CN106668811A

CN106668811A - Lycium ruthenicum anticancer lifesaving tablets

Info

Publication number: CN106668811A
Application number: CN201611182173.5A
Authority: CN
Inventors: 苟春虎
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-12-20
Filing date: 2016-12-20
Publication date: 2017-05-17

Abstract

The invention provides Lycium ruthenicum anticancer lifesaving tablets, which belongs to high-end health food (food for special medical purpose), and especially employs a Qinghai-Tibet plateau and Qaidam basin natural pollution-free organic green high-quality Lycium ruthenicum extract and other raw materials. The product has the effects for nourishing liver and kidney, nourishing yin and tonifying lung, benefiting qi and nourishing blood, reinforcing spleen and stomach, invigorating blood circulation and reducing phlegm, protecting liver, improving endocrine, supporting right and securing root, promoting digestion, improving appetite, tranquillizing and calming, hypnotizing, resisting anxiety, resisting radiation, resisting fatigue, improving constipation, treating nausea and vomit, resisting virus, resisting microorganisms and inflammation, and preventing and resisting cancer. The product has the effects for enhancing immunization function, inhibiting chemical liver injury, regulating spleen and stomach functions, adjusting neuroendocrine system, improving sleep quality, reducing damages of tissues and organs due to toxic and side effects of radiotherapy and chemotherapy, repairing injured tissues and recovering physical efficiency, improving clinic symptoms of patients, reducing operative complications, preventing recurrence and transfer of tumour, and improving survival quality of patients and delaying lifetime, providing adjuvant therapy for malignant tumor with comprehensive nutrition, supplementing vacuity and assisting cancer postoperative rehabilitation, and the like.

Description

Lycium ruthenicum Murr. anticancer lifesaving piece

First, technical field：The invention belongs to high-end health food (special doctor's food), especially with Qinghai-Tibet Caidamu Basin day Right pollution-free green organic high-quality Lycium ruthenicum Murr. extract, Tricholoma matsutake (lto et lmai) Singer (Grifola frondosa) extract, rue sesame extract, Radix Hedysari extract, sea Ginseng (Radix Codonopsis) extract, Radix Et Caulis Acanthopanacis Senticosi extract, Herba Dendrobii extract, Rhizoma Atractylodis Macrocephalae extract, Semen Ginkgo extract, Bulbus Lilii extract, Rhizoma Curcumae Longae extract, Fructus Amomi Rotunduss (Fructus Amomi) extract, malt extract, Rhizoma Zingiberis Recenss extract, Green tea extract, spirulina extract, Sulforaphen etc. is raw material, is processed using modern state-of-the-art technology and technique.

2nd, background technology：The invention is with Lycium ruthenicum Murr. extract, Tricholoma matsutake (lto et lmai) Singer (Grifola frondosa) extract, rue sesame extract, Radix Hedysari extraction Take thing, Stichopus japonicuss (Radix Codonopsis) extract, Radix Et Caulis Acanthopanacis Senticosi extract, Herba Dendrobii extract, Rhizoma Atractylodis Macrocephalae extract, Semen Ginkgo extract, Bulbus Lilii Extract, Rhizoma Curcumae Longae extract, Fructus Amomi Rotunduss extraction (Fructus Amomi) take thing, malt extract, Rhizoma Zingiberis Recenss extract, Green tea extract, spirulina Extract, sulforaphen etc. are health food made by raw material (special doctor's food).The product nourishing the liver and kidney, YIN nourishing tonifying the lung, QI invigorating are supported Blood, invigorating the spleen and regulating the stomach, phlegm reduction of blood circulation promoting, hepatoprotective, hard masses softening and resolving, improve endocrine, strengthening the body resistance, it is aid digestion, increase appetite, peace Refreshing calmness, hypnosis, anxiety, radioprotective, resisting fatigue, improve constipation, treat Nausea and vomiting, antiviral, anti-inflammation, anti-cancer Anticancer.With immunologic function is strengthened, suppress chemical liver injury, function of spleen and stomach regulating function, adjust neuroendocrine, improve sleep matter Amount, mitigate toxic and side effects of chemoradiotherapy and chemicotherapy to the damage of histoorgan, repair damaged tissues and recover physical ability, improve patient Clinical symptoms, reduction postoperative complication, prevent tumor recurrence and shift, improve life in patients and delay life cycle, synthesis Nutrition adjuvant therapy of malignant tumor, qi-restoratives and cancer postoperative rehabilitation etc. are acted on.Also no this product, innovates research and development in the market The product can be to provide the new product of a kind of auxiliary treatment and rehabilitation to tumor and cancer patient.The product is eaten with pure natural medicine Dual purpose plant is raw material, makes tablet using latest modern technological technology and technique, and purity is high, and biological activity is strong, absorbs, nothing Any toxic and side effects, taking convenience, effect is significant.

3rd, the content of the invention：Love life, scientific prevention and cure cancer.With developing rapidly for China's economy, industrialization, cities and towns Change and lifestyle change and human longevity be expected to extend, aged tendency of population aggravation, cause China's cancer morbidity it is continuous on Rise, cancer has become serious and threatened human life and health number one killer.Quickly being spread of cancer cause the whole society and pay high attention to. Count according to authoritative department, China's new cancer cases 429.2 ten thousand in 2015, dead 281.4 ten thousand, each minute just there are 8 people to be examined Break as cancer, daily newly-increased cancer confirmed cases 1.2 ten thousand, daily death cases of cancer 7500, the life for giving people and essence God brings great pressure, this trend expection that peak will be reached between 2030-2050.Therefore, innovation research and development preventing and treating is swollen Tumor and cancer new product, with far-reaching social meaning.

4th, composition of raw materials：10-60 kilogram of Lycium ruthenicum Murr. extract, 20-70 kilogram of Tricholoma matsutake (lto et lmai) Singer (Grifola frondosa) extract, rue sesame extraction Take 30-80 kilogram of thing, 40-90 kilogram of Radix Hedysari extract, 50-100 kilogram of Stichopus japonicuss (Radix Codonopsis) extract, Radix Et Caulis Acanthopanacis Senticosi extract 15- 50 kilograms, 25-65 kilogram of Herba Dendrobii extract, 35-75 kilogram of Rhizoma Atractylodis Macrocephalae extract, 45-85 kilogram of Semen Ginkgo extract, Bulbus Lilii extraction Take 55-95 kilogram of thing, 10-40 kilogram of Rhizoma Curcumae Longae extract, 20-50 kilogram of Fructus Amomi Rotunduss (Fructus Amomi) extract, Rhizoma Zingiberis Recenss extract 30-60 Kilogram, 40-70 kilogram of Green tea extract, 50-80 kilogram of spirulina extract, 10-40 kilogram of sulforaphen be raw material.

5th, technical scheme：

(1) Lycium ruthenicum Murr. extract：(Lyciam barbarnm extraat), Lycium ruthenicum Murr. are to be grown in Qinghai-Tibet green Ecological environment, pure natural treasure medicine food dual purpose plant Lycium ruthenicum Murr. dry fruit.Lycium ruthenicum Murr. is that a kind of rare precious ecosystem is high End tonic.Lycium ruthenicum Murr. is matrimony vine of solanaceae plant mature fruit.It is mild-natured, sweet in the mouth.Return liver and kidney channel.It is astute with nourishing the liver and kidney, benefit Mesh, effect of lung moistening.For consumption consumptive loss, soreness of waist and knee joint, vertigo and tinnitus, Heat Diabetes, blood deficiency and yellow complexion, raising vision, blurred vision Fail to understand.Modern medicine study thinks that Lycium ruthenicum Murr. has enhancing immunity, resisting fatigue, lowering blood pressure and blood fat, blood sugar lowering, protection The functions such as liver, fat-reducing, defying age, anticancer.

Chemical composition：Lycium ruthenicum Murr. is more containing polysaccharide, aminoacid, glycine betaine, carotene, vitamin B, vitamin C, nicotinic acid etc. Plant the trace element such as vitamin and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalt.And the natural procyanidins also enriched, wherein Procyanidin content is the several times of blue berry content, is to find procyanidin content highest wild plant so far.

Pharmacological action：1st, enhancing immunity：Mouse gavaging water extract or intramuscular injection alcohol extracting thing can significantly increase its net Phagocytic activity of the shape endothelial system to india ink.Water extract or lycium barbarum polysaccharide can promote Turnover of Mouse Peritoneal Macrophages to swallow Lysozyme activity in function and serum.Gavage to normal or Aged Mice or abdomen lycium barbarum polysaccharide, abdominal cavity macrophage can be significantly increased thin Born of the same parents c₃The acceptor number and vigor of b and Fc, can make Aged Mice suppressor T lymphocyte adjust the water that antibody function returns to adult mice It is flat.Lycium ruthenicum Murr. polysaccharide sterling has more significant effect of immune response than crude product, and every immune indexes (include nonspecific immunity Immune organ quality, macrophage phagocytic effect, the serum hemolysin of specific humoral immunity, in specific cellular immunity Move back hair style allergy, lymhocyte transformation rate, E red rose pigments etc.) there is significant difference.

2nd, the liver protecting, anti-fatty liver：Lycium ruthenicum Murr. extract has certain effect to the liver protecting and anti-fatty liver tool.It is existing Find for medical research, contain a kind of effective ingredient-glycine betaine in Lycium ruthenicum Murr., it is very effective to treating hepatic disease.Experiment table Bright, glycine betaine has suppression fat to deposit in hepatocyte, promotes the effect of liver cell regeneration.In addition, the middle glycine betaine of Lycium ruthenicum Murr. Excess fat storage in liver can be prevented, plays the role of anti-fatty liver, it was reported that long-term Jing rats feeding water extract or sweet Dish alkali feedstuff is to ccl₄The hepatic injury for causing has protective effect, can substantially reduce the change of lipid in transaminase and liver, can suppress In liver, lipidosiss and promotion hepatocyte are newborn, and hepatic lipid peroxidation is damaged significant protective effect.

3rd, antioxidation：Lycium ruthenicum Murr. has good antioxidation.Lycium ruthenicum Murr. contains abundant procyanidin, can suppress blood Lipid peroxidation free radical nucleus formation in slurry, can block lipid peroxidation again.In protection DNA, protein and film knot Structure exempts from oxidative damage and plays an important role, it is known that the superoxide dismutase activity in human crystalline lens, cornea and vitreous body It is low, old human plasma and tissue, this is that a kind of support mechanism weakens, it may be possible to old people's plasma lipid peroxide content increase with And one of major reasons of disease such as cataract are susceptible to suffer from, and the procyanidin in Lycium ruthenicum Murr., with powerful antioxidation, can be with Reverse this process.According to another report, the procyanidin in Lycium ruthenicum Murr., due to hydroxyl (phenolic group) portion for having electronics in molecular structure Point, it is the donor by excellent hydrogen or neutron, has very strong oxidation resistance.It is about 50 times of Vitamin E in vivo, is dimension 20 times of raw element C.According to the test report of the French Academy, it is believed that procyanidin is be found most strong, most effective so far One of the clear agent of free radical, especially activity in vivo, is that other antioxidants are incomparable.

4th, anti-stress：Research shows that the spleen weight index of rat is substantially reduced after electric shock plus low dose gamma-ray radiation, brain Cortex index is significantly raised, and spleen and strata cerebrale total lipid content are substantially reduced, and lipid peroxidation product malonaldehyde substantially increases.Abdominal cavity The visible administration group spleen of injection Lycium ruthenicum Murr. extract and the total lipid level of brain homogenate carry nearly matched group, and Splenic vessel MDA contents are significantly reduced, Show that Lycium ruthenicum Murr. extract has anti-stress effect.

5th, radioprotective, leukocyte increasing：Lycium ruthenicum Murr. extract can be obviously promoted the recovery of irradiated mice immunologic function, Mouse thymus index, breeder reaction of splenocyte of raying etc. can be made to be remarkably reinforced.Show that its treatment to radiation sickness has Act on well, it is right⁶⁰Caused by Co irradiations, leukocyte count reduces having obvious leukogenic effect.

6th, to tumor chemoradiotherapy potentiation and Attenuation：Research finds that Lycium ruthenicum Murr. extract is thin to acute weary oxygen tumor Born of the same parents have good radiotherapy potentiation, to body without obvious toxic-side effects.Using the pure mices of C57BL and portable pulmonary carcinoma Model experiment finds that LBP combination with radiotherapeutic shows obvious radiotherapy potentiation；Acute weary oxygen tumor cell is also had necessarily Radiotherapy potentiation, and also have Attenuation to body.

7th, adjust neuroendocrine：Lycium ruthenicum Murr. can substantially increase spleen weight index and Lymphocyte proliferation in common dose Should, and decline spleen norepinephrine (NA) content.The effect is declined by hypothalamuses NA contents, while passing through inferior colliculus Brain-pituitary adrenal axises (HPA) is transferred plasma corticosterone and participates in immunne response and realize.

8th, promote hemopoietic：Lycium ruthenicum Murr. forms can burst forming unit erythroid(BFU E) and erythroid colonies in normal mouse bone marrow Unit rises；Mouse spleen T lymphocytic emiocytosis colony stimulating factors can be promoted, mice serum colony stimulating activity water is improved It is flat；In vivo and in vitro in cultivating system, Lycium ruthenicum Murr. can strengthen the colony stimulating activity of colony stimulating factor.In addition, Lycium ruthenicum Murr. may be used also Normal mouse marrow hemopoietic stem cells are promoted to break up to particle, with the function of promoting bone marrow hematogenesis.

9th, mutation：Lycium ruthenicum Murr. has anti-mitogen mould (MMC) induction sister chromosome, and monomer interchange reaction can improve DNA damages Repair ability after wound, reduces sister chromatid frequency, resists genetic damage.Lycium ruthenicum Murr. can also promote the normal of lymphocyte Proliferating cycle and the proliferation activity of the mould impact of mitogen.Show Lycium ruthenicum Murr. to safeguarding cell normal development, improve DNA repair abilities and The rejuvenation direction reverse of senile cell is promoted to have certain effect.Recent study shows that Lycium ruthenicum Murr. has anti-gene mutation Effect, with the generation of preventing tumor.

10th, anticancer antitumor：Research shows that Lycium ruthenicum Murr. has good antitumor action, can promote death of neoplastic cells. Lycium ruthenicum Murr. extract can prevent and reduce cells in vivo canceration, can ensure the normal of human body sexual cell and embryonic cell again Growth, reduces the growth of genetic diseasess malformation；Cancer development is can control, is suppressed tumour growth, and tumour radiotherapy is controlled Treatment has obvious potentiation and protective effect；Can also improve and protect the immunologic function of radiation patient.Can also potentiation with chemotherapy combination Attenuation.Separately there is research, Lycium ruthenicum Murr. contains abundant procyanidin, can occur by the activity suppression canceration of relevant enzyme.Grind Study carefully discovery, procyanidin has significant anticancer function, suppressing metastasis effect in the growth cycle of cancerous cell, induction is withered Die, Inhibit proliferaton.Procyanidin can also pass through to cut off the blood supply needed for cancerous cell in addition, prevent cancerous cell diffusion.According to state Interior report, Lycium ruthenicum Murr. contain abundant procyanidin, have preventive and therapeutic effect to breast carcinoma.Breast can be reduced in anthocyanidin with Lycium ruthenicum Murr. Adenocarcinoma nude mice and the rate of transform of lymph, reduce nude mouse xenograft tumor angiogenesis and expression, so as to suppress tumor-blood-vessel growth, Promote tumor death, with significant antitumor efficacy.

(2), Tricholoma matsutake (lto et lmai) Singer extract (Tricholoma matsutake extract), also known as armillaria Matsutake etc., is smooth daughter bacteria, mouth The sporophore of mushroom section plant pine oak, warm in nature, sweet in the mouth, returns kidney, stomach.With kidney invigorating and YANG supporting, salubrity, beneficial stomach, activating QI to eliminate phlegm, drive The effects such as worm.For the disease such as soreness of the waist and knees, Light-headedness, the coughing of damp-phlegm, nausea and vomiting, limbs are sleepy.Research now shows, loose Fine and soft enhancing immunity, treatment diabetes and treatment cardiovascular disease, the liver protecting, looks improving and the skin nourishing, promotion gastrointestinal function, anti-spoke Penetrate, the effect such as mutation, cancer-resisting.

Chemical composition：Tricholoma matsutake (lto et lmai) Singer is containing blazei polysaccharide, Tricholoma matsutake (lto et lmai) Singer polypeptide, matsutakealcohol, 18 kinds of aminoacid, unsaturated fatty acid, sugared eggs In vain, various active enzyme, abundant dietary fiber, multivitamin and various trace elements and bioactive substance, are referred to as day Right nutrition treasure-house.

Pharmacological action：1st, anticancer antitumor：Research shows that Tricholoma matsutake (lto et lmai) Singer has good anticancer and antitumor action.Tricholoma matsutake (lto et lmai) Singer contains There is the special double-strand bioactive substance " matsutakealcohol (RNA) " that a kind of other any plants all do not have, it has superpower anti-gene Mutation ability and strong antitumaous effect, anti-gene mutation ability and strong antitumaous effect secreted by energy automatic identification tumor cell, can be certainly Toxin secreted by dynamic tumor cell, targeting are close to tumor cell, combine, by dissolving tumor cell membrane and broken Bad double-layer of lipoid enters intracellular, closes the swivel protein receptor of tumor cell, blocks the protein synthesis of tumor cell, makes to swell Oncocyte is unable to schizogamy so that dead, destroys the DNA genes of tumor cell genetic copying, so as to reach anti-gene mutation, Suppress the purpose of tumour growth and control tumor recurrence and transfer.Further research shows that the polysaccharide antitumor contained by Tricholoma matsutake (lto et lmai) Singer is lived Property much cancers be higher than Ganoderma, belong to the first during there is anti-tumor activity edible fungi at 15 kinds.Its fruiting body extract (polysaccharide) 91.8% is up to the suppression ratio of S180 sarcoma, is 70% to the suppression ratio of the film water cancer that ends, separately be there are some researches show, Tricholoma matsutake (lto et lmai) Singer sugar Albumen MTSO also has inhibitory action to human breast cancer cell, at the same blazei polysaccharide can also inducing cell apoptosis, suppress leukocyte Propagation；Research is it is also shown that liver cancer patient is taken Tricholoma matsutake (lto et lmai) Singer after hepatectomy and can significantly improve survival rate.Its mechanism of action one is straight Connect kill tumor cell.Two is inducing apoptosis of tumour cell.Tricholoma matsutake (lto et lmai) Singer is alternatively arranged as cancer postoperative adjuvant therapy and postoperative health in addition Multiple medicine.

2nd, promote gastrointestinal function：Experiment shows that Tricholoma matsutake (lto et lmai) Singer extracting solution can strengthen normal mouse gastrointestinal peristalsiss, has similar gastrointestinal The effect of medicine is actuated, mice can be suppressed again to have loose bowels because gastrointestinal function that neostigmine load causes is hyperfunction and insufficiency of the spleen caused, made Mice with spleen deficiency body weight substantially increases, and sign is significantly improved, therefore, Tricholoma matsutake (lto et lmai) Singer has good promotion gastrointestinal function.

3rd, mutation and radioprotective：Research shows that Tricholoma matsutake (lto et lmai) Singer extracting solution can strengthen mutation ability, especially is preventing from receiving Radiation and the cell carcinogenesis effect is significant of chemical contamination.Research confirms that Tricholoma matsutake (lto et lmai) Singer can repair human immune system, improves human immunity Power is reaching mutation and radiation resistance.Separately there is research, blazei polysaccharide can remove human free radical and peroxide, and protection is thin Born of the same parents will not be mutated, while protecting cell not by by injuring for radiating.

4th, antiviral：There is blazei polysaccharide obvious influenza to emit the effect of viral and little herpes simplex virus type, And with the effect of virus induction interferon is promoted, thus speculate that its antiviral effect and enhance immunity are had with blazei polysaccharide Close.

5th, it is anti-ageing：Tricholoma matsutake (lto et lmai) Singer energy enhancing body oxidation resistance, removes human body and produces excessive free radical, reduce histiocyte Extent of peroxidation, improve body immunity, with anti-aging effects.

In addition, Tricholoma matsutake (lto et lmai) Singer also has the effect for the treatment of cardiovascular disease and treatment diabetes and beauty.

6th, treat cardiovascular disease：Tricholoma matsutake (lto et lmai) Singer has the effect for the treatment of cardiovascular diseasess.Research shows, containing abundant in Tricholoma matsutake (lto et lmai) Singer The compositions such as unsaturated fatty acid, can effectively eliminate the rubbish in blood of human body, reduce blood viscosity and cholesterol and glycerol three Ester, prevents and treats hypertension, hyperlipidemia, arteriosclerosis and cardio-cerebrovascular diseases.

7th, the liver protecting：Tricholoma matsutake (lto et lmai) Singer has very strong free radical scavenging effect, can suppress and block free radical and cause lipid mistake Oxidation reaction, enhancing superoxide dismutase, CAT, GSH-P are active, improve antioxidant ability of organism, the work with hepatoprotective With.

8th, enhancing immunity：Tricholoma matsutake (lto et lmai) Singer contains the various nutritional labelings of tens kinds of needed by human body, closes enhancing immunity with protecting Effect, the double-strand blazei polysaccharide being particularly rich in Tricholoma matsutake (lto et lmai) Singer, can human activin T cell, to nonspecific immunity and special Property immunity have significant potentiation, there is significant effect to physical weakness, the quick enhance immunity of postoperative crowd in puerperal.

In addition, Tricholoma matsutake (lto et lmai) Singer also have looks improving and the skin nourishing, defying age, treat diabetes, improve gastrointestinal function, radioprotective, mutation, The effects such as cancer-resisting.

(3), Radix Hedysari extract (Radix Hedysari extract), is the dry root of many sequence rock Radix Hedysari of leguminous plant, Warm in nature, sweet in the mouth, return lung, spleen channel have tonifying Qi and lifting yang, and tonifying the lung is moisturized, strengthening superficial resistance to stop perspiration, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema, expelling pus and promoting granulation etc. Effect.For treatment deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, deficiency of vital energy edema, blood deficiency and yellow complexion, Heat Diabetes, rush down prolapse of the anus for a long time, QI invigorating Consolidating superficial resistance, uterine bleeding of having blood in stool, deficiency of the lung shortness of breath arrange dense granulation promoting, and skin infection is difficult the function such as to burst.Modern medicine study shows that Radix Hedysari has righting Consolidate, strengthen immunologic function, anticancer antitumor, the liver protecting, radioprotective, resisting fatigue, the anemia that improves, anoxia enduring, relieving constipation, drop blood Pressure, blood fat reducing, blood sugar lowering, lose weight, improve the health care of sleep, improve memory, slow down aging, protect gastric mucosa, dispel yellowish-brown class, dispel Cuo Skin ulcer, improve moisture of skin, promotion and ooze breast, increase bone density etc..Radix Hedysari is also with treatment oedema due to nephritis, heart failure, egg in recent years Albiduria, peptic ulcer, chronic hepatitiss prevent weak, the disease such as respiratory tract infection.

Chemical composition：It is Radix Hedysari glycosides containing Radix Hedysari, different acyl Radix Hedysari glycosides, different Radix Hedysari saponin, kaempferol, Quercetin, Hedysamn polysaccharide, hard Fat number, ferulic acid, β-paddy flute alcohol, choline and several amino acids etc..

Pharmacological action：1st, strengthen immunologic function：Research shows that red formula water decoction can promote gulping down for Turnover of Mouse Peritoneal Macrophages Function is bitten, Hedysamn polysaccharide has facilitation to Turnover of Mouse Peritoneal Macrophages phagocytosis and has rush to body non-specific immunity Enter and adjustment effect.Hedysamn polysaccharide can substantially increase mouse spleen, thymic weight, to spleen, thymic weight caused by meticortelone Mitigation has obvious antagonism.T cell quantity in mouse thymus and spleen can also be made substantially to increase, promote the generation of antibody, Strengthen human lymphocyte, the activation of the neutrophil cell of peritoneal macrophage.Complement Jing after cobratoxin process is declined, The Cavia porcelluss that phagocytic rate declines have promotion complement reparation, and the function of promoting neutrophilic leukocyte phagocytic rate to improve and recover improves mice The level of lymphocyte IL-2 and IL-2R, makes the T lymphocytes and the conversion capability of bone-marrow-derived lymphocyte of After Scalding In Rat spleen, antibody Forming cell quantity substantially increases.In addition, Radix Hedysari extract can also improve macrophage, T lymphocytes and bone-marrow-derived lymphocyte are adjusted Energy-conservation power, Radix Hedysari injection liquid energy make anemia mice ex vivo adipocytes secreting tumor necrosis factor (TNF) significantly raised etc..

2nd, suppress tumor：Research finds that Radix Hedysari prevents gene mutation, and free radical is to cause gene mutation to lead The one of the main reasons of carcinogenic disease.Research thinks that the flavone compound that Radix Hedysari contains has the effect for removing free radical, can break The metabolism environment of bad tumor, the metabolic rate for reducing tumor and the speed of growth for suppressing tumor cell.Further study, Radix Hedysari contains There is abundant active polysaccharide energy immune stimulating activity, strengthen the effect of reticuloendothelial system phagocytic tumor cell, promote lymph thin Dysuria with lower abdominal colic, activation T cell and B cell, and promote the formation of antibody, so as to have the effect for suppressing tumor.In addition, have been reported that, Radix Hedysari water extract is to the suppression ratio of gastric carcinoma cells AGS up to 94.94%.

3rd, antiviral：Experiment in vitro shows that Radix Hedysari has the effect for significantly suppressing virus and protection virus infected cell； Experiment in vivo proves that Hedysarum polybotrys extend the time-to-live to virus infected mice with death is slowed down, and protection mice must not the heart The effect of myositis or mitigation myocarditiss pathological changes, points out Hedysarum polybotrys to play very important effect in control virus infection.

4th, promote hemopoietic：Radix Hedysari lumbar injection can increase normal mouse grain system hemopoietic function, make the single grain system group of bone marrow thin Born of the same parents' number is apparently higher than matched group；Extremely there is significant protective effect to caused by cyclophosphamide hemopoietic function of bone marrow, bone marrow can be prevented Number of nucleated cells is significantly reduced.Radix Hedysari extract gavages mice and can improve posthemorrhagic anemia mice RBC number, reticulocyte Number, increases hemolytic mouse red blood cell number, and Hemoglobin Value, packed cell volume value resist cyclophosphamide, X-ray induced mice Cell number and bonemarrow nucleated cells number decline, with promote hemopoietic system function effect.

5th, antiinflammatory：Radix Hedysari has significant inhibitory action to rat paw edema caused by 5-hydroxy tryptamine.To mice dimethylbenzene institute Ear corridor inflammation and rat granuloma hypertrophy is caused to have significant inhibitory action.Rat injection Radix Hedysari water extract substantially can suppress Capillary permeability caused by 5-HT and histamine phosphate increases.

6th, the liver protecting：Radix Hedysari water decoction and Hedysamn polysaccharide and Radix Hedysari saponin are to chmice acute CCl4 toxics hepatitis, interior Toxin poisoning is damaged, galactose, and the hepatic injury such as acetic acid phenol is respectively provided with pathological changes and the death for mitigating that liver poisoning causes, this and Radix Hedysari Antibiooxidation is relevant with the close ability of metabolism is adjusted.After mouse gavaging, histochemical method checks that the visible glycogen of liver increases, Lysosome and tissue dehydrogenase are enlivened.During the obvious anti-endotoxin of Hedysamn polysaccharide energy processes mouse liver even slurry, malonaldehyde is raised and is gone back Prototype glutathion is reduced, and Electronic Speculum shows, induced by endotoxin processes the damage of mouse liver structure of mitochondria protective effect.

7th, radioprotective：Hedysamn polysaccharide can promote the spleen tissue structure that the mice after lonizing radiation irradiation damages substantially to recover, Improve the ultrastructure of spleen endolymph cell, improve the activity of succinum number dehydrogenase in peripheral blood lymphocyte.And to 60CO Mouse Weight caused by irradiation declines, and number of white blood cells declines the Ultrastructural change of regulating liver-QI significant protective effect.

8th, protect kidney：The intravenous injection of Radix Hedysari injection can be such that the serum albumin of rat minimal change nephropathy model substantially rises Height, and the blood fortune of glomerular capillary silk can be increased, to rabbit system mould productive nephritises, can obviously reduce glomerule Xi Mo areas IgG and C₃Deposition.Radix Hedysari can substantially reduce the amount of albumen in urine, mitigate nephropathy degree.The Radix Hedysari treatment nephrotic syndrome Mechanism is the protein synthesis for promoting to suffer from body, improves seralbumin concentration, so as to improve its clinical manifestation.

9th, anti-pulmonary hypertension：Radix Hedysari has to tremulous pulse configuration restructuring in hypoxic pulmonary hypertension in rats and low pressure gonad bubble Significantly resistance inhibitor action, shows as protecting lung pulmonary arterial wall cell in acinus, suppresses vascular smooth muscle cell curing, loose and thin Extracellular matrix increases, and reduces increasing for blood vessel wall external mold fibroblast and collagen fiber, expands the lung shunk because of anoxia thin Petty action vessel lumen etc..

10th, resisting fatigue：Hedysamn polysaccharide lumbar injection, can significantly extend normal mouse and oxidation cortisone causes " deficiency of YIN " mice Room temperature swimming time, and increase mice adrenal gland weight under stress state.

11st, anti-hypoxia：Radix hedysari oral liquid gavage, it is little that Hedysamn polysaccharide lumbar injection is processed to normal and isoproterenol Cerebral anoxia caused by Mus normal pressure and hypobaric hypoxia, cyanide poisoning anoxia and ligation bilateral carotid has significant antagonism Effect, can be obviously prolonged the mouse survival time.

12nd, cold-resistant：Hedysamn polysaccharide lumbar injection can bright enhancing normal mouse, hungry mice and hydrocortisone process mice Low temperature resistant (- 5 DEG C) ability so as to life span is obviously prolonged.

13rd, it is calm：Mouse subcutaneous injection Radix Hedysari can maintain a few hours sedation.Radix Hedysari water decoction is continuously drunk to mice 15 days, the exploratory behavior activity of mice wilderness and spontaneous activity, and energy antagonism pentobarbital sodium can be suppressed, extend sleeping for chloral hydrate The dormancy time.

14th, ease pain：Mouse writhing method and hot plate method experiment show that Radix Hedysari saponin first and sheep Radix Hedysari glycosides have significantly analgesia Make and.

15th, antibacterial：Radix Hedysari in vitro to Hayes shigella dysenteriae, anthrax bacillus, Alpha-hemolytic streptococcus, Beta-hemolytic streptococcus, Diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureuses, white grapes bacterium have obvious antibacterial action.

16th, hormone-like effect：Radix Hedysari extractum, Radix Hedysari lactone and Radix Hedysari sterin are to rat, the body weight of mice, levator ani or kidney The weight such as dirty has a significant effect, and shows without anabolic hormone and Andrin-like action.Radix Hedysari can be such that mice substantially prolongs rutting period It is continuous 10 days as long as, there is estrogenic promoting action.Radix Hedysari extract can suppress the bone resorption of ovariectomized female rats, with osteoporosis Effect.

17th, expansion of blood vessels：Radix Hedysari has the effect of expansion of coronary artery and whole body peripheral vessel, can improve blood and follow Ring and nutriture, can make cell growth vigorous, promote organism metabolism.

18th, defying age：Hedysamn polysaccharide has significantly rising to the content of superoxide dismutase in old rats erythrocyte Act on, and this rising is acted on as the increase of dosage becomes apparent from.Hedysamn polysaccharide can increase adult mice liver,kidney,spleen and the heart Dirty rna content, promotes protein synthesis, increases cell function, slow down aging process.Prompting Radix Hedysari has certain Anti-aging effects.

19th, improve the health care of sleep：Radix Hedysari saponin work and water decoction gavage or abdomen note, freely activity is reduced to make mice, extends bar Than the appropriate length of one's sleep, fistfight is reduced.

20th, the effect to cardiovascular system：The polysaccharide extracted from Radix Hedysari and saponin, it is Jing physiology, biochemical, morphologic 17 indexs unanimously show, the heart of dog with acute myocardial infarction is had improves myocardial contraction, and reducing myocardial infarction area mitigates the heart Muscle injury etc. is acted on.In addition, Hedysamn polysaccharide is also significantly reduced myocardial contraction, mitigate the rich effect of the morning of sinus rate, And the reduction of rabbit ventricular pressure, cardiac output reduction, reduce myocardial oxygen consumption and protection ischemic myocardium can be further resulted in, to hypophysis The Acute Myocardial Ischemia in Rats that pituitrin causes has significant protective effect, can substantially resist BaCl₂The rat heart rate of induction loses Normal and CHCL₃The mice room of induction is quivered, and improves platelet adhesion reaction rate, reduces the effect such as heart rate.

In addition, Radix Hedysari also have antioxidation, lowering blood pressure and blood fat, blood sugar lowering, improve constipation fat-reducing, protection gastric mucosa, U.S. Hold skin care, improve memory, increase the effect such as bone density.

(4), rue sesame extract (Yun Zhi Extract), is that many Cordycepps plant rue sesames are dried sporophore.It is mild-natured, taste It is sweet, GUIXIN, lung, liver and kidney channel.There is the effects such as invigorating QI and tranquilization, relieving cough and asthma, invigorating spleen and reinforcing stomach, beneficial vital essence, bone and muscle strengthening.For cardiopalmus The diseases such as shortness of breath, dizziness sleeplessness, asthenia cough with asthma, dyspepsia, hepatitis.Modern pharmacological research shows, with enhancing immunity, anti-tired Labor, the liver protecting, improve the health care of sleep, mutation, radioprotective, calmness, ease pain, relieving asthma, antiallergic, heart tonifying, arrhythmia, cough-relieving Relieving asthma, lowering blood pressure and blood fat, blood sugar lowering, defying age, the anti-cancer effect such as auxiliary for treating cancer.

Chemical composition：Rue sesame containing coriolan, nucleoside, various enzymes, triterpene, ergosterol organic acid, glucosamine, half 13 kinds of aminoacid such as Lactose, xylose, mannose, maltose, alkaloid, choline, glycine betaine, arginine, tryptophan, water solublity egg In vain, volatile oil, several mineral materials and inorganic elementss etc..

Pharmacological action：1st, strengthen immunologic function：(1) strengthen cellular immune function, rue sesame extract can increase T lymphocytes Number, strengthens the delayed hypersensitivity reaction of induction, hence it is evident that strengthen the function of cytotoxic T cell, and when its concentration is high, killing activity increases 100%, strengthen the effect of K cells and NK cytoactives in animal subject body, strengthen the phagocytic activity of macrophage.(2) strengthen Humoral immune function, B cell can be produced the plasma cell of various immunoglobulins by differentiation and proliferation after antigenic stimulus, improve body fluid Immunity.(3) promote lymphocyte factor, activate NK cells.(4) mouse spleen lymphocyte DNA synthesis and DNA polymerases are strengthened Vigor.

2nd, anticancer, auxiliary for treating cancer：Rue sesame ethanol extraction can strengthen the spleen natural killer cell (NK) of mice Activity, has significant inhibitory action to cancer.Rue sesame crude extract to mice S180 suppression ratio up to 84.6%, and to pulmonary turn Moving focus also has inhibitory action.Also research shows, coriolan is used alone that can to significantly inhibit human colon carcinoma thin in vitro Born of the same parents breed and induce apoptosis of human hepatoma cell.Its mechanism of action is realized by strengthening immunologic function.In recent years, Chinese medicine into Divide and suppress the research of tumor-blood-vessel growth more, research is thought to suppress angiogenesis to be one of Chinese medicine antitumor main mechanism, swells Tumor recurs the important promotive factor with transfer as angiogenesis, closely related with growth and metastasis of tumours, and coriolan It is inhibited to tumor-blood-vessel growth.Animal blood vessels generation model carries out research confirmation, and coriolan is to antitumor action Suppress angiogenesis and cell adhesion with which, have research coriolan combination with cisplatin to be observed to cancer angiogenesis result table Bright, two medicines joint can effectively suppress the formation of new vesselses in swollen tissue.Therefore, use in conjunction can play preferable antitumor effect Really, can become.

3rd, mutation：The Mouse Bone cell micronucleus incidence rate that rue sesame aqueous extract is induced to cyclophosphamide has significantly suppression Effect, compared with matched group, difference has significance；Gene mutation to the hamster V79 cells of mitomycin induction has suppression to make With, compared with matched group, the difference of middle and high dosage group has significance.Test confirms that rue sesame aqueous extract has certain resisting Mutation effect.

4th, it is calm：There is rapidly sedation in mouse peritoneal injection rue sesame fermentation liquid energy, shows as spontaneous activity and substantially subtracts Few, muscular tension declines, and sedation increases with dosage and strengthens, and mouse peritoneal injection rue sesame extracting solution can significantly extend ring Ortal Sodium length of one's sleep, strengthen chlorpromazine, the sedation of Reserpine, the excitation of antagonism amfetamine.

5th, ease pain：Hot plate method experiment shows that rue sesame intraperitoneal administration has analgesic effect.Electrostimulation and hot plate method experiment table Bright, rue sesame can improve the mice threshold of pain.

6th, eliminating phlegm and stopping cough：Constant pressure ammonium hydroxide spraying draw cough method experiment show, rue sesame aqueous extract, ethanol extract have Antitussive action.The phenol red method of mice is tested and is shown, rue sesame aqueous extract, and ethanol extract, hot alcohol extraction liquid have disease of significantly dispelling Effect.Therefore, rue sesame has functions that obvious cough-relieving is dispelled disease.

7th, relieving asthma：The isolated tracheal smooth muscle that rue sesame liquid and concentrated broth cause to histamine shrinks effect of alleviating pain, And action intensity is directly proportional to drug level used.

8th, heart tonifying：Rue sesame has obvious cardiotonic.Rue sesame tincture has significantly strong to normal Ba Mushi Isolated Toad Hearts The heart is acted on.In certain scope, cardiotonic increases with dosage and strengthens.Lumbar injection rue sesame is to having substantially strong in body Cor Leporis The heart is acted on.

9th, resist myocardial ischemia：The acute myocardial ischemia that rue sesame liquid causes to pituitrin to Normal Conscious rabbit intravenous There is certain protective effect, the T ripples that electrograph can be made towering are significantly reduced.Rue sesame can also strengthen cardiac muscle nutritional blood flow, improve Myocardial Microcirculation, increases myocardial oxygen and gives, have good protective effect to myocardial ischemia.

10th, the liver protecting：Mice lavage rue sesame can mitigate the pathological lesion that carbon tetrachloride causes, and mitigate carbon tetrachloride Infringement to liver detoxification function, the glutamate pyruvate transaminase that rue sesame wine extraction thing causes to carbon tetrachloride-injured hepatocytes is raised bright Aobvious reduction effect, can make Mouse Liver homogenate Cytochrome P450 content than matched group phase to mouse peritoneal injection coriolan Than, it was demonstrated that rue sesame can adjust the content and activity of activity in vivo material, improve the detoxification ability of liver, have the liver protecting to act on.

11st, promote the synthesis of protein and nucleic acid：Mouse peritoneal injection coriolan, can make H- leucines, H- thymus phonetic Pyridine nucleoside and H- uridines mix medullary cell protein respectively, and as a result the incorporation of DNA, RNA is than the obvious increasing of matched group Plus, it was demonstrated that coriolan can promote medullary cell protein, the synthesis of nucleic acid, and accelerate the division growth of medullary cell.

12nd, anti-radiation：Rue sesame has certain anti-radiation effect,⁶⁰Before Co roentgenizations, gavage gives rue sesame liquid, irradiation Continue administration 2 weeks afterwards, animal dead can be significantly reduced.Rue sesame extract lumbar injection is damaged and is had to mice Jing roentgen radiation xs Certain protective effect, the recovery of Mouse Weight and hemogram after promoting to irradiate.Rue sesame to the protective effect of radiation injury with Its excited bone marrow hematogenesis function is relevant.

13rd, remove free radical：Rue sesame can substantially remove human body oxygen-derived free radicals, and be in dose-effect relationship, have removing super oxygen in vitro The ability of anion and hydroxy radical.Rue sesame water extract has the effect for significantly removing superoxide radical.

(5), Stichopus japonicuss (Sea eueumber), is the entirety of Stichopodidae animal Stichopus japonicuss.It is warm in nature, sweet in the mouth, salty.With the kidney invigorating Spermatogenesis, blood enriching and dryness moistening, the effect for nourishing the five internal organs.Cure mainly the general power of deficiency of the kidney, impotence and seminal emission, frequency of micturition, the soreness of waist, cloudy anemia Damage, emaciated physique, hectic fever are coughed, spit blood, quenching one's thirst, constipation etc..Modern medicine research shows, enhancing immunity, looks improving and the skin nourishing, anti- Fatigue, enhancing development, slow down aging, lowering blood pressure and blood fat, prevent and treat anemia, diabetes, postoperative health recovery, anticancer etc. Effect.

Chemical composition：Mucopolysaccharide containing Stichopus japonicuss, collagen protein, selenka, holothurin, glucosamine, it is protein, various The composition such as vitamin and trace element.

Pharmacological action：1st, flaccidity is treated in the kidney invigorating：Research shows that Stichopus japonicuss have good the kidney invigorating, tonifying YANG, the effect for treating flaccidity.Ancient medical book 《Say age》Say：" Stichopus japonicuss likeness in form man's sun, can be with the kidney invigorating Xing Yang ",《Bencao Congxin》Add Stichopus japonicuss " Gan Xianwen, the kidney invigorating and essence nourishing, tonifying YANG Treat flaccidity ", and《Diet spectrum is occupied with breath》Stichopus japonicuss " nourishing YIN and supplementing blood, strong sun are moisturized ".Think from Chinese medicine " cause sexual impotence, the one of premature ejaculation Individual critically important the reason for is that, due to Liver and kidney YIN-fluid being insufficient, kidney yang declines what is caused, and it is which that the effect of flaccidity is controlled in Stichopus japonicuss tonifying YANG " liver and kidney tonifying Cloudy, effect of invigorating kidney-YANG.Stichopus japonicuss contain according to another report zinc, acidic polysaccharose, holothurin isoreactivity composition, erect with improving The effect of function.

2nd, enhancing immunity：Stichopus japonicuss mucopolysaccharide lumbar injection is to normal mouse, lotus knurl (MA-73) mice and cyclophosphamide The mice of the immunocompromised for causing can make its Cellular immunity suppression recovering state, phagocytic function and delayed hypersensitive reaction (DHR) Improve.The weight of immune organ spleen, thymus can be strengthened to Mouse oral holothurian oral liquid preparation, and mouse red blood cell can be improved and be surpassed The activity of superoxide dismutase (SOD).

3rd, resisting fatigue, anoxia enduring：Stichopus japonicuss decoct can significantly improve the heat-resisting ability of mice to mouse stomach, increase mice Swimming time, improve mice sealing anaerobic condition under time-to-live.

4th, qi-restoratives, postoperative rehabilitation effect：Stichopus japonicuss have strengthening the body resistance, improve the effect of immunologic function, build up resistance, disease People consumes substantial amounts of nutrient substance during sick, operation, and now body requirement supplements the nutritional labeling of various urgent needs.And Stichopus japonicuss Containing nutritional labelings such as abundant arginine, arginine is the important source material of synthesized human collagen protein, after body injury Reparation has specially good effect.Have it is demonstrated experimentally that eat appropriate Stichopus japonicuss daily, patient can be made to shift to an earlier date comprehensive rehabilitation in 20 days or so, therefore, handss Postoperative patient, puerpera, fracture traumatic patient beche-de-mer can stop blooding, enrich blood, rebuild one's physical constitution, and can substantially shorten rehabilitation duration.

5th, defying age：Holothurian oral liquid can be obviously prolonged the life-span of fruit bat, with anti-aging effects.Additionally, Stichopus japonicuss also have There are the effects such as anticoagulant, antiviral, radioprotective, analgesia, antifungal, antitumor, reduction cholesterol, antioxidation, looks improving and the skin nourishing.

6th, radioprotective：Can significantly improve to mouse peritoneal injection Stichopus japonicuss acidic mucopolysaccharide and be survived by lonizing radiation irradiation mice Rate, can be such that acute radiation injury mouse bone marrow cells Other nucleated cells differential count significantly improves compared with matched group, and spleen weight increases, endogenouss collection Fall, illustrate that Stichopus japonicuss acidic mucopolysaccharide has preventing and treating acute radiation injury and promotes the effect of hematopoietic function recovery.

7th, antiviral：Stichopus japonicuss have obvious antivirus action to herpes simplex virus etc..

8th, ease pain：The writhing response that sea cucumber extract can cause to mouse peritoneal injection acetic acid, 20% sea cucumber extract Analgesic activities of the 1ml equivalent to 1mg morphines.

9th, antibacterial：Stichopus japonicuss have obvious inhibitory action to funguses such as Candida albicans.Selenka is to candida albicans, warm Also there is very strong inhibitory action with candida mycoderma, candida krusei.

10th, enrich blood：Stichopus japonicuss blood tonification effect is closely related with medulla hematopoietic system.It is demonstrated experimentally that Stichopus japonicuss are made to mice multipotency Hemocytoblast has certain proliferation and differentiation effect, and inside and outside source property Spleen nodes number can be made to be significantly increased compared with matched group, and Stichopus japonicuss are mended Blood effect is relevant with hematopoietic stem cell.

11st, suppress growth of tumour cell：Growth of the Stichopus japonicuss mucopolysaccharide lumbar injection to mice H22 transplanted tumoies, lymphosarcoma, Mouse breast cancer has inhibitory action, and the natural transfer to pulmonary carcinoma has significant antagonism.Show that Stichopus japonicuss mucopolysaccharide makes to pass through The expression of the related gene of cell propagation is adjusted, is made tumour cell cycle that retardance to occur, is suppressed growth of tumour cell to reach Effect.Separately there is research, Stichopus japonicuss proteoglycan also has the effect of mutation and protection DNA.

(6), Radix Et Caulis Acanthopanacis Senticosi extract (Thorn extract), is that Araliaceae Radix Et Caulis Acanthopanacis Senticosi is dried root and rhizome.Property Temperature, hides flat, slight bitter.Returns spleen, purport, heart channel.There are replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, bone and muscle strengthening effect.It is weary for deficiency of spleen-YANG and kidneyYANG, body void Power, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep, muscles and bones impotence, rheumatic arthralgia etc..

Chemical composition：Containing glucosides, eleutheroside A, B, C, D, E, F, G；Polysaccharide, flavonoid, neociwujiaphenol, resin, Vitaminss, tannin, Palmic acid, linolenic acid, Oleic acid etc..

Pharmacological action：1st, resisting fatigue, Radix Et Caulis Acanthopanacis Senticosi are tested to rat Loaned swimming test and mice rope climbing method and are shown, Radix Et Caulis Acanthopanacis Senticosi Extract and glycoside material have obvious antifatigue effect, and its effect is stronger than Radix Ginseng.

2nd, strengthen immunologic function：Radix Et Caulis Acanthopanacis Senticosi polysaccharide and methods of glycosides can significantly improve cell and produce the energy for inducing dry anti-element Power, Radix Et Caulis Acanthopanacis Senticosi can strengthen the phagocytic activity of the phagocytic activity and peritoneal macrophage of netted endoplasm system, improve rosette Percentage rate；Polysaccharide component can substantially increase the activity that CTL kills target cell, promote concanavalin A to stimulate mouse boosting cell secretion white Cytokine.

3rd, antibacterial, antiviral：Radix Et Caulis Acanthopanacis Senticosi has certain bacteriostasis to Staphylococcus albus, escherichia coli etc.：Polysaccharide into Dividing strengthens the ability of guinea pig anti-human type tulase.In addition, Radix Et Caulis Acanthopanacis Senticosi also has inhibitory action to encephalitis virus infection.But also have been reported that Radix Et Caulis Acanthopanacis Senticosi extract is improved the ability of Bacterium entericum.

4th, antiinflammatory：Radix Et Caulis Acanthopanacis Senticosi can mitigate hot inflammatory edema to the mice of adrenalectomize, can prevent formaldehyde joint The development of inflammation, mitigates the inflammation that normal saline and protein solution cause.

5th, resist myocardial ischemia：Radix Et Caulis Acanthopanacis Senticosi extract energy expansion of blood vessels, improves blood supply in brain amount.Its rhizome D- door spoon extracts There is very strong inhibitory action to platelet aggregation, and have antiarrhythmic to act on, the damage of Rabbit Myocardium ischemia group can be mitigated, promoted The regeneration and infarct zone for entering superficial cell recovers.

6th, defying age：Research shows that it is firm that there is Radix Et Caulis Acanthopanacis Senticosi obvious defying age to make.Oral Administration in Rats Radix Et Caulis Acanthopanacis Senticosi is after 2 months, red Cytolipin oxide content is reduced, and enzymatic activity is raised.Radix Et Caulis Acanthopanacis Senticosi ethanol extraction can extend mice ligation bilateral common carotid arteries Or the time-to-live that broken end is panted：And the rat moon can be reduced：The level of lipid peroxide in FA halogen, improves superoxides in blood plasma The activity of dismutase (SOD), has protective effect to postischemic reperfusion intracerebral lipid peroxidation content increase.

7th, anti-stress：Radix Et Caulis Acanthopanacis Senticosi aqueous extract and alcohol medicinal extract can increase mice to high temperature and the tolerance of low temperature, it is possible to decrease high Temperature or Cold stress stimulate and cause dead mouse.

8th, radioprotective：Radix Et Caulis Acanthopanacis Senticosi can strengthen the radiation-resistant ability of animal, extend the life span of raying rat, to red thin Born of the same parents have protective effect when being subjected to radiation sample material leaching evil.Cyto-architectural recovery to hemopoietic system radiation injury in mice has rush Enter effect.

9th, antitumor：Transplanted tumor of the Radix Et Caulis Acanthopanacis Senticosi extract to zoopery, drug-induced tumor have certain suppression Effect, while can also suppress the transfer of carcinoma.It is experimentally confirmed that Radix Et Caulis Acanthopanacis Senticosi polysaccharide has to S180 cellular phospholipids acyl inositol (P1) conversions Significant inhibitory action, its inhibitory action and dosage in it is n-/；Closing property of mouth, this is probably that Radix Et Caulis Acanthopanacis Senticosi suppresses tumor cell proliferation One of mechanism of action.

10th, endocrine regulation：Radix Et Caulis Acanthopanacis Senticosi glucoside has regulation weight body-adrenal cortex function and promotees gonadotropic Effect, can Improve endocrine dysfunction. the thyroid that thyroid causes can be prevented loose, can also prevent methyl sulfur gland pyrimidine from causing first Shape gland atrophy.

11st, it is calm：Mouse peritoneal injection alcohol extracting thing is given, ' can obviously reduce autonomic activitieses, extend the length of one's sleep and convulsions Incubation period.Decoct can improve the excited process of inhibition of brain, strengthen learning and memory, work efficiency.

12nd, antitussive, eliminating the phlegm：Mice aerosol draw cough method experiment show, Radix Et Caulis Acanthopanacis Senticosi extract has obvious antitussive effect；It is little The phenol red method experiment of Mus shows that Radix Et Caulis Acanthopanacis Senticosi extract has obvious phlegm-dispelling functions.

13rd, hepatoprotective：Radix Et Caulis Acanthopanacis Senticosi polysaccharide improves significantly to Mus liver toxicity caused by carbon tetrachloride and thioacetamide work With.26 hepatitis gravis of clinical practice Chi-Wu-Jia Injection in Treating, and random 13 compare, as a result treatment group is to viral hepatitis With obvious therapeutical effect.

(7), Herba Dendrobii extract (Dendrobium officinale extract), is orchid Herba Dendrobii Be dried stem, cold nature, sweet in the mouth return stomach, kidney channel.There are reinforcing stomach reg fluid, nourishing YIN and clearing away heat.It is tired of for impairment of yin body fluid deficiency, xerostomia Yearningly, lack of appetite, after being ill retch, deficiency-heat, poor vision.Herba Dendrobii be partial to YIN nourishing, it is clear in have benefit.Modern pharmacological research shows, ferrum Skin Herba Dendrobii have enhancing immunity, resisting fatigue, mutation, radioprotective, expansion of blood vessels, moistening and cleaning throat, antioxidation, heat clearing and inflammation relieving, blood sugar lowering, Protection gastric mucosa, anti-cancer and cancer-preventing etc..

Chemical composition：Herba Dendrobii containing alkaloid, volatile oil, dendrophnol, polysaccharide, stigmasterol, cupreol, Herba Dendrobii element, Several amino acids and mineral matter and other components.

Pharmacological action：1st, enhancing immunity：Herba Dendrobii water decoction can improve Turnover of Mouse Peritoneal Macrophages to chicken red blood cell Phagocytic function and the low function of the mouse immune that causes of hydrocortisone.It is thin that Herba Dendrobii may additionally facilitate tumor animal macrophage The phagocytic function of born of the same parents, strengthens the propagation and differentiation and NK cytoactives of T lymphocytes, and can significantly improve the serum of tumor animal No matter hemolysin value, point out Herba Dendrobii to non-specific immunity, or specific cellular immunity and humoral immunization work( Can, there is certain potentiation.

2nd, YIN nourishing and the production of body fluid promoting：Herba Dendrobii can be obviously improved the weakness symptom of hyperthyroidism deficiency of YIN mice, and deficiency of YIN mice can be protected to exempt from In death.Herba Dendrobii can also resist inhibitory action of the atropine to rabbit salivation, can promote the normal salivation of rabbit.

3rd, antioxidation：Herba Dendrobii compound preparation can significantly improve superoxide dismutase level, under making lipid peroxide notable Drop, with obvious antioxidation.

4th, cancer-resisting：Research shows, Herba Dendrobii with to hepatocarcinoma and ehrlich ascites cell inhibitory activity, to hepatocarcinoma Mice has different degrees of inhibitory action, and significantly improves thymus and spleen index.Herba Dendrobii ethanol extraction is to Human Lung The cell strains such as cancerous cell, ovary, adenocarcinoma cell, promyelocytic leukemia have significant cytotoxicity, with significantly anti- Cancer antitumaous effect.

5th, expansion of blood vessels：Herba Dendrobii can substantially weaken epinephrine and 5-HT shrinks myocardium vessel and heart contraction in body The effect of mesenteric.

6th, antiviral：Herba Dendrobii water decoction has direct virus-inactivating action, and can suppress the cell after infecting virus Pathological changes, can also directly suppress varicella zoster viruss, the virus to replicating to have growth inhibition effect.

7. immunity is adjusted：Herba Dendrobii decoct can strengthen the phagocytic function of mouse macrophage and recovery hydrocortisone causes little The function of Mus immunocompromised.

8. the two-way function of pair digestive system：, to rabbits' isolated duodenum, low concentration is excited for Herba Dendrobii decoct, high concentration suppression System.Gavage administration can the secretion of facilitating digestion liquid and gastrointestinal motor, suppress atropine and pilocarpine effect, heavy dose makes intestinal Myoparalysis.

9. cataract is prevented and treated：There is retarding action to galactose cataract rat, corneal tunnel incision is made up to 36.8%.Water decoction Gavaging to make crystalline lenses inner cholesterol recover normal, lipid peroxide is substantially reduced, make from cataract crystalline lenses it is higher half Lactose, galactitol and low DPNH I (NADPH), nadide (NADP) substantially return to normal level.It is external right Aldose reductase has non-competitive inhibition.

10. expansion of blood vessels：Herba Dendrobii can substantially weaken epinephrine and 5 one HT shrink myocardium vessel and are contracted in body mesentery The effect of blood vessel.

11. antiviral：Decoct can delay the virogenetic cytopathys of ECHQ11 in tissue culture.

12. antipyretic, analgesias：Dendrobine has certain antipyretic analgesic effect, similar to phenacetin but weaker.

13. other dendrobines can moderate raise Cavia porcelluss and rabbit blood glucose, reduce blood pressure, suppress to breathe and heart contraction, excitement Guinea pig in vitro uterus.

In addition, Herba Dendrobii also has prevents and treats the effect such as cataract, blood pressure lowering, blood sugar lowering, shield stomach, analgesia, antipyretic.

(8), Rhizoma Atractylodis Macrocephalae extract (Atractylodes extract), is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.It is warm in nature, It is bitter in the mouth, sweet.Returns spleen, stomach.There are invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect.For spleen eating less, abdominal distention diarrhea, The functions such as phlegm retention anti-dazzle nervous, edema, spontaneous perspiration, frequent fetal movement.Modern medicine study shows that the Rhizoma Atractylodis Macrocephalae has enhance immunity, protects liver Dirty, cancer-resisting, anti-inflammation, anti-angiocardiopathy, anti-diabetic, diuresis, anti-gastric-ulcer, adjust gastrointestinal function, radioprotective, Help digest, relieving constipation, lose weight, improve the health care of sleep, the function such as resisting fatigue, the bone density that improves, slow down aging.

Chemical composition：The Rhizoma Atractylodis Macrocephalae contains volatile oil, wherein A containing atractylodes lactone, atractylodes lactone B, celery alkane dienone, Rhizoma Atractylodis in oil The compositions such as alcohol, atractylenolqide, glutamic acid, mannan.

Pharmacological action：1st, enhancing immunity：The Rhizoma Atractylodis Macrocephalae can improve lymhocyte transformation rate and natural rosette forming rate, promote Enter cellular immune function, hence it is evident that the content of increase IgG, and the phagocytic function of reticuloendothelial system can be increased, the Rhizoma Atractylodis Macrocephalae can also be bright The expression of aobvious interleukin II (IL-2) receptor for strengthening human peripheral lymphocyte surface.Rhizoma Atractylodis Macrocephalae infusion is filled to mice Stomach, can substantially increase peripheral blood leucocyte (WBC) numeration, increase spleen, thymic weight and lymhocyte transformation rate and macrophage is thin Born of the same parents' phagocytic rate.

2nd, liver protection：In the Rhizoma Atractylodis Macrocephalae, atractylone has obvious inhibitory action to the hepatic injury caused by carbon tetrachloride, can suppress its institute The lipid peroxide of cause is generated, and reduces hepatocellular degeneration necrosis, is declined elevated glutamate pyruvate transaminase, is prevented subtracting for hepatic glycogen It is few, promote the recovery of DNA (deoxyribonucleic acid).

3rd, anti-cancer and inhibiting tumor：The Rhizoma Atractylodis Macrocephalae can reduce the aggressive of cancer cell multiplication rate and cancerous cell, improve body against cancer reaction energy Power and the cytotoxicity to cancerous cell.Separately there is research, Rhizoma Atractylodis Macrocephalae volatile oil is equal to murine sarcoma, ehrlich carcinoma and lymphosarcoma With obvious inhibitory action.And the human esophagus cancer cell strain to tissue culture also has fine specificity active immunity.Therefore, Make with obvious anti-cancer and inhibiting tumor

4th, it is antibacterial：Ovate attractylodes medicinal preparation is to staphylococcus aureuses, viridans streptococcis, Diplococcus pneumoniae, meningococcuss, diphtheria Bacillus, bacillus subtilis also have good inhibiting effect.Rhizoma Atractylodis Macrocephalae decoct is to Bacillus typhi, shigella flexneri, escherichia coli, green pus Bacillus etc. has different degrees of inhibitory action.

5th, antiinflammatory：There is to mice ear method celery alkane dienone and atractylenolqide in the Rhizoma Atractylodis Macrocephalae good antiinflammatory to live Property.

6th, protect gastric mucosa：Rhizoma Atractylodis Macrocephalae volatile oil acetone extract and Rhizoma Atractylodis one monomers can protect gastric mucosa, suppress rat Stress gastric ulcer, hydrochloric acid-ethanol ulcer and pylorus ligation gastric ulcer.β-have anti-experimental character gastric ulcer and suppression gastric juice by folic alcohol The effect of secretion.

7th, gastrointestinal peristalsiss are adjusted：Rhizoma Atractylodis Macrocephalae decoct has dual regulation to gastronintestinal system, can make rabbits infestines irritability Increase, but can substantially resist intestinal tube spasm.Gastric antrum can also substantially be increased, Ache god in jejunum myenteric nerve plexuses The content and gastric antrum myenteric nerve plexuses of Jing, the content under Jejunal mucosa with Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 positive neurons in myenteric nerve plexuses.Ethyl acetate Extract can promote bile secretion.

8th, promote hemopoietic：Rhizoma Atractylodis Macrocephalae decoct subcutaneous injection can promote mouse bone marrow cells erythroid hematopoiesis to organize the growth of born of the same parents.For change The leukocyte decline that therapy or X-ray therapy cause is learned, the Rhizoma Atractylodis Macrocephalae makes which assorted high.

9th, diuresis：Rhizoma Atractylodis Macrocephalae decoct and fluid extract have significantly lasting diuresis to rat, rabbit and Canis familiaris L., can promote electricity The excretion of Xie Zhi, particularly sodium.Baizhu significantly increases can peritoneum aperture, and developing density also substantially increases, and have stronger Peritoneal Stomata regulating and controlling effect, is the active drug for treating ascites.

10th, antioxidation：The Rhizoma Atractylodis Macrocephalae can effectively mitigate lipid peroxidation, reduce content of the lipid to peroxide, can keep away Exempt from destruction of the harmful substance to cellularity and function.In addition, the Rhizoma Atractylodis Macrocephalae can also be improved, SOD is active, and enhancing body is to free radical Scavenging activity, reduces damage of the free radical to body.

11st, slow down aging：Oral Rhizoma Atractylodis Macrocephalae decoct can improve the superoxide dismutase activity of aged mouse erythrocyte, its work Increased with dosage with intensity and increased, while brain activity of monoamine oxidase substantially can be suppressed, and to liver activity of monoamine oxidase without Affect, and erythrocyte autoxidation haemolysis can be suppressed, directly remove free radical, thus the effect with slow down aging.

In addition, the Rhizoma Atractylodis Macrocephalae also has the effects such as expansion of blood vessels, anticoagulation, radioprotective, lipid-loweringing, blood sugar lowering, protection cardiovascular.

(9), Semen Ginkgo extract (Ginkgo extract) is the dry mature seed of Semen Ginkgo section plant Semen Ginkgo.Mild-natured, taste It is sweet, pained, return lung Jing.Relieving asthma with astringing the lung, phlegm reduction of blood circulation promoting, pain relieving etc..For cough and asthma due to lung deficiency, bronchial asthma, reduce gallbladder admittedly Alcohol, remove free radical, increase coronary blood flow, hypertension, hyperlipidemia, cardiovascular and cerebrovascular disease, memory reinforcing, improve brain work( The functions such as energy, antioxidation, defying age, antiinflammatory, antiallergic, anticancer.

Chemical composition：Semen Ginkgo mainly contains flavone compound, bilobalide, Semen Ginkgo polysaccharide, terpene lactoness compound, Duo Zhongwei The bioactive ingredients such as secondary element.

Pharmacological action：

1st, reduce low pressure pulmonary hypertension：Bilobalide B is had no significant effect to normal induced lung hemodynamics, but to low After pressing 3 weeks, pulmonary artery pressure is raised, pulmonary vascular resistance increase, and right ventricle plumpness rat, bilobalide B can substantially mitigate above-mentioned disease Shape.

2nd, mitigate respiratory tract pathological change：After sensitized guinea pig egg protein and normal guinea pig platelet activating factor are excited, During lung group can be made, eosinophilic granulocyte's number increases, and tracheal mucosa epithelial damage comes off, and bronchial smooth muscle shrinks, trachea reactivity Increase, if using bilobalide B in advance, above pathological change is substantially mitigated.

3rd, release bronchus reason spasm：There is to tracheal smooth muscle direct relaxation effect from fruit ethanol extraction, and have anti- The Cavia porcelluss that histamine phosphate, acetylcholine cause are acted in body, isolated bronchia spasm, can be prevented Guinea Pig Histamine asthma and be sent out Make.

4th, insecticide is reduced to cell injury：It is reported that, Semen Ginkgo leaf extract causes Pc12 cell injury to have N,N'-dimethyl-.gamma..gamma.'-dipyridylium Protective effect.Epidemiologic data shows that environmental factorss such as herbicide, agrochemical are relevant with gold gloomy disease generation is afraid of.Dihydro pyrrole Pyridine class herbicide BAICAO Fructus Citri tangerinae (PQ) is a kind of common pesticides, its structure and neurotoxin (MPP+ similar neurotoxin).Grind Study carefully and show, Semen Ginkgo extract has certain protective effect to the cell injury that PQ is induced.Its mechanism of action may make Caspase-3 activation weakens, and expression is reduced, and so as to reduce breaks down proteins and DNA break, reduces apoptotic generation.

5th, antiinflammatory：The Mus ear chafing disease that Folium Ginkgo flavone is induced to Fructus Crotonis has inhibitory action.

6th, antibacterial：Semen Ginkgo decocting liquid has inhibitory action to staphylococcus aureuses, dysentery bacterium and the green bacillus of pus.

7th, antiviral：Folium Ginkgo crude extract has inhibitory action to Epstein-Barr virus, and its effective ingredient is bilobetin.

8th, anticancer：Active component in Folium Ginkgo can prevent or reverse the fibre modifications of each tissue, reduce inflammatory disease patients Deng the abnormal rising of active immunity disease gamma globulin and immunoglobulin, for treating leukemia and solid tumor, because of it The effect of anti-cancer chemotherapeutic agents can be improved, untoward reaction is reduced so that the cancerous cell of resistance to cell toxicity medicament is more sensitive to chemotherapeutics Effectively.

9th, remove free radical：Semen Ginkgo leaf extract has scavenging hydroxyl, superoxide anion and nitric oxide production effect, has Anti-lipid peroxidation is acted on.

10th, anoxia enduring：Semen Ginkgo leaf extract not only can change blood flowing characteristic, and can carry and do hypoxia-bearing capability. Its mechanism of action is to increase cerebral blood flow with to improve anoxia relevant to brain energy metabolism.

Additionally, Folium Ginkgo also has blood fat reducing, preventing and treating cardiovascular and cerebrovascular disease, blood pressure lowering, expansion of blood vessels, increase blood flow, increasing The effects such as strong memory, anti-cerebral ischemia, senile dementia prevention and cure, slow down aging, beauty.

11st, strengthen immunologic function：Semen Ginkgo whether In vitro culture or vivo medicine-feeding, can promote by Con A Concanavalin The breeder reaction of the tumor-bearing mice splenic T lymphocyte and bone-marrow-derived lymphocyte that are induced with LPS respectively, points out Semen Ginkgo little to lotus knurl Mus cellular immunization and the low state of humoral immune function, have significant potentiation.

12nd, eliminating the phlegm：Alcohol extracting thing improves can the tracheal mucosa secretory function of rat, have directly loose to tracheal smooth muscle Effect.Semen Ginkgo water extract increases can the phenol red excretion of respiratory tract, have significant phlegm-dispelling functions to mouse peritoneal injection.

13rd, expansion of blood vessels, increase blood flow：Semen Ginkgo extract can cause guinea pig in vitro, heart coronaries vasodilation to increase Cerebral blood flow.Its mechanism of action is that Semen Ginkgo total flavones have obvious inhibiting effect to Angiotensin-Converting activity, so as to suppress Small artery shrinks, and increases blood flow.Separately there is research, Semen Ginkgo total flavonoid glycoside can reduce pushing away Arterial system periphery resistance, so as to increase Blood flow.

(10), Bulbus Lilii extract (Lily Bulb Extract), is liliaceous plant endoplasm bulb.Cold in nature, sweet in the mouth, returns The heart, lung meridian.With nourishing the lung to arrest cough, the effect of clearing away heart-fire for tranquillization.For symptoms such as yin chronic cough, sputum mixed with blood, insomnia and dreamful sleeps.For The symptoms such as deficiency of YIN chronic cough, sputum mixed with blood, dysphoria palpitates with fear, insomnia and dreamful sleep, absentminded.Modern medicine study shows that Bulbus Lilii has Enhancing immunity, resisting fatigue, mutation, moistening and cleaning throat, anoxia enduring, improve the health care of sleep, blood fat reducing, blood sugar lowering, anticancer, relieving constipation, antiallergic, The functions such as calmness, anti-gastric-ulcer, antioxidation, slow down aging, eliminating the phlegm, relieving cough and asthma.

Chemical composition：Containing alkaloid, steroidal glycoside, cupreol, daucosterol, various sugar, starch, protein, fat Deng composition.

Pharmacological action：1st, nourishing YIN and moistening the lung, Bulbus Lilii have significant guarantor to adrenal cortex function exhaustion caused by meticortelone Shield is acted on.And DNFB induced mice delayed hypersensitivity reaction can be suppressed, therefore there is nourishing YIN and moistening the lung, tonifying the lung gas etc. to make With.

2nd, relieving cough and asthma：Bulbus Lilii decoct has the cough-relieving effect of coughing to the mouse cough that ammonia causes, and can make mouse lung perfusion stream Amount increases.And the asthma of Bufo siccuss can be caused to antihistaminic.

3rd, eliminating the phlegm：Phenol red colorometric assay shows that Bulbus Lilii has significant phlegm-dispelling functions.Its mechanism of action is to strengthen breathing Excretion function, while increasing the phenol red amount of mucous membrane excretion secretion.

4th, immunity is adjusted, Bulbus Lilii polysaccharide is remarkably improved phosphamide hypoimmunity mice peritoneal macrophage phagocytosis percentage Rate and phagocytic index, promote hemolysin and hemolysis plaque to be formed, promote lymphocyte transformations.

5th, resisting fatigue：Bulbus Lilii can be obviously prolonged the swimming time of mice, with anti-fatigue effect, have strong effect.

6th, antiallergic：Bulbus Lilii Aqueous extracts can substantially suppress anaphylaxiss caused by dinitrochlorobenzene to mouse gavaging.

7th, anti-hypoxia：Bulbus Lilii Aqueous extracts can extend mice normobaric hypoxia to mouse gavaging, and caused by isoproterenol, cardiac muscle lacks Caused by the anoxia and thyroid of oxygen increase, YIN-deficiency type mice is often in the time-to-live of anoxia.

1st, it is calm：Mouse gavaging Bulbus Lilii aqueous extract is given, pentobarbital sodium length of one's sleep can be obviously prolonged, and make to measure under threshold Pentobarbital sodium sleep rate is significantly improved, and points out Bulbus Lilii to have obvious sedation.

2nd, peripheral leukocytes are raised：Mouse peritoneal injection cyclophosphamide, causes experimental leukopenia, and Bulbus Lilii is to little Mus gavage can make peripheral blood leukocyte number significantly raised, prevent caused by cyclophosphamide leukopenia.

3rd, cough-relieving, relieving asthma：Bulbus Lilii decoct has antitussive action to making the mouse cough that ammonia causes, and can make mouse lung perfusion stream Amount increases, and the Bufo siccuss asthma that can cause to antihistaminic, with significant function of relieving cough and calming asthma.

4th, mind tranquilizing and the heart calming：Bulbus Lilii enters heart channel, cold nature, energy relieving restlessness that clears away heart-fire, mind tranquilizing and the heart calming, for calentura waste heat tip, god Think in a trance, insomnia and dreamful sleep feels depressed, the disease such as susceptible to anger wound is intended to, cries.

5th, gastric mucosa, anti-gastric-ulcer are protected：Bulbus Lilii water decoction causes stomach to burst to subcutaneous injection indometacin carboxymethyl cellulose The rat of infectionss gavages, and gastric mucosa pathological changes can be made substantially to mitigate, and can significantly inhibit its TXA₂Metabolite TXB₂Liter It is high.There is obvious protective function to indomethacin induction rat gastric ulcer gastric mucosal lesionss.

6th, cancer-resisting：Research shows that Bulbus Lilii contains various alkaloids, has preventive effect to leukopenia, can rise High leukocytic number, has therapeutical effect to leukopenia after chemotherapy and radiation treatment.Bulbus Lilii can also promote in vivo and increase Plus mononuclear cell system phagocytic function, improve the humoral immunization ability of body.Therefore, Bulbus Lilii has preferably anti-to kinds cancer Control effect.Bulbus Lilii is usually used in the auxiliary treatment of the cancers such as leukemia, pulmonary carcinoma, nasopharyngeal carcinoma in clinic.In addition, the biology contained by Bulbus Lilii Alkali can also anticancer increment.

(11), Rhizoma Curcumae Longae extract (Curcumin P.E), are the rhizome of zingiberaceous plant Rhizoma Curcumae Longae.It is warm in nature, acrid in the mouth, hardship.Return Liver, spleen channel.With blood-breaking, inducing menstruation to relieve menalgia effect.For chest side of body shouting pain, amenorrhea.Rheumatism shoulder arm pain, tumbling down swell and ache. Modern pharmacological research shows, Rhizoma Curcumae Longae has lowering blood pressure and blood fat, suppresses platelet aggregation, resist myocardial ischemia, the liver protecting, carry High immunity, antiinflammatory, antifungal, antiviral, antioxidation, mutation, function of gallbladder promoting, resisting fatigue, improve the health care of sleep, relieving constipation, slow down aging, Cancer-resisting etc. is acted on.

Chemical composition：Containing curcumin, demethoxycurcumin, Bisdemethoxycurcumin, volatile oil (turmerone, zingiberene, Borneolum Syntheticum, phellandrene) etc..

Pharmacological action：1st, enhancing immunity：Rhizoma Curcumae Longae can promote rat spleen lymphocytes mitosiss, change mice spleen lymph Cell quantity, the detached polysaccharide of Rhizoma Curcumae Longae water extract, can stimulate reticuloendothelial system, in addition, the lipopolysaccharide in Rhizoma Curcumae Longae has exempting from Epidemic disease facilitation.

2nd, mutation：Rhizoma Curcumae Longae extract can reduce the mutagenic action of capsaicin, and relevant with dosage.Curcumin is to environment Prominent agent, the such as mutation caused by the condensate of cigar, Yan grass and removal xylene etc. is caused also to have inhibitory action.

3rd, protect gastric mucosa：Curcuma powder can increase content of viscous albumen in gastric juice, play a part of to protect gastric mucosa.

4th, resist myocardial ischemia：Rhizoma Curcumae Longae extract gavage, can resist Rat Ecg S-T, T that pituitrin intravenous causes Ripple changes.Curcumin is gavaged can strengthen mice's myocardial nutritional blood flow.

5th, the liver protecting：Curcumin, demethoxycurcumin and Bisdemethoxycurcumin, have the recessed chlorination carbon of antagonism and Galactosamine is to Rat Primary Hepatocytes culture to caused damage.The ethanol extraction of Rhizoma Curcumae Longae is to carbon tetrachloride and galactosamine The toxicity of the Rat Primary Hepatocytes for causing also has antagonism.Curcumin can also mitigate the hepatic injury caused by acetaminophen.

6th, antiinflammatory：The rat and mice foot plantar that curcumin Carrageenan causes has obvious inhibitory action.Curcumin sodium The isolated guinea pig ileum for suppressing the induction of nicotine, acetylcholine, 5-hydroxy tryptamine, Barium monoxide and histamine reversibly shrinks, class It is similar to nonsteroidal anti inflammatory drugs.

7th, antifungal：Rhizoma Curcumae Longae volatilizees Shan to trichophyton, trichophyton gypseum, wadding：Volt epidermophyton and mortar color：Read ball The dermatophytess such as bacterium, microsporum canis have different degrees of inhibitory action.

8th, antiviral：Rhizoma Curcumae Longae water decoction can extend its life span to the mice of virus inoculation.To hepatitis B virus deoxidation core Ribosomal ribonucleic acid has moderate inhibitory action.But add carbon tetrachloride hepatic injury invalid viral hepatitis.

9th, antioxidation：Curcumin has the lipid peroxidation for suppressing metal ion induction, suppresses cellular oxidation modification low close Spend lipoprotein and DNA is protected from effects such as lipid peroxide damages.Curcumin also has suppression nitrous acid induced oxidation blood red Albumen, the not oxidized effect into high ferro Lactoferrin of protection hemoglobin.Curcumin antioxidative mechanism is made by inhibitory activity The generation of oxygen, eliminates free radical and peroxide and plays antioxidation.

10th, cancer-resisting：Cancer is to endanger a big killer of human health, how giving protection against cancer become the world today with anticancer The focus of medical research.According to substantial amounts of research, curcumin mainly suppresses some mutagenic agenies, the tumor development mistake that carcinogen causes Links in journey.Research discovery is carried out to the mechanism of action of curcumin, it can remove various oxides, including the activity of NO, Except the activity for removing free radical also finds curcumin energy and Ca²⁺Interact with the complex of calcium protein.Curcumin antitumor Effect be by protecting normal cell to resist various carcinogenic factors and suppress tumor cell to develop each stage and work.Always It, curcumin can suppress in different phase, delay and reverse Carcinogenesis, show complicated anticancer and antimutagenic activity.According to most New result of study shows the curcumin of 8.5-136umol/L in vitro to Human Gastric Cancer MGC803, hepatocarcinoma Bel17402, white blood The cancerous cell such as sick K562 have significant lethal effect, and have proliferation function to anti-epidermal growth factor, and this explanation curcumin has The effect of cancerous cell is killed directly.According to another report, the skin carcinoma that curcumin causes to various carcinogeies, breast carcinoma and digestive tract cancer Disease has stronger preventive effect.

(12), Fructus Amomi Rotunduss extract (Cardamom extract), also known as semen myristicae, are that zingiberaceous plant perennial herb is planted The dry mature fruit of thing Fructus Amomi Rotunduss, warm in nature, acrid in the mouth, return lung, spleen, stomach.The effects such as having removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting.For Treatment dampness taste, retention of damp leading to blockage of QI, the thoracic cavity abdominal distention of Deficiency and coldness of spleen and stomach, anorexia, gastric disorder causing nausea vomiting, deficiency and coldness chronic diarrhea, chamber abdomen cold type of pain, The diseases such as appetite-stimulating indigestion-relieving, dyspepsia, stomachache.Modern pharmacological research shows that Fructus Amomi Rotunduss have enhancing immunity, the liver protecting, resist Bacterium, antiulcer, anti-angiocardiopathy, eliminating the phlegm, relieving asthma, endocrine regulation, it is aid digestion, calm, improve the health care of sleep, cancer-resisting etc. is made With.

Chemical composition：Fructus Amomi Rotunduss are containing compositions such as 1,8 eucalyptus oils element, 4- terpineol, α-terpinol, terpinene-4-alcohols.

Pharmacological action：1st, the liver protecting：Fructus Amomi Rotunduss have to the Liver Damage in Rats of lipopolysaccharide and D-galactosamine combined induction Very strong protective effect.

2nd, antibacterial：Fructus Amomi Rotunduss quintessence oil can suppress staphylococcus aureuses, escherichia coli, Bacillus typhi, vibrio cholera and not The old Hayes bacterium of family name, the also significantly effect of anti-tubercle bacillus.

3rd, antiulcer：Fructus Amomi Rotunduss ethanol extraction can significantly reduce the rat stomach that pylorus ligation and Cold stress reaction cause Mucosa injury, substantially can suppress to reduce gastric acid output, and the secretion inhibitor protection cytosiies of alcohol extracting thing, are its antiulcer masters Want mechanism.

4th, improve function of intestinal canal：Fructus Amomi Rotunduss quintessence oil can be releived the activity of the external small intestinal of numb acid Canis familiaris L. and the work of the external intestinal tube of rabbit It is dynamic.The intestinal segment that Fructus Amomi Rotunduss quintessence oil can also cause to acetylcholine and barium chloride shrinks, and also has the effect of releiving very well.

5th, eliminating the phlegm：Foundation ligroin extraction has good phlegm-dispelling functions to rabbit, increases can trachea glandular secretion, volatilization Property part can directly stimulate broncheal gland, and volatile part is then by the reflection generation effect of gastric mucosa.

6th, it is calm：Fructus Amomi Rotunduss volatile oil can extend the length of one's sleep that chickling is caused by ethanol lumbar injection, can especially extend The sound sleep time, the sedation of Siam cardamom oil may with improve the health care of sleep it is relevant.

7th, cancer-resisting：Fructus Amomi Rotunduss methanolic extract is found with very strong active anticancer to mouse peritoneal injection.Semen Vignae Cylindricae The cool Mouse Uterus cancer to the induction of 3-MECA alkene has certain inhibitory action.Mouse skin to dimethylbenzanthracene induction Papilloma also has inhibitory action.Recent study shows that Fructus Amomi Rotunduss can strengthen the Detoxication of liver, is potential cancer Learn preventive；In addition, Fructus Amomi Rotunduss water extract can strengthen the activity of glutathione transferase and glutathion reductase, hence it is evident that carry In high liver and other target tissues, GST is active.Therefore, the effect with anti-cancer and cancer-preventing.

8th, it is aid digestion：Fructus Amomi Rotunduss extract can increase pepsic activity, have good digestion-aid effect.

In addition Fructus Amomi Rotunduss also have antidiarrheal, relieving asthma, tuberculosis, promote the effect such as bile secretion, lithodialysis, anti-inflammatory and antalgic.

(13), Rhizoma Zingiberis Recenss extract (Ginger extract), rhizome of the Rhizoma Zingiberis Recenss for zingiber, slightly warm in nature, acrid in the mouth. Returns spleen, stomach, the heart, lung, kidney channel.There are relieving the exterior syndrome by diaphoresis, warming the lung to relieve cough, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing, alleviation carsickness and gestation reaction etc. Effect.Modern study shows that Rhizoma Zingiberis Recenss have enhancing immunity, antioxidation, the liver protecting, regulation gastrointestinal function, antiallergic, antibacterial Antiinflammatory, improve cardiac function, improve memory, antiulcer, preventing or arresting vomiting, calmness, hypnosis, convulsion, antipyretic, analgesia, mutation, anti-cancer Anticancer, blood fat reducing etc. are acted on.

Chemical composition：Rhizoma Zingiberis Recenss are peppery containing volatile oil, zingiberol, zingiberene, gingerol, gingerol, the peppery alcohol of 4- Rhizoma Zingiberis Recens, the peppery alcohol of 8- Rhizoma Zingiberis Recens, 10- Rhizoma Zingiberis Recens The composition such as element, the peppery alcohol of 3- Rhizoma Zingiberis Recens, the peppery ketenes of 6- Rhizoma Zingiberis Recens, aminoacid, resinoid.

Pharmacological action：1st, antiulcer：Rhizoma Zingiberis Recenss have the effect of protection Gastric Mucosal Cells containing zingiberene, and Rhizoma Zingiberis Recenss decoct two-way can be adjusted The secretion of section dog gastric acid and gastric juice, significantly inhibits salt acidic and stressing gastric mucosa lesion.Its effect can be closed with gastric mucosa is promoted Into with release endogenous prostaglandin it is relevant.

2nd, promote gastrointestinal function motion：(4-hydroxy-3-methoxyphenyl)ethyl methyl ketone contained by Rhizoma Zingiberis Recenss can make intestinal tube loose, wriggle and reduce, another aspect Rhizoma Zingiberis Recenss pair Digestive tract has certain stimulation, can make intestinal tension force, the rhythm and pace of moving things and wriggle to increase.

3rd, the liver protecting：Gingerol, zingiberol in Rhizoma Zingiberis Recenss etc. suppress to make with significant to hepatic injury caused by carbon tetrachloride With.

4th, treat Nausea and vomiting：Caused by Rhizoma Zingiberis Recens extractum suppression peripheral emetic copper sulfate, the vomiting of dog, (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone mix Thing can also suppress the emetic action caused by copper sulfate.

5th, it is calm：Hypnosis, convulsion, oil of Rhizoma Zingiberis Recens can substantially suppress mice voluntary activity, extend pentobarbital sodium sleep Time, resist the convulsions that causes of penta bar tetrachloro, the site of action of Central nervous in spinal cord level above, with obvious calmness Hypnosis anticonvulsant action.

6th, it is antipyretic：Rhizoma Zingiberis Recenss are had no significant effect to mice and rat normal body temperature, but oil of Rhizoma Zingiberis Recens, 6- shogaols or 6- ginger ketenes Rat to injecting yeast heating has obvious refrigeration function.

7th, ease pain：Oil of Rhizoma Zingiberis Recens, shogaol can substantially suppress large and small Mus acetic acid twisting reaction, and it is anti-that prolongation hot plate method licks metapedes Between seasonable.

8th, antiinflammatory：Rhizoma Zingiberis Recenss are swollen enough to rat Ovum Gallus domesticus album and formaldehyde significant inhibitory action.Oil of Rhizoma Zingiberis Recens is to rat cotton balls Caused by granuloma, dimethylbenzene induced mice auricle edema, histamine acetic acid, capillary permeability strengthens also has significant suppression to make With.Its antiinflammatory action suppresses prostate synthesis relevant with which.

9th, antiallergic：Rhizoma Zingiberis Recens extract has anti-allergic effects, can prevent anaphylactic shock, prevents some fish proteins The urticaria for causing.

10th, antitussive：Shogaol and ginger ketenes have antitussive effect.

11st, anticancer：Rhizoma Zingiberis Recenss juice can anticancer growth and diffusion, Rhizoma Zingiberis Recens extract can also mitigate the pair of anticarcinogen Effect.Contained polyprotic acid panaxitriol in Rhizoma Zingiberis Recenss, can not only make the growth of malignant cell reduce 50%, and can suppress The diffusion of cell.Its mechanism of action, polyprotic acid panaxitriol can reduce cell permeability of the membrane, so as to prevent malignant cell Propagation.In addition, according to external, German Research finds, Rhizoma Zingiberis Recenss can to a certain extent can anticancer grow.To with food The cancer patients such as road cancer, gastric cancer, ovarian cancer, adhere to twice daily with hot Jiang Shui on behalf of the tea, pain relieving can be played and alleviate the state of an illness Effect.Containing external report, the recent studies on of one, the U.S. shows that the contained 6- zingiberols with distinctive odor, can suppress in Rhizoma Zingiberis Recenss Growth of Colon Cancer Cells in experimental mouse and human body.

12nd, defying age：Many researchs are thought：The main cause for causing human senility is that intracellular free radical can be with molecule Oxygen forms peroxidating base destruction cell, so as to cause aging.Therefore, during mankind aging, oxidation caused by free radical institute Reaction is arch-criminal.And the gingerol in Rhizoma Zingiberis Recenss has excitation to respiratory center, vasomotor center and heart, and can produce A kind of defying age material of life, so as to suppress cylinder super-oxidation lipid, prevents the formation of lipofuscin pigment and senile plaque, therefore can play Good anti-aging effects.

In addition, Rhizoma Zingiberis Recenss also have aid digestion, cleaning moisture and dispelling cold, promoting blood circulation, detumescence, blood circulation promoting, cholesterol reducing, increase food The effects such as desire, anticoagulation, pre- preventing thrombosis, prevention cholelithiasis, promotion wound healing, blood fat reducing.

(14), Green tea extract (Tea polyphenol), leaf of the green tea for Theaceae plant, cool in nature, sweet in the mouth, hardship, GUIXIN, liver, spleen, lung, kidney channel.Have tonification, refresh oneself, except rushing down, help digestion, diuresis relieving constipation, removing toxic substances, heat clearing and inflammation relieving, resolving sputum the effects such as. Modern pharmacological research, green tea energy enhancing immunity, resisting fatigue, antiviral, radioprotective, hepatoprotective, mutation, regulating intestinal canal flora, Antioxidation, slow down aging, cancer-resisting, lowering blood pressure and blood fat, blood sugar lowering, fat-reducing, antibacterial, cholesterol reducing, suppression arteriosclerosis With platelet build up etc. function.

Chemical composition：Green tea protein, aminoacid, tea polyphenols, theanine, tea pigment, caffeine, dietary fiber, Ye Lv Element, beta-carotene, multivitamin and mineral matter and other components.

Pharmacological action：1st, enhancing immunity：Reduction of the green tea soak to leukocyte count and lymphocyte absolute number has bright Aobvious antagonism.To peripheral α-acetic acid tea ester positive percentage or absolute number, in severe suppression group, there were significant differences, and The lymph caused by cycli phosphate amide can be kept to turn response inhabitation and to give tea group sheep red blood cell (SRBC) hemolysin, antibody horizontal is above right According to group.Therefore, green tea has fine immunity potentiation.

2nd, mutation：Antioxidant content in green tea extract and Folium Camelliae sinensis has₁And Bap The Salmonella typhimurium back mutation effect of induction, this antioxidant can suppress Aflatoxin B₁With the V79 of Bap inductions Cytogene forward mutation, and Aflatoxin induction V79 cells SCE and chromosome very become.The effect machine of green tea mutation In with remove free radical, the suppression and blocking to carcinogenic and mutagenic matter, improve immunity of organism physical ability, prevent and suppression poison The effect such as cell and intercellular infection is relevant.

3rd, anti-radiation：Feeding dog can make green tea extract⁶⁰The acute radiation disease symptoms occurred after Co lines irradiation dog, bleeding portion Position, wbc value, platelet count, the change of hemoglobin content all substantially mitigate compared with matched group.Green tea lipopolysaccharide also has radioprotective Damaging action.

4th, the liver protecting：Research shows that the tea polyphenols in green tea have antivirus action, with the work for preventing and treating chronic hepatitiss With.Chronic hepatitiss can cause liver cirrhosis and hepatocellular carcinoma or malignant liver.Research shows that tea polyphenols have antiviral and resist Cancer attribute, can prevent hepatoviruses from entering liver cell, therefore act on significant the liver protecting.

5th, cancer-resisting：Recent study shows that many kinds of substance such as tea polyphenols, tea pigment in green tea is prevented with stronger Cancer antitumaous effect.Green tea extract has obvious inhibitory action to ehrlich carcinoma, sarcoma.The stomach cancer cell of In vitro culture is had Good lethal effect.Pathologic finding discovery, the division number of green tea energy anticancer, and have obvious lymphocytic infiltration； Its antitumaous effect is relevant with body against cancer immunologic function is improved.According to foreign countries, a Japanese recent studies on shows, drinks 5 glasss daily Or more green tea can reduce by 50% cancered risk.American-European multinational research confirms, green tea can to anti-breast cancer, gastric cancer, The danger that the cancers such as colon cancer, pulmonary carcinoma, carcinoma of prostate, cancer of pancreas occur.

6th, antiviral：Polyphenol in green tea has obvious inhibiting effect to the HIV-1 viruses of Hg lymphocytic inflammations, shows green Tea has obvious antiviral activity effect.In addition, green tea extract may also suppress the cellular infiltration of influenza virus mice, pneumonia is made Mitigate, extend survival time of mice, its mechanism is that the IL-1 for suppressing IFN inductions is generated, and adjusts body anti-to the immunopathogenesis of influenza Should.According to another report, the tea polyphenols in green tea are taken 5 months, and flu episode rate reduces by 75%.

7th, antibacterial：Green tea has certain inhibitory action to meningococcus.Green tea extract is in test tube to various dysentery Shigella and Salmonella, staphylococcus aureuses, beta hemolytic streptococcuss, diphtheria corynebacterium, anthrax bacteria, Fructus Citri tangerinae grass bar Bacterium, Bacillus proteuss, bacillus pyocyaneus etc. have inhibitory action.

8th, antioxidation：There is Tea Polyphenols scavenging activated oxygen to act on, caffeine, cachou extract, table catechu in green tea Essence has stronger antioxidation, can substantially suppress hypoxanthine and xanthine oxidase reaction, and its inhibitory action is than SOD more By force.

9th, defying age：Green tea extract can suppress the lipid oxidation of liver cell mitochondria, life span of drosophila melanogaster test result indicate that, Green tea has significant anti-aging effects.

(15), spirulina extract (Spirulina extract), spirulina are that a kind of glaucous many cells are thread Algae, belongs to the beads Mu Chan sections Spirullina of cyanophyceae, and with hard masses softening and resolving, the disease that disappears diuretic function, spirulina is a kind of important Nutraceutical, its unusual food of nutritive value only certain single or certain several nutrient containing row, but complex nutrients sources, It is that a kind of human body that comprehensively can provide gives birth to existing function and the superior biological nutrient pack needed for organizational structure substantially.The nutrition work(of spirulina Can be with effect of the various chronic diseases of prophylactic treatment, more because it can provide nutrition in a balanced way, to tricky ＜ diet in a balanced way Structure helps Ju to act on.According to modern scientific research, spirulina has resisting fatigue, enhancing immunity, radioprotective, antioxidation, guarantor Cut off the feet：, lowering blood pressure and blood fat, blood sugar lowering, protection heart coffee. manage, lose weight, prevent anemia, constipation, gastric ulcer, antioxidation, delay to decline Always, the health care such as anticancer.

Chemical composition：It is spirulina rich in proteins, ten several amino acids, many including human body 8 kinds of essential amino acids, algaes Sugar, carbohydrate, cellulose, unsaturated fatty acid, rise superoxide dismutase, chlorophyll, carotenoid, calcium, ferrum, zinc, Magnesium, germanium, selenium, B. carotene, vitamin B1, vitamin B2, vitamin B6, Vitamin B12, vitamin C, Vitamin E, Ni Ke The materials such as acid, Folic Acid, pantothenic acid.

Physiological function：1st, enhancing immunity：Spirulina can improve animal spleen index, stimulate spleen lymphocyte proliferation, increase The phagocytic function of strong macrophage, promotes antibody the way of production, from organ, cell, humoral immunity level, improves immunologic function. Generation of the spirulina polysaccharide to splenocyte polyclonal antibody (1gM and 1zG) also has facilitation.Spirulina polysaccharide is in suckling in a word Have proven to, with specific immune function and non-specific immunity is strengthened, mouse peritoneal can be greatly enhanced huge in zoopery Bite the phagocytic activity of energy and to cellular immunization and the function of humoral immunization.

2nd, prevent and treat fatty liver：Spirulina has blood pressure lowering, drop ... the towel ' function such as fat, thus to fatty g：I：Preventing and treating is played Important effect.Its mechanism make fat in vivo accumulation be intended to skin-F muscular tissues, so as to reduce fat liver, heart, The chance accumulated on blood vessel and film, at the same time, the cholesterol level in blood is substantially reduced, and plays anti-well to fatty liver Control and make river.

3rd, radioprotective：Spirulina has very strong capability of resistance to radiation.Polysaccharides can significantly inhibit laboratory animal spleen lymph Apoptosis rate, reduces the wide reaction of withering of cell, so as to guarantor's effect is played to radiation-induced damnification of immunity function.

4th, improve anemia：Spirulina contains ferrum and Vitamin B12, is 20 times of normal food, can effectively strengthen hemopoietic machine Can, more to losing blood, low sanguinin anemia and iron deficiency anemia have significant curative effect.

5th, toxin expelling：Spirulina is the doffer that disappears of human body harmful toxic matter, and experiment shows that spirulina can exclude people's body accumulation Radiant, dispels the toxic and side effects of heavy metal, virus and medicine.

6th, resisting fatigue, anoxia enduring：Spirulina can reduce the mda content in mouse heart and cerebral tissue, increase erythrocyte And brain SOD vigor, serum lactic level is improved, extends the swimming time of mice.

7th, antiviral：Spirulina polysaccharide has obvious inhibitory action to bovine immunodeficiency viruss growth.It can prevent virus Duplication in parasitic cell, and effectively prevent Virus entry normal cell.

8th, antitumor：It is reported that, spirulina polysaccharide has stronger immunoregulation effect to Turnover of Mouse Peritoneal Macrophages, can make Which suppresses one of important mechanisms of tumor.Confirmed according to Japanese biological study is studied, contain physiologically active thing in spirulina, can press down Growth of tumour cell processed, and energy：Battle array tumor cell is caught up with into impasse, and inducing tumor cell is committed suiside, separately had been reported that, to liver tumor Experiment mice orally authorize phycocyanin, survival rate is significantly improved than matched group, and lymphocyte activity is apparently higher than matched group And normal mouse, additionally, also have the liver protecting, antioxidation, slow down aging, prevent gastric ulcer, protection cardiovascular the effects such as.

9th, protect the intestines and stomach：Research shows that most of patients with gastric disease hyperchlorhydria causes gastritis, gastric ulcer, and spiral Algae is basic food, and spirulina contains abundant vegetable protein and chlorophyll, beta-carotene, and these nutrient substance are to gastric acid Neutralization and gastrointestinal tract mucosa reparation, regeneration and normal secretions function are extremely effective, are particularly well-suited to the intestines and stomach patient.Spirulina plalensiss Gavage, to indomethacin (indometacin) type, dehydrated alcohol experimental gastric ulcer model have significant protective effect；Can drop The incidence rate and reduction ulcer number of low pyloric ligation ulcers rat ulcer model, also has certain inhibitory action to gastric secretion, can Accelerate the healing of chronic acetic acid type rat gastric ulcer.

10th, enhancing immunity：According to another report, spirulina polysaccharide can make the serum hemolysin of mice improve 39.5-98%, abdomen The phagocytic rate of chamber macrophage improves 32.5-51.5%, and phagocytic index improves 0.9-1.8 times, and T lymphocyte numbers provide 46.8- 87.7%, the marrow lymphocyte dense arrangement of spleen, macrophage showed increased in red pulp, acid α-naphthyl acetate esterase are positive Lymphocyte increases 7.3-12.8%.Therefore, spirulina has the significant effect for strengthening immunologic function.

11st, radioprotective：Making, radiotherapy is forward and backward to have significant radiation resistance to Mouse oral spirulina, can improve The survival rate of mice.

12nd, antibacterial：Spirulina plalensiss have inhibitory action to gram positive bacteria, the blunt top spiral shell containing lipid and triterpenoid compound Rotation algae ethanol extraction bacteriostatic activity is most strong.

(16), malt extract (Malt Extract), are the mature fruit of grass Fructus Hordei Vulgaris, Jing germination dryings And obtain.It is mild-natured, sweet in the mouth, returns spleen, stomach.There are promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, galactopoiesis relieving distension.For dyspepsia, gastral cavity abdomen The diseases such as distending pain, spleen eating less, inappetence, milk stasis, distending pain of the breast, puerpera's ablactation.Modern medicine is managed research and is shown, Fructus Hordei Germinatus With facilitating digestion, the liver protecting, resisting fatigue, improve intestinal microbial population, hypnotic, enhancing development, fat-reducing, blood sugar lowering, Improve the note effect such as power, anticancer.

Chemical composition：Fructus Hordei Germinatus amylase-containing, protease, protein, maltose, dextrinosan, vitamin B, choline, The compositions such as sweet foline, lecithin, aminoacid, maltol, dextrin.

Pharmacological action：1st, facilitating digestion：Starch in the presence of α and beta amylase can be analyzed to maltose and dextrin, have Beneficial to absorption of human body.Fructus Hordei Germinatus decoct has slight facilitation to gastric acid and albumen enzyme secretion.Contained amylase and vitamin B There is digestion-aid effect.

2nd, regulating intestinal canal flora：Dextrinosan contained by Fructus Hordei Germinatus has one to the intestinal microbial population of mice and tested crowd Fixed adjustment effect, to mice and HE bacillus bifiduss, the lactobacilluss in people's intestinal have promotion proliferation function, have suppression The effect of people's intestinal bacillus perfringens all living creatures's length.

3rd, antifungal：Fructus Hordei Germinatus contain horbatine A and B has antifungal active function.

4th, antioxidation：Fructus Hordei Germinatus be rich in phenolic compound, have stronger antioxidant activity and stronger reducing power and metal from Sub- chelant ability, can scavenging activated oxygen, hydroxy radical and superoxide anion, suppress linoleic acid autoxidation, therefore, Fructus Hordei Germinatus extract Thing has preferable antioxidant effect.

5th, chronic hepatitiss are treated：Fructus Hordei Germinatus powder is made syrup and is taken orally, each 10ml, and 3 times a day, continuously takes, and effective percentage reaches 67.1%, the alanine aminotransferase and liver enlargement of effective case have different degrees of improvement.

6th, anticancer：Fructus Hordei Germinatus extract has different degrees of improvement result to kinds cancer.Have an external report, scientist from Fructus Hordei Germinatus extract a kind of medicine for the treatment of cancer " A Wei Ma Er ", and the medicine can prevent cancer cell metastasis, and can strengthen patient's machine Body function of immune system, is used in combination with the cancer therapy drug such as other cytostatic agents, can play and control curative effect well Really.

Additionally, Fructus Hordei Germinatus also have fat-reducing, blood fat reducing, blood sugar lowering, control infantile dyspepsia, lactogenic, galactopoiesis etc. act on.

(17), sulforaphen (Sulforaphane), also known as Sulforaphane, are the presence of the one kindization in crucifer Compound, is the best active components of plants of anticancer effect found in vegetable.Scientific research finds that sulforaphen has antioxygen Change, anticancer, antiinflammatory, protection pulmonary, the effects such as detoxify, prevent and treat gout.

Pharmacological action：1st, cancer-resisting, scientific research find that sulforaphen has various biological effect, and it can suppress swollen Tumor cell growth, inducing apoptosis of tumour cell.Sulforaphen is to have now been found that effect is most strong, effect in all natural anti-cancer materials Best active component, its unique anticancer function, it can cause the apoptosis and cell block of cancerous cell, while can be with Induction human body in II phase detoxication enzymes, while suppress I type enzymes generation, eventually through various enzyme bodies with discharge carcinogen and from By oxious components such as bases.Research finds that sulforaphen antitumaous effect mainly produces the generation needed for carcinogenic effect by blocking carcinogen Thank to approach, hinder to carcinogen or other metabolite and enter target cell, while the carcinogenic effect of removing is played, anticancer Division and growth, block circulation approach, promote other kill the protein secreting of cancerous cell, block carcinogen induced cancer Effect.Separately there is research, the important active mechanism of sulforaphen is the hinge of Targeted-control cellular stress signal path, can be notable The expression of itself antioxidase is activated, so as to improve resistance of the human body to chemical damage.Human experimentation result shows, sulforaphen In each tissue of energy significantly human activin, antioxidation and metabolic detoxification mechanism suppress the growth of tumor cell.

It is reported that, Something English scientist research finds that sulforaphen is favorably improved the anti-cancer ability of itself, prevents swollen Tumor cell growth, resistance problems in solution radiotherapy, chemotherapy, according to another report, sulforaphen causes the pylorus spiral shell of gastric cancer with killing Effect of bacillus, and the function of breast carcinoma stem cell can also be killed.

2nd, protect respiratory tract：One recent studies on finds that sulforaphen may help to prevent from exhaling inflammation, so as to reduce asthma, mistake The incidence rate of quick property rhinitis and chronic obstruction lung sexually transmitted disease (STD), it was reported that California, USA university Los Angeles branch school research worker represents, trailing plants Foretelling thionin can stimulate respiratory tract antioxidation preferably to play a role, and prevent contaminated grade for air, pollen, vehicle exhaust and medicated cigarette Jing Respiratory tract is crossed into a large amount of free radicals of human body.These free radicals can damage tissue, and inflammation can be caused to occur.By 65 The name person's of participating in the experiment controlled trial, in the sulforaphen person's of participating in the experiment nasal cavity cell, antioxidase is higher 2-3 times than control.

3rd, contribute to removing Pulmonary bacterial：Research shows, sulforaphen has and helps remove pulmonary noxious bacteria, it was reported that U.S. Johns Huo Jinjinsi university research personnel have found that sulforaphen can activate a kind of signalling channel of entitled NRF2.It is this Signalling channel can not once play a role, and human macrophages cannot just remove the dead cell and alien bacteria of pulmonary, so as to Make pulmonary keep cleaning, cause infection.The macrophage of smoker and chronic obstructive patient all loses this clear Reason function.According to another report, sulforaphen also has antibacterium and antifungal activity.

In addition, sulforaphen has analgesic effect swollen clearly well to arthritis.

In sum, the product nourishing the liver and kidney, YIN nourishing tonifying the lung, benefiting QI and nourishing blood, invigorating the spleen and regulating the stomach, phlegm reduction of blood circulation promoting, hepatoprotective, Hard masses softening and resolving, improve endocrine, strengthening the body resistance, it is aid digestion, increase appetite, calmness of calming the nerves, hypnosis, anxiety, radioprotective, anti-tired Labor, improve constipation, treatment Nausea and vomiting, antiviral, anti-inflammation, cancer-resisting.With immunologic function is strengthened, suppress chemistry Property hepatic injury, function of spleen and stomach regulating function, adjust neuroendocrine, improve sleep quality, mitigate toxic and side effects of chemoradiotherapy and chemicotherapy Damage to histoorgan, repair damaged tissues and recover physical ability, improve patient clinical symptom, reduce postoperative complication, prevent Tumor recurrence with transfer, improve life in patients and delay life cycle, comprehensive nutrient adjuvant therapy of malignant tumor, qi-restoratives and cancer Disease postoperative rehabilitation etc. is acted on.

6th, processing technology：

1st, raw material mixing：Raw material in formula is mixed by physical characteristics.

2nd, stir：Mixed raw material feeding blender is stirred.

3rd, tabletting：The raw material for stirring is sent into into tablet machine, it is tabletted.

4th, test package：By the tablet being pressed into, it is qualified to check, and is packaged as finished product.

Raw material mixed processes are by the process of all raw material mixing in component design.Raw material stirring operation is will be mixed The process that raw material is stirred.Sheeting process is the tabletted process of the raw material that will be stirred, test package work Sequence is that the tablet for suppressing is checked qualified, is packaged as finished product.

7th, quality standard：

1st, physical and chemical index：

2nd, instructions of taking：3 times a day, each serving 2-3 gram of consumption.

3rd, adaptation population：Can not perform the operation suitable for each tumor patient clinic chemicotherapy, postoperative rehabilitation and malignant tumor later stage Patients etc..

Embodiment：Take 10-60 kilogram of Lycium ruthenicum Murr. extract, 20-70 kilogram of Tricholoma matsutake (lto et lmai) Singer (Grifola frondosa) extract, rue sesame extract 30-80 kilogram, 40-90 kilogram of Radix Hedysari extract, 50-100 kilogram of Stichopus japonicuss (Radix Codonopsis) extract, Radix Et Caulis Acanthopanacis Senticosi extract 15-50 thousand Gram, 25-65 kilogram of Herba Dendrobii extract, 35-75 kilogram of Rhizoma Atractylodis Macrocephalae extract, 45-85 kilogram of Semen Ginkgo extract, Bulbus Lilii extract 55-95 kilogram, 10-40 kilogram of Rhizoma Curcumae Longae extract, 20-50 kilogram of Fructus Amomi Rotunduss (Fructus Amomi) extract, Rhizoma Zingiberis Recenss extract 30-60 thousand Gram, 40-70 kilogram of Green tea extract, 50-80 kilogram of spirulina extract, 10-40 kilogram of sulforaphen be raw material.Through will be with Upper raw material mixing, stirs, and feeding tablet machine is tabletted by raw material, and it is qualified to check, and is packaged as finished product.

Claims

1. Lycium ruthenicum Murr. anticancer lifesaving piece processing technology, it is characterized by：10-60 kilogram of Lycium ruthenicum Murr. extract, Tricholoma matsutake (lto et lmai) Singer (Grifola frondosa) extraction Take 20-70 kilogram of thing, 30-80 kilogram of rue sesame extract, 40-90 kilogram of Radix Hedysari extract, Stichopus japonicuss (Radix Codonopsis) extract 50-100 Kilogram, 15-50 kilogram of Radix Et Caulis Acanthopanacis Senticosi extract, 25-65 kilogram of Herba Dendrobii extract, 35-75 kilogram of Rhizoma Atractylodis Macrocephalae extract, Semen Ginkgo extraction Take 45-85 kilogram of thing, 55-95 kilogram of Bulbus Lilii extract, 10-40 kilogram of Rhizoma Curcumae Longae extract, Fructus Amomi Rotunduss (Fructus Amomi) extract 20-50 Kilogram, 30-60 kilogram of Rhizoma Zingiberis Recenss extract, 40-70 kilogram of Green tea extract, 50-80 kilogram of spirulina extract, sulforaphen 10- 40 kilograms is raw material, through above raw material is mixed, is stirred, and feeding tablet machine is tabletted by raw material, inspection It is qualified, it is packaged as finished product.