CN101496604A - Nutrient foodstuffs with function for reducing blood fat and preparation method thereof - Google Patents
Nutrient foodstuffs with function for reducing blood fat and preparation method thereof Download PDFInfo
- Publication number
- CN101496604A CN101496604A CNA2009100799687A CN200910079968A CN101496604A CN 101496604 A CN101496604 A CN 101496604A CN A2009100799687 A CNA2009100799687 A CN A2009100799687A CN 200910079968 A CN200910079968 A CN 200910079968A CN 101496604 A CN101496604 A CN 101496604A
- Authority
- CN
- China
- Prior art keywords
- portions
- food
- extract
- raw materials
- nutraceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a nutritional food with function of reducing blood fat and a method for preparing the same, which belong to the field of functional foods. The nutritional food with the function of reducing blood fat is mainly prepared from the following medical-edible raw materials in portion by weight: 3 to 10 portions of sessileflower acanthopanax bark tea, 1 to 6 portions of medlar, 1 to 5 portions of fragrant solomonseal rhizome, 1 to 5 portions of sicklesenna seed, 1 to 3 portions of mulberry leaf, 1 to 3 portions of tuckahoe, 2 to 10 portions of hawkthorn, 3 to 8 portions of yam, 3 to 10 portions of sea tangle, 0.2 to 3 portions of evening primrose oil, and 0.2 to 3 portions of safflower oil. Animal and human body experiments prove that the nutritional food has better function of reducing the blood fat, and the used medical-edible raw materials accord with medical-edible homological concept, thus the nutritional food is a veritable green health food and is suitable for both males and females to eat but not suitable for children.
Description
Technical field
The present invention relates to a kind of nutraceutical and preparation method thereof, belong to field of functional food with hypolipemic function.
Background technology
The illness of hyperlipidemia and atherosclerotic, cardiovascular system is one group of disease of harm humans health.General mortality rate in China's cardiovascular and cerebrovascular diseases is only second to malignant tumour, occupies second.
(atherosc1erosis is common a kind of cardiovascular and cerebrovascular diseases AS) to atherosclerotic, also is the common disease of harm humans health.Its basic lesion is the lipidosis of endarterium, inner membrance kitchen range shape fibrillatable, and the formation of atheromatous plaque to tube wall hardening, luminal stenosis, and causes a series of secondary focus.Particularly occur in the heart, the brain organ causes the ischemic pathology.The generation of AS has become developed country and has occupied main causes of death.This disease also has tangible ascendant trend in China in recent years.Be more common in the elderly, but with fastest developing speed with 40～49 years old crowd.According to postmortem report, the incidence of disease of coronary artery and atherosclerosis of aorta is 58.31% in 40～49 years old crowd of China, and the trend that increases with the age is still arranged.Though the definite cause of disease of AS is still unclear, hyperlipidemia is regarded as causing the main hazard factor of AS.Therefore research reduces blood fat crucial economy and social value.
It is what to pay close attention to treatment high fat of blood state that a lot of products has been arranged at present, and for hyperlipidemia, the curative effect of Western medicine is more remarkable, and particularly statins has demonstrated increasing market potential.The reducing blood lipid Western medicine mainly contains four classes:
1. fibrate, this type of medicine has fenofibrate, Gemfibrozil, Bezafibrate etc., and their effect for reducing blood fat are strong, and are rapid-action, and the effect of triglyceride lowering is stronger than norcholesterol;
2. trihydroxy methyl glutaryl-coenzyme inhibitor has Lovastatin, Simvastatin, Pravastatin etc., and they are based on norcholesterol, and effect for reducing blood fat is strong, and is rapid-action;
3. nicotinic acid class, wherein Acipimox is more commonly used, and the effect of falling the serum triacylglycerol is stronger than norcholesterol;
4. pantethine is the derivative of coacetylase, and the effect of serum cholesterol-lowering, triacylglycerol and increasing high density lipoprotein-cholesterol is arranged; Also have cholic acid chelating boron lipid, clofibrate, linoleic acid etc. in addition.
Above-mentioned these medicines can cause that blood sugar raises, feels sick, bad reactions such as abdominal distension, diarrhoea and hepatic disorder in reducing blood lipid.
In view of Western medicine can cause the situation of bigger side effect in reducing blood lipid, seeking new effective reducing blood lipid Chinese medicine becomes when previous important problem.Therefore, before the Chinese medicine that does not find special efficacy, people exist a large amount of demands to nutraceutical better effects if, that have no side effect and that make with medicine and food raw materials, have hypolipemic function.
Summary of the invention
The present invention is directed to the defective in the above-mentioned field, a kind of more efficiently, nutraceutical with hypolipemic function is provided, it forms the theory standard that meets integration of drinking and medicinal herbs fully, is a kind of green nourishing food.
Another object of the present invention has provided a kind of preparation method with nutraceutical of hypolipemic function.A kind of nutraceutical with hypolipemic function, its active component is mainly made by following medicine and food raw materials in portion by weight: Sessileflower Acanthopanax Bark tea 3-10 part, fruit of Chinese wolfberry 1-6 part, radix polygonati officinalis 1-5 part, cassia seed 1-5 part, mulberry leaf 1-3 part, Poria cocos 1-3 part, hawthorn 2-10 part, Chinese yam 3-8 part, sea-tangle 3-10 part, evening primrose oil 0.2-3 part, safflower seed oil 0.2-3 part.
Described nutraceutical, the weight portion of its preferred medicine and food raw materials is: 5 parts of Sessileflower Acanthopanax Bark tea, 2 parts of the fruits of Chinese wolfberry, 2 parts of radix polygonati officinalis, 1 part of cassia seed, 3 parts on mulberry leaf, 1 part in Poria cocos, 8 parts of hawthorn, 5 parts of Chinese yams, 5 parts in sea-tangle, 0.5 part of evening primrose oil, 0.5 part of safflower seed oil.
The formulation of described food and medicament dual-purpose nutraceutical is a soft capsule.
The preparation method of described nutraceutical comprises the steps:
(1) take by weighing radix polygonati officinalis, cassia seed, Poria cocos 3 flavor food and medicament dual-purpose raw materials in proportion, with 70% alcohol extract twice, merge the extract vacuum concentrated dry extract 1;
(2) take by weighing Sessileflower Acanthopanax Bark tea, the fruit of Chinese wolfberry, mulberry leaf 3 flavor food and medicament dual-purpose raw materials in proportion, extract 1 time with aquae destillata, with the extract vacuum concentrate dry extract 2;
(3) take by weighing hawthorn, Chinese yam, sea-tangle 3 flavor food and medicament dual-purpose raw materials in proportion, extract 1 time with aquae destillata, with the extract vacuum concentrate dry extract 3;
Merge dry extract 1,2,3, it be ground into 200 order powder, take by weighing the blending of evening primrose seed oil and safflower seed oil more in proportion after, make soft capsule according to a conventional method.
Also need before the dry extract that obtains after described concentrate is pulverized 50-60 ℃ dry 3 hours down.
Used Sessileflower Acanthopanax Bark tea medicine and food raw materials in this prescription is to cultivate with the patented technology that we have declared, and the stamen leaf of Sessileflower Acanthopanax Bark tea tree is special.
The prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, various capsule, oral liquid, beverage etc.
The present invention adopts soft capsule dosage form, and 1:1.2 mixes with dry extract and edible safflower seed oil, and adds 2% beeswax of extract powder weight, incapsulates.Be because the rhythm of life of considering the modern than very fast, adopts the advantage of soft capsule preparation to be exactly: easy to carry, absorb rapidly, this is a kind of more modern modern preparation type that certain technology content is arranged.
The inventor in long term studies exploitation, by the checking repeatedly of animal and human's body experiment, found above-mentioned better effects arranged have nutraceutical of hypolipemic function and preparation method thereof.
Nutraceutical with hypolipemic function disclosed by the invention, it mainly is to be prepared from according to a certain weight ratio by food and medicament dual-purpose plant Sessileflower Acanthopanax Bark tea, the fruit of Chinese wolfberry, radix polygonati officinalis, cassia seed, mulberry leaf, hawthorn, Chinese yam, sea-tangle, Poria cocos, evening primrose seed oil, kardiseed wet goods.
Sessileflower Acanthopanax Bark tea is the tea that Araliaceae machaka Sessileflower Acanthopanax Bark leaf is made, and Sessileflower Acanthopanax Bark and wilsonii are equal to be belonged to together.Thorn seldom is bordering on stinglessly on Sessileflower Acanthopanax Bark stem, the branch, is distributed in each mountain area on the south the Xiaoxinanlin Mountains, Heilongjiang Province.The Sessileflower Acanthopanax Bark branches and leaves are luxuriant, and flowers and fruits are unusual, are a kind of wild vegetable and important medicinal plants of keeping healthy.The tea that the Sessileflower Acanthopanax Bark leaf is made contains micro-biological alkali and 0.2% volatile oil and nicotinic acid, contains 0.23% cardiac glycoside and the pharmacological action of a small amount of saponin Sessileflower Acanthopanax Bark tea is multifarious, has strengthening by means of tonics, adjusts effects such as blood pressure, nerve, blood sugar and cholesterol.
The fruit of Chinese wolfberry is the fruit of plant of Solanaceae lycium barbarum Lycium barbarum L.Have nourishing liver and kidney, the effect of benefiting shrewd head.It is thanks to smart to be used for consumptive disease, soreness of waist and knee joint, and dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear.Tao Hongjing: " nourishing the essence and strengthening QI, prosperous and powerful vagina." " property of medicine opinion ": " the smart various symptims and signs of deficiency of energy help, easily color bleaches, and makes eye bright, and calms the nerves." " dietetic materia medica ": " hard muscle is anti-old, removes wind, and help muscles and bones can benefit be gone into, and removes consumptive disease." Wang Haogu: " main worry choke is done, and is pained, draws drink yearningly, during ephrosis disappears." " detailed outline ": " nourshing kidney, moistening lung make eye bright." " book on Chinese herbal medicine is stated ": " treat the liver wind deficiency of blood, the swelling ophthalmalgia confused screen of itching." it is dizzy to control apoplexy, and consumptive disease is allly seen blood trouble, cough blood, impotence, faint, contraction, the miasma that disappears is hindered dryly, passes out semen reddish and whitish turbid urine, beriberi, the arthroncus of knee.”
Radix polygonati officinalis this product is at the dry rhizome that closes section plant radix polygonati officinalis.Main product Hunan, Henan, Jiangsu, Zhejiang; Cultivation is arranged.Have another name called luxuriant, luxuriant, Wei ginseng." main apoplexy sudden-heat can not shake, and falls muscle knot meat, various symptims and signs of deficiency in the Shennong's Herbal record." " book on Chinese herbal medicine justice " record " radix polygonati officinalis, the sweet greasiness of distinguishing the flavor of, soft and moist product.It is scorching that the lung stomach is controlled in modern thought, and body fluid dries up, and thirsty choke is done and waited disease, and exuberance of stomach fire, the dry paddy that disappears yearningly, the polyorexia person has especially very and imitates." gas is little, it is sweet to distinguish the flavor of, and that chews must stick.Flavor efficacy: it is sweet to distinguish the flavor of, and property is flat.Attach to the lung and stomach meridians.Nourishing Yin and moistening lung, nourishing the stomach to improve the production of body fluid.Chemical composition: rhizome contains convallamarin, convallarin and Kaempferia galanga, d-quercitol glycosides and vitamin A, still starch-containing and lymphatic temperament.Also contain 4 kinds of radix polygonati officinalis levulan.Pharmacological action: this product can strengthen immunity, hemangiectasis, anti-acute myocardial ischemia, step-down, anti-ageing, antibiotic, reducing blood lipid, anti arteriosclerosis, antitumor, defaecation, hypoglycemic etc.
Mulberry leaf this product is the dried leaves of moraceae plants mulberry.Gas is little, lightly seasoned, little bitterness.Flavor efficacy: sweet, bitter, cold.Return lung, Liver Channel.Dispelling wind and heat from the body, clearing away the lungheat and moisturizing is clear liver and improved vision.Chemical composition: leaf contains rutin sophorin, Quercetin, isoquercitrin, volatile oil, fumaric acid, tartaric acid, citric acid, vitamin C, glutathione, folic acid, vitamin B1, vitamin B2, adenine, choline, trigonelline etc.Pharmacological action: have spasmolysis, resisting pathogenic microbes, anti-inflammatory, hypoglycemic, bring high blood pressure down, reducing blood lipid, diuresis.
Ligusticum wallichii this product is the rhizome of samphire Ligusticum wallichii Ligusticum wallichii France..Contain alkaloid, as ligustrazine (Tetramethylpyrazine, tetamethyl-pyrazine), perlolyrine (perlolyrine) leucyl benzenpropanoic acid lactams (leucylphenylalanine anhydride), gland pyrimidine (adenine), L-valyl-L-valine acid anhydride (L-valine-L-valine anhydride), trimethylamine (trimethy-lamine), choline (choline) Pei Luoliling (perlolyrine).Intervene atherosclerotic moulding rabbit with ligustrazine, comparative study atherosclerosis of aorta extent of disease, and observe the variation of serum cholesterol (TC), triglycerides (TG) and endothelin level-1 (ET-1).The result shows, serum TC and TG, and there was no significant difference before and after the normal diet group experiment (P〉0.05), high lipid food group (P＜0.05), TG difference be (P〉0.05) not significantly.
Chinese yam is a Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb. stem tuber.Also name is affixed one's name to pre-(the Classic of Mountains and Rivers), Chinese yam, sweet potato (" herbal classic "), Chinese yam rhizome (" medicine materical crude slice is newly joined ") etc.It is sweet to distinguish the flavor of, and property is flat.Return lung, spleen, kidney channel.Function: invigorating the spleen, tonifying lung, reinforce the kidney, benefit is smart.Main component: stem tuber contains Dioscin (dioscin), and its sapogenin is diosgenin (diosgenin).Also contain lymphatic temperament, choline (choline), starch, glycoprotein, end power plain (D-abscisin II), polyphenol oxidase, vitamin C, 3,4-dihydroxy benzenes ethamine (3,4-dihydroxypheny-lethylamine).Contain mannosan (mannan) and phytic acid (phyticacid) in the mucus.Pharmacological experiment study shows that Dioscin has effects such as treatment angina pectoris, reducing blood lipid.
Cassia seed is the mature seed of legume Cassia tora Cassia obtusifolia L. or little Cassia tora Cassia toral..Fresh seeds contains yellow phenol, archen, aloe-emodin, Rhein, emodin monoglucoside, emodin anthrone, Physcion, obtusin (1,6,7-trimethoxy-2,8-dihydroxy-3-tectoquinone), aurantio-obtusin (1,7-dimethoxy-2,6,8-three hydroxyls-3-3 tectoquinone), protein and anthraquinone glycoside and rubrofusarin, Cassia tora pine, toralactone, chrysophanic acid-9-anthrone.Also contain vitamin A.Experiment shows that cassia seed protein, anthraquinone glycoside all can reduce T-CHOL, triglycerides and the LDL-C of hyperlipidemia rats.
Hawthorn is the fruit of rosaceous plant hawthorn Crataegus pinnatifida Bge. or fructus crataegi cuneatae.Also haw in the famous mountain.Main component is organic acid and flavone compound.Select for use the Wistar male rat as research object, when using high lipid food to feed, irritate stomach, measure superoxide dismutase (SOD) and MDA (MDA) in the liver tissues of rats after 5 weeks with the hawthorn and the hawthorne leaf P.E of 3 kinds of various dose.Find that hawthorn and leaves of Hawthorn can improve SOD activities of liver, and partly reduce MDA content in the hepatic tissue (P＜0.05), wherein MDA content is higher than high fat control group (P＜0.05) in the high dose leaves of Hawthorn intervention group liver tissues of rats; Hawthorn is better than leaves of Hawthorn in effect aspect the increase SOD vigor.The result shows that hawthorn and leaves of Hawthorn have effect for reducing blood fat.
Poria cocos has another name called Yun Ling, Song Ling, Fu spirit, is the dry sclerotia of Polyporaceae fungi Fu Poriacocos (Schw.) Wolf, and multiparasitization is in the root of masson pine or Japanese red pine.Mainly contain B-pachyman, pachymic acid, lecithin and sterol etc.Pharmacology 1: diuresis.2: sedation, the Poria cocos decoction is used lumbar injection to mouse, can suppress spontaneous activity, and can resist caffeine induced mice surexcitation, and the anesthesia of barbital is had synergy.3: the cardiovascular system ethanol extract is strengthened myocardial contractive power, and heart rate increases.4: the digestive system Poria cocos has significant protective effect for the caused mouse liver injury of carbon tetrachloride.5: the antitumor action pachymaran has inhibitory action to murine sarcoma, and its effect is relevant with thymus gland, can activate local complement.
Sea-tangle has another name called kelp, sea grass, belongs to perennial heavy this plant of pasture and water of Da Ye marine alga section, and simple structure is thallus, does not have the difference of root, stem, leaf, but the chlorophyll of cell can carry out photosynthesis.The traditional Chinese medical science thinks that sea-tangle is cold in nature, flavor is salty, function softening and resolving hard mass, clearing away heat and promoting diuresis, fat removing and decompression.Sea-tangle also contains special dietary compositions such as the acid of algae glue, laminaran, sweet mellow wine, galactan, sea-tangle glycan, laminine, glutamic acid, carrotene, starch and iodine except that containing general nutritional labeling such as large quantity of moisture, protein, crude fibre, fat, carbohydrate, calcium, phosphorus, iron, vitamin B1, vitamin B2, vitamin C.It is abundant that sea-tangle contains iodine, can prevent and treat hypertension and artery sclerosis.The human body iodine deficiency, the thyroid gland secretion weakens will make the carbohydrate fat oxidation insufficient, forms cholesterol and fat in vivo, causes human body to be got fat or artery sclerosis.Sea-tangle can hinder the absorption of human body to cholesterol, plays the effect that reduces cholesterol.
Evening primrose seed oil this product is the oil of the plant evening primrose Oenothera biennisL. of willow leaf section seed.The evening primrose seed oil is rich in linoleic acid, and the effect of regulating blood fat is arranged.Evening primrose oil and evening primrose oil sodium salt (3 times/day, irritate stomach, 25 days) make the TG level of rat all significantly be lower than control group (P＜0.01), and the latter is more remarkable, and the Serum HDL-C level then is significantly higher than control group, and the effect of sodium salt is more obvious.The evening primrose seed oil also can reduce TC level in the blood, reduces the content of TC in the experimental rat fatty liver, suppresses the generation of fatty liver.Evening primrose oil is ingested and growth has no adverse effects to rat under 6% absorption level, and the disorders of lipid metabolism state is got necessarily improve, and prompting may be of value to atherosclerotic control to a certain extent by regulating blood fat.
The safflower seed oil Compendium of Material Medica: safflower is published the west city, and it is sweet nontoxic to distinguish the flavor of, its seed function with spend identically, can manage it man's blood vessels, lead to the woman through water, promoting circulation of blood is at most nourished blood at least." Bencao Jingshu ": safflower be promoting circulation of blood medicine also." book on Chinese herbal medicine converges and says ": safflower, break and bleed, nourish blood ..." medicine soup justice ": safflower is apt to the tonneau passages through which vital energy circulates, is gas medicine in the blood, can let out and can mend, and wonderful justice is respectively arranged.Safflower belongs to composite family, is a kind of traditional medicinal plant of preciousness, originates between the Altai in Xinjiang Province and the Mountain Ranges of Tian Shan Mountains, and output accounts for more than 80% of the whole nation.Unique geographical environment is given here annual sunshine and the Chinese unique Atlantic Ocean monsoon climate that surpasses 3000 hours, she is pregnant with show unique characteristics, colory safflower seed oil raw material.As good oil crops, its linoleic acid content is the highest in all known plants.Need not fertilizer and pesticide in the safflower growth course, and cold-resistant, barren-resistant, be real natural green food raw material.The ecosystem high-quality safflower seed oil that safflower seed oil selects for use Chinese thornless safflower native place-Tacheng people to abound with is a raw material.Utilize advanced technology and equipment, form through the science processing and refining.Color and luster is limpid orange, edible good to eat, be rich in unrighted acid and multiple nutrients compositions such as linoleic acid, vitamin, wherein linoleic acid content up to 83%, content of vitamin E is up to 1600 milliequivalent/kilograms, is described as " linoleic acid five ", " hat of vitamin E ".This product does not contain chemicals, is excellent pollution-free food.Dailyly fry, fry in shallow oil, explode, mix, directly oral result is better.Unrighted acid is a kind of essential aliphatic acid that constitutes body fat, can be divided into two kinds of monounsaturated fatty acids and polyunsaturated fatty acids.In the food fat, monounsaturated fatty acids has oleic acid, and polyunsaturated fatty acid has linoleic acid, leukotrienes, arachidonic acid etc.Human body can not synthesize linoleic acid plus linolenic acid, must replenish from meals.Linoleic acid be needed by human but can not be in vivo synthetic voluntarily unrighted acid, must from meals, absorb, can cause the liver metabolism disorder if human body has lacked unrighted acid, haemoconcentration thickens the soup, accumulation of cholesterol makes vascular wall follow the string gradually, until sclerosis.Cause a series of cardiovascular and cerebrovascular diseases thus, as hypertension, brain overflow, heart disease, heart and brain blood are thick, hemiplegia, apoplexy etc.Linoleic acid mainly shows the effect of human body: soften cardiovascular and cerebrovascular, blood circulation, blood fat-reducing blood pressure-decreasing, enhance metabolism, regulate endocrine and delaying senility etc.Therefore, linoleic acid have the good reputation of " blood vessel street cleaner ".The medical research of state such as India and Japan experiment institute shows numerous atherosis patients' experiment: edible pure three week of safflower seed oil the back cholesterol attempt descending 10%, eat for a long time, blood fat, blood pressure all can return to normal level.The linoleic acid content of 100% pure safflower seed oil is the highest in the known plants oil, up to about 80%.Its bioactive ingredients can lipopenicillinase, invigorate blood circulation, step-down, softening blood vessel, resistance thrombus, improve the heart blood circulation, regulate internal system, recover nervous function indirectly.Long-term eating can demonstrate huge effect.Safflower seed oil residence medicine is in food, and residence is mended in food, and headachy persistent ailment hidden danger is eliminated on dining table, real wisdom chapter for dietary therapy of Chinese medicine health care.After directly taking safflower seed oil, linoleic acid and cholesterol synthetic fat, and then impel it to be degraded to cholic acid to excrete with urine, sweat.Safflower seed oil can effectively be regulated blood fat, and prophylactic generation is a mode that effective Practical science is easy.
The traditional Chinese medicine and pharmacy of hyperlipidemia understanding and therapy are thought: the name of disease of traditional Chinese medical science ahyperlipoidemia, and according to reason, pathogenic characteristic and the associated diseases that hyperlipidemia produces, it can be concluded that phlegm in motherland's medical science is turbid, in the blood stasis, carry out dialectical executing and control.Clinical and experimental study has also confirmed hyperlipidemia and phlegm is turbid, blood stasis has quite similar place.
The traditional Chinese medical science thinks that the spleen is the source of growth and development, and The spleen has the function to transport and transform nutrients, and the both angry blood of precise and tinyization of transporting and transforming nutrients from foodstuff, but transmitting and distributing the fluids are again regulated the body fluid metabolism of human body; The traditional Chinese medical science thinks how hyperlipidemia patient sees that with liver-kidney Yin deficiency the deficiency of Yin is liver heat then more, easily causes stagnation of the circulation of vital energy phlegm and coagulates, and this also is the factor that hyperlipidemia forms.
In sum, the inventor thinks that the use herbal cuisine is summarized as follows with the therapy of derived food to hyperlipidemia:
1. tonify the liver and kidney, in the reducing blood lipid liver and gall of radically reforming are shown each other, liver controlling conveyance and dispersion, the secretion of decision bile, bile directly helps the digestion of food, influences the fortune function of taste.Liver dysfunction, the qi and blood heap soil or fertilizer over and around the roots is held back, and become estranged in the network road, and sering is unfavorable, and then blood fat raises.So the food and medicament dual-purpose plant material that employing is tonified the liver and kidney such as the fruit of Chinese wolfberry, Chinese yam, hawthorn etc.
2. the invigorating the spleen spleen insufficiency of regulating the flow of vital energy is pure and impure, stops body fluid and phlegm is given birth to, and blood is turbid.The gas heap soil or fertilizer over and around the roots is held back and the blood fat liter.Adoptable food and medicament dual-purpose plant material has Sessileflower Acanthopanax Bark tea, hawthorn etc.
3. promoting blood flow and remove blood stasis, the adoptable food and medicament dual-purpose plant material of nourishing the blood and yin kardiseed wet goods.Studies show that the promoting blood flow and remove blood stasis medicine can suppress platelet agglutination, alleviate the artery inner lipid and soak into, prevent that patch from forming and promotion is disappeared.
4. clearing heat and detoxicating adoptable food and medicament dual-purpose plant material has mulberry leaf, radix polygonati officinalis etc.
5. the clearing damp adoptable food and medicament dual-purpose plant material that reduces phlegm has sea-tangle, seed of Radix Oenotherae erythrosepalae wet goods.
6. the adoptable food and medicament dual-purpose plant material of defaecation has cassia seed, Poria cocos etc.
The used medicine of the present invention adopts methods such as the alcohol extract, aqueous solution soaking extraction, distilled water extraction of different purity respectively, the temperature that refluxes all is lower than 100 ℃, make active ingredient in the medicine be difficult for Yin Gaowen and change, when concentrated, adopt vacuum to concentrate simultaneously, make the active ingredient in the extract not be subjected to temperatures involved, avoided some destruction and loss, preserved the nutritional labeling and the fragrance of raw material better heat-labile active ingredient.The dry extract that obtains after concentrating need 50-60 ℃ dry 3 hours down, could finish-drying.
The nutritional food formula of this auxiliary lipid-lowering function and products thereof production technology shows nutraceutical effect of the present invention by testing example, and test comprises function assessment test and security toxicology test.Specifically see the following examples and experimental example for details.
The specific embodiment
Further set forth preparation method and effective effect of functional nutrient food of the present invention by the following examples with the test example.
Embodiment 1.
Feed proportioning:
Sessileflower Acanthopanax Bark tea 5000g, fruit of Chinese wolfberry 2000g, radix polygonati officinalis 2000g, cassia seed 1000g, mulberry leaf 3000g, hawthorn 8000g, Chinese yam 5000g, sea-tangle 5000g, Poria cocos 1000g, evening primrose oil 500g, safflower seed oil 500g.
Its preparation method:, be prepared according to claims and described nutrient food preparation of this specification.
Embodiment 2
Feed proportioning:
Sessileflower Acanthopanax Bark tea 10000g, fruit of Chinese wolfberry 4000g, radix polygonati officinalis 4000g, cassia seed 2000g, mulberry leaf 6000g, hawthorn 16000g, Chinese yam 10000g, sea-tangle 10000g, Poria cocos 2000g, evening primrose oil 1000g, safflower seed oil 1000g.
Its preparation method:, be prepared according to claims and described nutrient food preparation of this specification.
Embodiment 3
Feed proportioning:
Sessileflower Acanthopanax Bark tea 15000g, fruit of Chinese wolfberry 6000g, radix polygonati officinalis 6000g, cassia seed 2000g, mulberry leaf 9000g, hawthorn 24000g, Chinese yam 15000g, sea-tangle 15000g, Poria cocos 3000g, evening primrose oil 1500g, safflower seed oil 1500g.
Its preparation method:, be prepared according to claims and described nutrient food preparation of this specification.
This nutraceutical is raw materials used to be: the allowance of the Ministry of Public Health, national Bureau of Drugs Supervision files specify is used for the raw material of the medicine-food two-purpose of nutraceutical.
The hypolipemic function of this nutraceutical can obviously reduce T-CHOL and total content of triglyceride in the serum, increases HDL content, reduces LDL content, improves the activity of LCAT.
Experimental example one:
Consider to influence result's principal element, with the comparativity between the assurance group.Every group of experimenter's 10 examples.The test-meal group is oral 700mg/d every day by trying thing (embodiment 5 preparation nutraceutical) adult recommended amounts, by adult 60kg batheroom scale, i.e. and 12mg/ (kg body weight), control group is taken fenofibrate, consumption (300mg/d).Tried thing and given time 30d.
The zoopery situation is as follows
(1) principle forms experimental hyperlipidemia with high cholesterol and lipid forage feed animal, giving animal again, to be tried thing (be the nutraceutical of embodiment 1 preparation, down together), can detect and be tried the influence of thing to hyperlipidemia, decidable is tried thing to the absorption of lipid, the formation of lipoprotein, the degraded of lipid or the influence that drainage produces.
(2) instrument and reagent
Disscting instrument, 721 spectrophotometers, automatic biochemistry analyzer, cholesterol, cholate, serum total cholesterol (TC), triglycerides (TG), HDL HDL-C measure kit.
(3) animal is selected and feed
Animal used as test is selected: cleaning level, SD kind healthy adult male rat 160～180g, 100.Available from medical animal experiment center, Wuhan City, the animal quality certification number: Hubei Province doctor's examination 0708. occupancy permit number: EYS0805.High lipid food prescription: 79% basal feed, 1% cholesterol, 10% yolk powder and 10% lard.
(4) tried thing and dosage grouping experiment and established three groups, a normal forage feed group, one is high lipid food nursing group, other is tried the thing group.Survey and tried thing and irritate stomach according to the physicochemical property suspension to animal, every day 1 time.Test procedure
1. the rat feeding basal feed is observed 5～10d to rat disorders of lipid metabolism model (preventative giving tried thing) under experimental situation, get tail blood then, measure serum total cholesterol (TC), triglycerides (TG), whether HDL-C (observe normal by the level of HDL-C).According to serum total cholesterol (TC) level, carry out random packet, when giving high lipid food, give the thing that tried of various dose, regularly weigh in, in off-test fasting 16h, measure serum TC, TG, HDL-C level.
2. the rat feeding basal feed is observed 5～10d to rat disorders of lipid metabolism model (therapeutic is given and tried thing) under experimental situation, get tail blood then, measure serum total cholesterol (TC), triglycerides (TG), whether HDL-C (observe normal by the level of HDL-C).
When formal test began, each treated animal was all used high lipid food instead and is fed and raise 7～10d, and tail vein blood is measured serum TC, TG, and HDL-C level is to determine whether to form hyperlipemia model.According to the TC level, carry out random packet again, tried the thing per os and irritate stomach, high fat control group gives the solvent with volume, continues to give high lipid food, and regularly weighs in, and when off-test, tail vein blood is measured serum TC, TG, HDL-C level.The hypolipemic function zoopery of this nutraceutical the results are shown in Table 1,2:
This nutraceutical of table 1 is to the reducing blood lipid effect (cholesterol) of rat experiment high fat of blood (unit: the mmol/L of X ± SD)
* P＜0.01 compares with the high fat of blood group that there were significant differences.
This nutraceutical of table 2 is to mouse experiment high fat of blood prophylactic effect (X ± SD)
* there were significant differences (P＜0.01) with the high fat of blood group.
There were significant differences for Δ Δ and normal group (P＜0.01).
+ with self was with reference to there were significant differences (P＜0.05) in the 0th day.
According to " health food check and assessment technique standard " (2003 editions) criterion, show that through zoopery nutraceutical of the present invention has tangible hypolipemic function to the hypolipemic function nutraceutical.
Experimental example 2 human feeding trials
2.1 experimenter's selection
The experimenter is non-hyperlipidemia patient of being in hospital, and belongs to the crowd of simple dyslipidemia, the voluntary participation test.Keep on ordinary days life and eating habit during being tried, get the every index of hematometry on an empty stomach, blood sampling is 2 times in half a year, be 〉=5.2mmol/L or serum TG 〉=1.65mmol/L with twice serum TC, as selecting data, on the basis of reference animal test results, selecting the unusual person of These parameters is study subject.
2.2 there is the following situation person should not be as the experimenter: merge have the inclination, serious diseases such as liver, kidney and hemopoietic system, the mental patient; Take the article relevant in a short time, have influence on judgement person the result with being tried function.
2.3 the experiment grouping is divided into the test-meal group at random and takes the fenofibrate control group by experimenter's blood lipid level
2.4 this nutraceutical sees Table 3 to the lipid-lowering effect of people with hyperlipidemia:
Table 3 is taken nutraceutical front and back lipid lowerers consumption of the present invention and the average change in concentration of blood fat
Table 3 data show that serum cholesterol and triglycerides mean concentration all do not have significant difference before two groups of tests, but test
After group is taken nutraceutical of the present invention, do not use any other lipid lowerers, can reach the lipopenicillinase purpose.According to " health food check and assessment technique standard " (2003 editions) criterion, show that through zoopery and human experimentation nutraceutical of the present invention has tangible hypolipemic function to the hypolipemic function nutraceutical.
Claims (7)
1, a kind of nutraceutical with hypolipemic function, it is mainly made by following medicine and food raw materials in portion by weight: Sessileflower Acanthopanax Bark tea 3-10 part, fruit of Chinese wolfberry 1-6 part, radix polygonati officinalis 1-5 part, cassia seed 1-5 part, mulberry leaf 1-3 part, Poria cocos 1-3 part, hawthorn 2-10 part, Chinese yam 3-8 part, sea-tangle 3-10 part, evening primrose oil 0.2-3 part, safflower seed oil 0.2-3 part.
2, nutraceutical according to claim 1, the weight portion of its preferred medicine and food raw materials is: 5 parts of Sessileflower Acanthopanax Bark tea, 2 parts of the fruits of Chinese wolfberry, 2 parts of radix polygonati officinalis, 1 part of cassia seed, 3 parts on mulberry leaf, 1 part in Poria cocos, 8 parts of hawthorn, 5 parts of Chinese yams, 5 parts in sea-tangle, 0.5 part of evening primrose oil, 0.5 part of safflower seed oil.
3, the formulation according to the described food and medicament dual-purpose nutraceutical of claim 1 is a soft capsule.
4, the preparation method of nutraceutical according to claim 1 comprises the steps:
(1) take by weighing radix polygonati officinalis, cassia seed, Poria cocos 3 flavor food and medicament dual-purpose raw materials in proportion, with 70% alcohol extract twice, merge the extract vacuum concentrated dry extract 1;
(2) take by weighing Sessileflower Acanthopanax Bark tea, the fruit of Chinese wolfberry, mulberry leaf 3 flavor food and medicament dual-purpose raw materials in proportion, extract 1 time with aquae destillata, with the extract vacuum concentrate dry extract 2;
(3) take by weighing hawthorn, Chinese yam, sea-tangle 3 flavor food and medicament dual-purpose raw materials in proportion, extract 1 time with aquae destillata, with the extract vacuum concentrate dry extract 3;
Merge dry extract 1,2,3, it be ground into 200 order powder, take by weighing the blending of evening primrose seed oil and safflower seed oil more in proportion after, make soft capsule according to a conventional method.
5, also need before the dry extract that obtains after described concentrate is pulverized 50-60 ℃ dry 3 hours down.
6, used Sessileflower Acanthopanax Bark tea medicine and food raw materials in this prescription is to cultivate with the patented technology that we have declared, and the stamen leaf of Sessileflower Acanthopanax Bark tea tree is special.
7, the prepared dry extract active component of the present invention can add various conventional auxiliary material required when preparing different dosage form, as disintegrant, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as pill, electuary, tablet, various capsule, oral liquid, beverage etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100799687A CN101496604A (en) | 2009-03-16 | 2009-03-16 | Nutrient foodstuffs with function for reducing blood fat and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100799687A CN101496604A (en) | 2009-03-16 | 2009-03-16 | Nutrient foodstuffs with function for reducing blood fat and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101496604A true CN101496604A (en) | 2009-08-05 |
Family
ID=40944040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009100799687A Pending CN101496604A (en) | 2009-03-16 | 2009-03-16 | Nutrient foodstuffs with function for reducing blood fat and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101496604A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652552A (en) * | 2013-12-02 | 2014-03-26 | 中国农业大学 | Functional food with effects of reducing lipid and preventing fatty liver |
| CN107596119A (en) * | 2017-09-11 | 2018-01-19 | 黑龙江引创基因生物技术有限公司 | A kind of Poria cocos compound surrogated tea and preparation method thereof |
| CN108714172A (en) * | 2018-08-17 | 2018-10-30 | 河南树铭药业有限公司 | A kind of solid beverage of lowering blood-fat and reducing weight and preparation method thereof |
| CN112655826A (en) * | 2020-11-27 | 2021-04-16 | 吉林大学 | Rumen-bypass health-care granules for preventing and treating fatty liver of dairy cow in perinatal period |
-
2009
- 2009-03-16 CN CNA2009100799687A patent/CN101496604A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652552A (en) * | 2013-12-02 | 2014-03-26 | 中国农业大学 | Functional food with effects of reducing lipid and preventing fatty liver |
| CN103652552B (en) * | 2013-12-02 | 2014-12-24 | 中国农业大学 | Functional food with effects of reducing lipid and preventing fatty liver |
| CN107596119A (en) * | 2017-09-11 | 2018-01-19 | 黑龙江引创基因生物技术有限公司 | A kind of Poria cocos compound surrogated tea and preparation method thereof |
| CN108714172A (en) * | 2018-08-17 | 2018-10-30 | 河南树铭药业有限公司 | A kind of solid beverage of lowering blood-fat and reducing weight and preparation method thereof |
| CN108714172B (en) * | 2018-08-17 | 2021-03-23 | 河南树铭药业有限公司 | Solid beverage for reducing fat and losing weight and preparation method thereof |
| CN112655826A (en) * | 2020-11-27 | 2021-04-16 | 吉林大学 | Rumen-bypass health-care granules for preventing and treating fatty liver of dairy cow in perinatal period |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102986887B (en) | Health maintenance flavor milk shake and preparation method thereof | |
| CN102160573B (en) | Milk shake for replacing meal and preparation method thereof | |
| CN101695376B (en) | Health-care food for preventing diabetes | |
| CN104322617B (en) | Biscuit of a kind of auxiliary hyperglycemic and preparation method thereof | |
| CN103099089A (en) | Health-care product for reducing blood sugar and blood pressure, relaxing bowels, losing weight, resisting fatigue and improving sexual function and production technology thereof | |
| CN102178237B (en) | Kushui rose oil soft capsules | |
| CN101229213A (en) | Rhodiola rosea compound healthy product | |
| CN103027155A (en) | Mulberry leaf lipid-reducing pressure-reducing health-care tea and preparation method thereof | |
| CN109329680A (en) | A kind of composition containing ginseng extract and functional beverage as made from it | |
| CN108524814A (en) | A kind of Chinese medicine composition and preparation method thereof for reducing blood glucose | |
| CN102940153A (en) | Poultry feed for improving meat quality and egg quality | |
| CN105454576A (en) | Jasmine-flower-comprising assorted Chinese herbal tea and preparation method thereof | |
| CN103555530A (en) | Lily healthcare medicinal liquor | |
| CN101243882B (en) | Health food with function of reducing blood fat and its preparation | |
| CN106343567A (en) | Noni oral liquid and preparing method thereof | |
| CN103461585B (en) | Qi tonifying and health preserving herbal tea | |
| CN107853517A (en) | A kind of antifatigue Chinese medicinal drink and preparation method thereof of refreshing oneself | |
| CN101496604A (en) | Nutrient foodstuffs with function for reducing blood fat and preparation method thereof | |
| CN105595047A (en) | Feed for meat geese | |
| CN108813501A (en) | With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung | |
| CN105412277A (en) | Traditional Chinese medicinal composition of lipid-lowering tea and application of traditional Chinese medicinal composition | |
| CN102511876B (en) | Hawthorn red jujube thick syrup and production process thereof | |
| CN110638038A (en) | Medical formula nutritional meal replacement powder for controlling hyperglycemia and preparation method thereof | |
| CN110063394A (en) | A kind of preparation method of full-natural nutritive immunizing health solid beverage cordyceps tea | |
| WO2023100764A1 (en) | Composition for preventing, improving or alleviating symptoms relating to qi deficiency and/or blood deficiency |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Beijing Huizhong Mingjie Biological Technology Co., Ltd. Document name: Notification of before Expiration of Request of Examination as to Substance |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20090805 |