CN106266239B - Improve the composition and its preparation method and application of memory - Google Patents
Improve the composition and its preparation method and application of memory Download PDFInfo
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- CN106266239B CN106266239B CN201610820506.6A CN201610820506A CN106266239B CN 106266239 B CN106266239 B CN 106266239B CN 201610820506 A CN201610820506 A CN 201610820506A CN 106266239 B CN106266239 B CN 106266239B
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- ginseng
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- fructus lycii
- radix notoginseng
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The present invention relates to a kind of compositions and its preparation method and application for improving memory, belong to pharmaceutical technology field.The effective component of the composition is prepared by the medicinal material of following parts by weight: 2-6 parts of Schisandra chinensis, 3-9 parts of ginseng, 1-3 parts of Radix Notoginseng, 6-12 parts of fructus lycii.Fang Zhong, for this etiology and pathogenesis of senile dementia, selecting Zishen fill fine, tonifying Qi to dissipate the stasis of blood is therapy, yin, nourishing kidney essence are held back as monarch drug in a prescription using Schisandra chinensis QI invigorating, with ginseng and Radix Notoginseng tonifying Qi intelligence development, promoting blood circulation to remove blood stasis altogether for ministerial drug, using fructus lycii tonifying kidney and benefiting sperm, healthy tendency is fostered as adjutant, to promote the recovery of memory of elderly person and cognitive disorder, improves the Chinese medicine of memory effect for exploitation and health food provides foundation.
Description
Technical field
The present invention relates to medicine and food technology fields, more particularly to a kind of composition for improving memory and its preparation side
Method and application.
Background technique
Failure of memory, Chinese medicine claim amnesia, forgetful, happiness to forget.This disease is clinical common with the elderly, therefore is frequently referred to old silly
It is slow-witted.China's traditional medicine thinks that senile dementia belongs to the scope of Chinese medicine " dementia ", and " hiding of Plain Questions five generates a piece " has cloud: " all
Marrow person, comes under brain ", " Ling Shu Miraculous Pivot or Divine Axis sea opinion " is said: " the brain being the reservoir of the marrow, it is defeated on be its lid, under in windy mansion ", " Elementary Medicine "
Cloud: " brain person, the sea of marrow, all marrows come under brain, thus up to brain, down toward tail sacrum, all road of marrow lifting ", it is discussed above equal
Illustrate that brain is that marrow collects place.It is used it follows that will have a direct impact on cerebral swelling whether brains fill prosperous, the main memory of human brain
Must be using brains as where material base and source, only brain abundance, brain must nourish, the normal learning and memory of competence exertion
The functions such as thinking.Filling for brains is prosperous, has relationship with the vital organs of the human body, but be especially to want with kidney.The kidney being the origin of congenital constitution, envelope hiding
This, the raw marrow of store essential substances and on pass through brain, as " Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " cloud: " people is begun life, first at essence, essence at and brains are raw ", Tang, the Qing Dynasty
Rong Chuan also says " why things is not forgotten, this memory is relied, and remembers wherein, then in kidney essense in its " ancient Chinese medical classics essential ideas ".Kidney-tonifying and sperm-producing,
Turn to marrow, and hiding in brain ", it is seen that kidney essense is the main matter source of replenishing the brain and spinal cord, and essence fills that then marrow is full, and it is empty that essence loses then marrow.
Therefore clinically should be using kidney tonifying, essence replenishing as basic therapy, while the elderly has the disease of qi and blood stagnation due to Qi deficiency physique more, resistance
Kidney essense has been hindered to take a tonic or nourishing food to build up one's health brain.
Summary of the invention
Based on this, the purpose of the present invention is to provide a kind of compositions for improving memory, and the composition is for the elderly's
Feature has the function of preferably improving memory.
A kind of composition improving memory, the effective component of the composition are prepared by the medicinal material of following parts by weight:
2-6 parts of Schisandra chinensis, 3-9 parts of ginseng, 1-3 parts of Radix Notoginseng, 6-12 parts of fructus lycii.
The present invention combines modern medicine according to traditional Chinese medicine theory, has selected Schisandra chinensis, ginseng, Radix Notoginseng and fructus lycii
Compatibility is carried out, Fang Zhong:
Schisandra chinensis, sour, sweet, warm-natured, return lung, the heart, kidney channel.With astringency inducing, the function of supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves
Effect.For long-last cough and virtual asthma, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, interior heat disappears
Yearningly, palpitation and insomnia etc..Schisandra chinensis main component is lignanoid and polysaccharide, and it is obvious that modern pharmacology research shows that Schisandra chinensis has
Fat-reducing liver-protecting, tranquilizing and allaying excitement and oxidation resistant effect.In we reuse Schisandra chinensis be monarch drug in a prescription, it is intended to play its QI invigorating hold back yin,
The effect of nourishing kidney essence.
Ginseng, sweet in flavor, slight bitter, mild-natured, tepor, returns spleen, lung, the heart channel of Hang-Shaoyin.Effect is to reinforce vital energy, and reinforces the spleen to benefit the lung, promotes the production of body fluid only
Yearningly, tranquilize the mind and promote the intelligence mends all void.The main component of ginseng is ginsenoside, polysaccharide and volatile oil.Radix Notoginseng, sweet in flavor, slight bitter, property
Temperature returns liver, stomach meridian.Have effects that dissipating stasis and stanching bleeding, detumescence ding-tong, is mainly used for treating bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, spits blood, spit
The diseases such as blood, traumatic hemorrhage, chest and abdomen shouting pain.Modern pharmacy research confirms that Radix Notoginseng mainly includes saponin(e, flavone compound, can
Improve myocardial blood supply and expansion coronary artery, furthermore sitosterol and daucosterol also have the function of reducing blood lipid in Radix Notoginseng.With people in side
Ginseng and Radix Notoginseng are ministerial drug altogether, while assisting monarch drug in a prescription Schisandra chinensis performance QI invigorating to consolidate effect, play tranquilize the mind and promote the intelligence, fill up brain
Hollow effect.
Fructus lycii, it is sweet in flavor, mild-natured；Return liver, kidney, lung channel.With tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity, moistening lung and producing body fluid and other effects.With
In consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.The main component of fructus lycii is Chinese holly
Qi polysaccharide, glycine betaine, carotenoid and carotenoids ester and multivitamin and amino acid, lot of documents report, fructus lycii
With immunity is improved, nervous function, liver protection, lowering blood pressure and blood fat, hypoglycemic and anti-aging effect are adjusted.This
Healthy tendency to tonifying kidney and benefiting sperm, is fostered using fructus lycii as adjutant by side, plays anti-aging by improving body immunity, increases
The effect of strong memory capability.
Accordingly, it is monarch drug in a prescription that the present invention, which reuses Schisandra chinensis, it is intended to play the effect of its QI invigorating holds back yin, nourishing kidney essence；With ginseng
Altogether it is ministerial drug with Radix Notoginseng, while assisting monarch drug in a prescription Schisandra chinensis performance QI invigorating to consolidate effect, plays tranquilize the mind and promote the intelligence, fills up brain sky
Empty effect；And using fructus lycii as adjutant, to tonifying kidney and benefiting sperm, healthy tendency is fostered, is prolonged by improving body immunity and playing
Slow aging, the effect for enhancing memory capability.
The effective component of the composition is prepared by the medicinal material of following parts by weight in one of the embodiments:
6 parts of Schisandra chinensis, 9 parts of ginseng, 1 part of Radix Notoginseng, 6 parts of fructus lycii.
The preparation method of the bright composition for also disclosing above-mentioned improvement memory of this law, comprising the following steps:
Schisandra chinensis is extracted: Schisandra chinensis weighed by weight, and the ethanol water that volumn concentration is 60%-90% is added,
50-80 DEG C of extraction, filtering, filtrate concentration obtain Schisandra chinensis liquid extract；
Ginseng extracts: weighing ginseng by weight, the ethanol water that volumn concentration is 60%-100%, 70- is added
100 DEG C of extractions, filtering, filtrate concentration obtain ginseng liquid extract；
Radix Notoginseng is extracted: weighing Radix Notoginseng by weight, the ethanol water that volumn concentration is 30%-70%, 50-90 is added
DEG C extract, filtering, filtrate concentration, obtain Radix Notoginseng liquid extract；
Fructus lycii is extracted: weighing fructus lycii by weight, the ethanol water that volumn concentration is 0%-30%, 80-100 is added
DEG C extract, filtering, filtrate concentration, obtain fructus lycii liquid extract；
Mixing: taking above-mentioned Schisandra chinensis liquid extract, ginseng liquid extract, Radix Notoginseng liquid extract and fructus lycii liquid extract, is uniformly mixed, i.e.,
?.
Above-mentioned preparation method extracts the effective component in medicinal material, improves the convenience that patient takes, and should
Preparation method is simple for process, is easy to carry out industrial production.
During the Schisandra chinensis is extracted in one of the embodiments, Schisandra chinensis is weighed by weight, is added by every gram of Schisandra chinensis
Enter the ethanol water that 10-18ml volumn concentration is 70%-80%, 60-70 DEG C of extraction 1-3hr is filtered, and filtrate concentration obtains
Schisandra chinensis liquid extract.
During the ginseng extracts in one of the embodiments, ginseng is weighed by weight, and 7- is added by every gram of ginseng
13ml volumn concentration is the ethanol water of 75%-85%, and 80-90 DEG C is extracted 1-3 times, each 1-3hr, and filtering merges filter
It is concentrated after liquid, obtains ginseng liquid extract.
During the Radix Notoginseng is extracted in one of the embodiments, Radix Notoginseng is weighed by weight, and 6- is added by every gram of Radix Notoginseng
10ml volumn concentration is the ethanol water of 45%-55%, and 65-75 DEG C is extracted 1-3 times, each 1-3hr, and filtering merges filter
It is concentrated after liquid, obtains Radix Notoginseng liquid extract.
During the fructus lycii is extracted in one of the embodiments, fructus lycii is weighed by weight, and 7- is added by every gram of fructus lycii
13ml water, 90-100 DEG C is extracted 1-3 times, each 1-3hr, filtering, is concentrated after merging filtrate, is obtained fructus lycii liquid extract.
The invention also discloses combinations of the above objects to have the pharmaceutical preparation or health care product system for improving memory effect in preparation
Application in agent.
The pharmaceutical preparation is oral solution, hard capsule, soft capsule, tablet, pill, dripping pill in one of the embodiments,
Agent, granule, powder, honey ointment agent or distillate medicinal water.
The health-care preparation is tea bag or vina in one of the embodiments,.
Compared with prior art, the invention has the following advantages:
The composition of improvement memory of the invention selects Zishen fill fine, tonifying Qi for this etiology and pathogenesis of senile dementia
Dissipating the stasis of blood is therapy, holds back yin, nourishing kidney essence as monarch drug in a prescription using Schisandra chinensis QI invigorating, is altogether with ginseng and Radix Notoginseng tonifying Qi intelligence development, promoting blood circulation to remove blood stasis
Ministerial drug using fructus lycii tonifying kidney and benefiting sperm, fosters healthy tendency as adjutant, to promote the recovery of memory of elderly person and cognitive disorder.
The anti-Fatigue Composition carries out on the basis of Chinese medicine theory, then through mouse step-through test and water maze laboratory
Functional component screening and formula design, what is finally just obtained has the Chinese medicine preparation for clearly improving memory, improves for exploitation
The Chinese medicine and health food of memory provide foundation.
Also, after cooperating each raw material at a specific ratio, there is extraordinary effect, it is oral to give the composition 30 days
Afterwards, water maze laboratory is carried out, mouse finds the time of platform compared with model group, has significant difference.
Specific embodiment
It is explained in detail below in conjunction with specific embodiment and illustrates the present invention, but any restrictions are not caused to the present invention.
Bulk pharmaceutical chemicals employed in following embodiment and auxiliary material are common commercially available.
Embodiment 1
A kind of composition improving memory, is prepared by following medicinal material:
Schisandra chinensis 6g, 9 g of ginseng, 1 g of Radix Notoginseng, 6 g of fructus lycii.
Above-mentioned raw materials are followed these steps to prepare:
Schisandra chinensis is extracted: weighing Schisandra chinensis by weight, it is 75% that 14ml volumn concentration, which is added, by every gram of Schisandra chinensis
2hr, filtering are extracted in ethanol water, 65 DEG C of water-baths, and filtrate concentration obtains Schisandra chinensis liquid extract.
Ginseng extracts: weighing ginseng by weight, the ethanol water that 10ml volumn concentration is 80% is added by every gram of ginseng
Solution, 85 DEG C of water-baths are extracted 2 times, each 1hr, filtering, are concentrated after merging filtrate, are obtained ginseng liquid extract.
Radix Notoginseng is extracted: weighing Radix Notoginseng by weight, the ethanol water that 8ml volumn concentration is 50% is added by every gram of Radix Notoginseng
Solution, 70 DEG C of water-baths are extracted 2 times, each 2hr, filtering, are concentrated after merging filtrate, are obtained Radix Notoginseng liquid extract.
Fructus lycii is extracted: fructus lycii weighed by weight, and 10ml water is added by every gram of fructus lycii, 100 DEG C are extracted 3 times, each 3hr,
It filters, is concentrated after merging filtrate, obtains fructus lycii liquid extract.
Mixing: taking above-mentioned Schisandra chinensis liquid extract, ginseng liquid extract, Radix Notoginseng liquid extract and fructus lycii liquid extract, is uniformly mixed, and does
The dry composition A to get improvement memory.
Embodiment 2
A kind of composition improving memory, is prepared by following medicinal material:
Schisandra chinensis 2g, ginseng 9 g, Radix Notoginseng 3g, 12 g of fructus lycii.
It prepares according to the method for embodiment 1, obtains the composition B for improving memory.
Comparative example 1
This comparative example prepares a kind of composition, and essentially identical with the composition of the improvement memory of embodiment 1, difference exists
In the composition of this comparative example is prepared by following medicinal material:
Schisandra chinensis 6g, 9 g of ginseng, 1 g of Radix Notoginseng.
Composition C is prepared referring to the method for embodiment 1.
Comparative example 2
This comparative example prepares a kind of composition, and essentially identical with the composition of the improvement memory of embodiment 1, difference exists
In the composition of this comparative example is prepared by following medicinal material:
Schisandra chinensis 6g, 1 g of Radix Notoginseng, 6 g of fructus lycii.
Composition D is prepared referring to the method for embodiment 1.
Comparative example 3
This comparative example prepares a kind of composition, and essentially identical with the composition of the improvement memory of embodiment 1, difference exists
In the composition of this comparative example is prepared by following medicinal material:
9 g of ginseng, 1 g of Radix Notoginseng, 6 g of fructus lycii.
Composition E is prepared referring to the method for embodiment 1.
Comparative example 4
This comparative example prepares a kind of composition, and essentially identical with the composition of the improvement memory of embodiment 1, difference exists
In the composition of this comparative example is prepared by following medicinal material:
Schisandra chinensis 6g, 9 g of ginseng, 6 g of fructus lycii.
Composition F is prepared referring to the method for embodiment 1.
Comparative example 5
This comparative example prepares a kind of composition, and essentially identical with the composition of the improvement memory of embodiment 1, difference exists
In the composition of this comparative example is prepared by following medicinal material:
Schisandra chinensis 6g, 9 g of ginseng, 1 g of Radix Notoginseng, 6 g of fructus lycii, fructus alpiniae oxyphyllae 6g.
Composition G is prepared referring to the method for embodiment 1.
Experimental example 1
The composition for taking above-described embodiment and comparative example to be prepared carries out mouse step-through test, the method is as follows:
1, experimental animal.
Healthy ICR male mice, 20 ± 2g of weight are provided by Jilin University's Animal Experimental Study center, and credit number is
SCXK-(is lucky) 2015-0005, divides after cage that be put in quiet, temperature and humidity be suitable for, in draughty environment that free water is rationally taken the photograph
Food starts to test after adapting to local environment 7 days.
2, experimental method.
ICR mouse is randomly divided into blank control group (distilled water is given in stomach-filling), composition A group, composition B group, combination
Object C group, composition D group, composition E group, composition F group, composition G group, the continuous gavage for carrying out 30 days by a definite date to mouse are given
Medicine, dosage are that 0.1ml/10g(composition compound concentration is 0.366g/ml).
After 29th day 30 min of stomach-filling, step-through test is carried out.Mouse is put into and keeps away dark instrument septum reset and is put into backwards to hole
Bright room, while starting timer.It is latent with the time that mouse enters timer record when hole reaches darkroom by mistake
Phase.This experiment is recorded in the errors number of mouse in 5 min to mouse 5 min of training.It is carried out after being administered 30 minutes in next day
Second of test.The errors number for recording the incubation period of every mouse and occurring in 5min.
3, experimental result.
The experimental results are shown inthe following table.
1. each group mouse of table keep away dark test result (, n=15)
Note: compared with normal group, P < 0.05 *.
The above results show that compared with the mouse of blank control, mouse keeps away dark examination through the mouse of continuous gavage administration 30 days
Middle errors number is tested to significantly reduce.
Also, in composition of the invention, per the missing of medicinal material simply, all the improvement memory effect of this product is generated certain
Influence, therefore four taste Chinese medicines are indispensable, and increase that medicinal material, effect are also not so good as the compatibility of this four tastes Chinese medicine simply.
Compared with Example 2, using the optimum proportioning of embodiment 1, there is optimal improvement memory effect.
Experimental example 2
The composition A for taking above-described embodiment 1 to be prepared carries out mouse and keeps away dark test, the method is as follows:
1, experimental animal.
Healthy ICR male mice, 20 ± 2g of weight are provided by Jilin University's Animal Experimental Study center, and credit number is
SCXK-(is lucky) 2015-0005, divides after cage that be put in quiet, temperature and humidity be suitable for, in draughty environment that free water is rationally taken the photograph
Food starts to test after adapting to local environment 7 days.
2, experimental method.
ICR mouse is randomly divided into blank control group (distilled water is given in stomach-filling), (distilled water, abdomen are given in stomach-filling to model group
Chamber inject hyoscine 5mg/kg), composition A low dose group, composition A middle dose group, composition A high dose group, by each group
Mouse was by 0.1ml/10g capacity continuous gavage administration 30 days, once a day.(the basic, normal, high dosage formulation concentration difference of composition A
For 0.183g/ml, 0.366 g/ml, 0.732g/ml).
Started to carry out keeping away dark test in stomach-filling the 29th day and the 30th day.Start to train within 29th day, preceding 30 min of training into
Row gastric infusion, after gastric infusion 20min, blank control group mouse intraperitoneal injection of saline, model group and other each groups are small
5mg/kg scopolamine hydrobromide is injected intraperitoneally in mouse.After 10min is injected intraperitoneally, mouse is put into and keeps away dark instrument septum reset backwards to hole
It is put into bright room, while starting timer.It is with the time that mouse enters timer record when hole reaches darkroom by mistake
Incubation period.This experiment is recorded in the errors number of mouse in 5 min to mouse 5 min of training.In gastric infusion the 30th day into
Second of test of row, medication was the same as the 29th day.The errors number for recording the incubation period of every mouse and occurring in 5min.
3, experimental result.
The experimental results are shown inthe following table.
2. each group mouse of table keep away dark test result (, n=15)
Note: compared with blank group, P < 0.01 * *；Compared with model group, #P < 0.05, ##P < 0.01；With middle dose group ratio
Compared with, ▲ P < 0.05, ▲ ▲ P < 0.01.
The above results show that compared with blank group, model group mouse incubation period is obviously shortened (P < 0.01), and errors number is bright
It is aobvious to increase (P < 0.01), show modeling success；Compared with model group, middle and high dosage group mouse incubation period be obviously prolonged (P <
0.05, P < 0.01), errors number significantly reduces (P < 0.05, P < 0.01)；And with the increase of dosage, incubation period is gradually
Extend (low dose group and high dose group respectively compared with middle dose group, P < 0.05, P < 0.01), errors number gradually decreases (low
Dosage group and high dose group are respectively compared with middle dose group, P < 0.05).The experimental results showed that above-mentioned composition, which has, improves note
Recall effect, and there are dose dependents for the effect.
Experimental example 3
The composition for taking above-described embodiment and comparative example to be prepared carries out mouse Morris water maze laboratory, and method is such as
Under:
1, experimental animal.
Healthy ICR male mice, 20 ± 2g of weight are provided by Jilin University's Animal Experimental Study center, and credit number is
SCXK-(is lucky) 2015-0005, divides after cage that be put in quiet, temperature and humidity be suitable for, in draughty environment that free water is rationally taken the photograph
Food starts to test after adapting to local environment 7 days.
2, experimental method.
ICR mouse is randomly divided into blank control group (distilled water is given in stomach-filling), (distilled water, abdomen are given in stomach-filling to model group
Chamber inject hyoscine 5mg/kg), composition A group, composition B group, composition C group, composition D group, composition E group, combination
Object F group, composition G group, by each group mouse by 0.1ml/10g capacity continuous gavage administration 30 days, once a day.Dosage is
0.1ml/10g(composition compound concentration is 0.366g/ml).
In the 25th day progress water maze test of gastric infusion, gastric infusion, gastric infusion are carried out in preceding 30 min of training
After 20min, blank control group mouse intraperitoneal injection of saline, to model group, composition A group, composition B group, composition C
Group, composition D group, composition E group, composition F group, composition G group carry out intraperitoneal injection hyoscine 5mg/kg.Intraperitoneal injection
After 10min, mouse is placed in Morris water maze video tracking test macro WMT-100, the training time that mouse is arranged sets
It is set to 120s, the mouse that terminal is not up in 120s is recorded by 120s.Mouse is placed near platform before testing for the first time,
Climb up it automatically 3 times.Mouse is placed near platform before training every time later, climbs up it independently primary to platform.Every
24 h training 1 time, continues to be administered during training, and medication was the same as the 25th day.The 29th day experimental data is administered in acquisition.Administration the
Platform was removed statistics mouse spatial search capability in 30 days, medication was the same as the 25th day.And record the number of mouse spanning platform time
Experimental result.
2, experimental result.
The experimental results are shown inthe following table.
3 each group Mice water maze orientation navigation of table and explore result (, n=15)
Note: compared with blank group, P < 0.01 * *；Compared with model group, #P < 0.05, ##P < 0.01.
The above results show that compared with model group, it is bright that composition A and the B group of Examples 1 and 2 preparation finds plateau time
It is aobvious to shorten；Also, it increased significantly by platform number.
Also, in composition of the invention, per the missing of medicinal material simply, all the improvement memory effect of this product is generated certain
Influence, therefore four taste Chinese medicines are indispensable, and increase that medicinal material, effect are also not so good as the compatibility of this four tastes Chinese medicine simply.
Compared with Example 2, using the optimum proportioning of embodiment 1, there is optimal improvement memory effect.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. it is a kind of improve memory composition, which is characterized in that the effective component of the composition by following parts by weight medicinal material
It is prepared:
2-6 parts of Schisandra chinensis, 3-9 parts of ginseng, 1-3 parts of Radix Notoginseng, 6-12 parts of fructus lycii；
The effective component of the composition is prepared by the following method to obtain:
Schisandra chinensis is extracted: weighing Schisandra chinensis by weight, the ethanol water that volumn concentration is 60%-90%, 50- is added
80 DEG C of extractions, filtering, filtrate concentration obtain Schisandra chinensis liquid extract；
Ginseng extracts: weighing ginseng by weight, the ethanol water that volumn concentration is 60%-100%, 70-100 is added
DEG C extract, filtering, filtrate concentration, obtain ginseng liquid extract；
Radix Notoginseng is extracted: it weighs Radix Notoginseng by weight, is added the ethanol water that volumn concentration is 30%-70%, 50-90 DEG C
It extracts, filtering, filtrate concentration obtains Radix Notoginseng liquid extract；
Fructus lycii is extracted: it weighs fructus lycii by weight, is added the ethanol water that volumn concentration is 0%-30%, 80-100 DEG C
It extracts, filtering, filtrate concentration obtains fructus lycii liquid extract；
Mixing: take above-mentioned Schisandra chinensis liquid extract, ginseng liquid extract, Radix Notoginseng liquid extract and fructus lycii liquid extract, be uniformly mixed to get.
2. it is according to claim 1 improve memory composition, which is characterized in that the effective component of the composition by with
The medicinal material of lower parts by weight is prepared:
6 parts of Schisandra chinensis, 9 parts of ginseng, 1 part of Radix Notoginseng, 6 parts of fructus lycii.
3. the preparation method of the described in any item compositions for improving memory of claim 1-2, which is characterized in that including following step
It is rapid:
Schisandra chinensis is extracted: weighing Schisandra chinensis by weight, the ethanol water that volumn concentration is 60%-90%, 50- is added
80 DEG C of extractions, filtering, filtrate concentration obtain Schisandra chinensis liquid extract；
Ginseng extracts: weighing ginseng by weight, the ethanol water that volumn concentration is 60%-100%, 70-100 is added
DEG C extract, filtering, filtrate concentration, obtain ginseng liquid extract；
Radix Notoginseng is extracted: it weighs Radix Notoginseng by weight, is added the ethanol water that volumn concentration is 30%-70%, 50-90 DEG C
It extracts, filtering, filtrate concentration obtains Radix Notoginseng liquid extract；
Fructus lycii is extracted: it weighs fructus lycii by weight, is added the ethanol water that volumn concentration is 0%-30%, 80-100 DEG C
It extracts, filtering, filtrate concentration obtains fructus lycii liquid extract；
Mixing: take above-mentioned Schisandra chinensis liquid extract, ginseng liquid extract, Radix Notoginseng liquid extract and fructus lycii liquid extract, be uniformly mixed to get.
4. the preparation method of the composition as claimed in claim 3 for improving memory, which is characterized in that during the Schisandra chinensis is extracted,
Schisandra chinensis is weighed by weight, and it is water-soluble that the ethyl alcohol that 10-18ml volumn concentration is 70%-80% is added by every gram of Schisandra chinensis
Liquid, 60-70 DEG C of extraction 1-3hr, filtering, filtrate concentration obtain Schisandra chinensis liquid extract.
5. the preparation method of the composition as claimed in claim 3 for improving memory, which is characterized in that the ginseng is pressed in extracting
Parts by weight weigh ginseng, and the ethanol water that 7-13ml volumn concentration is 75%-85%, 80-90 is added by every gram of ginseng
It DEG C extracts 1-3 time, each 1-3hr, filters, be concentrated after merging filtrate, obtain ginseng liquid extract.
6. the preparation method of the composition as claimed in claim 3 for improving memory, which is characterized in that the Radix Notoginseng is pressed in extracting
Parts by weight weigh Radix Notoginseng, and the ethanol water that 6-10ml volumn concentration is 45%-55%, 65-75 is added by every gram of Radix Notoginseng
It DEG C extracts 1-3 time, each 1-3hr, filters, be concentrated after merging filtrate, obtain Radix Notoginseng liquid extract.
7. the preparation method of the composition as claimed in claim 3 for improving memory, which is characterized in that the fructus lycii is pressed in extracting
Parts by weight weigh fructus lycii, and 7-13ml water is added by every gram of fructus lycii, and 90-100 DEG C is extracted 1-3 times, each 1-3hr, and filtering merges filter
It is concentrated after liquid, obtains fructus lycii liquid extract.
8. the described in any item compositions of claim 1-2 have the pharmaceutical preparation or health care product system for improving memory effect in preparation
Application in agent.
9. application according to claim 8, the pharmaceutical preparation is oral solution, hard capsule, soft capsule, tablet, pill, drop
Pill, granule, powder, honey ointment agent or distillate medicinal water.
10. application according to claim 8, the health-care preparation is tea bag or vina.
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