KR102192573B1 - Composition for preventing and improving menstrual pain and skin troubles - Google Patents

Abstract

The present invention relates to a composition containing Beta vulgaris, Cinnamomum cassia, Salvia miltiorrhiza, Paeonia lactiflora, Wolfiporia extensa, and Carthamus tinctorius, and a pharmaceutical composition and a functional food composition containing the same. The composition mixes not only Beta vulgaris having an effect of expanding blood vessels by producing nitrogen monoxide (NO) in the body, but also herbal medicines such as Salvia miltiorrhiza, Cinnamomum cassia, Carthamus tinctorius, etc., which release extravasated blood and promote blood circulation in a specific blending ratio, thereby being able to relieve menstrual pain and alleviate skin troubles in an individual to whom the composition of the present invention is administered. Furthermore, as the composition of the present invention is administered, it is possible to confirm complex effects that the average temperature of the lower abdomen of women is significantly increased, the aggregation of menstrual blood is reduced, the color is brightened, and the inflammation level in the body decreases.

Description

Composition for preventing and improving menstrual pain and skin troubles {COMPOSITION FOR PREVENTING AND IMPROVING MENSTRUAL PAIN AND SKIN TROUBLES}

The present invention relates to a composition for relieving menstrual pain and skin troubles including red beet, gyeji, dansam, peony, bokryeong, and safflower, and a functional food composition comprising the same, and in more detail, it has the effect of releasing blood stagnation and promoting blood circulation. It is characterized in that it is possible to relieve menstrual pain and alleviate skin problems of an individual to whom the composition of the present invention is administered by mixing the possessed natural product at a unique blending ratio.

Menstrual pain refers to lower abdominal pain or low back pain that appears mildly or severely during or before and after menstruation in women of childbearing age. This may result in bloating, diarrhea, and constipation. Menstrual pain is one of the most common gynecological diseases that occur in about 50% of women of childbearing potential. It is usually experienced by young women. It usually occurs within 1 to 2 years after menarche, but severe cases can last up to 40s. Of these, about 10% complain of pain enough to be unable to do what they normally do for 1-3 days each month.

As a result of a survey conducted by Kyung Hee Medical Center's Oriental Medicine Hospital, 47% of women complained of pain such as abdominal pain, low back pain and even headache during menstruation, 13% of gastrointestinal disorders such as anorexia and indigestion, and 8% of women with discomfort.

In particular, among 632 middle and high school girls, 70% complained of menstrual pain and 50% complained of very severe pain. It was analyzed that the more severe pain of female students was caused by excessive schoolwork and fear of exams. However, more than 90% of them did not receive fundamental treatment, such as 66% of them just referenced, and 28% of them were solved with painkillers.

Menstrual pain is divided into primary menstrual pain, which shows periodic pain during menstruation without any special signs of abnormality in the pelvis, and secondary menstrual pain, which is associated with pathological changes in the pelvis.

There are several theories about the etiology of the primary menstrual pain, the theory that progesterone deficiency is the cause, the theory that it is caused by excessive secretion of estrogen and androgens, the theory that the cause is excessive secretion of prostaglandin, a pain-causing substance, vitamin B. There is a theory that nutritional deficiencies such as complexes or essential fatty acids are the cause, and it is generally considered that the above factors act in combination.

Among the etiologies of primary menstrual pain, the most prevalent theory is that the increase in the production of prostaglandin in the endometrium is the cause. Prostaglandin, which increases during menstruation, causes a strong contraction of the uterine muscles and causes pain.

Therefore, primary menstrual pain can be treated by inhibiting cyclooxygenase (COX), an enzyme that produces prostaglandins, and the principle of action of analgesics (NSAIDs; nonsteroidal anti-inflammatory drugs) used for menstrual pain. Is this.

Secondary menstrual pain is a periodic menstrual pain associated with abnormal signs in the pelvic cavity. The causes include endometriosis, adenomyosis, and intrauterine devices.

As for the relief and treatment of primary menstrual pain, which accounts for the majority of menstrual pain, symptomatic therapy (對症療法) in which the lower abdomen is warmed, cold food is avoided, light exercise, and a warm shower to aid blood circulation in the body, and prostaglandin inhibitors are administered. Methods, estrogen therapy, progesterone therapy, testrosterone therapy, and administration of a uterine contraction inhibitor to maintain anovulation by inhibiting ovulation are widely known.

Among these, the most common method of treatment by taking painkillers (aspirin-based or acetaminophen-based) that interferes with the synthesis of prostaglandins is used, but those who are allergic to aspirin-based drugs or have stomach ulcers cannot use it. Aminophene is unfavorable because it may cause side effects of liver or kidney damage when taken more than the recommended dose, and so dependence on pain relievers or long-term use may cause side effects.

In addition, as another known treatment, the method of administering melatonin (N-acetyl-5-methoxytryptamine) disclosed in Korean Patent No. 0171408, serotonin (5- Hydroxytryptamine).

However, methods of administering hormones or neurotransmitters such as melatonin and serotonin during the corpus luteum formation stage have the effect of relieving not only menstrual pain, but also overall pain relief, chronic fatigue and depression, etc., while the safety of hormones etc. is directly administered. There was a drawback that it was not 100% sure that it could not be easily taken at all times because the manufacturing cost was high.

On the other hand, from the point of view of Oriental medicine, the circulation of blood in the vein in the physiological state is "flowing like water" and "the circulation of blood veins does not cause disease", and when blood clots appear, blood flow worsens due to blood clots and circulation disorders. As the pathology of unpleasant flow appeared, the principle of treatment was to help blood circulation to eliminate blood stagnation and relieve the increase in mass.

Accordingly, the inventors of the present invention have developed a composition that supports blood circulation and has an effect of suppressing skin troubles, which is the greatest concern of women, while solving the root cause of menstrual pain by using extracts derived from natural products with warm properties based on long clinical experience. By providing, it was intended to invent a composition for relieving menstrual pain that women suffering from menstrual pain can continuously and voluntarily consume.

Korean Patent Registration No. 10-0171408 Republic of Korea Patent Publication No. 10-2001-0024462

The object of the present invention is red beet ( Beta vulgaris; or beetroot, hereinafter referred to as red beet), gyeji (桂枝), dansam (丹參, Salvia miltiorrhizae Radix ), peony (芍藥, Paeonia lactiflora ), bokryeong (茯, Wolfiporia extensa) ) And safflower (紅花, Carthami Flos ) to provide a composition for the prevention or improvement of menstrual pain and skin troubles comprising an extract.

Another object of the present invention is to provide a pharmaceutical composition for the prevention or treatment of menstrual pain comprising the composition.

Another object of the present invention is to provide a food composition for preventing or improving menstrual pain and skin troubles comprising the composition.

One aspect of the present invention for achieving the above object provides a composition for preventing or improving menstrual pain and skin problems, including extracts of red beet ( Beta vulgaris ) and gyeji (桂枝).

In the present invention, the “red beet ( Beta vulgaris )” is also called beetroot, and leaves have been used for wound healing since the time of Hippocrates in ancient Greece, and in ancient Rome, beet was used as an antipyretic and diuretic, and the representative longevity of Russia It is a food that has been used for a long time, such as being regarded as a food.

The red beet is rich in betaine, so it can help to remove impurities in the blood by lowering cholesterol and triglyceride levels, and is known to have a strong antioxidant effect. It also contains a large amount of iron and folic acid, which makes it a good food for women.

In the present invention, the “gye-ji” refers to a young branch of a broiler tree (肉桂, Cinnamomum cassia Presl ), and is known to have an effect of facilitating blood supply to the peripheral blood vessels of the hands and feet.

Specifically, the composition may further include extracts of dansam (丹參, Salvia miltiorrhizae Radix ), peony (芍藥, Paeonia lactiflora ), bokryeong (茯, Wolfiporia extensa ) and safflower (紅花, Carthami Flos ).

In the present invention, the “dansam (丹參, Salvia miltiorrhizae Radix )” is a major medicinal agent for improving blood circulation, heart and liver functions, and has excellent diet effect by suppressing triglycerides. From an oriental medical point of view, dansam is bitter and subtle, and enters the heart and liver, and enters the heart (heart) and liver gyeong (肝經), and enters into the heart (heart) and liver gyeong (活血祛瘀), Yanghyeolsoong (凉血消癰), Yanghyeolansin It is known to have the efficacy of 安神). That is, the Dansam is associated with hyperlipidemia, heart disease, and brain disease as well as diseases caused by blood clots in Western medicine, and thus has a pharmacological effect on this. Danseng is known to improve cardiac function and can be applied to emergency treatment of myocardial infarction, and it is known that it can improve the hemodynamic characteristics of ischemic patients by forming antithrombosis and improving hemodynamics.

In the present invention, the "peony (芍藥, Paeonia lactiflora )" is a perennial herbaceous plant belonging to the Buttercup family, and in oriental medicine, the root is used as a medicine. Ingredients include paeoniflorin as a glycoside and paeonine, an alkaloid, and tannins, resins, and benzoic acids. As a pharmacological action, it weakened the contraction force on the smooth muscles of the stomach and uterus of the rat, and showed antispasmodic effect on the intestine of the rabbit. The glycoside component inhibits the central nervous system. In addition, it has antimicrobial action and inhibits the development of Staphylococcus aureus, Shigella, hemolytic streptococcus, and pneumococci.

Yakseong is cold, and the taste is sour and bitter. It has an analgesic effect on gastroenteritis and convulsive pain in the stomach. It is effective when there is abdominal pain, diarrhea, and abdominal pain due to digestive disorders. It is effective even when there is abdominal pain and post-severe symptoms due to dysentery. It shows the effect of blood, pain, and pain in women's menstrual irregularities and uterine bleeding. It is also used for chronic hepatitis and is known to be used for pain in the liver.

In the present invention, the "bokryeong (茯, Wolfiporia extensa )" belongs to the mushroom family, and after 3 to 10 years after cutting the pine tree, it is a sclerotia that grows by parasitic at the root, and the shape is not constant. The surface is dark brown, and the inside is gray-white fleshy granular.

The bark is called Bokryeongpi, and the fungus wrapped around the pine root inside is called Bokshin (茯神), the white inside is called Baekbokryong, and the red one is called Jeokbokryong. Yakseong is ordinary and tastes sweet and dull. Bokryeong has a gentle diuretic effect, so it is effective when the digestive system is weak and there is swelling in the body, and it is also effective in nephritis, cystitis, and urethritis. In addition, it is known to treat chronic bronchitis and bronchiectasis, which are symptoms of difficult breathing because it has expectorant action, in combination with drugs for expectorant and antitussive.

In the present invention, the "safflower (紅花, Carthami Flos )" is a safflower ( Carthamus tinctorius Linne ) It is an ornamental flower of (Asteraceae Compositae). Safflower is known to relieve blood stagnation, improve blood circulation, relieve joint inflammation, and have an effect on blood circulation and menstrual irregularities.

In addition, specifically, the composition of the present invention is Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus sakei, and Lactobacillus sakei In the group consisting of pectin, fructooligosaccharide, alabinogalactan, skim milk, glucose and lactose as prebiotics, which may further include a probiotic mixture comprising Lactobacillus rhamnosus GR-1 (Lactobacillus rhamnosus GR-1). It may be included in the composition as a mixture of one or more selected ones, but is not limited thereto.

In the present invention, specifically, the extract may be extracted with water, a lower alcohol of C ₁ to C ₄ , or a mixed solvent thereof. More specifically, it may be an aqueous alcohol solution having 1 to 5 carbon atoms such as 30 to 80% ethanol, and most specifically, an aqueous ethanol solution of 45%, but is not limited thereto.

In the case of using ethanol as the extraction solvent, it is possible to increase stability, as well as to show excellent suitability for use as a composition of food or pharmaceuticals because it is harmless to the human body, and increase costs such as strict process control for securing stability. The economic effect can be improved as well as does not occur.

Specifically, in the extraction process of the extract, one or more methods selected from the group consisting of cold needle, warm needle, heating, reflux, and ultrasonic extraction may be used alone or in combination, and are not limited thereto, and may be appropriately changed and applied as necessary. I can.

In this case, the extraction process may be a reflux extraction method, but is not limited thereto, and a cold needle extraction method, a hot needle extraction method, a pressure extraction method, or an ultrasonic grinding extraction method may also be used. In addition, after adding a fractionation solvent to the extract prepared by the above extraction method, that is, to the crude extract, for example, hexane, chloroform, ethyl acetate, butanol and water were added in order, and then layer-separated hexane fraction, chloroform fraction, ethyl acetate fraction, butanol A method of obtaining a fraction and a water fraction can be carried out.

In addition, after the extraction or fractionation process is performed, the extract can be concentrated or removed by performing a vacuum filtration process or further concentration and/or lyophilization to remove the solvent, and the obtained composition can be rapidly frozen until use. It can be stored in a deep freezer.

In the present invention, the term “prevention” refers to a reduction in the occurrence of pathological cells in an animal, or damage or loss of cells. Prevention can be complete or partial. In the present specification, it may mean a phenomenon in which menstrual pain and/or skin troubles are reduced compared to the case where the composition of the present invention is not used.

The “treatment” refers to improving one or more symptoms of menstrual pain and/or skin trouble, or preventing the progression of symptoms, and may encompass the meaning of a commonly used treatment.

Another aspect of the present invention provides a pharmaceutical composition for the prevention or treatment of menstrual pain comprising the composition.

The pharmaceutical composition may further include a carrier, an excipient, and a diluent used in the preparation of a conventional pharmaceutical composition.

Examples of the carrier, excipient and diluent include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, Polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, or mineral oil, but are not limited thereto.

In addition, the composition may be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, and aerosols, external preparations, suppositories, and sterile injectable solutions.

The solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and these solid preparations contain at least one excipient, such as starch, calcium carbonate, sucrose, lactose, in the composition and its fractions, Alternatively, it can be prepared by mixing gelatin or the like. In addition to the above excipients, lubricants such as magnesium stearate and talc may be used.

As the liquid formulation for oral administration, a suspension, a liquid solution, an emulsion, a syrup, etc. may be used, and various excipients, such as a wetting agent, a sweetening agent, a fragrance, a preservative, etc., may be used in addition to water and liquid paraffin, which are simple diluents. have.

The formulation for parenteral administration may be a sterile aqueous solution, a non-aqueous solvent, a suspension, an emulsion, a lyophilized formulation, or a suppository. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate may be used. As a base for the suppository, witepsol, macrogol, tween 61, cacao butter, laurin paper, and glycerogelatin may be used.

The pharmaceutical composition including the composition for preventing or improving menstrual pain and skin troubles may be administered to a subject in a pharmaceutically effective amount. The “pharmaceutically effective amount” refers to an amount sufficient to treat a disease with a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is the type of disease, severity, drug activity, drug Sensitivity, time of administration, route of administration and rate of excretion, duration of treatment, factors including co-used drugs and other factors well known in the medical field.

The pharmaceutical composition may be administered as an individual therapeutic agent or administered in combination with other therapeutic agents, may be administered sequentially or simultaneously with a conventional therapeutic agent, and may be administered single or multiple. It is preferable to administer an amount capable of obtaining the maximum effect in a minimum amount without side effects in consideration of all the above factors, and this can be easily determined by a person skilled in the art.

The preferred dosage of the therapeutic composition of the present invention varies depending on the condition and weight, the degree of disease, the form of the drug, the route of administration and the duration, but may be appropriately selected by a person having ordinary knowledge in the technical field to which the present invention belongs. have. Preferably, the therapeutic composition of the present invention is preferably administered 5 to 15g per day. Administration may be administered once a day, or may be divided several times, but the best effect is when 3g is administered three times a day on an empty stomach. The dosage and the number of administrations do not limit the scope of the present invention in any way.

Another aspect of the present invention provides a food composition for preventing or improving menstrual pain and skin troubles, comprising the composition.

In the present invention, the term food refers to a natural product or processed product containing one or more nutrients, and preferably refers to a state that can be eaten directly through a certain degree of processing, and as a general meaning, It is intended to include all functional foods, beverages, food additives and beverage additives.

Foods of the present invention include, for example, various foods, beverages, gums, teas, vitamin complexes, and health functional foods. In addition, foods in the present invention include special nutritional foods (e.g., formulas, infant foods, etc.), processed meat products, fish meat products, tofu, muk, noodles (e.g., ramen, noodles, etc.), health supplements, seasoning foods ( Example, soy sauce, miso, red pepper paste, mixed sauce, etc.), sauces, confectionery (eg, snacks), dairy products (eg, fermented milk, cheese, etc.), other processed foods, kimchi, pickles (various kimchi, pickles, etc.), beverages ( Examples include, but are not limited to, fruit, vegetable beverages, soy milk, fermented beverages, etc.), and natural seasonings (e.g., ramen soup, etc.). The foods, health functional foods, beverages, food additives and beverage additives are conventionally manufactured. It can be manufactured by the method.

In the present invention, the health functional food refers to a food group or food composition that has added value to act and express the function of the food by using physical, biochemical, biotechnological techniques, etc. It refers to foods that are designed and processed to sufficiently express the gymnastic function for recovery, etc. to the living body. The health functional food may contain food additives acceptable for food, and may further include suitable carriers, excipients and diluents commonly used in the manufacture of health functional foods.

In the present invention, a beverage refers to a generic term for drinking to quench thirst or to enjoy taste, and is intended to include a health functional beverage. The beverage is an essential component in the indicated ratio, in addition to containing the composition as an active ingredient, there is no particular limitation on other components, and may contain various flavoring agents or natural carbohydrates as an additional component, like a conventional beverage.

Examples of the above natural carbohydrates include monosaccharides, such as disaccharides such as glucose and fructose, such as maltose, sucrose, and the like, and polysaccharides, such as dextrin, cyclodextrin, and the like, and conventional sugars, and These are sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those described above, natural flavoring agents (taumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.)) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The ratio of the natural carbohydrate may be generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention In addition, the composition of the present invention is used to prepare natural fruit juice, fruit juice beverage, and vegetable beverage. It may contain additional pulp.

In addition to the above, the food composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavors and natural flavoring agents, coloring agents and heavy weight agents (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid, and Salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like may be contained. These components may be used independently or in combination. The proportion of these additives is not so important, but may be selected in the range of 0 to 20 parts by weight per 100 parts by weight of the composition of the present invention.

In the present invention, the health functional beverage refers to a beverage group or a beverage group that has added value to act and express the function of the beverage for a specific purpose by using physical, biochemical, and biotechnological techniques, etc. It refers to a beverage that has been designed and processed to sufficiently express body control functions related to and recovery.

Another aspect of the present invention relates to a method for preparing a composition for preventing or improving menstrual pain and skin troubles, comprising the steps of extracting red beet ( Beta vulgaris ) and gyeji (桂枝) with 10 to 90% ethyl alcohol to provide.

Specifically, the extraction step may be to extract one or more medicinal materials selected from the group consisting of red beet, gyeji, dansam, peony, bokryeong and safflower, and more specifically, 60 parts by weight of red beet, 24 parts by weight of gyeji, sweet ginseng 18 parts by weight of peony, 18 parts by weight of peony, 12 parts by weight of bokryeong, and 9 parts by weight of safflower may be mixed and extracted and prepared, but the present invention is not limited thereto and may be appropriately changed and applied as necessary.

In one embodiment of the present invention, 400 parts by weight of 45% ethyl alcohol was added to 60 parts by weight of red beet, 24 parts by weight of ginseng, 18 parts by weight of dansam, 18 parts by weight of peony, 12 parts by weight of bokryeong and 9 parts by weight of safflower, and stirred well. Then, after reflux extraction for 3 hours at an extraction temperature maintained at 80 to 90°C by heating, the filtrate was separated.

Thereafter, the extract was concentrated under reduced pressure at 55 to 65° C., and then freeze-dried to obtain an extract derived from a natural product in powder form, but is not limited thereto.

The composition of the present invention is manufactured including only natural raw materials that are harmless to the human body, and is characterized in that the active ingredients of the natural raw materials interact to promote the user's blood circulation and treat the underlying cause of menstrual pain.

Specifically, when the composition of the present invention is continuously taken, it is effective in relieving menstrual pain symptoms such as belly pain and back pain that appear in women with menstrual pain by warming the lower abdomen of a woman and relaxing the uterine muscles, and has excellent persistence of the effect, As it is derived from natural products, it is not toxic and does not cause side effects even when applied to the human body, so it can be used for a long time.

In addition, according to an aspect of the present invention, by using the composition as a component of a pharmaceutical composition or a health functional food, the active ingredient derived from natural products contained in a large amount in the composition inhibits skin troubles and improves complex skin. Can be expected.

The effects of the present invention are not limited to the above effects, and should be understood to include all effects that can be deduced from the configuration of the invention described in the detailed description or claims of the present invention.

Hereinafter, the present invention will be described in detail by examples. However, the following examples are only illustrative of the present invention, and the present invention is not limited by the following examples.

Example 1. Preparation of extract derived from natural products containing red beet

In order to prepare the composition for preventing or improving menstrual pain and skin troubles of the present invention, first, extracts derived from natural products including red beets and gyeji were prepared.

Specifically, 400 parts by weight of 45% ethyl alcohol was added to 60 parts by weight of red beet, 24 parts by weight of gyeji, 18 parts by weight of sweet ginseng, 18 parts by weight of peony, 12 parts by weight of bokryeong, and 9 parts by weight of safflower, and stirred well, followed by heat. The filtrate was separated after reflux extraction for 3 hours at an extraction temperature maintained at 80 to 90°C.

Thereafter, the extract was concentrated under reduced pressure at 55 to 65°C, and then freeze-dried to obtain an extract derived from a natural product in powder form.

Example 2. Preparation of a composition containing extracts derived from natural products

By applying the following additional process to the extract from the natural product prepared in Example 1, to prepare a composition for preventing or improving menstrual pain and skin troubles of the present invention.

Specifically, based on 100 parts by weight of the natural product-derived extract of Example 1, 15 parts by weight of a probiotic mixture, 7 parts by weight of enzyme-treated stevia, and 8 parts by weight of acacia-derived dietary fiber were further included to prepare a composition of the present invention.

At this time, the probiotics mixture is Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus sakei (Lactobacillus sakei) and Lactobacillus sakei 1 (Lactobacillus rhamnosus GR-1) is mixed at a weight ratio of 1:2:2:1:1 and a mixture of lactic acid bacteria and a prebiotic fructooligosaccharide at a weight ratio of 3:1 at 20 to 25 ° C. What was prepared by aging for 4 hours was used.

Comparative Example 1. Preparation of composition excluding red beet

The composition of Comparative Example 1 of the present invention was prepared in the same manner as in Example 2 except that the red beet was not included.

Comparative Example 2. Preparation of a composition excluding Bokryeong

The composition of Comparative Example 2 of the present invention was prepared in the same manner as in Example 2, except that Bokryeong was not included.

Comparative Example 3. Preparation of a composition excluding a probiotic mixture

The composition of Comparative Example 3 of the present invention was prepared in the same manner, except that the preparation method of Example 2 was prepared without including a probiotic mixture.

Experimental Example 1. Confirmation of menstrual pain relief effect

In order to confirm the menstrual pain relief effect of the composition of the present invention, the compositions of Example 2 and Comparative Examples 1 to 3 were administered to 40 women aged 17 to 48 who complained of discomfort from menstrual pain.

Specifically, the 40 persons were divided into 10 persons in consideration of the age group, and each Example and Comparative Example composition were taken 3 g each 3 times daily on an empty stomach, and were consumed for a total of 3 months.

Specific indicators for confirming the effect of relieving menstrual pain include whether the intensity of menstrual pain has weakened, whether the duration of menstrual pain has been shortened, whether abdominal discomfort has decreased, whether the amount of cold cramps has decreased, the color and degree of clumping of menstrual blood, It was checked whether the amount of menstrual blood increased, and the average lower abdominal temperature during the menstrual period was measured.

Each of the four groups of 10 people ingested the composition for 3 months, and compared with before ingestion, a 10-point score method was used to give a higher score as the satisfaction level was higher. At this time, as the color of menstrual blood was closer to red, the degree of clumping was less, and the amount of menstrual blood increased, a higher score was given.

This is because the uterus is overconstricted during the process of discharging the blood stagnation formed in the body. As the amount of menstrual blood increases, the amount of blood stagnation in the body decreases, causing the endometrium. This is because it improves and reduces pain.

Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Menstrual pain intensity 9.5 8.8 9.1 9.3 Period of menstrual pain 9.2 8.5 9.0 9.0 Abdominal discomfort 9.1 8.0 8.7 9.0 Cold treat 9.6 7.6 8.5 9.3 The color of menstrual blood and
Clumping degree 9.8 8.8 9.1 9.4 Amount of menstrual blood 9.2 6.6 8.9 9.2 Average lower abdomen temperature +1.2℃ +0.2℃ +0.8℃ +1.0℃

As shown in Table 1, it was confirmed that the composition of Example 2 of the present invention exhibited remarkably excellent effects in all identifiable indicators related to menstrual pain compared to the case of administering the composition of Comparative Example. In particular, comparison excluding red beet When Example 1 was compared with the case where Example 2 was administered, significant differences were observed in the items related to abdominal discomfort, the amount of menstrual blood, and cold treatment, which is rich in nitrates that produce nitric oxide (NO). Therefore, it seems to have a great influence on the index that is deeply affected by the expansion of blood vessels.

In addition, Comparative Example 2 except for Bokryeong showed a significant difference in the items related to the amount of cold daeja and the state of menstrual blood, and it was confirmed that the overall effect was reduced.

Comparative Example 3 It was also confirmed that the overall effect was reduced in all items than the composition of Example 2 of the present invention.

Experimental Example 2. Confirmation of skin improvement effect

In order to check whether the skin can be improved when the composition of the present invention is continuously administered, the composition of Example 2 and the composition of Comparative Examples 1 to 3 were administered to 25 women in their 20s to 40s for 1 month, and the skin improvement effect was improved. Confirmed.

Specifically, the 25 people were divided into a group of 5 people each, and the compositions of Example 2 and Comparative Examples 1 to 3 were administered on an empty stomach 3 times a day, but only the group administered Example 2 on an empty stomach 3 times a day. It was subdivided into an administration group and two groups ingested with meals twice a day (Example 2-1).

In order to confirm the skin improvement effect, the degree of skin moisturization and trouble occurrence was measured, and a 10-point scoring method was used to give a higher score as the effect was excellent.

division Example 2 Example 2-1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Skin moisturizing effect 9.4 8.7 8.6 9.0 9.1 Relieve skin troubles 9.5 8.6 7.7 8.2 9.4 Overall satisfaction 9.4 8.1 7.5 8.5 9.2

As shown in Table 2, when the composition of Example 2 of the present invention was taken three times a day on an empty stomach, excellent moisturizing effect and trouble alleviating effect were confirmed. On the other hand, it was confirmed that this effect was reduced in Comparative Example 1 excluding red beet or Comparative Example 2 excluding Bokryeong. Furthermore, as can be seen from the results of Example 2-1, the composition of the present invention was 1 on an empty stomach. It was confirmed that the best effect can be obtained when ingested three times a day, and otherwise, only the effect of the comparative example can be expected, and the intake method is also very important.

Therefore, when the above results are summarized, the composition of the present invention shows a remarkable improvement effect of various indicators and skin problems related to menstrual pain, and it was confirmed that it can be used as a pharmaceutical composition or food composition for relieving menstrual pain.

The above description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains will be able to understand that other specific forms can be easily modified without changing the technical spirit or essential features of the present invention will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not limiting. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as being distributed may also be implemented in a combined form.

The scope of the present invention is indicated by the claims to be described later, and all changes or modified forms derived from the meaning and scope of the claims and the concept of equivalents thereof should be construed as being included in the scope of the present invention.

Claims (5)

Red beet ( Beta vulgaris ), Gyeji (桂枝), Dansam (丹參, Salvia miltiorrhizae Radix ), peony (芍藥, Paeonia lactiflora ), Bokryeong ( Wolphnia extensa ) and safflower (紅花, Carthami Flos ) extracts;
Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus sakei and Lactobacillus GR-1 (Lactobacillus rhamnosus GR-1) A probiotic mixture comprising 1); And
Fructooligosaccharide; containing, a food composition for preventing or improving menstrual pain and skin troubles. The method of claim 1,
The composition further comprises a skin moisturizing effect, food composition. The method according to claim 1 or 2,
The extract will be extracted with water, C ₁ to C ₄ lower alcohol, or a mixed solvent thereof. delete delete