daily, by adult 60kg
Batheroom scale, it is 1.67ml/kg.bw to recommend intake dosage.
Resist oxygen lack (animal experiment) plus survey result are with judging：Animal is using cleaning BALB/c mouse, and human body intake is pressed in experiment
10 times, 20 times, 30 times of amount sets 16.7 respectively, 33.4, tri- dosage groups of 50.0ml/Kg.bw, while setting negative control group and solvent
Control group.Compared with negative control group and solvent control group：A. the resist oxygen lack health liquor normal pressure anoxia tolerance test in sample 5~8
As a result show, 10 times, 20 times, 30 times of three dosage group Hypoxia under normal pressure compared with negative control group and solvent control group, it is poor
Different there are no significant (by taking sample 5 as an example, F=0.611, P=0.657), illustrates that tested material does not extend mouse oxygen deficit tolerance
The effect of time；B. the resist oxygen lack health liquor natrium nitrosum poisoning survival test in sample 5~8 shows that mouse gives tested material
Afterwards, natrium nitrosum poisoning the time-to-live have different degrees of extension, wherein 20 times, the poisoning time-to-live of 30 multiple dose groups with
Negative control group is compared, and difference has pole conspicuousness (P<0.01)；C. the resist oxygen lack health liquor acute cerebral ischemia examination in sample 5~8
Test and show, 20, the breathing time of 30 times of two dosage group compared with solvent group, difference has pole conspicuousness (P<0.01), show tested
Thing has the effect of breathing time after extension Acute cerebral ischemia in mice.
According to《Health food is examined and assessment technique specification》(version in 2003), judges that the resist oxygen lack in embodiment 1~4 is protected
Strong drinking utensils is improved the function of anoxia endurance.
In summary, the resist oxygen lack health liquor of the embodiment of the present invention can meet the demand drunk, and have resist oxygen lack again
Effect；The technique of the preparation method of the resist oxygen lack health liquor of the embodiment of the present invention is simple, can fill the active ingredient in Chinese medicine
Divide and extract, and incorporate in wine.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of resist oxygen lack health liquor, it is characterised in that it is mainly made by the concentrated liquid of tradition Chinese medicine and white wine, the resist oxygen lack health care
Thick many candies >=100mg/L in wine, general flavone >=80mg/L, total saposins >=60mg/L；Count by weight, the traditional Chinese drug inspissation
Liquid is mainly made by following Chinese medicine：
2. resist oxygen lack health liquor according to claim 1, it is characterised in that count by weight, the concentrated liquid of tradition Chinese medicine
Mainly it is made by following Chinese medicine：
3. resist oxygen lack health liquor according to claim 1, it is characterised in that count by weight, the Chinese medicine is also wrapped
Include 1~5 part of Radix Astragali and 1~5 part of ginseng.
4. resist oxygen lack health liquor according to claim 1, it is characterised in that count by weight, the Chinese medicine is also wrapped
Include 1~5 part of spina date seed and 1~5 portion of Polygonum multiflower knotweed.
5. a kind of preparation method of resist oxygen lack health liquor as claimed in claim 1, it is characterised in that it comprises the following steps：
The Chinese medicine is subjected to multi-reflow extraction with edible ethanol, extract solution is obtained, the extract solution is centrifuged, filtered,
Concentration, obtains Thick many candies >=2000mg/L in the concentrated liquid of tradition Chinese medicine, the concentrated liquid of tradition Chinese medicine, general flavone >=1500mg/L, total soap
Glycosides >=1500mg/L；
The concentrated liquid of tradition Chinese medicine, white wine, rock sugar and pure water are mixed evenly, stands, filter, then addition is lived in filtrate
Property charcoal stirs, and stands, filters.
6. the preparation method of resist oxygen lack health liquor according to claim 5, it is characterised in that the method for the refluxing extraction
It is：The edible second that 5~12 times of the Chinese medicine gross weight, alcoholic strength are 30%~70%vol is added in thing to be extracted every time
Alcohol, refluxing extraction 2~4 times at 80~85 DEG C 1.5~3 hours every time, collect the extract solution of each refluxing extraction.
7. the preparation method of resist oxygen lack health liquor according to claim 5, it is characterised in that the method for the centrifugation is：
The extract solution is centrifuged using supercentrifuge, the rotating speed of the centrifugation is 7000~9000r/min, it is described from
The time of the heart is 10~30min.
8. the preparation method of resist oxygen lack health liquor according to claim 5, it is characterised in that the side filtered after the centrifugation
Method is：Filter opening is used to be separated by filtration the centrifugate obtained by centrifugation for less than 0.05 μm of purpose ceramic-film filter.
9. the preparation method of resist oxygen lack health liquor according to claim 5, it is characterised in that the method for the concentration is：
Use NF membrane that the filtrate obtained by filtering after centrifugation is concentrated into the concentrated liquid of tradition Chinese medicine of the crude drug concentration for 0.15~0.5g/ml.
10. the preparation method of resist oxygen lack health liquor according to claim 5, it is characterised in that use the traditional Chinese drug inspissation
The method that liquid, the white wine, the rock sugar and the pure water prepare the resist oxygen lack health liquor is：Take the concentrated liquid of tradition Chinese medicine
18~40ml, alcoholic strength are the 40~60%vol 600~760ml of white wine, the 30~60g of rock sugar, use the pure water
1000ml is settled to, is stirred, is filtered after standing 30~50 days；1~the 4g of activated carbon is added in the filtrate again, is stirred
Mix uniform, filtered after standing 45~75 days.
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| CN113717819A (en) * | 2021-07-28 | 2021-11-30 | 劲牌有限公司 | Method for delaying hydrolysis of low alcohol ester |
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