CN102861290A - Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions - Google Patents
Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions Download PDFInfo
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- CN102861290A CN102861290A CN201210331789XA CN201210331789A CN102861290A CN 102861290 A CN102861290 A CN 102861290A CN 201210331789X A CN201210331789X A CN 201210331789XA CN 201210331789 A CN201210331789 A CN 201210331789A CN 102861290 A CN102861290 A CN 102861290A
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Abstract
The invention discloses a Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions. The Chinese medicinal preparation comprises the following bulk pharmaceuticals in parts by weight: 1 part of sharpleaf galangal fruit and 0.2-3 parts of turmeric. The Chinese medicinal preparation disclosed by the invention comprises Chinese medicines including sharpleaf galangal fruit, turmeric and the like. The sharpleaf galangal fruit and the turmeric can be used for prompting the medicament effect in a synergetic way, and a Chinese medicine method for regulating blood, reinforcing qi, reinforcing the kidney and increasing marrow is adopted, so that brain supply is improved, the brain function is strengthened, and reduction in the memory capability, thought capability and behavior capability caused by myelinopathy is improved remarkably. The invention provides a Chinese medicinal preparation which has a simple formula and a remarkable curative effect and is appropriate in cost for patients suffering from brain source dementia and disability.
Description
Technical field
The invention belongs to pharmaceutical technology, relate to a kind of Chinese medicine preparation with brain-tonifying effect, this Chinese medicine preparation is used for the improvement of degeneration, the decline of strain property intelligence.
Background technology
Degeneration and strain property cerebral lesion are the two large main causes that intelligence descends, along with the arrival of social senilization and the quickening of social life rhythm, the physical stress of brain increases increasingly, the risk that causes alba degeneration or the degeneration of strain property significantly rises, brain source property mistake intelligence, anergy patient in the mid-aged population particularly are on the increase, bring white elephant for society and patient family.
At present doctor trained in Western medicine to because of cerebral lesion to the treatment of losing intelligence, anergy patient, mainly in blood fat-reducing blood pressure-decreasing, blood vessel dilating, improvement circulation, promote metabolism and the neurokyme factor method such as induce to set about, but curative effect is totally not good enough, in treatment means comparatively significantly limitation is arranged.For this reason, the Chinese medicine researcher has proposed numerous Therapeutic Method according to theory of Chinese medical science, and many Chinese medicine preparation have been developed, but these preparations mostly are greatly the large prescription compages of cocktail type multi-flavor number, the targeting disappearance is comparatively obvious in determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the side's of entering Chinese medicine synergistic mechanism is unclear, and quality control and the increasing of cost control difficulty.Therefore, lead and look for that prescription is simple, determined curative effect, the suitable Chinese prescription of cost, be the target that relevant Chinese medicine researcher is pursued always.
The research that relevant cerebral function is degenerated, researcher has proposed numerous argumentations, wherein oxidative stress is said and is verified because of continuous studied experiment and to obtain the approval of most researcher, this argumentation has pointed out that the degradation mechanism of cerebral function and the Antioxidation Mechanism of body self have closely dependency, degeneration damage and strain property damage institute to degenerative that it has not only disclosed brain have interlinking in mechanism, more with the molecules aspect can be experimental, opened the observation window with excess syndrome meaning for the developmental research of related drugs.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation with brain-tonifying effect.
For addressing the above problem, the technical solution used in the present invention is:
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is: Fructus Alpiniae Oxyphyllae 1 weight portion, Rhizoma Curcumae Longae 0.2～3 weight portion.
Preferably, also added at least a in temperature compensation Chinese crude drug, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae in the crude drug of this Chinese medicine preparation.
Preferably, the temperature compensation Chinese crude drug is at least a in Radix Ginseng, the Radix Astragali.
Preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Ginseng is 1:0.2～3, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, the Radix Astragali is: 1:2.1～4.Further be preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Ginseng is 1:0.5～2, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, the Radix Astragali is: 1:2.5～3.5.
Preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae is 1:0.1～1, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Glycyrrhizae is 1:0.1～1.Further be preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae is 1:0.4～0.6, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Glycyrrhizae is 1:0.4～0.6.
Preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae is 1:0.5～2.
Preferably, the effective ingredient of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae respectively is the water extract of gained medicinal residues behind the alcohol steep thing of its medical material and the alcohol steep.
Preferably, the effective ingredient of Pericarpium Citri Reticulatae is the water extract of gained medicinal residues behind the alcohol steep thing of its medical material and the alcohol steep, and the effective ingredient of Radix Glycyrrhizae is the water extract of its medical material.
Preferably, the effective ingredient of Radix Ginseng is the water extract of gained medicinal residues behind its alcohol steep thing and the alcohol steep, and the effective ingredient of the Radix Astragali is the water extract of its medical material.
Preferably, the weight portion proportioning of the crude drug of this Chinese medicine preparation is: 1 part of Fructus Alpiniae Oxyphyllae, 0.5～2 part in Rhizoma Curcumae Longae, 0.5～2 part of Radix Ginseng, 2.5～3.5 parts of the Radixs Astragali, 0.4～0.6 part of Pericarpium Citri Reticulatae, 0.4～0.6 part in Radix Glycyrrhizae.Further be preferably, the weight portion proportioning of the crude drug of this Chinese medicine preparation is: 1 part of Fructus Alpiniae Oxyphyllae, 1.5 parts in Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, 3 parts of the Radixs Astragali, 0.5 part of Pericarpium Citri Reticulatae, 0.5 part in Radix Glycyrrhizae.
The invention has the beneficial effects as follows:
Chinese medicine preparation of the present invention comprises the Chinese medicines such as Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, utilize Fructus Alpiniae Oxyphyllae and the Rhizoma Curcumae Longae collaborative facilitation on drug effect, by the treating blood disorders QI invigorating, reinforce the kidney and be full of the tcm methods of marrow, improving brain supports, strengthen cerebral function, memory ability, ability of thinking and the behavioral competence that causes because of myelinopathy descended to improve significantly.Specifically, its endurance hypoxia-bearing capability to body has remarkable booster action, behavior cognitive competence to the dysmnesia model mice is significantly improved, and dysmnesia model mouse brain antioxidant is had obvious repair, can also obviously improve the body constitution of suffering from a deficiency of the kidney.The present invention is for brain originality is lost intelligence, the anergy patient provides a kind of Chinese medicine preparation simple, that curative effect is obvious, cost is suitable of filling a prescription.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment, but do not limit to so.
If no special instructions, described part is weight portion among the embodiment.
Embodiment 1
Take by weighing 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1 part in Rhizoma Curcumae Longae, pulverize, add 5 times of weight 75%(v/v) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; The slag of getting it filled adds 5 times of weight decoctings and boils secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling adds starch and granulates, and cold drying (below 70 ℃), enters dress and makes capsule.
Embodiment 2
Take by weighing 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts in Rhizoma Curcumae Longae, 2.5 parts of Radix Ginsengs, pulverize, add 3 times of weight 80%(v/v) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; The slag of getting it filled adds 4 times of weight decoctings and boils secondary, and each 1.5h filters, merging filtrate, and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling adds starch, dextrin is granulated, cold drying (below 70 ℃) adds the magnesium stearate tabletting again, makes tablet.
Embodiment 3
Take by weighing 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts in Rhizoma Curcumae Longae, 2.5 parts of the Radixs Astragali, pulverize; Add 8 times of weight 85%(v/v in Fructus Alpiniae Oxyphyllae, the Rhizoma Curcumae Longae) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; Medicinal residues, the Radix Astragali are mixed, adds 5 times of weight decoctings and boil secondary, each 1.5h, filtration, merging filtrate, and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling adds starch, dextrin is granulated, cold drying (below 70 ℃) adds the magnesium stearate tabletting again, makes tablet.
Embodiment 4
Take by weighing 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1 part in Rhizoma Curcumae Longae, 1 part of Radix Ginseng, 3 parts of the Radixs Astragali, pulverize; Add 6 times of weight 80%(v/v in Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, the Radix Ginseng) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; The slag of getting it filled merges the Radix Astragali, add 6 times of weight decoctings and boil secondary, each 1.5h, filtration, merging filtrate, and to be concentrated into relative density be 1.05～1.10(70 ℃) magma, merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, add starch, dextrin granulation, cold drying (below 70 ℃) adds the magnesium stearate tabletting again, makes tablet.
Embodiment 5
Take by weighing 3 parts of 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1 part in Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, Pericarpium Citri Reticulatae 0.5, the Radix Astragali, pulverize; Add 7 times of weight 75%(v/v in Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, Radix Ginseng, the Pericarpium Citri Reticulatae) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; The slag of getting it filled merges the Radix Astragali, adds 4 times of weight decoctings and boils secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling adds amylodextrin and flavoring agent and granulates cold drying (below 70 ℃), granulation agent.
Embodiment 6
Take by weighing 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts in Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, 2.5 parts of the Radixs Astragali, 0.5 part in Radix Glycyrrhizae, pulverize; Add 4 times of weight 95%(v/v in Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, the Radix Ginseng) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05-1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; Add 6 times of weight decoctings in medicinal residues, the Radix Astragali, the Radix Glycyrrhizae and boil secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling adds amylodextrin and flavoring agent and granulates cold drying (below 70 ℃), granulation agent.
Embodiment 7
Take by weighing 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts in Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, Pericarpium Citri Reticulatae 0.5,3.0 parts of the Radixs Astragali, 0.5 part in Radix Glycyrrhizae, pulverize; Add 5 times of weight 85%(v/v in Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, Radix Ginseng, the Pericarpium Citri Reticulatae) alcohol steep 12h, the isolated by filtration medicinal residues, the negative pressure Recycled ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma for subsequent use; The slag of getting it filled merges the Radix Astragali, Radix Glycyrrhizae, add 5 times of weight decoctings and boil secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma, merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, add amylodextrin and flavoring agent and granulate cold drying (below 70 ℃), granulation agent.
Embodiment 8
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.5 part of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.Its preparation method is with embodiment 1, and is lower same.
Embodiment 9
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 2 parts of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.
Embodiment 10
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.2 part of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.
Embodiment 11
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 3 parts of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.
Embodiment 12
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.4 part of 1 part of Fructus Alpiniae Oxyphyllae, 2 parts in Rhizoma Curcumae Longae, 0.5 part of Radix Ginseng, 3.5 parts of the Radixs Astragali, 0.6 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Embodiment 13
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.6 part of 1 part of Fructus Alpiniae Oxyphyllae, 0.5 part in Rhizoma Curcumae Longae, 2 parts of Radix Ginsengs, 2.5 parts of the Radixs Astragali, 0.4 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Embodiment 14
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.6 part of 1 part of Fructus Alpiniae Oxyphyllae, 0.5 part in Rhizoma Curcumae Longae, 2 parts of Radix Ginsengs, 2.5 parts of the Radixs Astragali, 0.4 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Embodiment 15
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 1 part of 1 part of Fructus Alpiniae Oxyphyllae, 1.5 parts in Rhizoma Curcumae Longae, 3 parts of Radix Ginsengs, 2.1 parts of the Radixs Astragali, 0.1 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Embodiment 16
A kind of Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.1 part of 1 part of Fructus Alpiniae Oxyphyllae, 3 parts in Rhizoma Curcumae Longae, 0.2 part of Radix Ginseng, 4 parts of the Radixs Astragali, 1 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Chinese medicine preparation of the present invention has been followed traditional tcm theory at prescription compatibility and processing technology, and by modern pharmacodynamics method checking is made in its safety and effectiveness.
The acute toxicity test of Chinese medicine preparation of the present invention is observed:
To add water by the concentrated extract (4.0g crude drug/1g extractum) of embodiment 7 preparations and be made into the 0.7g/ml suspension, (body weight 22 ± 2g) is pressed the 80ml/kg gastric infusion to give the kunming mice of hungry 16h, gradation is finished in 20 minutes, observe the movable minimizing of mice after the administration in 30 minutes, the movable recovery normally behind the 1h, administration in continuous 7 days occurs without death, because being subject to administration volume and liquor strength, test fails to measure the LD50 value of said preparation, but the maximum tolerated dose that experiment shows said preparation is equivalent to 224g crude drug/kg) greater than 56g extractum/kg(, is 800 times of Clinical design dosage (maximum tolerated doses * per capita body weight ÷ Clinical design dosage).The result shows, the safety of said preparation clinical practice tool.
The long term toxicity test of Chinese medicine preparation of the present invention is observed:
Be equivalent to 11.2g crude drug/kg) by the concentrated extract 2.8g(of the dosis tolerata 1/20 of maximum, be SD rat gastric infusion every day 1 time of 180 ± 20g, male and female half and half to body weight, successive administration 90 days, observe administration on rat diet, drainage, body weight change and active situation without impact, routine blood test, liver function test are without unusually, the viscera organ pathology cuts into slices without unusual, and the result shows, the safety of said preparation long-term taking tool.
The endurance hypoxia endurance test of Chinese medicine preparation of the present invention is observed:
Animal: 70 of kunming mices, male and female half and half, body weight 22 ± 2g, following test mice requires all identical.
Tested mice is divided into the blank group, Chinese medicine preparation high dose group of the present invention, Chinese medicine preparation low dose group of the present invention, model control group, except the blank group, all the other each groups were established as the Mouse Kidney virtual model in 28 days by the administration of 0.2mg/10gd dexamethasone subcutaneous injection, after dexamethasone is administered to the 14th day, from the 15th day, use simultaneously embodiment 1, the concentrated extract of embodiment 7 preparations is respectively to administration group gastric infusion, the high dose group of dosage: embodiment 1 group is pressed 60mg/kgd, low dose group is pressed the dosage of 40mg/kgd, the high dose group of embodiment 7 groups is pressed 80mg/kgd, low dose group is pressed the dosage of 50mg/kgd, gastric infusion is 14 days continuously, and 1 hour begins to test after the last administration.
1. the time test is adhered in swimming:
It is that 12cm, water temperature are 25 ℃ glass cistern that tested mice is put into the depth of water, is as the criterion with respiratory arrest, the death time of record mice, the results are shown in Table 1.
2. closed chamber is adhered to the time test:
Tested mice is put into the airtight wide mouthed bottle of little volume that fills the 15g sodica calx, be as the criterion with respiratory arrest, the death time of record mice, the results are shown in Table 2.
By table 1 and table 2 as can be known, taking the mice endurance of Chinese medicine preparation of the present invention, the time of anoxia enduring obviously increases, and is positive-effect with dosage, and as seen this Chinese medicine preparation improves significantly to the physical condition of the mice of suffering from a deficiency of the kidney.And the prescription of selecting temperature compensation Chinese crude drug compatibility (embodiment 7) in the herbal pharmaceutical agent of the present invention to tested mice fatigue resistance to improve effect more obvious.
Chinese medicine preparation of the present invention is to improving amnemonic experimental observation:
Animal: 96 of kunming mices, male and female half and half, body weight 22 ± 2g.Following test mice requires all identical.
Tested mice is divided into blank group, Chinese medicine preparation high dose group of the present invention, Chinese medicine preparation low dose group of the present invention, model control group, except blank group, model control group not, the concentrated extract difference gastric infusion that all the other two administration groups prepare with embodiment 1, embodiment 7, the high dose group of dosage: embodiment 1 group is pressed the dosage that 60mg/kg. d, low dose group press 40mg/kg. d, the high dose group of embodiment 7 groups is pressed the dosage that 80mg/kg. d, low dose group press 50mg/kg. d, and gastric infusion is 14 days continuously.Test after 1 hour after the last administration.
1. the observation that mouse memory acquired disturbance model is affected:
After the last administration after 1 hour, by model control group and the tested mice of two administration groups are established as mouse memory acquired disturbance model group by the dosage lumbar injection scopolamine 5mg/kg of 10ml/KG, behind the administration 30min, organize tested mice together with blank, put on the electricity irritation test reflective box valve rubber of 12 * 12 * 18cm, connect the 50v alternating current, carry out electricity irritation reflection step down test training 5min, test mice first jumps off the incubation period of valve rubber and the errors number in the 5min after 24 hours.Test data carries out statistical disposition with statistical package PEMS data base.The results are shown in Table 3.
As shown in Table 3, Chinese medicine preparation of the present invention has obvious repair to tested mouse memory acquired disturbance, and is positive-effect with dosage.
2. mouse memory being reproduced the Disorder Model impact observes:
After the last administration after 1 hour, such as front method tested mice is carried out step down test training 5min, carry out the test of electricity irritation test reflective box such as front method after 24 hours, 30min before the test, by giving 30% medical ethanol to model control group and two administration group mices by the dosage gavage of 10ml/KG, be established as mouse memory and reproduce the Disorder Model group, organize tested mice together with blank afterwards, put into electricity irritation test reflective box and test, test mice first jumps off the incubation period of valve rubber and the errors number in the 5min.The same method of test data statistical processing methods.The results are shown in Table 4,
As shown in Table 4, Chinese medicine preparation of the present invention reproduces obstacle to tested mouse memory obvious repair, and is positive-effect with dosage.
Chinese medicine preparation of the present invention and single raw material pharmacodynamics contrast test are observed:
Animal: 40 of kunming mices, male and female half and half, body weight 22 ± 2g, following test mice requires all identical.
Medicine: preparation method all prepares the method for concentrated extract by embodiment 1, and embodiment 1 concentrated extract is made by 1 part of Fructus Alpiniae Oxyphyllae, 1 portion of Rhizoma Curcumae Longae; The Fructus Alpiniae Oxyphyllae concentrated extract is made by 2 parts of Fructus Alpiniae Oxyphyllae; 2 portions of Rhizoma Curcumae Longaes of Rhizoma Curcumae Longae concentrated extract make.The concentrated extract active ingredient is the suitable 4.0g crude drug of 1g extractum.
Tested mice is divided into blank group, 1 group of embodiment, Fructus Alpiniae Oxyphyllae group, Rhizoma Curcumae Longae group, model control group, except the blank group, all the other each groups were established as the degeneration dysmnesia model in 42 days by the administration of D-galactose 50mg/Kgd subcutaneous injection, wherein 1 group of embodiment, Fructus Alpiniae Oxyphyllae group, Rhizoma Curcumae Longae are organized from D-galactose administration the 1st day, simultaneously with concentrated extract gastric infusion corresponding to each group, dosage is all by 60mg/kgd, be administered to the 42nd day, 1 hour beginning behavior test after the last administration.
1. impact is observed on mice degeneration dysmnesia model:
Organize tested mice together with blank and put into electricity irritation test reflective box and test, process is the same.The results are shown in Table 5.
As shown in Table 5, after the present invention adds Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae combination simultaneously, the improvement effect of the behavior cognitive competence of degeneration dysmnesia model mice is greater than the effect of independent interpolation Fructus Alpiniae Oxyphyllae or Rhizoma Curcumae Longae, as seen, in the Chinese medicine preparation of the present invention, Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae have collaborative facilitation, can significantly improve the amnemonic repair of mice degeneration.
2. mice degeneration dysmnesia model brain biochemical is observed:
After the above-mentioned behavior off-test, the tested mice of sacrificed by decapitation immediately, sharp separation bilateral hippocampus under the low temperature, accurately weigh, and add by weight normal saline and make 10% brain tissue homogenate, getting supernatant after centrifugal carries out biochemical test, test mouse brain SOD vigor and MDA content, method of testing is undertaken by SOD, MDA test kit description, and test data carries out statistical disposition with statistical package PEMS data base.The results are shown in Table 6.
By table 6 also as can be known, after the present invention adds Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae combination simultaneously, the effect of the reduction of the raising of degeneration dysmnesia model mouse brain SOD vigor and MDA content is greater than the effect of independent interpolation Fructus Alpiniae Oxyphyllae or Rhizoma Curcumae Longae, and effect is almost near the level (blank group) of normal mouse after adding simultaneously the combination of Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae, as seen, in the Chinese medicine preparation of the present invention, Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae have collaborative facilitation, can significantly promote the raising of degeneration dysmnesia model mouse brain SOD vigor and the reduction of MDA content.
Above-mentioned results of pharmacodynamic test demonstration, Chinese medicine preparation of the present invention improves significantly to the physical condition of the mice of suffering from a deficiency of the kidney; Tested mice endurance, hypoxia-bearing capability all there are obvious booster action and are positive-effect with dosage; Tested mouse memory acquired disturbance and memory represents obstacle all there are obvious repair, and are positive-effect with dosage.The result also shows, the compatibility raw material of the Chinese medicine preparation of the present invention that is comprised of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae has drug effect to work in coordination with facilitation, behavior cognitive competence and brain antioxidant to degeneration dysmnesia model mice all improve significantly, result of the test comprehensively shows, Chinese medicine preparation of the present invention has the reinforcement cerebral function, improves the effect of memory ability, ability of thinking and behavioral competence.
Claims (10)
1. Chinese medicine preparation with brain-tonifying effect, its crude drug is: Fructus Alpiniae Oxyphyllae 1 weight portion, Rhizoma Curcumae Longae 0.2～3 weight portion.
2. Chinese medicine preparation according to claim 1 is characterized in that: also added at least a in temperature compensation Chinese crude drug, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae in the crude drug.
3. Chinese medicine preparation according to claim 2 is characterized in that: the temperature compensation Chinese crude drug is at least a in Radix Ginseng, the Radix Astragali.
4. Chinese medicine preparation according to claim 3, it is characterized in that: the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Ginseng is 1:0.2～3, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, the Radix Astragali is: 1:2.1～4.
5. Chinese medicine preparation according to claim 2, it is characterized in that: the weight proportion of Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae is 1:0.1～1, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Glycyrrhizae is 1:0.1～1.
6. each described Chinese medicine preparation according to claim 1～5, it is characterized in that: the weight proportion of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae is 1:0.5～2.
7. each described Chinese medicine preparation according to claim 1～5 is characterized in that: the effective ingredient of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae respectively is the water extract of gained medicinal residues behind the alcohol steep thing of its medical material and the alcohol steep.
8. each described Chinese medicine preparation according to claim 2～5 is characterized in that: the effective ingredient of Pericarpium Citri Reticulatae for the alcohol steep thing of its medical material and alcohol steep after the water extract of gained medicinal residues, the effective ingredient of Radix Glycyrrhizae is the water extract of its medical material.
9. according to claim 3 or 4 described Chinese medicine preparation, it is characterized in that: the effective ingredient of Radix Ginseng for its alcohol steep thing and alcohol steep after the water extract of gained medicinal residues, the effective ingredient of the Radix Astragali is the water extract of its medical material.
10. Chinese medicine preparation according to claim 6, it is characterized in that: the weight portion proportioning of the crude drug of this Chinese medicine preparation is: 1 part of Fructus Alpiniae Oxyphyllae, 0.5～2 part in Rhizoma Curcumae Longae, 0.5～2 part of Radix Ginseng, 2.5～3.5 parts of the Radixs Astragali, 0.4～0.6 part of Pericarpium Citri Reticulatae, 0.4～0.6 part in Radix Glycyrrhizae.
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| CN104041813A (en) * | 2014-06-17 | 2014-09-17 | 史克勇 | Formula of health food capable of improving memory |
| CN106039172A (en) * | 2016-07-06 | 2016-10-26 | 南方医科大学 | Traditional Chinese medicine composition containing centella asiatica and capable of improving memory function and application of traditional Chinese medicine composition |
| CN110694035A (en) * | 2019-11-23 | 2020-01-17 | 卢逊 | Oral Chinese medicinal composition and its preparation method |
| CN112402554A (en) * | 2020-10-26 | 2021-02-26 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for treating leukoencephalopathy and application thereof |
| CN114098085A (en) * | 2021-12-06 | 2022-03-01 | 中国医科大学 | Functional food composition with auxiliary memory improving function and application |
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