CN106039172B - There is the Chinese medicine composition for improving memory function and its application containing centella - Google Patents
There is the Chinese medicine composition for improving memory function and its application containing centella Download PDFInfo
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- CN106039172B CN106039172B CN201610528132.0A CN201610528132A CN106039172B CN 106039172 B CN106039172 B CN 106039172B CN 201610528132 A CN201610528132 A CN 201610528132A CN 106039172 B CN106039172 B CN 106039172B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention adopts the following technical scheme: a kind of have the Chinese medicine composition for improving memory function and its application containing centella, it is characterised in that: formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=(10-30): (3-15): (3-60): (2-9): (1-15).The present invention, which has effects that improve, to be remembered, and therapeutic effect is good, and securely and reliably, without side-effects, using Chinese medicine, raw material is easy to get.
Description
Technical field
The present invention relates to field of medicaments, it is specially a kind of containing centella have improve memory function Chinese medicine compound prescription and
It is applied.
Technical background
Learning and memory is the advanced function of mankind's central nervous system, be brain it is most basic be also most important advanced mind
It is the important indicator for measuring human intelligence development through one of function.Memory is a kind of mental process, is people to living through, send out
The impression for the thing given birth to saves in the brain by processing, and extraction when needed, memory come out.Adult's memory is with the age
Increase and change, it is a kind of normal aging of memory that this, which is a kind of physiological variation,.
Decrease of memory, it is clinically especially the most common with 40~60 years old crowd.Its main risk factor has age increases
Greatly, the decline of body total quality, senile dementia early symptom, mental labour excessively etc..In addition to this, memory is also strong with body
Health situation is related, such as brain tumor, diabetes, alcoholism, hypothyroidism, nerve syphilis disease can all cause
Decrease of memory.Memory also has highly important relationship with mental health simultaneously, be chronically at social pressures are big, depression, feel oneself inferior,
Also it can cause memory disorders when the psychological conditions such as anxiety.
Distinguished veteran doctors of TCM expert by numerous studies find, failure of memory belong to Chinese medicine " amnesia ", " happiness is forgotten ", " forgetting " more,
The disease such as " forgetting well " scope, ancient prescription Chinese medicine think that forgetful and happiness is forgotten, be due to worrying beyond measure, nervous exhaustion, control and preferably nourish heart kidney.It is main
For " the mind residence of people depends on kidney in the heart, the essence of the heart ", and the brain being the house of mentality, the sea of marrow, real memory institute with.
In recent years the research influenced in relation to Chinese medicine and its extract on animal learning memory function is paid more and more attention, and experiment is ground
Study carefully and shows that Chinese medicine has its unique distinction to the decline for improving animal learning memory function.Using modem technology and method, from
There is the product for improving learning and memory function to have good prospect for exploitation in Chinese medicine.
Summary of the invention
The purpose of the present invention is to provide a kind of to have the Chinese medicine composition for improving memory function containing centella, controls
Therapeutic effect is good.
To achieve the above object, the present invention adopts the following technical scheme: a kind of having containing centella improves memory function
The Chinese medicine composition of energy, it is characterised in that formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: intelligence development
Benevolence: ginseng=(10-30): (3-15): (3-60): (2-9): (1-15).
Preferably, it is formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=
(10-20)∶(3-12)∶(3-30)∶(1-6)∶(1-6)。
Most preferably, it is formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng
=15: 6: 15: 3: 2.
The Chinese medicine composition is applied to the drug or health food of preparation improvement memory function.
The dosage form of the drug or health food is decoction, oral solution, syrup, capsule, tablet, granule or ball
Agent.
The drug or health food is added using the extract of component in the Traditional Chinese medicine composition formula as effective component
Add preparation made from pharmaceutic adjuvant.
The extract is water extract.
The present invention, which has effects that improve, to be remembered, and therapeutic effect is good, securely and reliably, without side-effects, using Chinese medicine, raw material
It is easy to get.
Specific embodiment
The present invention is a kind of Chinese medicine composition with improvement memory function containing centella, by following weight ratio
Medicine is formulated: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=(10-30): (3-15): (3-60): (2-9): (1-
15).Preferably, it is formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=(10-
20):(3-12):(3-30):(1-6):(1-6).Most preferably, it is formed by the traditional Chinese medicine of following weight ratio: centella: longan
Meat: oyster meat: fructus alpiniae oxyphyllae: ginseng=15: 6: 15: 3: 2.The Chinese medicine composition is applied to the drug of preparation improvement memory function
Or health food.
The drug or health food can be decoction.Alternatively, the convenience taken for patient and according to the characteristic of extract,
Preparation can be made, using the extract of component in the Traditional Chinese medicine composition formula as effective component, add corresponding pharmaceutic adjuvant, press
Any oral preparation is prepared into according to Chinese medicine conventional formulation technique.The dosage form of preparation can be oral solution, syrup, capsule
Agent, tablet, particle electuary, pill etc..Wherein extract is preferably water extract, can routinely extraction process by water preparation, such as: take
The medicinal material of formula is mixed according to monarch prescription ratio, every time with the water of 8~12 times of medicinal material deals, is heated to reflux and is mentioned after immersion
Take 1~3 hour, extract 1~3 time, filtering, merging filtrate, be concentrated to every 0.5~5.0g of milliliter contained to get.Again to extraction
Object, which adds corresponding pharmaceutic adjuvant, can be prepared into any oral preparation.
Chinese medicine used in the present invention has the feature that
Centella: for the drying herb of umbelliferae centella Centella asiatica (L.) Urb..It is bitter, pungent,
It is cold.With clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence effect is usually used in jaundice with damp-heat pathogen, heatstroke diarrhea, stone drenchs blood, and carbuncle sore tumefacting virus falls and flutters
Damage." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridian hectic fever is controlled, dizziness is cold, and limbs are aching and tired, distastes for food, and male woman child's infantile malnutrition due to digestive disturbances or intestinalparasites, deficient fever does not move back
Person with it, diuresis, buffalo meat be draw."
Arillus longan: for the aril of sapindaceous plant longan Dimocarpus longan Lour..With the help heart
The effect of spleen, nourishing blood and tranquilization.It is usually used in insufficiency of vital energy and blood, palpitation and severe palpitation, amnesia insomnia, blood deficiency chlorosis." book on Chinese herbal medicine is looked for the truth ": " longan
The sweet temperature of smell is similar to jujube more, but this sugariness is heavier, and profit gas is especially more, among tonifying Qi, and more has the power enriched blood, therefore book
The long intelligence of the beneficial spleen of energy is carried, nourishing heart protects blood, is heart spleen key medicine, is to see amnesia, palpitation, palpitation with fear and discharging fresh blood stool with thought internal lesion caused by overexertion, all
Can be controlled with this ".
Oyster meat: for long oyster Ostrea gigas Thunberg of Ostreidae animal, ostrea talienwhanensis Crosse Ostrea
The drying software part of talien whanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.Sweet, salty,
It is flat.Return liver, gallbladder, kidney channel.Function nourishing yin and nourishing blood.It has a sleepless night for dysphoria with smothery sensation, confused and worried, erysipelas.Supplement to the Herbal: cooking, main void
It damages, married woman's vim and vigour, in tune, solves erysipelas.It is eaten raw in ginger vinegar, and main erysipelas, dysphoria with smothery sensation, quenches the thirst after drinking.
Fructus alpiniae oxyphyllae: for the dry mature fruit of zingiberaceous plant intelligence development Alpinia oxyphylla Miq..Acrid flavour, it is warm-natured,
Enter the heart, spleen, kidney channel.Function warm kidney astringent sperm contracting urine, warming spleen and appetizing take the photograph saliva.It is cold to cure mainly spleen kidney deficiency, abdominal pain diarrhea；Or the kidney qi cold of insufficiency type is small
Just frequency, the enuresis, spermatorrhea, gonorrhoea；Or saliva is outflowed without the person of can control in chronic diarrhea caused by deficiency-cold in spleen and stomach and mouth.Intelligence development
Benevolence is containing volatile oil, fructus alpiniae oxyphyllae ketone, vitamin B1, vitamin B2, vitamin C, vitamin E and a variety of amino acid, fatty acid etc..Benefit
Intelligence benevolence decoction has the function of stomach invigorating, antidiuresis, reduces salivary secretion.Its water extract, which has, inhibits ascitogenous sarcoma S180 cell
The effect of growth.Its water extract and ethanol extract play the role of inhibiting ileum contraction.In addition, its methanolic extract has enhancing
Left atrium contracts power inhibits to exempt from the effects of aorta shrinks and inhibits the activity of prostaglandin synthetase caused by potassium chloride.
Ginseng: the dry root and rhizome of Araliaceae ginseng PanaxginsengC.A.Mey..Sweet, slight bitter, tepor.Return
Spleen, lung, the heart, kidney channel.Replenish vital energy, restore pulse, and strengthen and remove vital energy reinforces the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.It to be taken off for physically weak, limb cold
Weak pulse, spleen eating less, the deficiency syndrome of the lung are breathed with cough, injury thirst, Heat Diabetes, deficiency of qi and blood, prolonged illness virtual winning, insomnia of palpitating with fear, impotence palace cold.
" haigoushen ": " main the five internal organs unsaturated vapor, general debility is deficient thin and weak, spits inverse not lower food, only cholera unhappiness vomiting, tonifying five zang organs six
Internal organs keeps mind in guarantor." " disappears phlegm in the heart, main consumptive lung disease pyemesis and epilepsy disease, and cold air suffers from that people is empty and dreaminess is diverse and confused against upper, the not lower food of typhoid fever,
Add and uses it."
Take a broad view of full side, centella clearing heat and promoting diuresis, removing toxicity for detumescence；Oyster meat nourishing yin and nourishing blood.The two is monarch drug in a prescription altogether.The big benefit of ginseng
Vigour, shengjin nourishing, tranquilize the mind and promote the intelligence.For ministerial drug.Arillus longan tonifying heart and spleen, nourishing blood and tranquilization are adjutant；The contracting of fructus alpiniae oxyphyllae warm kidney controlling nocturnal emission with astringent drugs
Urine, it is to make medicine that warming spleen and appetizing, which takes the photograph saliva,.Heat-clearing enriching yin, blood-enriching tranquillizing effect are played altogether in full side.
Below with reference to embodiment, the present invention is further illustrated, but the present invention is not limited thereto specific examples:
Embodiment 1
Centella 150g, arillus longan 60g, oyster meat 150g, fructus alpiniae oxyphyllae 30g, ginseng 20g are taken, 10 times of amount water are added, impregnates 30
Minute, it refluxing extraction 1.5 hours, extracts 2 times, filtering, merging filtrate is concentrated into 250ml, obtains decoction.
Embodiment 2
Centella 300g, arillus longan 60g, oyster meat 30g, fructus alpiniae oxyphyllae 90g, ginseng 10g are taken, 10 times of amount water are added, impregnates 30
Minute, it refluxing extraction 1.5 hours, extracts 2 times, filtering, merging filtrate is concentrated into 250ml, obtains decoction.
Embodiment 3
Centella 150g, arillus longan 90g, oyster meat 200g, fructus alpiniae oxyphyllae 30g, ginseng 50g add 10 times of amount water, impregnate 45 points
Clock refluxing extraction 2 hours, extracts 3 times, and filtering, merging filtrate is concentrated into 250ml, obtains decoction.
Embodiment 4
1 gained decoction of above-described embodiment is taken, 10 times of amount water are added, agitating and heating is boiled, boiled 20 minutes, to be cooled to 30
At~40 DEG C, appropriate chitosan and potassium sorbate is added, be stirred to dissolve uniformly, filtering, finally plus pure water adjust to
1000ml is filtered, and packing sterilizes to get oral solution.Every oral solution 10ml.
Embodiment 5
Take 1 gained decoction of above-described embodiment, separately take sucrose 600g that simple syrup is made, to syrup temp be down to 60 DEG C hereinafter,
Be added 1 decoction of embodiment stirred evenly with ethyl hydroxy benzoate 0.lg, vanilla 2ml, filter, from filter add pure water adjust to
1000ml is mixed, and packing sterilizes to get syrup.Every 100ml.
Embodiment 6
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 25.8g is taken, fine powder is ground into, is added
Entering suitable medical starch and superfine silica gel powder, mix, crosses 14 meshes and pelletize, 65 DEG C of dryings carry out whole grain after 14 meshes,
Then suitable magnesium stearate is added, mixes, is pressed into 100 to get tablet.Every slice weight 0.45g.
Embodiment 7
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 14g is taken, fine powder is ground into, is added
Suitable medical starch and magnesium stearate are uniformly mixed, and sieving is packed into capsule, is made 100 to get hard capsule.Every intragranular holds
Object weight 0.25g.
Embodiment 8
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 25.6g is taken, fine powder is ground into, is added
Enter suitable dextrin and lactose, mix, granulation, 65 DEG C of dryings, cross 14 meshes carry out whole grain, packing, be made 100 packet to get
Granula.Every packet weight 4.5g.
Embodiment 9
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 26.8g is taken, fine powder is ground into,
Sieving mixes, and with water pill, is made 100 to get pill, every weight 1.45g.
Experimental example: improve the small experiment of memory function
1. experimental material
Kunming SPF grades male mice 78, weight 23-28g is provided by Nanfang Medical Univ's Experimental Animal Center.It is qualified
Card number: SCXK (Guangdong) 2011-0015.Test medicine carries out quantitative preparation using decoction prepared by embodiment 1.Morris water maze
Experimental system (including Morris water maze, computer camera system, software kit analysis system).
2. experimental method
2.1 groupings and administration
78 mouse are randomly divided into three groups, respectively high dose group, low dose group, blank group, every group 26；High dose
Group dosage is 14.90g/kg (crude drug amount/every kg animal weight), and low dose group dosage is 5.96g/kg (crude drug amount/every
Kg animal weight), it is administered in a manner of stomach-filling, once a day, continuous 22 days, blank group gave isometric physiological saline.
2.2Morris water maze laboratory
Morris water maze is divided into 4 quadrants, the sky blue platform that diameter is 10cm is placed in the fourth quadrant of pond, water
About 1 meter of pond diameter, the inside is equipped with ink, and the water surface is higher than platform 1-2cm.Camera is installed above pond and connects computer, from
Dynamic acquisition animal swimming trace image is simultaneously automatically analyzed and is handled, and record mouse finds the time (escape latency) of platform.If
Mouse does not find platform in 60s, then is led to platform and stop 10s, escape latency is denoted as 60s, Therapy lasted 6d time.
The average escape latency that every mouse enters water from four quadrants daily is calculated separately out, using its average value as small
The escape latency of this day of mouse, then blank group, low dose group are calculated respectively with excel, the daily escape of high dose group mouse is dived
The average value and variance of volt phase, is as a result indicated with x ± s, as shown in table 1.
Influence (x ± s, n=26) of 1 experimental drug of table to ability of learning and memory in mice
Note: * indicates significant difference (P < 0.05) compared to the blank group.
All in all by 1 result of table, the escape latency of each group mouse all shortens day by day, illustrates that mouse has study
The ability of memory；From first day to the 6th day, the escape plateau of each group mouse is essentially all blank group > low dose group > height
Dosage group, wherein third day plays high dose group significant difference compared with blank group, and drug of the present invention is prompted to have improvement to learn
The effect of memory capability, and high dose effect is more significant.
Claims (7)
1. a kind of have the Chinese medicine composition for improving memory function containing centella, it is characterised in that by following weight ratio
Medicine is formulated: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=(10-30): (3-15): (3-60): (2-9): (1-
15)。
2. according to claim 1 have the Chinese medicine composition for improving memory function containing centella, it is characterised in that
It is formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=(10-20): (3-12):
(3-30)∶(1-6)∶(1-6)。
3. according to claim 1 have the Chinese medicine composition for improving memory function containing centella, it is characterised in that
It is formed by the traditional Chinese medicine of following weight ratio: centella: arillus longan: oyster meat: fructus alpiniae oxyphyllae: ginseng=15: 6: 15: 3: 2.
4. drug or health care that Chinese medicine composition described in claim 1-3 any claim is applied to preparation improvement memory function
Food.
5. Chinese medicine composition is applied to the drug or health food of preparation improvement memory function according to claim 4, special
Sign is: the dosage form of the drug or health food is decoction, oral solution, syrup, capsule, tablet, granule or ball
Agent.
6. Chinese medicine composition is applied to the drug or health food of preparation improvement memory function according to claim 4, special
Sign is: the drug or health food is added using the extract of component in the Traditional Chinese medicine composition formula as effective component
Add preparation made from pharmaceutic adjuvant.
7. Chinese medicine composition is applied to the drug or health food of preparation improvement memory function according to claim 6, special
Sign is: the extract is water extract.
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| CN101473943A (en) * | 2008-12-12 | 2009-07-08 | 广西中医学院 | Health-care food for improving memory function and preparation method thereof |
| CN102423072A (en) * | 2011-11-24 | 2012-04-25 | 陕西方舟制药有限公司 | Health care food for improving memory and preparation method thereof |
| CN102861290A (en) * | 2012-09-10 | 2013-01-09 | 冯伟敏 | Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions |
| CN105267819A (en) * | 2015-07-17 | 2016-01-27 | 厦门医学高等专科学校 | Healthcare traditional Chinese medicine composition for relieving amnesia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101473943A (en) * | 2008-12-12 | 2009-07-08 | 广西中医学院 | Health-care food for improving memory function and preparation method thereof |
| CN102423072A (en) * | 2011-11-24 | 2012-04-25 | 陕西方舟制药有限公司 | Health care food for improving memory and preparation method thereof |
| CN102861290A (en) * | 2012-09-10 | 2013-01-09 | 冯伟敏 | Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions |
| CN105267819A (en) * | 2015-07-17 | 2016-01-27 | 厦门医学高等专科学校 | Healthcare traditional Chinese medicine composition for relieving amnesia and preparation method thereof |
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