CN109620858A

CN109620858A - The integration of drinking and medicinal herbs preparation for preventing and treating diabetes

Info

Publication number: CN109620858A
Application number: CN201910136625.3A
Authority: CN
Inventors: 韩合旭
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-02-25
Filing date: 2019-02-25
Publication date: 2019-04-16

Abstract

The present invention provides the integration of drinking and medicinal herbs preparation of prevention and treatment diabetes, safely and effectively reaches adjusting and takes crowd's blood glucose prevention and treatment complication medicine multi-component combination health-oriented products.More particularly to having the natural multi-component composition for improving the complication that blood sugar in diabetic patients is caused by blood glucose, belong to functional medical and health health product and preparation method thereof technical field.It is raw material that the supplementary material prescription of product provided by the invention, which includes: Gynura procumbens (Lour.) Merr, yeast beta-dextran, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum,.It takes product of the invention for a long time, blood glucose can not only be effectively reduced, moreover it is possible to which continuous enhancing autoimmunity resistance improves the generation for avoiding many complication, so as to improve the clinical symptoms of diabetic.

Description

The integration of drinking and medicinal herbs preparation for preventing and treating diabetes

One, technical field:

The present invention relates to one kind to belong to pharmaceutical technology field, has more particularly to the integration of drinking and medicinal herbs preparation of prevention and treatment diabetes Preventing and treating diabetic complication improves the natural multi-component composition of quality of life in patients with diabetes, belongs to functional medical and health and protects Strong product and preparation method thereof technical field.

Two, background technique introduction:

Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye, Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.There is apparent genetic heterogeneity in 1 type or diabetes B.2 Patients with type Ⅰ DM has found a variety of specific gene mutations, as insulin gene, insulin receptor gene, glucokinase gene, Chondriogen etc..Diabetic shows as more drinks, more foods, diuresis and weight loss, the long-term hyperglycemia of diabetic The complication of the multiple tissues of the bodies such as eye, kidney, blood vessel, nerve and heart or organ can also be caused, while diabetic can also There is various acute complication, such as ketoacidosis coerces patient vitals if giving treatment to endanger not in time.

As people's lifestyle changes, diabetic increases year by year, diabetes have become influence mid-aged population Quality of life and a kind of important diseases for threatening mid-aged population life security.There is not radical cure yet for diabetes so far Method, treatment mainly includes blood sugar monitoring, dietary therapy, exercise therapy and oral hypoglycemic agents treatment, according to the morbidity of diabetes Reason and characteristics of incidence, at present oral hypoglycemic agents mainly include and sulfonylurea, non-iodine ureide derivative, biguanides, insulin sensitivity enhancing Agent and alpha-glucosidase restrainer, but during Long-term Oral antidiabetic drug, it is also easy to produce hypoglycemia, while above-mentioned orally-taken blood sugar reducing There are apparent adverse reactions for medicine, can cause patient's gastrointestinal tract discomfort, lactic acidosis etc..Chinese medicine thinks a point upper, middle and lower of quenching one's thirst Disappear, the basic pathogenesis of diabetes is that the deficiency of Yin is scorching, the deficiency of Yin be this, it is scorching for mark, the two reciprocal causation, lesion internal organs be lung, spleen, Kidney three is dirty closely related.Mid-term that early period is fire excess from yin deficiency, which is felt frustrated, there is deficiency of both qi and yin, and advanced stage yin-yang is double to lose.It may occur in which blood stasis in the course of disease Sign；The deficiency of the kidney yin, liver are lost and support, and mesh is without supporting, and it is puckery to can lead to the dry mesh of mesh, blurring of vision, or even blinds；Interior knot is hot and suffocating, can Cause boil, ulcer；The deficiency of Yin is scorching, refines liquid into phlegm, can cause hemiplegia；The deficiency of the kidney yin, yin deficiency affecting yang, spleen kidney yang decline, and water-wet is general Excessively, become oedema；Yin-fluid is extremely consumed, and is caused yin to exhaust sun and is died, and sees unconsciousness, is had dry skin, peripheral coldness, and weak and small pulse is intended to The danger such as exhausted are waited.According to diabetes Chinese medicine characteristics of incidence, currently, people have developed single or herbal mixture to treat glycosuria Disease, but blood sugar decreasing effect is undesirable.

Product of the present invention selects instant medicinal tea and tablet convenient to take as product forms.The main original of product of the present invention Material be Gynura procumbens (Lour.) Merr, yeast beta-dextran, mesona (Chinese mesona herb), show arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum are raw material, It is purified, spray drying, the instant tea that the main techniques such as granulation, packaging are process.Raw material is extracted, granulation, tabletting, divides The tablet composition that the main techniques such as dress, packaging are process is portable to take therapy.

Primary raw material Gynura procumbens (Lour.) Merr (Gynura procumbens (Lour.) Merr.) is composite family Gynura Cass plant. " Chinese medicinal herb compilation " volume two is recorded: its curative effect is slightly sweet flavor, mild-natured, clearing and activating the channels and collaterals, inflammation-diminishing and cough-controlling, eliminating stasis to subdue swelling, promoting blood circulation Myogenic.It is mainly used for treating traumatic injury, rheumatic arthritis and gout.Gynura procumbens (Lour.) Merr has clearing and activating the channels and collaterals, swelling and pain relieving, disappears Scorching cough-relieving, hypoglycemic and other effects are mainly used for treating traumatic injury, rheumatic arthritis, Bronchopneumonia and pulmonary tuberculosis.

In China, in May, 2012 Gynura procumbens (Lour.) Merr is appointed as new resource food by health ministry.Studies have shown that lying down chrysanthemum There are many physiological actions such as hypoglycemic, decompression, lipid-loweringing etc. for Radix Notoginseng.Its main active has chlorogenic acid, flavonoids, alkaloid, terpene Alkenes, Coumarins, volatile oil etc..Mainly edible young stem and leaf has clearing heat and detoxicating, hemostasis cough-relieving, reduces blood vessel purpura, improves Body immunity and anti-virus ability；Purging intense heat, anti-inflammatory, is promoted the production of body fluid and other effects at cool blood, has certain curative effect for swollen disease.

Gynura procumbens (Lour.) Merr is studied through safety evaluatio, and Gynura procumbens (Lour.) Merr is a kind of high-quality special health vegetables of nontoxic grade, Rhizome is Chinese patent drug raw material.Its cook edible or medicinal nutrition and chemical analysis, it is the middle-aged and the old which, which is rich in organic calcium, Optimal green food of replenishing the calcium；Determination of Organic Acids and flavone compound rich in, neochlorogenic acid tool in Determination of Organic Acids Have antiviral well and enhance human immunity effect, to inhibiting hepatitis type B virus to have obvious action, also there is anti-Chinese mugwort Grow the effect of disease virus and influenza virus.Antiviral, anti-flu, improves immunity and other effects, and external application is to shingles zoster, various Dermatitis, scald, burn and nameless gall have good curative effect, can also stop blooding, relieve pain, antipruritic and skin care moisturizing anti-aging.

Primary raw material yeast beta-dextran, yeast (Yeast) are a kind of to live closely related eukaryotic microorganisms with us. China's yeast resource very abundant.The weight of yeast cell wall accounts for the 30% of entire dry cell weight, and wherein beta glucan accounts for 50%.Early in the sixties in last century, scientists have found that zymosan (Zymosan) there is stimulation to make phagocyte With, then by the separation and purifying to zymosan, Riggi in 1961 etc. determined this activity in zymosan at Dividing is beta glucan.Yeast beta-dextran is first and is found to have immunocompetent glucan, has started glucan conduct The new page of immunologic active material research.Yeast beta-dextran because have multiple biological activities more and more attention has been paid to.β-Portugal is poly- Sugar is mainly made of glucans such as β-(1-3), β-(1-4), β-(1-6), is widely present in many bacteriums, fungi and high plant In object.Medical research is it has proven convenient that beta glucan has panimmunity adjustment effect, such as antitumor, antiviral, anti-oxidant, anti-spoke It penetrates, is hypoglycemic, the multiple biological activities such as reducing blood lipid, wherein the most deep to the research of the beta glucan in yeast.Beta glucan It is the main component for constituting yeast cell wall, accounts for the 30%~60% of cell wall dry weight.Since yeast beta-dextran has biology Activity is high, heat is low and the performances such as moisture holding capacity is high, can be wide as function factor, fat substitute and dietary fiber etc. It is general be applied to pharmaceutical developments, animal feeding, be that a kind of functional food of worth research and development is matched in health food industry Nearly more than 50 years of of material grinding in terms of enhancing immunity of organisms, reducing blood lipid and promote about yeast beta-dextran Study carefully very much.

The immune regulation mechanism of bioactivity yeast beta-dextran gos deep into research, and discovery yeast beta-dextran can be with Specificity knot occurs for the immunocyte of animal and the mankind, including unicellular, macrophage, neutrophil leucocyte and natural killer cells It closes.It is intracorporal huge that yeast beta-dextran mainly passes through stimulation animal body endolymph cell, activating animals to the immunocompetence of human body Phagocyte and generate.Lymphocyte is the basic unit for constituting immune organ, is played the role of a nucleus during immune response.Lymph Cell is divided into T, B, NK, K, LAK cell etc., wherein receives the lymphocyte that specific immune response can occur after antigenic stimulus Referred to as Antigen-specific lymphocytes, i.e. T cell and B cell.NK cell, that is, natural killer cells, it is both not required to pierce through antigen Swash, does not also need antibody participation, certain target cells can be killed.NK cell is also a kind of important immunity regulatory cell simultaneously, It has adjustment effect to T cell, B cell, stem cell etc. and is carried out by release cell factor to body's immunity It adjusts.LAK cell is known as the killing cell of cytokine activation, and feature most outstanding is the antitumor action with wide spectrum. MacrophageTens of kinds of receptors can be expressed, tens of kinds of enzymes is generated, and nearly hundred kinds of bioactive products can be secreted, is internal Function one of cell the most active.With phagocytic function, it can actively swallow with eliminating particle exotic antigen or directly kill Sick and wounded pathogenic microorganism；Target cell can also be killed by molecules such as the tumor necrosis factor (TNF-α) of its generation and NO, generated simultaneously Various bioactivators play its immunoregulation effect；Antigen-presenting role be also it as it is a kind of it is immune assist it is thin One of critical function of born of the same parents.Mizuno proposes immune mechanism model of the callose as biological response modifier.Yeast Callose activated T lymphocytes, bone-marrow-derived lymphocyte, NK cell and macrophage.Bone-marrow-derived lymphocyte generates antibody, B cell point Panimmunity function can be performed in the antibody secreted.Antibody can directly neutralize the virose antigen molecule of tool in conjunction with antigen-specific；It is anti- The compound formed after body combination antigen is easily swallowed by phagocyte and is removed；Antibody again can with after antigen binding, in conjunction with benefit Body makes complement activation, kills pathogen.T lymphocyte and macrophages secrete TNF-α, IL and IFN cytokine profiles.Carefully Intracellular cytokine has multifarious biological action, including promotes target cell proliferation, differentiation, enhances resistance to infection, participates in adjusting The immune response and inflammatory reaction for saving body, influence the duration of its response intensity and reaction, influence cell metabolism etc..NK is thin Born of the same parents and active macrophage, which can directly act on target cell, leads to its necrosis.T cell plays a role firstly the need of yeast β-D- Glucan and tumour antigen have an effect to complement macrophage (Complement macrophage), then by cell because Son-interleukin 1 (IL-1) helps T cell (Amplifier helper T cell) generation effect to amplification, On the one hand Amplifier helper Tcell can increase human body by cell factors such as NK, AF and generate NK cell, induce flesh The differentiation of vivo immunization cell acts on B cell under the adjusting of Helper T factor, finally eliminates target cell；Another party Face can also pass through activationEliminate target cell.Pass through cell factor IL-2 and MAF, suppressor T lymphocyte (Suppressor T cell) energy helping B cell activation, moreover it is possible to cytotoxic T cell precursor (Cytotoxic T cellprecursor) is activated, in turn Promote cytotoxic T cell (Cytotoxic T cell) proliferation, under the action of CTL cell factor, releases tumour toxin to body Immunosupress, while the quickly immune supervision of activation body and recognition mechanism, find and distinguish potential tumour cell and direct " phagocytosis " target cell.NK cell passes through its surface Fc γ R in conjunction with the antibody that B cell generates, can be by the cell of antibody-dependant Cytotoxicity (ADCC effect) killing tumor cell of mediation.(LPS, lipopolysaccharides；IL, MAF, helper T factor and CTL is various cell factors).The immune function of yeast beta-dextran has unique triple helix knot due to yeast beta-dextran Structure, and there are immune response mechanism with its recipient cell, therefore have various immune functions.

Anti-tumor activity: Thompson IM's etc. research shows that β-(1 → 3)-glucan, which has, enhances chemotherapeutic effect Fruit.During the mouse for suffering from bladder cancer with treated with cyclophosphamide pulse, addition substantially reduces the death rate after yeast dextran.The U.S. β-(1 → 3)-D- glucan that the Cheung NK in New York etc. is had studied with immunodefiiciency Xenograft Tumor Models, and detect Relationship between its anti-tumor effect and physicochemical property.To the subcutaneous mankind's heteroplastic transplantation model having built up, give daily Beta glucan is oral, is studied by carbohydrate linkage analysis and the analysis of efficient molecular-exclusion chromatography beta glucan, It was found that oral beta-glucan greatly increases the antitumor action that anti-tumor monoclonal antibody (mAb) is established in Mice Body.

Anti-oxidant, promotion wound healing Hakan Kayali etc. is with regard to beta glucan in the experiment of backbone strand tissue damage Prevent oxidation from being studied.Mouse is set to cause injury by the method that weight eminence is fallen, beta glucan is after by wound It is injected into cavum peritoneale, the results showed that yeast beta-dextran, which not only has, cleans internal rubbish effect but also to backbone strand tissue In lipids there is antioxidation, whole body can prevent backbone strand tissue from causing after by wound using beta glucan Secondary damage.Macrophage activity plays an important role on surgery and wound healing.The researchs such as Waisun discovery 20 ~100mg/ml yeast dextran, which is put on the skin, smears animal leg injury, can its significantly accelerated wound healing, using 0.1~0.2mg/ The soluble glucan of kg weight can reduce abdomen thoracic surgery postoperative infection rate.Yeast beta-dextran studies anti-cancer function at present Main target be exactly the activity and phagocytic activity of macrophage for reinforcing being present in high lactation class loading.Beta glucan The ability of macrophage can be enhanced in function.Yeast dextran can improve macrophages phagocytic capacity and reach several times or more, usually have There is the very strong inhibiting rate to mutant, it can further be locked while protecting and enhancing immunocyte fight capability " the residual tumor cell " for determining dormant period, drug resistance and subclinical lesion, carries out targeting antivirus.

Anti-radiation: the quantity that ultraviolet light irradiation will lead to immunocyte in skin is reduced and activity reduces, and cell culture is real It tests and shows that carboxymethyl R-glucan is able to suppress the consumption that ultraviolet light irradiates lower antioxidant molecule, promote the growth of keratan, from And protect Skin Cell.Research shows that class can be completely inhibited by being pre-processed with 0.2% carboxymethyl R-glucan to skin The peroxidization of compound, can be by anti-to the inhibiting effect of lipids reduction caused after ultraviolet light irradiates The topical application of oxidant is observed to obtain.Pathchen ML's etc. research shows that water-soluble dextran can enhance is lured by cobalt -60 Lead radiation quickly recovery from illness.With the mouse of β-(1- > 3)-D- glucan treatment via radiation, the ability of mouse recovery can be enhanced, and Can be improved marrow vigor increases quantity of leucocyte, while enhancing spleens cell number.Prompt anti-radiation, the chemical detoxifying function of neutralization Remove toxin, enhancing immune function.Yeast dextran can stimulate the phagocytosis of the immunocytes such as enhancing NK cell, macrophage living Property, release interleukin is stimulated to enhance the ability that human body resists harmful toxins, can effectively enhance the ability that human body removes toxin, It improves the immunity of the human body；The radiation resistance of glucan is the result for promoting hematopoietic function.The generation activity of haemocyte can be enhanced, The generation of generation, monocyte and organ-tissue cell including granulocyte, to make the spoke because by lethal dose The body cell penetrated and be damaged is restored.

Adjust blood lipid: the special construction of low cholesterol and blood lipid yeast beta-dextran can promote lipoprotein, fatty acid release, Make the lipolytic of macromolecular in blood at small molecule, thus has clarification to serum muddiness caused by hyperlipemia, it can be bright It is aobvious to reduce cholesterolemia.A large amount of zooperies, clinical trial prove that yeast beta-dextran can be effectively reduced Blood Cholesterol Content.Nicolosi etc. studies 15 fat high cholesterol males.Patient remains identical body under study for action Body weight can be substantially reduced 8% of total cholesterol level in blood at the 7th week, drop again within the 8th week on the basis of the 7th week Low 6%.It can be seen that yeast beta-dextran can significantly reduce cholesterol level in blood plasma.Furthermore Z.Kassai etc. the study found that Yeast beta-dextran may be a kind of infiltration inhibitor, and the heavy metals such as caesium, cobalt can be inhibited to enter human body by skin, to eliminate Toxic effect of the heavy metal to human body.The study found that yeast dextran can significantly reduce human body triglyceride level, reduce LDL (low-density lipoprotein) is horizontal, and increases HDL (high-density lipoprotein) level, effectively prevention coronary heart disease, artery sclerosis and The cardiovascular and cerebrovascular diseases such as headstroke.

Prebiotics are defined as a kind of indigestible food ingredients in nineteen ninety-five by prebiotic function Gibson etc., it is this at Divide growth or vigor by selective stimulating one kind or limited several colon bacteriums to be beneficial to host, and then improves place Main health.Snart etc. adds 10% beta glucan discovery, the lactic acid bar in rat colon in rat chow (Lactobacillus) it increases, and demonstrate some Bacillus acidi lacticis by experiment in vitro to utilize the water of beta glucan Solve product DP3, DP4 growth.Avenabeta glucosan oligomer DP1~5 can stimulate L.rhamnosus to some extent, L.plantarum and L.lactis, but L.acidophilus and L.casei are not acted on.In addition, beta glucan can also promote It is proliferated into Bifidobacterium (Bifidobacterium).The rat excrement of fiber group, rye group and oat group is not added with by analyzing The variation of middle microbial flora finds that the quantity of oat group Bacillus acidi lactici and Bifidobacterium both increases.It is sent out in research in vitro Existing, avenabeta glucosan have stimulated B.infantis and B.bidum proliferation.Zhang Yuntao etc. is in research zymosan to chick enteron aisle It is found when microbiota regulating and controlling effect, zymosan is added in its drinking water can reduce in chick enteron aisle greatly significantly The quantity of enterobacteria and salmonella, while have stimulated the proliferation of Bacillus acidi lactici again.It is all pleased equal according to the report, in calf meal Addition yeast beta-dextran can inhibit the quantity of Escherichia coli in early weaning calf enteron aisle, improve the quantity of Bacillus acidi lactici.β- Glucan (β-glucan) is a kind of polysaccharide form being distributed widely in plant, fungi and bacteria cell wall.Past two More than ten years, beta glucan are accepted by people because of the bioactivity of its unique multiplicity.In U.S. Food and Drug Administration (FDA) claim in a Health Claims ratified, the beta glucan in oat and wheat has the function of reducing heart disease risk. Has a large amount of article reviews beta glucan body in terms of reducing cholesterol, control blood glucose, reducing blood pressure, adjust gastrointestinal tract The physiologic function of immune function etc..

When beta glucan enters oral cavity, water swelling is begun to.The expansion of beta glucan is so that food volume increase, stomach Expansion；The water-soluble of beta glucan slows down the increase of food viscosity, gastric emptying speed, and then increases satisfaction when having meal With postprandial satiety.Daou etc. is by having highly viscous Soluble Fiber energy to finding after feeding rats Soluble Fiber Enough reduce gastric emptying rate.Delayed gastric emptying has outside the Pass in addition to the viscosity with beta glucan, also produces with its metabolism in colon Object short chain fatty acids (SCFA) are related.

The enzyme of the decomposition of influence beta glucan to small intestine in the mammalian body cannot hydrolyze beta glucan, therefore, β-Portugal Glycan almost keeps complete molecular weight in small enteral, and then increases the viscosity of entire small intestine contents.Meanwhile beta glucan The viscosity of small intestine contents can be also improved by increasing mucin secretion.The insoluble dietary fiber of many studies have shown thats and Soluble Fiber can promote the secretion of mucoprotein.And this effect has duration.Oat gum is added in rat chow, is held Continuous to feed 15d, after stopping absorbing oat gum 13h, intestinal contents still maintain higher viscosity.As caused by beta glucan Content viscosity, which increases, has the effect that a. hinders the mixing of intestinal lumen contents to the digestion and absorption of nutrient, delays to disappear Change enzyme-to-substrate effect；B. the reduction of mechanical mixture caused by intestinal contraction moves is reduced, and then weakens the emulsification of fat；C. prolong Slow nutrient, which is transported to sorbent surface and the non-stirred thickness degree of sorbent surface, to be increased, and causes Nutrients Absorption to fat digestion and suction The influence in vitro study of receipts shows that soluble dietary fiber increases the size of lipochondrion, reduces the contact surface of fat with water phase, To influence the absorption of fat.Kalra etc. carries out barley beta-glucan feeding rat 40d experiment, and discovery beta glucan reduces The absorption of fat.In the clinical trial for continuing 2 months, the normal young man of blood lipid absorbs 6.9g beta glucan daily, daily Fatty discharge rate increase (6.8 ± 1.1) g from (3.8 ± 1.2) g.Influence to decomposition and the absorption of protein and starch Trypsase, chymotrypsin and alpha-amylase are incubated in vitro together with oat bran, and enzyme activity is reduced to 0.95,0.71 and respectively 0.73, it is incubated with wheat bran, is then reduced to 0.94,0.76 and 0.67 respectively.It is found in patient body in ileostomy, oat Decomposition and absorption of the protein in small intestine are all weakened with barley.Hamberg etc. detects dietary fiber by H2 respiration test To absorbing state discovery of the starch in small intestine, eats unabsorbed content of starch in wheat bran rear intestinal and increased by 4%~17% It is added to 5%~22%, wheat bran weakens the absorption of starch in small intestine.Influence results of animal to small bowel peristalsis shows Dietary fiber including avenabeta glucosan has the function of increasing the intestinal transport time and slows down intestinal absorption.It is clinical real It issues after examination and approval now, on the one hand contractile motion that the high viscosity that water-soluble dietary fiber is formed can neutralize enteron aisle, which causes to wriggle, to be slowed down；But it is another On the one hand stimulation cholecystokinin (CCK) discharges again, and CCK has the function of stimulating small bowel peristalsis.In addition, soluble dietary is fine The SCFA for tieing up formation of fermenting in large intestine can also stimulate intestinal contraction to move.

Influence to large intestine: fermentation and its metabolite SCFA are the main metabolites of enteric microorganism, including acetic acid, Propionic acid and butyric acid etc..It affects the health of host as important anion a kind of in enteron aisle.Casterline etc. is compared The fermentability of 4 kinds of main dietary fiber components including beta glucan, discovery beta glucan have highest production propionic acid With the ability of butyric acid.Water solubility is to influence one of the factor of its fermentability.Wood etc. pass through experiment in vitro it was found that, it is water-soluble Property the fermentability of beta glucan be greater than water-insoluble corn fiber, the fermentability of avenabeta glucosan is greater than wheat β- The tunning total amount of glucan, oat is lower than lactulose, but ingredient is similar.Molecular size range is also to influence its fermentation energy One of factor of power.Immerstrand etc. has found when mouse In vivo study beta glucan molecular weight is with SCFA, different molecular weight The SCFA total amount that the beta glucan of size is generated through enteron aisle microbial fermentation be it is similar, but (propionic acid+butyric acid)/acetic acid ratio with The increase of molecular weight and increase.

Reduce cholesterol, prevent and treat lithiasis: after B yeast dextran enters human body, unique triple-helix structure determines it It will not be hydrolyzed into the monosaccharide such as glucose in gastrointestinal tract and (therefore β -1,3 and 1 is taken to diabetes patient, 6- glucan is without shadow Ring), but combined with specific receptor, by encytosis, eventually pass through enteric epithelium and enter lymphatic system, and from lymph System enters hematological system and plays a role.Cholesterol in liver can be transformed into cholic acid, and arrival small intestine, which can help digest rouge, to be prevented, Then cholic acid can by small intestinal absorption return liver change generating cholesterol again, due to yeast dextran as dietary fiber the energy in small intestine Colloid substance is formed to surround cholic acid,

Cholic acid just cannot be absorbed back liver by intestinal wall, but be excreted by alimentary canal, then work as enteron aisle Interior food carries out digestion when needing cholic acid again, and liver can only supplement the cholic acid of consumption by absorbing the cholesterol in blood, thus Reduce the cholesterol in blood.Beta glucan plays the role of absorbing bile acid and bile acid is promoted to excrete, and promotes cholesterol It is converted to bile acid, the eubolism for maintaining cholesterol intrinsic effectively inhibits the raising of cholesterol in serum, prevents and treats calculi in vivo Disease.

It adjusts blood glucose: improving impression of the distal tissues to insulin, reduce the requirement to insulin, glucose is promoted to restore Normally, there are apparent inhibition and prevention effect to diabetes.Beta Cell of islet can be protected and be repaired to β -1,3/-1,6- glucan, Yeast beta glucan can stimulate related mould substance in spleen, adjust insulin secretion, reach the height of balance blood sugar effect beta glucan Viscosity and gelling property increase barrier of gastric mucosa effect, inhibit glycometabolism.

Smooth away wrinkles, color spot beta glucan is also proved to effectively enhance the induction force of all macrophages in human body, for Lang Gehanshi macrophage in skin has driving effect, can play skin defence and repair function, promote skin corium collagen egg The synthesis capability of bletilla elastic force fibroin, makes wrinkle disappear.The regeneration of bodily tissue structure is helped, rebuilds, repair, wound is promoted to be cured It closes.Clinic confirms that β -1,3/-1,6- glucan can increase skin elasticity, and keep skin tender pale, mention using on the skin The synthesis of high collagen and elastic fibers element supplies various kinds of cell growth factor, eliminates wrinkle, and color spot disappears, and skin is clean Only, and sensitivity phenomenon is repaired.Enhance skin resistance, arouses the self cleaning function of skin " street cleaner ", show healthy skin Beauty.

Main component mesona: Chinese mesona herb (Mesona chinensis Benth.) is Labiatae (Labiatae) Chinese mesona herb Belong to (Mesona Bl.) plant.The herb of Chinese mesona herb system Lamiaceae plant Chinese mesona herb belongs to annual herb perennial plant, and is claimed Freeze for mesona, Mesona chinensis Benth, celestial being, celestial being's dish grass, firewood grass.It is recorded according to " book on Chinese herbal medicine asks former ", Chinese mesona herb has " clear hot summer weather, the mansion Xie Zang knot Heat toxin controls wine wind " the effect of；It is recorded in " south of the Five Ridges gather medicinal herbs record ", Chinese mesona herb can control colored willow poison to the marrow." Chinese medicine dictionary " also has class Like record: mesona sweet-puckery flavor, it is cool in nature.Have the function of clear heat, antipyretic Li Shui, cures mainly heatstroke, heat toxin, quenches one's thirst, hypertension, kidney Disease, diabetes, pain of joint muscle, wine wind, stranguria syndrome etc..What therefore Chinese medicine was common cures mainly children's sore, erysipelas people abdomen, wine wind, height Blood pressure, acute rheumatic arthritis, heatstroke, flu, jaundice, acute nephritis, diabetes etc..Separation and Extraction comes out from Chinese mesona herb Polysaccharide component, proved through pharmacological evaluation, have effects that enhance small white mouse human body immune function, be in small white mouse enteroncus S180 Inhibiting effect, inhibiting rate is up to 60% or so.Above effect is related with active material contained by Chinese mesona herb.In Chinese mesona herb ingredient In, Flavonoid substances have the function of inhibiting growth of cancer cells, reduce blood pressure；Essence be known as it is calm, refrigerant, quench one's thirst, Li Shui Effect；Polysaccharide has enhancing and improves human body immune function effect；Microelement, which has, to be inhibited free radical formation, anti-aging, resists The effect of cancer；Vitamin is adjustable and enhances physiological function etc..The whole world has about 8~10 kinds of Chinese mesona herb platymiscium, is scattered about like the stars and is distributed in Northeastern India is to Southeast Asia and China, each province, southeast wide geographic area.It is widely used among diet civil, Ji Kezuo It is food but also as the special Chinese herbal medicine of medicinal material, there is very high nutrition and pharmaceutical value China to produce 2 kinds, see Taiwan, Zhejiang River, Guangdong, West Guangxi and Western Yunnan.Chinese mesona herb has effects that clear heat, quenches one's thirst, except heat toxin, for treating heatstroke, disappearing Yearningly, hypertension, myalgia, arthralgia.There is phenols component isolated in document report to have antioxidant activity, Cong Zhongfen From obtaining 8 compounds.It is right and by Clonal Rat Pheochromocytoma tumor cloning cell strain (PC12) anti anoxia model experiment Each monomeric compound carries out active testing, and discovery Chinese mesona herb has good Substituted phenyl-lactic acid.Contain polysaccharide, pigment in Chinese mesona herb (predominantly anthocyanidin etc.), ursolic acid, oleanolic acid, α-amyrin, β-amyrin, flavones, pectin and phenols etc., in minerals Iron, calcium, manganese, the content of zinc microelement and potassium are higher, also contain 18 kinds of amino acid and multivitamin, are contained with B family vitamin Measure higher and a small amount of protein, crude fat etc..Studying more important component at present has bean jelly grass polysaccharide, ursolic acid, Qi Dun Tartaric acid etc..Chinese mesona herb extract is rich in polyphenol, flavones, water-soluble polysaccharide isoreactivity ingredient, there is antitumor, resisting cardiovascular disease The effects of disease, anti-aging, anti-oxidant, immunological regulation, hypoglycemic, blood pressure lowering, liver protection.Yang Min is studies have shown that Chinese mesona herb boiling mentions Taking object is a kind of effective exogenous antioxidant, it can be blocked internal by direct or indirect approach scavenging activated oxygen The process of lipid peroxidation maintains the normal physiological function of cell to protect cells from peroxide injury.Hung CY etc. Studies have shown that the antioxidant activity ability of the Chinese mesona herb extract of same amount (0.2g/kg) is than chemical synthesis antioxidant uncle Butylated hydroxy anisole (BHA) and natural vitamin E (VitE) are strong.Yeh CT etc. has studied Chinese mesona herb water extract (WEHT) to the hypotensive activity ingredient of spongtangeous hypertension model rat.6 weeks WEHT of stomach-filling can reduce rat model blood pressure, The malonaldehyde of blood plasma and liver is horizontal and enhances the activities of antioxidant enzymes of liver.Yang M etc. studies Chinese mesona herb extract to diabetes The kidney defencive function of rat model.The result shows that Chinese mesona herb extract can effectively inhibit for diabetic model rats The expression of its pathological variation and thrombospondin.Liu little Ling's etc. studies have shown that Chinese mesona herb has certain liver protection Effect, can be effectively protected the mouse liver injury as caused by carbon tetrachloride (CCl4), and main liver protection substance therein is water-soluble Property substance, and non-prolamine substance.After further study, it is found that the liver-protecting activity group in Chinese mesona herb WEHT is divided into Quercetin-n- O- glucoside and Quercetin-n-O- rhamnoside, substance chemical damage caused by CCl4 have protective effect.Shyu The research of MH etc. has also obtained same conclusion, and Chinese mesona herb extract causes Liver Fibrosis Model rat to have protection to make to by CCl4 With.The studies above the result shows that, Chinese mesona herb extract can be used as the effective efficiency health food for preventing liver fibrosis.According to another report Road, Chinese mesona herb water cooking liquid is in vitro with the active function of direct anti-hepatitis B virus (HBV) in cell culture. Widyaningsih TD uses water, ethyl alcohol, ethyl acetate to extract Chinese mesona herb active constituent respectively, studies it to Hela cell Anticancer activity.Bean jelly grass polysaccharide (M.blume polysaccharides, MBP) is a kind of polysaccharide with gelation, also known as Bean jelly plastic grass (M.blume gum, MBG).MBG content about 26% or so in Chinese mesona herb herb dry sample, Chinese mesona herb is endured with decocting A few hours, filtration take its colloid, suitable starch are added and is cooked again, and the translucent cake shape of dark brown is then formed after to be cooled. It has the function of enhancing and improving human body immune function；Free radical is inhibited to be formed, the effect of anti-aging, anticancer.The report such as Yang Min Road, bean jelly grass polysaccharide significantly inhibit (P < 0.01) to the generation of rat model liver homogenate malonaldehyde caused by H2O2. Flavonoids chemicals have antitumor, resisting cardiovascular disease, anti-aging, anti-oxidant, anti-inflammatory analgesic, immunological regulation, hypoglycemic Etc. a variety of important physiological functions.Chinese mesona herb flavones has OH and 1,1- diphenyl -2- hardship phenylhydrazine free radical (DPPH) Preferable elimination effect is a kind of effective exogenous antioxidant, can by direct or indirect approach scavenging activated oxygen, Block the process of lipid peroxidation.Polyphenol compound has anti-oxidant, reinforcing vascular wall, promotes gastrointestinal disturbances, reduces blood lipid And increase passive protective physical fitness, and prevent the effect of artery sclerosis, thrombosis；Can also diuresis, blood pressure lowering, inhibit bacterium and cancer it is thin It intracellular growth and helps digest.The discovery such as Yen GC is heated 2h to Chinese mesona herb with 0.1%~0.3% sodium carbonate, can be contained There is the extract of more high polyphenolic content and stronger antioxygenic activity；If but concentration of lye > 0.3%, heating time are more than 2h, are extracted The antioxidant activity and Scavenging ability of object all start to be in be decreased obviously trend.Therefore, it is desirable to which it is living to obtain more strong anti-oxidation Property and Scavenging ability, the just notably selection of extracting method.Research it has also been found that, antioxidant activity, to free radical and The Scavenging activity of superoxides has with polyphenol content closely to be contacted.Ursolic acid and oleanolic acid have liver protection, anti-inflammatory, resistance state Reaction, antiviral, antibacterial and antitumor action.It is reported that oleanolic acid remove with liver protection, shield stomach, heart tonifying, anti-arrhythmia, Outside hypoglycemic, reducing blood lipid, antihypertensive bioactivity, also there is anti-inflammatory, antiviral, the immune section that withers, inhibit platelet aggregation With the multiple pharmacological effects such as anti-peroxidation, and toxic side effect is small, highly-safe, there is wide potential applicability in clinical practice.Fatty acid Have effects that reduce blood lipid, softening blood vessel, reduce blood pressure, promote microcirculation, cancer, cardiovascular and cerebrovascular can be effectively prevented and treated Disease, diabetes etc..Amino acid all has important pharmacological action, if glycine is frequently as antiacid and antidote；Glutamic acid Blood ammonia can be reduced, hepatic coma is treated；Asparatate energy kobadrin；Methionine can adjust fat metabolism, and have protection liver The effect of function；Arginine can promote Wound healing, and play the role of adjusting immune function；Cysteine can be relieved in drug Poison；Branched-chain amino acid promotes vivo protein synthesis, highly beneficial to wound and deeline.

It is composite family Inulaplants, perennial herb that primary raw material, which shows arteries and veins Inula britannica chinensis (Inula nervosa Wall.),. It is more raw 1200~2100m of height above sea level under the shaw of low mountainous region, grass slope and wet meadow.Arteries and veins Inula britannica chinensis is shown in Yunnan Popular name is " szechwan-Yunnan sanicle root ", and root hyoscine, mild-natured, mildly bitter flavor is pungent, there is nourishing effects, treats for stomachache and very imitates, and energy degrading the channel, wind-dispelling Dehumidifying, stomach strengthening and digestion promoting, expelling phlegm and arresting coughing." the southern regions of the Yunnan Province book on Chinese herbal medicine " is recorded, this medicine can control cold in chest diaphragm, cold air pain, and appetizing gas can control choke Belch, cold-dampness injury of the tissues bone, tinea pedis, liquor decoct spleen wind of dispelling." Guizhou folk medicine " is recorded, this qi and blood of building up one's health by taking tonic, hidroschesis." in Yunnan Herbal medicine choosing " it records, this medicine wind-damp dispelling, degrading the channel, clearing stagnation and killing pain, treating rheumatic arthritis, pain in waist and lower extremities, stomachache, indigestion, bone Fishbone larynx." choosing of Simao, Yunnan Chinese herbal medicine " is recorded, this medicine Li Shui dehumidifying, relieving cough and reducing sputum, is cured cold, is coughed, high fever.

The root of aobvious arteries and veins Inula britannica chinensis obtains yellowish clear and bright total oil with steam distillation.Through chemical analysis, contain more than 50 ingredients, chrysanthemum The main component of section's Inula is flavones, volatile oil and sequiterpene.Wherein, sequiterpene is the characteristic chemical constituent of this category.Flavones: Luteolin, diosmetin, Kaempferol, patuletin, eupatin, fragrant citrus, 7-O-methylaromadendrine element, Quercetin etc..Times Hemiterpene: alantolactone, Macrophyllilactone E, F, G, 15- deoxygenate sand ground Inulicin, sand ground Inulicin (etc..Volatile oil: nopinene, linalool, Cineole, cumaldehyde, Thymol etc..In addition it is also separated to from Inulaplants The compound of the triterpenes such as oleanolic acid, stigmasterol and steroid.The normal hyoscine of Inula various plants, as elecampane can be used as Stomach invigorating, diuresis, eliminating the phlegm and anthelmintic；Inula Britannica has dissolving phlegm, lower gas, softening hard masses, row water and other effects；Inula britannica cures mainly The diseases such as turgor, extensive abdominal edema under cough dissolving phlegm, rib.In recent years, studies at home and abroad show that, the platymiscium it is antitumor, antiviral, Liver protecting and prevention diabetes etc. all have good bioactivity.Yunnan produces in waterworks design extract containing effective Anticancer component is made into inula flower injection for treating liver, lung cancer.In addition, according to " water southern exposure grass anti-cancer chemical composition selection Research " result of study, by " science of TCM formulas " prescription theory of constitution form prescription compound waterworks design made of Oral solution can be used for treating malignant tumour.Cheng Yonghao has obtained diethyl by performing the derivatization to acetylbritannilactone Acyl Britanin, active testing show that the compound has the very strong activity for killing KB cell and P-388 cell, ED₅₀For 4.6mg/L.Isolated compound tayunin, the active testing from the leaf of I.viscosa such as Maoz M show the change Close object inhibition Microsporum canis, the MIC of Trichophyton rubrum is respectively 10 μ g/mL, 50 μ g/mL.

Song QH etc. tests the activity of Inula britannica using the mouse liver injury model that LPS/PA is induced, as a result table Its bright survival rate that can improve hepatic injury mouse significantly.Kobayashi T etc. is using IFN-γ dependence autoimmune type sugar It urinates disease model and studies Inula britannica Aqueous extracts, the results showed that the mouse that Inula britannica induces streptozocin multiple low dose Autoimmune diabetes have prevention effect.In addition, flavone compound isolated from Inula britannica, such as Wan Shou Chrysanthemum element (patuletin) etc. also has antioxidant activity.Aobvious arteries and veins Inula britannica chinensis is civil for treating rheumatic arthritis, waist-leg Bitterly, the diseases such as stomachache, indigestion, bone sticking larynx show several Phenylpropanoid Glycosides class monomeric compounds in arteries and veins Inula britannica chinensis and have carried out anti-inflammatory activity Study pharmacological evaluation the result shows that monomeric compound XM-6, XM-7, XM-8, XM-9 and XM-10 can press down to a certain extent RAW264.7 macrophage processed generates NO.Anti-inflammatory work of these monomeric compounds to NF- κ B activation inhibiting effect is finally carried out Property screening, the experimental results showed that, tested monomer to NF- κ B activation all do not show apparent inhibiting effect.Pharmacology relievings asthma, dispels Phlegm: oral or aerosol sucks aobvious arteries and veins inula japonica total oil, has apparent protection to make to wheezing to react caused by histamine and acetylcholine With, but curative effect is not so good as isoprel and aminophylline.Aobvious arteries and veins inula japonica total oil, which removes, has stronger relaxation to make tracheal smooth muscle With outer, moreover it is possible to the contraction of the high potassium of antagonism and norepinephrine to rabbit thoracic aorta strips.Anti-inflammatory, antibacterial: the chemistry having is anti- Rotten agent influences the health of people, therefore there is an urgent need to develop safe and non-toxic new type natural preservatives.Thymol belongs to natural production Object has certain bacteriostatic activity, there is good application prospect.Thymol is equal to shigella dysenteriae and various enteritis common bacterias There is stronger antibacterial and bactericidal effect, this is consistent with the result of anti-non-bowel pathogenic bacteria of foreign literature report.Treat odonthemodia Disease Thymol hot iron method can treat dental hyperesthesia.Clinical practice shows Thymol hot iron method safety, without side-effects, to glutinous Film, dental pulp is substantially nonirritant, does not make tooth discoloration, it may also be used for the sensitivity of tooth occurred after abutment preparation goes out after scaling tooth Existing aches.The aobvious arteries and veins Inula britannica chinensis Yi Huo Ministry of Public Health is approved as new resource food within 2012.

Primary raw material jerusalem artichoke (Helianthus tuberosus) be asteraceae helianthus plant, be otherwise known as Jerusalem artichoke or Jerusalem artichoke, synthetism.For pyreticosis, blood under intestines heat, bone fracture and injury is quenched one's thirst." Lisu medicine " nest harrows door: root tuber controls rheumatalgia, intestines Heat rushes down blood, traumatic injury, the diseases such as nasal cavity bleeding from five sense organs or subcutaneous tissue " Nujiang medicine "." anaesthetic " cures mainly febrile disease, the hot hematochezia of intestines, and injury of tendon and muscle fracture " is covered and planted Medicine will ".For heat-clearing drug；Repellent, nature and flavor: sweet in flavor；Slight bitter；It is cool in nature.Effect: clearing heat and cooling blood；Detumescence.The major functions: pyreticosis；Intestines Hot bleeding；Traumatic injury；Fracture swelling and pain, rhizome mash external application and control nameless sores or boils, parotitis.Jerusalem artichoke extracts synanthrin, can treat sugar Urine disease.It has dual regulation to blood glucose, i.e., on the one hand blood sugar in diabetic patients can be made to reduce, and on the other hand can make again low Blood glucose glucose increases.Containing a kind of very approximate with human pancreatic's Li Neisheng insulin structure in studies have shown that Jerusalem artichoke Substance, when urine sugar appears in the urine, edible Jerusalem artichoke can control glucose in urine, and illustrating to have reduces blood glucose effect.When hypoglycemia occurs in people When, it can equally be eased after eating Jerusalem artichoke.In jerusalem artichoke stem tuber contain a large amount of carbohydrate, account for about Fresh Yuxincao 18%~ 20%, levulan content accounts for 80% of carbohydrate or so, also referred to as synanthrin or inulin, is production sugar and bio-ethanol Quality raw materials.Jerusalem artichoke also can not be ignored as a kind of multi-functional plant, medical value.Why jerusalem artichoke has medical value, One of the main reasons is a large amount of synanthrin contained in its stem tuber.Synanthrin has the function of making the Bifidobacterium in enteron aisle to be proliferated, There is certain effect to prevention enteric infection.In addition, synanthrin also has control blood lipid, the harm of cardiovascular disease is reduced, reduces blood Ammonia density promotes the absorption of minerals, anti-to treat constipation and other effects, is suitable for diabetic.Synanthrin can also adjust metabolism function It can, improve lipid-metabolism rate, strengthen immunity and improve mineral absorption conversion.Some researches show that be added synanthrin and make up Product can effectively inhibit the growth of face and skin surface harmful bacteria.Inulin is soluble dietary fiber, in oral cavity, stomach It cannot be digested absorption with small enteral, can only be degraded by the certain beneficial bacteriums of enteron aisle (Bifidobacterium etc.) complete fermentation, generate short chain Fatty acid (acetic acid, propionic acid and butyric acid) and lactic acid generate calorie value and are less than 1.5kcal/g.Jerusalem artichoke ingredient inulin absorbs water under one's belt Expansion forms high viscosity colloid, makes one to be not likely to produce hunger and can extend the emptying time of stomach, so that food intake dose is reduced, Also compound can be formed with substances such as protein, fat in small enteral, inhibit the absorption of substance of this kind, reach weight-reducing purpose.

Blood glucose is adjusted, does not cause blood glucose fluctuation inulin by not decomposing substantially, no during human oral cavity, stomach and small intestine It absorbs, thus will not influence Blood Glucose level and insulin content, and inulin can extend the emptying time of stomach or shorten intestines Haulage time；Gluconeogenesis can be inhibited by generating propionate, reduce plasma free fatty acid level, insulin resistance is promoted to enhance.Drop Blood lipid, prevention cardiovascular and cerebrovascular disease a large number of experiments confirm that inulin can reduce serum total cholesterol and low density lipoprotein cholesterol, High-density lipoprotein/ldl ratio rate is improved, status of blood lipid is improved.The white mouse such as fed with saturated fat is in edible chrysanthemum Lettuce root for a period of time after, content of triglyceride in blood and liver significantly reduces.

Improve function of intestinal canal, prevent constipation and diarrhea inulin can ferment in the colon of people can make Bifidobacterium be proliferated 8~ 10 times, so that harmful bacteria be inhibited to grow.Meanwhile the long-chain polymer contained in inulin is not digested, and can keep moisture in enteron aisle It is not absorbed excessively, increases defecation frequency and quality, to constipation, diarrhea caused by abuse of antibiotics is significantly improved effect. Inhibit harmful tunning, the food remaining residue after digesting and assimilating that prevents colon cancer reaches colon, in enteron aisle spoilage organisms (large intestine Bacillus, clostridium etc.) under the action of can produce many toxic metabolic products, as ammonia (hepatotoxin), nitrosamine are (carcinogenic Object), phenol and cresols (promoting cancer object), secondary bile acid (colon cancer promotion object) etc..Bifid can be dramatically increased after intake inulin The growth of bacillus inhibits spoilage organisms growth, reduces the generation of toxic products, and there is absorption chelating to make toxic tunning With, eliminate corruption product and bacteriotoxin, thus mitigate burden of liver promote nutrition synthesis.In addition the short chain that inulin metabolism generates Fatty acid can reduce intestinal pH, inhibit the growth of spoilage organisms, increase defecation frequency and quality, accelerate carcinogenic excretion, favorably In preventing colon cancer.Pre- anti-cancer effect inulin has potential pre- anti-cancer effect, and effect generates short chain rouge after fermentation Fat acid, especially butyric acid and high concentration calcium and magnesium ion cell proliferation inhibiting effect.It is some the study found that butyric acid is viscous in colon The epithelium Absorption And Metabolism of film, can promote enteric epithelium hyperplasia keeps columnar cell and goblet cell more raw, and goblet cell mucus increases, dimension Colon and full intestinal mucosa integrality are held, makes to damage epithelium DNA reparation, inhibits kinds of tumor cells growth, Cell differentiation inducing activity； Sodium butyrate can also induce cancer cell that apoptosis occurs by many approach simultaneously, have significant antitumaous effect.In addition, inulin can be in intestines It is enriched with calcium and magnesium ion in road, these cation concns is caused to increase, controls cancer cell multiplication rate.

The synthesis inulin of the absorption and vitamin that promote minerals can greatly improve Ca²⁺, Mg²⁺, Zn²⁺, Cu²⁺And Fe²⁺Deng The absorption of minerals, this is because inulin is degraded in fermentation, the short chain fatty acids generated make the pH inside enteron aisle reduce by 1 ~2 units, increase metal ion solubility, and promoting Passive diffusion makes more metal ions enter enterocyte.Synanthrin The short chain fatty acids of decomposition can also stimulate mucous membrane of colon to grow, to increase absorption area.In addition, the metabolite of inulin can promote Into the synthesis of B family vitamin and folic acid, the metabolism of body is improved, improves immunity and premunition.

Primary raw material florists Chrysould likehemum [Dendranthema Morifolium (Ramat) Tzvel.cv.Gongju], is commonly called as " emblem Chrysanthemum " is the excellent Dendranthema morifolium Varieties for taking pains to foster out for a long time by Anhui south medicinal herb grower, is known as " hat in chrysanthemum ".Huangshan Gongju quilt State General Administration for Quality Supervision ratifies the agricultural product for being classified as the protection of place of origin.Dendranthema morifolium sweetness and bitterness, it is slightly cold.Include chrysanthemum glycosides, adenine, Choline and retinol1, B1, amino acid, the ingredients such as potassium, sodium salt, clinical application prove: the calm nervous centralis of energy enhances blood capillary The anti-inflammatory power of pipe inhibits human body tubercle bacillus, staphylococcus, Pseudomonas aeruginosa, influenza virus, dermatophyte, comma bacillus, hammer The activity of bacterium.There is the effect of clearing liver and improving vision, fall fire of getting rid of evils, refrigerant inducing diaphoresis.Chrysanthemum tea to dry, hyperactivity of fire, mesh are puckery effect, heat After drink, panhidrosis feels relief, and is the good medicine for curing flu and health drink suitable for people of all ages.What Huangshan Gongju extracted The antioxygenic property of general flavone can make tea, steep in wine, and Chang Yinke " peace and quiet the five internal organs, toxin-expelling body-building " has the effect of prolonging malicious beauty. Pillow can also be useed as by drinking after used chrysanthemum dries, and make one cool to reduce pathogenic fire, improving eyesight restoring consciouness." Huangshan Gongju " can control cold, The diseases such as furuncle swelling toxin, slight Hypertension and artery sclerosis.The patent medicine such as SUNJU GANMAO PIAN can be made by deploying other medicines with it.Mount Huang Florists Chrysould likehemum flower is always just known as the flower of long life and anti-ageing, wherein decomposition and excretion with aging ingredient and promotion cholesterol Ingredient.Its beauty functions are: sharp qi and blood, profit skin, refresh oneself, " beneficial color " can conserve hair.Early in the Yuan Dynasty's " imperial medicine School " in just have using chrysanthemum as main ingredient be made hair washing chrysanthemum powder forimproving record, cure mainly epilation.The famous physician's Zhang Jingyue of the Ming Dynasty Face also, which is wiped, with medicines such as chrysanthemum, the roots of Dahurain angelica controls freckle, it is quite powerful.The constitution of people and the note promoted longevity can be enhanced as chrysanthemum It carries, just has from ancient times very much.

In conclusion there is this product hypoglycemic activity effect to be used, there are the various features such as safe and nontoxic, green. Hypoglycemic multi-component combination simultaneously, instant tea is convenient to take, and extraction concentration technique is made tablet and delays blood-sugar decreasing active Release and absorption, effectively extend control level of postprandial blood sugar time.Therefore, hypoglycemic healthy group prepared by the present invention Composition powder and instant tea tablets agent energy multipath, portable long-acting control level of postprandial blood sugar.Take safety.

Summary of the invention

Safely and effectively reach adjusting the object of the present invention is to provide one kind and takes crowd's blood glucose medicine multiple groups subassembly Object health-oriented products.There is improvement blood sugar in diabetic patients quality of life more particularly to the integration of drinking and medicinal herbs preparation of prevention and treatment diabetes Natural multi-component composition belongs to functional medical and health health product and preparation method thereof technical field.

The supplementary material prescription of product provided by the invention includes: Gynura procumbens (Lour.) Merr, yeast beta-dextran, mesona (bean jelly Grass), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum be raw material.

Prescription supplementary material weight ratio provided by the invention includes: 100-900 parts of raw material Gynura procumbens (Lour.) Merr, yeast beta-dextran 1-100 parts, 1-100 parts of mesona (Chinese mesona herb), 1-600 parts of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), 1-300 parts of jerusalem artichoke, florists Chrysould likehemum 1-100 Part.

Supplementary material weight ratio according to the present invention is preferred, and corresponding includes 100 parts of raw material Gynura procumbens (Lour.) Merr, yeast beta-dextran 1 part, 1 part of mesona (Chinese mesona herb), 1 part of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), 1 part of jerusalem artichoke, 1 part of florists Chrysould likehemum.

Supplementary material weight ratio according to the present invention is it is also preferred that corresponding poly- comprising 300 parts of raw material Gynura procumbens (Lour.) Merr, yeast β-Portugal 90 parts of sugar, 60 parts of mesona (Chinese mesona herb), 300 parts of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), 80 parts of jerusalem artichoke, 50 parts of florists Chrysould likehemum.

Supplementary material weight ratio according to the present invention is it is also preferred that corresponding poly- comprising 900 parts of raw material Gynura procumbens (Lour.) Merr, yeast β-Portugal 100 parts of sugar, 100 parts of mesona (Chinese mesona herb), 600 parts of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), 300 parts of jerusalem artichoke, 100 parts of florists Chrysould likehemum.

The present invention is specifically by the preparation of following steps

Instant medicinal tea preparation:

The above Gynura procumbens (Lour.) Merr, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum add decocting to purify, water It mentions 3 times, the 1st 3h, the 2nd 2h, the 3rd 1h, collecting decoction, filters, filtrate is concentrated into the clear cream that relative density is 1.40, spray Mist is dry, adds recipe quantity yeast beta-dextran, appropriate corrigent xylitol and appropriate amount of auxiliary materials dextrin, mixes, with 70% ethyl alcohol system Grain, dry, whole grain dispenses up to instant tea.To obtain the final product.

Tablet preparation:

Gynura procumbens (Lour.) Merr, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum, give as one thinks fit cataclasm, add 80% 6 times of ethyl alcohol amounts, in 80 DEG C of dipping 4h, ethyl alcohol is recycled in filtration.Residue adds water to cook 2 times, each 1h, collecting decoction, filtration, with Above-mentioned ethanol extract mixing is condensed into thick paste, adds appropriate amount of starch, yeast beta-dextran, xylitol to mix, pelletizes, dry, mistake Sieve, appropriate magnesium stearate system of adding are made piece, are coated or are not coated.To obtain the final product.

Specific embodiment

Following embodiments are used for the preparation illustrated the present invention, but it cannot constitute any limit to the scope of the present invention System.

Embodiment 1:

For the ease of the application of health and medicine product of the present invention, which is prepared into instant tea and tablet:

Supplementary material medicine proportion: corresponding includes raw material Gynura procumbens (Lour.) Merr 100g, yeast beta-dextran 1g, mesona (Chinese mesona herb) 1g, aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root) 1g, jerusalem artichoke 1g, florists Chrysould likehemum 1g.

Instant method for preparing medicinal tea thereof:

Method for preparing tablet thereof:

Gynura procumbens (Lour.) Merr, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum, give as one thinks fit cataclasm, add 80% 6 times of ethyl alcohol amounts, in 80 DEG C of dipping 4h, ethyl alcohol is recycled in filtration.Residue adds water to cook 2 times, each 1h, collecting decoction, filtration, with Above-mentioned ethanol extract mixing is condensed into thick paste, adds appropriate amount of starch, yeast beta-dextran, xylitol to mix, pelletizes, dry, mistake Sieve, appropriate magnesium stearate system of adding are made piece, coating or be not coated to get.

Embodiment 2:

Supplementary material medicine proportion: corresponding includes raw material Gynura procumbens (Lour.) Merr 300g, yeast beta-dextran 90g, mesona (Chinese mesona herb) 60g, aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root) 300g, jerusalem artichoke 80g, florists Chrysould likehemum 50g.

Instant method for preparing medicinal tea thereof:

Method for preparing tablet thereof:

Embodiment 3:

It is corresponding sheathed comprising raw material Gynura procumbens (Lour.) Merr 900g, yeast beta-dextran 100g, mesona (Chinese mesona herb) 100g, aobvious arteries and veins Flower (szechwan-Yunnan sanicle root) 600g, jerusalem artichoke 300g, florists Chrysould likehemum 100g.

Instant method for preparing medicinal tea thereof:

Method for preparing tablet thereof:

Test example

Have the effect of hypoglycemic to illustrate the present invention, has carried out diabetes by health-oriented products obtained by embodiment method Crowd's test-meal development test example.

Mr. Wang, female, the age 75 years old.Patient suffers from diabetes as long as the several years, in recent years aggravation, face Huang edema, eyesight Fuzzy decline, thirst and liking cold drink, appetite is fine, and limbs are thin thin, and abnormal heat is vexed, pain in the loins leg acid, bipod edema, and moving difficulty is right There is ulcer in five toe end of foot.Detection: fasting blood-glucose 14.8mmol/L, glucose in urine (++++), blood leukocytes 11.9 × 10⁹/ L, in Property 0.78.Diagnosis by feeling the pulse pulse condition moistens weak, lingual diagnosis: graphic tongue, red tongue body, afternoon accidental wagging the tongue.Constipation.Tcm diagnosis: stomach Qi deficiency is simultaneous Diabete (deficiency of Yin is scorching).Doctor trained in Western medicine diagnosis: diabetic keratopathy foot disease.After a week, binocular vision improves oral this product, fasting blood-glucose 7.8mmol/L, thirsty to have solved, dysphoria has been removed, and right crus of diaphragm ulcer is gradually dry to have healing to be inclined to, but still lean and haggard, and the soreness of waist is out of strength, arteries and veins As impractical.This is healthy energy is insufficient, the time of deficiency in both YIN and YANG.Above-mentioned treatment through 3 wheat harvesting periods again, five toe end of patient are almost recovered, Wound healing, both feet action all make moderate progress, and all cards are alleviated.

Zhang, male, 67 years old.Patient is known as diabetic history, and mostly drink gluttony, urine are more.Patient's posture is fat, fever in the afternoon, right The recess that instep redness affected limb swelling is pressed, the sliding number of diagnosis by feeling the pulse pulse condition, there is ecchymosis on white and greasy fur, lingual diagnosis tongue side.Look into fasting blood-glucose 12.9mmol/L, glucose in urine (+++), blood leukocytes 15.1 × 10⁹/ L, neutrophil leucocyte 0.87.Tcm diagnosis: in disappear and under disappear (fire excess from yin deficiency, damp invasion of lower energizer).Doctor trained in Western medicine diagnosis: diabetic complication foot disease oedema.Take the swollen mitigation of 15 days back legs of this product, urine Sugar does not subtract, and blood glucose is reduced to 6.7mmol/L, reduces to take orally and visits Tang Ping and other Western medicine patient main suit qualities of life and body Many symptoms are improved during taking this product.

Zhao, male, 68 years old.Patient had found before 10 years and is diagnosed as " insulin-dependent diabetes mellitus ", used insulin always Blood glucose is controlled, blood glucose, blood lipid, weight are normal, but have polydipsia, and feverishness in palms and soles is numb in every limb, and it is cold, it is gradually double Sufficient edema especially little toe is purple dark and has intermittent claudication.Physical examination: diagnosis by feeling the pulse deep thready pulse is puckery, and lingual diagnosis tongue is dim crackle yellow and greasy fur. Biped skin-color is dark, skin sense is cool, and the non-ulceration surrounding skin of biped little toe is purple dark, and pulsation of foot dorsal artery is weak thin.Fasting blood-glucose 7.6mmol/L, postprandial 2 hours blood glucose 10.6mol/L, lower limb body position test (+).Take the swollen mitigation of 10 days back legs of this product, urine Sugar does not subtract, and situation is good before blood glucose is reduced to 5.6mmol/L, patient main suit's quality of life and coordination of body motion ratio to take medicine, especially It is sports fatigue sense mitigation of walking for a long time, and many symptoms are improved during taking this product, and patient gives product curative effect To there is the wish of long-term use certainly.

The raw materials used definite effect of this product, safety are good；It is suitable for that diabetic takes for a long time.Product selects speed simultaneously Molten tea and Tabules, have it is specious, convenient for taking, feature easy to carry.By being analyzed above it is found that this product is thrown There will be good prospect for sales after entering market.

Claims

1. the present invention provides and a kind of safely and effectively reach adjusting and take crowd's blood glucose medicine multi-component combination health-oriented products.It is special It is not to be related to a kind of day that there is the integration of drinking and medicinal herbs preparation for preventing and treating diabetes prevention and treatment complication to improve quality of life in patients with diabetes Right multi-component combination, the supplementary material prescription of product provided by the invention include: Gynura procumbens (Lour.) Merr, yeast beta-dextran, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum are instant medicinal tea and tablet technology of preparing made of raw material forms.

2. invention according to claim 1, it is characterised in that the object prescription supplementary material weight ratio packet provided by the invention It includes: 100-900 parts of raw material Gynura procumbens (Lour.) Merr, 1-100 parts of yeast beta-dextran, 1-100 parts of mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis 1-600 parts of (szechwan-Yunnan sanicle root), 1-300 parts of jerusalem artichoke, 1-100 parts of florists Chrysould likehemum.

3. invention according to claim 2, it is characterised in that the weight ratio of the raw material are as follows: Gynura procumbens (Lour.) Merr 100 Part, 1 part of yeast beta-dextran, 1 part of mesona (Chinese mesona herb), 1 part of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), 1 part of jerusalem artichoke, 1 part of florists Chrysould likehemum.

4. invention according to claim 2, it is characterised in that the weight ratio of the raw material are as follows: Gynura procumbens (Lour.) Merr 300 Part, 90 parts of yeast beta-dextran, 60 parts of mesona (Chinese mesona herb), 300 parts of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), 80 parts of jerusalem artichoke, florists Chrysould likehemum 50 Part.

5. invention according to claim 2, it is characterised in that the weight ratio of the raw material are as follows: corresponding flat comprising raw material Sleeping 900 parts of chrysanthemum Radix Notoginseng, 100 parts of yeast beta-dextran, 100 parts of mesona (Chinese mesona herb), 600 parts of aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), chrysanthemum 300 parts of taro, 100 parts of florists Chrysould likehemum.

6. the active constituent preparation method of -5 any inventions according to claim 1, it is characterised in that the active constituent The formulation method for preparing be made of following steps:

Instant medicinal tea preparation: the above Gynura procumbens (Lour.) Merr, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum add water Purification is decocted, water mentions 3 times, the 1st 3h, the 2nd 2h, the 3rd 1h, collecting decoction, filtration, and it is 1.40 that filtrate, which is concentrated into relative density, Clear cream, spray drying adds recipe quantity yeast beta-dextran, and appropriate corrigent xylitol and appropriate amount of auxiliary materials dextrin mix, with 70% alcohol granulation, dry, whole grain, dispense up to instant tea to get.

Tablet preparation: Gynura procumbens (Lour.) Merr, mesona (Chinese mesona herb), aobvious arteries and veins Inula britannica chinensis (szechwan-Yunnan sanicle root), jerusalem artichoke, florists Chrysould likehemum are given as one thinks fit cataclasm, are added 80% 6 times of ethyl alcohol amount, in 80 DEG C of dipping 4h, ethyl alcohol is recycled in filtration.Residue adds water to cook 2 times, each 1h, collecting decoction, filter It crosses, is mixed with above-mentioned ethanol extract and be condensed into thick paste, add appropriate amount of starch, yeast beta-dextran, xylitol to mix, pelletize, do Dry, sieving, appropriate magnesium stearate system of adding is made piece, coating or be not coated to get.