CN104839847A - Nutritious healthcare Radix codonopsis syrup and preparation method thereof - Google Patents

Abstract

The invention discloses nutritious healthcare Radix codonopsis syrup. The nutritious healthcare Radix codonopsis syrup is prepared mainly by using the following two groups of raw material ingredients: A. 60 to 120 percent of Radix codonopsis by weight; B. 2800 to 5600 percent of potable water by weight. The nutritious healthcare Radix codonopsis syrup disclosed by the invention contains various amino acids, microelements and vitamins which cannot be synthesized by human bodies and must be supplied by food, and the pharmacological nutrient substances thereof have the effects of resisting dementia, calming nerves, improving sleeping, resisting eclampsia, improving physiological functions, improving hematopoietic functions, resisting stress, strengthening heart, resisting shocks, regulating blood pressure, resisting myocardial ischemia, defibrillating, reducing viscosity, dissolving embolus, inhibiting platelet aggregation, increasing coronary flow, resisting oxidation, resisting oxygen deficiency and resisting ulcers, and the nutritious healthcare Radix codonopsis syrup is suitable for drinking by people at all ages who suffer from easiness in catching a cold and a cough, weakness in bodies and four limbs, reduced appetite, spleen and lung qi deficiency, chronic anemia, leukemia, spiritlessness, qi and blood deficiencies, sallow complexion, weakness in bodies after illness and delivery, chronic nephritis, proteinuria, neurasthenia and sub-health.

Description

A kind of nutrition and health care Radix Codonopsis dew and preparation method thereof

Technical field

The present invention relates to beverage product field, especially a kind of nutrition and health care Radix Codonopsis dew and preparation method thereof.

Background technology

Vegetables in current people's life, grain, meat, egg, milk, water etc., by the severe contamination of atmospheric environment and the impact of multiple residuals, bring serious harm, the food additives that many food sectors are used to the health of people, as trans-fatty acid high-fructose corn syrup food coloring redness 40, yellow 5, yellow 6, acesulfame-K, hydrogenated vegetable oil, Aspartame and asccharin, natrium nitrosum, Flour ingredient---potassium bromate, monosodium glutamate, these materials added in food such as this formyl of peroxidating, can say it is long-term edible or excessive drinking, can cause cardiovascular and cerebrovascular disease before 30 years, diabetes, cancer, etc. many diseases, but present most of crowd is in sub-health state, once immunity of organism declines, no matter its content height is exactly an immeasurable hidden danger to these potential hazardous substances in cell tissue, the ubiquitous physical and mental health disturbing people of factor of health risk in food sectors widely, moment threatens quality of life and even the life of people, only have scientific and reasonable active prevention effectively could reduce the factor of unfavorable health to self-inflicted disaster, as lulu in the health products beverage that existing market is sold, almond milk, walnut Lu, precious lulu etc., although they have obtained the accreditation of consumer, but they can not meet the healthy needs of care eventually, do not reach the object of complete disease resistance, and a kind of nutrition and health care Radix Codonopsis of the present invention dew have good preventive effect and health-care effect for the various diseases such as inferior health of modern.

Summary of the invention

The technical problem to be solved in the present invention to provide a kind of nutrition and health care " Radix Codonopsis dew " and preparation method thereof, and for solving the problems of the technologies described above, the technical solution used in the present invention is as follows

A kind of health nutrient " Radix Codonopsis dew " its make primarily of following two groups of material compositions

A Radix Codonopsis 60-120% (weight)

B drinking water 2800-5600% (weight)

As a preferred technical solution of the present invention, it is made up of following two groups of material compositions

A Radix Codonopsis 80% (weight)

B drinking water 2100% (weight)

As a preferred technical solution of the present invention, it is made up of following two groups of material compositions

A Radix Codonopsis 40% (weight)

B drinking water 2450% (weight)

The preparation method of upper art nutrition and health care Radix Codonopsis dew, its step comprises: the method comprises the steps:

Radix Codonopsis is cleaned cut into serving pieces by A

B get B group drinking water together with the Radix Codonopsis in A together put into precooker heat boil boil 20 minutes after enter colloid mill and carry out lappingout, reach granularity extremely trickle, again A and B two good for lappingout is formed and point enter homogenizer and carry out homogeneous, after entering filter, enter the infusion of infusion tank enter filling tank after 40 minutes and first tank sterilization is carried out hot filling carrying out more than 90 DEG C temperature, adopt continuous high-temperature disinfection equipment to carry out high temperature sterilization cooling after capping, dry up, coding both finished product.

Nutrition and health care Radix Codonopsis dew of the present invention is made up of a herb Radix Codonopsis and water, and without any additive, dew look pure, and sweet perfume (or spice) is good to eat.Its pharmacology nutrition with invigorating the spleen benefit lung, promote the production of body fluid, benefiting qi and nourishing blood, intelligence promoting and tranquilization, growth promotion, improve cellular energy metabolism, scavenging free radicals, the purity that purifies the blood, adjustment body imbalance state, strengthen and moisten foster function, make qi and blood more vigorous, "Nei Jing" cloud, healthy tendency is deposited interior heresy and can not be done, play the light of its pharmacology trophism by the health that the traditional Chinese medicine that this taste is ancient is modern humans, benefit drinking for a long time of people.

Radix Codonopsis effect:

[property of medicine] sweet puts down, return spleen, lung channel [effect] beneficial gas, promote the production of body fluid, nourish blood

Application:

1, weakness of the spleen and the stomach, gas in sweet flat, the tonifying spleen nourishing the stomach of this product, strong fortune, inspiring clear sun, is the product of conventional tonifying middle-Jiao and Qi

2, the deficiency syndrome of the lung being breathed with cough, being entered lung and not hot-tempered, kind replenishing and restoring lung qi, with controlling insufficiency of lung-QI,deficiency of lung-QI, the low fright due to decicincy of qi of sound, syndrome characterized by dyspnea easily

3, Tianjin wound is thirsty, and this product is sweet flat, bowl spares state, sending up the lucid YANG, beneficial lung qi, cloth body fluid, has the merit of tonifying QI to produce body fluid, for fever caused by exogenous pathogenic factors heat impairing qi Tianjin, restlessness and thirst

4, weak, the beneficial taste of the deficiency of blood, the merit changing precise and tiny, raw cloudy blood, have qi-supplementing, blood-engendering, to swoon palpitaition, the weak disease such as weak with controlling two sallow complexion, the heart lost of qi and blood

[medicine opinion]

1, " new compilation of materia medica " main tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness, middle gas faint in order to adjust mend very smooth and proper

2, " book on Chinese herbal medicine justice " Radix Codonopsis power energy tonifying spleen nourishing the stomach, moistening lung are promoted the production of body fluid, are good for gas in fortune, and this and ginseng are far away very mutually, its outstanding valuable person, then strengthening the spleen and stomach and not dry, grows stomach-Yin and does not wet, moistening lung and do not violate cold and cool, nourish blood and partially do not grow greasy, inspiring clear sun, gas in vibration and without just dry fraud.

Nutritive value: Radix Codonopsis containing the necessary amino acid of polysaccharide, phenols, sterol, volatile oil, vitamin B1, B2 many kinds of human bodies, baicalein, glycoside, saponin and Alkaloid, trace element etc.

Wherein containing glycoside, terpene, carbohydrate, sterols, flavonoids, Ingredients Such As Coumarin, containing 14 kinds of inorganic elements and 17 seed amino acids such as organic acid, vanillic acid, 2-furancarboxylic acid, nicotinic acid and codopiloic acid, iron content, manganese, zinc, selenium, copper, wherein must amino acid containing 7 kinds of human bodies such as aspartic acid, threonine, serine, lysine, a word used in person's names propylhomoserin, isoleucine, glutamic acid.

Sugar and glycoside have: the heteroglycan of synanthrin, fructose, four kinds of fructose, Syringin, B-D-glucopyranose alcohol glucoside, a-D-fructofuranose, ethanol glucoside, glycoside, polysaccharide tangshenoside.

Sterols has a-spinasterol, stigmasterol, a-spinasterol ,-B-D glycoside, stigmasterol-B-D-glycoside, a-spinach sterone etc.

Triterpenes has: the sour fat of alnulin, alnulin, suberone, Radix Codonopsis lactones, 5-hydroxymethylfurfural, 5-methoxyl group alditol.

Coumarins has: root of Dahurain angelica lactones, psoralen and butanedioic acid and rhizoma atractylodis lactones.

Volatile ingredient has: acid, enanthic acid, sad, n-nonanoic acid, dodecoic acid, azelaic acid, tetradecylic acid, pentadecanoic acid, hexadecylic acid, stearic acid, octadecadienoic acid, nonadienoic acid, n-pentadecane, a-curcumene, n-heptadecane, n-octadecane, NSC 77136, just 21 alkane, just docosane, methyl myristate, pentadecanoic acid methyl esters, methyl palmitate, methyl stearate, octadecadienoic acid methyl esters, firpene, ethyl palmitate, methyl caprylate.

Nutrition and health care Radix Codonopsis dew of the present invention has the excellent results of following aspect.

One, helicobacter pylori disease is killed

It is one of the highest bacterium of infection rate in the world that helicobacter pylori (HP) infects, be the paathogenic factor of chronic gastritis and duodenal ulcer be the arch-criminal and the arch-criminal that cause chronic gastropathy, HP is decided to be 1 class procarcinogen by the World Health Organization, in China, population HP infection rate is relatively high, usually the stomachus pyloricus of human body is resided in, the arch-criminal causing disease of stomach, and helicobacter pylori not only parasitic crime on gastric mucosa, also can at oral cavity endoparasitism, particularly in tooth bacterium class, content is maximum, the practice of each person having an individual portion of food do not accomplished by dining table, oral instructions are broadcast and living condition, indirect orofecal is the important risk factor that HP infects, nineteen nineties helicobacter pylori be just listed in a class carcinogen.Helicobacter pylori at the infection rate of global general population more than 50%, the population almost not having a kind of chronic infectious disease that the whole world can be made to exceed half is in the world infected, China's average rate is 55%, confirm that in helicobacter pylori and enterogastric diseases, 4 kinds of diseases are closely-related at present, (1) chronic gastritis, (2) peptic ulcer, (3) cancer of the stomach, (4) gastric mucosa associated lymphoid tissue (MALA) Asia property lymthoma, HP colonizes in mucosa tissue, the gastric ulcer of 67%-80% and the duodenal ulcer of 95% are caused by helicobacter pylori, its harm is not only this, it also can cause gastritis sufferer's obstinate, as chronic gastritis, the bringing out and recur of gastric ulcer, current antibacterials cure rate is lower and easily produce drug resistance, injecting pathway medication is to its nothing effect, per os local is again because the barrier of gastric acid environment mucus amount and the continuous emptying of stomach make drug effect greatly be restricted.American scientist current research finds, too much take in the many again evidences of viewpoint that salt diet is harmful to health in diet, helicobacter pylori disease is a kind of spirality, and micro-anaerobism requires very harsh bacterium to growth conditions.Nineteen eighty-three is separated successfully first from the Mucosa Biopsy tissue of Patients with Chronic Gastritis, it is the current known only microbe species can survived in people's stomach, helicobacter pylori disease comprises the gastritis caused by Helicobacter pylori infection, digestive tract ulcer lymphocytic hyperplasia gastric lymphomas etc., the poor prognosis of helicobacter pylori disease is cancer of the stomach.Clinically to think, chronic gastritis, gastroduodenal ulcer and even cancer of the stomach 80% be that helicobacter pylori causes, PRELIMINARY RESULTS display majority be childhood both by Helicobacter pylori infection, China's resident HP infection rate is up to 60%-70%.Allow nearly tens00000000 common people all use antibiotic therapy, probably manpower and materials all have not good, and the precedent also not having the whole people to treat in the world can be followed.Find that the height of children's Helicobacter pylori infection to Adolescents increases and can produce harmful effect to investigate.Research object is 554 students of 7 years old, result of study find 7-14 year this 7 year, the growth ratio of student's height of helicobacter pylori infections does not have the infected on average to subtract 1.1 centimetres (0.3-2.0 centimetre), especially in the schoolgirl be infected, height increases and obviously slows down, decreased average 1.6 centimetres, Radix Codonopsis is to hydrochloric acid in gastric juice, the inhibitory action of the stomach cardia mucosa injury factor is one of Radix Codonopsis antiulcer action mechanism, experiment shows: Radix Codonopsis decoction 10g/kg duodenal administration can make pylorus-ligated rats gastric secretion total acid output N2 discharge rate reduce for 6 hours, the n-butanol extract of Radix Codonopsis has obvious inhibitory action to rat basal gastric acid secretion, the neutral extract of Radix Codonopsis n-butanol all has significantly prevention and protective effect to stress in rats type pyloric ligation ulcers indocin type and aspirin Experimental Gastric Ucler, the neutral extract water-soluble portion of Radix Codonopsis n-butanol is effective separator that anti-rat stomach glues damage, Radix Codonopsis position VII is the active component of the anti-gastric mucosa injure of Radix Codonopsis, Radix Codonopsis extractive part VII-II is oral can significantly improve normal rat Weibining tablet content, 12 fat enteral administrations can significantly improve pylorus-ligated rats Weibining tablet content, oral administration within 3 hours, obviously can lower rat pipe film injury caused by absolute ethyl alcohol and gastric mucosa precancerosis declines, UI is reduced and gastric mucosa precancerosis reduction after operation, percentage declines, PGE2 content in normal rat gastric tissue can be significantly improved.Its water alcohol precipitation 20g/kg 12 fat enteral administration not only can significantly suppress rat basal gastric acid secretion, also make the stomachial secretion activity that pilocarpinum histamine and pentagastrin cause, gastric secretion, total acid output and pepsin activity all significantly decline, and obviously can suppress the increase of histamine content reduction and serotonin in stress rats gastric tissue, Radix Codonopsis water decoction-alcohol sedimentation liquid is to stress type, and caused by pyloric ligation ulcers indocin or aspirin, Experimental Gastric Ucler all has preventive and therapeutic action.

Codonopsis pilosula polysaccharide 500mg/kg significantly can reduce gastric juice to rat oral gavage; gastric acid secretion and pepsin activity; Codonopsis pilosula polysaccharide is to rat oral gavage 250mg/kg; 500mg/kg is to stress all have obvious anti-ulcer effect by type, indocin type, acetic acid type and pyloric ligation ulcers 4 kinds of rat gastric ulcer models; Codonopsis pilosula polysaccharide also can make gastric mucosa of rat PGE2 content improve; the anti-gastric mucosa injure effect of Radix Codonopsis and the cytoprotection increasing mucous membrane are described, strengthen Gastric mucosa barrier function.

Radix Codonopsis water decoction has antagonism absolute ethyl alcohol, strong acid and highly basic and the rat pipe film injury caused by indocin and the inhibiting rate of gastric ulcer to absolute ethyl alcohol to reach 93.44%.

Radix Codonopsis is the key medicine of beneficial gas in society, can correct the gastrointestinal motility dysfunction of pathological state.

Radix Codonopsis antiulcer action mechanism, (1) gastric acid secretion inhibiting, reduce gastric acidity, (2) secretion of gastric mucus is promoted, strengthen gastric mucus---bicarbonate barrier, (3) endogenous prostaglandin (PGEZ) content gastric mucosa being had to protective effect is increased, the life condition of helicobacter pylori is destroyed by the above mechanism of action, thus reach suppress and prevention helicobacter pylori object and solve modern and prevent cardiovascular and cerebrovascular disease to be used for the injury that dilute blood brings stomach because of long-term taking aspirin, play a role for solving whole people's antiulcer.

Proof test: very serious when I suffers from serious gastritis and then develop into gastric ulcer panic attacks, treat through hospital doctor, the antibiotic having taken a lot of domestic and imported almost can't see curative effect, after use Radix Codonopsis instead and decoct soup, eat soup and take medicine, take and within three months, do gastrocopy ulcer area all healed till now because Radix Codonopsis has multiple effect, use always, stomach trouble never recurred, and all other indexs are all very normal, learnt that the people suffering from gastric ulcer also allows them decoct soup and eats soup to take medicine and obtain good effect.

Two, antitumor action

Codonopsis pilosula polysaccharide has pharmacological action widely, show as immunological regulation antitumor, antiviral etc. for clinical supplemental treatment and the rehabilitation of tumour hepatitis angiocardiopathy, research confirms, Radix Codonopsis has anti-oxidant, the multiple pharmacology biologically active such as resisting stress and immunity moderation function, Codonopsis pilosula polysaccharide is formed by connecting by sugar, the polymer of the degree of polymerization more than more than 10 is a kind of composition in plant cell wall and cell.Polysaccharide has unique biologically active, and play the effect of killing tumour cell, Tumor suppression growth by activating body active immunity, Radix Codonopsis can improve the IV-2 level of mouse, and strengthen immunologic function, Radix Codonopsis decoction also has obvious enhancing to use to the generation of IV-2.Codonopsis pilosula polysaccharide can to have equally the lymphocyte that concanavalin A stimulates the facilitation of normal spleen lymphocyte proliferation and significantly promotes proliferation function, the activate the phagocytic capacity of Radix Codonopsis decocting liquid to macrophage has obvious humidification, and infer it is the basis that immunity of organism strengthens, Radix Codonopsis extract can strengthen Turnover of Mouse Peritoneal Macrophages and engulfs the ability of chicken red blood cell and promote the effect of mononuclear phagocyte system phagocytic function, Codonopsis pilosula polysaccharide can improve the immunologic function of killing and wounding increased activity body of NK cell thus reach antineoplastic object, Codonopsis pilosula polysaccharide has stronger facilitation to humoral immunity, and have facilitation when low dose of administration to cellular immunity, significantly improve immunocompetent cell, strengthening cellular immune function stimulates lymphopoiesis Radix Codonopsis can significantly improve auxiliary type T lymphocyte level and to a certain degree improve an auxiliary type lymphocyte (suppressing/kill and wound type T lymphocyte) ratio, illustrate that Radix Codonopsis decocting liquid low concentration can promote the lymphocytic mitosis of in vitro culture, and the mouse spleen lymphocyte DNA of short con-A activity synthesizes, containing 5 kinds of furocoumarin constituents, there is obvious antitumor activity and the inhibited proliferation to tumour cell in Radix Codonopsis.

Three, body's immunity is improved

Radix Codonopsis obviously can strengthen the phagocytic activity of Turnover of Mouse Peritoneal Macrophages, every day gives every mouse gavaging Radix Codonopsis decoction 0.25g, be used in conjunction 1-2 week, quiet note Iization plasma protein colloidal solid part in blood can be made to clean up speed obviously accelerate, show that the cytophagy of monokaryon one mononuclear phagocyte system strengthens and do mouse peritoneal intramuscular and intravenous injection (respectively by 0.2m '/h, 0.1m '/h and 0.2m ' with asiabell preparation

/ h) after 7 days, the quantity of macrophage obviously increases, cell volume increases, pseudopodium increases, phagocytic activity strengthens, intracellular DNA, RNA, carbohydrate, ACP, enzyme, ATP enzyme, AcE and SDA all significantly strengthen, to mouse peritoneal injection Radix Codonopsis alcohol hypostasis 30g (crude drug)/kg body weight.Obviously can strengthen the phagocytic activity of macrophages being hydrogenated cortisone and suppressing.Dosage is down to the effect of 3g/kg body weight still clearly, obviously can promote its lymphocytic conversion to the immunosuppressed mice that endoxan causes, and strengthens the function of antibody produced cell, improves serum antibody titer level.

Four, cardiovascular disease is prevented

Radix Codonopsis has enhancing myocardial contractive power, increase the antishock effect of cardiac output, Radix Codonopsis parenteral solution is inputted to anesthetized cat vein with the extract of Radix Codonopsis, angiosthenia can be made to go up, survival time of animals extends, Radix Codonopsis liquid has the effect strengthening left ventricular function to coronary heart disease with qi deficiency and blood stasis patient, the oral Radix Codonopsis liquid of patients with coronary artery disease obviously can increase Assessment of Left Ventricular Systolic Function in 1 week, increase cardiac output, on heart rate without impact, Radix Codonopsis obviously can increase the content of mouse cardiac muscle glycogen succinate dehydrogenase and lactic dehydrogenase, and there is anti-normobaric hypoxia histocyte anoxic, the effect of microcirculation anoxic, regulate blood pressure, Radix Codonopsis medicinal extract, alcohol extract, water extract all can make anesthetized rat and rabbits blood pressure significantly decline, injecting Radix Codonopsis parenteral solution to anesthetized dog and rabbit vein can cause of short duration blood pressure to reduce, but repeat administration does not produce tachyphylaxis, the hypotensive effect of Radix Codonopsis also can make the arterial pressure of hemorrhagic shock in rabbits in late period go up mainly due to expanding Radix Codonopsis caused by peripheral vascular, therefore have dual regulation to blood pressure.Resist myocardial ischemia, the intravenous injection of Radix Codonopsis parenteral solution can resist the Acute Myocardial Ischemia in Rats that pituitrin causes.Also there is protective effect in Radix Codonopsis water extracting alcohol hypostasis gastric infusion or Radix Codonopsis parenteral solution injection abdominal cavity to the myocardial ischemia that isoprel causes, ligation dog heart coronary artery rushes left front Zhi Zaocheng acute ischemia, Radix Codonopsis water decoction-alcohol sedimentation liquid significantly can reduce the myocardial ischemia dog LV Diastolic absolute value that last voltage rise is high eventually, prompting Radix Codonopsis improves the diastolic function of cardiac muscle preferably, increase the compliance of cardiac muscle, coronary perfusion drag reduction is made to be conducive to the supply of blood flow of myocardium of left ventricle, thus improve myocardial ischemia, the Platelet Aggregation in Rabbits that Radix Codonopsis liquid can suppress ADP to induce, rabbit vein injection Radix Codonopsis parenteral solution, obviously can reduce WBV and the dynamic degree of blood plasma ratio, suppress inside and outside thrombosis.And the low-density lipoprotein of Hyperlipidemia Rabbits serum can be reduced, the content of triglycerides and cholesterol, Radix Codonopsis water extract-alcohol precipitation liquid can reduce whole blood rat viscosity, ether extract can improve rat annulus proteolytic enzymatic activity, remarkable reduction platelet aggregation rate and the horizontal total saposins of plasma thromboxane TXB2 can significantly reduce TXB2 content and not affect the synthesis of prostacyclin PGI2, Cardiac Muscle of Rats cell is acted on the Radix Codonopsis extract of variable concentrations, result shows that PDE activity is subject to suppression in various degree, CAMP hydrolysis reduces content and increases, increase CaM maximum inhibition with drug concentration after acting on rabbit platelet to increase, 20 routine Treating Patients of Angina Pectoris, take Radix Codonopsis extract after 14 days, significantly improve Pressure Drop between left room E diastole peak value and left chamber poor, significantly shorten the cardiac output that the left room diastole early filling time obviously increases Left ventricular systolic function, but heart rate is without change, Mouse Cardiac Muscle glycogen can be significantly improved through zoopery Radix Codonopsis, the content of succinate dehydrogenase, it is active that Radix Codonopsis can improve ischemia/reperfusion injury cardiac muscle hepatocuprein (SOD), reduce MDA (MDA) content, reduce the release of creatine kinase, the contraction of cardiac muscle and diastolic function are obtained obviously improve, and can cardiac output be promoted, coronary flow, the recovery of stroke output and heart rate, certain maintenance effect is had to Myocardial Lipid Peroxidation damage, thus improve cardiac function.

Five, hypoglycemic activity

Experimental result shows: 1, Codonopsis pilosula polysaccharide has no significant effect normal mouse blood sugar.

2, Codonopsis pilosula polysaccharide raises adrenaline mouse blood sugar obvious inhibitory action, and declining to Mouse Liver glycogen content has significant rising effect, PIt0.05 or PIt0.01.

3, Codonopsis pilosula polysaccharide significantly can reduce blood sugar rising liver glycogen content and the serum insulin level PIt0.05 or PIt0.01 that alloxan causes diabetic mice, significantly can reduce diabetic mice serum TC, TG level, PIt0.05 or PIt0.01 improves the activity of SOD in serum, reduces MDA and produces PIt0.05 or PIt0.01.

4, Codonopsis pilosula polysaccharide significantly can suppress mouse gluconeogenesis PIt0.05 or PIt0.01.

5, Codonopsis pilosula polysaccharide is significantly improved effect PIt0.05 or PIt0.01 to the mouse islets element opposing that hydrocortisone sodium succinate is induced.Result prompting Radix Codonopsis significantly can reduce blood glucose in diabetic mice, regulates diabetic mice blood lipid metabolism, suppresses gluconeogenesis, promote glyconeogenesis, improve insulin resistance.

The many grain of Radix Codonopsis can raise liver glycogen content; serum insulin level; hepatocuprein (SOD) activity improves insulin sensitivity; reduce MDA content, serum total cholesterol (TC), triglyceride (TG) content; the removing being beneficial to free radical slows down peroxidatic reaction of lipid; Radix Codonopsis suppresses the damage of radical pair β cell by improving body anti-oxidation function, protection β cell, thus reduces the blood sugar of diabetic mice.

Six, nootropic effect

The little memory acquisition disturbance that the n-butyl alcohol extract energy antagonism hyoscine of Radix Codonopsis ethanol extract causes, improve mouse memory that natrium nitrosum causes and consolidate the mouse memory reproducing defective that obstacle and 40% ethanol causes, this extract does not affect the synthesis of acetylcholine, may with strengthen acetylcholine and M-acceptor in conjunction with relevant, alkaloids of Dangshen then can resist the decline of acetyl choline content and choline acetylase activity in mouse brain that hyoscine causes, the normal subjects observing all ages and classes by double-blind study can improve ability of learning and memory after taking Radix Codonopsis decocting, and the ability of learning and memory of normal subjects's brain left and right sides hemisphere may be made to improve simultaneously.

Seven, radiation resistance

Hypodermic injection Radix Codonopsis parenteral solution, the high-temperature resistance of mouse can be made to significantly improve, the parenteral solution that Radix Codonopsis decocting liquid and water extraction and alcohol precipitation method obtain can significantly improve the ability of mouse normobaric hypoxia, the time-to-live of obvious prolongation cyanide and natrium nitrosum poisoning mice, there is obvious antagonism to the brain stagnant anoxia caused by the total artery ligation in mouse both sides.Radix Codonopsis can make animal oxygen demand reduce, and can improve brain to the tolerance of ischemic or the oxygen demand reducing brain tissue.Radix Codonopsis methanolic extract, 50% ethanol pellet, water decoction n-butyl alcohol extract etc. can improve the survival rate of small white mouse under anoxia condition, and extend the time-to-live, improve the tolerance of mouse hypobaric hypoxia to agent 0.2ml before the Radix Codonopsis water of every mouse stomach 100%, administration 3 times, can improve 600 rads (being about median lethal dose) ⁶⁰dEG C.Radiation exposure, when irradiating latter 15 minutes, administration group has than control group plasma corticosterone content and obviously increases, and irradiation 4 hours, within 24 hours, then has obvious reduction, illustrates that Radix Codonopsis has excitement and regulating action to pituitary-adrenocortical system.This may be mechanism radiation injury being had to protective effect.

Eight, antifatigue effect

Its effect is better than ginseng, and the experiment of rats'swimming time shows that contrasting ginseng group with physiological saline group extends 38%.

Radix Codonopsis group extends 79%, experimentation observes its mobility of rat awarding Radix Codonopsis group, the appetite state of mind is obviously better than control group, confirm the strong shape effect of the nourishing of Radix Codonopsis, exhausted mining areas is caused with D-galactolipin, Codonopsis pilosula polysaccharide 50 or 150mg/kg-1 simultaneously, d-1 Codonopsis pilosula polysaccharide makes exhausted mining areas Thymus and Spleen index raise, in serum and hepatic tissue, MDA obviously declines and SOD vigor obviously rises, in brain group, LE obviously declines, in nephridial tissue, GSH-PX vigor and NOS vigor obviously raise, silkworm is fed with 20% party's decocting immersion bubble mulberry leaf, the larval phase of silkworm can be extended, full life cycle also puts on weight, agent 0.25 gram before mouse gavaging Radix Codonopsis, its swimming with a load attached to the body ability can be significantly improved.

Radix Codonopsis bowl spares state, sending up the lucid YANG, beneficial taste, the effect changing precise and tiny, raw cloudy blood, have tonifying Qi, green blood.

Taste are barn organs, the foundation of acquired constitution, source of generating QI and blood, and Radix Codonopsis can improve muscle glycogen and hepatic glycogen content.

The liver being the dominator of relaxation and contraction of tendons; Radix Codonopsis qi-supplementing, blood-engendering; body anti anoxia can be improved and improve microcirculation ability; there is excitor nerve; suppress to protective factors in body to adapt to needs effect that body produces stress reaction in heat stress, to reach the object improving body aerobic exercise and antifatigue heat-resisting ability.

Radix Codonopsis anti-aging effects

1, scavenging free radicals antioxidation

Old and feeble free radical theory is proposed by American scholar Hamann the earliest, and it is thought and causes the main cause of mankind aging to be that the process of cellular metabolism is by the free radical constantly produced.Oxygen radical too much can destroy cell membrane and other important component, makes protein and enzyme denaturation, and the damage accumulation caused when free radical defeats the repair ability of body, causes the change of Cell Differentiation state, even loses thus causes and accelerate aging.

Radix Codonopsis and active ingredient thereof have scavenging free radicals antioxidation.Radix Codonopsis extract can significantly improve the activity of superoxide dismutase (SOD) in D-galactolipin Aging mice serum, the active activity that also can improve the sweet peptide of paddy (GSH) of remarkable reduction MDA (MDA): it is active that each concentration group of Radix Codonopsis water extract can significantly improve SOD in D-galactolipin institute Aging mice brain tissue, suppress the peroxidatic reaction of lipid of free radical, reduce the content of lipid-metabolism product MDA, Radix Codonopsis and parenteral solution thereof can raise the expression of SOD and GSH peroxidase (GSH-PZ), prompting Radix Codonopsis can resist oxygen free radical injury, belong to strong anti-oxidation medicine and play an important role in aging course, Codonopsis pilosula polysaccharide can resist the degeneration of senile organism immune organ, remove hydroxyl radical free radical and the cloudy sub and anti peroxidation of lipid of super oxygen in various degree simultaneously, to rat its hypothalamus growth hormone release inhibiting hormone (SOM) neuronal cell number during feeding Radix Codonopsis to 10 monthly age from 3 monthly ages, cell space gray scale and area are all apparently higher than normal group of the same age.Reflect and give Radix Codonopsis person between twenty and fifty and have stronger promotion SOM neuronal development to delay the effect of hypothalamus retrogression.Therefore Radix Codonopsis can alleviate central lesion, delays brain aging.Experiment shows that wall regeneration appears in D galactolipin modeling Mice brain tissues, tissues following MCAO in rats form aspect controlled by the typical old and feeble pathology Radix Codonopsis such as glial cells hyperplasia all improvement in various degree, Radix Codonopsis and active ingredient thereof can play anti-aging effects by multipath, adapt with the universally recognized several causes of senescence of modern medicine, Radix Codonopsis has to be affected spleen and promotes erythropoietic effect, cell health, physique is just healthy, thus reaches anti-aging effects.

Nine, the effect of tracheitis is prevented

Radix Codonopsis can improve Respiratory Distress Syndrom Induced by Oleic Acid rat artery blood oxygen pressure and blood oxygen saturation, reduces CO ₂the effect of dividing potential drop; and rat disturbance of acid-base balance can be corrected, maintain lung and effectively take the photograph oxygen function, rat alveolar epithelial cells and capillary endothelial cell can be protected; make gas normal by the disperse of ABB, for tang-shen treatment Respiratory Distress Syndrome(RDS) provides theoretical foundation.Radix Codonopsis Aqueous extracts has significant antitussive effect to mouse experiment cough, its effect is strong with Dose enhancement factors, the crystallization V1 of Radix Codonopsis also has obvious antitussive effect, Radix changii Aqueous extracts and crystallization V1 all can increase the phenol red discharge rate of Respiratory Tract of Mice and promote frog ciliary movement, show that both all have phlegm-dispelling functions, cause Experimental Asthma In Guinea-pigs to have significant inhibitory action to acetylcholine and histamine, show that it can to antihistamine, the bronchoconstriction that the Anaphylactic mediators such as acetylcholine cause.

Detailed description of the invention

Embodiment 1

A nutrition and health care Radix Codonopsis dew, it is made up of following two groups of material compositions:

A, Radix Codonopsis 80% (weight); B, drinking water 2100% (weight)

Preparation method

A, A group high-quality Radix Codonopsis is cleaned cut into serving pieces

B, get B group drink water together with the Radix Codonopsis in A together put into precooker heat boil boil 20 minutes after enter colloid mill and carry out lappingout, reach granularity extremely trickle A and B two good for lappingout is formed point to enter again after entering metre filter, enter the infusion of infusion tank after homogenizer carries out homogeneous and enter filling tank after 40 minutes, first tank sterilization is being carried out after more than 90 DEG C temperature carry out hot filling capping, is adopting continuous high-temperature disinfection equipment to carry out high temperature sterilization, cools, dries up, coding both finished product.

Proof test, I am due to having deep love for traditional Chinese medicine and pharmacy, liking of unique pharmacology nutritional labeling is had especially to this taste Chinese medicine of Radix Codonopsis, and in conjunction with the modern pharmacological research of Radix Codonopsis, gastric ulcer is prevented and treated for many years with Radix Codonopsis, cardiovascular and cerebrovascular diseases, diabetes, phychasthnia, virus flu year after year, chronic bronchitis, highs fat of blood etc. all serve good effect, long-term edible Radix Codonopsis energy illness prevention and fitness, develop immunitypty, anticancer, increase hemoglobin, Promote cell's growth, delaying cell aging, hypotensive, high temperature resistant, the functions such as radioresistance are all the trophisms that the pharmaceutical component of Radix Codonopsis plays.

Embodiment 2

A nutrition and health care Radix Codonopsis dew, it is made up of following two groups of material compositions:

A, Radix Codonopsis 40% (weight); B, drinking water 2450% (weight)

Preparation method is with embodiment 1

Embodiment 3

A nutrition and health care Radix Codonopsis dew, it is made up of following two groups of material compositions:

A, Radix Codonopsis 200% (weight); B, drinking water 3180% (weight)

Preparation method is with embodiment 1

More than describe and only propose, not as the single restrictive condition to its technical scheme itself as the enforceable technical scheme of the present invention.

Claims (6)

1. a health care Radix Codonopsis dew, is characterized in that: it is made primarily of following two groups of raw materials:

A, Radix Codonopsis 60%-120% (weight); B, drinking water 2800%-5600% (weight).

2. nutrition and health care Radix Codonopsis dew according to claim 1, it is characterized in that, it is made up of following two groups of material compositions:

A, Radix Codonopsis 80% (weight); B, drinking water 2100% (weight).

3. nutrition and health care Radix Codonopsis dew according to claim 1, it is characterized in that, it is made up of following two groups of material compositions:

A, Radix Codonopsis 40% (weight); B, drinking water 2450% (weight).

4. nutrition and health care Radix Codonopsis dew according to claim 1, it is characterized in that, it is made up of following two groups of material compositions:

A, Radix Codonopsis 200% (weight); B, drinking water 3180% (weight).

5. the preparation method of the nutrition and health care Radix Codonopsis dew according to any one of claim 1-4, it is characterized in that, the method comprises the steps:

A, A group Radix Codonopsis is cleaned cut into serving pieces; B, get B group drink water together with the Radix Codonopsis in A group together put into precooker heat 100 DEG C boil boil 20 minutes after enter colloid mill and carry out lappingout defibrination to reach granularity extremely trickle, again A and B two good for lappingout is formed and point to enter homogenizer and carry out homogeneous and after entering metre filter, enter the infusion of infusion tank enter filling tank after 40 minutes, first carry out hot filling by after tank sterilization through more than 90 DEG C temperature, adopt continuous high-temperature disinfection equipment to carry out high temperature sterilization after capping, cool, dry up, coding, finished product.

6. the preparation method of the nutrition and health care Radix Codonopsis dew according to any one of claim 1-4, it is characterized in that comprising and grind slurry with stone mill, method is as follows: get B group drink water and enter precooker in the lump together with the Radix Codonopsis in A group and heat to boil to boil and within 60 minutes, put into stone mill and grind, after defibrination → homogeneous → filtration → sterilization → through more than 90 DEG C high-temperature hot filling → capping → obtain finished product in high temperature sterilization → cool → dry up → coding.