CN101473943B - Health-care food for improving memory function and preparation method thereof - Google Patents
Health-care food for improving memory function and preparation method thereof Download PDFInfo
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- CN101473943B CN101473943B CN2008100739747A CN200810073974A CN101473943B CN 101473943 B CN101473943 B CN 101473943B CN 2008100739747 A CN2008100739747 A CN 2008100739747A CN 200810073974 A CN200810073974 A CN 200810073974A CN 101473943 B CN101473943 B CN 101473943B
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Abstract
The invention relates to a healthy food with the function of improving memory and a preparation method thereof. The healthy food is made from fiveleaf gynostemma herb, pseudo ginseng root, ginseng, epimedium, bitter cardamom and mulberry seed. The healthy food can be made into granules or other oral solid preparations, has the healthy function of improving the memory and has the effects of prevention, health protection and auxiliary treatment towards people with study and memory dysfunction and people with senile dementia and hypomnesis. The product is safe and reliable for using and has no toxic or side effects.
Description
Technical field:
The present invention relates to a kind of health food, particularly improve health food of memory function and preparation method thereof.
Background technology:
Along with the quickening of modern society study work rhythm of life, people have in the face of the pressure from each side, and increasing people is just receiving the go down puzzlement of encephalasthenia of ability of learning and memory.Be the best prevention and health care period of carrying out medicine and behavior intervention at this moment, otherwise in the past for a long time, then might cause the generation of senile dementia.
Along with the world population aging; The senile dementia incidence of disease rises year by year; Become the fourth-largest disease that causes that after tumour, heart disease, headstroke the elderly is dead, so anti-ageing year dementia medicine of research and development become the medical problem that the whole world presses for solution.And China aged sharply increases, and it is particularly outstanding that this problem also seems.In the face of the challenge of aging population, provide for a rainy day, go into overdrive; Carry out research in a deep going way, excavate the advantage of traditional Chinese medicine, seek definite effective and prevent and treat method the senile dementia control; Improve senile dementia patient learning and memory function; To life quality that improves the patient and the ability that adapts to society,, crucial meaning is arranged all at utmost to reduce the adverse consequences that dull-witted type disease is brought.
Therefore, press for that exploitation is a kind of to have the health food of functions of prevention and health care to damage in learning and memory crowd and senile dementia failure of memory crowd, significant.
Summary of the invention:
The present invention is a kind of health food that improves memory function and preparation method thereof, and its purposes is: provide a kind of damage in learning and memory crowd and senile dementia failure of memory crowd are had the health food of functions of prevention and health care and its preparation method.
Health food of the present invention is to be processed by following weight portion Chinese medicine material:
Gynostemma pentaphylla 5-30 barrenwort 5-15
Pseudo-ginseng 5-20 fructus alpiniae oxyphyllae 5-15
Genseng 5-15 mulberry fruit 5-20.
Use above-mentioned raw materials, be equipped with suitable auxiliary material and can be made into granule or other oral solid formulation.
The preparation method of health food of the present invention may further comprise the steps:
1) with the genseng crushed after being dried, cross the 80-200 mesh sieve, subsequent use;
2) gynostemma pentaphylla, pseudo-ginseng, barrenwort, fructus alpiniae oxyphyllae, mulberry fruit was soaked 1-3 hour, reflux 2-4 time, each 1-4 hour, to filter while hot, filtrating merges, and is evaporated to the medicinal extract that density is 1.2-1.3, and is subsequent use;
3) by 2) step gained medicinal extract and genseng fine powder mixing, and press formulation method and add right amount of auxiliary materials, process corresponding oral solid formulation, packing promptly gets.
Health food of the present invention has the health care that improves memory, and damage in learning and memory crowd and senile dementia failure of memory crowd are had prevention and health care and supplemental treatment effect.Chinese medicine of the present invention truly has the effect of improving memory through clinical confirmation for many years.The inventor has also carried out toxicology test, function assessment test to granule, and its result also confirms to have the memory impairments of improvement, and safe these article of toxicological test confirmation are taken safety for a long time.Because for Chinese medicine preparation (being the integration of drinking and medicinal herbs medicine), action temperature with, side effect is little, can take for a long time, to failure of memory crowds such as senile dementias, prevention and treatment double action is arranged.
Below be the experimental data of function and effect:
One, granule function assessment animal test results of the present invention
1. dosage
Everyone (by the 60kg batheroom scale) recommended intake every day is granule 20g (being equivalent to crude drug 15g).Being converted into every day kg body weight dosage is 0.334g/kg, presses 5 times of human body recommended intakes, 10 times, 25 times basic, normal, high 3 dose groups of design respectively, promptly 1.66,3.34, and 8.30g/kg.
2. improve the effect of memory
Test basis: according to ((health food check and assessment technique standard " (version in 2003) carry out.
2.1 step down test
[purpose] observed the effect that granule of the present invention improves learning and memory.
[method] got 72 of cleaning level Kunming kind female mices; Body weight 20g ± 2g; After adaptability fed for 1 week; Be divided into 6 groups at random, promptly blank control group, model group, piracetam group (0.5gkg-1d-1) and granule high (8.30gkg-1d-1), in (3.34gkg-1d-1), low (1.66gkg-1d-1) dose groups.Gastric infusion, administration volume are 0.2ml/10g.Blank control group, model group are given distilled water (with the drug group co-content).Administration every day 1 time, successive administration 30 days, the experiment of mouse diving tower is carried out in modeling in 1 hour after the last administration, observes medicine to memory dysfunction improvement effect.Except that the blank group, (the memory acquisition disturbance model is made: 10min scopolamine hydrobromide 2mg/kg body weight before the training in all the other 5 groups whole lumbar injection modelings; The manufacturing of obstacle model is consolidated in memory: 10min lumbar injection cycloheximide 120mg/kg body weight before the training), observe the influence of particle of the present invention to the mouse memory obstacle, the result sees table 1.
[result] is visible by table 1, and each group all compares with model group, memory acquisition phase errors number: piracetam group P＜0.05, and all the other respectively organize equal P＜0.01, and difference has statistical significance; Memory obtains incubation period, memory is consolidated incubation period: blank control group, middle dosage P＜0.05, difference has statistical significance.Presentation of results modeling success and each administration group all have the improvement effect (if given the test agent group mouse and model group are relatively to memory dysfunction; Obviously prolong incubation period; Errors number obviously reduces, and difference has statistical significance, in above each item index; Each index in arbitrary stage is positive, and all this experiment of decidable is positive).Point out the granule of the present invention learning and memory effect that has some improvement.
Table 1 learning and memory of little mouse (x ± s)
Represent that with model group comparison * P＜0.05 * * representes P＜0.01
2.2 water maze test
[purpose] observed the effect that granule improves learning and memory.
[method] got 48 of cleaning level SD female rats, and body weight 180～220g, after adaptability fed for 1 week, is divided into 4 groups, i.e. the high, medium and low dose groups of blank control group and granule at random by 12 every group.Gastric infusion, administration volume are 1ml/100g.Blank control group (with the drug group co-content).Administration every day 1 time, successive administration 30 days, last are given a kind next day and are begun training.Training period continues to appearance, and once a day, the result sees table 2.
[result] is visible by table 2, and high, medium and low dose groups of granule and blank control group be P＜0.05 or P＜0.01 relatively, and difference has statistical significance, explains that granule various dose group all has improvement effect in various degree to the learning and memory of rat.
Table 2 learning and memory in rats achievement (x ± s)
Represent that with model group comparison * P＜0.05 * * representes P＜0.01
3. the mechanism of action
3.1 granule of the present invention is to the influence of adult mice brain protein content and brain monoamine oxidase (MAO)
[purpose] inquired into granule maybe the mechanism of action.
[principle] cerebral cortex is the material base of learning and Memory, and in the process of learning and memory, the synthetic increase of brain internal protein stores through the experience that new synthetic protein will newly obtain.Brain protein SYNUCLEINS and nucleotide level are brain aging degree and the strong and weak material base of learning and memory; MAO is the enzyme of catalyze aromatic, aliphatic monoamine oxidative deamination radical reaction widely, is divided into A, B amphitypy, and it is with old and feeble closely related.Most results of study show that human brain MAO-B is active relevant with the age, and promptly its activity sharply increased with age growth after 45 years old.That is to say the aging along with body, brain MAO-B is active constantly to rise.Along with the active continuous rising of MAO-B; The brain monoamine can neural regulating action descend day by day; Cause the imbalance that neuroendocrine is regulated; The symptom of degeneration central nervous system disease such as Parkinson's disease appears in the degeneration, the abnormal behavior that not only cause the brain physiological function, but also causes that whole machine body is progressively old and feeble.
48 of [method] 12 monthly age kunming mices, male and female half and half, body weight 50 ± 5g is divided into 4 groups at random, 12 every group: the blank group, the granule high dose, in, low dose group.The administration capacity: every treated animal is pressed 0.2ml/10g, the ig administration.Blank control group gives equal-volume physiological saline; The administration group gives respectively: high dose group 8.30gkg-1d-1, middle dosage 3.34gkg-1d-1, low dosage 1.66gkg-1d-1 (more than be the crude drug amount); Successive administration 30d; Behind the last administration 1h; All disconnected neck is put to death animal, gets the full brain of mouse on the ice pan fast, is used for the mensuration of MAO activity and brain tissue protein content.(the active mensuration of MAO-B is undertaken by the kit explanation; The brain tissue protein content determination is explained by kit (Coomassie brilliant blue method) and is carried out
[result] is visible by table 3, and high, medium and low dose groups of particle and blank control group comparison brain protein content and activity of monoamine oxidase difference have conspicuousness (the P value is all less than 0.05).Can think has the rising effect to aged mouse brain tissue protein content, and monoamine oxidase in the brain (MAO-B) activity is had the reduction effect.(the P value is all greater than 0.05).
Table 3 is respectively organized relatively (x ± s) of aged mouse brain tissue protein content and activity of monoamine oxidase
* represent P＜0.05
3.2 granule of the present invention is to the active influence of hippocampus of adult rat AchE
[meaning] hippocampus is the major function district of brain learning memory; Acetylcholine participation in learning memory activity; Hippocampus acetyl choline content height can reflect the power of ability of learning and memory; Acetylcholinesterase (TChE) can make the acetylcholine hydrolyzation inactivation, thus medicine active intervention is its one of mechanism of memory that interferes with one's studies to TChE.
[method] got 48 of cleaning level SD female rats, body weight 180～220g, 12 every group, after adaptability fed for 1 week, be divided into 4 groups at random, promptly blank control group and granule height, in,, low, dose groups.Gastric infusion, administration volume are 1ml/100g.Blank control group (with the drug group co-content).Administration every day 1 time; High dose group 8.30gkg-1d-1, middle dosage 3.34gkg-1d-1, low dosage 1.66gkg-1d-1 (more than be the crude drug amount), successive administration 30d; Behind the last administration 1h, all disconnected neck is put to death animal, gets the full brain of mouse on the ice pan fast; Anatomical lens separates hippocampus down, and it is active to measure hippocampal tissue TChE.Sample process and TChE determination of activity are undertaken by the explanation of kit separately requirement.
[result] each group is all relatively seen table 4 with blank group (physiological saline group); Each organizes P＜0.01; Difference has statistical significance; The result shows that granule of the present invention possibly be active through reducing the rat hippocampus tissue acetylcholinesterase, raises acetyl choline content indirectly and improves the rat memory, and this possibly be that it improves one of mechanism of learning and memory.
Table 4 rat hippocampus acetylcholinesterase vitality index table (x ± s)
Represent that with physiological saline group comparison * P＜0.05 * * representes P＜0.01
To sum up, zoopery shows that particle of the present invention all has the effect of obvious promotion learning and memory function to the large and small mouse that grows up.Point out particle of the present invention that the effect that improves memory is arranged.Its effect is by way of being many-sided: can increase aged mouse brain tissue protein content and reduce activity of monoamine oxidase, also can reduce the rat hippocampus acetylcholine esterase active, improve memory impairments thereby reach.This has also embodied the characteristics of the many target spots of Chinese medicine effect, multipath and multisystem.
Two, safe toxicological test
Test basis: carry out according to " health food check and assessment technique standard " (version in 2003).Experiment is with cleaning level Kunming mouse and cleaning level WISTAR rat.
1. 30 days feeding trials of rat
Assay and evaluation: WISTAR kind healthy rat contained the pellet of 0.50,1.00,2.00% sample every day, dosage is 8.35,16.70; 33.4g/kg, be equivalent to 25,50 of human body recommended amounts; 100 times, test period totally 30 days, result of the test is:
1) the general physiology sign of rat, behavior, stool and urine, fur etc. are all no abnormal.
2) body weight and food utilization index are normal
3) the blood routine index is normal
4) biochemical indicator is no abnormal
5) each organ coefficient index is normal
6) inspection substantially of organs such as each rat heart, liver,spleen,kidney, small intestine, emerald green ball is no abnormal;
The liver of control group and high dose group rat, kidney and the pathological observation result of small intestine are basic identical, do not see special pathological change.
2. its mouse oral acute toxicity test (LD50)
Male, female mice per os LD50＞30g/kg are tried thing particle of the present invention and are belonged to nontoxic level material.
3. mouse bone marrow cells micronucleus test
1.50 the micronucleus result of～10.0g/kg dosage is negative, is tried thing particle of the present invention body cell is not had mutagenesis.
4. mouse sperm deformity test
The spermatic aberration test result of 50～10.0g/kg dosage is negative, is tried thing particle of the present invention reproduction cell is not had mutagenesis.
5.Ames test
8-5000 μ g/ ware is tried thing to salmonella typhimurium strain TA97; TA98, TA1000, TA102 carries out the plate infiltration test; No matter when adding and do not add the S9 mixed liquor; Each dose groups does not cause that all the back mutation bacterium colony of test strain significantly increases, and the Salmonella reversion test result is negative, is tried thing particle of the present invention and does not have direct or indirect mutagenesis.
Above presentation of results, particle of the present invention does not have obvious toxic and side effects.
Three, granule is to improving the clinical efficacy of human body memory
1. research object
The elderly more than 40 years old suffers from dissimilar and failure of memory property disease degree.
2. method of administration
The adult, each 10g, every day 2 times.
Above research object was a course of treatment with one month all, treated 1-3 the course of treatment.
3. observational technique:
1) general situation: comprise spirit, sleep, diet, stool and urine, heart rate etc. (children only require and carry out general physical examination such as cardiopulmonary auscultation, liver palpation of spleen)
2) blood, routine urianlysis
3) liver, kidney function test (children experimenter does not measure this)
4) blood, urine, just routine test and the heart, pulmonary function test, liver, kidney function test are carried out in Chest X-rays, electrocardiogram, Abdominal B type ultrasonography inspection (the adult experimenter measures this and only pretest inspection is once).
5) effect index: use the Clinical Memory scale.The original branch of each subtest with after the test is looked into scale score, and each subtest scale score addition gets total scale score, looks into memory quotient with total scale score.
Observe 319 routine middle-older patients altogether, its clinical effectiveness is seen table 5:
Table 5 particle improves the clinical observation on the therapeutic effect of memory
Side effect of the present invention: outside the period in a medicine small number of patients dry, all do not have any bad reaction, stop using or decrement the dry transference cure.
Clinical research shows that particle of the present invention is obvious to improving middle-aged and old memory effects, and toxic and side effect is little.
The specific embodiment:
Embodiment 1: the method for making of powder
Get parts by weight of raw materials (gram or kilogram):
Gynostemma pentaphylla 5 barrenwort 5
Pseudo-ginseng 5 fructus alpiniae oxyphyllaes 5
Genseng 5 mulberry fruits 5
With the genseng crushed after being dried, cross 80 mesh sieves, subsequent use; Gynostemma pentaphylla, pseudo-ginseng, barrenwort, fructus alpiniae oxyphyllae, mulberry fruit was soaked 1 hour; Reflux 2 times, each 1 hour, to filter, filtrating merges, and is concentrated into the medicinal extract that density is 1.2-1.3; With genseng fine powder mixing, drying gets dry extract, and after dried cream powder is broken, processes powder behind the adding auxiliary material commonly used, and packing promptly gets.
The method for making of embodiment 2. tablets
Get parts by weight of raw materials (gram or kilogram):
Gynostemma pentaphylla 30 barrenwort 15
Pseudo-ginseng 20 fructus alpiniae oxyphyllaes 15
Genseng 15 mulberry fruits 20
With the genseng crushed after being dried, cross 200 mesh sieves, subsequent use; Gynostemma pentaphylla, pseudo-ginseng, barrenwort, fructus alpiniae oxyphyllae, mulberry fruit; Soaked 3 hours, reflux 4 times each 4 hours, is filtered; Filtrating merges, and is concentrated into the medicinal extract that density is 1.2-1.3, and with genseng fine powder mixing, drying gets dry extract; After dried cream powder is broken, mixing granulation behind the adding auxiliary material commonly used, compressing tablet, packing promptly gets.
The method for making of embodiment 3. granules
Get parts by weight of raw materials (gram or kilogram):
Gynostemma pentaphylla 20 barrenwort 9
Pseudo-ginseng 10 fructus alpiniae oxyphyllaes 9
Genseng 9 mulberry fruits 18
With the genseng crushed after being dried, cross 100 mesh sieves, subsequent use; Gynostemma pentaphylla, pseudo-ginseng, barrenwort, fructus alpiniae oxyphyllae, mulberry fruit was soaked 2 hours; Reflux 3 times, each 2 hours, to filter, filtrating merges, and is concentrated into the medicinal extract that density is 1.2-1.3, with genseng fine powder mixing; Add right amount of auxiliary materials, mixing, wet granulation, oven dry, whole grain, packing promptly gets.
Above embodiment and experimental example just illustrate of the present invention, and purpose is to illustrate implementation method of the present invention, and those skilled in the art in conjunction with the various changes that the general knowledge of this area is done, will fall into the protection domain of invention according to enlightenment of the present invention.
Claims (3)
1. health food that improves memory function is characterized in that: process the health food raw materials of effective components and form and be by weight:
Gynostemma pentaphylla 5～30 barrenwort 5～15
Pseudo-ginseng 5～20 fructus alpiniae oxyphyllaes 5～15
Genseng 5-15 mulberry fruit 5～20.
2. the health food that improves memory function according to claim 1 is characterized in that: described health food is processed granule or other oral solid formulation.
3. the preparation method who improves the health food of memory function as claimed in claim 2 is characterized in that: with the genseng crushed after being dried, cross the 80-200 mesh sieve, and subsequent use; Gynostemma pentaphylla, pseudo-ginseng, barrenwort, fructus alpiniae oxyphyllae; Mulberry fruit was soaked 1～3 hour, reflux 2～4 times, each 1～4 hour; Filter, filtrating merges, and is concentrated into density and is 1.2～1.3 medicinal extract, with genseng fine powder mixing; With press formulation method and add right amount of auxiliary materials, process corresponding oral solid formulation, packing promptly gets.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103461804A (en) * | 2013-08-15 | 2013-12-25 | 当涂县瑞龙果树种植专业合作社 | Bone reinforcing glutinous rice flour containing bone meal, and production method thereof |
| CN104012981A (en) * | 2014-06-19 | 2014-09-03 | 史克勇 | Healthcare food with function of assisting to improve memory |
| CN104055852B (en) * | 2014-06-30 | 2016-04-13 | 广西中医药大学 | Chinese medicine composition for the treatment of senile dementia and preparation method thereof |
| CN105996031A (en) * | 2016-05-15 | 2016-10-12 | 张雅萍 | Japanese ginseng, ginseng and Fructus alpiniae oxyphyllae medicinal and edible composition and preparation method and application thereof |
| CN106039172B (en) * | 2016-07-06 | 2019-10-01 | 南方医科大学 | There is the Chinese medicine composition for improving memory function and its application containing centella |
| CN107029164B (en) * | 2017-05-05 | 2021-11-16 | 上海市杨浦区中心医院 | Pure traditional Chinese medicine composition for treating cognitive function reduction and pure traditional Chinese medicine preparation prepared from same |
| CN107412651A (en) * | 2017-08-22 | 2017-12-01 | 北京京师脑力科技有限公司 | A kind of pharmaceutical composition and preparation method and purposes for improving human body memory |
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| CN1341432A (en) * | 2001-06-15 | 2002-03-27 | 薛志祥 | Brain-tonifying intelligence-raising granules |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341432A (en) * | 2001-06-15 | 2002-03-27 | 薛志祥 | Brain-tonifying intelligence-raising granules |
Non-Patent Citations (1)
| Title |
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| 崔金涛等."中医药治疗老年痴呆近况".《湖北中医杂志》.2001,第23卷(第9期),第51-52页. |
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Address after: Nanning road 530001 the Guangxi Zhuang Autonomous Region City Mingxiu XiXiangTang District No. 179 Patentee after: Guangxi University of Chinese Medicine Address before: Nanning road 530001 the Guangxi Zhuang Autonomous Region City Mingxiu XiXiangTang District No. 179 Patentee before: Guangxi University Of Chinese Medicine |
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Effective date of registration: 20161214 Address after: 535000 Qinzhou Real Estate Industrial Park, the Guangxi Zhuang Autonomous Region Patentee after: Guangxi Taihe Pharmaceutical Co. Ltd. Address before: Nanning road 530001 the Guangxi Zhuang Autonomous Region City Mingxiu XiXiangTang District No. 179 Patentee before: Guangxi University of Chinese Medicine |