CN102485266A - Formula of five-tree sap oral liquid having effects of enhancing immunity, delaying senescence, maintaining beauty and keeping young - Google Patents

Formula of five-tree sap oral liquid having effects of enhancing immunity, delaying senescence, maintaining beauty and keeping young Download PDF

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CN102485266A
CN102485266A CN2009100935732A CN200910093573A CN102485266A CN 102485266 A CN102485266 A CN 102485266A CN 2009100935732 A CN2009100935732 A CN 2009100935732A CN 200910093573 A CN200910093573 A CN 200910093573A CN 102485266 A CN102485266 A CN 102485266A
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oral liquid
enhancing immunity
ganoderma
slow down
pollen
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杨峰
陈晶莹
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Abstract

The invention discloses a formula of a five-tree sap oral liquid having the effects of enhancing immunity, delaying senescence, maintaining beauty and keeping young. The formula comprises wine, dragon spruce seed, Resina Draconis, arborvitae seed, pine pollen, gingko, ginkgo pollen, camellia powder, lotus powder, ginseng, ganoderma lucidum, polygonum multiflorum, Poria cocos, tremella, honey and rose powder, peach blossom, and jasmine. The oral liquid is prepared by using the following steps: sealed immersion, fine blending, refrigeration, clarification, filtration, clarification treatment, and sterilization. The formula of the five-tree sap oral liquid has the effects of enhancing immunity, delaying senescence, maintaining beauty and keeping young.

Description

A kind of five resin oral liquid prescriptions with enhancing immunity, slow down aging, looks improving and the skin nourishing effect
Technical field
The present invention relates to a kind of five resin oral liquid prescription biological medicine engineerings with enhancing immunity, slow down aging, looks improving and the skin nourishing effect.
Background technology
At all times; Much human knows that all ginkgo, pinaster, Cupressaceae, Sophora japonica L. and jujube tree all are the hollywood lignumvitaes more than thousand, and the ginkgo of more than 3000 year the first under heaven is not only arranged at present, fox-brush pine in 4769; Yellow Emperor, a legendary ruler Cupressaceae in 5000, and the Sophora japonica L. of more than the 1000 year Sui Dynasty and the jujube tree of the Tang Dynasty are arranged.The big tree that originates in US West in addition and the monkey-bread tree that originates in Africa and originating in Australianly all can live four, 5,000 years by tree; German natural scientist Alexandria well-known throughout the world. Feng. big vast fort finds that through the annual ring of tree the Folium Dracaenae cambodianae that originates in Africa lived 8000, and the scientist of Sweden finds that a PiceameyeriRehd. Et Wils. lived more than 9550 year.They can be rated as the life of " alive for evermore " on the earth.Be full of the sign of life on our earth, the high mountain that blows from never to see the sun or the sky deep-sea to high wind can both be found the existence of life everywhere.Statistics according to this, total microorganism kind more than 80,000,460,000 kinds of plants, more than 100 ten thousand kinds of animals on the earth, though their morphosis, life habit etc. vary, they all have one to be different from abiotic common ground, Here it is life.All biologies all are made up of the product of cell and cell; All life entities no matter be unicellular organism or multicellular organism, all have identical chemical constituent, all contain saccharide, protein, nucleic acid and four kinds of organic molecules of lipid; All to obtain nutrition and energy through metabolism; All cells all carry out two types of chemical reactions constantly: a kind of ingredient that will convert cell from the nutrient substance in the external world into, another will get into intravital nutrient substance and decompose to obtain the cellular activity energy needed.All biologies all have common material and architecture basics, and irritability is all arranged, and can both grow, and grow, and reproduction all will be passed to the next generation to the character of previous generation through hereditary variation, constantly evolve through variation again simultaneously.That is to say that actual to climb the tree with people's life characteristic be identical.Be but problem, why the tree of higher plant can live several thousand, and higher mammal people's life-span is general not enough century-old, differs the huge spread about 100 times? I want to mainly contain following three aspects:
At first, just there is longevity gene in " alive for evermore " tree in its primitive life is born cell.It is said that initial origin of life is around the hot spring of the submarine volcano outburst formation of the original earth.The chemical element that constitutes life is accidental formation, so the gene of the life that produces just has nothing in common with each other.
Secondly, in the plant cell body chloroplast is arranged, make needed nutrition through photosynthesis, the cell of humans and animals does not have chloroplast, can not carry out photosynthesis and make needed nutrition.The organism intracellular metabolic is crossed and is become comprising a series of complicacies and material conversion clocklike and Conversion of energy.Green plants can utilize solar energy, with saccharide, fat and the protein etc. of simple materials such as water, carbon dioxide and inorganic salt through the synthetic complicacy of series reaction; And humans and animals can utilize these materials of phytosynthesis, through the string reaction, digests and assimilates, and is converted into the part of health, is accomplished vital movements such as growth, growth, breeding.That is to say that the people relies on plant and survives, and the people of " is with the food day ", what generations only ate is that life cycle only has some months, and how long-lived one-year-old one withered and flourishing mixed grain rice herbaceous plant is! Even if the animal life cycle of producing meat, egg, milk is only several years or decades also, also can not help people's life lengthening, more needn't look to those mixed; The health product of import that dragons and fishes jumbled together; Though through identifying certain effect is arranged,, health longevity is not had substantial help because the raw material life cycle is short; For example Lac regis apis is goodies, but worker bee generally only lived 30 days; Soybean isoflavone also is goodies, and sow in spring and reap in autumn for bean plant, and life cycle also only has some months, though seed can be preserved several years, goes down still only to live some months but plant.I met the director of the board of directors of the U.S. old association of anti-rate; We can say; At present all in the world health product and all antiaging agents, and comprise the scientific and technical ment that genetic engineering is all, all be difficult to help the people to live to 120 years old or 150 years old human due life time.So the plant product in the life-span that every basically life cycle is ultra not remarkable all can not help the people to live and arrive due life time.My this saying, perhaps the someone opposes, but over the past thousands of years, especially modern age, external health food practical experience was such.Even if its effect of the elite of single millennium plant species also is limited; Have effect of prolonging life like the precious Pollen Pini of state, the past is that the emperor drinks, but does not also drink out which emperor more than 100 year old; Because it is the male sex cell of pinaster after all; Have only to pool together the elite of hollywood lignumvitae species more than multiple thousand, just can bring into play anti-aging effects truly, most possibly help the people to live by 150 years old the human due life-span.China's Chinese medicine preparation often all is to pool together the similar functional component medical material of twenty or thirty kind.Like 36-flavor Glutinous Supreme Being emperor's ball, do not play pharmacological action and see Supreme Being emperor's ball simply or two flavor Supreme Being emperor balls.
Have, the world is material again: material is the carrier of life, and life is the motion of material.There are 90 kinds of elements in the earth's crust of earth surface, and the hollywood lignumvitae of big tree with deep roots can both be extracted basically.So hollywood lignumvitae has no lack of nutrition, most hollywood lignumvitaes are not sick yet, must be long-lived; And person walks is in any element that can not directly extract on the earth on the earth's crust, can only be through the things channel or eats a little incomplete foods, and the zero a little common nutrition of scrappy broken absorption are accepted in the destiny arrangement passively.Really the ruler of ancient times China and foreign countries is expecting " alive for evermore " always, though constantly make pills of immortality and look about miraculous cure, fails to reach this purpose all the time.In the underdeveloped age of that science, obviously be a kind of fantasy, especially lean on feudalistic superstition.Pass on from one to another, to sovereign power and the greediness of enjoying high position and great wealth not to the utmost, Emperor Qin long-livingly dreams of obtaining.In order to realize the not dead dream of oneself, Emperor Qin has truly sent Xu Fu to lead thousands of young boys and girls, goes to the East Sea to seek not dead elixir for him.As a result, not dead elixir is not obtained, and people such as Xu Fu also vanish into the void.Once the someone said that the Japanese was exactly the offspring that thousands of whole young boys and girls are lost in that time.Though Emperor Qin puts into practice long-living action and do not achieve success, its influence is not little, in this world because the legends about elixir have been spread much in his current action.Someone persuades can be long-living with Jindan; Someone say eaten life fruit can be long-living; The somebody think eaten mica sheet can be long-living etc.It is because of these legends have a lot of our emperor: If Emperor Yang Guang, Li Shimin, Emperor Xian Zong Li Chun, Li Heng Tang Mu Zong and Zhu Hou Cong Ming emperors, who, at that time because the science behind pills containing mercury lead excessive elixir - "saver" poisoning entirely their later years.So comprise any health-preserving method of " emperor in through ", any imperial physician and health care doctor all can not warrantor living person's class to life time should be arranged.
Through above analysis, we know that " alive for evermore " tree life-prolonging profoundness is to exist in its body longevity gene of crucial importance, very rich nutrient contents and chemical constituent.They inhale the anima in the world, the elite of getting all things on earth just as being natural high-tech machine ", impersonal force institute could be for also! That can affirm says, no matter science and technology is flourishing in what degree, all can not artificial producing " inhale the anima in the world, the elite of getting all things on earth ", high-tech machine.Just there are nutritional labeling and chemical constituent more than 160 kinds like the slight blade of ginkgo a slice; A small pollen just has 200 multiple nutritional components; Especially contained flavonoid and terpenoid lactone chemical compound can effectively be removed killer's free radical of human body cell, suppress cell membrane lipid peroxidation; Play slow down aging, prolong the effect of life.Exist as hollywood lignumvitae on the earth since I think, " alive for evermore " life since the people is identical with the vital signs of tree, since all biologies can both will convert the ingredient of cell through metabolism from the nutrient substance in the external world into.The people has only long-term absorption " anima in the suction world, the elite of getting all things on earth " the synthetic natural nutrient component of tree alive for evermore so, just might help the people to live more than the due life time.This is to be based upon the fact and the people of " alive for evermore " tree and to set on the vital signs scientific evidence basis in like manner.Because existing Sophora japonica L. and the jujube tree in more than 1000 year; The ginkgo in more than 3000 year, pine and cypress tree in 5000, the Folium Dracaenae cambodianae in more than 8000 year; The PiceameyeriRehd. Et Wils. trees in more than 9000 year etc., why " alive for evermore " is because the nutritional labeling that forms the gene of the interior congenital heredity of its body and the day after tomorrow after all.The people has only the long-term an amount of effective ingredient that absorbs them, is converted into a health part through metabolism, could help the people long-lived.Though can not with the same longevity of tree, rely on their species in 1 years, the vitality in 10000000 year; The probability that helps the people to live more than 150 years old due life time is very big, thereby reaches enhancing immunity, prevents and treat multiple disease; Slow down aging, the effect that prolongs life.Be actually through the method for patched gene and help people's longevity.Just through for a long time, absorb hollywood lignumvitae natural plant synthetic " alive for evermore " green nourishing composition in right amount, make it to become all the time the ingredient of human body cell, help people's longevity.Because relying on plant originally, the people survived.Scientist successfully prolongs 10 times to saccharomycetic life through repairing the way of yeast gene.Ginkgo; Pinaster, Cupressaceae, Camellia sinensis, Sophora japonica L., monkey-bread tree, Folium Dracaenae cambodianae, PiceameyeriRehd. Et Wils. are set several multiple rare Chinese medicines such as hollywood lignumvitae and Radix Ginseng, Ganoderma, Radix Polygoni Multiflori, Poria, Rhizoma Polygonati more than big thousand; The one-tenth phase-splitting is melted, effect is close; And not opposite making a concerted effort, as long as can extend to people's life-span more than the due life time just passable.Good through what say in the emperor: hereat with the sage, treating the disease affected not, preventive treatment of disease.Husband's disease becomes, rethinks and controls it, just as wearing well yearningly, struggles against and the casting hammer, and also do not exhale evening! People to two just senesced more than ten years old, and especially modern medicine study is found, cancerous cell is all arranged in the human body more than 40 years old.The multiple pure natural effective ingredient of comprehensive, isostatic hundreds of that five big hollywood lignumvitaes are contained, especially significant composition all has enhancing immunity, prevents and treat multiple disease, slow down aging, the effect that prolongs life.Ancient sage's speech: " doctor comes from wine ", " wine is the king of medicine ".Cover in the Gu, wine often is used for the doctor, and doctor's wine also commonly used is cured the disease also.Wine is good solvent, and each effective ingredient all dissolves in the wine in the medicine, and efficacy enhanced by wine, wine help the medicine prestige, and medicine, wine mutual reinforcement between are usefulness, in a lot of diseases control real be useful.Li Shizhen (1518-1593 A.D.) is said: " wine, the U.S. high post in sky also.Few drink then with the blood circulation of qi promoting, the mind invigorating resisting cold relieves the lonliness and grief "; Sun Simiao is said: " two or three doses in winter wear medicated wine, promptly end the beginning of spring, the lifelong Chang Er of this method, then all kinds of diseases and ailments are not given birth to." so this prescription is dissolved in script to the effective ingredient of hollywood lignumvitae in multiple thousand with regard in the wine of having good health and a long life; be of value to absorption of human body more, make it the species in 1 years, the longevity gene in 10000000 year; become the ingredient of human body cell all the time, thereby help human health long-lived.
Be brief introduction below to above several kinds of hollywood lignumvitae species more than thousand and the selected formula material of other part:
[ginkgo] Juxian County, Shandong floats under the mountain, has one tree to reach the ginkgo in more than 3,000 year age, and is vigorous so far.Institute planted when this ginkgo of legend was in week initial stage in the Western Zhou Dynasty public eastward fight the east.History is carried once eastern cross " the Testudinis illiteracy " of public eastward fight of week, and the Fu Laishan that sets foot on so is also just credible in a measure.This ginkgo vitality is extremely strong, and still branch and leaf are luxuriant so far, and contemporary calligraphist Mr. Wang Binglong has driven quill to write for it the autograph of " Semen Ginkgo first tree all over the world ".UNESCO also play his video recording.Extract main component contains flavonoid, lactone compound etc.Wherein flavone compound mainly divides three types: flavone (alcohol) and glycosides thereof, like Beijing opera ketone etc.; The flavol class is like catechin etc.; Bisflavones is like ginkegetin etc.Other isolates 5 kinds of diterpenoid-lactones (GA, GB, GC, GJ, GM), a kind of sesquiterpene lactones (being bilobalide).Prove that through scientific research personnel's research both at home and abroad and through clinical practice Semen Ginkgo extrac has following pharmacological action at present: 1, remove free radical, suppress cell membrane lipid peroxidation; 2, the fly up and down platelet aggregation that platelet activating factor causes, the formation of microthrombus; 3, change hematochemistry, reduce blood viscosity, the microcirculation improvement obstacle; 4,, have and improve preferably and facilitation to brain blood circulation and brain cell metabolism; 5, improve immunocompetence; 6, improve the function of respiratory system, digestive system, urinary system, reproductive system; 7, antibiotic, antiinflammatory, antiallergic, antiviral, antitumaous effect.Various preparations so that this extract is processed show through clinical research, have significant curative effect to preventing and treating coronary heart disease, heart strand disease, myocardial infarction, cerebral embolism, cerebral vasospasm, cerebral trauma sequela, alzheimer disease and the hypophrenia etc.
Relevant argument: Qin Hongbin [1] research Folium Ginkgo extract (GBE) is to senile rat immunologic function and antidotal effect.The continuous stomach of method: GBE is raised senile rat after 7 days (0.4mg day /), detects T lymphopoiesis level, NK cytoactive, the ability of antibody forming cell's secretory antibody and blood serum IL-6 level; Get blood, liver, brain after 30 days, measure superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) vigor, malonaldehyde (MDA) content and monoamine oxidase, MAO (MAO) vigor.The result: compare with matched group, T lymphopoiesis level, the NK cytoactive, the ability of antibody forming cell's secretory antibody and blood serum IL-6 level significantly increase; Simultaneously significantly increase SOD in blood and the liver, GSH-Px vigor, significantly reduce MDA content.The MAO vigor is not seen significant difference; Significantly reduce MDA content in the brain, significantly reduce MAO vigor in the brain.Conclusion: GBE has immunoloregulation function and the antidotal effect that strengthens senile rat.
Li Jing [2] observes Folium Ginkgo extract (EGb761) the effect variation of Aged Erythrocyte adenosinetriphosphataes (ATPase), superoxide dismutase (SOD) and malonaldehyde (MDA) content down, inquires into the antidotal mechanism of EGb761.Method adopts the constant water bath box method of hatching to simulate erythrocytic naturally-aged process, observes EGb761 to Aged Erythrocyte MDA content, SOD and the active influence of ATPase.The result organizes relatively with old and feeble, and the erythrocyte MDA content of EGb761 group obviously reduces, SOD, the active obviously rising of ATPase, and difference has extremely significantly meaning (t=2.02-70.06, P < 0.05,0.001 >.Conclusion EGb761 can improve erythrocytic oxidation resistance, and the protection erythrocyte membrane protein slows down erythrocytic ageing process.
Lv Ping [3] is employed in the reaction system and adds the escherichia coli extract and come the partial simulation cellular environment, further analyzes the scavenging action to ultra-oxygen anion free radical, hydroxy radical clearance rate and hydrogen peroxide in cell of flavone extract in the Folium Ginkgo.The result shows that flavone extract has tangible scavenging action to two type free bases and hydrogen peroxide, but in reset procedure the interaction more complicated of flavonoid and lactone.
Wang Guoqing [4] carries out Folium Ginkgo extract causes the rabbit oxidative damage to carbon tetrachloride protective effect research.Method: laboratory animal is divided into normal control group (A), damage model group (B), medicine I group (C), medicine II organizes (D); Difference first intravenous injection normal saline (A, B); Folium Ginkgo extract (C, D), intraperitoneal injection of saline (A), carbon tetrachloride (B, S, D) again; Measure levels such as SOD in serum, GSH-PX, GSH, active oxygen, XOD at 4h (A, B, C), 24h (D) the heart liquid of dehematizing.The result: (1) and matched group relatively, levels such as damage model group blood active oxygen, the XOD (P (0.05) that obviously raises.Enzyme levels such as SOD, CAT, GSH-PX reduce obviously that (P (0.01), GSH do not have significant change (P (0.05).(2) levels such as medicine I group, medicine II group blood active oxygen, XOD are starkly lower than the damage model group (P (0.05), medicine II group SOD, (P (0.05), blood GSH do not have significant change (P (0.05) to GSH-PX apparently higher than the damage model group.Conclusion: Folium Ginkgo extract has the free radical anti-oxidative damage effect of eliminating, and one of its important channel is to reduce level such as blood active oxygen, XOD and increased SOD, CAT, GSH-PX enzymatic activity.
Miao Jun [5] observes influence and the antioxidation of Semen Ginkgo extrac (GBE) to hyperlipidemia rats blood lipid metabolism.The method high lipid food is fed 21d; Give rat oral gavage GBE (50-100 simultaneously; 200mg/kg) measure serum total cholesterol (TC) and triglyceride (TG), HDL-C (highdensity lipoprotein-cholesterol), LDL-C (LDL-C) activity; Measure lipid peroxide (LPO) and superoxide dismutase (SOD) activity in serum and the hepatic tissue, and observe the liver fat deposition conditions.(100,200mg/kg) group all can obviously reduce serum TC, TG, LDL-C activity and serum and hepatic tissue LPO to GBE, and can elevating HDL-C and serum regulating liver-QI tissue SOD activity as a result.The visible liver fat deposition of pathologic finding obviously alleviates.Conclusion GBE possibly correct the Radical Metabolism disorder through adjustment lipoprotein-cholesterol metabolism, and blood fat and antioxidation are transferred in approach performances such as enhancing activities of antioxidant enzymes.
In recent years; The relation of oxygen-derived free radicals and human diseases more and more receives the concern of Chinese scholars. and research shows; Playing an important role in oxygen-derived free radicals generation and the unbalance generation of scavenging system, the evolution in pulmonary heart disease. Jiang Junguang research is intended to understand the influence of Folium Ginkgo extract to the damage of aged lung cardiopathia acute attack stage patient anti peroxidation of lipid, inquires into its clinical treatment meaning [6] to aged lung cardiopathia acute attack stage patient.
Shi Xiaoqin [7] adopts 32 of animal health Japan white big ear rabbits, is divided into 4 groups at random, and 8 every group, 1 group is sham operated rats, and 2 groups is the ischemia-reperfusion injury model group, and 3 groups is middle dosage extract of ginkgo biloba for treating group, and 4 groups is heavy dose of extract of ginkgo biloba for treating group.Experimental studies results shows that Folium Ginkgo extract has antioxidation.
Zhang Jing [8] with drosophila survival experiment and the experiment of quick aging model mice to the research that experimentizes of Folium Ginkgo extract antioxidation.In the drosophila survival test, it is good that each organizes the fruit bat vegetative activity.The number average comparison in dead day of male fruit bat 0.0600% and 0.1800% concentration group half prolongs 5 days according to group; 0.0200%, 0.0600% and 0.1800% concentration group average life and average maximum life span all prolong than matched group, and statistical significance (P＜0.05) is arranged.In quick aging model mice (SAM the wear out Mus) experiment. the aging Mus per os of SAM is given the Folium Ginkgo extract of various dose; Contaminate and get its LH after 60 days; MDA all is lower than matched group among the SAM, SOD and all is higher than SAM kind matched group in each dose groups homogenate, and statistical significance (P＜0.05) is arranged.This experimental studies results shows that Folium Ginkgo extract has antioxidation.
Folium Ginkgo extract has functions such as the blood circulation of improvement, resisting myocardial ischemia reperfusion injury and the normal Radical Metabolism of protection hepatic tissue; And the central nervous system had certain influence, it is relevant with terpene lactones that its mechanism and Folium Ginkgo extract contain multiple flavonoid glycoside.Folium Ginkgo extract can reduce the formation of oxygen-derived free radicals and the release of superoxide anion through improving liver cell pigment P-450 enzyme system, thereby brings into play indirect antioxidation [9].
Palace rosy clouds [10; 11] set up an amount of swimming and the power of irritating the mice of obeying Folium Ginkgo extract and exhausted the swimming test model; Survey the vigor of the glutathion peroxidase (GSH-Px) in its blood, the result shows that the GSH-Px vigor of irritating the mice of clothes Folium Ginkgo extract is significantly higher than matched group separately; Therefore; Taking Folium Ginkgo extract and can alleviate endogenous free radical O-// 2 that motion produces, H2O2, and the injury of organic peroxide mice, explain that Folium Ginkgo extracts and has stronger free radical resisting and damage and lipid-peroxidation effect, is natural free radical scavenger.
Zhou Junfu [12] inquires into the effect of Folium Ginkgo antioxidation and anti peroxidation of lipid damage.Method detects blood plasma vitamin C (P-VC), vitamin E (P-VE), beta-carotene, lipid peroxide (P-LPO) and erythrocyte superoxide dismutase (E-SOD), catalase (E-CAT), glutathion peroxidase (E-GSH-PX), lipid peroxide (E-LPO) value of 78 routine patient with angina pectoris before and after the treatment of gingko leaf preparation taponin.The result is relatively preceding with treatment, and Folium Ginkgo antioxidation and anti peroxidation of lipid damage effect are obvious.
Chinese scholars proves the research of Folium Ginkgo extract (Ginkgobilobaex-tractGBE); Have activity, blood circulation promoting and the brain metabolic function of catching free radical, suppressing platelet activity factor (PAF), and GBE is used for treating cardiovascular disease such as cerebral function is incomplete, atherosclerosis clinically.This paper studies regulating action and the mechanism thereof of GBE to the senile rat immunologic function, for GBE is used for as antiaging agent experimental basis [13] being provided clinically.
Qin Hongbin [14] inquires into the effect of Folium Ginkgo extract (GBE) to the rat immunity function.Method: using monoclonal antibody and radioactivity infiltration method detect technology such as thymus T cell and the inductive splenocyte breeder reaction of ConA.GBE is to rat immunity function effect index.Result: GBE increases thymus Thy-1 cell percentage, obviously strengthens the inductive splenocyte propagation of ConA.Increase phagocytosis of macrophages, improve periphery blood T lymphocyte esterase dyeing rate, serum IgG content is increased, obviously increase the weight of thymus, spleen.Conclusion: GBE has the effect that improves the rat immunity function, can be used as immunostimulant.
The influence of Folium Ginkgo extract (EGB) to memory of cyclophosphamide model mice and immunity observed in bright [15].Method is induced the low and learning memory disorder model of C57BL/6J immune function of mice with cyclophosphamide.Adopt the diving tower method to do behavior and detect, simple immunodiffusion method and dinitrofluorobenzene are induced the ultra quick behavior detection of doing of delayed, and simple immunodiffusion method induces the delayed hypersensitivity method to measure relevant immune indexes with dinitrofluorobenzene.As a result EGB (40,80mg/kg/d * 20d, ig) can reduce little diving tower errors number, prolong SDL, shorten EL; Making mice reduce immunologic function improves significantly.
Zhang Yan [16] observes Folium Ginkgo extract (EGb) to memory of hydrocortisone model mice and Immune Effects.Method hydrocortisone 4mg/kg/d * 21d, sc inducing mouse immunologic hypofunction and learning memory disorder model adopt the diving tower method to do behavior and detect; Mtt assay is used to measure immune indexes.(40,80mg/kg/d * 31d ig) can reduce the diving tower errors number of mice to EGb, shortens escape latency as a result.(20,40,80mg/kg/d * 31d ig) can promote the T lymphopoiesis to EGb, improves IL-1 and IL-2 level.Conclusion EGb all improves significantly to inductive memory dysfunction of hydrocortisone and immunologic hypofunction.
Jiao Minhua [17] inquires into the effect of Folium Ginkgo to hematid immunity function.Method adopt ginkgo biloba succi respectively with 40 routine healthy male erythrocyte effects, and observe its with sensitization yeast, non-sensitization yeast, normal saline hatch respectively the back be RBC-CR, RBC-IC rosette rate.The RBC-CR1 rosette rate of ginkgo biloba succi is apparently higher than saline control group (P＜0.01=as a result.Conclusion Semen Ginkgo fluid power hematid immunity function.
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17. burnt quick China. Folium Ginkgo is to the hematid immunity function experimental study of effect. Shenzhen combination of Chinese and Western medicine magazine .2002 12 volume 1 phase: 30-31
The fox-brush pine in [pinaster] California, USA White awns court of a feudal ruler geographic " Mei Xiusaila " by name has grown 4769.China's Jiuhuashan phoenix Age-old pine trees pass on from one to another this pine and have seen the world surplus in the of 1,400 year, are planted by refreshing monk's cup in Northern and Southern Dynasties periods crosses.The pinaster plant chemical ingredient is complicated, how resinous, volatile oil.Its Pollen Pini and Colophonium are important medical materials, have many-sided health care curative effect.Pinaster is not only long-lived but also green for a long time, and the chemical constituent that it is complicated more should be to help human research's rare first-selected species of having good health and a long life.
Pollen Pini is Pinus massoniana Lamb (Pinus massoniana Lamb.), Pinus tabuliformis (Pinus tabulae formis Cart.) or the dry pollen that belongs to several plants together, for " Chinese pharmacopoeia is recorded kind.Pollen Pini is natural miniature nutrition library.The Nature has been created green for a long time, the not old miracle in thousand of pinaster, and its Source of life is exactly the spermatid of pinaster a---pollen.Qin Li Li [1] has been made summary to discrimination method, pharmacological action, the clinical practice of the main former plant of Pollen Pini since 2004.
Multiple nutrients materials such as Pollen Pini rich in proteins, nucleic acid, phospholipid, vitamin, free amino acid, mineral and trace element, amino acid content is higher than natural Pollen Pini behind the Pollen Pini breaking cellular wall, more can strengthen humoral immune function, and increases the availability of zinc.Pollen Pini can effectively reduce the blood fat in the hyperlipemia serum, slow down aging, skin maintenance; Promote the utilization of body to zinc; Can treat habitual constipation, habitual diarrhea, help the liver function recovery of chronic persistent hepatitis, can alleviate diabetic symptom; The Pollen Pini external can also be treated diseases such as diaper dermatitis, decubital ulcer and cervical erosion, is the Chinese medicine that a kind of side effect is little, nutritive value is very high [2].
Li Xianhua [3] is the breaking cellular wall and the pharmacologically active of breaking cellular wall Pollen Pini not relatively, observes the two influence to the rabbit function.Method: the two generates the influence that reaches Turnover of Mouse Peritoneal Macrophages Wu function laboratory observation to the mice serum hemolysin.The result: broken breaking cellular wall can obviously promote chicken red blood cell mice immunized serum hemolysin (IgM) to generate with breaking cellular wall Pollen Pini not, has the humoral immunization of enhancing effect (P＜0.05=.And the two all has and improves the cytophagous trend of Turnover of Mouse Peritoneal Macrophages, but with matched group than no significant difference (P＞0.05).Conclusion: do not find breaking cellular wall with breaking cellular wall Pollen Pini is not to the notable difference (P＞0.05) of rabbit epidemic disease function, breaking cellular wall Pollen Pini can directly not used.
Zhao Lixin [4] observes the anti-aging effects of Pollen Pini.Method is with the forage feed mouse aging that contains Pollen Pini; Measure the activity of superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GSH-Per) in the mice serum; Lipofuscin (Lf) content in the mensuration cerebral tissue in malonaldehyde (MDA) content and cerebral tissue and the liver is measured the weight of thymus and spleen and the phagocytic function of reticuloendothelial system simultaneously.Pollen Pini can obviously increase SOD in the mouse aging serum, CAT, GSH-Per activity as a result, the Lf content in the reduction cerebral tissue in MDA content and cerebral tissue and the liver, and increase thymus and spleen quality, improve the reticuloendothelial system phagocytic function.The conclusion Pollen Pini has anti-aging effects.
Song Chengjun [5] inquires into the influence of Pollen Pini to the old and feeble rat liver oxidation resistance of D-galactose.Method: the continuous lumbar injection of D-galactose is made the rat model of subacute aging, adopts biochemical method to detect vigor and the TAC (T-AOC) of respectively organizing superoxide dismutase in the liver tissues of rats homogenate (SOD), glutathion peroxidase (GSH-PX).The result: the old and feeble rat SOD of D-galactose vigor, GSH-PX vigor and T-AOC all obviously descend, with normal rat comparing difference remarkable (P＜0.01); SOD vigor, GSH-PX vigor and TAC are significantly increased behind the Pollen Pini gastric infusion; The effect of Pollen Pini is better than VE (P＜0.01).Conclusion: Pollen Pini can significantly improve the ability of subacute old and feeble rat liver antioxidant radical, has certain function in delaying senility.
Bao Shanfen [6] studies Pollen Pini and the oxidation resistance and the mechanism of extract from pine needles in lipotropy antioxidation model system.Method: adopt the LDL oxidation reaction model and the Rose Bengal reaction model of copper inducible to estimate respectively.The result: the Pollen Pini ethanol extract has the effect of free chain reaction blocker preferably, postpones low density lipoprotein, LDL in the human plasma (LDL) oxidation effectively and generates conjugated diene.The Folium Pini ethanol extract is superior to Pollen Pini to the protective effect of LDL.In Rose Bengal system, Pollen Pini is with the generations of two kinds of mechanism inhibition lipid peroxidation of removing free radical and chelated copper, and Folium Pini is brought into play antioxidation mainly as free radical scavenger.Conclusion: Pollen Pini and Folium Pini are all brought into play good oxidation resistance in two lipotropy external models, and antioxidation mechanism is not quite similar.
Liu Yutian [7] inquires into the oxidation resistance of Pollen Pini, compares with antioxidation foodstuffs commonly used such as Fructus Mori, structure Qi, Fructus Jujubaes and compound.From the difference of permanganate indices value is that the height of polyphenoils content is arranged the antioxidant food of being studied, and is followed successively by Herba Cistanches, Fructus Mori, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Pollen Pini, the Radix Astragali, Fructus Jujubae; With putting in order of the external removing hydroxyl radical free radical of IX. deoxyribose oxidizing process ability height, then be the Radix Astragali, Semen Cuscutae, Pollen Pini, Fructus Jujubae, Herba Cistanches, Fructus Mori, structure Qi, Radix Rehmanniae Preparata.The result shows, Pollen Pini, the Radix Astragali, Semen Cuscutae, though the polyphenoils content of Fructus Jujubae is few, its ability of removing hydroxyl radical free radical is very strong.And learn that tentatively the ability that the polyphenoils in the Pollen Pini is removed hydroxyl radical free radical to composite material has synergism, this is that primary raw material compound highly effective non-oxidizability food lays the foundation for further studying with the Pollen Pini.
Niu Siyun [8] is through the mensuration to subacute old and feeble rat model serum superoxide dismutases (SOD), malonaldehyde (MDA), glutathion peroxidase (GSH-Px) and TAC (T-AOC); Observe the variation of rat sperm quantity, mobility and survival rate, thereby inquire into the anti-aging effects of Pollen Pini.The continuous lumbar injection of method D-galactose is made subacute old and feeble rat model, adopts biochemical method to detect the content of SOD, MDA, GSH-Px and T-AOC in each experimental group serum; Observed the variation of rat sperm quantity, mobility and survival rate.Subacute old and feeble rat model group SOD vigor, GSH-Px vigor and T-AOC all obviously descend due to the D-galactose as a result, and MDA content obviously rises, with normal control group comparing difference remarkable (P＜0.01); And SOD vigor, GSH-Px vigor and T-AOC three all are significantly increased after the Pollen Pini administration, and MDA content obviously descends; Pollen Pini can improve quantity, mobility and the survival rate of subacute old and feeble rat sperm due to the D-galactose.The conclusion Pollen Pini can significantly improve the ability of subacute old and feeble rat anti oxygen-derived free radicals, improves quantity, mobility and the survival rate of sperm, has function in delaying senility.
Zhao Lixin [9] inquires into the possible mechanism of action of Pollen Pini delaying cell aging, for new field is opened up in the research of Chinese medicine slow down aging.Method: Pollen Pini acts on human embryo lung (HEL) involution form fibroblast, the observation of cell speed of growth, and the beta galactosidase colouring method is measured the aging of cell, utilizes TRAP-ELISA to measure and handles the front and back end changes of telomerase activity.The result: after the Pollen Pini function cells, can obviously promote cell colony multiplication level, the involution form fibroblast significantly descends; Telomerase activation obviously rises, and certain dose-dependence is arranged.Conclusion: Pollen Pini is likely that through telomerase activation in active cell delaying cell aging, telomerase activate again and is likely that cell escapes old and feeble important mechanisms, shows that also telomerase has important function in the aging of cellular replication property.
[list of references]
1. Qin Li Li Tan Zhong scheme. the pharmacological action of Pollen Pini and clinical application research progress. the journal .2008 of Colleges Of Traditional Chinese Medicine Of Guangxi 11 volume 3 phases: 108-109
2. Zhao Li newly explains the land. the mechanism of action of Pollen Pini and clinical practice. and Jilin Chinese medicine .2004 24 volume 1 phase: 49-51
3. Lee shows Hua Dengxiaomei. breaking cellular wall and breaking cellular wall loose powder not are to the comparative study of Immune Function. the time precious traditional Chinese medical science traditional Chinese medicines .2001 12 volume 3 phases: 205-205
4. Zhao Li newly explains the land. the Pollen Pini experimental study about anti-senility. and modern medicine .2004 32 volume 2 phases: 74-76
5. Song quiet Ma Hechao of Pang Xiao that establishes an army. Pollen Pini is to the influence of the old and feeble rat liver oxidation resistance of D-galactose. the journal .2006 of Chengde Medical College 23 volume 3 phases: 233-235
6. Bao is apt to fragrant Cong Tao. and Pollen Pini and extract from pine needles be oxidation resistance and Study on Mechanism in the lipotropy extracorporeal model system. the journal .2006 of medical officer college of continuing education 27 volume 5 phases: 381-383
7. Liu Yutian. the research of Pollen Pini antioxidation. 4 phases of farming industry .2008: 24-27
8. it is quiet that cattle succeeds cloud Pang Xiao. and Pollen Pini is to subacute aging model rat experimental study about anti-senility. Chinese gerontology magazine .2005 25 volume 12 phases: 1504-1506
9. Zhao Li newly explains the land. the influence of Pollen Pini delaying cell aging and pair cell telomerase activation. and Sichuan traditional Chinese medical science .2004 22 volume 4 phases: 11-13
According to " books are integrated at all times " record, the huge arbor vitae at Shaanxi Huang Di Mausoleum place (the about 2.5m of the diameter of a cross-section of a tree trunk 1.3 meters above the ground) is planted for the Xuanyuan Supreme Being personally [Cupressaceae], claims Xuanyuan cypress or Yellow Emperor, a legendary ruler cypress.Be famous ancient and well-known trees at home and abroad, the overseas Chinese looks at activity with reverence through this measure row of being everlasting.The Semen Platycladi of Cupressaceae is that the sophisticated kernel of Cupressaceae plant contains cedar wood alcohol, sitosterol and Diterpenes composition, fatty again oil, a small amount of volatile oil, saponin, vitamin A, protein, lignin etc.The ability tranquilizing by nourishing the heart, the hidroschesis intestine moistening is used to treat diseases such as neurasthenia, cardiopalmus, insomnia, night sweat, constipation.
[Camellia sinensis] Yunnan " bright and beautiful elegant tea ancestral " promptly is grown in ancestral---the most ancient in the world Camellia sinensis of the Camellia sinensis of the fragrant bamboo mountain valley with clumps of trees and bamboo in Jin Xiu village, voe town, Fengqing County, side, the Lancang River; This Gu Camellia sinensis is high 10.2 meters, tree 11.1 meters * 11.3 meters, 5.67 meters of chest measurements; Base encloses 5.84 meters; According to textual criticism, the age of tree has reached 3200, can be rated as the first in the world.At present, the Shanghai Guiness Records is declared for this Gu Camellia sinensis by relevant department.Tea polyphenols (Tea Polyphenols) is the general name of polyphenols in the Folium Camelliae sinensis, is the natural additive of at present tool application prospect.Composition comprises flavanol compound, anthocyanin class, flavonoid, flavonols and phenolic acids etc., and is wherein important with flavanol compound material (catechin).Tea polyphenols claims that again tea is tanned or tea tannin, is one of Main Ingredients and Appearance that forms the Folium Camelliae sinensis color, smell and taste, also is one of Main Ingredients and Appearance that has in the Folium Camelliae sinensis health care.Scientist such as Taide professor research shows under the Chiba, Japan university mountain; Detoxifcation of tea polyphenols isoreactivity material tool and radiation resistance; Can stop radioactive substance to invade bone marrow effectively; And strontium 90 and cobalt 60 are excreted rapidly, and to be described as by health and medical circle " radiation jinx ", tea polyphenols is that human beings'health has been constructed the defence line of resisting radiation injury together.Tea polyphenols can be removed free radical superfluous in the body, stop lipid peroxidation, human body immunity improving power, slow down aging.Tea polyphenols has very strong non-oxidizability and physiologically active, is the scavenger of human free radical.The usefulness that 1 milligram of tea polyphenols is removed the deleterious excessive free radicals of human organism is equivalent to 9 microgram superoxide dismutase (SOD), is much higher than other allied substances.Tea polyphenols has the blocking-up lipid peroxidation, removes the effect of organized enzyme.According to Japanese Tian Tuoyong result of the test difficult to understand, confirm that the defying age effect of tea polyphenols is stronger 18 times than vitamin E.Tea polyphenols also helps to suppress cardiovascular disease, inhibition and effects such as peptide are protected in opposing virus bacterium, radioprotective injury and beauty treatment in addition.
The Camellia sinensis argument of being correlated with:
Cellular immunization T lymphocyte is the cell that has the self renewal ability in the peripheral blood, after it receives antigen or mitogenstimulated, can change the competent cell that multiplication capacity is arranged into from sophisticated terminal cell.What of its quantity are closely related with active power and body cell immunologic function.Chen Yuchun [1]Deng observing oolong tea and Jasmine tea to effect of immunologic function, find that 1% Jasmine tea can significantly promote the acid a-naphthols of peripheral blood acetolase and reveal (ANAE) positive lymphocyte % and absolute number, two kinds of tea influences of 10% are little.Ye Shi observes 5% green tea can significantly promote ehrlich carcinoma mouse blood ANAE positive lymphocyte %.The ANAE positive lymphocyte is the T cell, and prompting scented tea and green tea have the effect that promotes the T cell quantity.
Chen Yuchun [1]Find significantly (oolong tea is near the remarkable) promotion of 2% green tea, black tea, Ramulus et Folium Mussaendae Pubescentis 3H-TdR mixes, and points out 5 kinds of tea can measure the thin breast immunologic function of enhancing body in various degree.And cellular immunization is most important to prevention infection and tumor.Cyclophosphamide (CY) CDC capable of blocking suppresses DNA and protein synthesis.Make immunity with CY and receive to press down animal model, above-mentioned 4 kinds of tea can significantly promote its LSI (SI), the immunosuppressive action that prompting tea can anti-CY.Oolong tea, Jasmine tea are closely related to influence and tea concentration that mouse anti SRBC hemolytic antibody produces.The influence of 1% two kind of tea is little, and 10% two kind of tea then makes mice haemolysis rope antibody produce few, and wherein the half hemolysis value of oolong tea group (Hcm) significantly is lower than matched group, and prompting high concentration oolong tea suppresses antibody and produces.Lymphocyte is a cell line the most complicated in the body, can be divided into T cell, B cell, K cell and NK cell.Activated lymphocytes can be secreted the regulation and control that the various kinds of cell factor is participated in immunne response, and wherein interleukin II (IL-2) is a kind of broad-spectrum immunostimulant.2% oolong tea, jasmine Herba Astragali Sinici, green tea, black tea and Ramulus et Folium Mussaendae Pubescentis ability degree differ but promote the normal mouse lymphocyte to produce IL-2 significantly.During the T lymphocyte activation, IL-2 promptly with cell membrane on IL-2 combine, thereby promote its division, propagation, the cell quantity that causes participating in immunne response increases immunologic function.
Li Ping [2]Summarized tea polyphenols to the regulating action of animal immune and in the application of aspects such as antibacterial, immunomodulating, antiviral, antitumor, radioprotective.
Zhu Maoxiang [3]Inquire into preventive effect of tea on cancer by immune regulation mechanism.Bring out the experimental model of mouse tumor with carcinogen 4-methyl nitrosamine-1-(3-pyridine)-1-butanone, observe the change and the green tea of NNK induced mice immunologic function, the protective effect of compound tea and tea polyphenols.As a result behind the injected in mice NNK, in 4 weeks of observing, the peritoneal macrophage phagocytic function; The PBL chemiluminescence, tardy allergy, splenocyte antibody-producting cell number; And immune indexes such as spleen NK activity, increasing or reducing in various degree more all appears with the normal control group;
Yang Xianqiangs etc. [4] adopt ESR method (electron spin spectrometer method), chemoluminescence method (BCL method)-3 kinds of experimental models of photometry to measure, and prove that the efficient of GTPs elimination activity oxygen-derived free radicals reaches 92%～98%, obviously are superior to vitamin C and vitamin E.Zoopery is the result show; Take mouth to feed or intraperitoneal injection; GTPs can improve the vigor (P＜0.05) of SOD (superoxide dismutase) in blood GSH-Px (glutathion peroxidase) vigor (P＜0.01) regulating liver-QI of white mice; Reduce the content of LPO in liver and the serum, delay the formation (P＜0.01) of myocardium LF.Rat exists 60Mouthful feed GTPs before and after the CO roentgenization, GSH-Px and the SOD in its whole blood all be significantly increased (P＜0.01).[5] such as Guo Q adopt xanthine (x) and xanthine oxidase (xo) to produce the external model of reactive oxygen free radical; Utilization ESR method and BCL method find that GTPs has the ability of very strong removing reactive oxygen free radical; Wherein the efficient of EGCG elimination activity oxygen-derived free radicals reaches 98%, is about ascorbic 4 times.Yang Xianqiangs etc. [6] find that EGCG and organic acid (like malic acid, citric acid etc.), vitamin E, vitamin c have synergism, and stronger than the BHT antioxidation of vitamin c and synthetic in the anti-oxidation research of becoming sour of Adeps Sus domestica.Resistance to oxidation intensity etc. molar concentration is followed successively by: EC＜ECG＜EGC＜EGCG.Yet; Shen Shengrong etc. [7] report; GTPs can produce oxygen-derived free radicals and Polyphenols semiquinone radical anion under external alkali condition; Wherein the generation ability of EGCG is better than tea polyphenols complex, and this characteristic of GTPs possibly be the essence of toxigenicity reaction when high concentration, is to remove the reason that the free radical effect weakens under the high concentration.Thereby the unsuitable overdose use of prompting: GTPs, in order to avoid remove the ability drop of free radical and toxic and side effects is strengthened.Lei Yaoxing etc. [8] report, purified GTPs and EGCG etc. are added to test relatively their non-oxidizability in the Oleum Arachidis hypogaeae semen.The result shows that non-oxidizability is relevant with the amount of test temperature, additive.Under the room temperature, addition is the GTPs of 0.4g/L relatively in Oleum Arachidis hypogaeae semen, and through the experimental observation of 277d, the oxidation suppression ratio is up to 68.3%.Chen Yaoming etc. [9] report, Folium Camelliae sinensis and fortified zinc all have potentiation to rat muscle power and lipid peroxidation.
[list of references]
1. the green English of Chen Yu spring king. the immune drug action progress that tea is treated. Chinese Chinese medicine information magazine .1999.006 (012) .26-28
2. Li Ping Li Zhen. immunostimulant-tea polyphenols. veterinary drug and feed additive .2003.008 (005) .19-21
3. the auspicious Han Chi of Zhu Mao. tea is to the protective effect of immune function of mice. Chinese Journal of Preventive Medicine .1998.032 (005) .270-274
4 Yang Xianqiangs, Cao Mingfu, Shen Shengrong, etc. the research of tea polyphenols BA. tea science, 1993,13 (1): 51
5GUO?Q，Zhao?B，Li?M，et?a1.Studies?on?proetctive?mechanisms?of?four?components?ofgreen?tea?polyphenols?against?lipid?peroxidation?in?synapto-Somes[J].Bioehim?Biophys?Acta，1996，1304(3)：210
6 Yang Xianqiangs, Shen Shengrong, Hou Jingwu, etc. epigallocatechin gallate (EGCG) is to the scavenging action mechanism of reactive oxygen free radical. Acta Pharmacologica Sinica, 1994,15 (4): 350
7 Shen Sheng are flourish, Yang Xianqiang, and Zhao Baolu, etc. the external free radical mechanism [J] that helps Oxidation of tea polyphenols. tea science, 1992,12 (2): 145
The credit of 8 thunders is emerging, Li Deyong, Yang Banghuan. the extraction of catechu and Study on oxidation resistance thereof [J] in the green tea. and Guangxi Medical College's journal, 1992,9 (3): 45
9 Chen Yao are bright, Chen Jingyuan, and Gao Shuanbin, etc. Folium Camelliae sinensis and fortified zinc are to the influence [J] of rat muscle power and lipid peroxidation. the 4th military region college journal, 2000,21 (1): 128
There is an ancient Chinese scholartree in solid residential district, [Sophora japonica L.] She County, Hebei province, is known as peerless Chinese scholartree.This old pogada tree is high 29 meters, and tree encloses 1.7 meters, 19 meters of hat width of cloth diameters, about about 2000 of the age of tree.The ancient Chinese scholartree of this strain though suffer invasion and attack of the Nature and wrecking of the flames of war repeatly, is gone through vicissitudes in thousand, but still is growing vigorously with its vigorous vitality.Sophora japonica L. sophorajaponicaL. is a leguminous plant; Its flower contains globulariacitrin (a type of organic compound; Various organic compound condensations by saccharide and non-saccharide form); Alabastrum content is the highest, from alabastrum, obtains triterpenoid saponin, after the hydrolysis betulin (betulin), sophoradiol, glucuronic acid (aldehyde quan organic compound one type).The Fructus Sophorae contains 9 kinds of flavonoids and isoflavonoid, rutin, plain (sophorin), Mongolian oak (hu deciduous tree) Pi Su of Fructus Sophorae (querentin) etc.Globulariacitrin has inhibitory action to some transplantation tumor.Fructus Sophorae seed extracting solution contains exogenous phytohemagglutinin (PHA), and this material can improve immunity, and the effect of active anticancer is arranged.Experiment in vitro, the hot water extract of the Fructus Sophorae to the human cervical carcinoma cell suppression ratio more than 90%.Clinically be used to treat digestive system tumor, cervical cancer, rectal cancer etc." book on Chinese herbal medicine justice ", commodity are claimed " Flos Sophorae Immaturus ".Bitter in the mouth, cool in nature.Return liver, large intestine channel.Function: heat clearing away, removing heat from blood, hemostasis.Cure mainly: under discharging fresh blood stool, hemorrhoidal bleeding, hematuria, stranguria with blood, metrorrhagia, nosebleed (the nv nostril is hemorrhage) blood, the dysentery with red and white feces, wind heat conjunctival congestion, carbuncle (ju controlling partially skin turgor is hard and skin infection that color of the leather is constant) sore.And be used for prevention of stroke.Pharmacopeia is recommended consumption 5～9g.Modern according to 1. auxiliary lipid-lowering functions; 2. aided blood pressure-lowering function.
Modern study shows that Mel can improve nutriture, promotes skin metabolism; Strengthen the vigor and the antimicrbial power of skin, reduce pigmentation, prevent xerosis cutis; Make skin soft, pure white, fine and smooth, and can reduce wrinkle and prevent and treat dermatopathy such as acne, play ideal skin maintenance effect.The contained nutrient substance of Mel is very abundant.Scientist confirms, has found to contain all listed in mendeleev periodic table of elements trace element in the Mel.Saccharide in the Mel accounts for 3/4ths of total composition, and wherein fructose and glucose account for 85%～95% of total sugar amount again.The vitamin that contains in the Mel mainly is b vitamin and vitamin c.Therefore, Mel has comparatively ideal cosmetic result just not strange.Mel has very strong bactericidal action, makes it can protect skin, cleaning skin and some skin diseases of treatment and wound.Mel is the sugar juice of high concentration, and a lot of mushrooms are had inhibitory action; Reason is the glucose peroxidase that contained to act on glucose, produces hydrogen peroxide, and certain density hydrogen peroxide has antibacterial and bacteriostasis.Wherein fructose content is very high in the Chinese scholartree honey, the utilization that very easily is absorbed by the body, and the ability that fructose is transformed into fat is teenager and old people's ultimate food less than glucose; Also contain acaciin and volatile oil in the Chinese scholartree honey, can antibiotic, anticorrosion and cough-relieving.
There is the jujube tree in more than 1300 year of survival in mud stream, Zhu Jiawa township, [jujube tree] Jia County, Yulin village, and this tree was planted the Tang Dynasty, 3.3 meters of tree trunk girths, and tree is divided two, and is high more than 8 meters, annual 50 kilograms of the Fructus Jujubaes that produce.Fructus Jujubae includes materials such as saccharide, protein, fat, starch, multivitamin and carotene, organic acid, calcium, phosphorus, ferrum, potassium, sodium, magnesium, iodine.Do the cutter sugar content up between the 60%-80%, also higher than the content of sugaring raw material Caulis Sacchari sinensis and Radix Betae, ascorbic content comes out at the top in fruit, and is higher about 100 times than Fructus Mali pumilae, Fructus Persicae, than the high 7-10 of Fructus Citri tangerinae times.The Britain physician did once experiment at 163 weakly philtrums, and the result eats the people of Fructus Jujubae continuously, and the healthy speed of recovering is faster more than three times than the people who singly eats various vitamin, so he says that Fructus Jujubae is the " vitamin pill of living.From ancient times to the present, Fructus Jujubae all is to nourish the good medicine of curing the disease simply, and its sweet in the mouth property is flat, and the traditional Chinese medical science always is regarded as moistening tonic to it.And Rhamnaceae jujube Ziziphi Spinosae kernel contains jujuboside A, B etc.The property flat, sweet in the mouth, acid have the effect of tranquilizing by nourishing the heart, tonifying liver, arresting sweating.Cure mainly symptoms such as vexed insomnia, palpitation with fear palpitation with a distress feeling (traditional Chinese medical science refers to cardiopalmus), weak hyperhidrosis, neurasthenia, dreaminess, the few xerostomia in Tianjin.Modern pharmacology proves, effect such as Semen Ziziphi Spinosae has calmness, hypnosis, bring high blood pressure down.Same Flos Jujubae Mel nutritional labeling is also very important, has invigorating the spleen and replenishing QI nourishing blood to tranquillize the mind blood-enriching face-nourishing strengthening the spleen and nourishing the stomach effect.
On the savanna of Africa arid, the big tree that a kind of shape of growing is peculiar---its Bo Babu that is named as sets [monkey-bread tree].Because monkey and Arabic Canis familiaris L. face baboon all like eating its fruit, so people claim that it is " monkey-bread tree ".Monkey-bread tree still is famous hollywood lignumvitae, even in the adverse circumstances of the sort of arid of savanna, its life-span still can reach about 5000.Monkey-bread tree, whole body all are that medical material fruit, leaf and bark can both be used as medicine, can antiinflammatory, bring down a fever, the treating malaria disease.Monkey-bread tree is precious from head to foot.Its fresh and tender leaves is the vegetable that the locals extremely likes.Leaf can be cooked soup, and seed can be stir-fried and eaten.Sarcocarp is edible or process beverage.Fruit, leaf and bark can be used as medicine, and nourishing the stomach function of gallbladder promoting, clearing heat for detumescence, hemostasis antidiarrheal effect are arranged, and also contain the material that the opposing stomach cancer cell forms and spreads.It also once was used to treat malaria, played antipyretic effect.The serosity of its leaves and fruit is local anti-inflammation drugs commonly used.
[PiceameyeriRehd. Et Wils. tree] PiceameyeriRehd. Et Wils. is Chinese endemic tree, is distributed as extensively with the mountain region, North China, and also there is distribution on ground such as the Xiaoxinanlin Mountains in northeast.The PiceameyeriRehd. Et Wils. of Sweden's discovery in recent years lived more than 9550 year.PiceameyeriRehd. Et Wils. is the how resinous and volatile oil of pinaceae plant.In addition, " general Xie Erman " that be arranged in Chinese larch national park, Nevada ,Usa mountain has the age of tree in 3200 at least, also might reach 4000 years.Wherein the PiceameyeriRehd. Et Wils. seed is very important nutrient substance.
[Folium Dracaenae cambodianae] 1868, famous geographer flood fort moral be when in a moment his island is investigated in Africa, found the age plant venerable old man or lady up to 8000 years old.Unfortunately this tree is fractureed by the tempest of firm generation.Also just because of it by the storm trunk that fractureed, big vast fort moral can be known its accurate age through the annual ring of its trunk breaks of number.The Folium Dracaenae cambodianae growth is very slow, and the centuries just can grow up to one tree, just opens decades once and spends, and is therefore very precious rare.Yunnan Province of China and Guangxi all have.Nature and flavor with return through sweet, hot, salty, warm, return lung, spleen, kidney channel.Function with cure mainly: promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, expelling pus and promoting granulation.Be used for traumatic injury, blood stasis is had a pain, women's coagulation of QI-blood, and traumatic hemorrhage, abscess does not close up for a long time.According to the Compendium of Material Medica record, Sanguis Draxonis is warm in nature, flat, and sweet in the mouth, salty is nontoxic, goes into blood system, returns lung, spleen, kidney three warps, has blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, astringing to arrest bleeding, remarkable efficacy such as hard masses softening and resolving, promoting tissue regeneration and ulcer healing.Modern medicine study confirms, dragon's blood capsule has the body of improvement microcirculation, adjustment body metabolism, improve effect such as body's immunity.1. improve the body microcirculation, endocrine regulation.Blood circulation promoting and blood stasis dispelling increases the body intravascular coagulation factor, and bleeding patients is had remarkable anastalsis, having dual regulation aspect the treatment traditional Chinese medical science mass formed by blood stasis, enhances metabolism, and quickens lymphatic return; 2. contain the Sanguis Draxonis Saponin, the effect that has powerful anti-inflammatory and antalgic and improve body's immunity; 3. containing antibiotic preservative substance---plant defense is plain, has the effect of putrefaction-removing granulation-promoting; 4. regulating menstruation treating blood disorders, hard masses softening and resolving, blood-activating and qi-promoting.The traditional Chinese medical science is thought, qi being the governor of blood, and blood being the material foundation of QI, the capable then blood of gas is capable, and the capable then stasis of blood of blood is gone, the prosperous blood clots absorbing of gas ruton, all diseases must be healed naturally.
Below be the brief introduction that has enhancing immunity, slow down aging, looks improving and the skin nourishing effect material adjuvant to selected:
[Radix Ginseng] Radix Ginseng has the postponement cell ageing, prolongs the function of cell survival.The main component of Radix Ginseng adjustment aging course and prevention senilism is the ginsenoside; It mainly acts on is the low physiological system of stimulatory function; Its biochemical reactions is tending towards normally, and stops the vicious cycle that causes owing to a variety of causes, to reach the life lengthening purpose.The antioxidation of Radix Ginseng is one of important step of Radix Ginseng anti-aging effects.
That [Ganoderma] Ganoderma just is considered to since ancient times is lucky, rich and honour, fine, the life-prolonging symbol, has " Herba mesonae chinensis ", the title of " Ganoderma ", chinese tradition medical science is regarded as strengthening by means of tonics for a long time always, consolidates the precious Chinese herbal medicine of setting upright.Ganoderma is the treasure in motherland's pools of traditional Chinese medicine, have the reputation of " Herba mesonae chinensis ".Pharmacology and clinical research at all times proves that all Ganoderma truly has and prevents and cures diseases, the effect of life lengthening.The Compendium of Material Medica of the Shennong's Herbal of the Eastern Han Dynasty, the famous medical scholar's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty, all the effect to Ganoderma has detailed very sure record.Modern pharmacology and clinical practice have further confirmed the pharmacological action of Ganoderma, and confirm that ganoderan is the main component of Ganoderma strengthening the body resistance, strengthening by means of tonics, life lengthening.Now, Ganoderma is formally recorded by NF as medicine, and it is again the new resource food of state approval simultaneously, has no side effect, can medicine-food two-purpose.Scientific research shows; The pharmaceutical component of Ganoderma is very abundant; Wherein active ingredient can be divided into ten big types; Comprise ganoderan, Ganoderma polypeptide, triterpenes, 16 seed amino acids (wherein containing seven kinds of essential amino acids), protein, steroid class, mannitol, coumarin glycosides, alkaloid, organic acid (the main Fumaric acid that contains), and trace element Ge, P, Fe, Ca, Mn, Zn, etc.Ganoderma has dual regulation to human body, and the kind of curing the disease relates to each systems such as cardiovascular and cerebrovascular vessel, digestion, nerve, endocrine, breathing, motion, and is especially very remarkable to the preventive and therapeutic effect of tumor, hepatic lesions, insomnia and aging.The range of application of Ganoderma is very extensive.See with regard to differential diagnosis in tcm, because these article go into the five internal organs kidney tonification whole body QI of five ZANG-organs, so no matter a little less than the heart, lung, the liver,spleen,kidney deficiency of five ZANG-organs, all can obey it.Ganoderma is cured the disease to plant and relates to each systems such as breathing, circulation, digestion, nerve, endocrine and motion; Contain inside and outside, woman, youngster, each section's disease of face.Its basic reason just is the Ganoderma strengthening the body resistance, raise immunity, the huge effect that improves Abwehrkraft des Koepers.It is different from general medicine and certain disease is played therapeutical effect; Also being different from general nutritional health food only replenishes and strengthens the deficiency of nutrient in a certain respect; But two-ways regulation function of human body balance is on the whole transferred the internal body vigor, regulates human body metabolism function; Improve the autoimmune ability, impel whole internal organs or organ function normalization.
Why the people can wear out, flag, skin tarnishes and elasticity, and except age growth was irresistible factor, one of main factor was that interior free yl is too much.At an early age, there is preferably neutralising capacity get rid of free radical in the body, reduces the injury that it causes; Yet with advancing age, human body is repaired the also decline thereupon of ability of radical damage; If fail in time to replenish polyphenoils, cell receives radical damage more easily, so disease will produce.More and more evidences shows that interior free yl content is high more, and the life-span is short more.
Chen Ling [1]SOD appearance activity to glossy ganoderma mycelium fermentation liquid is measured, and compares with the sporophore extracting solution, studies it to the active influence of an experiment mice erythrocyte SOD.The result shows: it is active that fermentation liquid and extracting solution not only have SOD appearance, and behind continuous irrigation stomach 12d, and the activity of SOD is respectively to 2.56 times and 1.95 times of matched group in the mouse red blood cell.The result shows that the defying age mechanism of Ganoderma mainly works with the removing free radical through improving the body activities of antioxidant enzymes.
Guo Fang [2]Observe Ganoderma fermentation liquid to the free radical relevant enzyme of old and feeble rat due to old and feeble rat, the D-galactose and the influence of metabolite, cerebral cortex ultrastructure, erythrocyte membrane and sexual function.1. method chooses 24 monthly age SD rats, measures the various dose Ganoderma fermentation liquid to blood and/or cerebral tissue total antioxidation vigor, vitamin C, malonaldehyde, the activity of glutathion or the influence of content.2. SD rat; Divide 6 groups at random; Be respectively blank group, model control group, Ganoderma fermentation liquid (0.3,0.6,1.2g/kg), vitamin E 0.8g/kg group, except that the blank group, each organizes equal subcutaneous injection D-galactose 50mg/kg/d; Measure activity or the content of SOD, MDA, GSH-Px, MAO, LPF in blood and the cerebral tissue, and through the Ultrastructural variation of transmission electron microscope observing cerebral neuron.3. observe the influence of Ganoderma fermentation liquid to mda content on the erythrocyte membrane.4. observe Ganoderma fermentation liquid to erection incubation period, pounce on and catch incubation period, pounce on the influence of catching number of times, ejaculation frequency, ejaculation latency.Result 1. Ganoderma fermentation liquid 1.2g/kg can obviously improve total antioxidation vigor and content of ascorbic acid, reduces MDA content, and glutathion is not had obvious influence.2. the Ganoderma fermentation liquid 0.3g/kg activity of GSH-Px that can raise reduces the content of MDA, LPF, and other relevant enzyme and metabolite is not had obvious influence; 0.6g/kg group can reduce the content of LPF, MDA, increases the activity of SOD in the serum; 1.2g/kg can make SOD, the active rising of GSH-Px, reduce MDA and LPF content, also can suppress the activity of MAO.But the Ganoderma fermentation liquid dose dependent alleviate the neuronal degeneration that the D-galactose causes.3. Ganoderma fermentation liquid 0.6,1.2g/kg group can make erythrocyte membrane MDA content obviously reduce, and the 0.3g/kg group does not then have obviously influence.4. Ganoderma fermentation liquid 1.2g/kg can shorten erection incubation period, and 0.6g/kg obviously increases to pounce on and catches number of times and ejaculation frequency, shortens to pounce on and catches incubation period and ejaculation latency, and the 0.3g/kg group only shortens to pounce on catches incubation period.Conclusion glossy ganoderma fermentation fluid power improves the D-galactose and causes the brain Change of Ultrastructure through formation that suppresses MDA and/or the activity that improves antioxidase, has significant antioxidant role, and sexual function is had certain influence.
Cui Yuehua [3]After in glossy ganoderma fermentation substrate, adding Folium Ginkgo, Semen Coicis, measure the scavenging action and the reducing power of the superoxide anion of its tunning hydroxy radical that reaction generates to Fenton and the generation of pyrogallol autoxidation.The result shows that half suppression ratio of removing hydroxy radical is respectively Ganoderma 90 μ L, is 86 μ L behind the interpolation Folium Ginkgo; Adding behind the Semen Coicis is that half suppression ratio that 77 μ L. remove superoxide anion is respectively Ganoderma 1.7mL, is 1.62mL after adding Folium Ginkgo, and adding behind the Semen Coicis is 1.5mL, when 100 μ L; Three's reducing power is respectively: Ganoderma is 0.076; Adding behind the Semen Coicis is 0.084, and adding behind the Folium Ginkgo is 0.102, be illustrated in remove free radical and reducing power side and; Ganoderma is better than the effect of the independent fermentation of Ganoderma to Semen Coicis and Folium Ginkgo fermentation back, and Semen Coicis and Folium Ginkgo have invigoration effect to the effect of external removing free radical of Ganoderma and reducing power aspect.
Analogy south is intelligent [4]Inquire into ganoderma lucidum triterpene compounds (GLT) effect; To be divided into 8 groups through 80 qualified of SD rats of Morris water maze screening; Normal control group, sham operated rats; Model group, GLT basic, normal, high (GLT0.25,0.5,1.0g/kg) dose groups, positive drug group (brain-invigorating capsule group 0.54g/kg) and solvent group (edible oil 10ml/kg), except that normal control group and sham operated rats, all the other are respectively organized rat and prepare the AD rat model through intracerebroventricular injection A β 25-352 μ l; Normal control group intracerebroventricular injection equivalent normal saline, postoperative begin gastric infusion next day.Every day 1 time, behind the successive administration 20d, the execution animal is got cerebral tissue and prepares homogenate.Adopt photochemical method to detect catalase (CAT), Acetylcholinesterase (ACHE), superoxide dismutase (SOD) activity and malonaldehyde (MDA) content in the brain homogenate.The result: compare with the normal control group, CAT is active in the model group cerebral tissue reduces, and ACHE is active to raise, and the SOD activity reduces, and MDA content raises.Compare with model group, in three GLT administration group cerebral tissue, the CAT vigor all raises, and the ACHE vigor all descends, and the SOD activity all raises, and MDA content all reduces.Conclusion: ganoderma lucidum triterpene compounds has the ability of removing free radical that strengthens to the AD rat model, the recovery of anti peroxidation of lipid and promotion cholinergic nerve system function.
The Zhang Yue [5]Observe the influence of ganoderma lucidum triterpene compounds (GLT) to D-galactose (D-gal) aging model ability of learning and memory in mice and oxidation resistance.Method 5%D-gal subcutaneous injection is set up the mouse aging model, irritates stomach simultaneously and gives GLT, and normal control group and model group give the equal-volume normal saline.Detect learning and memory abilities in aging mice with the Morris water maze laboratory, biochemical process detects mouse brain and organizes TAC (T-AOC), superoxide dismutase (SOD) vigor and malonaldehyde (MDA) content.The result compares with the normal control group, and the model group ability of learning and memory in mice reduces, cerebral tissue T-AOC, S01) vigor decline, MDA content increases.After the filling stomach gave GLT, the above-mentioned variation of mice obviously improved.Conclusion GLT can improve D-gal aging model learning and memory abilities in aging mice, has to promote intelligence and function in delaying senility, and its mechanism maybe to have oxidation resistance relevant with GLT.
Shi Yali [6]The research ganoderan exhausts the influence of mouse cardiac muscle, liver, skeletal muscle antioxidation to power.Method: measure behind the mouse stomach ganoderan 20d: the variation that quiet mice glutathion peroxidase (GSH-Px), superoxide dismutase (SOD) are active, power exhausts mouse cardiac muscle behind the swimming exercise, liver, skeletal muscle malonaldehyde (MDA) level and serum glutamic pyruvic transminase (GPT), glutamic oxaloacetic transaminase, GOT (GOT), creatine kinase indexs such as (CK).The result: ganoderan can obviously improve mice skeletal SOD and myocardium GSH-Px is active, and obviously reduction power exhausts mice skeletal MDA level and serum GPT and CK level, alleviates liver and skeletal muscle and decreases.
Zhang Jue [7]Investigated the ultrafiltration and concentration alcohol deposition method and extracted the fermentation glossy ganoderma mycelium polysaccharides, compared with the concentrating under reduced pressure method, polyoses content, polysaccharide yield all are higher than the latter, and the quality of gained polysaccharide is improved, and has alleviated the burden of follow-up polysaccharide purification.The Ganoderma mycelium crude polysaccharides has the ability of removing preferably to hydroxy radical OH (HFR), and clearance rate and polysaccharide concentration are proportionate within the specific limits, and the OH clearance rate that the ultrafiltration and concentration alcohol deposition method extracts the Ganoderma mycelium polysaccharide is higher than the concentrating under reduced pressure alcohol deposition method.
Shao Huaqiang [8]The anti-aging effects of checking Ganoderma is also studied its mechanism of action.Method:, Ganoderma has been carried out the serum superoxide dismutases test of aged mouse according to Ministry of Public Health " the health food function assessment assessment process and the method for inspection ".The existence test of lipid peroxide test and fruit bat.The result: Ganoderma can obviously strengthen the activity of the serum superoxide dismutases of aged mouse.Reduce the content of lipid peroxide in the aged mouse serum, prolong the life-span of fruit bat, conclusion: Ganoderma has certain anti-aging effects.
Chen Guanmin [9]Understand the delaying senility function of Ganoderma extracting solution to animal." method " adopts the experimental technique of drosophila survival and old mouse-anti Oxidation." result " Ganoderma extracting solution can obviously prolong the average life and average maximum life span of fruit bat; Can obviously reduce lipid peroxide catabolite malonaldehyde (MDA) content in the blood, increase superoxide dismutase in the blood (SOD) vigor." conclusion " Ganoderma extracting solution has delaying senility function.
Qin Kui [10]Be the basis with domestic a large amount of representational document in recent years, and consult external related data that analyze, put in order and conclude, according to its medicinal part, main component is commented respectively.The result: the Ganoderma decocting extracts preparation, Ganoderma fermentation liquid, Ganoderma spore powder, ganoderan and some Ganoderma albumen etc. and all has significant immunological enhancement and immune restoration effect, and certain immunosuppressive action is also arranged simultaneously.Wherein, more to the research of ganoderan, especially comparatively deep to the immunization research of its cell and cytokine, illustrated the mechanism of Ganoderma immunoregulation effect basically, disclose the reason of Ganoderma " strengthening by means of tonics, strengthening the body resistance ".This distinguishes the flavor of rare old medicine aspect human body immunity improving function, inhibition immunologic injury, health invigorating, disease preventing and treating the conclusion Ganoderma, has wide research and development application prospect.
Cao Jing [11]Observe of the dynamic adjustments effect of Ganoderma fermentation liquid polyoses extract, inquire into its antitumor mechanism S180 tumor-bearing mice partial immunity index.Method: 80 of S180 oncocyte lotus tumor kunming mices are set up animal model; Respectively 40 of normal saline group (NS group) and Ganoderma fermentation liquid polysaccharide groups (GFG group) are respectively at after the lotus tumor the 4th, 7; 10; 13,16 days every group put to death 8 mices, detect the influence of GFG to NK cytoactive, lymhocyte transformation rate.Result: GFG can significantly improve tumor-bearing mice NK cytoactive and lymhocyte transformation rate.With lotus tumor time lengthening, the GFG group can be kept higher level (P＜0.01) than the NS group, but totally on a declining curve.Conclusion: the Ganoderma fermentation liquid polyoses extract can significantly improve NK cytoactive and lymhocyte transformation rate, and keeps certain level.
Lu Zhen [12]The research Ganoderma mycelium is to mouse immune liver damage and Immune Effects.Method: adopt bacillus calmette-guerin vaccine (BCG)+inductive immunologic liver injury model of lipopolysaccharide (LPS), cyclophosphamide (Cy) induced mice delayed hypersensitivity (DTH) increases or low drag and ConA (ConA) or lipopolysaccharide (LPS) induction of lymphocyte multiplicative model are observed.The result: Ganoderma mycelium (0.9g/kg, qd * 10d, Serum ALT (P＜0.01), AST (P＜0.05) and the index and spleen index that 1g) the immunologic liver injury mice is raise low (,＜0.05), and the damaging variation of mouse liver is alleviated.The Ganoderma mycelium one side (0.3,0.6,0.9g/kg, ig, qd * 5d) can suppress hyperfunction mouse cell immunologic function makes mouse DTH alleviate (P＜0.05, P＜0.01 and P＜0.01); On the other hand (0.6,0.9g/kg, ig, qd * 5d) also can improve low mouse cell immunologic function makes mouse DTH strengthen (P＜0.05 and P＜0.01).And, Ganoderma mycelium (0.3,0.6,0.9g/kg, ig, qd * 10d) can suppress the inductive T lymphopoiesis of ConA ConA (P＜0.05, P＜0.01 and P＜0.01).Conclusion: Ganoderma mycelium has the cellular immunization regulatory function, and immunologic liver injury is had the significant protection effect.
[list of references]
1. Chen Ling Zhai Xiao is shady. and Ganoderma fermentation liquid is to the active influence of SOD in the mouse red blood cell. the journal .1997 of Shanghai Communications University 31 volume 4 phases: 90-92
2. Guo Fang Qiya is beautiful. and Ganoderma fermentation liquid is to the research of old and feeble rat anti Oxidation and sexual function thereof. the journal .2005 of Third Military Medical University 27 volume 15 phases: 1564-1568
3. Cui Yue spends Xu Peng Zhang Kechang. the research of the effective product antioxidation activity in vitro of Ganoderma liquid fermentation. and food and fermentation industries .2006 32 volume 8 phases: 32-34
4. analogy south is intelligent. and ganoderma lucidum triterpene compounds is to CAT in the AD rat model cerebral tissue, ACHE, SOD, the influence of MDA. Guiyang Medical College journal .2008 33 volume 6 phases: 640-642,651
5. open the intelligent Zhang Xiaoyi of the yellow ability of Yue. ganoderma lucidum triterpene compounds is to the effect of aging model learning and memory of little mouse. Shanghai Communications University's journal: medicine .2007 27 volume 8 phases: 969-971
6. Shi Yali Liu Yun is auspicious. and ganoderan exhausts the research of mouse anti lipid peroxidation to power. modern preventive medicine .2006 33 volume 6 phases: 889-890
7. open two pieces of jade put together Zhang Kechang. the ultrafiltration extraction and the Study on Antioxidant Activities thereof of lucidum mycelium polysaccharide. chemistry world .2006 47 volume 1 phase: 33-35
8. the strong Lu Lian of Shao Hua is magnificent. the Ganoderma experimental study about anti-senility. and the journal .2002 of Shandong Traditional Chinese Medicine University 26 volume 5 phases: 385-386
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11. the precious Ning'an of Cao Jing Xu Yu is red. the Ganoderma fermentation liquid polyoses extract dynamic observes the tumor-bearing mice cellular immunization. Chinese microecology magazine .2004 16 volume 3 phases: 140-141,143
12. Lu Zhen Chen Jin with. the fermentation glossy ganoderma mycelium is to mouse immune liver damage and Immune Effects. the time precious traditional Chinese medical science traditional Chinese medicines .2004 15 volume 4 phases: 214-216
[Radix Polygoni Multiflori] includes phenolic compound, and root contains chrysophanol, emodin, chrysophanic acid, in addition, and starch-containing 45.2%, crude fat 3.1%, lecithin 3.7% etc.The Chinese medicine theory is thought; The Radix Polygoni Multiflori nature and flavor are bitter, sweet, puckery; Tepor; Effect such as have tonifying liver, kidney tonifying, nourish blood, dispel the wind is applicable to diseases such as hepatic and renal YIN deficiency, early whitening of beard and hair, blood deficiency dizziness, soreness of the waist and knees, muscles and bones are ached, seminal emission, metrorrhagia and leukorrhagia, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, hemorrhoid, lupus erythematosus.Modern medicine confirms that the anthraquinones in the Radix Polygoni Multiflori has effects such as cholesterol reducing, blood sugar lowering, antiviral, heart tonifying, promotion gastrointestinal peristalsis, promotes the FA effect in addition, and cardiovascular and cerebrovascular disease is had certain preventive and therapeutic effect; Contained lecithin is the component of cerebral tissue, hemocyte and other cell membrane in the Radix Polygoni Multiflori, and often edible Radix Polygoni Multiflori has therapeutical effect to diseases such as neurasthenia, poliosis, alopecia, anemias, therefore, and delaying sanility, building body, health care heart.
The Flos Nelumbinis of [Flos Nelumbinis pollen] Flos Nelumbinis pollen is one of ten big famous flowers of China, and it is large flower and brilliant color not only, and delicate fragrance is far excessive, the Cui Gai that rides the waves, and extremely strong adaptability is arranged, and in the modern landscape gardens of today, more receive people's favor, use more extensive." lotus " is called as " living fossil ", is one of origin plant the earliest in the angiosperm.Century-old on its seeds, still can plant.Before the mankind occurred, before about 100,004,000 quincentenaries, big of the earth was covered by ocean, lake and marsh.At that time, awful weather, disaster does not frequently have animal, and most of plant is eliminated, and has only the extremely strong wild plant of minority vitality to be grown on this barren earth.Wherein, have a kind of today we be called the water plant of " Flos Nelumbinis ", withstood the test of the Nature, the Amur in China survives in the swampy lake in modern Heilungkiang, the Yellow River, the Yangtze river basin and the Northern Hemisphere tenaciously.Approximately spent 9,000 years, the hominid begins to occur.Human in order to survive, gather wild fruit and allay one's hunger, just find the wild fruit and the Gen Jie of this " Flos Nelumbinis " soon, promptly Semen Nelumbinis and Rhizoma Nelumbinis are not only edible, and sweet delicate fragrance, and be delicious good to eat.Gradually, the grain of " Flos Nelumbinis " this human survival source just stamp dearly at us ancestors---the hominid becomes the symbol of human survival in the heart.
[Tremella] Mycophyta Tremellaceae Tremella plant is claimed Tremella, Tremella, Tremella etc. again.Property is put down, sweet in the mouth, light, nontoxic.The nutritional labeling of Tremella is quite abundant, in Tremella, contains protein, fat and several amino acids, mineral and glycogen.Contain 17 seed amino acids in the Tremella protein, 3/4 Tremella in the necessary aminoacid of human body can both provide.Tremella also contains several mineral materials, and like calcium, phosphorus, ferrum, potassium, sodium, magnesium, sulfur etc., wherein the content of calcium, ferrum is very high, in every hectogram Tremella, and 643 milligrams of calcics, 30.4 milligrams of ferrum.In addition, also contain glycogen such as trehalose, pentosan, mannitol in the Tremella, nutritive value is very high, has the strong effect of setting upright, and is a kind of senior nourishing tonic.
Summary of the invention
Through above analysis, we know that " alive for evermore " tree and other herbaceos perennial life-prolonging profoundness are to exist in its body longevity gene of crucial importance, very abundant nutrition composition and chemical constituent.They are just as being natural high-tech machine, " adopt the anima in the world, get the elite of all things on earth ", and impersonal force institute could be for also! Just there are nutritional labeling and chemical constituent more than 160 kinds like the slight Folium Ginkgo of a slice; A small pollen just has 200 multiple nutritional components; Especially contained flavonoid and terpenoid lactone chemical compound; Can effectively remove killer's free radical of human body cell, suppress cell membrane lipid peroxidation, play slow down aging.Exist as hollywood lignumvitae on the earth since I think, " alive for evermore " life since the people is identical with the vital signs of tree, since all biologies can both will convert the ingredient of cell through metabolism from the nutrient substance in the external world into.The people has only long-term absorption " to adopt the anima in the world, get the elite of all things on earth " the synthetic natural nutrient component of tree alive for evermore so, help people enhancing immunity, slow down aging, looks improving and the skin nourishing that could be real.This is to be based upon the fact and the people of " alive for evermore " tree and to set on the vital signs scientific evidence basis in like manner.Because more than 3000 year existing ginkgo, fox-brush pine in 4769 and " the bright and beautiful elegant tea ancestral " tree in more than 3200 year, why " alive for evermore " is because the nutritional labeling that forms the gene of the interior congenital heredity of its body and the day after tomorrow after all.
For reaching above-mentioned intended purposes, the technical formula that the present invention taked is: oleo stock wine, PiceameyeriRehd. Et Wils. seed, Sanguis Draxonis, Semen Platycladi, Pollen Pini, Semen Ginkgo, Semen Ginkgo pollen, Flos Camelliae Japonicae powder, Flos Nelumbinis pollen, Radix Ginseng, Ganoderma, Radix Polygoni Multiflori, Poria, Tremella, Mel and Flos Rosae Rugosas pollen, Flos persicae, Flos Jasmini Sambac.The invention has the beneficial effects as follows: enhancing immunity, slow down aging, looks improving and the skin nourishing.
The specific embodiment
(1) its production technology sketch is following:
Figure G2009100935732D00231
(2) specify as follows:
(1) sealing is soaked: at first will pass through PiceameyeriRehd. Et Wils. seed, Sanguis Draxonis, Semen Platycladi, Pollen Pini, Semen Ginkgo, Semen Ginkgo Flos Nelumbinis pollen, Radix Ginseng, Ganoderma, Radix Polygoni Multiflori, Poria, Tremella, Mel and Flos Rosae Rugosas pollen, Flos persicae, the Flos Jasmini Sambac of anticipating and add proper amount of edible ethanol with the oleo stock wine in proportion and seal immersion 30 days at normal temperatures.
(2) essence is blent
Requirement and characteristic by product standard are allocated above-mentioned each extracting solution and high-quality oleo stock Sucus Vitis viniferae by a certain percentage, the concordance of the product quality that keeps dispatching from the factory.To carry out suitable adjustment to its composition simultaneously, to reach the requirement of standard.
(3) cold preservation clarification
Above-mentioned supernatant (both extracting solution) is sealed the back at 48 hours clarifying treatment precipitate of cold room cold preservation.
(4) filter
In whole technical process, need separating for several times precipitate and dregs, all need filter at every turn.Filtration be with contain suspend or the old wine of selecting material under the effect of certain motive force, through filter medium, make suspend or the deposition microgranule be trapped within medium above, and the clarifying extracting solution that from pore, passes through.Require difference according to each technical process, filtration is divided into coarse filtration, clarification filtration, aseptic filtration etc.
(5) filtering extracting solution is done further clarifying treatment precipitate in cold room cold preservation.
(6) intermediate survey
Indexs such as the color of check extracting solution, clarity.After the assay was approved could fill.
(7) fill
Fill in time after the extracting solution clarifying treatment, fill comprises operations such as wash bottle, bottling, cleans up filling apparatus and liquid-transport pipe-line and fill glass bottle with hot water.By specification canned and capping on automatic filling machine.
(8) cleaning, decals
Cleaning possibly overflowed the extracting solution outside the bottle in pouring process.Dry the back decals.Decals will guarantee to be printed on the label signs such as batch number, date of manufacture, shelf-life.
(9) outer package
Get through the qualified housing material of quality inspection.Carry out outer package, dress carton, big carton by packing instructions, guarantee to be printed on every box label batch number, date of manufacture, shelf-life sign.
(10) product inspection
Must be by the laboratory personnel keep sample for the unit random inspection with the batch and make system with product standard and detect and make report final products, and by the Quality Control director according to each process inspection record and survey report overall merit and whether qualifiedly judge, annotate and comment on and whether let pass.Through the quality inspection warehousing after passing.The packing list of packing into.
(11) warehouse-in
Through the quality inspection warehousing after passing.

Claims (8)

1. five resin oral liquid prescriptions with enhancing immunity, slow down aging, looks improving and the skin nourishing effect, it is characterized in that: wine base is a wine; Formula material: PiceameyeriRehd. Et Wils. seed, Sanguis Draxonis, Semen Platycladi, Pollen Pini, Semen Ginkgo, Semen Ginkgo pollen, Flos Camelliae Japonicae powder, Flos Nelumbinis pollen, Radix Ginseng, Ganoderma, Radix Polygoni Multiflori, Poria, Tremella, Mel and attack rare pollen, Flos persicae, Flos Jasmini Sambac.
2. according to the said a kind of five resin oral liquid prescriptions of claim 1, it is characterized in that: be mixed with injection with enhancing immunity, slow down aging, looks improving and the skin nourishing effect.
3. according to the said a kind of five resin oral liquid prescriptions of claim 1, it is characterized in that: be mixed with the external beautifying liquid with enhancing immunity, slow down aging, looks improving and the skin nourishing effect.
4. according to the said a kind of five resin oral liquid prescriptions with enhancing immunity, slow down aging, looks improving and the skin nourishing effect of claim 1, it is characterized in that: wine base is a Chinese liquor.
5. according to the said a kind of five resin oral liquid prescriptions with enhancing immunity, slow down aging, looks improving and the skin nourishing effect of claim 1, it is characterized in that: wine base is a yellow wine.
6. according to the said a kind of five resin oral liquid prescriptions with enhancing immunity, slow down aging, looks improving and the skin nourishing effect of claim 1, it is characterized in that: wine base is a medicated beer.
7. according to the said a kind of five resin oral liquid prescriptions with enhancing immunity, slow down aging, looks improving and the skin nourishing effect of claim 1, it is characterized in that: wine base is a fruit wine.
8. according to the said a kind of five resin oral liquid prescriptions of claim 1, it is characterized in that: be mixed with soft drink with enhancing immunity, slow down aging, looks improving and the skin nourishing effect.
CN2009100935732A 2009-10-13 2009-10-13 Formula of five-tree sap oral liquid having effects of enhancing immunity, delaying senescence, maintaining beauty and keeping young Pending CN102485266A (en)

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CN103082051B (en) * 2013-01-11 2014-06-04 李滋星 Natural plant combined pinocytosis and preparation method thereof
CN103602563A (en) * 2013-10-16 2014-02-26 杨茹芹 Rose red wine fruit juice for beauty treatment
CN106036851A (en) * 2016-06-13 2016-10-26 国药药材健康产业新疆有限公司 Dietary therapy composition for improving endocrine disturbance and caring skin and application of dietary therapy composition in preparation of other food
CN112790376A (en) * 2021-01-18 2021-05-14 浙江安吉芈春蜂业有限公司 Honey and white tea pollen cream and preparation process thereof
CN113397075A (en) * 2021-06-18 2021-09-17 贵州神奇药物研究院 A compound beverage containing extracts of folium Vitis Viniferae and grape skin, and its preparation method

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Application publication date: 20120606