CN108404019A - Compound chicory root adjusts the solid articles and preparation method thereof of purine metabolic disturbance - Google Patents

Compound chicory root adjusts the solid articles and preparation method thereof of purine metabolic disturbance Download PDF

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CN108404019A
CN108404019A CN201810392491.7A CN201810392491A CN108404019A CN 108404019 A CN108404019 A CN 108404019A CN 201810392491 A CN201810392491 A CN 201810392491A CN 108404019 A CN108404019 A CN 108404019A
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parts
galangal
hyperuricemia
cape jasmine
root
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姜学林
韩世忠
陈万里
张永春
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The present invention provides the solid articles and preparation method thereof that a kind of compound chicory root adjusts purine metabolic disturbance.It provides a kind of purine metabolic disturbance applied to hyperuricemia crowd and prevents the product of hyperuricemia complication.The present invention puies forward its host agent using natural medicine-food dual purpose plant cichory root, cape jasmine, galangal, essence, is made with sodium citrate scientific matching, is free of any artificial synthetic, is all natural type.Human body purine metabolism can be enhanced after taking, body internal organs adjusting is carried out, be conducive to that the pain of patient, red heat symptom etc. is made to be improved, the function situation between each organ of body is gradually adjusted, adjust impaired organism endocrine.Present invention process is simple, at low cost, is easily obtained active component, is suitable for industrialized production, can be used for being prepared into the purine metabolic disturbance for improving hyperuricemia crowd and prevents food, drug or the health products of hyperuricemia complication.

Description

Compound chicory root adjusts the solid articles and preparation method thereof of purine metabolic disturbance
Technical field
The present invention relates to technical field of food healthcare, specifically a kind of compound chicory root adjusts the solid of purine metabolic disturbance Product and preparation method thereof.
Background technology
In recent years, with the promotion of social standard of living, also huge variation is occurring for the dietary structure of people.People It is growing day by day to high sugar, high protein, the intake of high purine group food, cause body also keeping body dirty while absorbing nutrition Device carries out the operating of high load capacity.Therefore, the incidence of all kinds of metabolic diseases shows the trend risen year by year.
Hyperuricemia (Hyperuricemia, HUA) is one group with heredity and (or) acquired uric acid excretion is caused to subtract Less and (or) internal disorders of purine metabolism, cause a kind of disease that blood uric acid increases [C.Remedios, M.Shah, A.G.Bhasker, et al.Hyperuricemia:A Reality in the Indian Obese [J] .OBES SURG, 2012,22:945-948.].As people's living standard improves and lifestyle change, the incidence of hyperuricemia by Year increases (10% or more), but the early stage of hyperuricemia is asymptomatic, and only blood uric acid duration or fluctuation increase, from blood Uric acid be increased to symptom appearance time be the several years to many decades [in of heap of stone from blood it is turbid opinion control primary asymptomatic height urinate The Jinan clinical research [D] of acidaemia:Shandong Traditional Chinese Medicine University, 2009.]；And most people is to the cognition degree of hyperuricemia Relatively low, lower to diet Rural Residents ' Knowledge about Hypertension [Chen Zhiming, He Xiaoqin health educations are to Patients with Hyperuricemia intervention effect Evaluate the Zhejiang [J] preventive medicine, 2010,22 (10):82-83.], so often getting the brush-off.
Now with living-pattern preservation, the uric acid that body generates increases, in the human body of normal renal function, may pass through The excretion for increasing urine uric acid and the capacity (tissue deposition) for increasing uric acid pond come compensatory.It is compensatory for a long time to lead to renal impairment, Compensatory capacity declines, and the excretion of uric acid is reduced, and the deposition of tissue increases.At this time, it may be necessary to inhibit by the treatment of drug The generation of uric acid or the excretion for promoting uric acid.
Domestic and international massive epidemiology and clinical studies show, hyperuricemia are not only single common metabolic disease Disease, it is close with numerous cardiovascular and cerebrovascular diseases such as hypertension, coronary heart disease, artery sclerosis, heart failure, myocardial infarction and cerebral apoplexy Cut phase is closed, and the human bodies organ-tissue such as kidney, liver, joint can be also involved, even its independent risk factor [the new of Guo Li without Symptom hyperuricemia merges Prespect of Diagnosis of Cardiovascular Diseases and suggests that Chinese Consensus of experts understands the practical internal medicine journal of [J] China, 2011,31 (4):271-273.].Therefore, by the analysis to hyperuricemia harmfulness, general public and medical care are reminded Personnel, it is understood that the necessity of hyperuricemia drug therapy is the task of top priority.
Since limit purine diet can only slightly reduce UA, to the Patients with Hyperuricemia of blood UA high, individually selection limit is fast Purine diet, effect is limited.Therefore, drug [Liu Pingli, Zhang Chengli the asymptomatic hyperuricemias of anti-trioxypurine need to be applied Disease diagnoses and treats in [J]
State's Excerpta Medica clinical practice, 2002,4:27.]:
1. reduce uric acid maintains uric acid crystal saturation point or less (6mg/dL or 360 μm of ol/L), other purine by blood UA levels Alcohol is effective drug for inhibiting uric acid to generate, should be since low dose (100mg/d)；But there is allergic dermatitis, hepatic disorder, Acute hepatocellular necrosis, upper gastrointestinal bleeding, the adverse reactions such as bone marrow suppression are treated asymptomatic hyperuricemia and are not recommended.
2. promoting the available sulfinpyrazone (narcaricin) of uric acid excretion, but renal hypofunction person disables.
3. having tophaceous deposition, and renal hypofunction does not show author, can merge using the above two classes drug, or with " leading to Beneficial wind is peaceful " piece (containing allopurinol and narcaricin).
4. Febuxostat (Feluxostat) [Becker MA, Schumacher HR, Wortmann RL, et al.Febuxostat compared with allopurinol in patients with hyperuricemia and Gout [J] .N Engl J Med, 2005,353 (23):2450-2461.] it is a kind of new xanthine oxidase inhibitor, In European and American countries application, but its company claims that the medicine is not recommended to be used for asymptomatic hyperuricemia.
5. hyperuricemia is associated with hypertension, coronary heart disease, diabetes, urinary tract infections, renal failure etc., except according to etiological treatment Outside, to consider plus use the drug of drop UA；Melbine, Atorvastatin, fenofibrate, Losartan, Amlodipine are in hypoglycemic, tune While fat, decompression, there is different degrees of anti-trioxypurine effect, application may be selected, but should not use long.Therefore, 2 types sugar is being treated On complex disease as urine disease, compared with chemicals, Chinese medicine has unrivaled advantage.
Currently, the asymptomatic hyperuricemia of clinical treatment still lacks safe and effective ideal medicament.
Hyperuricemia finds for biochemical analysis, though it is somebody's turn to do without the record specifically for " hyperuricemia " in traditional Chinese medicine Disease be developed to middle and later periods initiation " gout " belong to the sick scope such as Chinese medical ' arthralgia syndrome ', " joint-running ", " athlete's foot " [Chen LY, Zhu WH, Chen ZW, et al.Relationship between hyperuricemia and metabolic Syndrome [J] .JZUS-B, 2007,8:593-598.- Guo Jing, king lack the dietetic regulation of the asymptomatic hyperuricemias of outstanding person It is debated with Chinese medicine and controls thinking [J] Beijing University of Chinese Medicine journal, 2010,33 (11):786-788.].Chinese medicine always payes attention to disease Prevention, it is proposed that the thought of " sage's preventing diseases instead for the treatment of diseases ".Traditional Chinese medicine has been pushed to new forward position by the transition in epoch, with The change of human habitat, environmental pollution, bad life style and feelings will internal injury have become new pathogenic factor, spectrum of disease Change, a large amount of appearance of silent disese, Chinese medicine by hoping, hear, asking, cutting the needs that the four methods of diagnosis cannot be satisfied clinical diagnosis, The result that doctor trained in Western medicine clinical examination should be intimately associated is diagnosed, and the Chinese traditional treatment to hyperuricemia is actively developed, and plays Chinese medicine Medicine advantage.
Therefore, with the idea of " people is organic whole ", from traditional Chinese and western medicine clinical practice, in conjunction with Developments, fortune With natural medicine-food dual purpose plant, the new approaches of hyperuricemia are prevented from adjusting endocrinal environment angle.According to patient clinical disease Existing difference between shape and constitution is specific to choose the natural medicine-food dual purpose plant progress body internal organs tune for adjusting purine metabolic disturbance Section, is conducive to that the pain of patient, red heat symptom etc. is made to be improved, and gradually adjusts the function situation between each organ of body, moreover it is possible to It is enough obviously to reach the curative effects such as Wen Yang, dredging collateral, help to promote control effect.
Compound chicory root adjusts purine metabolic disturbance solid product：Its using natural medicine-food dual purpose plant cichory root, Cape jasmine, galangal, essence put forward its host agent, are made with sodium citrate scientific matching, are free of any artificial synthetic, are all natural Type.Therefore, the product for studying purine metabolic disturbance is the emphasis that today's society is paid close attention to jointly.In conclusion exploitation integration of drinking and medicinal herbs Natural improvement purine metabolic disturbance product will have extremely wide foreground.
Invention content
The purpose of the present invention is to solve the above-mentioned problems of the prior art, and then provide a kind of compound chicory root tune Save purine metabolic disturbance solid articles and preparation method thereof, act on prevention hyperuricemia crowd purine metabolic disturbance and Prevent hyperuricemia complication.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of compound chicory root adjusts the solid articles of purine metabolic disturbance, based on cichory root, cape jasmine, galangal, extract Raw material is wanted, sodium citrate is equipped with and is mixed, wherein the weight proportion of various raw materials is：9-30 parts of cape jasmine of 9-30 portions of cichory root is high 0.5-3 parts of sodium citrate of 9-30 parts of galingal.
Further, the weight proportion of various raw materials is：9-15 portions of cichory root 9-15 portions of cape jasmine 9-15 portions of lemons of galangal Sour sodium 1-2 parts.
Further, the weight proportion of various raw materials is：15 parts of cichory root, 15 parts of cape jasmine, 15 parts of sodium citrates 2 of galangal Part.
A kind of preparation method of the solid articles of compound chicory root adjusting purine metabolic disturbance,
A, it takes cichory root, cape jasmine, galangal to be pulverized and mixed, is put into water extractor, solution is moisturized within 12 hours with 65 degree of soaking in Chinese liquor It inhales, solid-liquid ratio 1：1.5~2.0 times.
B, distilled water is heated to 100 DEG C, be added in the extractor for being placed with cichory root, cape jasmine, galangal desorption powder, filter carries Secondary, each 5min merges extracting solution, is concentrated into medicinal extract, is dried under reduced pressure, to be ground into 80 mesh powder spare.
C, spare powder is taken, gradient mixing is carried out in right amount with sodium citrate, dextrin, is pelletized, packing obtains solid articles.
The beneficial effects of the invention are as follows：By using technical scheme of the present invention, the natural edible of integration of drinking and medicinal herbs is selected to plant Object is raw material, and each component meets food pharmaceutical control and administration law regulation, and adjusting human body purine metabolism using the comprehensive function of each taste balances, improve by The organism endocrine metabolic disorder of damage.It is non-toxic to humans without chemical addition agent.
Present invention process is simple, at low cost, is easily obtained nutritional ingredient position, is suitable for industrialized production, can be used for making It is standby at human body purine metabolism balance is adjusted, improve answering for the drug of impaired organism endocrine metabolic disorder, food or health products With.
Specific implementation mode
The present invention is described in further detail below：The present embodiment under based on the technical solution of the present invention into Row is implemented, and gives detailed embodiment, but protection scope of the present invention is not limited to following embodiments.
A kind of compound chicory root involved by the present embodiment adjusts the solid articles of purine metabolic disturbance, with cichory root, Cape jasmine Son, galangal, extract are primary raw material, are equipped with sodium citrate and are mixed, wherein the weight proportion of various raw materials is：Witloof 9-30 parts of root 9-30 parts of cape jasmine 0.5-3 parts of sodium citrate of 9-30 parts of galangal.
Preferably, the weight proportion of various raw materials is：9-15 parts of cichory root 9-15 parts of cape jasmine 9-15 parts of citric acids of galangal 1-2 parts of sodium.
Preferably, the weight proportion of various raw materials is：15 parts of cichory root, 15 parts of cape jasmine, 15 parts of galangal, 2 parts of sodium citrate.
A kind of preparation method of the solid articles of compound chicory root adjusting purine metabolic disturbance,
A, it takes cichory root, cape jasmine, galangal to be pulverized and mixed, is put into water extractor, solution is moisturized within 12 hours with 65 degree of soaking in Chinese liquor It inhales, solid-liquid ratio 1：1.5~2.0 times.
B, distilled water is heated to 100 DEG C, be added in the extractor for being placed with cichory root, cape jasmine, galangal desorption powder, filter carries Secondary, each 5min merges extracting solution, is concentrated into medicinal extract, is dried under reduced pressure, to be ground into 80 mesh powder spare.
C, spare powder is taken, gradient mixing is carried out in right amount with sodium citrate, dextrin or soluble starch, is pelletized, packing obtains To solid articles.
One important feature of complex solid product of the present invention is to contain abundant nutritional ingredient position, wherein chrysanthemum in product Chlorogenic acid, aesculin, Cichoric acid contained in lettuce root are good anti-trioxypurine active constituents, and safety is preferable, play medicine The mechanism of effect may be related with XOD, ADA activity is inhibited；Contain Gardenoside and crocins compound in cape jasmine, there is part By inhibiting the activity of xanthine oxidase to reduce serum uric acid level, and there may be other anti-trioxypurine approach；Gao Liang Flavonoids, volatile oil and diaryl heptane substance for containing in ginger etc. have significant xanthine oxidase (XOD) inhibitor Effect.Also there is antiulcer, anti diar rhea, adjust bowel movement, cholagogic, anti-pain, anti-inflammatory, anti anoxia, anti-freezing, antithrombus formation etc. Effect.
Complex solid product nutritional ingredient position of the present invention is through preliminary edible identification：Human body purine metabolism can be enhanced, carried out Body internal organs are adjusted, and are conducive to that the pain of patient, red heat symptom etc. is made to be improved, and gradually adjust the running between each organ of body Situation adjusts impaired organism endocrine, therefore, can be developed into answering for the drug for preventing hyperuricemia, food or health products With.
Hyperuricemia (HUA) refers to the non-empty stomach serum uric acid level male twice on the same day under normal purine diet state Higher than 420 μm ol/L, women are higher than 360 μm of ol/L, i.e. referred to as hyperuricemia.
1. the standard of hyperuricemia
Under normal purine diet state, non-empty stomach serum uric acid level is male twice on the same day>416.5 μm of ol/L or female>357μmol/L.
2. the classification diagnosis of hyperuricemia
Classification diagnosis helps to find the cause of disease of hyperuricemia, gives immunotherapy targeted autoantibody.The low purine drink of Patients with Hyperuricemia Food leaves and takes twenty-four-hour urine detection urine uric acid level after 5 days.
(1) good figure uric acid excretion is not less than 2.86 μm of ol/ (kgh) to uric acid excretion, and uric acid clearance is less than 6.2ml/ min。
(2) uric acid generated many types of uric acid excretion more than 3 μm of ol/ (kgh), and uric acid clearance is greater than or equal to 6.2ml/ min。
(3) mixed type uric acid excretion is more than 3 μm of ol/ (kgkh), and uric acid clearance is less than 6.2ml/min.
Influence in view of renal function to uric acid excretion, is corrected with creatinine clearance rate, is removed according to uric acid clearance/creatinine Rate ratio is as follows to hyperuricemia parting：>10% for uric acid generated it is many types of；<5% is uric acid excretion not good figure；5%~ 10% is mixed type.
Random blood uric acid blood uric acid instrument
Uric acid instrument on the market and blood glucose meter belong to capillary detection.Whether it oneself surveys or arrives hospital, only with capillary Blood vessel detection all cannot be used for diagnosing, and its precision and hospital's venous blood detection also have certain deviation.
When patient's serum uric acid level is higher, the probability that error occurs in the test of uric acid instrument also can accordingly increase, and range up to 200 Left and right, but actually this problem have no effect on uric acid instrument be truly present value --- observation of curative effect and medication monitoring.
Patients with Hyperuricemia takes the variation of uric acid level (umol/l) (after 7 days) before and after product
Before A takes After B takes
780 520
630 530
850 560
650 480
770 392
700 480
630 480
790 390
860 570
740 520
710 495
560 465
540 360
680 605
610 460 1.80229E-07
Result of study illustrates that compound chicory root adjusts purine metabolic disturbance solid articles and can effectively improve human body purine metabolism Adjust disorderly reduction serum uric acid level (P<0.01)；
Compound chicory root adjusts the natural adjusting human body purine metabolism balance that purine metabolic disturbance solid articles are integration of drinking and medicinal herbs, changes It is apt to impaired organism endocrine metabolic disorder, there will be extremely wide foreground.
Cichory root in this product, cape jasmine, the nutritional ingredient of galangal and sodium citrate physiological function：
1. being feverfew saussurea intybus Cichorium glandulosum Boiss.et Hout and witloof Cichorium The root of intybus L. dryings.Autumn excavates, and removes impurity, dries.
Witloof contains moisture (94.18%), soluble solid (4.43%), vitamin C (22.8mg/100g), thick egg (2.02%), 17 kinds of amino acid (1.34g/100g) in vain, zinc (0.310mg/kg), calcium (73.8mg/100g), Organic Selenium Containing fructose (5.247mg), glucose (2.181mg), sucrose in (0.0026mg/100g), every 100 grams of witloof dry matters (0.651mg) and gentianic acid (33.522mg), chlorogenic acid (25.331mg), rutin (17.431mg), caffeic acid (14.700mg), catechin (6.904mg), salicylic acid (6.852mg), epicatechin (6.011mg), vanillic acid (4.396mg), Quercetin (4.345mg), syringic acid (2.267mg) etc..Heat has 71.2 kilojoules.Data show that witloof " long romaine lettuce " is a kind of The very high vegetables of edible value.
Contain aesculetin, aesculin, cichoriin, lactucin, lactucopicin, α-mountain lettuce in witloof Various trace elements such as alcohol, 17 kinds of amino acid, beta carotene, vitamin A, vitamin C and calcium, potassium, sodium, selenium, zinc and prebiotic (prebiotics (Prebiotics) refer to the food composition for being not easy to be digested to member, pass through the stimulation one or more bacterium of selectivity Growth with activity and to host generate wholesome effect, so as to improve the substance of host health.Prebiotics include mainly various Oligosaccharides substance (Oligosaccharides) or oligosaccharide (being made of 2~10 molecule monosaccharide).More generally method is Functional oligose.) etc. ingredient with high nutritive value.So many nutritional ingredient make witloof have be adjusted in synchronism blood fat, Blood glucose, blood uric acid, that is, improve unique pharmacological activity of human endocrine disorder, while can be effectively improved human flora's distribution, adjusts Section functions of intestines and stomach, gut purge defaecation, fall fire are moisturized, slim skin care, are enhanced human immunity, not to cerebrovascular sclerosis, nutrition The diseases such as benign anaemia have certain protective action, and are also the greasy preferred good merchantable brand of meat or fish that relieves the effect of alcohol.
Cichory root contain synanthrin and aromatic substance, promote human digestive organ activity, have clearing heat and detoxicating, inducing diuresis to remove edema, stomach invigorating, Hypoglycemic, lipid-loweringing, anti-trioxypurine and other effects.Multinomial research experiment shows that cichory root has the function of Adjust-blood lipid and anti-trioxypurine, urinates height Sour triacylglycerol mass formed by blood stasis has good adjustment effect, and can obviously improve the hyperuricemia caused by high purine diet and Central obesity.Its mechanism of action may be by reducing liver acyl CoA carboxylase enzyme, fatty acid synthetase and xanthine oxidase Change enzymatic activity, to play the effect of comprehensive adjustment uric acid and abdominal fat accumulation.It is edible and medicinal that cichory root is that one kind has both The special plant of two kinds of functions is classified as " integration of drinking and medicinal herbs class " food by the Ministry of Public Health, while being praised by National Nutrient alliance expert For green " king of health ".There are some researches prove cichory root active principles can significantly reduce uric acid, the blood glucose caused by hyperglycemia It increases, and the effect that the interaction of comprehensive adjustment fat, sugar, uric acid is disorderly.Chicory root extract can obviously improve to be drawn by high purine diet The hyperuricemia and Central obesity of hair, to play the effect of comprehensive adjustment uric acid and abdominal fat accumulation.
For convenience of eating, cichory root has been made into entering our life on behalf of the tea.By cichory root dry shred, frying at Cichory root tea is also blue chrysanthemum root tea, more convenient edible daily, if it is daily maintenence, can 10g is soaked daily drinks, such as Fruit is auxiliary treatment reducing blood lipid, and anti-trioxypurine ensures 10-20g daily.
2. cape jasmine (Garadenia jasminoides), also known as Yellow Fructus Gardeniae, mountain Cape jasmine, Fructus Gardeniae etc., are rubiaceous one kind Evergreen shrubs, main product is in Jiangxi, Zhejiang, Hunan and other places.Cape jasmine fruit system traditional Chinese medicine also falls within first medicine of Ministry of Public Health's promulgation Dual-purpose resource is eaten, has the effects that protect liver, cholagogic, decompression, hemostasis, heat-clearing.Cape jasmine is mainly cape jasmine fruit using part And gardenia, the complex chemical composition of cape jasmine fruit include mainly crocin class, glucoside and polyatomic phenol, additionally contain fruit 20 various trace elements such as glue, mannitol and Fe, Mn, Zn, Cu；Gardenia essential oil containing cape jasmine is the master for refining gardenia compound Want raw material.
The fruit of Chinese medicine cape jasmine has edible value, and taste of tasting is equally sweet just as honey.Chinese medicine cape jasmine fruit There are malic acid and vitamins and other nutritious components in reality, more valuable is also abundant zinc and selenium element.They are high nutritions Substance gives human body basic nutrition supplement.
The dietary function of cape jasmine
There is liver protection effect, hepatic injury caused by chlorination carbon can be mitigated, mitigates the denaturation and necrosis of liver cell.Choleresis can be increased, Promote bile excretion；Stomachial secretion is reduced, gastrointestinal peristalsis is promoted；Also calm, analgesia, anti-inflammatory, antibacterial effect；In addition there is drop blood Pressure reduces myocardial contractive power, makes decreased heart rate, blood vessel dilatation.It is anti-inflammatory.Gardenoside can inhibit inflammation early stage oedema, exudation and inflammation The hyperblastosis in disease late period and granulation tissue generate, and can especially resist brain inflammation.
Antipyretic-antalgic.Gardenoside can effectively inhibit the writhing pain reaction that acetic acid induces, and show analgesic activity；It is apparent to rise The threshold of pain that height stimulates hot plate；There is sedation, can also be obviously prolonged influence of the amobarbital sodium to sleeping time.
Hepatic cholagogic.Gardenoside can effective liver protection, increase bile flow, reduce bile inner cholesterol content, prevent courage solid Alcohol calculus.
Protect nervous system.Gardenoside passes through pro-inflammatory cytokine and blood plasma medium vessels hemogenia after inhibition cerebral ischemia Factor expression plays the protective effect to secondary brain injury.Capejasmine extract geniposide can extend social interaction time, have Antianxiety Activity.Geniposide can protect nerve, and have potential anti-Alzheimer disease to act on.
Protect cardiovascular system.Cape jasmine ethanol extract can treat atherosclerosis.Crocetin can reduce in serum Creatine kinase and lactate dehydrogenase activity, alleviate myocardial stunning, improve myocardial ischemia, prevent myocardial infarction.Cape jasmine Chinese and Western is red Flower glycosides and its metabolin crocetin can inhibit pancreatic lipase activity, significantly reduce serum triacylglycerol, total cholesterol, low density lipoprotein Protein cholesterol and C-VLDL reduce blood fat.Geniposide and its metabolite Geniposide can inhibit phosphorus The activity of resin acid enzyme resists thrombus.
Treatment at present clinically by cape jasmine for gout is also more, and having document report capejasmine extract to have reduces [Zhu Jixiao, Zeng Jinxiang, Luo Guangming wait cape jasmine anti-trioxypurine active components to grind for the effect of the mouse high lithemia of Oteracil Potassium induction Study carefully Chinese experimental pharmacology of traditional Chinese medical formulae magazines, 2012,18 (14): 160~161., Zhu Jixiao, Zhu Yuye, Luo Guangming wait cape jasmines to extract Object reduces chmice acute hyperuricemia serum uric acid level and mechanism study Agriculture of Anhui science, 2011,39 (36): 22317~ 22318,22324.].3. galangal
Galangal nutritional ingredient
Heat 169 kilocalories Thiamine 0 milligram Calcium 75 milligrams
Protein 10.9 grams Riboflavin 0.31 milligram Magnesium 0 milligram
Fat 5.7 gram Niacin 0 milligram Iron 0.5 milligram
Carbohydrate 18.6 grams Vitamin C 0 milligram Manganese 36 milligrams
Dietary fiber 43.3 grams Vitamin E 3.65 milligram Zinc 4.99 milligram
Vitamin A 0 microgram Cholesterol 0 milligram Copper 0.62 milligram
Carotene 8.8 microgram Potassium 87 milligrams Phosphorus 8 milligrams
Retinol 12.7 micrograms Sodium 7.5 milligram Selenium 12.6 micrograms
Galangal nutritional ingredient：Here it is the nutrient content in 100 grams of edible portions in galangal.
Food portion：For the edible portion of every 100 grams of food (inedible part includes skin, seed etc.).
Content：For the nutrient content of 100 grams of food portions (it can be served part).
Galangal trophic analysis：Rhizome contains Galangin (Galangin), kaempferia galanga (Kaempferide) Quercetin (Quercetin) and volatile oil.The main component of oil is 1,8- Cineoles (1,8-Cineole) and cinnamic acid formicester (Methyl cinnamate).The piquancy component of galangal is galangol (Galangol).There is the work of warm taste, cold-dispelling, promoting qi circulation and relieving pain With.
Galangal dietary function：The taste is pungent, warm-natured.Returns spleen, stomach.The peppery temperature of virtue dissipates.Warming spleen and stomach for dispelling cold, regulating qi-flowing for relieving pain.It is main It controls coldness and pain in the epigastrium, vomits hiccup, dysentery, cold hernia, tinea pedis is dysphagic.
Pharmacological action
(1) shows the effect experiment of digestive system：Galangal decoction gives dog gavage, and the total acid output of gastric juice can be made relatively to compare Group is increased significantly, but is had no significant effect to stomach cardia vigor.To intragastric administration on mice, it can significantly fight atropine and inhibit prepared Chinese ink stomach and intestine Propulsion rate, and discharge function caused by folium sennae can be fought, but the discharge function of castor oil cannot be fought.Folium sennae is that stimulation is big Intestines cathartic, and castor oil is stimulation small intestinal cathartic, most drugs for dispelling internal cold are to stimulating big enteral diarrhea to have anti-diarrhea effect.There is report It points out, galangal water decoction has excitation to the movement of isolated rabbit intestinal tube, and low dose can fight hexamethonium and atropine, larger Dosage can inhibit antiadrenergic drug and inderal isolated rabbit jejunum activity, cannot then be fought to diphenhydramine.Prompt galangal Excited intestinal tube activity effect may be unrelated with cholinergic nerve and M- receptors, and may be with it with histamine sample and antiadrenergic drug Sample effect is related.
(2) in vitro, galangal has inhibiting effect to antibacterial actions to Bacillus tuberculosis.Experiment in vitro proves：Gao Liang Ginger decocting liquid (100%) is to bacillus anthracis, alpha-Hemolytic streptococcus, beta hemolytic streptococcus, corynebacterium diphtheriae, bacillus pseudodiphthericus, lung Scorching diplococcus, staphylococcus aureus, Staphylococcus citreus, staphylococcus albus, hay bacillus etc. have different degrees of Antibacterial action.
(3) other effect galangal water extracts of or volatile oil have anti thrombotic action to rat oral gavage；It can make white pottery Native partial thromboplastin time is obviously prolonged, but to plasma prothrombin time, prothrombin time elapsed, thrombin time, V factor, VII factor etc. all have no significant effect, and show that it participates in intrinsic coagulation system, have certain anticoagulation.Water carries Take object that can obviously inhibit ADP or collagen-induced rabbit platelet aggregation.
Galangal decoction can significantly postpone the mouse pain sensation (hot plate method) reaction time.Before its analgesic activity may inhibit with it Row parathyrine synthetase series related with phosphate enzyme system
Galangal ether extract and water extract can significantly extend decapitated mice dehisce duration and potassium cyanide poisoning it is small The time-to-live of mouse；But on the time-to-live of sodium nitrite poisoning mice without influence.Ether extract can extend atmospheric closed anoxic The time-to-live of mouse and slow down body keto consumpting speed；Water extract makees the time-to-live of atmospheric closed hypoxia mice without extension With, but the oxygen Utilization ability of mouse under low oxygen conditions can be improved.
(1) warm in pain acts on：
Galangal water extract and ether extract can significantly stress type ulcer and rat hydrochloric acid ulcer to anti-mouse water logging；Water carries Object has apparent inhibition, two kinds of extracts that can significantly fight diarrhea caused by castor oil, water extract mouse GI tract propulsion It is also effective to diarrhea caused by folium sennae.Water extract has collaboration transaminase raising effect.Two kinds of extracts have anesthetized rat Apparent choleretic effect, ether extract effect are stronger.In thermoae method and acetic acid writhing test, two kinds of extracts have apparent analgesia to make With.
(2) to the influence of microcirculation：Galangal is the warm pain class Chinese medicine of fragrance, has quickly alleviating pain effect to angina pectoris, to slight Arteriole blood flow caused by adrenaline is set to stop or slow down have retardation function.There is retardation function to caliber contraction time.Right So that caliber is had restitution (control group continues to shrink) after ten minutes to adrenaline, also arteriole light contraction is acted on.
(3) to the influence of anoxic and the mouse that catches cold：It can extend decapitated mice to intragastric administration on mice galangal ether extract and water extract It dehisces time-to-live of duration and KCN poisoning mices, but does not influence NaNO2The poisoning mice time-to-live.Ether extract The time-to-live of atmospheric closed hypoxia mice can also be extended and slow down body keto consumpting speed, water extract does not extend atmospheric closed and lacks The time-to-live of oxygen mouse, but the oxygen Utilization ability of mouse under low oxygen conditions can be improved.Two kinds of extracts are to the mouse that catches cold Time-to-live is without influence.
In addition, Galangin, can reduce the serum Uric Acid Concentration of hyperuricemia mouse, mechanism of action may be by pressing down Xanthine oxidase activity processed reduces uric acid and generates.
Galangal is the dry rhizome of zingiberaceous plant galangal, mainly contains flavonoids, volatile oil and diaryl heptane class Close object.Have been reported that display, galangal also has the effect of significant xanthine oxidase (XOD) inhibitor, and XOD is catalysis human body Purine substance is metabolized to the key enzyme of uric acid, inhibits its activity that can reduce internal uric acid concentration, and treatment hyperuricemia [is worn The screening of xanthine oxidase inhibitor and the Wuhan preparation research [D] in vertical treasure's Chinese herbal medicines：Wuhan Engineering Univ, 2010], [QuanH, KaQ, FengZ.Hyperuricemia induces endothelial dysfunc~tion via MitochondrialNa+/Ca2+exchanger-mediated mitochondrial calcium overload [J] .Cell Calcium, 2012,51 (50)：402~410].
4. sodium citrate
Sodium citrate can be used as a kind of food additives, can make foodstuff flavouring, keep food more nice, in good taste, lemon Sour sodium itself also has certain nutritional ingredient, is added to the nutrition that can increase food in food, and sodium citrate is national permission The food additives used.
Sodium citrate is a kind of organic compound after all, is a kind of sodium salt, and many people's worries have been eaten can be harmful, In fact not so, sodium citrate is a kind of substance of alkalinity, and it can be that human body is in a normal ph with balanced human's acid-base value often to eat It is worth range, also alkalinity is very good to the fatigue after alleviating human motion.Sodium citrate is edible.With following excellent Benign energy：
(1) safe and non-toxic performance.Due to preparing the raw material basic source of sodium citrate in grain, thus it is reliable to be perfectly safe, right Human health not will produce harm.The United Nations grain farmer takes the photograph it with the World Health Organization people's amount and is not intended to be limited in any daily, can recognize Belong to No Poison for the product.
(2) there is biological degradability.Sodium citrate partly becomes citric acid, the two after a large amount of water dilution of nature It coexists in same system.Citric acid is in water through oxygen, heat, light, bacterium and the effect of microorganism, it is easy to biology drop occur Solution.It is usually to be changed into carbon dioxide and water through aconitic acid, itaconic acid, Ning Kang Suan Yu that it, which decomposes approach,.
(3) there is complexing of metal ion ability.Sodium citrate has good complexing energy to metal ions such as Ca2+, Mg2+ Power also has good complexing power to other metal ions, such as Fe2+ plasmas.
(4) fabulous solubility property, and dissolubility increases with water temperature and is increased.
(5) there is good pH adjustings and cushion performance.Sodium citrate is a kind of weak acid strong alkali salt, can with compatibility of citric acid Stronger pH buffer is formed, therefore has its important use in certain occasions for being not suitable for pH wide variations.In addition, citric acid When sodium is injected as first salt, for correcting blood, body fluid and the acidity of urine, as diuretics, resolving sputum agent etc..
The active component that the preparation method of the present invention is prepared defines, purity is high.Except edible white in entire preparation method Outside wine, other organic solvents are not used, it is environment friendly and pollution-free.Entire production process is easily achieved the big production of industrialization.
In vitro, internal pharmacodynamics test and preliminary clinical test show by Gao Liang made from preparation method of the present invention Ginger active component has apparent anti-trioxypurine effect.There is good effect for hyperuricemia or patient with gout.
The foregoing is only a preferred embodiment of the present invention, these specific implementation modes are all based on the present invention Different realization methods under general idea, and scope of protection of the present invention is not limited thereto, it is any to be familiar with the art Technical staff in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in, should all cover the present invention Within protection domain.Therefore, the scope of protection of the invention shall be subject to the scope of protection specified in the patent claim.

Claims (4)

1. a kind of compound chicory root adjusts the solid articles of purine metabolic disturbance, it is with cichory root, cape jasmine, galangal, extract Primary raw material is equipped with sodium citrate and is mixed, wherein the weight proportion of various raw materials is：9-30 parts of cape jasmine 9-30 of cichory root Part 0.5-3 parts of sodium citrate of 9-30 parts of galangal.
2. compound chicory root according to claim 1 adjusts the solid articles of purine metabolic disturbance, the weight of various raw materials Proportioning is：9-15 parts of cichory root 9-15 parts of cape jasmine 1-2 parts of sodium citrate of 9-15 parts of galangal.
3. compound chicory root according to claim 2 adjusts the solid articles of purine metabolic disturbance, the weight of various raw materials Proportioning is：15 parts of cichory root, 15 parts of cape jasmine, 15 parts of galangal, 2 parts of sodium citrate.
4. compound chicory root adjusts the preparation method of the solid articles of purine metabolic disturbance,
A, it takes cichory root, cape jasmine, galangal to be pulverized and mixed, is put into water extractor, solution is moisturized within 12 hours with 65 degree of soaking in Chinese liquor It inhales, solid-liquid ratio 1：1.5~2.0 times；
B, distilled water is heated to 100 DEG C, be added in the extractor for being placed with cichory root, cape jasmine, galangal desorption powder, filter carries two Secondary, each 5min merges extracting solution, is concentrated into medicinal extract, is dried under reduced pressure, to be ground into 80 mesh powder spare；
C, spare powder is taken, gradient mixing is carried out in right amount with sodium citrate, dextrin, is pelletized, packing obtains solid articles.
CN201810392491.7A 2018-04-27 2018-04-27 Compound chicory root adjusts the solid articles and preparation method thereof of purine metabolic disturbance Pending CN108404019A (en)

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CN109511984A (en) * 2019-01-09 2019-03-26 丁强 A kind of special dietary seafood with the alleviation gout that celery seed, potassium citrate etc. are primary raw material preparation
CN110051002A (en) * 2019-04-28 2019-07-26 杭州泽健医药科技有限公司 A kind of pharmaceutical composition with anti-trioxypurine effect
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CN113425812A (en) * 2021-08-06 2021-09-24 江苏菇神生物科技有限公司 Compounding method and device of spartina alterniflora extract, chicory and gardenia jasminoides ellis

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