CN101514318A - Tibetan pharmaceutical health care wine - Google Patents

Abstract

The invention belongs to health care wine, especially provides a health care wine prepared from Qinghai-Tibet Platean non-pollution natural high-quality rare Tibetan Chinese medicament, such as Chinese caterpillar fungus, gen-seng, Tibetan Radix Astragali, Tibetan matrimony vine, Tibetan desertliving cistanche, Tibetan cynomorium songaricum, Tibetan Polygonatum Canaliculatum rhizome, Tibetan rhodiola sachalinensis and Tibetan Chinese angelica, and prepared by advanced process. The preparation process of the product includes steps of mixing and crushing the raw materials into two equal parts, using water to lixiviate for two times, using spirit to lixiviate for one time, mixing, allocating, uniformly stirring, depositing, filtering, filling, capping, and checking package. The product contains raw materials such as Tibetan Chinese caterpillar fungus, gen-seng, Tibetan Radix Astragali, Tibetan matrimony vine, Tibetan desertliving cistanche, Tibetan cynomorium songaricum, Tibetan Polygonatum Canaliculatum rhizome, Tibetan rhodiola sachalinensis and Tibetan Chinese angelica, and effects of delaying senescence, enhancing sexual function, increasing immunity, and resisting fatigue and anoxia.

Description

Tibetan pharmaceutical health care wine

One, technical field:

The invention belongs to functional health wine, especially hide Chinese medicine, Chinese caterpillar fungus, genseng, the Tibetan Radix Astragali, hide matrimony vine, hide cynomorium songaricum, hide Herba Cistanches, hide raw materials such as sealwort, safranine red-spotted stonecrop, ZANGDANGGUI, the health promoting wine of taking advanced technologies to process with the free of contamination natural high-quality in Qinghai-Tibet Platean.

Two, background technology:

This invention is to hide Chinese caterpillar fungus, genseng, the Tibetan Radix Astragali, hide matrimony vine, hide cynomorium songaricum, hide Herba Cistanches, to hide the health promoting wine that raw materials such as sealwort, safranine red-spotted stonecrop, ZANGDANGGUI are made.Have delay senility, effect such as sexual function improving, raising immunizing power, anti-fatigue anoxia-tolerance.Existing market does not also have like product to occur, and develops this product and can be a kind of novel health promoting wine to alcohol industry is provided, and human body is had the good health care effect.Soft, the good taste of mouthfeel is the superior good merchantable brand of drinks.

Three, summary of the invention:

Along with the economic constantly development of China, national life improves constantly and the expection of human longevity prolongs, and people's health care Italian type strengthens day by day, and is especially more strong to quality of life and good health and a long life.Development of the West Regions, being open to traffic of Qinghai-Tibet Railway attracted a large amount of domestic and international investment entrepreneurs, researcher and a large amount of tourists from both home and abroad to come beautiful Qinghai-Tibet sightseeing tour.Bring fast development for local tour industry and economy, hide the Chinese medicine health-care industry development also for the Qinghai-Tibet Platean and bring opportunity.Because the natural ecological environment that the Qinghai-Tibet Platean is unique, these are hidden Chinese medicines and have the high characteristics of natural pollution-free, active effect, allow the plateau Cordyceps sinensis, Stigma Croci, safranine red-spotted stonecrop, hide characteristic famous and precious Tibetan medicine materials such as Herba Herminii, barley wine by common people understand, the name poplar is overseas.Have benefited from the Tibetan natural resources of Chinese medicinal materials advantage and the ecotope advantage of snowy region plateau uniqueness just, these high-quality resources are just enjoying increasing people and are paying close attention to.It is the health industry of raw material that Chinese medicine is hidden in exploitation, will bring huge business opportunity, has bright development prospect.

Four, composition of raw materials: hide Chinese caterpillar fungus 1.0-1.5 kilogram, hide Radix Astragali 4-6 kilogram, hide matrimony vine 3-5 kilogram, hide cynomorium songaricum 2-4 kilogram, hide Herba Cistanches 3-5 kilogram, hide sealwort 5-6 kilogram, safranine red-spotted stonecrop 3-4 kilogram, ZANGDANGGUI 5-6 kilogram, highland barley liquor 100L.

Five, technical scheme:

(1), hiding Chinese caterpillar fungus hides Cordyceps extract (Chinese caterpillar fungus): being to be grown in a kind of microorganism (fungus body) under the Qinghai-Tibet 3500-4500 rice particular surroundings, is that China's Tibetan medicine is protected the medicinal material of Chinese medicine simply in the storehouse.In global Chinese, there is widely U.S.A transcribe, Chinese caterpillar fungus is always regarded as the panacea of treatment weakness by common people, be (Chinese caterpillar fungus, pilose antler, genseng) first of the herbal medicine " three mend ", enjoy the good name of " the east legend are very precious " in the world and be described as disease-resistant anti-cancer to good Chinese medicinal materials, bring the world health by the expert.

Chinese caterpillar fungus is an ergot composite family fungi Cordyceps, colonizes in stroma and larva cadaveric complex on the Hepialidae insect larvae.Warm in nature, the flavor sweet, return kidney, lung channel.Have nourishing lung and kidney, mend smart marrow, balancing yin and yang, hemostasis and phlegm, the function of delaying senility of giving birth to.To cancer-resisting, anaemia weakness, hepatitis B, raising immune function of human body work the effect of consolidating.

Chemical ingredients: Chinese caterpillar fungus contains saponins, cordycepic acid, Cordyceps polysaccharide, superoxide-dismutase various active goods and materials such as (SOD), and amino acid, VITAMIN and trace element, selenium, calcium, potassium, manganese, zinc etc.

Pharmacological action: 1, regulate immunologic function: (1) is to the enhancement of monokaryon one macrophage system function: Cordyceps water extract can obviously improve colloid carbon clearance degree in the mouse blood, to the mouse monokaryon phagocytic cell, peritoneal macrophage, phagocytic functions such as reticuloendothelial system have tangible activation.It is bright to engulf test card in the body, and this product can significantly improve the phagocytic function of Turnover of Mouse Peritoneal Macrophages.

(2) to the influence of body immunity: Cordyceps and Cordyceps polysaccharide can make mice serum 1gE content obviously increase, and have improved the serum hemolysin level, induce splenocyte to express the IL-2 acceptor.

(3) increase natural killer cell (NK) activity: studies show that the administration of Chinese caterpillar fungus ethanol-extracted liquid can obviously strengthen the killing activity of the inside and outside NK pair cell of mouse body.

2, kidney invigorating and YANG supporting: Chinese caterpillar fungus can be regulated renal function, and tonifying yin is yang-tonifying again, and is not empty not high, reinvigoration, the strong kidney of help.But Chinese caterpillar fungus also has male hormone effect production of sperm, and to impotence and seminal emission, the disease of the insufficiency of kidney-YANG of soreness of waist and knee joint is effective in cure.

3, adjusting sexual function: Chinese caterpillar fungus has certain androgen-like action, can make the weightening finish of castration male rat childhood seminal vesicle.Male mouse blood plasma cortisol content is increased for mouse stomach, the suprarenal gland cholesterol is increased, the suprarenal gland weightening finish has preventive and therapeutic effect to " deficiency of yang type " due to the oxidation cortisone, and sexual disorder is had the adjusting restitution.In addition, Chinese caterpillar fungus also has the synthetic and secretion of promotion and adrenal cortex reinforcing hormone.

4, anti-ageing: Chinese caterpillar fungus can alleviate the infringement to the body biological process that descends and cause thus owing to the old and feeble maincenter catecholamine levels that causes, and removes human body harmful's free radical, delays senility the effect of good health and a long life thereby play.Anti-ageing test-results shows, the Cordyceps polysaccharide of different sources all has in various degree prolongation effect to life span of drosophila melanogaster, thereby the proof Cordyceps polysaccharide has function in delaying senility.

5, anti-oxidant: Chinese caterpillar fungus can suppress lipid peroxidation and generate; Strengthen red corpuscle superoxide dismutase vigor.Cordyceps can suppress MDA in rat, the mouse brain.According to another report, TaiWan, China ancient Chinese name for Venus hospital carries out human trial to the nephrotic, finds to take Chinese caterpillar fungus after 1 month, and tangible anti-oxidant reaction is arranged in the blood.

6, beautifying face and moistering lotion: in present medical circle, in the confessed seven big class anti-aging beauty-care activeconstituentss, Chinese caterpillar fungus just contains five big classes, is respectively polysaccharide, amino acid, polypeptide (protein), nucleic acid and VITAMIN (other two big flavonoid and soap class).Chinese caterpillar fungus also has endocrine regulation, and tangible calmness and syngignoscism are arranged, and has the beautifying face and moistering lotion effect.

7, treatment cardiovascular diseases, strengthen cardio and vascular function: Chinese caterpillar fungus has the adjusting cardio and vascular function, has hypotensive, reducing blood-fat and reduction myocardial consumption of oxygen are improved cardiac muscle and cerebral anoxia, anti-arrhythmia, antifatigue and the anti-ageing effect of waiting for a long time make the running of cardiovascular and cerebrovascular normal health.

8, antitumor: Chinese caterpillar fungus has human activin DNA synthetic function, can strengthen autoimmunity, and white corpuscle is engulfed the oncocyte encirclement of the bad sex change of human body and produced normal cell, oncocyte is reduced or disappearance, and tumour also can slowly be contracted to disappearance.The Chinese caterpillar fungus water decoction has certain restraining effect to mouse S180.Antitumous effect to Ismipur has enhancement, and the growth of mouse subcutaneous transplanting lung knurl is had the obvious suppression effect.According to another report, Chinese caterpillar fungus mouse entity S180 knurl etc. is had restraining effect, intravenous effect is 100%.The average inhibitory rate 45.71% of report is also arranged.

Cordyceps polysaccharide: have anticancer and immunosuppressive action: with lotus knurl BALB/C is that model is observed Cordyceps polysaccharide and can obviously be suppressed tumor growth. studies show that, Cordyceps polysaccharide can activate phagocytic function and DTH reaction, directly or indirectly discharge the cytotoxic factor killing tumor cell, suppress tumor growth, prove that Cordyceps polysaccharide has obvious antineoplastic.

9, protect the liver: Chinese caterpillar fungus has improves the effect that chronic type b, hepatitis C symptom have the virus removed.Surface antigen is turned out cloudy; make liver function recovery normal; reach the effect for the treatment of both principal and secondary aspect of disease; according to another report; cordyceps sinensis polysaccharide liposome (CPL) can significantly reduce the activity of ALT and AST in the liver injury mice serum; murine liver tissue, pathological section show, the CPL of senior middle school's agent has provide protection to the CPL that the mouse liver injury due to amino half sugar of D-and middle agent are to the liver injury due to four carbonoxides.The prompting Chinese caterpillar fungus has function for protecting liver and reducing enzyme activity.Chinese caterpillar fungus has certain preventive and therapeutic effect to hepatitis B in addition.

10, strengthen the cardiac pulse ability, Cordyceps mycelium extract 100ug/ml can obviously strengthen the active contraction intensity of rat in the atrium, prolongs systolic time.

11, antifatigue, high temperature resistant, hypoxia tolerance: with Cordyceps mycelium extract 100-200mg/kg mouse swimming test, the result proves that swimming time prolongs, and has the resistivity under physical strength reinforcing and the stressed condition.Chinese caterpillar fungus group mouse stomach has the high temperature resistant effect of obvious anti-fatigue.The abdominal injection Chinese caterpillar fungus has the increase resisting oxygen lack.

It is reported that the double blind trial of Medical School of Peking University confirms, Chinese caterpillar fungus far surpasses genseng in the lifting of physical efficiency and explosive power, the Chinese female player who in 1993 and Olympic Games Women's 1000m in 1994 race, wins the title, to make finish the full distance in 42 seconds of whole world motion circle shock with breaking a record. its reason is that the sportsmen takes Cordyceps extract for a long time, to promote explosive power, so the health effect of Chinese caterpillar fungus is subjected to attracting attention of west biochemical medicine circle.

12, hypotensive, reducing blood-fat: the factor that causes cardiovascular disorder is a lot, but mainly is that blood fat increases and causes arteriosclerosis to cause, therefore controlling hyperlipemia disease just becomes the key of preventing and treating cardiovascular disorder.Chinese caterpillar fungus confirms through the clinical observation of strictness, and serum total cholesterol (CT) concentration, serum triglyceride (TG) concentration are significantly descended, have significantly hypotensive, the effect of reducing blood-fat.

13, hypoglycemic: the CHWC polysaccharide in the Chinese caterpillar fungus thalline, abdominal injection 50mg/kg has significant hypoglycemic activity, onset in 3 hours.To the alloxan diabetes model mice, the obvious functions of blood sugar effect is arranged, descend about 40% than control group.

14, antiasthmatic-antitussive has better curative effect to pulmonary emphysema, trachitis: be the common respiratory tract infection of respiratory system disease spring, pulmonary infection, disease such as chronic cough, asthma, because its clinical shape is to influenza and for similar, a lot of people do not attract great attention, thus delay treatment.Clearing lung-heat good medicine Chinese caterpillar fungus is discharged by the guiding fester, removes outmoded phlegm piece, nourishes lung tissue, the activate immunity function is removed dyspnoea, will effect a permanent cure, consolidates, nourish and combine, fundamentally improve lung functions, recover the mucous membrane activity, improve immunologic function.

The also expansible bronchial smooth muscle of Chinese caterpillar fungus strengthens suprarenin, and to the lung qi loss, the lung power consumption hinders that void is breathed heavily, the disease of phthisical cough phlegm blood has a significant effect.It is relevant with deficiency of both the lung and kidney that the traditional Chinese medical science thinks that old-slow-bronchial tube is sent out the people repeatedly.Chinese caterpillar fungus is warm in nature, mends the lean marrow, nourishing lung and kidney, and this thing is protected lung qi." from new compilation of materia medica " record, Chinese caterpillar fungus protects the lung kidney-nourishing, and hemostasis and phlegm ends the phthisical cough effect.Its nature and flavor, sweet, warm, go into lung, kidney channel.But it is bright to go into the lung tonifying lung, and following kidney is qi-restoratives the moon then, has beneficial lung and protects lung, relieving cough and reducing sputum, hemostasis tonifying deficiency, effects such as strong vital essence.Be usually used in treating that chronic cough void is breathed heavily, phthisical cough spitting of blood, the moon are withered, seminal emission, soreness of waist and knee joint etc.The chronic cough void that the treatment old-slow-bronchial tube causes is breathed heavily.

15, qi-restoratives, postoperative rehabilitation effect, Chinese caterpillar fungus has anticancer, antiviral special efficacy, Chinese caterpillar fungus

Polysaccharide has strengthening the body resistance to consolidate the constitution, improves the effect of immunologic function, contains abundant VITAMIN and selenium element in the Chinese caterpillar fungus; Can both the enhancing body immunity system, build up resistance.Patient has consumed a large amount of nutritive substances during sick, take the nutritive ingredient that Chinese caterpillar fungus just in time can be replenished the various urgent needs of body this moment, recovers patient's muscle power, and is very favourable to physical rehabilitation.Postoperative patient has a delicate constitution, and resists the virus attack ability and obviously reduces, and nutrition goods and materials such as a large amount of protein and VITAMIN also are badly in need of in wound healing.Protein content is repaired damaged tissue in the Chinese caterpillar fungus up to 27.81% pair, and recovering physique has tangible effect.

16, memory: contained nucleic acid bioactive ingredients in the Chinese caterpillar fungus, edible back is found, the increase of oxyphorase and oxygen affinity helps supplying with cerebral tissue, the cell oxygen carrying content increases, thereby eliminate the tired and raising ability of learning and memory that brain is not enough because of oxygen supply and shortage nutrition causes.According to another report, Japanology finds that nucleotide pair ischemia neurocyte has provide protection.The mouse brain cell mortality that found that diet Nucleotide is fewer.Experiment showed, edible nucleotide pair ischemia, neurocyte has provide protection, takes Nucleotide and shows in experimentation on animals and can prevention of brain block.

(2), hide the Radix Astragali and hide the Radix Astragali (Mikvetch), be the root of the leguminous plants Radix Astagali or the Radix Astragali.Warm in nature, the flavor sweet.Go into spleen, lung channel.Have effects such as invigorating QI to consolidate the body surface resistance, nourishing blood and promoting granulation, diuresis, holder poison.

Chemical Composition: mainly contain Radix Astragali triterpene soap class, polyose, saponin, flavones, 19 seed amino acids, compositions such as protein, trace element.

Pharmacological action in: 1, strengthening immunity: astragalus polysaccharides can obviously increase mouse spleen, the thymus gland quality, to spleen due to the loose dragon is arranged by force, the thymus gland quality alleviates that tangible antagonistic action is arranged.Can make T cell count increase in mouse thymus and the spleen in addition, promote the generation of 1gG.Can strengthen the activation of human lymphocyte Turnover of Mouse Peritoneal Macrophages and neutrophil leucocyte.Complement after ophiotoxin is handled is descended, and the cavy that phagocytic rate descends has the reparation of the complement of promotion, promote neutrophil cell raising and restore funcitons such as to engulf.Astragalus decoction can improve the regulating power of scavenger cell, T lymphocyte, bone-marrow-derived lymphocyte etc.And can obviously improve and specific immune function, humoral immunization, cellular immunization etc. is all had promote and enhancement that EVAC (Evacuation Network Computer Model) is had tangible hormesis, have and self induce, promote to induce and active volatilization.

2, anti-oxidant: the generation of oxyradical when Radix Astragali total flavones 10mg/kS can reduce the rat heart muscle ischemic.Radix Astragali total saponins 37.54g/ml adds the heart thigh that exsomatizes and preserves in the liquid, heart function and coronary flow are obviously strengthened. according to another report, flavones in the Radix Astragali has anti-radical action, and free radical is one of tumorigenesis disease factors such as mutagenesis, and the researchist falls the interior free yl level with flavones.Make its metabolism environment that destroys people's struma, reduce the accretion rate of tumour and suppress the swollen cell speed of growth.

3, delay senility: with A PS200mg/kg abdominal injection, mouse spleen is enlarged markedly, the increase of RND content reaches about 18%, can prolong cell survival, strengthens cellular metabolism, postpones aging.Astragalus polysaccharides has direct removing lipid peroxide (LPO), and SOD activity improving has good protective action to the rabbit aortic smooth muscle cells (SMC) of vitro culture because of the damage that free radical causes, the aging and effect such as sclerosis grade of control arteries.With fibrocyte in the human embryo lung (HEL) diploid of vitro culture is the experiment die body, measure cell survival, the strong ability SOD content of training, test group can be grown for 77 generations as a result, and control group was only lived for 52 generations, the same generation ability of cell proliferation in age, SOD content and generation survival time all are higher than control group.Astragalus polysaccharides can make in the old rats cell SOD contain obvious rising (150mg/kgP＜0.01) the anti-old and feeble effect of prolonging has been described.Astragalus polysaccharides can obviously reduce the reason that contains of lipid peroxide in the rat plasma, and the deposition of lipofuscin is to cause aging organ balance to be decreased a kind of factor, and it and age are linear increase sexual intercourse.

4, prevent and treat cardiovascular disorder: polysaccharide that extracts from Radix Astragali stem, leaf and saponin(e, through 17 of physiology, biochemical, morphology index consistent showing, to the heart of the Acute Myocardial Infarction dog myocardial contraction that changes, dwindle; Myocardial infarction area, alleviate effect such as myocardial damage, and can further cause the rabbit ventricle to reduce heart throughput rate reducing, reduce myocardial consumption of oxygen and protection ischemic myocardium.

5, improve sleep: astragaloside and water decoction irritate stomach or abdomen is annotated, and the mouse autonomic activities is reduced, and prolongs the lengths of one's sleep such as veronal, reduces fistfight.

6, bone density improving: decocting liquid 5g/kg gavaged the osteoporosis type rat to being caused by hydrocortisone in 60 days, can make the bone forming rate increase by 100%, the bone trabecula area increases by 37%, gavages in aqueous extract 5g/kgl2 week effectively to stop the bone loss of removal ovary rat.

7, antitumor: astragalus polysaccharides is to the human lung adenocarcinoma of knurl, liver cancer, nude mouse in the mouse, the strain of human colon carcinoma dehydration oncocyte knurl all has the obvious suppression effect, the inhibition ratio of outflow is 20%-51%, and to the mouse entity melanoma, effective tumour inhibiting rate of lung cancer is 20%--47%.According to another report, Radix Astragali water extract 100g/ml reaches 94.94%. to the inhibiting rate of human stomach cancer cell line AGS

8, skin makeup: the Radix Astragali can strengthen skin-nourishing and skin antibacterial ability, prevents skin aging, promotes hair growth, and is anti-loss.Contain the trace element of multiple amino acids and needed by human etc.Effect with skin nutrition promotes skin metabolism, improves skin resistance, makes skin delicacy, fitness.

9, control is dull-witted: it is reported, Japanology studies show that, the researchist raises the animal suffer from senile dementia with Radix Astragali extract, found that and can significantly improve its cognitive ability, gives patients of senile dementia the oral obvious effects that obtained the capsule of heavy dose again subsequently.Studies show that this natural drug truly has smelting to treat the effect of degeneration cerebral diseased.

10, the metabolic influence of pair cell.The Radix Astragali can obviously delay human embryonic lung diploid fibroblast naturally-aged process, can prolong cell survival about 1/3; Healthy human lymphocyte silk division has restraining effect to vitro culture in high density, and promoter action is then arranged during lower concentration.

11, to the influence of nucleic acid metabolism.Astragalus polysaccharides has the effect of antagonism mercurial, and the ribonic acid enzyme of body and supressor equilibrium system thereof are kept normally; To mouse peritoneal injection 200mg/kg the effect of remarkable inhibition liver, spleen alkalescence Yeast Nucleic Acid enzyme activity is arranged, but serum and acid core ribonuclease T. are not had obvious effect.

12, to proteinic influence.Astragalus decoction continuous irrigation stomach 10 days can significantly increase the speed that the 3H-leucine mixes serum, hepatic protein, and Protein content not had influence, thinks that the Radix Astragali can promote the renewal of mice serum and hepatic protein, and effective constituent may be polysaccharide; And astragalus saponin 1 also has similar effect.

13, anti-mutation.Astragalus decoction raises significant inhibitory effect is arranged the lie prone bone marrow cell micronucleus permillage of the mouse active somatic cell that brings out and chromosome aberration percentage of flavacin, and along with increasing of dosage, more remarkable effect is situated between and also not exclusively suppresses the mutagenesis that flavacin is lain prone.The mechanism of action of Radix Astragali anti-mutation in living animal may be protected cell with its effective constituent, and raise immunity and promotion DNA are synthetic, and the injury repairing effect of strengthening DNA is relevant.

14, beauty treatment.The main component of the Radix Astragali (be divided into polysaccharide, the liquor-saturated alcohol of-paddy steroid, trace element and choline, folic acid etc. though the merit of tonifying Qi is inferior to genseng, are sent out because of its this property of medicine is kind, walk table flesh, can be better with the Radix Astragali in beauty treatment side.Modern study shows that the Radix Astragali has enhancing and adds effects such as promoting organism metabolism.

15, to the influence of blood system.Astragalus decoction causes the pressure drop of hemolytic deficiency of blood zooblast low to this hydrazine of acetyl, and the blood specific viscosity reduces, and the erythrocyte electrophoresis rate reduces, and electrophoresis time prolongation etc. all has the improvement effect.It is hemopoietic function that the Radix Astragali injection abdominal injection can strengthen the normal mouse grain, and making the single grain of marrow is that the progenitor cell number is apparently higher than control group; Caused by cyclophosphamide rat marrow hemopoietic function there is obvious provide protection unusually, can stops the obvious minimizing of bone marrow nucleated cell number.Hairy Root of Astragalus membranaceus gavages, can improve RBC number, the reticulocyte counts of hemorrhagic anemia mouse, increase RBC number, oxyphorase value, the pcv value of hemolytic anemia mouse, can resist the decline of the leukocyte count and the bone marrow nucleated cell number of endoxan, X ray induced mice, the effect that promotes the hemopoietic system function is arranged.

16, protect kidney: the Radix Astragali injection intravenous injection can make the serum albumin of rat MCN model obviously raise and can increase the blood fortune of glomerular capillary silk; To rabbit mesentery productive nephritis, can obviously reduce glomerular mesangium district IgG and C3 deposition.The Radix Astragali can significantly reduce proteic amount in the urine, alleviates the renal lesions degree.The mechanism of Radix Astragali treatment nephrotic syndrome improves seralbumin concentration, thereby improves its clinical manifestation for promoting to suffer from the protein synthesis of body.

17, diuresis.The Radix Astragali has medium diuretic properties, human trial declines bright, this product can increase the urine amount and oxide compound is drained, give clinical dosage urine amount o.2g/kg and can increase by 64%, the diuretic properties time length of row's sodium amount increase 14.5%. Radix Astragali is longer, after giving rat skin lower injection, the generation that has no drug resistance after 7 days of sustainable 7 days of diuretic properties, successive administration.

18, antifatigue, astragalus polysaccharides 250-500mg/kg abdominal injection, but the * deficiency of yang due to significant prolongation normal mouse and the hydrocortisone // mouse normal temperature swimming time, and increase mouse suprarenal gland weight under the stress situation.

19, anti-hypoxia.Radix Astragali oral liquid 20～50g/kg irritates stomach, astragalus polysaccharides 280～500mg/kg abdominal injection all has remarkable antagonistic action to the mouse normal pressure of normal and Racemic isoproterenol processing and the cerebral anoxia due to decompression anoxic, cyanide poisoning anoxic and the ligation bilateral carotid, and can obviously prolong mouse has live time.

20, cold-resistant.The astragalus polysaccharides abdominal injection can obviously strengthen low temperature resistant (5 ℃) ability that normal mouse, hungry mouse and oxidation cortisone are handled mouse, and its survival time is obviously prolonged, but does not have obviously high temperature resistant (45 ℃) effect.

21, radioprotective.Astragalus polysaccharides can impel the spleen tissue structure of the mouse damage behind the radiation exposure obviously to recover, and improves the super emblem structure of spleen endolymph cell, improves the activity of succinodehydrogenase in the peripheral blood lymphocyte.And mouse weight loss, leukocyte count due to right-60 ℃ of irradiations fall now with the Ultrastructural change of liver obvious provide protection are all arranged.

22, antiviral. astragalus decoction has direct inactivation of viruses effect, and can suppress the cytopathy behind the infective virus, can directly suppress varicella one varicella zoster virus, and the virus of duplicating is had the growth-inhibiting effect.Radix Astragali injection has certain blocking effect to the course of infection of epidemic haemorrhagic fever virus in the mouse suckling mouse body according to another report.The Radix Astragali has antivirus action or has the function that protection myocardial cell rabbit is subjected to the virus infringement, and the experiment in vitro Radix Astragali comprises virus of AIDS quite under the concentration inhibition virus function being arranged.

23, analgesia.Mouse writhing method and hot plate method experiment show that astragalus saponin 1 and sheep Astragaloside have obvious analgesic activity.

24, increasing intelligence. Radix Astragali decocting liquid drinks or irritates stomach to mouse, the effect of strengthening learning and memory of little mouse is arranged, and helps the storage of mouse brain to information.

25, antibiotic.To dysentery bacterium, anthrax bacillus, a-Streptococcus hemolyticus, p-Streptococcus hemolyticus, diphtheria corynebacterium, bacillus pseudodiphthericus, pneumococcus, streptococcus aureus, Staphylococcus citreus, Staphylococcus albus and Bacillus subtilus etc. have anti-microbial effect to the Radix Astragali external.

26, anti-inflammatory.Astragalus saponin 1 irritates stomach or 5mg/kg intravenous injection for rat 50mg/kg all can be increased the rat capillary permeability that antihistamine and serotonin cause.25～100mg/kg irritates stomach, can significantly resist the rat paw edema that carrageenin causes, its inhibiting rate is linear in this dosage range.

27, hormone-like effect.Radix Astragali extractum, Radix Astragali lactone and Radix Astragali sterol are to rat. and weight such as the body weight of mouse, levator ani or kidney all do not have obvious influence, showing no anabolic hormone or the effect of male hormone sample. the Radix Astragali can make mouse obviously continue 10 oestrus, and estrogenic promoting action is arranged.Water extraction of astragalus membranaceus can suppress the bone resorption of removal ovary rat, has function of resisting osteoporosis.

28, vasodilation: modern pharmacological research shows that Radix Astragali extract has the effect of vasodilation coronary artery and whole body peripheral vessel.

(3), hide matrimony vine (LyciUm barbarnm extraat), wolfberry fruit is the sub-mature fruit of matrimony vine of solanaceae plant.The property flat, flavor is sweet.Have by the liver kidney, promoting generation of vital essence and blood makes eye bright, moistening lung, beauty treatment, functions such as fat-reducing.

Chemical ingredients: the wolfberry fruit main component has polysaccharide, amino acid, sweet theophylline, carotene, VITMAIN B1, Wei ShengsuB2, various trace elements such as multivitamin such as vitamins C, nicotinic acid and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalt, iron.

Pharmacological action: 1, protection birth-death system it is reported research of HSPH of Wuhan University

Achievement shows that lycium barbarum polysaccharide can produce provide protection to the reproductive system that is damaged by effect " hypothalamic-pituitary-gonadal " this axis.

Experiment shows that lycium barbarum polysaccharide promotes hypophysis secretion gonadal hormone by the gonadotropin effect, and " hypothalamic-pituitary-gonadal " this axis is produced the multilayer regulating effect, impels the production of sperm process unimpeded normal with the growth of testis sexual cell.

2, sexual function improving: wolfberry fruit has invigorating the liver and kidney, promoting generation of vital essence and blood, supporing yang function.No matter be that insufficiency of kidney-YANG, deficiency of the kidney yin all have certain effect, wolfberry fruit extract also has the effect of short gonad function, and plasma testosterone level is significantly raise, and property kinetic energy is gone down, and impotence plays an important role.

3, strengthening immunity: wolfberry fruit is a medicine-food two-purpose food, and the wolfberry fruit polysaccharide has strengthening immunity, and antitumor action can strengthen the cell anti-cancer function selectively.Lycium barbarum polysaccharide can strengthen natural killer cell and lymphocyte vigor, promotes interleukin to generate, and strengthens monocytic immune vigor.The wolfberry fruit polysaccharide also has antimutagenic effect, when mutagenesis produces genetic damage and cell mutation, can repair damaged cell and recover its normal function.

4, anti-ageing: wolfberry fruit has the rejuvenation effect, and showing as to stimulate sexual gland and internal secretion, strengthens hormonal secretion, strengthens the physiological function of brain function and neurocyte.The toxin phenomenon occurs accumulating in the blood though can avoid people's age growth, thereby keep the normal function of in-vivo tissue.But wolfberry fruit polysaccharide antagonism free radical peroxidase activity strengthen superoxide-dismutase and glutathione peroxidase vigor, thereby the damage that alleviates the radical pair body has anti-ageing effect.

5, the plant of a kind of indomitable vitality of wolfberry fruit, the traditional Chinese medical science think that taking wolfberry fruit can help human body to strengthen energy, nourishing liver and kidney, replenishing vital essence to improve eyesight, the increase immunizing power that nourishes blood, and the effect that wolfberry fruit adapts to most is exactly an antifatigue.Antifatigue: matrimony vine can be improved oxyproline concentration, thereby improves muscular strength, and fatigue capability is strengthened.

6, protection liver: wolfberry fruit extract has certain effect to protecting liver and fatty liver.Reason is that matrimony vine contains a kind of effective constituent one sweet theophylline, and it is effective to the treatment liver.Pharmacological research shows that sweet theophylline has the fat of inhibition to deposit, and promotes the effect of liver cell regeneration in liver cell.Concerning the liver patient, the sweet theophylline in the wolfberry fruit can prevent that fattiness stores in the liver, and lipotropic effect is arranged, and contained chlorophyll helps the liver detoxification effect in the matrimony vine, can also increase and improve liver function simultaneously.Chronic hepatitis patients, especially fatty liver patient.

7, reducing blood-fat: wolfberry fruit extract can reduce the rat cholesterol, and the cholesterol that can obviously suppress hypercholesterolemia and the caused rabbit anteserum of lard feed increases.

8, hypoglycemic: wolfberry fruit extract can reduce rat blood sugar significantly enduringly, improves sugar tolerance.

9, control age-related macular degeneration: wolfberry fruit has the easypro liver effect that makes eye bright.To chronic hepatitis, central serous chorioretinopathy, optic atrophies etc. are evident in efficacy.Ageing disorders such as old organ senescence had very strong improvement effect.Discover that wolfberry fruit helps to reduce the generation of old degeneration maculopathy.

10, anti-apoptotic: apoptosis is called apoptosis again.Pertinent data shows that brain normally has 10 nerve cell deaths every day approximately, and the human body new neurocyte of can not regenerating.When the fast a large amount of apoptosis of cell, early ageing, weak, film attenuation and atrophy can appear in the people, skin kraurosis, and with a haggard face, memory and thinking ability descend, even it is slow-witted old disease to occur.

Apoptosis except with occur outside the Pass pathology and inherited genetic factors have, a large amount of apoptosis fast and two factors are closely-related; First free radical is made the oxidizing reaction of use free radical with old and feeble closely related, causes that the free radical of cellular oxidation all can cause apoptosis.Studies confirm that, " cerebroside ester, " that wolfberry fruit contains is that oligose combines formed glycosides with the ceramide terminal hydroxyl, owing to cerebroside ester is combined into by hydrophilic glycosyl and lipophilic ceramide, be one of important component of cytolemma, can keep cyto-architectural integrity.Simultaneously, cerebroside ester can form hydrogen bond network widely in microbial film polarity and nonpolar interface.This is to constitute the constitutionally stable important factor of microbial film stratiform.

According to another report, Ca2+ extensively raises in the LBP DEX inductive capable of blocking thymocyte, suppresses DEX inductive dna segmentization, and restraining effect has dose-dependently, its mechanism of action may pass through to reduce the wide concentration of cell C for LBP, suppresses the endonuclease enzyme activation, thus the blocking-up apoptosis.

11, antitumor: the lycium barbarum polysaccharide combination with radiotherapeutic has certain radiosensitizing effect to acute weary oxygen tumour cell.Lycium barbarum polysaccharide has in the non-specific antitumor and specificity antineoplastic process scavenger cell certain activation is all arranged.With S180 lotus knurl Bal6/C mouse is model, discover, lycium barbarum polysaccharide can recover and improve mice with tumor spleens cell number and activating T cell multiplication capacity, promotes the active and TNF secretion level of NK, and the prompting lycium barbarum polysaccharide can strengthen cellular immune function makes it suppress the dominant mechanism of tumor effect.

12, beauty treatment is preserved youthful looks: so the anti-ageing lipid that can suppress deposits in liver cell, promote liver cell new life's effect.Matrimony vine contains carotene, and compositions such as VitB1, riboflavin, Yan acid have moist skin, and the look of preserving youthful looks is the good merchantable brand of beauty treatment.Wolfberry fruit can improve the ability to take oxygen of skin, can play the effect of skin whitening.

It is reported that Britain, French medical science man discover that wolfberry fruit contains a kind of VITAMIN of not meeting, and is named as " VITAMIN ", is also referred to as the VITAMIN of preserving youthful looks.So wolfberry fruit extract has extremely strong skin maintenance effect.

(4), hide cynomorium songaricum (HerbaCynmor), be the parasitic Cynomoriaceae plant drying of perennial meat sliced meat stems. warm in nature, flavor is sweet.Return spleen, kidney, large intestine channel.Have tonify the kidney and support yang, benefiting essence-blood, ease constipation road just, clinical impotence, the soreness of the waist and knees of being used for, the dry constipation of intestines, antifatigue, effects such as hypoxia tolerance.

Chemistry success: mainly contain triterpene substance: cynomorium songaricum terpene, ursolic acid, acetyl ursolic acid, volatile oil, palmitinic acid, Sitosterolum, daucosterol, catechin, former catechin, amino acid, inorganic elements.

Pharmacological action: 1, strengthening immunity; Cynomorium songaricum alcohol extract 0.5g/kg mouse stomach can improve the ability of engulfing chicken red blood cell after 7 days; Can strengthen the empty class of mouse spleen haemolysis number in 2g/kgl0 days; Give deficiency of yang mouse gavaging 2g/kg7 days, can propose the conversion of product spleen lymphocyte and draw energy.The mouse gavaging water extract can increase the heavy and neutrophil leucocyte number of mice spleen in 10g/kgl9 days, increased the mice serum grain and counted hemolysin and hemagglutinin value, had the promotion humoral immune function.

2, anti-oxidant: experiment shows in the body, and Herba Cynomorii extract can stop ethanol to reduce the active and assorted high LPO of SOD.Experiment in vitro shows the effect that can directly remove hydroxy radical qiao.In addition gavage mouse, hypoxia tolerance, antifatigue, high temperature resistance, stress ability such as cold-resistant are arranged with water decoction.

3, strengthen endocrine function: cynomorium songaricum alcohol extract 2g/kg give childhood rat oral gavage 15 days, can significantly increase the testosterone concentration in the male juvenile mouse blood plasma.Testosterone can promote cell growth, differentiation, maturation, and strengthen muscle and the sick and wounded recovery of acceleration all exist in the masculinity and femininity body.It is reported: water decoction 10g/kg irritated stomach 9 days for male deficiency of yang mouse (intramuscular injection hydrocortisone), and the concentration of the serum glucocorticosteroid that can obviously raise makes it to return to normal level.The cynomorium songaricum water extract can make hypothalamus-hypophysis, and-adrenal cortex axle is suppressed the mice serum hydrocortisone and obviously raises.

4, antifatigue: the cynomorium songaricum water decoction is given mouse stomach, and the mouse swimming time is prolonged, and the assorted high-amplitude of serum creatine kinase reduces behind the load exercise, the general hyperplasia of motion back plastosome, loose not damaged, explanation can realize its antifatigue effect on constitutional basis.Promote the animality maturation: test shows that Herba Cynomorii extract has the sophisticated effect of the animality of promotion, also can resist the mouse sexual behaviour that factor such as long-term anxiety causes and reduce.

5, hypoxia tolerance, experimental result shows, the cynomorium songaricum water decoction gavages can the significant prolongation survival time of mouse under anoxic condition, has apparent normal pressure resisting oxygen lack, and cynomorium songaricum polysaccharide, total glucoside and total steroidal class all can prolong mouse normal pressure hypoxia tolerance, ISO increases oxygen consumption and causes the anoxic survival time; Make the prolonged survival period of mouse mainline air.

6, improve brain function: feed cynomorium songaricum after 45 days, can improve the decline of dementia rat model memory, make by labyrinth time shortening 39.74%, prominent axle caudacoria dense matter thickness obviously increases.

7, remove free radical: methods such as employing ESR show the removing free radical effect experimental result of cynomorium songaricum, cynomorium songaricum can stop in vivo that serum that liquor damage causes and Intramitochondrial superoxide dismutase are active to be reduced and lipid peroxide raises, and prove that cynomorium songaricum contains the removing free radical is had tangible action component.

8, relax bowel: experiment shows that cynomorium songaricum solution is the excited intestinal tube of energy under finite concentration, increases intestinal peristalsis, has functions of loosening bowel relieving constipation.The mechanism that cynomorium songaricum relaxes bowel forms known saline cathartic such as Na2 with the water-soluble inorganic ion that contains in the intestinal mucosa, Mg SO4, Na3 (PO) etc. are relevant.

9, anti-gastric-ulcer: the cynomorium songaricum decoction that experiment showed, subcutaneous injection or oral DCS50% all has significant antiulcer action.The antiulcer action of DCS is relevant with PGE2 content increase in the gastric mucosa, and PGE2 can gastric acid inhibitory secretion and anti-gastric-ulcer effect.

10, antitumor: cynomorium songaricum all has restraining effect to reversed transcriptive enzyme (RT) and people DAD polysaccharase a, has report to think that the oleic acid that cynomorium songaricum contains has the control function of tumor.

11, platelet aggregation-against: cynomorium songaricum total reducing sugar, total glucoside, total steroidal class all show as restraining effect to adenosine diphosphate (ADP) inductive rat platelet aggregation.And be good dose-effect relationship.

(5), hide sealwort (Huang jing), for my year living Liliaceae is planted the dry rhizome of taxi.The property do, flavor is sweet, return spleen, lung, kidney are strong.Effect with tonifying spleen yin-nourishing, invigorating the spleen moistening lung, kidney tonifying.Be used for empty weak, the mouthfeel food of weakness of the spleen and the stomach, body less, the dry larynx of the deficiency syndrome of the lung.Be longer than invigorating the spleen and replenishing QI, benefit support taste, sick body void, weakness of the spleen and the stomach, dry food less, asthenia of essence and blood.Compendium of Material Medica record: sealwort benefit controlled atmosphere essence, gentle, the muscle sufficiency of the five internal organs.Have not old for many years, the blackening of turning white, dedentition and give birth to effect.Modern pharmacological research, sealwort can effectively hypotensively can increase the symptom blood flow volume completely with blood sugar, plays blood fat reducing and delays arteriosclerotic effect.

Chemical ingredients: mainly contain polygonatum polysaccharide class, steroid saponin, flavones, multiple amino acids, alkaloid, N.F,USP MANNITOL, lymphatic temperament, flower quinones etc.

Pharmacological action: 1, improve immunizing power: discover that sealwort has the effect that strengthens the human T cell.Immune function of human body be can strengthen, DNA, RNA and proteinic synthetic promoted.Lymphocyte transformation to the immunologic hypofunction patient has excitation.Compound can make mouse chest arteries and veins weight show to be increased, and can improve the humoral immunity level of thin chest sum of animal splenic T and external source thymus-dependent antigen, strengthens cellular immune function.Mouse is wrongly taken coarse solomon's seal polysaccharide 400mg/kg, and 7, can obviously strengthen thymus gland and spleen weight after day, obviously strengthen wind shape endothelium and do not unite the phagocytic activity of india ink.

2, anti-oxidant: sealwort can be caught high free radical ability.The sealwort decoction can obviously improve the content that superoxide dismutase activity in mouse red blood cell and the liver reduces cured brown matter in mouse cardiac muscle and the cerebral tissue.The sealwort oral liquid can significantly reduce the heart, liver lipid oxidation thing (LPO) generates, and increases superoxide-dismutase, and the paddy Guang is peptide peroxidase (GSH-P) vigor and the super oxidation synthase of blood vigor.Show that sealwort can obviously improve body Green Tea Extract ability, to suppressing the effect that LPO generates the tool uniqueness.Coarse solomon's seal polysaccharide can reduce the carbon tetrachloride poisoning Mouse Liver: mda content in the tissue has anti-matter and refers to peroxidation.

3, anti-ageing: wrongly took decoction 27 days to mouse, can obviously reduce myocardium lipofuscin content and improve the liver SOD activity, the lipid peroxidation that the protection free radical causes has anti-aging effects to the infringement that biofilm structure and function cause.Wrongly take sealwort 6g/kg to mouse, the activity of 10 days red corpuscle Na+ that can raise, K+-ATP enzyme.Polygonatum polysaccharide promotes mouse lymphocyte transformation efficiency, red corpuscle, crystal nuclear, lens cortex superoxide-dismutase SOD activity.Water decoction 2.59g/kgd, 3g/kgd can make skin hydroxyl dried meat aminoacids content increase by 6.6% in 1 month for the mouse gastric lavage, significantly improved lactate dehydrogenase activity and brain homogenate catalase activity in cardiac muscle and the cerebral tissue, can obviously improve the mouse hypoxia-bearing capability.The telomerase activation of old and feeble rat brain, the gonadal tissue of can significantly raising.

4, antipathogen: experiment in vitro shows that the sealwort water decoction is to Corynebacterium diphtheriae, and golden yellow or the like coccus, acid-fast bacilli and adenovirus and cancer virus have restraining effect.Tuberculosis is had notable therapeutic effect, and curative effect is carried nearly vazadrine.In addition multiple fungi also there is restraining effect.

5, improve adrenal cortex function: sealwort has the effect that suppresses adrenal cortex function, and caused fat, neat random the having some improvement of carbohydrate metabolism are advanced by adrenal cortex unit.

6, protection liver: coarse solomon's seal polysaccharide can obviously reduce the mda content in the CCl4 poisoning mice hepatic tissue, has lipoid peroxidization resistant.

7, antifatigue: the sealwort water decoction is wrongly taken mouse and is carried out the swimming test result and show, mouse prolongs at the frozen water swimming time, can strong mouse muscle power and to stressed condition down opposing can, have remarkable antifatigue effect, it is relevant that the many low thighs of this effect cause kinases (CK).Sealwort also has good anti-tubercle bacillus to do in addition, thereby is fabulous help anti-fatigue product.

8, anti-hypoxia: experiment shows, the sealwort water decoction is wrongly taken and can be improved mouse and survive under anoxia condition and utilize ability, to increase often anti-sound when scarce.Significantly improve lactate dehydrogenase activity and brain homogenate catalase activity in cardiac muscle and the cerebral tissue, can obviously improve the mouse hypoxia-bearing capability.

9, radioprotective: polygonatum polysaccharide can obviously resist the minimizing of 6 ℃ of gamma ray induced mice peripheral leukocytes and total number of blood platelet, can obviously improve irradiation mouse peripheral red blood cells C3b receptor rosette rate and immunocomplex rosette rate.

10, coronary artery dilating, anti-scheming ischemic: experiment showed, that sealwort can make rat heart thigh convergent force obviously strengthen, the coronary disease mistake flow that exsomatizes is obviously increased.Intravenous injection have the antagonism Pituitrin due to the effect of acute heart thigh ischemic.

11, anti-oligoleukocythemia: polygonatum polysaccharide can the cruel amine of bright antagonism ring phosphorus institute reduce to locating the mouse peripheral blood leucocyte, the mouse spleen weight of immunocompromised is increased, its leukogenic effect may be the hyperplasia by the spleen mesenchymal cell, and performance compensatory marrow is made its function outward.

12, reducing blood-fat: exempt to take 100% decoction 10ml/d to hyperlipidemia, 30 days, can obviously reduce trigalloyl oil-beta lipoprotein, cholesterol (TC), alleviate aorta wall patch and crown arteriosclerosis.Exempt to take polygonatum polysaccharide 1.6ml/gkd to hyperlipemia, can obviously reduce serum LDL-C, LP (a), TC concentration and minimizing, the aortic tunica intima foam cell forms.

13, hypoglycemic: polygonatum polysaccharide 500/kg, can significantly reduce suprarenin, model mice blood sugar and liver CAMP content.Medicinal extract and methanol extract can suppress the glycogen alcoholysis, to suprarenal gland, chain urea toxin bring out blood sugar increasing mouse, exempt from that the obvious functions of blood sugar effect is all arranged.

14, tuberculosis: water decoction is external to have the obvious suppression effect to tubercule bacillus.

(6), Tibetan medicine Root of Kirilow Rhodiola (HONgingtian), the Tibetan medicine Root of Kirilow Rhodiola be grown in the high and cold anoxic in 3500 meters-5000m Qinghai-Tibet Plateans, drying, ultraviolet ray is strong, day and night temperature is big, the wild plant of extreme natural environment.The Tibetan medicine rhodiola is in the herb of Crassulaceae plant Root of Kirilow Rhodiola, and is cold in nature, flavor is sweet, puckery, has effects such as promoting blood circulation and removing blood stasis, removing heat from the lung to relieve cough.Tibetan medicine's " brilliant strain book on Chinese herbal medicine " puts down in writing it foster lung, heat-clearing, invigorating premordial QI, go effects such as halitosis.Tibetan is referred to as " plateau genseng ".That modern medicine study is widely used in is anti-ageing, regulate immunologic function, cardiac stimulant antifatigue, hypoxia tolerance, radioprotective, raising is mental and specific functions such as physical function, anti-peroxidation.As treat high altitude anoxia and HAHD etc.Tibetan are used for the treatment of spitting of blood, haematemesis, pneumonia, cough and women's diseases such as leukorrhea often.In recent years China discovers, and is the rarest in the known tonic of the pharmacological action of safranine red-spotted stonecrop.Immunization is better than genseng, and without any side effects.The seventies in 20th century, USSR (Union of Soviet Socialist Republics) studies have shown that, Root of Kirilow Rhodiola have the similar traditional Chinese medical science " strengthen the body resistance to consolidate the constitution " have " adaptation former state " effect.According to foreign literature, clinical application shows that Radix Rhodiolae has moist strong, and old heart failure and impotence are had therapeutic action, improves muscle power and brainwork function.The powder of rhizome or medicinal extract are used for diabetes, pulmonary tuberculosis and anaemia, and neuropathy and ypotension are also had effect.

Chemical Composition: mainly contain rhodioloside and Jujubogenin tyrosol, protein, fat, 19 seed amino acids, alkaloid, flavonoid compound, phenolic compound, bioactive trace elements, compositions such as iron, zinc, cobalt, copper, manganese.

Pharmacology is done: 1, regulate immunizing power: China discovers in recent years, and the pharmacological action of Root of Kirilow Rhodiola is rare, and immune strong function is better than genseng.Root of Kirilow Rhodiola can be transferred the human body self immunologic function, and the interior environment of human body imbalance is corrected, and qi and blood is able to unimpeded, thus the natural anti-ability of unloading of exciting human, the slack state of change organ.

2, regulate heart function, anti-cardiac muscle aging: rhodioloside and ketone all can significantly reduce the rat left ventricular end diastolic at short notice and press (LYEDP) and femoral artery mean pressure (BP).Illustrate that rhodioloside and ketone all can reduce heart front and back load, change heart function.The Root of Kirilow Rhodiola decoction can make the isolated frog heart shrinkage amplitude increase by 30%, gives at the subcutaneous lymph injection of body frog rhodioloside, can make the heart contraction amplitude increase by 128.6%.Rhodiola essence can obviously increase the SOD in rat blood serum and the cardiac muscle, obviously reduces LPO, and rat heart muscle superstructure aging phenomenon is obviously alleviated, and prevention is arranged and delay the old and feeble effect of cardiac muscle.According to another external report, Root of Kirilow Rhodiola has the strengthening by means of tonics effect, and old heart failure is had smelting treatment effect.

3, anti-arrhythmia: the rhodioloside rat rhythm of the heart that can slow down, have stronger anti-oxidant barium and bring out the rat ventricular effect, the tachycardia of its generation there is stronger role of correcting.

4, protection cardiac muscle: rhodioloside can reduce mouse under the situation of severe depletion of oxygen; the lactic acid content of brain and cardiac muscle; cardiac muscle cyclic monophosphate/cyclic guanosine monophosphate ratio when recovering anoxic has protection heart muscle capillary endotheliocyte, the effect that alleviates injury of mitochondria.Compositions such as Root of Kirilow Rhodiola general glycoside can protect rat, neonatal rat myocardial cell to cultivate scarce sugared hypoxic damage, reduce the release of serum lactic dehydrogenase when giving oxygen injury again.

5, anti-oxidant: rhodioloside can show the concentration that reduces the liver Serum LPO, has stronger anti-finger matter peroxide and turns into.Root of Kirilow Rhodiola decoction and tyrosol can suppress rat liver homogenate endoperoxides lipid at experiment in vitro and generate.Tyrosol also has restraining effect to rat brain and the generation of heart homogenate endoperoxides lipid.Can suppress mice serum endoperoxides lipid to the mouse multiple dosing and generate, the generation of the superoxide in mouse brain, the heart and the liver is also had the obvious suppression effect.

6, anti-ageing: rhodiola essence can prolong going down to posterity the life-span of 2BS cell, promotes growth and proliferation of cell, strengthens liver Adenosine Triphosphate enzyme (ATP-ase) and reduces acid phosphatase (ACO-ase) activity, promotes DNA synthetic, improves macrophage phagocytic function.

7, antifatigue: the Root of Kirilow Rhodiola decoction can the swimming time of significant prolongation mouse in frozen water.Radix Rhodiolae extract and rhodioloside can prolong the mouse swimming with a load attached to the body time.Radix Rhodiolae extract can prolong mouse and grab rod to the tired time, and the mouse subcutaneous injection rhodioloside also can strengthen the mouse anti-reflecting fatigue function.

8, hypoxia tolerance: the experiment of mouse hypoxia tolerance shows that oral Root of Kirilow Rhodiola alcohol medicinal extract (RKEE) can improve cerebral tissue to anoxybiotic endurance, prolongs the survival time, and the cerebral anoxia process is had the improvement effect, can strengthen the oxygen tension of cerebral tissue.

9, high temperature resistance: mouse is irritated stomach Root of Kirilow Rhodiola decocting liquid 10g/kg every day, can obviously improve the mouse anti high temperature capabilities.

10, promoting blood circulation and removing blood stasis: as to it is reported: utilize double-blind method that Root of Kirilow Rhodiola treatment plateau cytosis is carried out observation of curative effect, the result shows that Root of Kirilow Rhodiola has certain function of promoting blood circulation to disperse blood clots.

11, endocrine regulation: Root of Kirilow Rhodiola can excite nerve system and bring into play endocrine regulating effect.Studies show that Root of Kirilow Rhodiola has extremely strong regulating effect to endocrine system, especially endocrine system is had tangible opsonization, women's gynaecopathia is had fine booster action.Mechanism is to strengthen Tiroidina, suprarenal gland skin etc. and ovarian function.

12, improve muscle power and activation central nervous system: modern study finds that Root of Kirilow Rhodiola has crucial meaning as several environmental adaptation medicines in military affairs, medical science, aerospace medicine.Can be used as all and be in the good medicine that the staff in the undesired environment builds up resistance, it all has tangible double-bang firecracker regulating effect to improving muscle power and brainwork efficient, is the ideal tonic.It is reported that foreign study finds that Root of Kirilow Rhodiola can activate nerve and antifatigue.Behind the oral Root of Kirilow Rhodiola of the former person of will, memory is improved in a short time, attention is concentrated, the tired improvement, shows that Root of Kirilow Rhodiola truly has brain tonic, improves the effect of memory.Not it is reported that USSR (Union of Soviet Socialist Republics) is used for cosmonaut's health care and antisecosis to the mysterious rhodiola root of natural plant of northwest Leah extremely frigid zones, its effect is fairly obvious.1976 with Root of Kirilow Rhodiola with being to adapt to the former state medicine, be widely used in cosmonaut, pilot, frogman etc.It is also regarded as wuwa by kremlin.

13, improve sleep: the Root of Kirilow Rhodiola decoction can obviously strengthen the Thiopental Sodium syngignoscism, the convulsions effect of antagonism caffeine sodium benzoate.Rhodioloside can significantly shorten the sagatal time for falling asleep and prolong its length of one's sleep.

14, dual regulation: remote measurement animal brain electric wave is observed and is shown, use Root of Kirilow Rhodiola can make drug-induced excitatory or inhibition type brain wave recover normal, environmental factors makes the organism physiology variation no matter to that aspect development, uses Root of Kirilow Rhodiola can make it recover normal level.

15, anti-inflammatory: can significantly suppress rat paw edema due to the dextrorotation powder liver for rats by intraperitoneal injection Root of Kirilow Rhodiola water decoction 0.5,1.0/kg.Subcutaneous injection rhodioloside 10mg/kg, the leukocytosis that can prevent subcutaneous injection turps to cause.

16, toxinicide: Root of Kirilow Rhodiola can improve the survival rate after mouse poisons, and the antagonism Toxoid,tetanus waits various bacteriosis elements, improves the immunological effect of brucella vaccine.

17, antiviral: the Radix Rhodiolae polysaccharide can stop the adsorption of virus at host cell effectively, and the reproduction process in host cell has restraining effect to virus simultaneously.The human amniotic cell that Radix Rhodiolae tyrosol (RABT) add to be cultivated to the attack of being afraid of Sa Qi B5 virus have certain resistant function in, mechanism may be RABT and virus some acceptor site on the competition cell film simultaneously, thereby stops or disturbed viral absorption or link such as penetrated.

18, promote ATP synthetic: Root of Kirilow Rhodiola medicinal extract can improve the rna content of skeletal muscle, promotes the ATP resynthesis, improves the muscle power and the brainwork efficient of human body.Root of Kirilow Rhodiola also has hypotensive and hypoglycemic activity in addition.

(7), ZANGDANGGUI (Amgelica), when the loose root that is classified as the perennial herb samphire.

Warm in nature, flavor is sweet puts down, has that blood circulation promoting and enriching, menstruation regulating are moisturized, the function of ease constipation.Functions such as brain tonic, protection liver, constipation.

Chemical ingredients: mainly contain volatile oil, linolic acid, nicotinic acid, vitamins B ₁₂, polysaccharide, β-paddy stay compositions such as alcohol.

Pharmacological action: 1, strengthening immunity: Radix Angelicae Sinensis and Radix Angelicae Sinensis polysaccharide (AIP) are to non-specific immune function, cellular immune function, and humoral immune reaction and cytokine all have significant promoter action.The body that immunologic function is in holddown also has adjusting and restitution.

2, improve anaemia: Radix Angelicae Sinensis aqueous extract, Radix Angelicae Sinensis polysaccharide all can significantly promote the generation of oxyphorase, red corpuscle, white corpuscle and marrow karyocyte.This act on that peripheral blood cells reduces and marrow particularly evident when being suppressed.As giving the mouse abdomen injection stupid hydrazine of Radix Angelicae Sinensis polysaccharide or 60 ℃ of irradiations in advance, the recovery of mouse hemopoietic function all there is significant promoter action.Chinese angelica oral liquid has tangible anti-anaemia effect, and vitro culture also proves that Radix Angelicae Sinensis polysaccharide has the anemia mice of stimulation granulocyte, the effect of monosystem progenitor cell (CFU-GM) propagation.

3, protection liver: the Radix Angelicae Sinensis water decoction has provide protection to chmice acute CCL4 toxic hepatitis.And prevent that liver starch from reducing; With the Chinese Angelica Root forage feed mouse that contains 5% the liver oxygen-consumption is increased, it is stable that liver starch keeps.According to another report, the forulic acid that contains of Radix Angelicae Sinensis has provide protection to liver injury.Experiment shows that the Sodium Ferulate steel is the antagonism bromobenzene effectively, paracetamol, and number of chemical liver damages such as ethanol, and to hepatic ischemia, reperfusion injury and immunological liver injury have provide protection.

4, beauty treatment: Radix Angelicae Sinensis contains a large amount of volatile oil, VITAMIN, organic acid and trace element, waits multiple organic component, and experimental study shows that Radix Angelicae Sinensis can be expanded peripheral blood vessel, reduces vascular resistance, increases blood circulation amount etc.Can suppress melanochrome and form, to treat yellowish-brown class, freckle isochrome disposition tetter has good effect.Someone adds Radix Angelicae Sinensis in cosmetic cream, the class's of the dispelling frost to, to ask for skin nutrition, prevents the yellowish-brown class of acne, effects such as freckle.Without any side effects through observing.Radix Angelicae Sinensis can promote natural on-off cycles of hair growth, and the hair conditioner elder generation hair cream with Radix Angelicae Sinensis is made can make hair soft shinny, is easy to combing.

5, prevent and treat gynecopathy: from China Northern and Southern Dynasties, Radix Angelicae Sinensis is regarded as the treasure of invigorating blood circulation of enriching blood, its energy tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, damp face skin moisten, and the strong body of myogenic is promoted longevity, and is playing the part of extremely important role in the protection women's health.LI Shi-Zhen thinks that Radix Angelicae Sinensis is the good medicine that the woman transfers blood.

In sum, this product have delay senility, effect such as sexual function improving, raising immunizing power, anti-fatigue anoxia-tolerance.

Manufacture craft: 1, raw material mixes pulverizing: all raw materials mix pulverizing in will filling a prescription earlier.

2, raw water lixiviate: will mix the raw material of pulverizing and be divided into two equal portions, a copy of it raw material adds 1: 6-8 water logging bubble boils after 1-2 hour and filtered to get filtrate one in lixiviate 1-3 hour, for the second time lixiviate raw material filter residue adds 1: the water boil lixiviate of 4-6 two, two filtrates that filtered to get filtrate in 1-2 hour are mixed into water extract.

3, steeping in wine is carried: another part raw material is added 1: cold soaking is carried 7-15 days in the barley wine of 8-15 liquor (50-60 degree), and shake 1-2 every day, filter the steeping in wine extract.

4, mixing preparation: preceding operation is made flooding filtrate and steeping in wine carry filtrate mixing, add the auxiliary material dissolving and stir.

5, precipitation: the vat liquor that will stir precipitation clarification in 48 hours.

6, filter: the vat liquor of post precipitation is sent into filter filter.

7, filling and capping: the vat liquor after will filtering is sent into filling machine, and can is also capping in bottle.

8, test package: with the work in-process after the can, the packing that is up to the standards becomes formal product.

Raw material mixing pulverizing process is in order to extract the process of whole effective constituents in the raw material.Two kinds of solvent extraction operations of Fen Shui and wine are the processes that extract the effective constituent in the raw material and reduce alcoholic strength for more effective.The mixing preparation operation is that water extract and the steeping in wine extract that preceding operation makes mixes, and adds the process that the auxiliary material dissolving stirs.The precipitation operation is in order to improve the process of product transparency and quality.Filter operation and be in order to filter out the suspended substance in the vat liquor and the process of impurity.The filling and capping operation is that the vat liquor after filtering is sent into the process that filling machine pours into bottle and carries out capping.The test package operation is with the work in-process behind the preceding operation filling and capping, is up to the standards, and packing becomes the process of formal product.

Six, quality standard:

1, physical and chemical index:

Alcoholic strength 38%

Hide Chinese caterpillar fungus g/100ml 1.5

Genseng g/100ml 3

Hide Radix Astragali g/100ml 6

Hide matrimony vine g/100ml 5

Hide Herba Cistanches g/100ml 5

Hide cynomorium songaricum g/100ml 4

Hide sealwort g/100ml 6

Safranine red-spotted stonecrop g/100ml 4

ZANGDANGGUI g/100ml 5

2, instructions of taking: every day twice, each 30-50ml

3, be not suitable for the crowd: children and youth.

Seven, embodiment: get and hide 1.5 kilograms of Chinese caterpillar funguses, 3 kilograms of gensengs, hide 6 kilograms of the Radixs Astragali, hide 5 kilograms of matrimony vines, hide 5 kilograms of Herba Cistanchess, hide 5 kilograms of cynomorium songaricums, hide raw materials such as 6 kilograms of sealworts, 5 kilograms of ZANGDANGGUI, 4 kilograms of safranine red-spotted stonecrops, mix the back pulverizing and be divided into two equal portions, the lixiviate respectively of water and liquor, the water logging bubble that lixiviate for the first time adds a copy of it raw material 1: 8 boils lixiviate after 2 hours and filtered to get filtrate one in 2 hours, the water boil lixiviate that added 1: 6 of lixiviate raw material filter residue for the second time filtered to get filtrate in 1.5 hours two, twice lixiviate filtrates mix water extract.The liquor lixiviate is carried 15 days with the liquor cold soaking that another part raw material added 1: 10, shake every day twice, filter to such an extent that steeping in wine is carried filtrate, water extract and steeping in wine extract are mixed into the steeping in wine extract, add the auxiliary material dissolving, the precipitation that stirs was filtered in 48 hours, sent into filling machine and poured into bottle and capping, be up to the standards, packing becomes formal product.

Claims (2)

1, the Tibetan pharmaceutical health care wine manufacture craft is: raw material mixes to be pulverized, the secondary flooding, and one time steeping in wine is carried, and water and steeping in wine extract mixing preparation stir, and precipitation, filtration, filling and capping, test package become formal product.

2, processing condition are: hide 1.5 kilograms of Chinese caterpillar funguses, 3.0 kilograms of gensengs, hide 6 kilograms of the Radixs Astragali, hide 5 kilograms of matrimony vines, hide 5 kilograms of Herba Cistanchess, hide 4 kilograms of cynomorium songaricums, hide 6 kilograms of sealworts, 4 kilograms of safranine red-spotted stonecrops, ZANGDANGGUI waits raw material to mix and pulverizes for 5 kilograms and is divided into two equal portions, the water logging bubble that a copy of it raw material added 1: 8 boiled lixiviate in 2 hours and filtered to get filtrate one in 2 hours, the water boil lixiviate that the raw material of lixiviate for the second time filter residue added 1: 6 filtered to get filtrate two in 1.5 hours, 1: 10 liquor of another part raw material adding (alcoholic strength 60 degree) lixiviate 15 days, shake every day 2 times, filter wine extraction liquid.Water and wine extraction liquid stir after mixing the dissolving of adding auxiliary material, precipitate 48 hours after-filtration, send into filling machine can also capping in bottle, are up to the standards, and packing becomes formal product.